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13.1264 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
(10)Tj
6.7246 0 0 5.9768 195.1369 71.2063 Tm
(9)Tj
8.9663 0 0 8.9663 198.5385 67.2378 Tm
[(/L\),)-317.7(no)-321.5(patient)-323.3(had)-323.4(a)-318.1(coagu-)]TJ
-15.2256 -1.1128 TD
[(lopathy)-285.3(or)-286.2(was)-283.7(receiving)-291.7(anticoagulant)-285(therapy)-286.3(before)-285.3(the)-289.5(trauma.)]TJ
27.9978 74.5598 TD
[(Low-dose)-682(antithrombotic)-675.5(therapy)-678.3(with)-679.6(low-molecular)-676.3(weight)]TJ
0 -1.1128 TD
[(heparin)-197.7(\(LMWH;)-192.8(Dalteparin)-197.4(25005000)-185.3(units\))-192.3(was)-195.1(administered)-191.5(to)]TJ
T*
[(16/30)-343(patients)-343(at)-340.6(mean)-341.5(6)-340.9(days)-343.1(\(standard)-339.6(deviation)-341.3([SD])]TJ
/F5 1 Tf
23.1102 0 TD
()Tj
/F4 1 Tf
.5564 0 TD
[(4)-334.6(days\))]TJ
-23.6667 -1.1065 TD
[(post-trauma.)-444(The)-443.4(LMWH)-440.1(was)-441.7(administered)-444.4(after)-441.6(acquisition)-440.4(of)]TJ
0 -1.1128 TD
[(MRI)-291.1(images)-288.9(in)-287.6(all)-287.2(but)-287.1(two)-284.1(patients,)-289(in)-287.6(whom)-289.4(LMWH)-288.3(was)-283.7(admin-)]TJ
T*
[(istered)-285.1(1)-277.7(day)-285.5(before)-279(the)-283.2(MRI.)]TJ
/F9 1 Tf
0 -2.7505 TD
[(Neurointensive)-335.9(care)]TJ
/F4 1 Tf
1.1128 -1.7514 TD
[(All)-205.9(patients)-210.2(in)-205.4(the)-207.3(presented)-213(study)-205.1(were)-211.1(treated)-210.5(at)-207.8(the)-207.3(NIC)-205.2(unit)-208.4(at)]TJ
-1.1128 -1.1065 TD
[(the)-302.2(Uppsala)-307.1(University)-301.2(Hospital.)-302.5(The)-297.9(patients)-305(were)-299.6(ventilated)-303(en-)]TJ
0 -1.1128 TD
[(dotracheally)-378.9(and)-367.7(sedated)-375.8(using)-369.5(a)-368.7(combination)-375.5(of)-368.4(intermittent)-377(in-)]TJ
T*
[(travenous)-330.7(\(IV\))-325.3(morphine)-324.8(analgesia)-330.7(\()-84.3(Morn)-328.2(Meda)-326(13)-162.9(mg,)-327.9(Meda,)]TJ
T*
[(Sollentuna,)-841.8(Sweden\))-834.2(and)-835.6(continuous)-835.1(IV)-833.2(propofol)-833.6(infusion)]TJ
0 -1.1065 TD
[(\(Propofol-Lipuro)-283.5(14)-169.3(mg/kg/h,)-276.6(B.)-285.4(Braun)-279.2(Melsungen)-284.6(AG,)-280.4(Melsun-)]TJ
0 -1.1128 TD
[(gen,)-440.2(Germany\).)-445.9(All)-439.8(patients)-444.1(had)-437.2(ICP)-440.7(monitoring)-437(\(Codman)-446.1(ICP)]TJ
T*
[(express)-474.3(intraparenchymal)-474(monitor)-472.3(in)-470.9(22)-466.9(patients,)-472.3(external)-469.2(ven-)]TJ
0 -1.1065 TD
[(tricular)-188.9(drain)-183.6(in)-180.1(8)-182.9(patients\))-187(for)-187.1(continuous)-183.8(measurements)-184.3(of)-185(ICP)-181.5(and)]TJ
0 -1.1128 TD
[(cerebral)-286.9(perfusion)-280.3(pressure)-286.7(\(CPP\).)]TJ
