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  • Lagvik, Christer
    Uppsala University, University Library.
    Lagvik, Christer
    Uppsala University, University Library.
    Uppföljning av Riksbankens Jubileumsfonds riktlinjer för öppen tillgång2017Report (Other (popular science, discussion, etc.))
  • Eriksson, Amanda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Eriksson, Amanda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Pentilä, Victoria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Tiden sätter inga absoluta gränser: En enkätstudie om hur mellanchefer hanterar sin flexibla arbetstid2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte var att bidra med kunskap om hur mellanchefer av olika kön hanterar sin flexibla arbetstid. Utifrån syftet skapades tre frågeställningar; “Finns det någon skillnad mellan hur mellancheferna av olika kön planerar sin flexibla arbetstid?”, “I vilken utsträckning upplever mellancheferna av olika kön att de har kontroll över sin flexibla arbetstid?” och “I vilken utsträckning upplever mellancheferna av olika kön att det finns en konflikt mellan arbete och familj/fritid?”. Studiens empiri samlades in genom en enkätundersökning, respondenterna bestod av 44 mellanchefer med flexibel arbetstid från fyra olika enheter med viss geografisk spridning i Sverige. Studiens resultat har analyserats genom jämförelser mot tidigare forskning inom områdena det gränslösa arbetet, strategier för gränsdragning och mellanchefens gränsdragningar. Vidare har studiens teoretiska utgångspunkter genusordning, flexibel arbetstid samt dimensionen kontroll i Karasek och Theorells krav/ kontrollmodell, bringat förståelse för resultaten. Studiens resultat visade att det inte finns några markanta skillnader mellan hur de olika könen hanterar den flexibla arbetstiden. Däremot bör det understrykas att respondenterna som deltog i enkätundersökningen bestod av 73 procent kvinnor och 27 procent män. Resultaten indikerade istället att det fanns två möjliga förklaringar till andra uppvisade skillnader. Endera var det beroende av mellanchefens familjeförhållande, vilket i sin tur ledde till användandet av olika strategier. Eller så var skillnaderna beroende av mellanchefsrollen, vilken anses vara en position som präglas av snabba beslut samt arbetsuppgifter vilka är obegränsade till antalet.

  • Nessvi, Anton
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Nessvi, Anton
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    ”I have spent my life building bridges and tearing down barriers - not building walls”: – en kvalitativ innehållsanalys av debatten om Donald Trump2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Donald Trump’s candidacy for president has led to a substantial debate not only in the Republican party but also in the media. Using a two-dimensional theoretical model consisting of the left-right scale and the GAL-TAN scale, this study aims to review the conflict that Donald Trump’s campaign has led to in the Republican party.

    Using content analysis, a range of statements from Republicans have been analyzed, aiming to answer the following questions; How do the republican political actors contend for or against Donald Trump’s candidacy? and: what material or post-material values are linked to these arguments and statements?

    This study shows that the conflict following Donald Trump’s candidacy can mainly be placed in the post-material conflict dimension, even though some left-right arguments can also be found in the studied material. The political actors supporting Trump’s candidacy are mainly using arguments possible to place in the TAN-part of the post-material conflict dimension, whereas the actors criticizing Trump are mainly using arguments possible to place in the GAL-part. 

  • Mattsson, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Mattsson, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Implementering av resolution 1325: En studie om den jämlika representationens och närvaropolitikens påverkan på implementeringen av resolution 13252017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    This thesis analyses the implementation of United Nations Security Council’s resolution (UNSCR) 1325 in Rwanda and Sierra Leone. This research is interested in whether equal representation and political of presence has an impact on the implementation of the resolution. The countries different parliamentary gender distribution shall there of illustrate if that is the case. The findings have been analysed with a public-policy-analysis approach through the lens of implementation theory’s. What can be concluded from this research are a correlation between high proportion of female parliamentarians and a successful implementation.

  • Josefsson, Jakob
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Josefsson, Jakob
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    De policyprofessionella och ansvarsutkrävande: En teoretisk fortsättning på den explorativa ansatsen om de policyprofessionella2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Aktörer som kan utöva offentlig makt utan ha blivit framröstade i demokratiska val har länge intresserat statsvetare, och under de senaste åren har intresset dessutom spridit sig utanför den akademiska världen. Boken ”Makt utan mandat” är ett av de senaste bidragen till forskningsfältet. I boken presenteras den sociala och politiska kategorin ”policyprofessionella”, som utgörs av en samling aktörer från olika organisationstyper som alla har anställt för att bedriva politik. Dessa aktörer har ökat i antal och deras verksamhet påvisas vara ett potentiellt problem, delvis därför att det är svårt att utkräva ansvar dem. Denna uppsats är en metodologisk undersökning av hur lämpligt begreppet ”policyprofessionella” är för att beskriva problem med att utkräva ansvar av aktörer som anställt för att bedriva politik. Detta har gjorts genom att jämföra den kritik som presenteras i ”Makt utan mandat” med tidigare forskning på området, för att finna vad som är nytt med kritiken. Resultaten av denna jämförelse visar att innehållet i den kritik som har med ansvarsutkrävande att göra inte skiljer sig nämnvärt från den kritik som presenteras i tidigare forskning. Däremot är det omfång aktörer som tillsammans utgör de policyprofessionella ovanligt stort. Med hjälp av Ahlbäck Öbergs tre förutsättningar för ansvarsutkrävande har lämpligheten i att använda detta stora omfång prövats. Resultaten av denna prövning visar att det finns problem gällande ansvarsutkrävande för alla de aktörer som tillsammans utgör de policyprofessionella, men att det kan bli missvisande att tala om ett gemensamt problem för alla policyprofessionella. Begreppet ”policyprofessionella” kan alltså anses vara lämpligt, men med vissa förbehåll. 

  • Forsberg, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Forsberg, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Genusframställning i svenska skolsångböcker: En studie av Sjung Svenska Folk 1959-19892016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna studie är att studera genusframställningen i skolsångböcker under tidsperioden 1959-1989. Genom textanalys av sångboksserien Sjung Svenska Folk ska skillnader mellan hur de båda könen framställs påvisas. I studien görs detta utifrån samhällets förväntningar på manliga och kvinnliga egenskaper, yrkesutövning samt maktförhållandet mellan könen. Skolsångböcker har historiskt sett haft en viktig betydelse i förmedlandet av värderingar och i formandet av framtidens samhällsmedborgare. Utifrån analys av sångtexter från fyra olika decennier kan en tydlig skillnad observeras i hur kön framställts. Analysen i studien utgår från tre olika analytiska teman; yttre egenskaper, yrkesutövning och sysslor, samt maktförhållande. Slutsatsen som kan göras utifrån genomförd studie är att Sjung svenska folks sångtexter tydligt är förmedlare av samhällets förväntningar på män och kvinnor, en tydlig genusframställning görs i Sjung svenska folk. Denna framställning medför en reproduktion av genus i form av förväntningar på ett visst köns yttre egenskaper, yrkesutövning och sysslor samt maktförhållandet gentemot det andra könet under respektive decennium. Dock har intressanta avvikelser iakttagits för hur genusframställning skett under de fyra decennierna. Denna avvikelse kan bland annat härledas till 70-talet och framåt.

  • Westin Tikkanen, Karin
    University of Gothenburg, Dept. of Languages and Literatures.
    Westin Tikkanen, Karin
    University of Gothenburg, Dept. of Languages and Literatures.
    On the Building of a Narrative: The Ver Sacrum Ritual2016In: Mnemosyne (Lugduni Batavorum. Print), ISSN 0026-7074, E-ISSN 1568-525X, 1-19 p.Article in journal (Refereed)
    Abstract [en]

    The ver sacrum ritual remains a riddle in the early history of the Apennine peninsula. Several ancient Roman as well as Greek sources use the ritual in explaining Samnite movements across the peninsula, as ritual group expulsion of settlers sent out to colonize new lands. In short, this becomes the narrative ‘plot’ of archaic colonization.The ritual is however described very differently in the different sources, with regard to detail and to the plot elements involved in the tale. This article explores the various layers in the rendering of the ritual, and the different voices that take part in forming the ver sacrum narrative. With this perspective the ver sacrum becomes an expanded testimony of a tradition, used by different authors to stress various elements of their own historical reports.

