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  • Ahrell, Natalie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Romance Languages.
    ¿Favorecen los manuales de español la comunicatividad en la escritura?: Una investigación de los ejercicios escritos en tres manualesde español 3, utilizados en los bachilleratos en Suecia2023Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    Para la enseñanza de español como ELE en Suecia, El Consejo Nacional de Educación [Skolverket] sostiene un enfoque comunicativo que se espera enmarque la enseñanza y el aprendizaje. Al mismo tiempo, los manuales constituyen muchas veces una gran parte de la enseñanza y funcionan como una garantía para los profesores de que los estudiantes tienen suficientes oportunidades para practicar las habilidades necesarias para alcanzar los objetos del curso. Por eso, es relevante investigar los manuales. El objetivo de este trabajo es analizar los ejercicios escritos en tres manuales utilizados en el curso español 3, para determinar qué oportunidades ofrecen para alcanzar el enfoque comunicativo y también para evaluar si los manuales permiten ejercitarlo. Para analizar esto, se realiza un análisis de contenido cuantitativo para encontrar la distribución de los distintos tipos de ejercicios escritos, partiendo de las categorías de Littlewood (2018:1227). Además, para determinar si los manuales permiten la práctica del enfoque comunicativo, se relaciona el análisis de contenido cuantitativo y sus resultados con una idea de Nation (2007) donde propone cuál sería la distribución ideal de los ejercicios en términos de la división del tiempo entre diferentes aspectos. Las conclusiones son que todos los manuales ofrecen principalmente ejercicios no comunicativos y, en menor medida, ejercicios que son comunicativos en diversos grados. Además, ninguno de los manuales tiene una distribución de ejercicios que permita ejercitar el enfoque comunicativo del Consejo Nacional de Educación. 

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  • Ugarte Bern, Sophie Charlotte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Codificación de la evidencialidad en el español chileno: Estrategias prosódicas con parecer2023Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the present study, the fundamental frequency (F0) or pitch of parecer ‘seem’ has been analysed through PRAAT, in statements that differ regarding the mode of access to the information (n=80), produced by Chilean informants between 24-50 years old. For the first phase of the study, statements were elicited experimentally, through the creation of different situations corresponding to indirect evidentiality, whether referred (n=40) or inferred (n=40), respectively. Additionally, a ToBi system analysis was applied to examine the final cadence of the utterances. The second phase of the study is composed of an ABX distinction experiment and an identification experiment, where the participants were asked to listen to the statements elicited in the first phase and distinguish/identify the different stimuli, belonging to different modes of access to the information. 

    The results indicate that in the pitch of parecer ‘seem’ there is an average difference of 1,967 semitones (st) between reference situations and inference situations, with the referred situations being more prominent, that is, they maintain a higher pitch. Regarding the final cadence of the statements, it was observed that a considerable majority is assertive in inference, when comparing to referred situations. Consequently, it is possible to affirm that in these cases evidentiality is distinguished through prosody. In the second phase of the study, an error rate of 23.2% was verified in the ABX distinction experiment and 29.1% in the identification experiment, which indicates that the participants are capable of distinguishing and categorizing different stimuli, as well as identifying them without previous labelling, with an error rate of less than 30% in both cases.

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  • Aljundi, Alex
    The effects of improved urine sampling on the prescription of antibiotics to children suspected of having febrile UTI2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
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  • Charalampidis, Anastasios
    et al.
    Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, S-14186 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Reconstruct Orthopaed, Stockholm, Sweden..
    Diarbakerli, Elias
    Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Reconstruct Orthopaed, Stockholm, Sweden..
    Dufvenberg, Marlene
    Linköping Univ, Unit Physiotherapy, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Jalalpour, Kourosh
    Karolinska Univ Hosp, Dept Reconstruct Orthopaed, Stockholm, Sweden..
    Ohlin, Acke
    Lund Univ, Dept Clin Sci, Clin & Mol Osteoporosis Unit, Lund, Sweden.;Skane Univ Hosp, Dept Orthopaed, Malmö, Sweden..
    Aspberg Ahl, Anna
    Ryhov Hosp, Dept Orthopaed, Jönköping, Sweden..
    Möller, Hans
    Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.;Stockholm Ctr Spine Surg, Stockholm, Sweden..
    Abbott, Allan
    Linköping Univ, Unit Physiotherapy, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ Hosp, Dept Orthopaed, Linköping, Sweden..
    Gerdhem, Paul
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics and Handsurgery. Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden; Uppsala Univ Hosp, Dept Orthoped & Hand Surg, Uppsala, Sweden.
    Nighttime Bracing or Exercise in Moderate-Grade Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial2024In: JAMA Network Open, E-ISSN 2574-3805, Vol. 7, no 1, article id e2352492Article in journal (Refereed)
    Abstract [en]

    Importance  Moderate-grade adolescent idiopathic scoliosis (AIS) may be treated with full-time bracing. For patients who reject full-time bracing, the effects of alternative, conservative interventions are unknown.

    Objective  To determine whether self-mediated physical activity combined with either nighttime bracing (NB) or scoliosis-specific exercise (SSE) is superior to a control of physical activity alone (PA) in preventing Cobb angle progression in moderate-grade AIS.

    Design, Setting, and Participants  The Conservative Treatment for Adolescent Idiopathic Scoliosis (CONTRAIS) randomized clinical trial was conducted from January 10, 2013, through October 23, 2018, in 6 public hospitals across Sweden. Male and female children and adolescents aged 9 to 17 years with an AIS primary curve Cobb angle of 25° to 40°, apex T7 or caudal, and skeletal immaturity based on estimated remaining growth of at least 1 year were included in the study. Dates of analysis were from October 25, 2021, to January 28, 2023.

    Interventions  Interventions included self-mediated physical activity in combination with either NB or SSE or PA (control). Patients with treatment failure were given the option to transition to a full-time brace until skeletal maturity.

    Main Outcomes and Measures  The primary outcome was curve progression of 6° or less (treatment success) or curve progression of more than 6° (treatment failure) seen on 2 consecutive posteroanterior standing radiographs compared with the inclusion radiograph before skeletal maturity. A secondary outcome of curve progression was the number of patients undergoing surgery up until 2 years after the primary outcome.

    Results  The CONTRAIS study included 135 patients (45 in each of the 3 groups) with a mean (SD) age of 12.7 (1.4) years; 111 (82%) were female. Treatment success was seen in 34 of 45 patients (76%) in the NB group and in 24 of 45 patients (53%) in the PA group (odds ratio [OR], 2.7; 95% CI, 1.1-6.6). The number needed to treat to prevent curve progression with NB was 4.5 (95% CI, 2.4-33.5). Treatment success occurred in 26 of 45 patients (58%) in the SSE group (OR for SE vs PA, 1.2; 95% CI, 0.5-2.8). Up to 2 years after the primary outcome time point, 9 patients in each of the 3 groups underwent surgery.

    Conclusions and Relevance  In this randomized clinical trial, treatment with NB prevented curve progression of more than 6° to a significantly higher extent than did PA, while SSE did not; in addition, allowing transition to full-time bracing after treatment failure resulted in similar surgical frequencies independent of initial treatment. These results suggest that NB may be an effective alternative intervention in patients rejecting full-time bracing.

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  • Public defence: 2024-03-15 13:00 A1:111a, Uppsala
    De Tarafder, Arindam
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
    Adaptive Evolution of the Bacterial Translation Machinery2024Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The process of protein synthesis via translation is of paramount importance for the existence of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion years of molecular evolution to adapt and function efficiently under the provided physiological conditions. This thesis dwells on the intricacies of the adaptive evolution, which the massively complex translation machinery has undergone to function optimally in diverse conditions and habitats. In Paper I, we used elongation factor Tu (EF-Tu) as a model system to follow the evolution of ribosome specificity in translation factors. For that, we have biochemically characterized two sequence-reconstructed ancestral EF-Tu variants for their specificities towards two unrelated extant bacterial ribosomes, mesophilic Escherichia coli and thermophilic Thermus thermophilus. Our fast kinetics-based biochemical analysis hints at the ‘generalist’ ancestry of modern EF-Tu proteins. In Paper II, we have reconstituted an in vitro translation system of the psychrotolerant bacteria Pseudoalteromonas haloplanktis to quantitatively characterize the steps of translation elongation. Our results demonstrate similar kinetics of peptide bond formation in psychrotolerant P. haloplanktis and mesophilic E. coli. In contrast, P. haloplanktis ribosome exhibits much slower rates of EF-G-catalyzed tRNA translocation than E. coli. Comparison and swapping of the EF-Gs and tRNAs between the two in vitro translation systems indicate that the slow translocation is likely an inherent property of the P. haloplanktis ribosome. Furthermore, our results demonstrate the varied extent of antibiotic inhibition on the P. haloplanktis minimal translation system, particularly when targeting processes related to translocation and peptide bond formation, compared to E. coli. In Paper III, we used ribosomes from bacterial species of diverse habitats to show that the ribosomes in vitro can maintain their catalytic activity beyond the survival temperature cutoff of the native host. Moreover, our results indicate that the thermostability of essential translation factors, EF-Tu and EF-G, dictates the upper limit of reaction temperature for translation elongation. Finally, we demonstrate that ribosomes from a psychrophile, mesophile, and thermophile can function in a vast temperature range of 10-70 °C, provided the translation factors remain structurally and functionally stable. Our results highlight the thermal versatility of the ribosome and reiterate the early emergence of a thermostable ribosomal core in the primordial RNA world.

    The outcome of this thesis will unveil some of the intricate mechanisms underlying the evolution of bacterial translation machinery. This knowledge may open up new research avenues regarding the emergence and diversification of bacteria and the development of new therapeutic strategies.

