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  • Lennhammer, Emma
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Rights out of Reach?: Justifications of Intellectual Property Rights in Relation to the Fulfilment of Socioeconomic Human Rights2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis, three perspectives on the justification of intellectual property rights are investigated in the light of conflicting socioeconomic human rights. This is done by using a comparative method, where the perspectives chosen are reviewed through the lense of rights as legitimate claims, as well as accessibility of rights. The purpose is to review as to how the ownership of ideas and inventions can be justified in relation to the socioeconomic challenges faced in many parts of the world. The principal research question is: How can intellectual property rights be justified and how can it be evaluated against the backdrop of socioeconomic rights and moral obligations? To answer this question, I posed three sub-questions: First, how are intellectual property rights justified in the existing research chosen as an entry point for this thesis? Drawn from this, how can the justification of intellectual property rights be understood as a moral concern in a socioeconomically unequal world? Taking a cue from this, what questions need to be answered to better understand the transnational moral obligations linked to intellectual property rights? By reviewing the perspectives presented on the justification of intellectual property rights, I make three concluding statements ​— intellectual property rights cannot be justified in cases where they affect other individuals’ socioeconomic rights negatively; excessive benefits gained for creators is not morally reasonable; and the unequal distribution of power and opportunities in relation to transnational moral responsibilities need to be recognised.

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  • Mæhle Førland, Jostein
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Hvordan ville Jesus anmeldt dette spillet?: – en studie av kristne videospillsnettsider gjennom perspektivet medialisering av religion.2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study aims to show how the religious worldview of the christian gaming site Geeks under Grace shapes their view on videogames and gaming culture. The goal is to understand the material through Hjarvards theories of mediatization of religion (2011), more specifically the aspects ”Media as language” and ”Media as Enviroment”. The following research questions are formulated to conduit this research: ”How do the authors and editors behind the website Geeks under Grace use religion and religious terms in understanding video games?” and ”How can the website Geeks under Grace be understood based on the dynamics ”Media as language” and ”media as environment”, according to the perspective mediatization of religion”. Through textual analysis of video game reviews and essays about christianity and gaming the study shows an individualistic form for christianity present in the material. Furthermore, it shows how the website makes frames and environments where they combine elements from both the world of gaming and the world of christianity to try to make a sense of belonging, and at the same time try to teach religious values through the use of videogames.

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  • Jehrlander, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Vem har rätt till äktenskap? Frågan som splittrar Europa2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Should same sex couples have a right to marriage? This question has been debated frequently during the last two decades. The legislation across Europe shows a divide between countries that have legalised same-sex marriage and countries that have introduced constitutional bans on same-sex marriage. Using a theory that emphasises the moral dimension of human rights, I examine the right to marriage in the European Convention of Human Rights from an ethical perspective. The purpose of this thesis is threefold. The first aim is to investigate how the right to marriage is regulated in The European Convention on Human Rights and how its interpreted by The European Court of Human Rights. The second aim is to identify and assess central arguments in the debate about same sex marriage from a human rights perspective. The third and final aim is to perform a critical examination of the right to marriage in the European Convention of Human rights from an ethical perspective.

     

    This study shows that The European Court of Human Rights is cautious in its interpretation of the right to marriage and has chosen to await a European consensus before including same-sex couples in the right to marriage. By looking closer at the evolutionary interpretation of the convention, as discussed by George Letsas & Kanstantsin Dzehtsiarou, I conclude that this interpretation should be based on certain moral principles. Through the examination of central arguments in the same-sex marriage debate I draw the conclusion that same sex couples have a moral right to marriage. Thus, this thesis suggests that there is a contradiction between the moral dimension of human rights and The European Court of Human Rights interpretation of the right to marriage for same-sex couples. I therefore argue that there should be an ethical demand to include same sex-couples in the right to marriage.

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  • Jorild, Elina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Staf, Kristin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Perinatala utfall hos kvinnor som genomgått könsstympning2020Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    ABSTRACT

    Background Female Genital Mutilation (FGM) is an ancient tradition with strong ties to cultural and ethnic identity. More than 200 million women and girls are estimated to be exposed, and about 3.9 million more girls are at risk each year. The proportion of women from countries where female genital mutilation is common, and which gives birth to children in Sweden has increased with an increased immigration. Female genital mutilation is internationally considered as a violation of human rights and a violation of women's and children's rights.

    Aim To compare the incidence and risk of perinatal complications among women with a diagnosis of FGM with women without this diagnosis who has given birth to a child in Sweden during the years 2007 - 2017.

    Method A population-based cohort study.

    Results The main result of this study is that children born of women with an FGM-diagnosis have a significantly increased risk of low apgar scores, being born Small for Gestational Age, convulsions, perinatal death and prolonged pregnancy could be observed.

    Conclusion FGM is associated with a number of serious perinatal complications. The greatest risk was seen between female genital mutilation and being born Small for Gestational Age, prolonged pregnancy and intrauterine fetal death. These relationships were robust regardless of which country the woman was born. It can be concluded that women with an FGM diagnosis and their newborn children belong to a risk group. It is very important to work preventively to protect these women and children's health.

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  • Marques, Catarina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Granström, Emma
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    MacDowall, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Moreira, Nuno Canto
    Karolinska Univ, Dept Clin Neurosci, Pediat Radiol Sect, Sjukhuset Solna, K8, Stockholm, Sweden..
    Skeppholm, Martin
    Karolinska Inst, Hlth Econ & Hlth Evaluat Res Grp, Dept Learning Informat Management & Eth, Med Management Ctr, Stockholm, Sweden..
    Olerud, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Accuracy and Reliability of X-ray Measurements in the Cervical Spine2020In: Asian Spine Journal, ISSN 1976-1902, E-ISSN 1976-7846, Vol. 14, no 2, p. 169-176Article in journal (Refereed)
    Abstract [en]

    Study Design: This study is a post hoc analysis of a multicenter prospective randomized controlled trial which compared artificial disc replacement and anterior cervical discectomy and fusion. Purpose: Useful radiographic parameters for assessing cervical alignment include the Cobb angles, T1 slope (TS), occipitocervical inclination (OCI). K-line tilt (KLT), and cervical sagittal vertical axis (cSVA). This study aimed to determine measurement accuracy and reliability for these parameters. Overview of Literature: Various authors have assessed repeatability by comparing different methods of measurement, but knowledge of measurement error and minimal detectable change is scarce. Methods: We evaluated 75B lateral cervical radiographs. One medical student and one spine surgeon (i.e., measured x2 within 4 weeks) independently measured the parameters obtaining 5,850 values. Standard error of measurement (SEm) and minimum detectable change (MDC) were calculated for each parameter. The accuracy and reliability of the Cobb angle measurements were calculated for the different types of angles: cervical lordosis, prosthesis angle, segmental angle with two hone surfaces (SABB), and segmental angle with one bone and one metal surface. Reliability was determined with intraclass correlation coefficient (ICC). Results: SEm was 1.8 degrees and MDC was 5.0 degrees for the Cobb angle, with an intraobserver/interobserver ICC of 0.958/0.8B6. All the different subtypes of Cobb angles had an ICC higher than 0.950, except SABB (intraobserver/interobserver ICC of 0.922/0.716). The most accurate and reliable measurement was for KLT. Conclusions: This study provides normative data on SEm and MDC for Cobb angles, T1S, KLT, OCI, and cSVA in cervicalcervicai lateral radiographs. Reliability was excellent for all parameters except SABB (e.g., good).