  • Nordgren Nordgren, Nils
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Nordgren Nordgren, Nils
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Funkquist Nyborg, Nisse
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ord står mot ord: En kritisk diskursanalys av ärenden rörande kränkande behandling på grundskolor i Uppsala kommun 20162017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this paper was to examine how the bullying discourse differs depending on if the person bullying is a student or an employee at the school. Cases from Skolinspektionen and Barn- och elevombudsmannen was analysed using Faircloughs three dimensional critical discourse analysis to be able to identify how the disocurse differs depending on who has been bullying. The analysis showed that the discourse do differ between when it is a student and when it is a employee at the school that bullies. The agency of the employees were hidden and their potentielly bully-like actions were rationalized while the agency of students that bully was clear.

  • Söderberg, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Söderberg, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Browsing the Web of Amplitudes2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    We begin by studying field-theory amplitude relations such as the Kleiss-Kuijf, Bern-Carrasco-Johansson, Kawai-Lewellen-Tye and the double copy construction, which are important ingredients in this thesis. Going beyond the field-theory limit we study how the gauge-sector of the heterotic string relates to type I amplitudes through the single valued projection of multiple zeta values. At low energy and for a U(1) gauge group (a single brane) the type I amplitudes are generated by the Born-Infeld action, whereas the corresponding heterotic amplitudes vanish in this limit. As a simple exercise we study Yang-Mills theory deformed by a $F^4$ operator, which is the first correction induced by the Born-Infeld action. This exercise is then generalized by considering the four- and six-point amplitudes in Tseytlin's proposal for a non-Abelian Born-Infeld action. Comparing these amplitudes with those found in type I and heterotic string theory we attempt to gain more insight about the non-Abelian Born-Infeld action.