    List of papers
    1. Kinetic Analysis Suggests Evolution of Ribosome Snecificity in Modern Elongation Factor-Tus from "Generalist" Ancestors
    Open this publication in new window or tab >>Kinetic Analysis Suggests Evolution of Ribosome Snecificity in Modern Elongation Factor-Tus from "Generalist" Ancestors
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    2021 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 38, no 8, p. 3436-3444Article in journal (Refereed) Published
    Abstract [en]

    It has been hypothesized that early enzymes are more promiscuous than their extant orthologs. Whether or not this hypothesis applies to the translation machinery, the oldest molecular machine of life, is not known. Efficient protein synthesis relies on a cascade of specific interactions between the ribosome and the translation factors. Here, using elongation factor-Tu (EF-Tu) as a model system, we have explored the evolution of ribosome specificity in translation factors. Employing presteady state fast kinetics using quench flow, we have quantitatively characterized the specificity of two sequence-reconstructed 1.3- to 3.3-Gy-old ancestral EF-Tus toward two unrelated bacterial ribosomes, mesophilic Escherichia coil and thermophilic Thermus thermophilus. Although the modern EF-Tus show clear preference for their respective ribosomes, the ancestral EF-Tus show similar specificity for diverse ribosomes. In addition, despite increase in the catalytic activity with temperature, the ribosome specificity of the thermophilic EF-Tus remains virtually unchanged. Our kinetic analysis thus suggests that EF-Tu proteins likely evolved from the catalytically promiscuous, "generalist" ancestors. Furthermore, compatibility of diverse ribosomes with the modern and ancestral EF-Tus suggests that the ribosomal core probably evolved before the diversification of the EF-Tus. This study thus provides important insights regarding the evolution of modern translation machinery.

    Place, publisher, year, edition, pages
    Oxford University Press, 2021
    Keywords
    translation machinery, molecular evolution, EF-Tu, generalist, ancestral sequence reconstruction, fast kinetics, specificity
    National Category
    Biochemistry and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-456489 (URN)10.1093/molbev/msab114 (DOI)000693740300027 ()33871630 (PubMedID)
    Funder
    Swedish Research Council, 2016-06264Swedish Research Council, 2018-05946Swedish Research Council, 2018-05498Knut and Alice Wallenberg Foundation, KAW 2017.0055Carl Tryggers foundation , CTS 18:338
    Available from: 2021-10-19 Created: 2021-10-19 Last updated: 2024-01-29
    2. Kinetic characterization of elongation and antibiotic action in a minimal translation system of the psychrotolerant bacteria Pseudoalteromonas haloplanktis
    Open this publication in new window or tab >>Kinetic characterization of elongation and antibiotic action in a minimal translation system of the psychrotolerant bacteria Pseudoalteromonas haloplanktis
    (English)Manuscript (preprint) (Other academic)
    Keywords
    translation, cold bacteria, translocation, antibiotics, peptide bond
    National Category
    Biochemistry and Molecular Biology
    Research subject
    Biochemistry; Molecular Life Sciences
    Identifiers
    urn:nbn:se:uu:diva-521884 (URN)
    Available from: 2024-01-29 Created: 2024-01-29 Last updated: 2024-01-29
    3. Functional conservation of ribosomal activity across temperatures and species
    Open this publication in new window or tab >>Functional conservation of ribosomal activity across temperatures and species
    (English)Manuscript (preprint) (Other academic)
    National Category
    Biochemistry and Molecular Biology
    Research subject
    Molecular Life Sciences; Biochemistry
    Identifiers
    urn:nbn:se:uu:diva-521886 (URN)
    Available from: 2024-01-29 Created: 2024-01-29 Last updated: 2024-01-29
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  • Zahkung, Tu Mai
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering.
    A Local Community Perspective on the Socio-Economic andEnvironmental Impacts of Emerging Tourism Destination: ACase Study of Goyangyi Island, Myanmar2023Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Tourism has significant economic, physical, and social impacts. Goyangyi Island, asmall island situated along the south west coast of Myanmar, has rapidly gainedpopularity among domestic travelers due to its distinct, pristine, and untouchednatural scenery. The development of tourism in the area has provided jobopportunities and increased income for the local community. However, therehas been no previous research conducted on the impact of tourism on thisdestination. Through the qualitative study, perception of local community on thesocio-economic and environmental impact of tourism on the destination wasexplored. The findings show that local people are supportive of the developmentof tourism in their area as they see that there is more benefit than cost to thecommunity. Meanwhile, prevailing political situation, which lacks effectivegovernance and management for the destination, also pose challenges for thelocal community in sustaining their tourism activities. Thestudy also suggests localcommunity to engage and work together with other stakeholders for thesustainable development of the destination. 

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  • Melander, Jenny
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering.
    How can Trust-Based Public Management Influence Sustainable Destination Development?: A case study of Vadstena, Sweden2023Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Tourism is a fragmented industry with multiple stakeholders and often occurs in an area with unique characteristics. Therefore, in order to ensure that management and development strategies are suitable and sustainable for the area and its stakeholders, collaboration and involvement have been identified as essential aspects. In order to increase and maintain collaboration and involvement, it is vital first to understand the stakeholders’ situation. Then it is important to understand challenges and opportunities for developing collaboration and involvement so that coherent strategies can be implemented amongst the stakeholders and lead to increased effort towards sustainability. This study used written and semi-structured interviews to examine the tourism business situation in Vadstena, Sweden. The principles and philosophy of Trust-Based Public Management were used to provide an overview of the collected dataset and link it to the amount of trust currently present within the tourism businesses in Vadstena. The result showed that not all of the participating tourism businesses are collaborating with each other or the municipality, which is the primary developer and manager of Vadstena. The result of this study showed that not all tourism businesses collaborate nor trust Vadstena municipality. Therefore, the study concluded that there is a need to involve tourism businesses more in the development and management strategies. The study also concluded that there is a need to implement common goals, especially for sustainable development in Vadstena, Sweden.

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  • Hedengrahn, Alexandra
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering.
    Building ecological knowledge among children with nature as a playground: A suggestion for a recreational and educational nature trail for children in Aränge, Gotland2023Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Modern society is faced with an increasing level of environmental degradation. One effect of this is the loss of possibilities for children to interact with natural environments. Children’s interactions with nature come with a wide range of benefits, both physical and psychological, accentuating the need to develop outdoor spaces for children in areas of preserved nature. One way to approach this challenge is by developing recreational and educational nature trails aimed at children. Länsstyrelsen Gotland (the county administrative board) requested a theoretical suggestion for a children’s nature trail in a prospective nature reserve in Gotland and this study was done to bring forth such a suggestion. The study focused on what educational and recreational elements would be suitable to include in a nature trail for children and how to build ecological knowledge among its visitors in effective and creative ways. The material for this study was collected through semi-structured interviews with children’s caregivers and educators in combination with observations at existing nature trails for children using a geosemiotic approach. The results were analysed through a thematic analysis that extracted four main themes from the two sets of data with sub-themes to broaden the results. The themes and sub-themes were used to highlight elements suitable to include at the stations in terms of activities and layout of the trail, and how to get and keep children’s attention along the trail. A suggestion for a nature trail for children with eight stations was put together, steeped in the non-consumptive standards of ecotourism and with a clear focus on getting the visitors to learn about nature, especially through the framework of ecological literacy. Fun and play were seen as essential components to effectively build ecological knowledge and it is argued that perhaps the objects and activities provided at built-up ecotourism sites are necessary to get more people to visit nature in the first place.

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  • Ardner, Matilda
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering.
    Sustainable Entrepreneurial Ecosystems in Rural Areas:: Exploring the Motivations and Decision-Making Processes of Lifestyle Entrepreneurs in Promoting Sustainability and Cooperation in Tourism2023Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Rural areas have experienced a decline in traditional livelihoods, leading to a decrease in population and economic challenges. However, tourism has emerged as a crucial source of income and a driving force in rural community development. This study explores the role of lifestyle entrepreneurs in creating sustainable entrepreneurial ecosystems in rural tourism destinations. It investigates the motivations and management practices of lifestyle entrepreneurs and examines their perceptions of their own performance and contribution to sustainable entrepreneurial ecosystems in their local communities. Six in-depth interviews were conducted with lifestyle entrepreneurs operating in different regions of rural Sweden to address the research questions. 

     

    The findings reveal that lifestyle entrepreneurs are primarily motivated by the quality of life, personal fulfilment, creativity, autonomy, and a strong connection to their community and local environment. These motivations influence their decision-making processes, leading to the application of sustainable business practices that align with their values. Networking and cooperation among lifestyle entrepreneurs are emphasized, with a focus on collaboration over competition, resulting in benefits such as sustainable practices, increased competitiveness, and opportunities for knowledge sharing and discussion. However, the extent of engagement in networking and cooperation may vary based on entrepreneurs' motivations and priorities.

     

    The study concludes that promoting sustainable tourism practices and supporting the well-being of lifestyle entrepreneurs are crucial for local sustainable development. Policymakers and stakeholders should consider the unique needs of lifestyle entrepreneurs and foster a supportive environment that encourages cooperation, networking, and work-life balance.