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  • Söderberg, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Route Planning for Heavy Vehicles on Real World Maps2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Fast route planning for a standard car is well explored, lots of research, and many algorithms exist. For trucks or other heavy vehicles, the available research and quick algorithm alternatives dwindle. This thesis focuses on available alternatives for trucks and other vehicles with attributes hindering them from traversing parts of the road network. Attributes like height are one among many, which can hinder a vehicle on its path. These attributes can vary greatly and is the reason why known solutions can’t be applied. Many well-known solutions rely partially on precalculated data regarding the shortest path for its performance. Precalculating for all possible combinations of attributes is not practical due to the number of possible configurations and the amount of computing needed for each one.

    The implemented solution is derived from multiple existing solutions and was evaluated on a graph representing Sweden’s road network. The solution is sufficiently fast to allow commercial use and allows changes to the road network with nightly updates. The solution is based on trying to predict which roads are more important when searching for the shortest path. With this knowledge, a search for the shortest path can be said to prioritize the before mentioned roads, which results in it finding its goal faster.

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  • Lindgren, Sebastian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Creating and Improving Machine Learning Algorithms for Plant Disease Identification2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In forestry and agricultural crop growing there has always been a need to identify plant diseases. The purpose of this is to faster remove a harmful plant within a larger group to reduce its effect on the crop yield. Currently, the major way to identify plant diseases is through manual labor where an plant pathology expert identifies diseases by looking at the plant. The aim of this project is to explore how image analysis can be utilised for faster identification of plant diseases. The report will also present descriptions of different relevant plant diseases, the relevant data sets that have been used, and the validity of the results.

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  • Albinsson, Bo
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Lab Clin Microbiol, Uppsala, Sweden..
    Jääskeläine, Anu E.
    Univ Helsinki, Dept Virol, Helsinki, Finland.;Helsinki Univ Hosp Lab Serv HUSLAB, Dept Virol & Immunol, Helsinki, Finland..
    Värv, Kairi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Natl Inst Hlth Dev, Dept Virol & Immunol, Tallinn, Estonia..
    Jelovse, Mateja
    Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia..
    GeurtsvanKessel, Corine
    Erasmus MC, WHO Collaborating Ctr Arbovirus & Viral Haemorrha, Dept Virol, Rotterdam, Netherlands..
    Ven, Sirkka
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Järhult, Josef D.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Reuske, Chantal
    Erasmus MC, WHO Collaborating Ctr Arbovirus & Viral Haemorrha, Dept Virol, Rotterdam, Netherlands.;Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, Bilthoven, Netherlands..
    Golovljova, Irina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Natl Inst Hlth Dev, Dept Virol & Immunol, Tallinn, Estonia..
    Avsic-Zupan, Tatjana
    Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia..
    Vapalaht, Olli
    Univ Helsinki, Dept Virol, Helsinki, Finland.;Helsinki Univ Hosp Lab Serv HUSLAB, Dept Virol & Immunol, Helsinki, Finland.;Univ Helsinki, Dept Vet Biosci, Helsinki, Finland..
    Lundkvist, Åke
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Multi laboratory evaluation of ReaScan TBE IgM rapid test, 2016 to 20172020In: Eurosurveillance, ISSN 1025-496X, E-ISSN 1560-7917, Vol. 25, no 12, p. 27-36, article id 1900427Article in journal (Refereed)
    Abstract [en]

    Tick-borne encephalitis (TBE) is a potentially severe neurological disease caused by TBE virus (TBEV). In Europe and Asia, TBEV infection has become a growing public health concern and requires fast and specific detection. Aim: In this observational study, we evaluated a rapid TBE IgM test, ReaScan TBE, for usage in a clinical laboratory setting. Methods: Patient sera found negative or positive for TBEV by serological and/or molecular methods in diagnostic laboratories of five European countries endemic for TBEV (Estonia, Finland, Slovenia, the Netherlands and Sweden) were used to assess the sensitivity and specificity of the test. The patients' diagnoses were based on other commercial or quality assured in-house assays, i.e. each laboratory's conventional routine methods. For specificity analysis, serum samples from patients with infections known to cause problems in serology were employed. These samples tested positive for e.g. Epstein-Barr virus, cytomegalovirus and Anaplasma phagocytophilum, or for flaviviruses other than TBEV, i.e. dengue, Japanese encephalitis, West Nile and Zika viruses. Samples from individuals vaccinated against flaviviruses other than TBEV were also included. Altogether, 172 serum samples from patients with acute TBE and 306 TBE IgM negative samples were analysed. Results: Compared with each laboratory's conventional methods, the tested assay had similar sensitivity and specificity (99.4% and 97.7%, respectively). Samples containing potentially interfering antibodies did not cause specificity problems. Conclusion: Regarding diagnosis of acute TBEV infections, ReaScan TBE offers rapid and convenient complementary IgM detection. If used as a stand-alone, it can provide preliminary results in a laboratory or point of care setting.

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  • Pegestam, Ebba
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Ingaröåsens lämplighet för återinfiltration av vatten från sjön Återvallsträsk, Värmdö kommun2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The question about groundwater in today’s society is a controversial subject where the current climate change leads to more extreme weather and the society has to increase the readiness to it. 

    Värmdö kommun has taken action to this and has given Geoveta the work to determine if it is possible to re-infiltrate water from the lake Återvallsträsk into the esker on Ingarö. This bachelor’s work is a small project within the larger one and aiming to investigate if the esker on Ingarö is suitable for re-infiltration from the lake Återvallsträsk. This work includes a literature study in order to get information about the structure of the esker and origin and problems linked to it used for landfills and gravel pits. It also includes a field study where soil and water samples were taken to be analyzed in a chemistry lab and for dry sieving to see what the samples contains and how the particle size distribution is formed. The material in the esker contains mostly sand and some gravel and the quality turned out fine. The quality in the lake turned out to not be so good, containing elevated levels of bacteria and organic material. 

    The conclusion is that the esker is suited for re-infiltration of lake water, but the lake needs to be continuously tested again and further analyzed and determine if the elevated levels of organic material and bacteria can be reduced. 

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  • Jim, Nilsson
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Fracture characterization in magmatic rock, a case study of the Sosa-dyke (Neuquén Basin, Argentina)2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    There are many examples worldwide were fossil magmatic intrusions influence the local water and energy supply. Due to that intrusions can act as a conductor and a reservoir, but also as a barrier for fluids and gases in the ground. The decisive feature between conductor or barrier in an intrusion is its fracture network. Hence it is of paramount importance to characterize an intrusion’s fracture network and thus its permeability. However, other than through boreholes magmatic intrusions are rather inaccessible and very little is known about their influence on aquifers and reservoir rocks in the underground. It is therefore important to increase the knowledge of magmatic intrusion by investigate the intrusions that are accessible for us at ground surface. In this study, photos from a case study about the Sosa dyke have been used to map and characterizes the fractures of the Sosa dyke, which is an accessible vertical magmatic intrusion and a part of the Chachahuén volcano complex in the southwestern parts of Argentina. The photos that were used are taken with an UAV (unmanned aerial vehicle), and to analyze the photos, map the fractures and produce the results, software as Agisoft Metashape, MOVE™ and MATLAB with the toolbox FracPaQ was used. The intrusion has two distinct fracture sets, one that is perpendicular to the intrusion margins and one that stretches parallel with the intrusion. The connectivity of the fractures is low, and since the permeability of the fractures largely depends on the connectivity, it is also low. The fracture set that is perpendicular to the intrusion margin is what’s called cooling fractures, which is created as the magma in the intrusion cools. This causes the magma to contract and break, forming fractures perpendicular to the inward migrating solidification front. The fracture set that is parallel with the intrusion is caused by minerals in the magma flow being affected by friction from the intrusion margins. This causes the minerals in the magma to elongate in the direction of flow along the sides of the dyke, creating foliation, enabling fractures to propagate along. These fracture sets are poorly connected which concludes that the mapped area of the Sosa-dyke has a low permeability.