  • Jacobson, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Jacobson, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Self-ownership and the Foundations of Libertarianism: Applying Kymlicka’s Arguments on Geolibertarianism2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Löfgren, Linnéa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Löfgren, Linnéa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Kritiska medborgare och anställningsbara arbetare: Om gymnasieskolans demokratiuppdrag och skillnader mellan yrkes- och studieförberedande program2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Wang, Haidong
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bhutta, Zulfiriar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Diallo, Khassoum
    WHO Reg Off Europe, Copenhagen, Denmark..
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Fraser, Maya
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Fullman, Nancy
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Kita, Maaya
    Univ Tokyo, Grad Sch Med, Dept Global Hlth Policy, Tokyo, Japan..
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Juan
    Sichuan Univ, West China Univ Hosp 2, Natl Off Maternal & Child Hlth Surveillance, Chengdu, Peoples R China..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lind, Margaret
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Mensah, George A.
    NHLBI, Ctr Translat Res & Implementat Sci, NIH, Bldg 10, Bethesda, MD 20892 USA..
    Mikesell, Joseph B.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Rakovac, Ivo
    WHO Reg Off Europe, Copenhagen, Denmark..
    Salomon, Joshua A.
    Harvard Univ, Dept Global Hlth & Populat, Boston, MA 02115 USA..
    Silpakit, Naris
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Sligar, Amber
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Sorensen, Reed J. D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Zhu, Jun
    Natl Off MCH Surveillance China, Chengdu, Peoples R China..
    Abajobir, Amanuel Alemu
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Univ Queensland, Sch Publ Hlth, Herston, Qld, Australia..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abdulle, Abdishakur M.
    New York Univ Abu Dhabi, Abu Dhabi, U Arab Emirates..
    Abera, Semaw Ferede
    Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia.;Kilte AwlaeloHealth & Demog Surveillance Site, Mekelle, Ethiopia.;Univ Hohenheim, Food Secur, Stuttgart, Germany.;Univ Hohenheim, Inst Biol Chem & Nutr, Stuttgart, Germany..
    Aboyans, Victor
    Dupuytren Univ Hosp, Limoges, France..
    Abraham, Biju
    NMSM Govt Coll Kalpetta, Kalpetta, Kerala, India..
    Abubakar, Ibrahim
    UCL, Inst Global Hlth, London, England..
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar..
    Abu-Rmeileh, Niveen M. E.
    Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Abyu, Gebre Yitayih
    Mekelle Univ, Mekelle, Ethiopia..
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adelekan, Ademola Lukman
    Univ Ibadan, Ibadan, Nigeria.;Publ Hlth Promot Alliance, Osogbo, Nigeria..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Ajala, Oluremi N.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Univ Pittsburgh, Med Ctr, Mckeesport, PA USA..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Alam, Khurshid
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Queensland Hlth, Herston, Qld, Australia.;Univ Queensland, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldridge, Robert William
    UCL, Ctr Publ Hlth Data Sci, Inst Hlth Informat, London, England..
    Alegretti, Miguel Angel
    Univ Republica, Fac Med, Dept Prevent & Social Med, Montevideo, Uruguay..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Spanish Observ Drugs, Govt Delegat Natl Plan Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena De Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ameh, Emmanuel A.
    Natl Hosp, Abuja, Nigeria..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Assadi, Reza
    Atique, Suleman
    Avokpaho, Euripide Frinel G. Arthur
    Awasthi, Ashish
    Quintanilla, Beatriz Paulina Ayala
    Bacha, Umar
    Badawi, Alaa
    Univ Toronto, Dept Nutr Sci, Fac Med, Toronto, ON, Canada..
    Balakrishnan, Kalpana
    Banerjee, Amitava
    UCL, Farr Inst Hlth Informat Res, London, England..
    Banigbe, Bolanle F.
    Barac, Aleksandra
    Barber, Ryan M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Barker-Collo, Suzanne L.
    Barnighausen, Till
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Barrero, Lope H.
    Bayou, Tigist Assefa
    Mekelle Univ, Mekelle, Ethiopia..
    Bayou, Yibeltal Tebekaw
    Bazargan-Hejazi, Shahrzad
    Beardsley, Justin
    Bedi, Neeraj
    Bekele, Tolesa
    Bell, Michelle L.
    Bello, Aminu K.
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Berhane, Adugnaw
    Bernabe, Eduardo
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Bhatt, Samir
    Biadgilign, Sibhatu
    Bikbov, Boris
    Birlik, Sait Mentes
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Blore, Jed D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bourne, Rupert R. A.
    Brainin, Michael
    Brazinova, Alexandra
    Breitborde, Nicholas J. K.
    Brown, Alexandria
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Buckle, Geoffrey Colin
    Burch, Michael
    Butt, Zahid A.
    Campos-Nonato, Ismael Ricardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Cardenas, Rosario
    Carpenter, David
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Casey, Daniel C.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Castaneda-Oquela, Carlos A.
    Rivas, Jacqueline Castillo
    Castro, Ruben Estanislao
    Catala-Lopez, Ferran
    Cercy, Kelly
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Chang, Hsing-Yi
    Chang, Jung-Chen
    Chibueze, Chioma Ezinne
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christopher, Devasahayam Jesudas
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Colquhoun, Samantha M.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cornaby, Leslie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Damtew, Solomon Abrha
    Danawi, Hadi
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    das Neves, Jose
    Davis, Adrian C.
    de Jager, Pieter
    De Leo, Diego
    Degenhardt, Louisa
    Deribe, Kebede
    Deribew, Amare
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Jarlais, Don C. Des
    deVeber, Gabrielle A.
    Hosp Sick Children, Toronto, ON, Canada..
    Dharmaratne, Samath D.
    Dhillon, Preet K.
    Ding, Eric L.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Doshi, Pratik Pinal
    Doyle, Kerrie E.
    Duan, Leilei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Dubey, Manisha
    Ebrahimi, Hedyeh
    Ellingsen, Christian Lycke
    Elyazar, Iqbal
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Eshrati, Babak
    Esteghamati, Alireza
    Faraon, Emerito Jose Aquino
    Univ Philippines, Coll Publ Hlth, Manila, Philippines..
    Farid, Talha A.
    Farinha, Carla Sofia e Sa
    Faro, Andre
    Farvid, Maryam S.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Farzadfar, Farshad
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Joao C.
    Fischer, Florian
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Foigt, Nataliya
    Franklin, Richard C.
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Furst, Thomas
    Gambashidze, Ketevan
    Gamkrelidze, Amiran
    Ganguly, Parthasarathi
    Gebre, Teshome
    Gebrehiwot, Tsegaye Tewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia..
    Gebru, Alemseged Aregay
    Mekelle Univ, Mekelle, Ethiopia..
    Gelefinse, Johanna M.
    Gessner, Bradford D.
    Ginawi, Ibrahim Abdelmageem Mohamed
    Giref, Ababi Zergaw
    Gishu, Melkamu Dedefo
    Gomez-Dantes, Hector
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Goto, Atsushi
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Gugnani, Harish Chander
    Guo, Yuming
    Univ Queensland, Brisbane, Qld, Australia..
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Gyawali, Bishal
    Haagsma, Juanita A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Hafezi-Nejad, Nima
    Haile, Demewoz
    Hailu, Alemayehu Desalegne
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia..
    Hamadeh, Randah Ribhi
    Hancock, Jamie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Handal, Alexis J.
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Harun, Kimani M.
    Havmoeller, Rasmus
    Hay, Roderick J.
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hotez, Peter J.
    Hoy, Damian G.
    Hsairi, Mohamed
    Hu, Guoqing
    Huang, Cheng
    Huang, John J.
    Huang, Hsiang
    Huiart, Laetitia
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Innos, Kaire
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Guohong
    Jiang, Ying
    Jibat, Tariku
    Jin, Ye
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Jonas, Jost B.
    Kabir, Zubair
    Kalkonde, Yogeshwar
    Karnak, Ritul
    Kan, Haidong
    Kang, Gagandeep
    Karch, Andre
    Karema, Corine Kakizi
    Kasaeian, Amir
    Kaul, Anil
    Kawakami, Norito
    Univ Tokyo, Sch Publ Hlth, Tokyo, Japan..
    Kayibanda, Jeanne Francoise
    Kazanjan, Konstantin
    Keiyoro, Peter Njenga
    Kemp, Andrew Haddon
    Kengne, Andre Pascal
    Keren, Andre
    Kereselidze, Maia
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khalil, Ibrahim A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khang, Young -Ho
    Khonelidze, Irma
    Khubchandani, Jagdish
    Kim, Cho-il
    Kim, Daniel
    Kim, Yun Jin
    Kissoon, Niranjan
    Kivipelto, Miia
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Univ Queensland, Sch Publ Hlth, Herston, Qld, Australia..
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Koul, Parvaiz A.
    Koyanagi, Ai
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kyu, Hmwe H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia.;Univ Queensland, Sch Dent, Herston, Qld, Australia..
    Lam, Hilton
    Lam, Jennifer O.
    Lansingh, Van C.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    Li, Yichong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Li, Yongmei
    Lindsay, M. Patrice
    Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada..
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Liu, Shiwei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lo, Warren D.
    Logroscino, Giancarlo
    Low, Nicola
    Lunevicius, Raimundas
    Lyons, Ronan A.
    Ma, Stefan
    Abd El Razek, Hassan Magdy
    Abd El Razek, Mohammed Magdy
    Mandavi, Mandi
    Majdan, Marek
    Majeed, Azeem
    Malekzadeh, Reza
    Mapoma, Chabila C.
    Marcenes, Wagner
    -Raga, Jose Martinez
    Marzan, Melvin Barrientos
    Masiye, Felix
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    Meaney, Peter A.
    Mehari, Alem
    Mehndiratta, Man Mohan
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia..
    Melaku, Yohannes Adama
    Mekelle Univ, Sch Publ Hlth, Mekelle, Ethiopia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memiah, Peter
    Memish, Ziad A.
    Mendoza, Walter
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mhimbira, Francis Apolinary
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Mock, Charles N.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA 98195 USA..
    Mohammad, Karzan Abdulmuhsin
    Mohammadi, Alireza
    Mohammed, Shafiu
    Monasta, Lorenzo
    Montanez Hernandez, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    Moore, Ami R.
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich O.
    Murphy, Georgina A. V.
    Univ Oxford, Oxford, England..
    Murthy, Srinivas
    Nachega, Jean B.
    Naheed, Aliya
    Naidoo, Kovin S.
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Neupane, Subas
    Newton, Charles R.
    Newton, John N.
    Ng, Marie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Quyen Le
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Pete, Patrick Martial Nkamedjie
    Norheim, Ole F.
    Norman, Rosana E.
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Oren, Eyal
    Ota, Erika
    Mahesh, P. A.
    Park, Eun-Kee
    Park, Hye-Youn
    Parsaeian, Mahboubeh
    Caicedo, Angel J. Paternina
    Patten, Scott B.
    Pedro, Joao Mario
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Pillay, Julian David
    Pishgar, Farhad
    Polinder, Suzanne
    Pope, Daniel
    Popova, Svetlana
    Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada..
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rabiee, Rynaz H. S.
    Rafay, Anwar
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Ur Rahman, Mohammad Hifz
    Ur Rahman, Sajjad
    Rai, Rajesh Kumar
    Raju, Murugesan
    Ram, Usha
    Rana, Saleem M.
    Ranabhat, Chhabi Lal
    Rao, Puja
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Refaat, Amany H.
    Remuzzi, Giuseppe
    Resnikoff, Serge
    Reynolds, Alex
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Rojas-Rueda, David
    Ronfani, Luca
    Roshandel, Gholamreza
    Roth, Gregory A.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Roy, Ambuj
    Ruhago, George Mugambage
    Sagar, Rajesh
    Saleh, Muhammad Muhammad
    Sanabria, Juan R.
    Sanchez-Nino, Maria Dolores
    Santos, Itamar S.
    Santos, Joao Vasco
    Sarmiento-Suarez, Rodrigo
    Sartorius, Benn
    Satpathy, Maheswar
    Savic, Miloje
    Sawhney, Monika
    Schneider, Ione J. C.
    Schottker, Ben
    Schwebel, David C.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Seedat, Soraya
    Sepanlou, Sadaf G.
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Setegn, Tesfaye
    Bahir Dar Univ, Bahir Dar, Ethiopia..
    Shahraz, Saeid
    Shaikh, Masood Ali
    Shakh-Nazarova, Marina
    Sharma, Rajesh
    She, Jun
    Sheikhbahaei, Sara
    Shen, Jiabin
    Sheth, Kevin N.
    Shibuya, Kenji
    Univ Tokyo, Grad Sch Med, Dept Global Hlth Policy, Tokyo, Japan..
    Shin, Hwashin Hyun
    Shin, Min-Jeong
    Shiri, Rahman
    Shuie, Ivy
    Sigfusdottir, Inga Dora
    Silva, Diego Augusto Santos
    Silverberg, Jonathan
    Simard, Edgar P.
    Sindi, Shireen
    Singh, Abhishek
    Singh, Jasvinder A.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Singh, Om Prakash
    Singh, Prashant Kumar
    Singh, Virendra
    Soriano, Joan B.
    Soshnikov, Sergey
    Sposato, Luciano A.
    Sreeramareddy, Chandrashekhar T.
    Stathopoulou, Vasiliki
    Steel, Nicholas
    Stroumpoulis, Konstantinos
    Sturua, Lela
    Sunguya, Bruno F.
    Swaminathan, Soumya
    Sykes, Bryan L.
    Szoeke, Cassandra E. I.
    Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Tavakkoli, Mohammad
    Taye, Bineyam
    Tedla, Bemnet Amare
    Tefera, Worku Mekonnen
    Tekle, Tesfaye
    Mekelle Univ, Mekelle, Ethiopia..
    Shifa, Girma Temam
    Terkawi, Abdullah Sulieman
    Tesfay, Fisaha Haile
    Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia..
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia..
    Thapa, Kiran
    Thomson, Alan J.
    -Lyman, Andrew L. Thorne
    Harvard Univ, Dept Nutr, Boston, MA 02115 USA..
    Tobe-Gai, Ruoyan
    Tonelli, Marcello
    Topor-Madry, Roman
    Topouzis, Fotis
    Tran, Bach Xuan
    Troeger, Christopher
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Truelsen, Thomas
    Dimbuene, Zacharie Tsala
    Tura, Abera Kenay
    Tyrovolas, Stefanos
    Ukwaja, Kingsley N.
    Uneke, Chigozie Jesse
    Uthman, Olalekan A.
    Vaezghasemi, Masoud
    Vasankari, Tommi
    Vasconcelos, Ana Maria Nogales
    Venketasubramanian, Narayanaswamy
    Verma, Raj Kumar
    Violante, Francesco S.
    Vladimirov, Sergey K.
    Vlassov, Vasiliy Victorovich
    Vollset, Stein Emil
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Linhong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Wang, Yanping
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Weiss, Daniel J.
    Univ Oxford, Oxford, England..
    Werdecker, Andrea
    Westerman, Ronny
    Widdowson, Marc -Alain
    Wijeratne, Tissa
    Univ Melbourne, Melbourne, Vic, Australia..
    Williams, Thomas Neil
    Wiysonge, Charles Shey
    Wolfe, Charles D. A.
    Wolfe, Ingrid
    Won, Sungho
    Wubshet, Mamo
    Xiao, Qingyang
    Xu, Gelin
    Yadav, Ajit Kumar
    Yakob, Bereket
    Yano, Yuichiro
    Yaseri, Mehdi
    Ye, Pengpeng
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Yebyo, Henock Gebremedhin
    Mekelle Univ, Mekelle, Ethiopia..
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z.
    Yu, Chuanhua
    Zaidi, Zoubida
    Zaki, Maysaa El Sayed
    Zeeb, Hajo
    Zhang, Hao
    Zhao, Yong
    Zheng, Yingfeng
    Zhou, Maigeng
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Zodpey, Sanjay
    Murray, Christopher J. L.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, 1725-1774 p.Article in journal (Refereed)
    Abstract [en]