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  • Russell, Beth
    et al.
    Kings Coll London, Sch Canc & Pharmaceut Sci, Dept Translat Oncol & Urol Res, London, England..
    Häggström, Christel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden..
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Kings Coll London, Sch Canc & Pharmaceut Sci, Dept Translat Oncol & Urol Res, London, England..
    Liedberg, Fredrik
    Skane Univ Hosp, Dept Urol, Malmö, Sweden.;Lund Univ, Inst Translat Med, Malmö, Sweden..
    Gårdmark, Truls
    Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden..
    Bryan, Richard T.
    Univ Birmingham, Inst Canc & Genom Sci, Birmingham, England..
    Kumar, Pardeep
    Royal Marsden NHS Fdn Trust, London, England..
    Van Hemelrijck, Mieke
    Kings Coll London, Sch Canc & Pharmaceut Sci, Dept Translat Oncol & Urol Res, London, England..
    Systematic review of the association between socioeconomic status and bladder cancer survival with hospital type, comorbidities, and treatment delay as mediators2021In: BJUI Compass, E-ISSN 2688-4526, Vol. 2, no 3, p. 140-158Article, review/survey (Refereed)
    Abstract [en]

    ObjectivesTo review the current evidence on the relationship between three proposed mediators (comorbidities, hospital type, and treatment delays) for the relationship between socioeconomic status (SES) and bladder cancer survival.Materials and methodsSix different searches using OVID (Medline and Embase) were carried out to collate information available between the proposed mediators with both SES and survival in bladder cancer. This systematic review was conducted according to a pre-defined protocol and in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsA total of 49 studies were included in the review across the six searches (one appeared in two searches). There was a wealth of studies investigating the relationship between each of the proposed mediators with survival in bladder cancer patients. In general, a higher SES, lower comorbidities, and a larger hospital volume were all found to be associated with a decreased risk of death in bladder cancer patients. There was, however, a paucity of studies investigating the associations between these mediators and SES in bladder cancer patients.ConclusionsTo gain a deeper understanding of the relationship between SES and survival identified in several observational studies, further investigations into the relationship between the proposed mediators and SES are warranted. Moreover, modifiable mediators, eg, treatment delay, highlight the importance of the standardization of clinical care across SES groups for all bladder cancer patients.

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  • Pergolizzi, Joseph
    et al.
    Native Cardio Inc, Cardiol, Naples, FL 34108 USA..
    Varrassi, Giustino
    Paolo Procacci Fdn, Res, Rome, Italy..
    Lequang, Jo Ann K.
    NEMA Res Inc, Pain Management, Naples, FL 34108 USA..
    Breve, Frank
    Temple Univ, Pharm, Philadelphia, PA USA..
    Magnusson, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Research and Development, Gävleborg. Örebro Univ, Sch Med, Örebro, Sweden.;Karolinska Inst, Med & Cardiol Res Unit, Stockholm, Sweden..
    Fixed Dose Versus Loose Dose: Analgesic Combinations2023In: Cureus, E-ISSN 2168-8184, Vol. 15, no 1, article id e33320Article, review/survey (Refereed)
    Abstract [en]

    Combinations of drugs may be fixed (two or more entities in a single product) or loose (two or more agents taken together but as individual agents) to help address multimechanistic pain. The use of opioids plus nonopioids can result in lower opioid consumption without sacrificing analgesic benefits. Drug combinations may offer additive or synergistic benefits. A variety of fixed-dose combination products are available on the market such as diclofenac plus thiocolchicoside, acetaminophen and caffeine, acetaminophen and opioid, ibuprofen and acetaminophen, tramadol and acetaminophen, and others. Fixeddose combination products offer predictable pharmacokinetics and pharmacodynamics, known adverse events, and can reduce the pill burden. However, they are limited to certain drug combinations and doses; loose dosing allows prescribers the versatility to meet individual patient requirements as well as the ability to titrate as needed. Not all drug combinations offer synergistic benefits, which depend on the drugs and their doses. Certain drugs offer dual mechanisms of action in a single molecule, such as tapentadol, and these may further be used in combination with other analgesics. New technology allows for co-crystal productions of analgesic agents which may further improve drug characteristics, such as bioavailability. Combination analgesics are important additions to the analgesic armamentarium and may offer important benefits at lower doses than monotherapy.

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    FULLTEXT01
  • Kopp, Alexander
    et al.
    Meotec GmbH, D-52068 Aachen, Germany..
    Werner, Jonas
    Cent Facil Electron Microscopy RWTH Aachen, D-52074 Aachen, Germany..
    Kröger, Nadja
    Rhein Westfal TH Aachen, Inst Lab Anim Sci & Expt Surg, Fac Med, D-52074 Aachen, Germany.;St Antonius Hosp Eschweiler, Clin Plast & Aesthet Surg Hand & Reconstruct Surg, D-52249 Eschweiler, Germany..
    Weirich, Thomas E.
    Cent Facil Electron Microscopy RWTH Aachen, D-52074 Aachen, Germany..
    D'Elia, Francesco
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering. Meotec GmbH, D-52068 Aachen, Germany.
    Combined severe plastic deformation processing of commercial purity titanium enables superior fatigue resistance for next generation implants2024In: Biomaterials Advances, ISSN 2772-9516, Vol. 157, article id 213756Article in journal (Refereed)
    Abstract [en]

    Commercial purity titanium (cp-Ti) is considered for replacing Ti64 as an implant material in various applications, due to the potential toxicity associated with the release of Al and V ions. However, the mechanical properties of cp-Ti, particularly fatigue resistance, are inadequate for this purpose. In this study, cp-Ti grade 4 rods were processed using a combination of equal channel angular pressing and rotary swaging (ECAP/RS). Tensile and fatigue tests were conducted, along with detailed microscopy and evaluation of corrosion resistance and biocompatibility. An average yield strength of 1383 MPa was obtained while maintaining moderate ductility of 10 %. This represents the highest strength ever recorded for cp-Ti, even exceeding that of Ti64. Additionally, fatigue endurance limit increased by 43 % up to 600 MPa, almost obtaining that of Ti64. Strengthening mechanisms were attributed to the ultrafine-grained (UFG) microstructure generated by ECAP/RS, along with strong crystallographic texture and formation of sub-grain structure. Furthermore, the corrosion resistance and biocompatibility of cp-Ti were largely unaffected, potentially easing regulatory transition in future medical devices. Thus, these results demonstrate high potential of combined ECAP/RS processing to manufacture UFG cpTi grade 4 materials that prospectively allow for the substitution of questionable alloys and downsizing of medical implants.

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  • Fernández Mestre, Clàudia
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Drivers of flower size evolution in the selfing species Arabidopsis thaliana2023Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    The influence of pollinators on the evolution of flower morphology has been extensively explored. Yet, the effect of other ecological factors, such as genetic drift, environmental filtering, and allometric constraints, gained less attention. In this study, we addressed the importance of those drivers in a predominantly selfing species. 400 worldwide Arabidopsis thaliana accessions were gathered and grown in semi-controlled climatic settings to explore the association between flower organ size, genotypes, and habitats. In our dataset, petal area was the most variable trait. Petal size was phenotypically and genetically correlated with other flowering structures, but no genetic allometry constraints were found to affect petal size evolution. The negative correlation of petal size with fitness and the traces of selective constraints in petal associated genes suggest that petal size is currently under selection in this species. We found paucity of genotypes harbouring large petals at low suitability regions, which points to the presence of environmental filtering. The novelty of this project relies on the pluralistic integration of factors studied and highlights the role of the climate on flower size evolution. Our results suggest that resource allocation is an important driver of flower size evolution in self-fertilising species but that its effect is largely determined by local environmental pressures.

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    Popular Science
    The full text will be freely available from 2025-02-22 12:00
  • Cassia, Luca
    et al.
    Univ Melbourne Parkville, Sch Math & Stat, Melbourne, Vic 3010, Australia..
    Posch, Vera
    Trinity Coll Dublin, Sch Math, Dublin, Ireland.;Trinity Coll Dublin, Hamilton Math Inst, Dublin, Ireland..
    Zabzine, Maxim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    β-Ensembles and higher genera Catalan numbers2024In: Letters in Mathematical Physics, ISSN 0377-9017, E-ISSN 1573-0530, Vol. 114, no 1, article id 26Article in journal (Refereed)
    Abstract [en]

    We propose formulas for the large N expansion of the generating function of connected correlators of the β-deformed Gaussian and Wishart–Laguerre matrix models. We show that our proposal satisfies the known transformation properties under the exchange of β with 1 / β and, using Virasoro constraints, we derive a recursion formula for the coefficients of the expansion. In the undeformed limit β = 1, these coefficients are integers and they have the combinatorial interpretation of generalized Catalan numbers. For generic β, we define the higher genus Catalan polynomials Cg,v(β) whose coefficients are integer numbers. 

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  • Murauskaité, Urté
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Speech-Language Pathology.
    Vocal Requirements on the Swedish Labour Market: A cross-sectional descriptive survey study2024Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    It is estimated that approximately one third of the labour market consists of vocally demanding occupations, namely occupations where the voice is an important and necessary tool to execute one’s work. Previous research has identified teachers, singers, and priests as occupations with vocally demanding work. However, the research is over 20 years old, and current research about vocal requirements on the labour market, especially amongst groups that are not overrepresented regarding voice problem, are missing. The purpose of this study is to identify which vocal requirements are essential on the modern Swedish labour market. A total of 477 participants completed a survey with questions about estimated speaking time during a workday, as well as which vocally demanding work tasks and vocally challenging work environmental factors occured at their workplace. The result from the descriptive cross-sectional study shows that several occupations that previously have been identified as vocally demanding occupations, also are vocally demanding occupations today. Further identified occupations in this study were employees working within libraries and museums, nursing professionals with continued education such as pediatric nurses, education managers, and the occupational group “authors, journalists, and interpreters”. The most occurring vocal demands in the Swedish labour market today were verbally instructing or informing colleagues, speaking on the phone, and verbally communicating with customers/clients/patients/users/visitors. Further research with a larger number of participants is needed to identify vocally demanding occupational groups and vocal requirements on the modern Swedish labour market, where the voice is expected to last during an increasing amount of working years.