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  • Persson Westin, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Tilting modules and exceptional sequences for leaf quotients of type A zig-zag algebras2020In: Beitraege zur Algebra und Geometrie, ISSN 0138-4821, E-ISSN 2191-0383, Vol. 61, no 2, p. 189-207Article in journal (Refereed)
    Abstract [en]

    We classify generalized tilting modules and full exceptional sequences for the family of quasi-hereditary quotients of type A zig-zag algebras and for a related family of algebras. We also give a characterization of these quotients as quasi-hereditary algebras with simple preserving duality that are "close" to self-injective algebras.

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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de caussis diminutionis contemtusque religionis, quam, consent. ampliss. facult. philosoph. ups. præside Mag. Joh. P. Sleincour, ... Stipendiarius Sollenianus, Elias Er. Waldius, fjerdhundrensis. In auditorio Gustaviano d. XI. junii, anno MDCCLXXIII.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de conjuctione cultus dei interni et externi, quam, ... præside Mag. Joh. Petro Sleincour, ... in Auditorio Gustaviano d. IX. Junii, Anno MDCCLXXIII. Horis post meridiem solitis publice examinandam sistit. V. D. M. Johannes Pertus Morenius, Nericius.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de ardenti studio defendendi jura divina, quam, consent. ampl. facult. philos. ups. præside, Mag. Johanne Petro Sleincour, ... Nicol. Bothv. Gladheim. Ostro-Gothus. In audit. Carol. maj. d. IX. Junii, anno MDCCLXXIII.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, discrimen virtutum moralium sistens, quam, consensu ampliss. facult. philosoph. præside Mag. Joh. Petro Sleincour, ... Petrus Regnell, ... Helsingus in audit. Car. min. die V. Junii a. MDCCLXXIII.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de cultu dei publico in vita civili utilissimo. Quam, consent. ampl. facult. philos. ups. præside, Mag. Joh. Petro Sleincour, ... Ericus Vilhelmus Nyberg, Uplandus. In auditor. Gustavian. die XXVIII. Maji, anno 1773.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Obligatio cognitionem alterius promovendi quam, dissertatione graduali, suffragante ampliss. ordine philosoph. in reg. acad. Upsal. præside mag. Johanne Petro Sleincour, ... In audit. Carol. major. d. 14 Maji, anno MDCCLXXIII. ... Petrus Juring. O. Gothus.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio, politico-moralis, demonstratura, ciceronem, neque cæsari, neque pompejo, sed saluti patriæ, in bello civili, fuisse addictum. Quam, consensu ampliss. facult. philosoph. ups. sub præsidio Mag. Joh. Petri Sleincour, ... Aron Dahlerus, ... Calmariensis. In audit. Carol. maj. d. V Maji, anno MDCCLXXIII.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio de emendatione morum politica. quam, venia ampliss. colleg. philosoph. in alma musarum sede upsaliensi, moderante Mag. Joh. Petro. Sleincour, ... In auditorio Carolino majori die XXIII. aprilis, anno MDCCLXXIII. ... alumnus piperianus, Laurentius Plaanander. Ostro-Gothus.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Ljunggren, Thure
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Specimen graduale, de pulchritudine morali, quod venia ampliss. ord. philosoph. ups. sub moderamine Mag. Joh. Petri Sleincour, ... In audit. Carol. maj. die [ ] April. anni MDCCLXXIII. ... Thuro Laur. Ljunggren, V-Gohtus.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio, de deismo, philosophiae moralis veritatibus inimico, quam, consent. ampl. facult. philos. ups. praeside Mag. Johanne Petro Sleincour, ... Andreas Er. Tegman, Uplandus[.] In auditorio Carolino majori die 7 Aprilis, anno 1773.1773Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis. monita quædam, circa pietatis et scelerum conjunctionem, quam consent. ampl. facult. philos. ups. præside, Mag. Joh. Petro Sleincour, ... Petrus Pet. Meurling. ostro-gothus. In audit. Carol maj. d. XVI. decemb. MDCCLXXII.1772Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Monita non nulla circa principium juris naturæ adnuente ampliss. ord. philosoph. ad reg. ups. acad. moderante Mag. Joh. Petro Sleincour, ... In auditorio Carol. majori ... die VIII Julii MDCCLXXII. Alumnus regius Carolus Falck, jemtlandus.1772Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de ordine servando in societate civili, quam, consensu ampliss. ord. philosophici in regia academia upsaliensi, præside. viro celeberrimo Mag. Joh. Petro Sleincour, ... Johannes Alex. Livin, Ostro-Gothus. In auditorio Carol. maj. die. 23. maji. 1772.1772Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio philosophica, sistens cogitationes nonnullas, de gustus varietate, ejusque usu politico, quam, consens. ampliss. colleg. philosoph. in regia academia upsaliensi, præside, Mag. Joh. Petro Sleincour, ... Stipendiarius Kåhreanus, Johannes David Rogberg, smolandus. In audit. Carol. maj. die XX. maji. a. MDCCLXXII.1772Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, jura et obligationes officalium, in republica, breviter tradens. Quam, ... præside, mag. Joh. Petro Sleincour, ... publico examini submittit Elavus Arrhenius, ... Wermelandus. In audit. Carol. maj. ad diem XIII. Maji. anni MDCCLXXII. horis ante meridiem solitis.1772Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, ostensura salutem publicam privatis commodis esse præferendam. Quam, consensu ampliss. facultat. philosoph. In regia academia Upsaliensi, præside, Mag Johanne Petro Sleincour, ... Stipendiarius Nesselianus, Ericus Erici Waldius. Fjerdhundrensis. In audit. Gustaviano d. XX novemb. MDCCLXXI.1771Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de objectis suffragiorum. Quam consensu amplissimi ordinis philosophici. In regia academia upsaliensi. Moderante Mag. Joh. Petro Sleincour. ... Stipendiarius Grönvallinnus. Johannes Schönberg, Dalekarlus. In audit. Gustav. d. XX. Junii, MDCCLXXI.1771Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio de scientia politica, ministro ecclesiæ necessaria quam suffragante amplis. ordine philosoph. incliti lycei Upsaliensis, præside vivo amplissimo atque celeberrimo Mag. Johanne Petro Sleincour, ... Publice ventilandam sistit Ericus Erlandus Ullman, Dalia Wermelandus[.] In audit. Car. maj. ad diem 19 Junii anno MDCCLXXI. Horis ante meridiem solitis.1771Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de libertate studiis litterarum necessaria, quam consensu amplissimi ordinis philosophici, in regia academia upsaliensi, moderante Mag. Joh. Petro Sleincour. ... Andreas Wigander, vestmannus. In audit. Gustav. d. XV. junii, MDCCLXX[!].1771Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, ostendens, cognitionem omnipræsentiæ divinæ optimum esse ad bene vivendum incitamentum, quam consensu ampliss. facult. philos. Ups. præside, Mag. Johanne Petro Sleincour ... Examinandam sistit, Fridericus Stenhagen, Ostrobothniensis. In auditorio Carolino majori, ad diem 8. Maji 1771.1771Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de usu juris naturalis in vita civili, quam ... præside ... Johanne Petro Sleincour ... examinandam sistit, Carolus Gustavus Nordin, Jemtlandus. In auditorio Carolino majori, ad diem 4. April. 1771.1771Dissertation (older thesis) (Other academic)
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  • Schroeder, Silvia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Approaching Female Genital Cutting/s on a Community-Based Level in Sweden: An Analysis of the Agenda-Setting Role of Swedish Civil Society Organisations2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The practice of female genital cutting/s (FGC) has been under national scrutiny in Sweden for decades. Besides strong laws and policies enforced by the Swedish government, civil society organisations have played an important role in addressing the subject of FGC in Sweden. The purpose of this research is to examine what roles and functions civil society organisations assume as they tackle the practice of FGC. Based on semi-structured interviews conducted with employees and volunteers from civil society organisations that address the practice on a daily basis, this study sheds light on the possibilities and challenges civil society organisations face when they approach the question of FGC in Sweden.