    Background Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. Methods Drawing from analytical approaches developed and refined in previous iterations of the GBD study, we generated updated estimates of child mortality by age group (neonatal, post-neonatal, ages 1-4 years, and under 5) for 195 countries and territories and selected subnational geographies, from 1980-2015. We also estimated numbers and rates of stillbirths for these geographies and years. Gaussian process regression with data source adjustments for sampling and non-sampling bias was applied to synthesise input data for under-5 mortality for each geography. Age-specific mortality estimates were generated through a two-stage age-sex splitting process, and stillbirth estimates were produced with a mixed-effects model, which accounted for variable stillbirth definitions and data source-specific biases. For GBD 2015, we did a series of novel analyses to systematically quantify the drivers of trends in child mortality across geographies. First, we assessed observed and expected levels and annualised rates of decrease for under-5 mortality and stillbirths as they related to the Soci-demographic Index (SDI). Second, we examined the ratio of recorded and expected levels of child mortality, on the basis of SDI, across geographies, as well as differences in recorded and expected annualised rates of change for under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality to changes in SDI at the global level, as well as changes in leading causes of under-5 deaths for countries and territories. We documented each step of the GBD 2015 child mortality estimation process, as well as data sources, in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, 5.8 million (95% uncertainty interval [UI] 5.7-6.0) children younger than 5 years died in 2015, representing a 52.0% (95% UI 50.7-53.3) decrease in the number of under-5 deaths since 1990. Neonatal deaths and stillbirths fell at a slower pace since 1990, decreasing by 42.4% (41.3-43.6) to 2.6 million (2.6-2.7) neonatal deaths and 47.0% (35.1-57.0) to 2.1 million (1.8-2.5) stillbirths in 2015. Between 1990 and 2015, global under-5 mortality decreased at an annualised rate of decrease of 3.0% (2.6-3.3), falling short of the 4.4% annualised rate of decrease required to achieve MDG4. During this time, 58 countries met or exceeded the pace of progress required to meet MDG4. Between 2000, the year MDG4 was formally enacted, and 2015, 28 additional countries that did not achieve the 4.4% rate of decrease from 1990 met the MDG4 pace of decrease. However, absolute levels of under-5 mortality remained high in many countries, with 11 countries still recording rates exceeding 100 per 1000 livebirths in 2015. Marked decreases in under-5 deaths due to a number of communicable diseases, including lower respiratory infections, diarrhoeal diseases, measles, and malaria, accounted for much of the progress in lowering overall under-5 mortality in low-income countries. Compared with gains achieved for infectious diseases and nutritional deficiencies, the persisting toll of neonatal conditions and congenital anomalies on child survival became evident, especially in low-income and low-middle-income countries. We found sizeable heterogeneities in comparing observed and expected rates of under-5 mortality, as well as differences in observed and expected rates of change for under-5 mortality. At the global level, we recorded a divergence in observed and expected levels of under-5 mortality starting in 2000, with the observed trend falling much faster than what was expected based on SDI through 2015. Between 2000 and 2015, the world recorded 10.3 million fewer under-5 deaths than expected on the basis of improving SDI alone. Interpretation Gains in child survival have been large, widespread, and in many places in the world, faster than what was anticipated based on improving levels of development. Yet some countries, particularly in sub-Saharan Africa, still had high rates of under-5 mortality in 2015. Unless these countries are able to accelerate reductions in child deaths at an extraordinary pace, their achievement of proposed SDG targets is unlikely. Improving the evidence base on drivers that might hasten the pace of progress for child survival, ranging from cost-effective intervention packages to innovative financing mechanisms, is vital to charting the pathways for ultimately ending preventable child deaths by 2030.

  • Broomé, Ludvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Broomé, Ludvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Den auktoritära dynamiken i SD:s väljarbas: Ett socialpsykologiskt perspektiv på svensk politik2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study tests Karen Stenner's theory of "The Authoritarian Dynamic" on voters of Swedish populist radical right party. It finds that the theory is highly applicable in the Swedish context; authoritarian voters turn out in large numbers for the Sweden Democrats. Voters with an authoritarian predisposition, meaning they value order and hierarchy in society, have to a large extent become activated in Sweden, rendering intolerant and aggressive behaviour. For authoritarians with low trust in the Swedish parliament this effect was particularly evident. Furthermore, the study finds that religious voters are far less likely to vote for the radical right. Lastly, an investigation into free time organisational activities of the Swedes is conducted. The result of this last study is that voters who are not active in any kind of organisation (sport clubs, choirs, religious communities) are more receptive to the message of the Sweden Democrats. The author's theory, with reference to the aforementioned, holds that a lacking sense of belonging and purpose are key factors driving support for the Sweden Democrats. This is particularly true for the authoritarian voters, who are often more prone to think in collective identities rather than in individual ones. The study attempts to fuse the political psychological theories of Karen Stenner with Robert Putnam's theory of social trust. Based on data from World Values Survey it finds robust statistical evidence for this connection. 