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  • Suleman, Sherzad
    et al.
    Witten Herdecke Univ, Fac Hlth Sci, Nursing Dept, Witten, Germany.;Witten Herdecke Univ, Hlth Sci Nursing, Dept Nursing Sci, Witten, Germany.;Witten Herdecke Univ, Fac Hlth Sci, Dept Nursing Sci, Wasser Str 8, D-58455 Witten, Germany..
    Halek, Margareta
    Witten Herdecke Univ, Fac Hlth, Dept Nursing Sci, Witten, Germany..
    Enskär, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatric oncology research with a special focus on side effects.
    Atrushi, Akram
    Univ Duhok, Coll Med, Duhok, Iraq..
    Nilsson, Stefan
    Univ Gothenburg, Inst Hlth & Caring Sci, Gothenburg, Sweden..
    A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures2023In: Pielegniarstwo XXI wieku / Nursing in the 21st Century, ISSN 1730-1912, Vol. 22, no 4, p. 264-272Article, review/survey (Refereed)
    Abstract [en]

    Aim. This study aimed to investigate whether arts-based interventions are effective in reducing the pain and anxiety of children during venipuncture.Material and methods. Our search involved 9 databases, including Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, Scopus, MEDLINE, EMBASE via PsycINFO, LILACS, ERIC, Web of Science, Google Scholar, and Dissertation Abstracts International until 31 December 2021. Clinical trials in humans published in English randomized or non-randomized were the main criteria for eligibility.Results. We included five RCTs in our review and all were included in our meta-analysis. Quantitative analysis of different clinical parameters was described. In the art-based intervention compared with the control group in terms of reduction in pain mean deviation was -0.68; 95% confidence interval: -1.14, -0.22), whereas the art-based intervention compared with the control group in terms of anxiety reduction mean deviation: -0.78; 95% confidence interval: -1.47, -0.09) during venipuncture procedures.Conclusions. In this study, art-based interventions were found to be effective for children undergoing venipuncture. However, most studies have a high risk of bias and are of low quality, so the results cannot be generalized.

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  • Wainaina, Martin
    et al.
    German Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany.;Free Univ Berlin, Dept Vet Med, Berlin, Germany.;Int Livestock Res Inst ILRI, Nairobi, Kenya..
    Vey da Silva, David Attuy
    German Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany.;Free Univ Berlin, Dept Vet Med, Berlin, Germany..
    Dohoo, Ian
    Univ Prince Edward Isl, Charlottetown, PE, Canada..
    Mayer-Scholl, Anne
    German Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany..
    Roesel, Kristina
    Free Univ Berlin, Dept Vet Med, Berlin, Germany.;Int Livestock Res Inst ILRI, Nairobi, Kenya..
    Hofreuter, Dirk
    German Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany..
    Roesler, Uwe
    Free Univ Berlin, Inst Anim Hyg & Environm Hlth, Berlin, Germany..
    Lindahl, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Int Livestock Res Inst ILRI, Nairobi, Kenya.;Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden..
    Bett, Bernard
    Int Livestock Res Inst ILRI, Nairobi, Kenya..
    Al Dahouk, Sascha
    German Fed Inst Risk Assessment, Dept Biol Safety, Berlin, Germany.;RWTH Aachen Univ Hosp, Dept Internal Med, Aachen, Germany..
    A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa2022In: PLoS Neglected Tropical Diseases, ISSN 1935-2727, E-ISSN 1935-2735, Vol. 16, no 1, article id e0010144Article, review/survey (Refereed)
    Abstract [en]

    Background

    The awareness of non-malarial febrile illnesses (NMFIs) has been on the rise over the last decades. Therefore, we undertook a systematic literature review and meta-analysis of causative agents of non-malarial fevers on the African continent.

    Methodology

    We searched for literature in African Journals Online, EMBASE, PubMed, Scopus, and Web of Science databases to identify aetiologic agents that had been reported and to determine summary estimates of the proportional morbidity rates (PMr) associated with these pathogens among fever patients.

    Findings

    A total of 133 studies comprising 391,835 patients from 25 of the 54 African countries were eligible. A wide array of aetiologic agents were described with considerable regional differences among the leading agents. Overall, bacterial pathogens tested from blood samples accounted for the largest proportion. The summary estimates from the meta-analysis were low for most of the agents. This may have resulted from a true low prevalence of the agents, the failure to test for many agents or the low sensitivity of the diagnostic methods applied. Our meta-regression analysis of study and population variables showed that diagnostic methods determined the PMr estimates of typhoidal Salmonella and Dengue virus. An increase in the PMr of Klebsiella spp. infections was observed over time. Furthermore, the status of patients as either inpatient or outpatient predicted the PMr of Haemophilus spp. infections.

    Conclusion

    The small number of epidemiological studies and the variety of NMFI agents on the African continent emphasizes the need for harmonized studies with larger sample sizes. In particular, diagnostic procedures for NMFIs should be standardized to facilitate comparability of study results and to improve future meta-analyses. Reliable NMFI burden estimates will inform regional public health strategies.

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  • Mallhi, Tauqeer Hussain
    et al.
    Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka, Saudi Arabia..
    Salman, Muhammad
    Lahore Coll Women Univ, Inst Pharm, Fac Pharmaceut & Allied Hlth Sci, Lahore, Pakistan..
    Khan, Yusra Habib
    Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka, Saudi Arabia..
    Khan, Faiz Ullah
    Xian Jiaotong Univ Xian, Sch Pharm, Dept Pharm Adm & Clin Pharm, Xian, Peoples R China..
    Butt, Muhammad Hammad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Ung, Carolina Oi Lam
    Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China..
    Khan, Amjad
    Quaid I Azam Univ, Dept Pharm, Islamabad, Pakistan..
    Aftab, Raja Ahsan
    Univ Malaya, Fac Pharm, Dept Clin Pharm & Pharm Practice, Kuala Lumpur, Malaysia..
    Editorial: Childhood vaccination and COVID-192023In: Frontiers in Pediatrics , E-ISSN 2296-2360, Vol. 11, article id 1298691Article in journal (Other academic)
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  • Johansson, Elin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Utökade möjligheter att använda preventiva tvångsmedel: Ett rättssäkert förfarande som upprätthåller skyddet för den personliga integriteten?2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
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  • Gustafsson, Fanny
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Ett mellanrum i staden: En antropologisk observationsstudie av tunnelbanan som liminalt rum och icke-plats2023Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this essay is to study patterns in peoples behaviour in the subway. I analyse the subway as a liminal space and a non-place. Through ethnographic observations in the subway in Stockholm, and with the use of sensory autoethnography and rhythm analysis, I have gathered my data. I argue that there are two things that make the subway a liminal space and a non-place: the physical design of the room, and the norms that the people on the subway create and maintain. By analysing the rhythms of the subway I show that people sustain a collective rhythmic order by adapting and coordinating their behaviour. It is physically a neutral room and does not provide anything to do other than to sit or stand and wait. It is an in-between-space that people only pass through. With the use of technology, such as mobile phones and headphones, passengers can mentally disengage from the subway. The norm of the subway is to be indifferent towards each other and towards the space. By complying with these rules, passengers create a specific sort of community, an anti-communitas. Sellers, beggars and can collectors break these rules by interacting with the surroundings and by not utilising the subway as a space for transit. By using it as a place, they are using it incorrectly. The subway is a peculiar space with specific norms that, when followed, create a liminal space and a non-place. 

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  • Grahn, Agnes
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Att fråga en kvinna om hennes ålder: En antropologisk studie av ålder och att åldras2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med uppsatsen är att undersöka hur olika föreställningar kring ålder och åldrande ser ut bland kvinnor i trettioårsåldern i Stockholm. Uppsatsen baseras på fyra stycken intervjuer som har analyserats med hjälp av teorier och begrepp som performativitet och livsmanus. Resultatet visar på att ålder ges mening genom interaktion, handlingar och ord samt att informanterna uppfattar ett livsmanus, men förhåller sig på olika sätt till det. Att avvika från livsmanuset kan få konsekvenser och hur stora de blir beror på vilka sammanhang man befinner sig i. Det kan även leda till stress och ångest hos den egna individen, men behöver inte nödvändigtvis vara så. Hur man själv och andra uppfattar ens egen ålder kan påverkas av sammanhang, situation och livsstil. Det framkom även föreställningar om tjugoårsåldern som en fri och tillåtande period som till skillnad från trettioårsåldern kommer utan en förväntan på att fatta några större beslut, agera ansvarsfullt och “veta”. Resultatet visar även på att ansvar förväntas öka i takt med åldern samt en komplexitet i att åldrande både kan förknippas med förfall och förlust samtidigt som utveckling och ökad erfarenhet. 

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  • Dahlen, Torsten
    et al.
    Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden..
    Flygt, Hjalmar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Lubking, Anna
    Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden..
    Olsson-Strömberg, Ulla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Wennstrom, Lovisa
    Sahlgrens Univ Hosp, Sect Hematol, Gothenburg, Sweden..
    Dreimane, Arta
    Linköping Univ Hosp, Dept Hematol, Linköping, Sweden..
    Sjalander, Anders
    Umeå Univ, Dept Publ Hlth & Clin Med, Sundsvall, Sweden..
    Leach, Susannah
    Sahlgrens Univ Hosp, Dept Clin Pharmacol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Microbiol & Immunol, Inst Biomed, Gothenburg, Sweden..
    Gisslen, Magnus
    Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Infect Dis, Reg Vastra Gotaland, Gothenburg, Sweden..
    Li, Huiqi
    Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden..
    Höglund, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Stenke, Leif
    Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden..
    Nyberg, Fredrik
    Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden..
    The impact of Covid-19 in patients with chronic myeloid leukemia: a nationwide population-based study2023In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 37, no 5, p. 1156-1159Article in journal (Other academic)
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  • Burman, Östen
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Stenström, Victor
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Redovisningsstandardens betydelse för resultatmanipulation2023Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie syftar till att undersöka skillnader i förekomsten av resultatmanipulation mellan den internationella redovisningsstandarden IFRS och huvudregelverket inom K-regelverken, K3. Studiens hypotes är att företag som tillämpar IFRS, som har mer vägledning och mer omfattande upplysningskrav än K3, uppvisar lägre grad av resultatmanipulation. Resultatmanipulation mäts av studien primärt genom en regressionsanalys, vilket ger ett mått på diskretionära periodiseringar vars resultat testas mellan de olika redovisningsstandarderna. Sekundärt undersöks resultatmanipulation genom visualisering av företagens önskan att slå uppsatta mål i histogramform. Vidare testas asymmetrin i histogrammens staplar kring gränsvärdena för att testa förekomsten av resultatmanipulation via target beating. Resultaten indikerar på att företag som redovisar enligt K3 resultatmanipulerar mer än företag som redovisar enligt IFRS. 