    This research finds that civil society organisations carry a lot of responsibility in terms of tackling FGC in Sweden, as governmental efforts are perceived to be insufficient. Criticism against the Swedish government is first and foremost directed to the lack of knowledge and understanding on FGC within authorities and to the lack of grassroot efforts together with diaspora communities. Thus, this examination shows how civil society organisations engage and provide complementary efforts. First, civil society organisations raise awareness and shed light on the complexity on the practice of FGC within several authorities to secure that knowledge about the practice is maintained. Second, civil society organisations strive to involve, engage and empower individuals on grassroot levels by creating safe and familiar spaces to talk about FGC. Finally, local efforts provided by civil society organisations aim to empower people affected by the practice of FGC to make their voices heard and to represent themselves. In conclusion, this research demonstrates that civil society organisations hold vital complementary roles in relation to the Swedish state in terms of addressing the practice of FGC in Sweden.                     

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  • Lewis, Matthew
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    A Conception of Human Dignity: A study about human dignity as a guiding moral principle in the implementation and conflict of human rights2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of this study is to develop a fruitful conception of human dignity, a conception that can be used as a guiding moral principle when trying to resolve the conflict of rights. Specifically, the question that this study attempts to answer is what is a fruitful conception of human dignity and how can it be used to deal with concrete issues pertaining to human rights? Two reports from special rapporteurs propose two different courses of action regarding the implementation of the right to protection of property, and this is the conflict that the proposed conception of human dignity tries to resolve. To develop a conception of human dignity a broad conception of human dignity is initially developed, through the usage of a Rawlsian reflective equilibrium, and it is further developed through a combination of a reflective equilibrium, examination of the conception in relation to overall coherence with the human rights tradition, and a consequence analysis. The latter is done by utilizing a consequence analysis with the aforementioned courses of action being applied in a specific case, the case of Tanzania.

    By using a consequence analysis, a proposed conception of human dignity and a reflective equilibrium the conception of human dignity could be developed further and contribute to resolve the specific conflict of rights that could be found in the reports of the special rapporteurs. The conclusion drawn was that both of the proposed courses of action, regarding the implementation of the right to the protection of property and in relation to the proposed conception of human dignity, had desirable and less desirable consequences. Therefore, a third way was proposed that sought to bridge the gap between both courses of action, by combining elements of both, and to strengthen the condition-dignity for the parties affected.

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  • Lanängen, Vera-Linn
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Att födas död: Skugginstitutionalism, Nekropolitik, Framing & Prekaritet2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis I examine precarity and necropolitics in the context of a religious institution namely the Jehovah’s witnesses. I specifically examine the conditions of LGBTI-children by the use of framing and the Jehovah’s witnesses own published material. I apply central concepts from Judith Butler’s and Achille Mbembe’s theories on precarity and necropolitics in order to explain what it means to not be born precarious and to explain Jehovah’s witnesses stand on homosexuality. I also develop and test my own theoretical framework that there are two types of institutions; institutions and shadow institutions in which death is distributed in the latter. I also develop a methodology from which these institutions can be distinguished.

     

    The results show that the theories of Judith Butler, Achille Mbembe and my own theory on shadow institutions are indeed compatible and are united in a sort of necroprecarity. My results also show that there is a way to distinguish totalitarian and extremist groups from democratic groups by the use of framing and my theory of shadow institutions. My thesis also highlights the importance of anti-integration for people existing in a non-living state.

     

    This thesis offers a new methodology and can therefore be seen as a first step towards knotting together groups and organizations such as political extremist groups, criminal gangs, dictatorships and religious cults under the umbrella of shadow institutions. Which by itself can be the foundation for a new field of research. By distinguishing institutions from shadow institutions this methodology can be seen as a tool to counteract anti-democratic movements in order to create a more peaceful and stable society.

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  • Göthberg, Rosalind
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Climate Justice and the Paris Agreement: Dimensions of Climate Justice in the Nationally Determined Contributions2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Climate change is a critical threat to all the countries of the world today, not least because of the severe human rights infringements it may well lead to. However, although climate change is a collective, global challenge, there are considerable inequalities regarding contribution to cause and burden of the effects. Those suffering the most from the effects of climate change tend to be least responsible for the emissions causing it. The theoretical concept of climate justice aims to address these injustices, between different countries as well as societal groups and generations. To contribute to the understanding of how this concept is present in the global climate debate today, this thesis examines a selection of the Paris Agreement parties’ Nationally Determined Contributions (NDCs) from a perspective of climate justice. The analysis is based on a theoretical framework developed by Andrea Schapper, focusing on three dimensions of climate justice – international, intra-societal and intergenerational. Through this framework, a total of 36 NDCs are studied, the top and bottom three countries for each world region based on levels of cumulative CO2-emissions. The aim of the case selection has been to obtain a variation regarding development status, vulnerability to the effects of climate change, levels of greenhouse gas emissions and geographical location of the studied countries.

    The results of the study show that all the dimensions are present in at least some of the studied NDCs, but to a very different extent. Primarily, the parties discuss the issue of international justice. Intra-societal justice is touched upon quite frequently but very few bring up the matter of intergenerational justice. Moreover, all three dimensions are predominantly handled by countries classified as ”developing” (according to the UN statistics division).  This implies that climate justice is a higher priority for the most vulnerable to and least responsible for climate change, which is problematic for many reasons. Above all, it indicates that rich, industrialized countries are reluctant to take responsibility for their current and historical emissions, as well as the effect those emissions have on others.

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  • Ljus, Simon
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Purging Sensitive Data in Logs Using Machine Learning2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates how to remove personal data from logs using machine learning when rule-based scripts are not enough and manual scanning is too extensive.

    Three types of machine learning models were created and compared. One word model using logistic regression, another word model using LSTM and a sentence model also using LSTM.

    Data logs were cleaned and annotated using rule-based scripts, datasets from various countries and dictionaries from various languages. The created dataset for the sentence based model was imbalanced, and a lite version of data augmentation was applied.

    A hyperparameter optimization library was used to find the best hyperparameter combination. The models learned the training and the validation set well but did perform worse on the test set consisting of log data from a different server logging other types of data.