1.1128 -1.1128 TD
[(Patients)-341.6(with)-331.9(TBI)-340.8(were)-337.6(treated)-336.9(using)-337.9(an)-336.6(ICP-)-335.4(and)-336.1(CPP-guided)]TJ
-1.1128 -1.1128 TD
[(standard)-255.3(protocol)-243.1(including)-250.4(mild)-249.9(hyperventilation)-249.8(initially)-249.8(\(PaCO)]TJ
6.7246 0 0 5.9768 548.844 524.5227 Tm
(2)Tj
8.9663 0 0 8.9663 313.0582 516.0754 Tm
[(3035)-168.3(mm)-309.6(Hg;)-303(4.04.5)-167.8(kPa\),)-308.1(30-degree)-311.6(elevated)-311(head)-306.4(of)-305.1(bed,)-307.4(and)]TJ
T*
[(volume)-272.6(expansion)-271.2(to)-274.9(normovolemia)-269.6(and)-272.8(a)-267.5(central)-273.7(venous)-272.6(pressure)]TJ
T*
[(of)-317.8(05)-162.9(mm)-315.9(Hg.)]TJ
6.7246 0 0 5.9768 368.2771 500.0881 Tm
(19)Tj
8.9663 0 0 8.9663 377.8015 496.1195 Tm
[(To)-315(minimize)-317.2(secondary)-316.5(brain)-310.1(injury,)-314.1(the)-314.8(aim)-312(of)]TJ
-7.2208 -1.1128 TD
[(treatment)-292.9(was)-283.6(to)-287.6(keep)-281.1(ICP)-289(at)]TJ
/F5 1 Tf
12.0199 0 TD
(<)Tj
/F4 1 Tf
.5501 0 TD
[(20)-169.7(mm)-284.3(Hg)-280.5(and)-285.5(CPP)-285(at)]TJ
/F5 1 Tf
9.3136 0 TD
(>)Tj
/F4 1 Tf
.5564 0 TD
[(60)-163.4(mm)-284.3(Hg)]TJ
-22.44 -1.1065 TD
[(according)-294(to)-293.9(an)-292.3(organized)-294(secondary)-291.2(insult)-294.9(program.)]TJ
6.7246 0 0 5.9768 504.2833 480.1888 Tm
(19)Tj
8.9663 0 0 8.9663 513.6377 476.2203 Tm
[(ICP)-289(eleva-)]TJ
-22.3705 -1.1128 TD
[(tions)-443.1(not)-438.8(controlled)-444.6(by)-435.3(standard)-445(therapy)-438(or)-437.9(CSF)-443(drainage)-439.9(were)]TJ
T*
[(treated)-330.6(with)-319.2(pharmacologically)-329.5(induced)-321.6(coma)-322.6(using)-325.2(rst)-320.6(continu-)]TJ
0 -1.1065 TD
[(ous)-233.7(propofol)-226.6(infusions)-229.9(without)-226.9(neurological)-231(wake-up)-234.9(tests)]TJ
6.7246 0 0 5.9768 520.8943 450.3117 Tm
(20)Tj
8.9663 0 0 8.9663 529.6818 446.3432 Tm
[(and)-228.6(as)]TJ
-24.1598 -1.1128 TD
[(second-tier)-610.7(therapy,)-605.3(continuous)-607.4(sodium)-606.5(pentobarbital)-607.6(infusion)]TJ
T*
[(therapy)-286.2(and/or)-278(a)-280.1(decompressive)-287.7(craniotomy.)]TJ
/F9 1 Tf
0 -2.7505 TD
[(Imaging)-336(and)-335.7(image)-334.3(analysis)]TJ
/F4 1 Tf
1.1128 -1.7514 TD
[(An)-211(initial)-215.1(CT)-212.2(was)-207.8(performed)-214.1(on)-207.7(admission)-214.3(and)-209.6(scored)-214.4(according)]TJ
-1.1128 -1.1128 TD
[(to)-281.3(the)-283.2(Marshall)-279(classication)-285.9(by)-277.2(the)-283.2(rst)-282.7(author)-278(\(SAH\).)]TJ
6.7246 0 0 5.9768 513.014 380.0692 Tm
(8)Tj
8.9663 0 0 8.9663 518.8534 376.044 Tm
[(MRI)-284.8(was)]TJ
-22.9522 -1.1065 TD