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  • Lindberg, Sofia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Persson, Ella
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Marknadsföringsbyrån i digital förändring: En kvalitativ studie om hur digital teknologi påverkar affärsrelationen mellan marknadsföringsbyrå och kund2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den digitala teknologins inverkan på affärsrelationer har främst studerats inom tillverkningsindustrin och det finns begränsad forskning om ämnet inom andra branscher. En bransch som influerats mycket av digital teknologi är marknadsföringsbranschen där marknadsföringsbyrån och kunden är centrala aktörer. Syftet med denna uppsats är att få en fördjupad förståelse för hur ny digital teknologi, i form av artificiell intelligens (AI), påverkar affärsrelationen mellan marknadsföringsbyrå och kund. Det teoretiska ramverket berör affärsrelationer, digital teknologi och dess påverkan på affärsrelationer samt affärsrelationen mellan marknadsföringsbyrå och kund. En kvalitativ metod har använts i form av semistrukturerade intervjuer med fyra marknadsföringsbyråer. Slutsatsen är att öppen kommunikation och byråns resurser i form av kunskap blir allt viktigare i affärsrelationen i samband med ny digital teknologi. Införandet av en ny digital teknologi resulterar även i att det krävs mer drastiska anpassningar av resurser som påverkar beroendet i affärsrelationen mellan marknadsföringsbyrå och kund. 

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  • Thurell, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Kungsörnen och vindkraften: En konflikt som kan lösas?2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Omställningen till förnybar energi går fort, vindkraften har utvecklats snabbt i Sverige desenaste åren. Vindkraftsanläggningar har effekt på omgivande fågelliv såsom förändring avbiotoper, bullerstörningar och risk för kollision med rotorblad. Uppsatsen undersöker vilkafaktorer som styr kungsörnens rörelsemönster, samt vilken effekt vindkraften har på kungsörnen,biotoper, födoval och häckning. Kan vindkraft och kungsörn kombineras i ett område?Exempel finns på dåligt placerade vindkraftverk, vilka har skördat många fågelliv, orsakadeav kollisioner med rotorblad, här är det inte bara rovfåglar utan också andra fågelarter somutsätts för risker.Kungsörnen är en känslig art som har uppmärksammats vid miljöprövningar inför vindkraftsbyggen.Kungsörnen har långsam reproduktion, men också att den är beroende av just debiotoper som hotas och förändras vid en större utbyggnad av vindkraft. Kungsörnen i Sverigebygger bon på klipphyllor eller i äldre skog med branter, miljöer som ofta är potentiellaområden för vindkraftsparker. Kungsörnen rör sig över stora hemområden, områdenas storlekberor på hur tät skogen är och om det finns gamla bo-träd. Kungsörnen jagar på öppna ytorsom kalhyggen, men den föredrar en kombination av gammal skog och kalhyggen.För att skydda kungsörnen vid vindkraftsetablering, kan verken etableras i samklang medskogsbruket, för att bevara värdefulla biotoper för kungsörnen. Skogsbruket ska vara hållbartoch framblickande för att bäst skydda arter som kungsörn. Kollisionsrisker med fågeldöd,beteendeförändring och habitatförlust, biotopförlust, barriäreffekter är exempel på olikafaktorer som påverkar artens fortlevnad på platser med vindkraftverk.Studier av kungsörnens rörelsemönster och utbredning har gjorts i Sverige. Örnarna märktesmed GPS-sändare i början av häckningssäsongen. Resultatet från dessa studier visade attkungsörnarna flög över långa sträckor efter häckning, det vill säga att de kan ha stora jakt- ochhäckningsområden. Vissa örnar flög längre än andra. Orsakerna var att häckningen misslyckadesoch att det kan ha varit ont om mat. Kunskaper om den hotade fågelartens beteendeoch häckning kan öka möjligheter till anpassningar vid vindkraftsanläggningar. Utformningenav vindkraft har skett i en balansgång mellan effektiv energiproduktion och miljöhänsyn. Fördet senare har olika mätmetoder påverkat utformningen av vindkraftverk, exempelvisklassning av höjdintervaller fåglarna flyger i. Kompromisser har gjorts för att lösa vissaintressekonflikter, det vill säga att man har klassificerat kungsörnspopulationer utifrån desslivskraft.Rekommendationer var vindkraft ska placeras är i kuperade områden med ungskog, då det ären biotop som kungsörnen undviker. Kungsörnens val av hemområden är väldigt individuella,vilket bör tas i beaktning vid etablering av skyddszoner intill en potentiell störningskälla som vindkraft.

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  • Fernandez-Chacon, Macarena
    et al.
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain.;Univ Loyola Andalucia, Fac Hlth Sci, Seville, Spain..
    Muhleder, Severin
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Regano, Alvaro
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Garcia-Ortega, Lourdes
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Rocha, Susana F.
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Torroja, Carlos
    Ctr Nacl Invest Cardiovasc CNIC, Bioinformat Unit, Madrid, Spain..
    Sanchez-Munoz, Maria S.
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Lytvyn, Mariya
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Casquero-Garcia, Veronica
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    De Andres-Laguillo, Macarena
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Muhl, Lars
    Karolinska Inst, Dept Med, Huddinge, Sweden..
    Orlich, Michael M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden..
    Gängel, Konstantin
    Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden..
    Camafeita, Emilio
    Ctr Nacl Invest Cardiovasc CNIC, Cardiovasc Prote Lab, Madrid, Spain.;CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain..
    Vazquez, Jesus
    Ctr Nacl Invest Cardiovasc CNIC, Cardiovasc Prote Lab, Madrid, Spain.;CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain..
    Benguria, Alberto
    Ctr Nacl Invest Cardiovasc CNIC, Genom Unit, Madrid, Spain..
    Iruela-Arispe, M. Luisa
    Northwestern Univ, Feinberg Sch Med, Dept Cell & Dev Biol, Chicago, IL USA..
    Dopazo, Ana
    CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain.;Ctr Nacl Invest Cardiovasc CNIC, Genom Unit, Madrid, Spain..
    Sanchez-Cabo, Fatima
    Ctr Nacl Invest Cardiovasc CNIC, Bioinformat Unit, Madrid, Spain.;CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain..
    Carter, Hannah
    Univ Calif San Diego, Dept Med, Div Med Genet, La Jolla, CA USA.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA..
    Benedito, Rui
    Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain..
    Incongruence between transcriptional and vascular pathophysiological cell states2023In: NATURE CARDIOVASCULAR RESEARCH, ISSN 2731-0590, Vol. 2, no 6, p. 530-549Article in journal (Refereed)
    Abstract [en]

    The Notch pathway is a major regulator of endothelial transcriptional specification. Targeting the Notch receptors or Delta-like ligand 4 (Dll4) dysregulates angiogenesis. Here, by analyzing single and compound genetic mutants for all Notch signaling members, we find significant differences in the way ligands and receptors regulate liver vascular homeostasis. Loss of Notch receptors caused endothelial hypermitogenic cell-cycle arrest and senescence. Conversely, Dll4 loss triggered a strong Myc-driven transcriptional switch inducing endothelial proliferation and the tip-cell state. Myc loss suppressed the induction of angiogenesis in the absence of Dll4, without preventing the vascular enlargement and organ pathology. Similarly, inhibition of other pro-angiogenic pathways, including MAPK/ERK and mTOR, had no effect on the vascular expansion induced by Dll4 loss; however, anti-VEGFA treatment prevented it without fully suppressing the transcriptional and metabolic programs. This study shows incongruence between single-cell transcriptional states, vascular phenotypes and related pathophysiology. Our findings also suggest that the vascular structure abnormalization, rather than neoplasms, causes the reported anti-Dll4 antibody toxicity. Fernandez-Chacon et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.

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  • Rodrigues, Mariana Teixeira
    et al.
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil..
    Michelli, Ana Paula Picaro
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil..
    Caso, Gustavo Felisola
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil..
    de Oliveira, Paloma Ramos
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil..
    Mendes Rodrigues Junior, Dorival
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Biomed Ctr, Dept Med Biochem & Microbiol, Sci Life Lab, S-75236 Uppsala, Sweden..
    Morale, Mirian Galliote
    Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil..
    Machado Junior, Joel
    Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil..
    Bortoluci, Karina Ramalho
    Univ Fed Sao Paulo UNIFESP, Pharmacol Dept, Escola Paulista Med, BR-04021001 Sao Paulo, Brazil..
    Tamura, Rodrigo Esaki
    Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.;Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Biol Chem Postgrad Program, BR-09920000 Diadema, Brazil..
    da Silva, Tamiris Reissa Cipriano
    Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil..
    Raminelli, Cristiano
    Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil..
    Chau, Eric
    Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA..
    Godin, Biana
    Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA.;Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY 10065 USA..
    Calil-Silveira, Jamile
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Nove de Julho, Hlth Board 3, BR-01525000 Sao Paulo, Brazil..
    Rubio, Ileana G. Sanchez
    Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil..
    Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer2023In: Pharmaceuticals, E-ISSN 1424-8247, Vol. 16, no 12, article id 1687Article in journal (Refereed)
    Abstract [en]

    Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise. Therefore, this study aimed to explore the antineoplastic effects of lysicamine in papillary TC (BCPAP) and ATC (HTH83 and KTC-2) cells. Lysicamine treatment reduced cell viability, motility, colony formation, and AKT activation while increasing the percentage of necrotic cells. The absence of caspase activity confirmed apoptosis-independent cell death. Necrostatin-1 (NEC-1)-mediated necrosome inhibition reduced lysicamine-induced necrosis in KTC-2, suggesting necroptosis induction via a reactive oxygen species (ROS)-independent mechanism. Additionally, in silico analysis predicted lysicamine target proteins, particularly those related to MAPK and TGF-beta signaling. Our study demonstrated lysicamine's potential as an antineoplastic compound in ATC cells with a proposed mechanism related to inhibiting AKT activation and inducing cell death.