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  • Andersson, Jakob
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Automatic Invoice Data Extraction as a Constraint Satisfaction Problem2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Invoice processing has traditionally been heavily dependent onmanual labor, where the task is to identify and move certaininformation from an origin to a destination. A time demandingtask with a high interest of automation to reduce time ofexecution, fault-risk and cost.With the evergrowing interest in automation and ArtificialIntelligence (AI), this thesis will explore the possibilities ofautomating the task of extracting and mapping information ofinterest by defining the problem as a Constraint OptimizationProblem (COP) using numeric relations between present information.The problem is then solved by extracting the numericalvalues in a document and utilizing it as an input space whereeach combination of numeric values are tested using a backendsolver.Several different models were defined, using different approachesand constraints on relations between possible existingfields. A solution to an invoice was considered correct if thetotal, tax, net and rounding amounts were estimated correctly.The final best achieved results were 84.30% correct and8.77% incorrect solutions on a set of 1400 various types of invoices.The achieved results show a promising alternative route toproposed solutions using e.g. machine learning or other intelligentsolutions using graphical or positional data. While only regardingthe numerical values present in each document, the proposedsolution becomes decentralized and therefor can be implementedand ran on any set of invoices without any pre-training phase.

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  • Eriksson, Agnes
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, The Social Sciences of Religion, Sociology of Religions.
    ”Religiösa friskolor blev en giftcocktail”: – Den svenska debatten om att förbjuda religiösa friskolor2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In March 2018 the Swedish Social Democratic Party presented the election promise to ban faith-based schools. This election promise evoked strong reactions and gave rise to a debate about the role of religion in Swedish schools in many Swedish newspapers. The aim of this bachelor thesis is to explore what arguments that have been utilized in the debate about faith-based schools. Debate articles are here examined using argumentation analysis: Dagens Nyheter, Svenska Dagbladet, Expressen and Aftonbladet. The results conclude that the most common arguments in favor of a ban on faith-based schools are: segregation, religious indoctrination, and serious shortcomings in said schools. From the other side of the debate, in defense of faith-based schools, the most common arguments are the following: integration, freedom of religion and high-quality education. An additional aim is to study these arguments using Hjelm’s (2014) explanations of the “New Visibility of Religion”. The analysis reveals that the debate is informed by a secular norm where religion is viewed as something unwelcome in the public eye. The debate is informed by a conflict of how religion ought to be valued, and if it should be viewed as a resource or a problem. Advocates in favor of a ban on faith-based schools claim that these schools constitute a social problem in contemporary society. Defenders of faith-based school, on the other hand, view them as a resource and argue that there today is a great need for faith-based schools. Rather than discussing faith, this debate deals mainly with the question of what role religion should play in today’s society. Religion is visible because it can be good or bad, something that Hjelm (2014) refers to as the ”secular return of religion”. Neoliberal reforms have changed the Swedish School system, which in turn affects the debate. This debate ultimately reveals a conflict of aims regarding the purpose of the Swedish school system and where equality is put against freedom of choice.

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  • Tanis, M. F. (Marco)
    et al.
    Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands.
    Marshall, Leon
    Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands;Univ Libre Bruxelles, Landscape Ecol & Plant Prod Syst LEPPS EIB, Agroecol & Pollinat Grp, Ave Franklin Roosevelt 50, B-1050 Brussels, Belgium.
    Biesmeijer, J. C. (Koos)
    Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands;Leiden Univ, Inst Environm Sci CML, Einsteinweg 2, NL-2333 CC Leiden, Netherlands.
    van Kolfschoten, Lisette
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands.
    Grassland management for meadow birds in the Netherlands is unfavourable to pollinators2020In: Basic and Applied Ecology, ISSN 1439-1791, E-ISSN 1618-0089, Vol. 43, p. 52-63Article in journal (Refereed)
    Abstract [en]

    Agricultural intensification and loss of semi-natural grassland have contributed to biodiversity decline, including pollinator species, in pastures around the world. To reverse the decline, agri-environmental schemes have been implemented, varying widely in effectiveness. In addition, many countries, including the Netherlands, have established nature reserves in which semi-natural grasslands are restored and are often managed for specific groups of species, e.g. meadow birds or plants. The effects of such measures on insect biodiversity are not well known but recent reports on the dramatic decline of insect biomass in nature reserves have put even more attention to the impact of land use and management on biodiversity. This study compares pollinator abundance and species richness in three common semi-natural grassland management types in the Netherlands: (1) hay meadows, (2) herb-rich grasslands and (3) meadow bird grasslands. Pollinator abundance and species richness were assessed in eleven study areas, each with all three management types present. Standardized transects, insect sampling within a standard 20 min time frame and plot-based flower surveys were used in spring and summer to assess the relationships between management regime, floral abundance and diversity and pollinator communities. The results show that meadow bird grasslands have lower pollinator abundance and diversity and a less unique pollinator assemblage than both other types. Moreover, flower abundance has a positive effect on pollinator abundance and flower diversity has a positive effect on pollinator species richness. These results indicate that meadow-bird grasslands are a comparatively unfavourable habitat for bees, hoverflies and butterflies, which may be explained by a lack of flowers as well as unsuitable mowing practices. Measures benefitting both insectivorous birds and flower-visiting insects, such as rotational mowing, could remediate this imbalance.

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  • Public defence: 2020-08-28 09:15 ITC 2446, Uppsala
    Olsson, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Inertial motion capture for ambulatory analysis of human movement and balance2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Inertial sensors (accelerometers and gyroscopes) are ubiquitous in today’s society, where they can be found in many of our everyday mobile devices. These sensors are capable of recording the movement of the device, and by extension, the movement of humans carrying or interacting with the device. Human motion capture is frequently used for medical purposes to assess individual balance performance and movement disorders. Accurate and objective assessment is important in the design of individualized interventions and rehabilitation strategies.

    The increasing availability of inertial sensors, combined with their mobility and low cost, has made inertial motion capture highly relevant as a more accessible alternative to the laboratory based gold standard. However, mobile solutions need to be adopted for plug-and-play use with the end user in mind. Methods that automatically calibrate the sensors, and methods that detect and record relevant motions are required.

    This thesis contributes to the development of human inertial motion capture as a plug-and-play technology. A method for accelerometer calibration, which allows for compensation of systematic sensor errors, is proposed. The method fuses accelerometer and gyroscope data to allow dynamic rotation of the sensor during the calibration procedure. Other proposed methods handles sensor-to-segment calibration in a biomechanical model. The position of a joint center and the direction of a hinge joint’s rotation axis, are identified in each sensor’s intrinsic coordinate system. This is done by fitting recorded motions to the kinematic constraints of the underlying biomechanical model. The methods are evaluated on real sensor data collected from mechanical joint systems that mimics human limbs.

    The state of the current knowledge regarding objective human balance assessment isstudied in the form of a systematic review, that includes methods for modeling and identifying neuromuscular control of human balance. A similar modeling framework is then applied to identify feedback controllers in physical and artificial (simulated) systems. Finally, inertial sensors are applied in tremor quantification in Parkinson’s disease (PD) and essential tremor (ET). The method uses only the inertial sensors in a standard smart phone, and is applied on data from human subjects with PD or ET.