[(performed)-271(as)-261.9(soon)-264.8(as)-268.2(the)-264.2(patients)-267.1(were)-261.7(medically)-271.4(stable.)-267(MRI)-265.8(was)]TJ
0 -1.1128 TD
[(performed)-188.8(with)-186.4(a)-185.3(1.5T)-184.6(scanner)-184.7(\(Siemens)-187.9(Avanto,)-186.8(Siemens)-185.8(Medical,)]TJ
T*
[(Erlangen,)-351.7(Germany\).)-351(Imaging)-350.6(included)-344.1(a)-349.7(gradient)-353(echo)-344.3(T2*GRE)]TJ
0 -1.1065 TD
[(sequence)-190.3(\(repetition)-185.1(time)-182.8([TR]:)-188.4(500)-162.9(msec,)-187.6(echo)-179.9(time)-189.1([TE]:)-183.4(14)-163.4(msec,)]TJ
0 -1.1128 TD
[(ip)-273(angle)-272([FA]:)-267.9(30)-270.9(degrees,)-269.8(acquisition)-269.7(voxel:)-273.1(0.9)]TJ
/F5 1 Tf
20.2586 0 TD
()Tj
/F4 1 Tf
.7145 0 TD
(0.9)Tj
/F5 1 Tf
1.4163 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
[(3)-163.9(mm\);)-271(a)]TJ
-23.1102 -1.1128 TD
[(diffusion-weighted)-290(\(DW\))-286.7(sequence)-285.2(\(SE-EPI,)-288.6(b-value)-286.3(1000)-168.8(s/mm)]TJ
6.7246 0 0 5.9768 546.5762 320.2582 Tm
(2)Tj
8.9663 0 0 8.9663 549.9211 316.2897 Tm
(,)Tj
-26.4171 -1.1128 TD
[(TR:)-272.7(4700)-168.8(msec,)-269.8(TE:)-267.7(89)-163.4(msec,)-269.8(acquisition)-276(voxel:)-266.8(1.2)]TJ
/F5 1 Tf
20.9731 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
(1.2)Tj
/F5 1 Tf
1.4163 0 TD
()Tj
/F4 1 Tf
.7145 0 TD
[(5)-170.2(mm\);)]TJ
-23.8247 -1.1065 TD
[(and)-304.5(a)-305.4(SWI)-305.1(sequence)-310.5(\(TR:)-300.1(49)-169.7(msec,)-307.7(TE:)-299.4(40)-169.7(msec,)-307.7(FA:)-301.6(15)-302.5(degrees,)]TJ
0 -1.1128 TD
[(acquisition)-288.6(voxel:)-279.4(0.9)]TJ
/F5 1 Tf
8.8963 0 TD
()Tj
/F4 1 Tf
.7145 0 TD
(0.9)Tj
/F5 1 Tf
1.4163 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
[(1.5)-166.3(mm\).)]TJ
-10.6351 -1.1128 TD
[(The)-291.6(images)-295.2(were)-293.3(assessed)-299(independently)-291.2(by)-289.9(two)-296.7(of)-286.2(the)-295.8(authors)]TJ
-1.1128 -1.1128 TD
[(\(SAH)-619.2(and)-614.3(JW\).)-614.2(DAI-associated)-619.4(lesions)-616.4(were)-615.8(dened)-613.8(as)-616(hy-)]TJ
0 -1.1065 TD
[(pointense/decreased)-252.3(signals)-243.4(for)-244(T2*GRE)-245(and)-247.5(SWI)-241.9(sequences,)-250.8(and/)]TJ
0 -1.1128 TD
[(or)-279.8(restricted)-280.1(diffusion)-281.9(for)-275.6(DW)-276.1(sequence)-285.2(in)-274.9(white)-276.9(matter)-281.6(structures)]TJ
T*
[(not)-293.4(extending)-293(to)-293.9(the)-295.8(cortex.)-289.7(No)-293.2(size)-298.9(limit)-289.1(was)-296.3(used.)-289.1(Present)-298.7(small)]TJ
0 -1.1065 TD
[(cortical)-233(lesions)-224.4(were)-230.1(excluded.)-225.3(Mimicking)-223(lesions)-230.7(such)-223(as)-223.9(vascular)]TJ
0 -1.1128 TD
[(structures)-287.5(were)-280.7(excluded)-285.6(based)-281.8(on)-277.2(tubular)-281.5(shape.)]TJ