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  • Mora, Gaia
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Genetic consequences of translocations in the Doñana population of the endangered Iberian lynx2024Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Conservation genetics for endangered species is crucial in long-term conservation actions.Inbreeding depression and genetic diversity are main genetic parameters with relevance toconservation. The Iberian lynx was by 2002 the most endangered felid in the world. Manyconservation programs have been carried out during the last 20 years, greatly improving theoutlook of the species. There is a paucity of information on the genetic consequences of thereintroduction program thus far. In the following research study, the most endangered Iberianlynx population, the Doñana population, is assessed to determine its actual genetic status andevaluate the genetic consequences of translocations initiated in 2007. This was achieved by thereconstruction of the pedigree of the wild population, and molecular analysis based on genotypedata with the use of Single Nucleotide Polymorphisms (SNPs). The molecular parameterscalculated were inbreeding coefficients, ancestry and genetic diversity. Results show an increase ingenetic diversity and a decrease in inbreeding following translocations. Post translocationinbreeding was found and explained by ancestral classes the individuals belonged to. These resultslay foundation for the importance of the ongoing translocations within the population andemphasize the need in the coming years for the conservation efforts carried out so far.

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    Popular science summary, Gaia Mora
  • Nüßgen, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity. CAD CAM Center Cologne, Institute of Automotive Engineering Cologne (IFK), Faculty of Automotive Systems and Production, Cologne University of Applied Science, Cologne, Germany.
    Degen, René
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity. CAD CAM Center Cologne, Institute of Automotive Engineering Cologne (IFK), Faculty of Automotive Systems and Production, Cologne University of Applied Science, Cologne, Germany.
    Irmer, Marcus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity. CAD CAM Center Cologne, Institute of Automotive Engineering Cologne (IFK), Faculty of Automotive Systems and Production, Cologne University of Applied Science, Cologne, Germany.
    Richter, Fabian
    Boström, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity.
    Ruschitzka, Margot
    Leveraging Robust Artificial Intelligence for Mechatronic Product Development: A Literature Review2024In: International Journal of Intelligence Science, ISSN 2163-0283, E-ISSN 2163-0356, Vol. 14, no 01, p. 1-21Article, review/survey (Refereed)
    Abstract [en]

    Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.

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  • Widmalm, Vera
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    Assessing the User Experienceof Hype Energy Drinks’ New Website: A study in UX development comparing the userexperience of two versions of the website Hype.com2023Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study explores the optimization of user experience (UX) and website goals through arelatively small-scale test with 10 participants. The research focuses on evaluating theimplementation of a new website prototype for Hype Energy Drinks, with an aim to improvehealth orientation and UX, specifically when communicating the product sections for isotonicdrinks and protein products. The study highlights the significance of meticulous website design,structure, and adherence to UX principles, such as usability, accessibility, consistency, and usercentered design.

    The findings demonstrate that the new website significantly enhances the user experience,particularly in conveying health-oriented product information. Improved structure and layoutcontribute to improved usability and effective communication of health-related products. However, both the old and new sites were perceived as having a sporty rather than a healthoriented look.

    The study also reveals the complexity of implementing animations and emphasizes theimportance of carefully considering the role and impact of animations in website design,particularly in facilitating clear and efficient communication of product information. Thefindings contribute to a better understanding of how website design and UX principles caneffectively communicate health-related products, while also highlighting areas for improvementand future research.

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  • Li, Xiaofei
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden..
    Andrusivova, Zaneta
    KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden..
    Czarnewski, Paulo
    KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Stockholm, Sweden..
    Langseth, Christoffer Mattsson
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
    Andersson, Alma
    KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Genentech Inc, Dept Artificial Intelligence & Machine Learning, Res & Early Dev, South San Francisco, CA USA..
    Liu, Yang
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China..
    Gyllborg, Daniel
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
    Braun, Emelie
    Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden..
    Larsson, Ludvig
    KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden..
    Hu, Lijuan
    Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden..
    Alekseenko, Zhanna
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden..
    Lee, Hower
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
    Avenel, Christophe
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division Vi3. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Dept Informat Technol, Uppsala, Sweden.;SciLifeLab, BioImage Informat Facil, Sci Life Lab, Stockholm, Sweden..
    Kallner, Helena Kopp
    Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Obstet & Gynecol, Danderyd, Sweden..
    Akesson, Elisabet
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Stockholms Sjukhem, R&D Unit, Stockholm, Sweden..
    Adameyko, Igor
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Med Univ Vienna, Ctr Brain Res, Dept Neuroimmunol, Vienna, Austria..
    Nilsson, Mats
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
    Linnarsson, Sten
    Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden..
    Lundeberg, Joakim
    KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden..
    Sundstrom, Erik
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden..
    Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin2023In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 26, no 5Article in journal (Refereed)
    Abstract [en]

    The authors created a comprehensive developmental cell atlas for spatiotemporal gene expression of the human spinal cord, revealed species-specific regulation during development and used the atlas to infer novel markers for pediatric ependymomas. The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5-12. This revealed how the cell fate commitment of neural progenitor cells and their spatial positioning are spatiotemporally regulated by specific gene sets. We identified unique events in human spinal cord development relative to rodents, including earlier quiescence of active neural stem cells, differential regulation of cell differentiation and distinct spatiotemporal genetic regulation of cell fate choices. In addition, by integrating our atlas with pediatric ependymomas data, we identified specific molecular signatures and lineage-specific genes of cancer stem cells during progression. Thus, we delineate spatiotemporal genetic regulation of human spinal cord development and leverage these data to gain disease insight.

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  • Nedstrand, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering, Industrial Engineering and Management.
    The potential of a bidding zone reconfiguration to foster an expansion of renewable energy production capacity in Sweden2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Effective electricity market design plays an important role in facilitating the transition to a sustainable energy system, and a well-structured electricity market has proven to be crucial in the expansion of renewable energy production capacity. One way of designing the electricity market is by implementing bidding zones, which Sweden did in 2011. The structure of the Swedish bidding zones is however currently being reviewed by the Swedish TSO, and alternative bidding zone configurations are being evaluated based on how they potentially could impact the future energy market. One of the aspects that is evaluated is how the bidding zone reconfiguration could effect the energy transition in Sweden. This thesis aims to investigate and assess how an alternative bidding zone configuration could perhaps foster an expansion of renewable energy production capacity in Sweden, by simulating the dispatch and build out of renewable production capacity in Sweden for the years between 2024 to year 2040.

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  • Löthberg, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelse av vårdpersonalens bemötande på akutmottagning2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: In Sweden, approximately 1.6 million people aged 19 or older visit emergency departments annually. A large proportion of complaints in health care are based on experience of treatment, where poor treatment is associated with poorer patient safety, more resource-intensive care and more ill patients. Good treatment, on the other hand, improves care outcomes and reduces staff burnout.

    Aim: The aim of this study was to investigate patients' experiences of the care staff's treatment in the emergency department.

    Method: The study is a literature review with a qualitative approach and has a descriptive design. Twelve original qualitative articles were retrieved from PubMed and CINAHL. These were quality reviewed for bias with a template, then analyzed with qualitative content analysis.

    Results: Four categories emerged from the content analysis. Compassion, being met as a human being despite the medical context. Respect, was a vital aspect in the experience of treatment. Information, was a central part of both the experience of treatment and of their situation. Stress, staff stress had a significant effect on patients and their experience. 

    Conclusion: Patients expressed some common needs such as to be treated as human beings with empathy and compassion, to be respected and not judged by staff, to receive understandable and frequent information, and that staff stress does not negatively impact treatment. They described specific positive effects when needs were met and specific negative effects when needs were not met. In summary, patients were greatly affected psychologically and emotionally based on their experiences of these key aspects of the treatment they received in the emergency department.

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  • Jonsson, Kristoffer
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Fjällström, Malte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Universitetet och AI: En studie kring anställda på universitet och högskolors acceptans av AI2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • Jonsson, Petra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Human Geography.
    Flaggskeppsbyggnader som instrument i platsmarknadsföring: En fallstudie på Sara kulturhus i Skellefteå2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Flaggskeppsbyggnader är både en del av städers marknadsstrategier och en plats där stadens varumärke manifesteras i de praktiker byggnaden bjuder in till. Denna uppsats undersöker hur flaggskeppsbyggnader används som ett instrument i platsmarknadsföring genom en fallstudie på Sara kulturhus i Skellefteå. Utifrån en kvalitativ ansats har semistrukturerade intervjuer utförts med aktörer med relation till kulturhuset och Skellefteås platsmarknadsföring. Sara kulturhus är byggt i lokalproducerat trä, vilket givit en lokal förankring där materialvalet, tillsammans med byggnadens höjd, gett staden en atmosfär av modernitet vilket uppmärksammats i internationell media. Således har byggnaden blivit ett flaggskepp även i människors medvetande vilket ökat stadens attraktivitet. Kulturhuset öppnades för allmänheten 2021 och nyhetens behag börjar nu avta. Kulturhuset kommer därför möta utmaningar för att behålla sin roll som Skellefteås ansikte utåt. Studiens deltagare vill uppnå detta genom att kontinuerligt lyfta designen i trä och ambitionerna om hållbarhet. Ett av kulturhusets mål är att det ska vara ett hus för alla, men i en stad som Skellefteå med en diversifierad befolkning finns det hinder för att nå ett sådant mål. 