    List of papers
    1. Accelerometer calibration using sensor fusion with a gyroscope
    Open this publication in new window or tab >>Accelerometer calibration using sensor fusion with a gyroscope
    2016 (English)In: Proc. 19th Statistical Signal Processing Workshop, Piscataway, NJ: IEEE, 2016, p. 660-664Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Piscataway, NJ: IEEE, 2016
    National Category
    Signal Processing
    Identifiers
    urn:nbn:se:uu:diva-308761 (URN)10.1109/SSP.2016.7551836 (DOI)000390840200132 ()978-1-4673-7803-1 (ISBN)
    Conference
    SSP 2016, June 26–29, Palma de Mallorca, Spain
    Projects
    CADICS
    Available from: 2016-08-25 Created: 2016-11-30 Last updated: 2020-05-04Bibliographically approved
    2. Experimental evaluation of joint position estimation using inertial sensors
    Open this publication in new window or tab >>Experimental evaluation of joint position estimation using inertial sensors
    2017 (English)In: Proc. 20th International Conference on Information Fusion, Piscataway, NJ: IEEE, 2017, p. 354-361Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Piscataway, NJ: IEEE, 2017
    National Category
    Control Engineering
    Identifiers
    urn:nbn:se:uu:diva-335035 (URN)10.23919/ICIF.2017.8009669 (DOI)000410938300052 ()978-0-9964-5270-0 (ISBN)
    Conference
    Fusion 2017, July 10–13, Xi'an, China
    Available from: 2017-08-15 Created: 2017-11-30 Last updated: 2020-05-04Bibliographically approved
    3. Robust Plug-and-Play Joint Axis Estimation Using Inertial Sensors
    Open this publication in new window or tab >>Robust Plug-and-Play Joint Axis Estimation Using Inertial Sensors
    (English)In: Article in journal (Other academic) Submitted
    Place, publisher, year, edition, pages
    Uppsala:
    National Category
    Control Engineering
    Identifiers
    urn:nbn:se:uu:diva-409893 (URN)
    Funder
    Swedish Research Council, 2015-05054
    Available from: 2020-05-04 Created: 2020-05-04 Last updated: 2020-05-04
    4. Neuromuscular controller models for quantifying standing balance in older people: A systematic review
    Open this publication in new window or tab >>Neuromuscular controller models for quantifying standing balance in older people: A systematic review
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Control Engineering
    Identifiers
    urn:nbn:se:uu:diva-409890 (URN)
    Funder
    Swedish Research Council, 2015-05054
    Available from: 2020-05-04 Created: 2020-05-04 Last updated: 2020-05-04
    5. Identification of nonlinear feedback mechanisms operating in closed loop using inertial sensors
    Open this publication in new window or tab >>Identification of nonlinear feedback mechanisms operating in closed loop using inertial sensors
    2018 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    In this paper we study the problem of identifying linear and nonlinear feedback mechanisms, or controllers, operating in closed loop. A recently developed identification method for nonlinear systems, the LAVA method, is used for this purpose. Identification data is obtained from inertial sensors, that provide information about the movement of the system, in the form of linear acceleration and angular velocity measurements. This information is different from the information that is available to the controller to be identified, which makes use of unknown internal sensors instead. We provide two examples, a simulated neuromuscular controller in standing human balance, and a lead-filter controlling a physical position servo using a DC motor. Both linear and nonlinear controllers are used in the examples. We show that the LAVA method is able to identify sparse, parsimonious models of the controllers.

    Place, publisher, year, edition, pages
    IFAC Papers Online, 2018
    Series
    IFAC-PapersOnLine, ISSN 2405-8963 ; 51:15
    National Category
    Control Engineering
    Identifiers
    urn:nbn:se:uu:diva-350607 (URN)10.1016/j.ifacol.2018.09.190 (DOI)000446599200081 ()
    Conference
    18th IFAC Symposium on System Identification (SYSID), Stockholm, Sweden, 9–11 July, 2018
    Funder
    Swedish Research Council, 2015-05054
    Available from: 2018-10-08 Created: 2018-05-14 Last updated: 2020-05-04Bibliographically approved
    6. Nonparametric time-domain tremor quantification with smart phone for therapy individualization
    Open this publication in new window or tab >>Nonparametric time-domain tremor quantification with smart phone for therapy individualization
    2020 (English)In: IEEE Transactions on Control Systems Technology, ISSN 1063-6536, E-ISSN 1558-0865, Vol. 28, no 1, p. 118-129Article in journal (Refereed) Published
    Abstract [en]

    This paper deals with a low-complexity time-domain tremor quantification method for individualization of therapies in medical conditions, where tremor is a cardinal symptom. This method produces a tremor severity estimate based on the measurements acquired from a standard sensor platform of a smart phone during a smooth voluntary movement. The estimate is calculated from a data set recorded over tens of seconds but can also be used for unobtrusive tremor monitoring over long time. Besides tremor amplitude, its frequency is also evaluated over time, thus providing the means to distinguish between, e.g., rest and action tremor. No analytical model is assumed for the tremor signal form. The characterization of tremor severity is performed by the steady-state analysis of a Markov chain, whose states correspond to different intervals of tremor amplitude. The utility of the proposed quantification approach is illustrated by clinical data obtained during Deep Brain Stimulation programming sessions. The results are compared with a conventional approach utilizing spectral analysis to demonstrate the benefits of the proposed method.

    Keywords
    Satellite broadcasting, Smart phones, Medical treatment, Accelerometers, Time-domain analysis, Spectral analysis, Gyroscopes, Biomedical systems, essential tremor (ET), inertial sensors, Markov models, nonparametric modeling, Parkinson's disease (PD), therapy individualization
    National Category
    Control Engineering
    Identifiers
    urn:nbn:se:uu:diva-398281 (URN)10.1109/TCST.2018.2881420 (DOI)000505786600009 ()
    Funder
    Vinnova
    Available from: 2018-12-07 Created: 2019-12-04 Last updated: 2020-05-04Bibliographically approved
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  • Alajlani, Muaaz Mutaz
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Univ Halle Wittenberg, Inst Pharm, Dept Pharmaceut Biol Pharmacognosy, Hoher Weg 8, DE-06120 Halle, Saale, Germany..
    Backlund, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Evaluating Antimycobacterial Screening Schemes Using Chemical Global Positioning System-Natural Product Analysis2020In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 25, no 4, article id 945Article in journal (Refereed)
    Abstract [en]

    Most of the targeted discoveries in tuberculosis research have covered previously explored chemical structures but neglected physiochemical properties. Until now, no efficient prediction tools have been developed to discriminate the novelty of screened compounds at early stages. To overcome this deficit, a drastic novel approach must include physicochemical properties filters provided by Chemical Global Positioning System-Natural Product analysis (ChemGPS-NP). Three different screening schemes GSK, GVKBio, and NIAID provided 776, 2880, and 3779 compounds respectively and were evaluated based on their physicochemical properties and thereby proposed as deduction examples. Charting the physiochemical property spaces of these sets identified the merits and demerits of each screening scheme by simply observing the distribution over the chemical property space. We found that GSK screening set was confined to a certain space, losing potentially active compounds when compared with an in-house constructed 459 highly active compounds (active set), while the GVKBio and NIAID screening schemes were evenly distributed through space. The latter two sets had the advantage, as they have covered a larger space and presented compounds with additional variety of properties and activities. The in-house active set was cross-validated with MycPermCheck and SmartsFilter to be able to identify priority compounds. The model demonstrated undiscovered spaces when matched with Maybridge drug-like space, providing further potential targets. These undiscovered spaces should be considered in any future investigations. We have included the most active compounds along with permeability and toxicity filters as supplemented material.