1.1128 -1.1128 TD
[(The)-405.4(Adams)-412.7(anatomical)-406.1(histopathological)-410(grading)-410.3(system)-407.8(was)]TJ
-1.1128 -1.1128 TD
(applied.)Tj
6.7246 0 0 5.9768 341.8582 200.7496 Tm
(7)Tj
8.9663 0 0 8.9663 347.8109 196.7244 Tm
[(The)-291.6(grading)-290.2(was)-290(performed)-290(both)-286.6(for)-288.3(each)-289.8(sequence)-291.5(sep-)]TJ
-3.8759 -1.1065 TD
[(arately)-299(and)-291.8(for)-294.6(all)-293.5(MRI)-291.1(sequences)-298.5(combined,)-289.6(where)-299.2(patients)-292.4(were)]TJ
0 -1.1128 TD
[(classied)-290.1(according)-287.7(to)-287.6(the)-283.2(sequence)-291.5(giving)-283.3(the)-289.5(highest)-286.4(grade.)-286.1(The)]TJ
T*
[(number)-258.5(of)-248.2(DAI-associated)-259(lesions)-249.7(was)-258.4(counted)-252(on)-251.9(each)-251.9(side)-252.3(of)-254.5(the)]TJ
T*
[(midline)-368.7(in)-363.4(different)-370.4(anatomical)-368.1(localizations)-372.4(of)-362(the)-365.4(brain)-367(as)-369.4(pre-)]TJ
0 -1.1065 TD
[(sented)-285.3(in)-281.3(Table)-278.1(1.)]TJ
1.1128 -1.1128 TD
[(The)-481.3(mesencephalon)-488.7(was)-479.7(anatomically)-485(divided)-481.3(into)-480.3(three)-483.2(re-)]TJ
-1.1128 -1.1128 TD
[(gions;)-474.2(\(1\))-465.3(crus)-472.2(cerebri,)-471.2(\(2\))-465.3(substantia)-469.6(nigra)-468.2(and)-468.8(mesencephalic)]TJ
T*
[(tegmentum,)-480(and)-475.2(\(3\))-471.6(tectum)-475.1(including)-471.7(the)-472.9(superior)-476.8(and)-475.2(inferior)]TJ
0 -1.1065 TD
[(colliculi)-343(\(Fig.)-335(1\).)-339.7(The)-335.9(pons)-340.7(and)-336.1(the)-340.1(medulla)-335.5(oblongata)-337.3(were)-343.9(ana-)]TJ
0 -1.1128 TD
[(tomically)-228.7(divided)-222(into)-221.1(a)-223.2(ventral)-220.7(and)-222.3(a)-223.2(dorsal)-222.3(tegmental)-227.1(portion.)-218.8(For)]TJ
T*
[(practical)-336.1(reasons,)-331.8(patients)-330.3(with)]TJ
/F5 1 Tf
12.9367 0 TD
(>)Tj
/F4 1 Tf
.5564 0 TD
[(10)-327.8(lesions)-325.6(in)-331.8(one)-323.4(anatomical)-336.5(lo-)]TJ
-13.4931 -1.1065 TD
[(cation)-439.9(unilaterally)-435.1(were)-432.4(assigned)-437.3(the)-428.6(number)-435.6(15,)-431.9(similar)-435.7(to)-433(the)]TJ
0 -1.1128 TD
[(approach)-214.6(of)-210.3(an)-210.1(earlier)-213.1(study.)]TJ
6.7246 0 0 5.9768 414.255 71.2063 Tm
(17)Tj
8.9663 0 0 8.9663 422.8723 67.2378 Tm
[(Both)-209.1(raters)-214.7(were)-211.1(blinded)-209.4(to)-211.7(patients)]TJ
-12.2475 -1.1128 TD
(outcome.)Tj
/F3 1 Tf
-27.9978 77.2217 TD
(342)Tj
44.2414 0 TD
[(ABU)-337.2(HAMDEH)-333.3(ET)-338.7(AL.)]TJ
ET
endstream
endobj
75 0 obj
<>stream
/GS1 gs
BT
/F9 1 Tf
8.9663 0 0 8.9663 59.7543 326.5511 Tm
0 0 0 rg
0 Tc
0 Tw