  • Johsefin, Tallroth
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Johsefin, Tallroth
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The ripple effects of discourses: An examination of post-colonial tendencies among three British NGOs2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Skytt, Therese
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Skytt, Therese
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    "EU - hot eller möjlighet?": En studie om hur EU:s politiska system förmedlas i undervisning.2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Lim, Stephen S.
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Lim, Stephen S.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Allen, Kate
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bhutta, Zulficiar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Forouzanfar, Mohammad H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Fullman, Nancy
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Goldberg, Ellen M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Holmberg, Mollie
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Kutz, Michael J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    McNellan, Claire R.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Naghavi, Mohsen
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Olsen, Helen E.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Pigott, David M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Salomon, Joshua A.
    Harvard Univ, Dept Global Hlth & Populat, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Abajobir, Amanuel Alemu
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbafati, Cristiana
    Univ Roma La Sapienza, Rome, Italy..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abdulle, Abdishakur M.
    New York Univ Abu Dhabi, Abu Dhabi, U Arab Emirates..
    Abraham, Biju
    NMSM Govt Coll Kalpetta, Kalpetta, Kerala, India..
    Abubakar, Ibrahim
    UCL, Inst Global Hlth, London, England..
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar..
    Abu-Rmeileh, Niveen M. E.
    Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Abyu, Gebre Yitayih
    Mekelle Univ, Mekelle, Ethiopia..
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Afshin, Ashkan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Agarwal, Arnav
    McMaster Univ, Hamilton, ON, Canada..
    Agrawal, Anurag
    CSIR Inst Genom & Integrat Biol, Delhi, India.;Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA..
    Kiadaliri, Aliasghar Ahmad
    Ahmadieh, Hamid
    Ahmed, Kedir Yimam
    Debre Markos Univ, Debre Markos, Ethiopia..
    Akanda, Ali Shafqat
    Univ Rhode Isl, Kingston, RI 02881 USA..
    Akinyemi, Rufus Olusola
    Univ Ibadan, Ibadan, Nigeria.;Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England..
    Akinyemiju, Tomi F.
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Alam, Uzma
    Int Ctr Humanitarian Affairs, Nairobi, Kenya..
    Alasfoor, Deena
    AlBuhairan, Fadia S.
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia..
    Dge, Robert William Aldr.
    UCL, Inst Global Hlth, London, England.;UCL, Ctr Publ Hlth Data Sci, Inst Hlth Informat, London, England.;UCL, Farr Inst Hlth Informat Res, London, England..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alkhateeb, Mohammad A. B.
    King Saud Univ, King Khalid Univ Hosp, Riyadh, Saudi Arabia..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Allebeck, Peter
    Allen, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Govt Madrid, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Amini, Heresh
    Kurdistan Univ Med Sci, Environm Hlth Res Ctr, Sanandaj, Iran.;Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland..
    Ammar, Walid
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Benjamin O.
    Univ Washington, Seattle, WA 98121 USA..
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Antonio, Carl Abelardo T.
    Univ Philippines Manila, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Artaman, Al
    Univ Manitoba, Winnipeg, MB, Canada..
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;LERAS Afrique, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    La Trobe Univ, Judith Lumley Ctr Mother Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.;Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia.;Burnet Inst, Ctr Int Hlth, Melbourne, Vic, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Dept Environm Hlth Engn, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    UCL, Farr Inst Hlth Informat Res, London, England..
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barber, Ryan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Barrero, Lope H.
    Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia..
    Barrientos-Gutierrez, Tonatiuh
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Mekelle Univ, Mekelle, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, Coll Med, 1621 E 120th St, Los Angeles, CA 90059 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, Neeraj
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Beghi, Ettore
    IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy..
    Bejot, Yannick
    Univ Burgundy, Univ Hosp & Med Sch Dijon, Dijon, France..
    Bell, Michelle L.
    Yale Univ, Sch Med, New Haven, CT USA..
    Bello, Aminu K.
    Univ Alberta, Edmonton, AB, Canada..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Benzian, Habib
    UCL, Dept Epidemiol & Publ Hlth, London, England.;NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USA..
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Kings Coll London, London, England..
    Bernal, Oscar Alberto
    Univ Andes, Bogota, Colombia. Haramaya Univ, Coll Hlth & Med Sci, Harar, Ethiopia..
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Bhala, Neeraj
    Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England.;Univ Otago, Sch Med, Wellington, New Zealand..
    Bhatt, Samir
    Imperial Coll, London, England..
    Biadgilign, Sibhatu
    Bienhoff, Kelly A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bikbov, Boris
    Academician VI Shumakov Fed Res Ctr Transplantol, Issues Transplanted Kidney, Dept Nephrol, Moscow, Russia..
    Binagwaho, Agnes
    Harvard Univ, Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA.;Dartmouth Coll, Dept Pediat, Hanover, NH 03755 USA.;Dartmouth Coll, Dartmouth Inst Hlth Policy & Clin Practice, Geisel Sch Med, Hanover, NH 03755 USA.;Univ Global Hlth Equ, Kigali, Rwanda..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Univ Oslo, Dept Community Med, Oslo, Norway..
    Blore, Jed
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Bourne, Rupert R. A.
    Anglia Ruskin Univ, Vis Eye Res Unit, Cambridge, England..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brauer, Michael
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ British Columbia, Vancouver, BC, Canada..
    Brazinova, Alexandra
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia.;Int Neurotrauma Res Org, Vienna, Austria..
    Breitborde, Nicholas J. K.
    Ohio State Univ, Coll Med, Columbus, OH 43210 USA..
    Broday, David M.
    Technion, Haifa, Israel..
    Brugha, Traolach S.
    Univ Leicester, Leicester, Leics, England..
    Buchbinder, Rachelle
    Cabrini Inst, Monash Dept Clin Epidemiol, Melbourne, Vic, Australia.;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia..
    Butt, Zahid A.
    Al Shifa Trust Eye Hosp, Rawalpindi, Pakistan..
    Cahill, Leah E.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.;Dalhousie Univ, Halifax, NS, Canada..
    Campos-Nonato, Ismael Ricardo
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Carabin, Helene
    Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA..
    Cardenas, Rosario
    Metropolitan Autonomous Univ, Mexico City, DF, Mexico..
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Casey, Daniel
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Caso, Valeria
    Univ Perugia, Stroke Unit, Perugia, Italy..
    Castaneda-Orjuela, Carlos A.
    Inst Nacl Salud, Colombian Natl Hlth Observ, Bogota, Colombia.;Univ Nacl Colombia, Dept Publ Hlth, Epidemiol & Publ Hlth Evaluat Grp, Bogota, Colombia..
    Rivas, Jacqueline Castillo
    Caja Costarricense Seguro Social, San Jose, Costa Rica.;Univ Costa Rica, San Pedro, Montes De Oca, Costa Rica..
    Catala-Lopez, Ferran
    Cavalleri, Fiorella
    Cecilio, Pedro
    Chang, Hsing-Yi
    Chang, Jung-Chen
    Charlson, Fiona J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Che, Xuan
    Chen, Alan Zian
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Chiang, Peggy Pei-Chia
    Chibalabala, Mirriam
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christensen, Hanne
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Cohen, Aaron J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Cooke, Graham S.
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cooper, Leslie Trumbull
    Cowie, Benjamin C.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia..
    Crump, John A.
    Damtew, Solomon Abrha
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Dargan, Paul I.
    das Neves, Jose
    Davis, Adrian C.
    Davletov, Kairat
    de Castro, E. Filipa
    De Leo, Diego
    Degenhardt, Louisa
    Del Gobbo, Liana C.
    Stanford Univ, Stanford, CA 94305 USA..
    Deribe, Kebede
    Derrett, Sarah
    Jarlais, Don C. Des
    Deshpande, Aniruddha
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    deVeber, Gabrielle A.
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dey, Subhojit
    Dharmaratne, Samath D.
    Dhillon, Preet K.
    Ding, Eric L.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Dorsey, E. Ray
    Doyle, Kerrie E.
    Driscoll, Tim R.
    Duan, Leilei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Dubey, Manisha
    Duncan, Bruce Bartholow
    Ebrahimi, Hedyeh
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Erskine, Holly E.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Eshrati, Babak
    Esteghamati, Alireza
    Fahimi, Saman
    Farid, Talha A.
    Farinha, Carla Sofia e Sa
    Faro, Andre
    Farvid, Maryam S.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Farzadfar, Farshad
    Feigin, Valery L.
    Felicio, Manuela Mendonca
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Jefferson G.
    Fernandes, Joao C.
    Ferrari, Alize J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Fischer, Florian
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Fitzmaurice, Christina
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Foigt, Nataliya
    Foreman, Kyle
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Fowkes, F. Gerry R.
    Franca, Elisabeth Barboza
    Franklin, Richard C.
    Fraser, Maya
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Frostad, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Furst, Thomas
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland..
    Gabbe, Belinda
    Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia..
    Garcia-Basteiro, Alberto L.
    Gebre, Teshome
    Gebrehiwot, Tsegaye Tewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia..
    Gebru, Alemseged Aregay
    Mekelle Univ, Mekelle, Ethiopia..
    Gessner, Bradford D.
    Gillum, Richard F.
    Ginawi, Ibrahim Abdelmageem Mohamed
    Giref, Ababi Zergaw
    Giroud, Maurice
    Gishu, Melkamu Dedefo
    Godwin, William
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Gotay, Carolyn C.
    Univ British Columbia, Vancouver, BC, Canada..
    Goto, Atsushi
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Graetz, Nicholas
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Greenwell, Karen Fern
    Griswold, Max
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Guo, Yuming
    Univ Queensland, Brisbane, Qld, Australia..
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Gutierrez, Reyna A.
    Gyawali, Bishal
    Haagsma, Juanita A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Haakenstad, Annie
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Hafezi-Nejad, Nima
    Haile, Demewoz
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia..
    Halasa, Yara A.
    Hamadeh, Randah Ribhi
    Hamidi, Samer
    Hammami, Mouhanad
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Haro, Josep Maria
    Hassanvand, Mohammad Sadegh
    Havmoeller, Rasmus
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hoy, Damian G.
    Htet, Aung Soe
    Univ Oslo, Oslo, Norway..
    Hu, Guoqing
    Huang, Hsiang
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Inoue, Manami
    Islami, Farhad
    Jacobs, Troy A.
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Jakovljevic, Mihajlo B.
    James, Peter
    Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Channing Div Network Med, Brigham & Womens Hosp, Harvard Med Sch, Boston, MA 02115 USA..