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  • Staffansson Pauli, Karin
    et al.
    Malmö Univ, Dept Urban Studies, S-20506 Malmö, Sweden.
    Liu, Ju
    Malmö Univ, Dept Urban Studies, S-20506 Malmö, Sweden.
    Bengtsson, Bo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Housing and Urban Research. Malmö Univ, Dept Urban Studies, S-20506 Malmö, Sweden.
    Sustainable Strategy in Housing Renovation: Moving from a Technology-and-Engineering-Focused Model to a User-Oriented Model2020In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 12, no 3, article id 971Article in journal (Refereed)
    Abstract [en]

    Housing renovation, in contrast to new construction projects, has to take good care of the tenants who are already living in the building. What are the theoretical and practical implications concerning the transformation from a technology-and-engineering-focused renovation approach to a more user-oriented one? What are the mechanisms of strategy change? Based on our case we argue that the mechanisms of strategy change are based on the interplay between external disturbance and internal renewal. External disturbance is the trigger of strategy change, but it does not, in itself, necessarily lead to strategy change, and particularly not for an innovative new strategy. The internal new competence is the source of changing from an old strategy to an innovative new strategy. The real estate industry needs to undergo a transformation from the rationalistic technology- and engineering-focused renovation model (TEF model) to a more inclusive approach. We suggest a user-oriented model (UO model) where user involvement is seen as integrated in the whole process of renovation.

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  • Pan, Gang
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Cavalli, Marco
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Carlsson, Björn
    AstraZeneca, Res & Early Dev, Cardiovasc Renal & Metab, BioPharmaceut R&D, Gothenburg, Sweden.
    Skrtic, Stanko
    AstraZeneca AB, Pharmaceut Technol & Dev, Gothenburg, Sweden;Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
    Kumar, Chanchal
    AstraZeneca, BioPharmaceut R&D, Translat Sci & Expt Med, Res & Early Dev,Cardiovasc Renal & Metab CVRM, Gothenburg, Sweden;Karolinska Inst, AstraZeneca Integrated CardioMetab Ctr KI AZ ICMC, Dept Med, Huddinge, Sweden.
    Wadelius, Claes
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression2020In: iScience, ISSN 2589-0042, Vol. 23, no 2, article id 100808Article in journal (Refereed)
    Abstract [en]

    Long-chain polyunsaturated fatty acids (LC-PUFAs) influence human health in several areas, including cardiovascular disease, diabetes, fatty liver disease, and cancer. ELOVL2 encodes one of the key enzymes in the in vivo synthesis of LC-PUFAs from their precursors. Variants near ELOVL2 have repeatedly been associated with levels of LC-PUFA-derived metabolites in genome-wide association studies (GWAS), but the mechanisms behind these observations remain poorly defined. In this study, we found that rs953413, located in the first intron of ELOVL2, lies within a functional FOXA and HNF4α cooperative binding site. The G allele of rs953413 increases binding of FOXA1/FOXA2 and HNF4α to an evolutionarily conserved enhancer element, conferring allele-specific upregulation of the rs953413-associated gene ELOVL2. The expression of ELOVL2 was significantly downregulated by both FOXA1 and HNF4α knockdown and CRISPR/Cas9-mediated direct mutation to the enhancer element. Our results suggest that rs953413 regulates LC-PUFAs metabolism by altering ELOVL2 expression through FOXA1/FOXA2 and HNF4α cooperation.

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  • Aronsson, Gabriella
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Ågren, Hampus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Self-Assessed Anxiety and Physical Fitness in South African University Students: In collaboration with the Department of Physiotherapy, University of the Western Cape2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Background/problem definition: Mental illness, such as anxiety, is a health problem affecting about 10-20% of adolescents worldwide. Studies have found a person’s physical fitness to be associated with their mental health, but most studies have been done in the western world and few have investigated sub-Saharan African (SSA) countries. It has also been found that SSA countries’ guidelines regarding physical activity are few and incomplete, although the importance of it is well known.

     

    Aim: To investigate to what extent physical fitness: grip strength (GS), 20 meter shuttle run test (20MSRT), body mass index (BMI) and waist circumference (WC) correlate to self-assessed anxiety in South African students at the UWC.

     

    Methods: The study had a quantitative, cross-sectional and correlational research design with a non-randomized convenience sampling. The physical fitness data were collected through a hydraulic grip strength dynamometer, 20MSRT and by measuring anthropometric measurements in order to calculate BMI and WC. An electronic version of the GAD-7 form was used for self-assessed anxiety.

     

    Results: The results showed a significant positive correlation between BMI and levels of anxiety in women, but not in men. The correlation of anxiety related to WC, GS and 20MSRT showed no significance for the whole sample or related to gender, respectively.

    Conclusion: No significant correlation could be determined between physical fitness and anxiety. Severe anxiety affected 25% of the population, supporting previous research indicating that students are a group prone to anxiety.

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  • Krönström, Tobias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Forever young: A study of the correspondence between sculptures of Aphrodite and Venus and the female physical ideal in ancient literature2020Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    This study aims to explore how the goddesses of beauty Aphrodite and Venus were portrayed in sculpture in comparison to physical beauty, as attested in ancient texts. The study uses iconography and iconology to analyse the sculptures and semiotics to analyse the ancient texts. In this study measurements were taken of Aphrodite and Venus sculptures at Berlin’s plaster museum (Abguss-Sammlung Antiker Plastik). The measurements were taken in order to compare the results from the ancient texts. In this study, 11 sculptures are analysed and compared to ancient texts from five different periods (700-400 BC, 400-1 BC, 1-200 AD, 200-500 AD and unknown dates). The sculptures and the ancient texts are then compared to each other and then compared with modern studies about nakedness, physical appearance and beauty during antiquity. The results conclude that it is difficult to specify exact beauty ideals, but the study shows that women should be curvy, white and rosy, have firm breast and a lovely face, and that the sculptures follow that beauty ideal closely.

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  • Stumle, Per
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Studies in Faith and Ideologies, Systematic Theology and Studies in World Views.
    Du med ditt blod, din bittra död, befriar oss från synd och nöd.: Försoningslära i Kyrkohandbok för Svenska kyrkan2020Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis examines atonement theology in the Church of Swedens missal (Kyrkohandbok för Svenska kyrkan) published in 2018. By identifying atonement motifs the thesis identifies and discusses which types of atonement theology that dominates the missal. Four subquestions are used to identify and discuss the atonement theology expressed; Why is atonenment needed? What is atonement? How is atonement acheived? Is there potentially problematic aspects of the atonoment theology that is identified? The atonement theology which is identified is mainly of two sorts. The healing process and the atoning obedience.The thesis then tries to handle one such problematic aspect by discussing how to understand the concept of sacrifice which is central to the atoning obedience and by integrating the atonement theology of divinization, theosis, into the understanding of atonement that is dominant in the missal of the Church of Sweden. The thesis argues that properly understood, sacrifice and divinization offers a way forward in order to understand the theology of atonement in a way both true to the christian tradition and and comprehendible to society in the 21st century.

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  • Public defence: 2020-08-28 09:00 A1:111a, Uppsala
    Gynnå, Arvid H.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Bacterial DNA repair and molecular search2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Surveillance and repair of DNA damage is necessary in all kinds of life. Different types of DNA damage require different repair mechanisms, but these mechanisms are often similar in all domains of life. The most serious type of damage, double stranded DNA breaks, are for example repaired in conceptually similar ways in both bacteria and eukaryotes. When this kind of breaks are repaired by homologous recombination, a homology to the site of the break must be found. Sometimes, this homology can be located far away from the break necessitating a search. Considering the large amount of heterologous DNA present, the complexity of this search is enormous. If and how this search can proceed has been unclear even in simple and well characterized organisms as E. coli.

    In this thesis, microscopy together with microfluidics are used to show that DNA repair by homologous recombination occurs even between homologies separated by several micrometers. We also see that it finishes well within the time of a cell generation, with the enigmatic search phase being as quick as eight or possibly even three minutes. Since this time is much faster than expected, we present a physical model demonstrating how homology search on this time scale is indeed plausible. Based on these results, we conclude that homologous repair using distantly located templates is likely to be a physiologically relevant mechanism of DNA repair.