[(Potential)-339.1(clinical)-337.2(prognostic)-333.6(predictors)]TJ
/F4 1 Tf
1.1128 -2.194 TD
[(Demographic)-236.6(data)-234.5(and)-228.6(other)-234.2(clinical)-234.4(information)-232.8(were)-236.4(collected)]TJ
-1.1128 -1.1128 TD
[(from)-329.3(the)-321.1(electronic)-329.3(patient)-329.6(record)-323.3(system,)-328.5(the)-327.4(TBI)-321.8(NIC)-331.6(database,)]TJ
0 -1.1065 TD
[(and)-386.7(the)-384.3(Uppsala)-389.3(TBI)-385(registry)-386(\(www.ucr.uu.se\).)-390(Physiologic)-388.3(data)]TJ
0 -1.1128 TD
[(were)-476.7(collected)-478.9(using)-477(a)-476.1(computerized)-479.6(multimodality)-476.2(monitoring)]TJ
T*
[(system)-667(collecting)-663.4(minute-by-minute)-664(average)-666.4(values)-664.7(for)-661.3(each)]TJ
28.0042 6.6391 TD
[(monitored)-296.7(parameter.)]TJ
6.7246 0 0 5.9768 388.7432 330.5196 Tm
(21)Tj
8.9663 0 0 8.9663 398.1542 326.5511 Tm
[(Data)-294.7(were)-299.6(manually)-297(assessed,)-295.5(and)-298.1(invalid)]TJ
-9.7373 -1.1128 TD
[(data)-228.2(were)-236.4(withdrawn)-230.3(from)-228.1(the)-232.6(total)-233.3(monitoring)-228.3(time.)-229.9(Physiological)]TJ
0 -1.1065 TD
[(data)-316.7(collection)-321.9(was)-321.6(interrupted)-326.6(when)-319.9(the)-321.1(patient)-317(was)-321.6(taken)-322.6(to)-319.2(the)]TJ
0 -1.1128 TD
[(operating)-339.9(room)-339.3(or)-336.7(for)-338.9(radiologic)-337.1(evaluation)-343.2(as)-337.7(well)-340.6(as)-337.7(when)-338.9(net-)]TJ
T*
[(work)-282.2(or)-279.8(software)-280.2(failures)-280.9(occurred.)]TJ
1.1128 -1.1128 TD
[(Th)-17.8(e)-248.5(r)0(e)21.3(m)0(a)20.3(i)0(n)15.9(i)0(n)22.2(g)-227.1(mo)16.4(n)13.1(i)0(t)18.2(o)13.1(ri)19.6(ng)-220.3(d)13.1(a)0(t)19.8(a)0(,)-219.8(a)0(f)21.2(t)0(e)13.5(r)-223.4(re)14.9(mo)22.7(va)17.5(l)-224.8(o)0(f)-216.6(i)0(n)15.9(v)13.1(al)19.8(id)-218(da)17.5(ta)-220.4(an)23.8(d)]TJ
-1.1128 -1.1065 TD
[(wi)18.9(th)22.2(ou)19.9(t)-401.9(t)0(h)15.9(e)-400.3(ga)17.5(ps)-392.2(fr)14.7(o)13.1(m)-401.4(in)15.9(te)19.8(rr)21.1(up)19.9(ti)18.2(o)13.1(n)-404.2(of)-393.6(mo)16.4(n)13.1(i)0(t)18.2(o)0(r)17.3(i)0(n)22.3(g)0(,)-394.4(g)13.1(av)17.5(e)-406.6(t)0(h)22.2(e)-406.6(g)13.1(o)0(o)19.9(d)]TJ
ET
59.754 710.135 490.167 .22681 re
f
59.754 360.17 490.167 .22678 re
f
59.754 678.387 490.167 .28345 re
f
59.754 607.294 490.167 .28345 re
f
59.754 576.113 490.167 .22681 re
f
59.754 534.898 490.167 .22675 re
f
59.754 503.66 490.167 .22678 re
f
59.754 482.4 490.167 .22678 re
f
59.754 461.14 490.167 .22675 re
f
59.754 429.902 490.167 .22678 re
f
59.754 398.664 490.167 .22678 re
f
BT
/F8 1 Tf
8.9663 0 0 8.9663 92.4094 725.7825 Tm
(Table)Tj
/F4 1 Tf
2.9971 0 TD
(1.)Tj
/F8 1 Tf
1.2519 0 TD