    Jansen, Henrica A. F. M.
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Ying
    Jibat, Tariku
    Jin, Ye
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Jonas, Jost B.
    Kabir, Zubair
    Kalkonde, Yogeshwar
    Kamal, Ritul
    Kan, Haidong
    Kandel, Amit
    Karch, Andre
    Karema, Corine Kakizi
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland..
    KarimIchani, Chante
    Karunapema, Palitha
    Kasaeian, Amir
    Kassebaum, Nicholas J.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kaul, Anil
    Kawakami, Norito
    Kayibanda, Jeanne Francoise
    Keiyoro, Peter Njenga
    Kemmer, Laura
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kemp, Andrew Haddon
    Kengne, Andre Pascal
    Keren, Andre
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khan, Gulfaraz
    Khang, Young-Ho
    Khoja, Tawfik Ahmed Muthafer
    Khosravi, Ardeshir
    Khubchandani, Jagdish
    Kieling, Christian
    Kim, Cho-il
    Kim, Daniel
    Kim, Sungroul
    Kim, Yun Jin
    Kimokoti, Ruth W.
    Kissoon, Niranjan
    Univ British Columbia, Vancouver, BC, Canada..
    Kivipelto, Miia
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Kokubo, Yoshihiro
    Kolte, Dhaval
    Kosen, Soewarta
    Kotsakis, Georgios A.
    Univ Washington, Sch Dent, Seattle, WA 98121 USA..
    Koul, Parvaiz A.
    Koyanagi, Ai
    Kravchenko, Michael
    Krueger, Hans
    Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada..
    Defo, Barthelemy Kuate
    Kuchenbecker, Ricardo S.
    Kuipers, Ernst J.
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Kulkarni, Veena S.
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kwan, Gene F.
    Kyu, Hmwe H.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Lal, Aparna
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia..
    Lam, Hilton
    Lan, Qing
    Langan, Sinead M.
    London Sch Hyg & Trop Med, London, England..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Laryea, Dennis Odai
    Latif, Asma Abdul
    Leasher, Janet L.
    Leigh, James
    Leinsalu, Mall
    Leung, Janni
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Leung, Ricky
    Levi, Miriam
    Li, Yichong
    Li, Yongmei
    Lind, Margaret
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Linn, Shai
    Lipshultz, Steven E.
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Liu, Shiwei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Liu, Yang
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lo, Loon-Tzian
    Logroscino, Giancarlo
    Lotufo, Paulo A.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Lucas, Robyn M.
    Lunevicius, Raimundas
    Abd El Razek, Mohammed Magdy
    Magis-Rodriguez, Carlos
    Mandavi, Mandi
    Majdan, Marek
    Trnava Univ, Dept Publ Hlth, Fac Hlth Sci & Social Work, Trnava, Slovakia..
    Majeed, Azeem
    Malekzadeh, Reza
    Malta, Deborah Carvalho
    Mapoma, Chabila C.
    Margolis, David Joel
    Martin, Randall V.
    Dalhousie Univ, Halifax, NS, Canada..
    Martinez-Raga, Jose
    Masiye, Felix
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mason-Jones, Amanda J.
    Massano, Joao
    Matzopoulos, Richard
    Mayosi, Bongani M.
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    McKee, Martin
    London Sch Hyg & Trop Med, London, England..
    Meaney, Peter A.
    Mehari, Alem
    Mekonnen, Alemayehu B.
    Melaku, Yohannes Adama
    Mekelle Univ, Sch Publ Hlth, Mekelle, Ethiopia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memiah, Peter
    Memish, Ziad A.
    Mendoza, Walter
    Mensink, Gert B. M.
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mesfin, Yonatan Moges
    Haramaya Univ, Harar, Ethiopia..
    Mhimbira, Francis Apolinary
    Micha, Renata
    Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA..
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Mitchell, Philip B.
    Mock, Charles N.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA 98121 USA..
    Mohammadi, Alireza
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Monasta, Lorenzo
    Monis, Jonathan de la Cruz
    Hernandez, Julio Cesar Montanez
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich O.
    Murdoch, Michele E.
    Murimira, Brighton
    Murray, Joseph
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg & Trop Med, London, England..
    Murthy, Srinivas
    Univ British Columbia, Vancouver, BC, Canada..
    Musa, Kamarul Imran
    Nachega, Jean B.
    Nagel, Gabriele
    Naidoo, Kovin S.
    Naldi, Luigi
    Nangia, Vinay
    Neal, Bruce
    Nejjari, Chakib
    Newton, Charles R.
    Newton, John N.
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Nguyen, Quyen Le
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Pete, Patrick Martial Nkamedjie
    Nolte, Sandra
    Nomura, Marika
    Norheim, Ole F.
    Norrving, Bo
    Obermeyer, Carla Makhlouf
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Oladimeji, Olanrewaju
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Opio, John Nelson
    Oren, Eyal
    Ortiz, Alberto
    Osborne, Richard H.
    Ota, Erika
    Owolabi, Mayowa O.
    Univ Ibadan, Dept Med, Ibadan, Nigeria..
    Mahesh, P. A.
    Park, Eun-Kee
    Park, Hye-Youn
    Parry, Charles D.
    Parsaeian, Mahboubeh
    Patel, Tejas
    Patel, Vikram
    London Sch Hyg & Trop Med, Ctr Global Mental Hlth, London, England..
    Caicedo, Angel J. Paternina
    Univ Cartagena, Cartagena, Colombia..
    Patil, Snehal T.
    Patten, Scott B.
    Patton, George C.
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia..
    Paudel, Deepak
    Pedro, Joao Mario
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Piel, Frederic B.
    Pillay, Julian David
    Pinho, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Pishgar, Farhad
    Polinder, Suzanne
    Poulton, Richie G.
    Pourmalek, Farshad
    Univ British Columbia, Vancouver, BC, Canada..
    Qorbani, Mostafa
    Rabiee, Rynaz H. S.
    Radfar, Amir
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Rajsic, Sasa
    Raju, Murugesan
    Ram, Usha
    Rana, Saleem M.
    Ranabhat, Chhabi Lal
    Ranganathan, Kavitha
    Rao, Puja C.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Refaat, Amany H.
    Reitsma, Marissa B.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Remuzzi, Giuseppe
    Resnikoff, Serge
    Ribeiro, Antonio L.
    Blancas, Maria Jesus Rios
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Rolm, Hirbo Shore
    Roberts, Bayard
    London Sch Hyg & Trop Med, London, England..
    Rodriguez, Mina
    Rojas-Rueda, David
    Ronfani, Luca
    Roshandel, Gholamreza
    Roth, Gregory A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Rothenbacher, Dietrich
    Roy, Ambuj
    Roy, Nobhojit
    Sackey, Ben Benasco
    Sagar, Rajesh
    Saleh, Muhammad Muhammad
    Sanabria, Juan R.
    Santomauro, Damian F.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Santos, Itamar S.
    Univ Sao Paulo, Dept Internal Med, Sao Paulo, Brazil..
    Sarmiento-Suarez, Rodrigo
    Sartorius, Benn
    Satpathy, Maheswar
    Savic, Miloje
    Sawhney, Monika
    Sawyer, Susan M.
    Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia..
    Schmidhuber, Josef
    Schmidt, Maria Ines
    Schneider, Ione J. C.
    Schutte, Aletta E.
    Schwebel, David C.
    Seedat, Soraya
    Sepanlou, Sadaf G.
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Shackelford, Katya
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Shaheen, Amira
    Shaikh, Masood Ali
    Levy, Teresa Shamah
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Sharma, Rajesh
    She, Jun
    Sheikhbahaei, Sara
    Shen, Jiabin
    Sheth, Kevin N.
    Shey, Muki
    Shi, Peilin
    Tufts Univ, Boston, MA 02111 USA..
    Shibuya, Kenji
    Shigematsu, Mika
    Shin, Min-Jeong
    Shiri, Rahman
    Shishani, Kawkab
    Shiue, Ivy
    Sigfusdottir, Inga Dora
    Silpakit, Naris
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Silva, Diego Augusto Santos
    Silverberg, Jonathan I.
    Simard, Edgar P.
    Sindi, Shireen
    Singh, Abhishek
    Singh, Gitanjali M.
    Tufts Univ, Boston, MA 02111 USA..
    Singh, Jasvinder A.
    Singh, Om Prakash
    Singh, Prashant Kumar
    Skirbekk, Vegard
    Sligar, Amber
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Soneji, Samir
    Dartmouth Coll, Hanover, NH 03755 USA..
    Soreide, Kjetil
    Sorensen, Reed J. D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Soriano, Joan B.
    Soshnikov, Sergey
    Sposato, Luciano A.
    Sreeramareddy, Chandrashekhar T.
    Stahl, Hans-Christian
    Stanaway, Jeffrey D.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Stathopoulou, Vasiliki
    Steckling, Nadine
    Steel, Nicholas
    Stein, Dan J.
    Steiner, Caitlyn
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Stockl, Heidi
    London Sch Hyg & Trop Med, London, England..
    Stranges, Saverio
    Strong, Mark
    Sun, Jiandong
    Sunguya, Bruno F.
    Sur, Patrick
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Swaminathan, Soumya
    Sykes, Bryan L.
    Szoeke, Cassandra E. I.
    Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Tabb, Karen M.
    Talongwa, Roberto Tchio
    Tarawneh, Mohammed Rasoul
    Tavakkoli, Mohammad
    Taye, Bineyam
    Taylor, Hugh R.
    Univ Melbourne, Melbourne, Vic, Australia..
    Tedla, Bemnet Amare
    Tefera, Worku
    Tegegne, Teketo Kassaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Tekle, Dejen Yemane
    Mekelle Univ, Mekelle, Ethiopia..
    Shifa, Girma Temam
    Terkawi, Abdullah Sulieman
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia..
    Thakur, J. S.
    Thomson, Alan J.
    Thorne-Lyman, Andrew L.
    Harvard Univ, Dept Nutr, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Thrift, Amanda G.
    Monash Univ, Dept Med, Sch Clin Sci, Monash Hlth, Melbourne, Vic, Australia..
    Thurston, George D.
    Tillmann, Taavi
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Tobe-Gai, Ruoyan
    Tonelli, Marcelo
    Topor-Madry, Roman
    Topouzis, Fotis
    Tran, Bach Xuan
    Dimbuene, Zacharie Tsala
    Tura, Abera Kenay
    Tuzcu, Emin Murat
    Tyrovolas, Stefanos
    Ukwaja, Kingsley Nnanna
    Undurraga, Eduardo A.
    Uneke, Chigozie Jesse
    Uthman, Olalekan A.
    van Donkelaar, Aaron
    Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada..
    Varakin, Yuri Y.
    Vasankari, Tommi
    Vasconcelos, Ana Maria Nogales
    Veerman, J. Lennert
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Venketasubramanian, Narayanaswamy
    Verma, Raj Kumar
    Violante, Francesco S.
    Vlassov, Vasiliy Victorovich
    Volkow, Patricia
    Vollset, Stein Emil
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Wagner, Gregory R.
    Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Wallin, Mitchell T.
    Wang, Linhong
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Wanga, Valentine
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Watkins, David A.
    Univ Washington, Seattle, WA 98121 USA..
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G.
    Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Weiss, Daniel J.
    Univ Oxford, Oxford, England..
    Werdecker, Andrea
    Westerman, Ronny
    Whiteford, Harvey A.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Wilkinson, James D.
    Wiysonge, Charles Shey
    Wolfe, Charles D. A.
    Kings Coll London, Div Hlth & Social Care Res, London, England..
    Wolfe, Ingrid
    Kings Coll London, London, England..
    Won, Sungho
    Woolf, Anthony D.
    Workie, Shimelash Bitew
    Wubshet, Mamo
    Xu, Gelin
    Yadav, Ajit Kumar
    Yakob, Bereket
    Yalew, Ayalnesh Zemene
    Mekelle Univ, Mekelle, Ethiopia..
    Yan, Lijing L.
    Yano, Yuichiro
    Yaseri, Mehdi
    Ye, Pengpeng
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Yip, Paul
    Univ Hong Kong, Social Work & Social Adm Dept, Hong Kong, Hong Kong, Peoples R China.;Univ Hong Kong, Hong Kong Jockey Club Ctr Suicide Res & Prevent, Hong Kong, Hong Kong, Peoples R China..
    Yonemoto, Naohiro
    Kyoto Univ, Sch Publ Hlth, Dept Biostat, Kyoto, Japan..
    Yoon, Seok-Jun
    Younis, Mustafa Z.
    Jackson State Univ, Jackson, MS USA..
    Yu, Chuanhua
    Zaidi, Zoubida
    Zaki, Maysaa El Sayed
    Zambrana-Torrelio, Carlos
    Zapata, Tomas
    Zegeye, Elias Asfaw
    Ethiopian Publ Hlth Inst, Addis Ababa, Ethiopia..
    Zhao, Yi
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Zhou, Maigeng
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.;Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Zodpey, Sanjay
    Zonies, David
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Murray, Christopher J. L.
    Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA..
    Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, 1813-1850 p.Article in journal (Refereed)
    Abstract [en]