    Microscopy together with image analysis by deep learning also provides a new method of detecting DNA damage in real time. Combined with tracking of cell lineages, it reveals that DNA damage in E. coli is repaired efficiently enough that the resulting fitness cost is close to none. With the same methods we also study the effect of deletions of several DNA repair enzymes, and largely confirms their previous characterizations. Among these, we confirm that the intriguing RecN protein is important but not absolutely necessary in DSB repair, that it acts early, and possibly aids in physically shaping the structure mediating the search.

    In addition to this, it is shown how DNA transcription and translation modulates the shape of the E. coli nucleoid. We observe how strong a transcription of a gene within a few minutes moves the gene towards the periphery of the cell where the concentration of ribosomes is higher, a movement possibly also aided by protein translation.

    We also present MINFLUX, a microscope for both nanometer scale localization of single fluorophores as well as in vivo single particle tracking with unprecedented trace length and resolution. Using this, the E. coli small ribosomal subunit could be observed to quickly shift between fast and slow diffusion states which might represent probing and discarding of RNAs suitable for translation.

    List of papers
    1. RecA mediated homology search finds segregated sister locus in minutes after a double stranded break
    Open this publication in new window or tab >>RecA mediated homology search finds segregated sister locus in minutes after a double stranded break
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The search for a homologous template is a central and critical step in the repair of DNA breaks by homologous recombination. However, it is still unclear how the search process is carried out within a cell. Here, we image double-stranded break (DSB) repair in living E. coli growing in a microfluidic device and show that two segregated homologous sequences find each other less than 9 min after an induced DSB. To characterize the mechanisms of the search process, we use a new RecA fluorescent fusion that rapidly forms structures after DSBs. Initially, RecA forms a bright cluster at the site of the DNA damage and then extends to form a thin, flexible, and dynamic filament. Based on our observations, we propose a model where the 1D ssDNA-RecA filament stretches along the cell, and the homology search is mediated by diffusion of the repair template that can interact with any segment of the filament. This model reduces the complexity of the search from 3D to 2D and quantitatively predicts that genome-wide search for homology can be finished in minutes, in agreement with our measurements.

    National Category
    Bioinformatics and Systems Biology
    Research subject
    Microbiology; Biology with specialization in Molecular Biotechnology
    Identifiers
    urn:nbn:se:uu:diva-409996 (URN)10.1101/2020.02.13.946996 (DOI)
    Available from: 2020-05-06 Created: 2020-05-06 Last updated: 2020-05-08Bibliographically approved
    2. Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E. coli
    Open this publication in new window or tab >>Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E. coli
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    2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 5131Article in journal (Refereed) Published
    Abstract [en]

    Transcription by RNA polymerase (RNAP) is coupled with translation in bacteria. Here, we observe the dynamics of transcription and subcellular localization of a specific gene locus (encoding a non-membrane protein) in living E. coli cells at subdiffraction-limit resolution. The movement of the gene locus to the nucleoid periphery correlates with transcription, driven by either E. coli RNAP or T7 RNAP, and the effect is potentiated by translation.

    Place, publisher, year, edition, pages
    NATURE PUBLISHING GROUP, 2019
    National Category
    Biochemistry and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-398017 (URN)10.1038/s41467-019-13152-y (DOI)000495858500012 ()31719538 (PubMedID)
    Available from: 2019-12-04 Created: 2019-12-04 Last updated: 2020-05-07Bibliographically approved
    3. Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes
    Open this publication in new window or tab >>Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes
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    2017 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 355, no 6325, p. 606-612Article in journal (Refereed) Published
    Abstract [en]

    We introduce MINFLUX, a concept for localizing photon emitters in space. By probing the emitter with a local intensity minimum of excitation light, MINFLUX minimizes the fluorescence photons needed for high localization precision. In our experiments, 22 times fewer fluorescence photons are required as compared to popular centroid localization. In superresolutionmicroscopy, MINFLUXattained similar to 1-nanometer precision, resolving molecules only 6 nanometers apart. MINFLUX tracking of single fluorescent proteins increased the temporal resolution and the number of localizations per trace by a factor of 100, as demonstrated with diffusing 30S ribosomal subunits in living Escherichia coli. As conceptual limits have not been reached, we expect this localization modality to break new ground for observing the dynamics, distribution, and structure of macromolecules in living cells and beyond.

    National Category
    Biophysics
    Identifiers
    urn:nbn:se:uu:diva-317586 (URN)10.1126/science.aak9913 (DOI)000393636700043 ()28008086 (PubMedID)
    Funder
    EU, European Research CouncilKnut and Alice Wallenberg Foundation
    Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2020-05-07Bibliographically approved
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  • Bissi, Agnese
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Dey, Parijat
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Hansen, Tobias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Dispersion relation for CFT four-point functions2020In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 4, article id 92Article in journal (Refereed)
    Abstract [en]

    We present a dispersion relation in conformal field theory which expresses the four point function as an integral over its single discontinuity. Exploiting the analytic properties of the OPE and crossing symmetry of the correlator, we show that in perturbative settings the correlator depends only on the spectrum of the theory, as well as the OPE coefficients of certain low twist operators, and can be reconstructed unambiguously. In contrast to the Lorentzian inversion formula, the validity of the dispersion relation does not assume Regge behavior and is not restricted to the exchange of spinning operators. As an application, the correlator < phi phi phi phi > in phi (4) theory at the Wilson-Fisher fixed point is computed in closed form to order (2) in the E expansion.

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  • Li, Ka Lok
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics. Dublin Inst Adv Stud, Geophys Sect, Sch Cosm Phys, Dublin, Ireland..
    Gudmundsson, Ólafur
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    A Probabilistic Tremor Location Method2020In: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 47, no 4, article id e2019GL085538Article in journal (Refereed)
    Abstract [en]

    A method to locate tremor with an unclear onset is introduced. The method maps envelopes of cross-correlated records from pairs of seismographs to signal likelihoods using Bayes' theorem. The likelihood time series are then back projected to obtain likelihoods of source location in space. Assuming that information derived from different station pairs is independent, the joint likelihood for all station pairs is the product of all individual station pair likelihoods. Its peak and spread give the most probable source location and its uncertainty. Robustness of the method has been evaluated with synthetic tests. The method recovers true location within 0.5 km with realistic noise characteristics in synthetic data. Uncertainty estimates are consistent with location deviations for sources inside the seismic network. When applied to real data from Katla and Eyjafjallajokull volcanoes in southern Iceland, their likely tremor source is also recovered within 1 km. Plain Language Summary Locating seismic sources is an important task in seismology. An accurate location of a volcanic event, for example, helps to understand processes within the volcano and sometimes to predict an eruption. Unlike earthquakes that usually manifest themselves as impulses in seismograms, many Earth processes, for example, continuous volcanic tremor, produce complex seismic signals without a clear onset. The timing of such processes cannot be measured. Therefore, traditional earthquake location methods fail. This article introduces a method to locate such processes. It maps the likelihood that a source occurs at any given location based on correlations of tremor recordings that are sensitive to the difference in propagation times of waves from the source to the two correlated recorders. The peak of this map is where the source location is most likely and its width provides information about its uncertainty. This is a major advance since most methods only yield an estimate of the location, not its uncertainty. The method has been tested with synthetic data that simulate realistic observational geometry and noise processes at volcanoes and is able to recover the true source location to within half a kilometer. Applications to real data at Katla and Eyjafjallajokull volcanoes in southern Iceland indicate similar accuracy.

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