[(Protocol)-331.9(Used)-336.2(for)-334.6(Counting)-336.6(Lesions)-330(in)-338(Different)-336.4(Anatomical)-331.5(Localizations)-336.9(Using)-333.3(Magnetic)]TJ
5.6653 -1.1128 TD
[(Resonance)-333.4(Imaging)-338.6(in)-331.6(Patients)-333.4(with)-334.2(Diffuse)-338.5(Axonal)-331.1(Injury)]TJ
/F6 1 Tf
-13.5563 -2.3332 TD
[(Grade)-339.6(1)]TJ
0 -1.1128 TD
[(\(hemispheric\))-2985.3(T2*GRE)-3615.3(Right)-4216.5(Left)-1511.9(DW)-4152.3(Right)-4760.2(Left)-1511.9(SWI)-3613.6(Right)-4216.5(Left)]TJ
/F4 1 Tf
0 -2.0929 TD
(Frontal)Tj
0 -1.1128 TD
(Temporal)Tj
0 -1.1065 TD
(Parietal)Tj
0 -1.1128 TD
(Occipital)Tj
T*
(Insular)Tj
0 -1.1065 TD
(Cerebellar)Tj
/F6 1 Tf
0 -2.3774 TD
[(Grade)-339.6(2)-328.3(\(corpus)]TJ
0 -1.1065 TD
[(callosum\))-4553(T2*GRE)-3925.1(DW)-4474.7(SWI)]TJ
/F4 1 Tf
0 -2.3774 TD
(Genu)Tj
0 -1.1065 TD
(Body)Tj
0 -1.1128 TD
(Splenium)Tj
/F6 1 Tf
0 -2.3711 TD
[(Grade)-339.6(3)]TJ
0 -1.1128 TD
[(\(brainstem\))-3835(T2*GRE)]TJ
13.3856 1.1128 TD
(Crus)Tj
-.5248 -1.1128 TD
(cerebri)Tj
4.2364 1.1128 TD
[(SN)-338.9(and)]TJ
-.5185 -1.1128 TD
[(tegmental)-995.9(Tectal)-1039.2(DW)]TJ
12.5257 1.1128 TD
(Crus)Tj
-.5248 -1.1128 TD
(cerebri)Tj
4.2364 1.1128 TD
[(SN)-332.5(and)]TJ
-.5248 -1.1128 TD
[(tegmental)-995.9(Tectal)-1039.2(SWI)]TJ
11.552 1.1128 TD
(Crus)Tj
-.5248 -1.1128 TD
(cerebri)Tj
4.2364 1.1128 TD
[(SN)-338.9(and)]TJ
-.5185 -1.1128 TD
[(tegmental)-995.9(Tectal)]TJ
/F4 1 Tf
-47.0361 -2.3711 TD
(Mesencephalon)Tj
/F6 1 Tf
8.5423 -2.3711 TD
[(T2*GRE)-3198(Ventral)-3194.8(Dorsal)-910.9(DW)-3735(Ventral)-3744.9(Dorsal)-904.6(SWI)-3196.3(Ventral)-3194.8(Dorsal)]TJ
/F4 1 Tf
-8.5423 -2.3774 TD
(Pons)Tj
0 -1.1065 TD
[(Medulla)-338.9(oblongata)]TJ
/F6 1 Tf
0 -2.3711 TD
[(Deep)-335(hemispheric)]TJ
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(Thalamus)Tj
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[(Basal)-341.1(ganglia)]TJ
T*
[(Internal)-336.6(capsule)]TJ
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[(T2*GRE,)-327.7(T2*-weight)14.9(ed)-333.4(gradient)-324.5(echo;)-328.8(DW,)-332.8(diffusion)13.7(-weighted)-332(sequen)12(ce;)-333(SWI,)-329.4(susceptibility-)13.8(weighted)-330.7(imaging;)]TJ
ET
q
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/Im1 Do
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BT
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[(FIG.)-246.3(1.)-1001.5(\(A,)-248.1(B\))]TJ
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/F3 1 Tf
0 77.2091 TD
[(ANATOMICAL)-337.1(GRADING)-337(IN)-335.1(DIFFUSE)-338.7(AXONAL)-337.5(INJURY)-26753.9(343)]TJ
ET
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