    Background In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015). Methods We applied statistical methods to systematically compiled data to estimate the performance of 33 health-related SDG indicators for 188 countries from 1990 to 2015. We rescaled each indicator on a scale from 0 (worst observed value between 1990 and 2015) to 100 (best observed). Indices representing all 33 health-related SDG indicators (health-related SDG index), health-related SDG indicators included in the Millennium Development Goals (MDG index), and health-related indicators not included in the MDGs (non-MDG index) were computed as the geometric mean of the rescaled indicators by SDG target. We used spline regressions to examine the relations between the Socio-demographic Index (SDI, a summary measure based on average income per person, educational attainment, and total fertility rate) and each of the health-related SDG indicators and indices. Findings In 2015, the median health-related SDG index was 59.3 (95% uncertainty interval 56.8-61.8) and varied widely by country, ranging from 85.5 (84.2-86.5) in Iceland to 20.4 (15.4-24.9) in Central African Republic. SDI was a good predictor of the health-related SDG index (r(2) = 0.88) and the MDG index (r(2) = 0.2), whereas the non-MDG index had a weaker relation with SDI (r(2) = 0.79). Between 2000 and 2015, the health-related SDG index improved by a median of 7.9 (IQR 5.0-10.4), and gains on the MDG index (a median change of 10.0 [6.7-13.1]) exceeded that of the non-MDG index (a median change of 5.5 [2.1-8.9]). Since 2000, pronounced progress occurred for indicators such as met need with modern contraception, under-5 mortality, and neonatal mortality, as well as the indicator for universal health coverage tracer interventions. Moderate improvements were found for indicators such as HIV and tuberculosis incidence, minimal changes for hepatitis B incidence took place, and childhood overweight considerably worsened. Interpretation GBD provides an independent, comparable avenue for monitoring progress towards the health-related SDGs. Our analysis not only highlights the importance of income, education, and fertility as drivers of health improvement but also emphasises that investments in these areas alone will not be sufficient. Although considerable progress on the health-related MDG indicators has been made, these gains will need to be sustained and, in many cases, accelerated to achieve the ambitious SDG targets. The minimal improvement in or worsening of health-related indicators beyond the MDGs highlight the need for additional resources to effectively address the expanded scope of the health-related SDGs.