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  • Gerdelius, Patrik
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Partial Differential Equations.
    Hugo, Sjönneby
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Partial Differential Equations.
    Detecting Fraudulent User Behaviour: A Study of User Behaviour and Machine Learning in Fraud Detection2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study aims to create a Machine Learning model and investigate its performance of detecting fraudulent user behaviour on an e-commerce platform. The user data was analysed to identify and extract critical features distinguishing regular users from fraudulent users. Two different types of user data were used; Event Data and Screen Data, spanning over four weeks. A Principal Component Analysis (PCA) was applied to the Screen Data to reduce its dimensionality. Feature Engineering was conducted on both Event Data and Screen Data. A Random Forest model, a supervised ensemble method, was used for classification. The data was imbalanced due to a significant difference in number of frauds compared to regular users. Therefore, two different balancing methods were used: Oversampling (SMOTE) and changing the Probability Threshold (PT) for the classification model. 

    The best result was achieved with the resampled data where the threshold was set to 0,4. The result of this model was a prediction of 80,88% of actual frauds being predicted as such, while 0,73% of the regular users were falsely predicted as frauds. While this result was promising, questions are raised regarding the validity since there is a possibility that the model was over-fitted on the data set. An indication of this was that the result was significantly less accurate without resampling. However, the overall conclusion from the result was that this study shows an indication that it is possible to distinguish frauds from regular users, with or without resampling. For future research, it would be interesting to see data over a more extended period of time and train the model on real-time data to counter changes in fraudulent behaviour.

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    Detecting_Fraudulent_User_Behaviour
  • Ferlander, Ludvig
    et al.
    Gustavsson, Linus
    Artificell intelligens inom cybersäkerhet: En studie av den svenska banksektorn2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In an increasingly digitalized society, the cyber threats faced by banks have become more extensive and complex. At the same time, artificial intelligence has developed into a powerful and disruptive technology that can be used to strengthen cybersecurity and counter financial crime, among other things. The purpose of the study was to map how Swedish banks use AI to counteract cyber threats and financial crime, and what benefits and challenges this entails. The study is based on four qualitative interviews with bank officials specialized in cybersecurity or financial crime. The Technology-Organization-Environment framework is used to analyze the challenges and factors affecting the use of AI. The results show that AI models are used for several security purposes, such as preventing DDoS attacks, malware detection and identifying signs of financial crime. The main benefits of AI are the ability to analyze large amounts of data in real time and to identify patterns and anomalies that are difficult for the human eye to see. However, there are a number of challenges for Swedish banks in the adoption and use of AI related to regulation, ethics and competence.

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    Artificiell intelligens inom cybersäkerhet
  • Werner, Ann
    et al.
    Södertörn University.
    Novelskaitė, Aurelija
    Lukovitskaya, Elena
    Feminist Methodologies for Gender Studies Teaching: Cross-Case Analysis of Practical Applications in Three Universities2023In: Information & Media, E-ISSN 2783-6207, Vol. 98, p. 53-69Article in journal (Refereed)
    Abstract [en]

    In this article interpersonal communication in Gender Studies teaching is mapped and compared in feminist pedagogy in three universities: Södertörn University in Sweden, Novgorod State University in Russia and Vilnius University in Lithuania. The aim of this article is, first, to compare the uses of feminist methodologies in teaching during the first semester undergraduate Gender Studies courses in a cross-case comparison. And secondly, to suggest developments needed to pursue teaching in Gender Studies in the three countries. Scholarly discussions about feminist pedagogies are accounted for and characteristics from the field are identified and compared in the three empirical cases. The article further draws on qualitative feminist methodology and concludes that while the contexts investigated are different, the methodologies used have similarities. In all three universities the teaching methods focus on students’ experiences and differences, teacher’s reflexivity, working in smaller groups, highlighting community building and empowerment. In the conclusion these teaching holdings are discussed, and further development of interpersonal communication in Gender Studies teaching is suggested.

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  • Forsberg, Ida
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Gyllhag, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Rörelsepauser i matematikundervisningen: En enkätstudie om lärares användning av rörelsepauser2023Independent thesis Advanced level (professional degree), 240 HE creditsStudent thesis
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  • Ahlqvist, Gustaf
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Tesfai, Nftalem
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    AI och hälsovård: en studie om Acceptansen för AI inom hälsovården2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Mental health issues have become increasingly common and are now identified as a global problem. Figures for young Swedes aged 16-29 suffering from mental health problems show alarming increases over the past 15 years. Concurrently with the rise in mental health issues, studies highlighting the importance of AI in the healthcare sector are being conducted. These studies cover both advantages and limitations, with a recurring theme being a lack of acceptance from users. The purpose of this study is to examine the acceptance among young adults, both men and women, in Sweden, within the age range of 16-29 years. Acceptance is investigated through a quantitative survey based on the Technology Acceptance Model (TAM). The survey included a total of 73 respondents. However, we would like to point out that this number may limit the validity and generalizability of the findings.

    For both chatbots and avatars, five hypotheses have been defined, with all related to chatbots being accepted while four out of five related to avatars are accepted. The results of the study's hypotheses show clear relationships, with positive correlations and significant values at the one percent level (p < 0.01). There are clear connections between perceived ease of use and perceived usefulness, perceived usefulness and attitude toward use, as well as between attitude toward use and intended use. These results, based on collected data from the survey, reveal an overall low acceptance among young Swedes regarding AI-integrated health advice and indicate a certain level of concern and hesitation regarding the use of AI in mental healthcare

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  • Tajani, Martina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Barn med autismspektrumtillstånd, föräldrars erfarenheter och upplevelser2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Introduction: Autism Spectrum Disorder (ASD) is a complex neurological impairment that begins early in life, during infancy or childhood. The greatest challenges for individuals with ASD lie within the areas of social interaction and communication with other people, as well as repetitive behavior patterns. 

    Aim: To explore parent’s experiences and perceptions of being a parent to a child with autism spectrum disorder (ASD).

    Method: A descriptive literature review with a qualitative approach was conducted according to Friberg (2017). The literature review was based on ten original scientific articles. Antonovsky’s theory, sense of coherence, SOC was used as the theoretical framework.

    Results: The results are presented in three categories: Lack of knowledge and understanding, which describes parent’s experiences of the diagnostic process. Health and the impact of autism on the family, which describes parent’s health and experiences in everyday life. Well-being, which describes parent’s ways of being able to recover and get respite. 

    Conclusion: This study demonstrated that parent’s of children with ASD experience significant stress and workload, both mentally and physically, which is often invisible to society. The study reveals that within healthcare, it is often challenging to get an early diagnosis due to a lack of knowledge and understanding among healthcare professionals. Once the diagnosis is established, it can be difficult for some parent’s to handle the situation. The parent’s in this study experienced challenges in various environments, including the home, public places, health care, and school. The study highlights society’s lack of understanding of ASD and stereotypical views on children’s behavior which contribute to parent’s feeling judged, misunderstood, and isolated. Despite this, most parent’s demonstrate a resilience for adversity, an enhanced personal growth, a more realistic perspective on life, and a joy for their children’s achievements in life.

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  • Viktorsson, Charlotte
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Portugal, Ana Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Division of Neuropsychiatry, Department of Women’s and Children’s Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
    Falck-Ytter, Terje
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Division of Neuropsychiatry, Department of Women’s and Children’s Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
    Genetic and environmental contributions to gaze lateralization across social and non-social stimuli in human infants2024In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, no 1, article id 3668Article in journal (Refereed)
    Abstract [en]

    A tendency to look at the left side of faces from the observer’s point of view has been found in older children and adults, but it is not known when this face-specific left gaze bias develops and what factors may influence individual differences in gaze lateralization. Therefore, the aims of this study were to estimate gaze lateralization during face observation and to more broadly estimate lateralization tendencies across a wider set of social and non-social stimuli, in early infancy. In addition, we aimed to estimate the influence of genetic and environmental factors on lateralization of gaze. We studied gaze lateralization in 592 5-month-old twins (282 females, 330 monozygotic twins) by recording their gaze while viewing faces and two other types of stimuli that consisted of either collections of dots (non-social stimuli) or faces interspersed with objects (mixed stimuli). A right gaze bias was found when viewing faces, and this measure was moderately heritable (A = 0.38, 95% CI 0.24; 0.50). A left gaze bias was observed in the non-social condition, while a right gaze bias was found in the mixed condition, suggesting that there is no general left gaze bias at this age. Genetic influence on individual differences in gaze lateralization was only found for the tendency to look at the right versus left side of faces, suggesting genetic specificity of lateralized gaze when viewing faces.

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  • Sparrman, Anna
    et al.
    Department of Thematic Studies: Child Studies, Linköping University, Linköping, Sweden.
    Sjöberg, Johanna
    Department of Thematic Studies: Child Studies, Linköping University, Linköping, Sweden.
    Hrechaniuk, Yelyzaveta
    Department of Thematic Studies: Child Studies, Linköping University, Linköping, Sweden.
    Köpsell, Linn
    Swedish Archive of Children’s Art, Eskilstuna, Sweden.
    Isaksson, Karin
    Swedish Archive of Children’s Art, Eskilstuna, Sweden.
    Eriksson, Maria
    Swedish Archive of Children’s Art, Eskilstuna, Sweden.
    Orrmalm, Alex
    Department of Thematic Studies: Child Studies, Linköping University, Linköping, Sweden.
    Venäläinen, Päivi
    The Art Centre for Children and Young People’s Archive, Hyvinkää, Finland.
    Ågren, Ylva
    Department of Education, Communication and Learning, University of Gothenburg, Gothenburg, Sweden.
    Coulter, Natalie
    Department of Communication &amp; Media Studies, York University, Toronto, Canada.
    Kjellman, Ulrika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Aarsand, Pål
    Department of Education and Lifelong Learning, NTNU, Trondheim, Norway.
    Tesar, Marek
    School of Learning, Development and Professional Practice, University of Auckland, Auckland, New Zealand.
    Sanchez-Eppler, Karen
    American Studies and English, Amherst College, Amherst, MA, USA.
    Wells, Elizabeth
    Archivist and Records Manager, Westminster School, London, UK.
    Archives and children's cultural heritage2023In: Archives and records, ISSN 2325-7962, E-ISSN 2325-7989Article in journal (Refereed)
    Abstract [en]

    In this explorative and collectively written paper, researchers and archivists from the research project Children’s cultural heritage — the visual voices of the archive ponder, wrestle with, confront, and dig deeper into what it means to preserve and include children’s own voices in archives. The authors acknowledge that child-produced cultural objects are historical landmarks and significant parts of national heritage. The article raises questions about where and how the ‘doing’ of what is here called children’s cultural heritage takes place, what it means to archive from children’s perspectives, and what aspects of children are saved during these preservation and archival management processes. To collect, preserve and provide access to heritage might empower and affirm individuals and subordinated groups of people who have not been seen or heard in the historical past, in the present, or in future pasts. Children, as a category, is one such subordinated group in heritage contexts. Adults therefore have a responsibility to empower children by strengthening their position towards other social groups, towards society and the heritage domain. This article provides insights into the challenges that heritage establishments face in taking children’s cultural heritage seriously.

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  • Jönsson, Johanna
    Sveriges lantbruksuniversitet, Institutionen för mark och miljö; Jordbrukets vattenhushållning och vattenkvalitet.
    Modellering av extern fosforbelastning till Vombsjön: En studie med hydrologiska modellen Soil and Water Assessment Tool, SWAT+2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Vombsjön is one of the most important drinking water sources in southern Skåne, supplying drinking water to Malmö and parts of Lund. The lake suffers from eutrophication and reoccurring algal blooms which are complicating the drinking water production. Phosphorus leaching from the bottom sediment of the lake (internal load) and phosphorus coming from the agriculture- dominated catchment (external load) needs to be investigated to address the eutrophication issues and ensure a safe drinking water production.

    As part of this thesis, the external phosphorus load has been investigated through hydrological modeling of the catchment area, using Soil and Water Assessment Tool (SWAT+). The modeling results show that the approximately 45 000 hektar big catchment area contributes to an average of 25 tons of total phosphorus per year via the three main watercourses that flows into Vombsjön. The average load is based on simulations between 2011 and 2022, and the load varies between 14–37 tons of total phosphorus for the examined years. 79 % of the total phosphorus load is supplied to the lake via the largest watercourse, Björkaån, 11 % via Torpsbäcken and 10 % via Borstbäcken.

    The monthly water flow has been manually calibrated and validated against flow measurements at one point in the catchment area. Environmental monitoring data from an agriculture- dominated catchment area, located in the same leakage region as most of the Vombsjöns catchment area, was used to compare the magnitude of the area-specific phosphorus transport. The area-specific monthly and annual transports of total phosphorus were within the same order of magnitude, but there were significant variations between some years and months.

    The hydrological model needs further development to better simulate water flow during autumn and winter, when the flow is generally highest. Furthermore, the model needs to be calibrated and validated against more flow stations and measured phosphorus concentrations within the catchment area to determine how well the model simulates phosphorus transport.

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  • Gesto Herrera, Brais
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Lithium abundances through distinct stellar populations in Omega Centauri2023Independent thesis Basic level (degree of Bachelor), 5 HE creditsStudent thesis
    Abstract [en]

    The renowned Omega Centauri (NGC 5139) is one of the most massive and complex known globular clusters in terms of multiple populations. In this project, we aim to investigate the chemical abundance of lithium in RBG stars in this cluster in pursuit of unraveling the that govern the formation of these distinct populations. By analyzing spectroscopic and photometric data, we determine the necessary stellar parameters and produce an algorithm that yields the Li abundance for each star, as well as its errors and an upper limit for the content of this element. This is followed by a comparison with the results obtained in Mucciarelli et al.(2018). Finally, we investigate how Li behaves within the different stellar populations of Omega Centauri using data from Milone et al. (2017a).

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  • Hodzic, Mersad
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    "13 meter från marken": Poetiska texter i en svensk niondeklass2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This master’s thesis investigates poetic text writing through a teaching project conducted on a secondary school class in Sweden. Inspired by ekphrastic poetry, the teaching project consisted of poetry and literature reading. The students visited a sculpture related to the literature, upon which they wrote poetic texts about the sculpture. The main purpose of the study is to describe how teaching in the Swedish subject can make use of Swedish language teaching by developing students’ poetic texts that touches on topics such as living conditions and identity. Drawing from thematic narrative analysis, most notably Bamberg’s positioning model, the analysis investigates the narratives constructed in the students’ poetic texts as well as identity aspects negotiated through the narratives. The students’ identities were further discovered through participant observation and semi-structured interviews to deepen the understanding of the meeting between art, identity and learning.The general perception drawn from the interviewees’ answers is that the Swedish subject rarely includes knowledge of nor writing of poetic texts. However, the study emphasises that poetry could have an integral part of the education in the Swedish subject in secondary education.The results show that the students’ poetic texts tend to relate to the sculpture and the physical environment, as well as the social context of the environment. Furthermore, the identities of the students were shown to have a high relevance in the writing process. The teaching project was based on principles of culturally sustaining pedagogy and aimed at contributing to the sociocultural support of the school. As the students’ language and cultural backgrounds proved to be significant in the writing process, it became evident that multilingualism was a natural part of the student’s everyday school life.

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  • Wistrom, Livia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Lilja, Judith
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Rysslands invasion av Ukraina: En analys av svenska multinationella företags hantering av en exogen kris2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sedan Ryssland invaderade Ukraina har flera multinationella företag valt att pausa eller avveckla sin verksamhet i Ryssland. I uppsatsen undersöks hur svenska multinationella företags val av åtgärder och hur de har kommunicerats av företagen själva och svensk nyhetsmedia påverkar konsumenternas syn på företagens legitimitet. Det möjliggörs genom att analysera företagens sätt att kommunicera enligt olika kommunikationsstrategier, hur ofta företagen nämns i nyhetsmedia kopplat till ämnet och hur de framställs i rapporteringen. Vidare används en enkätundersökning för att involvera konsumentperspektivet för att se hur företagens legitimitet påverkas. Resultatet av enkätundersökningen visar att konsumenter föredrar en ackommodativ kommunikationsstrategi, vilket innebär att företagen genomför åtgärder och kommunicerar på ett sätt som visar på ansvarstagande och empati för den eller de drabbade av en kris. Hur ofta de specifika företagen vi studerar förekommer i nyhetsmedia, och hur de porträtteras kopplat till Rysslands invasion av Ukraina visar inte på något tydligt samband med hur legitimiteten påverkas. 

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  • Loberg Nelisse, Miranda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Östergren, Madeleine
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Den stressiga arbetsmiljön: Chefers stressförebyggande arbetsmiljöarbete2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study is to find out how managers with employee responsibility work with work environmental questions to prevent and manage stress in the workplace. The study uses  a qualitative method with semi-structured interviews. In total 7 interviews were carried out with 7 different managers who all had employee responsibility. All interviews were recorded. The material was then processed and researched which then culminated in a detailed results and analysis section off the study. In order to further decipher and interpret the material, it was analyzed using the demands and control model in combination with the social support model coined by Karasek & Theorell (1990) and Johnson & Hall (1988). The result shows that managers with responsibility over employees work actively with work environmental questions and more specifically to prevent stress in the workplace. According to the managers themselves, open communication between the manager themselves and the employees was emphasized as the most important tool for preventing and managing stress in the workplace. This is reflected in the study's results. The results showed, first of all, that communication in combination with supporting one's employees is essential for preventing stress in the workplace. The communication mainly focused on the employees' work situation and well-being, but also that, as a manager, constantly being responsive and listening to your employees. Furthermore, the results showed that managers work to prevent stress with the help of digital tools, in addition to this, employee interviews and employee surveys is also frequently taking place. Managers with  responsibility over employees were also stated to have action plans for if an employee were to suffer from stress which then results in mental illness. The action plan often includes rehabilitation, job training but also the possibility of psychological and occupational therapist help. The study hopes to be a contribution to understanding the current trend where mental illness and sick leave due to work are increasing in Sweden.

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  • Holst, Sofia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Bossen, Ebba
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Immateriella tillgångar och konkursprediktion: Undersökning av en justerad Skogsviks Modell för svenska SMEs2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie syftar till att anpassa Skogsviks konkursprediktionsmodell från 1987 för svenska små och medelstora företag (SMEs). Studien fokuserar även på hur nya redovisningsstandarder för immateriella tillgångar påverkar modellen. Genom att inkludera ett nyckeltal som speglar förhållandet mellan immateriella tillgångar och totala tillgångar (IA) i den justerade modellen, möjliggör studien en jämförelse med Skogsviks Modell. Detta för att utvärdera nyckeltalets relevans i förutsägelsen av konkursrisk för SMEs och undersöka den justerade modellens prediktionsförmåga. Studien undersöker även vilka av Skogsviks Modells variabler som är effektiva för att förutspå konkurs för SMEs. Denna studie bidrar till forskning om redovisningsbaserade konkursprediktionsmodeller för SMEs inom ramen för svensk redovisningspraxis. Modellen skapas genom en probit regression och utvärderas sedan genom två valideringstester, Receiver Operating Characteristic (ROC) och Cumulative Accuracy Profile (CAP). Analysen omfattar data från 544 svenska företag, varav 81 har gått i konkurs. Resultaten visar att den justerade modellen, med nyckeltalet IA, har en högre prediktionsförmåga för SMEs jämfört med Skogsviks Modell utifrån dagens redovisningsstandarder för immateriella tillgångar. Studien bekräftar även att nyckeltalen ROA (Avkastning på totala tillgångar), ETA (Eget kapitalandel) och IA (Immateriella tillgångar i relation till totala tillgångar) är effektiva indikatorer för att förutspå konkursrisken för svenska SMEs idag. 

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  • Aspö, Annie
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Uppsala University.
    An investigation of o-phthaldialdehyde as a derivatization reagent and optimization of instrumental parameters for qualitative amino acid profiling via UPLC-UV2023Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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