  • Kassebaum, Nicholas J.
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    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kassebaum, Nicholas J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Barber, Ryan M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bhutta, Zulfiqar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lim, Stephen S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Mensah, George A.
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Naghavi, Mohsen
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pinho, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Salomon, Joshua A.
    Steiner, Caitlyn
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Abajobir, Amanuel Alemu
    Abate, Kalkidan Hassen
    Abbas, Kaja M.
    Abd-Allah, Foad
    Abdallat, Mahmud A.
    Abdulle, Abdishakur M.
    Abera, Semaw Ferede
    Aboyans, Victor
    Abubakar, Ibrahim
    Abu-Rmeileh, Niveen M. E.
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adelekan, Ademola Lukman
    Univ Ibadan, Ibadan, Nigeria.;Publ Hlth Promot Alliance, Osogbo, Nigeria..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Kiadaliri, Aliasghar Ahmad
    Lund Univ, Clin Epidemiol Unit, Orthoped, Dept Clin Sci Lund, Lund, Sweden.;Kerman Univ Med Sci, Inst Futures Studies Hlth, Hlth Serv Management Res Ctr, Kerman, Iran..
    Ajala, Oluremi N.
    Univ Pittsburgh, Med Ctr, Mckeesport, PA USA..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA. Univ Alabama Birmingham, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Queensland Hlth, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia. King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia.;King Fahad Med City, Riyadh, Saudi Arabia..
    Aldridge, Robert William
    Alhabib, Samia
    King Abdullah Bin Abdulaziz Univ Hosp, Riyadh, Saudi Arabia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Govt Delegat Natl Plan Drugs, Spanish Observ Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena De Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia. Bahir Dar Univ, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Antoine, Rose Mayerline
    Rose Fdn Haiti, Portau Au Prince, Haiti..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Aregay, Atsede Fantahun
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Arora, Megha
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Arsenijevic, Valentina S. Arsic
    Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade, Serbia.;Univ Childrens Hosp, Belgrade, Serbia..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;LERAS Afrique, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgraduate Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    La Trobe Univ, Judith Lumley Ctr Mother Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.;Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada.;Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Bahit, Maria C.
    INECO Neurociencias, Rosario, Santa Fe, Argentina..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Bayou, Yibeltal Tebekaw
    Jhpiego Ethiopia, Addis Ababa, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, 1621 E 120th St, Los Angeles, CA 90059 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, NeerajHaidong Wang
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Bekele, Tolesa
    Madawalabu Univ, Bale Goba, Ethiopia..
    Bell, Michelle L.
    Yale Univ, New Haven, CT USA..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Betsu, Balem Demtsu
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Biadgilign, Sibhatu
    Bikbov, Boris
    Academician VI Shumakov Fed Res Ctr Transplantol, Dept Nephrol Issues Transplanted Kidney, Moscow, Russia..
    Bin Abdulhak, Aref A.
    Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA..
    Biroscak, Brian J.
    Yale Univ, New Haven, CT USA.;Univ S Florida, Tampa, FL USA..
    Biryukov, Stan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Blore, Jed D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brazinova, Alexandra
    Breitborde, Nicholas J. K.
    Brugha, Traolach S.
    Butt, Zahid A.
    Campos-Nonato, Ismael Ricardo
    Campuzano, Julio Cesar
    Cardenas, Rosario
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Casey, Daniel C.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Castaneda-Oquela, Carlos A.
    Castro, Ruben Estanislao
    Catala-Lopez, Ferran
    Cavalleri, Fiorella
    Chang, Hsing-Yi
    Chang, Jung -Chen
    Chavan, Laxmikant
    Chibueze, Chioma Ezinne
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christopher, Devasahayam Jesudas
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Colistro, Valentina
    Colquhoun, Samantha M.
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cooper, Leslie Trumbull
    Cortinovis, Monica
    Dahiru, Tukur
    Damasceno, Albertino
    Danawi, Hadi
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Das Neves, Jose
    De Leo, Diego
    Dellavalle, Robert P.
    Deribe, Kebede
    Deribew, Amare
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Jarlais, Don C. Des
    Dharmaratne, Samath D.
    Dicker, Daniel J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ding, Eric L.
    Dossou, Edem
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Dubey, Manisha
    Ebel, Beth E.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA USA..
    Ellingsen, Christian Lycke
    Elyazar, Iqbal
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Eshrati, Babak
    Esteghamati, Alireza
    Faraon, Emerito Jose Aquino
    Univ Philippines, Coll Publ Hlth, Manila, Philippines.;Dept Hlth, Manila, Philippines..
    Farid, Talha A.
    Farinha, Carla Sofia E. Sa
    Faro, Andre
    Farvid, Maryam S.
    Farzadfar, Farshad
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Joao C.
    Fischer, Florian
    Univ Bielefeld, Bielefeld, Germany. Acad Med Sci, Inst Gerontol, Kiev, Ukraine..
    Fitchett, Joseph R. A.
    Fleming, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gt, Nataliya Fo
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Franklin, Richard C.
    James Cook Univ, Townsville, Qld, Australia..
    Fraser, Maya S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pullman, Nancy
    Furst, Thomas
    Univ Basel, Basel, Switzerland..
    Futran, Neal D.
    Univ Washington, Seattle, WA USA..
    Gambashidze, Ketevan
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Gamkrelidze, Amiran
    Gebre, Teshome
    Task Force Global Hlth, Decatur, GA USA..
    Gebrehiwot, Tsegaye Tewelde
    Gebremedhin, Amanuel Tesfay
    Ludwig Maximilians Univ Munchen, Munich, Germany..
    Gebremedhin, Mengistu
    Gebru, Alemseged Aregay
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Gibney, Katherine B.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia..
    Giref, Ababi Zergaw
    Giroud, Maurice
    Univ Hosp Dijon, Dijon, France..
    Gishu, Melkamu Dedefo
    Glaser, Elizabeth
    Goenka, Shifalika
    Publ Hlth Fdn India, New Delhi, India..
    Gomez-Dantes, Hector
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Goto, Atsushi
    Graetz, Nicholas
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gugnani, Harish Chander
    Guo, Yuming
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Hafezi-Nejad, Nima
    Hailu, Alemayehu Desalegne
    Hailu, Gessessew Bugssa
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Hamadeh, Randah Ribhi
    Hamidi, Samer
    Hancock, Jamie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Handal, Alexis J.
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Harun, Kimani M.
    Univ Washington, Seattle, WA USA..
    Havmoeller, Rasmus
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hoy, Damian G.
    Htet, Aung Soe
    Hu, Guoqing
    Huang, Hsiang
    Huang, John J.
    Yale Univ, New Haven, CT USA..
    Huybrechts, Inge
    Huynh, Chantal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iannarone, Marissa
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Iyer, Veena J.
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Jakovljevic, Mihajlo B.
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Guohong
    Jiang, Ying
    Jibat, Tariku
    Wageningen Univ, Wageningen, Netherlands..
    Jonas, Jost B.
    Kabir, Zubair
    Kamal, Ritul
    Kan, Haidong
    Karch, Andre
    Karletsos, Dimitris
    Kasaeian, Amir
    Kaul, Anil
    Kawakami, Norito
    Kayibanda, Jeanne Francoise
    Kazanjan, Konstantin
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kazi, Dhruv S.
    Keiyoro, Peter Njenga
    Kemmer, Laura
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kemp, Andrew Haddon
    Univ Sydney, Sydney, NSW, Australia..
    Kengne, Andre Pascal
    Keren, Andre
    Kereselidze, Maia
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khang, Young-Ho
    Khonelidze, Irma
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Khosravi, Ardeshir
    Khubchandani, Jagdish
    Kim, Yun Jin
    Kivipelto, Miia
    Knibbs, Luke D.
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Koul, Parvaiz A.
    Koyanagi, Ai
    Krishnaswami, Sanjay
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kulkarni, Chanda
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kutz, Michael J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Lam, Hilton
    Lamadrid-Figueroa, Hector
    Lan, Qing
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Laryea, Dennis Odai
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    Li, Yichong
    Li, Yongmei
    Lipshultz, Steven E.
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Liu, Shiwei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Liu, Yang
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lotufo, Paulo A.
    Lunevicius, Raimundas
    Ma, Stefan
    El Razek, Hassan Magdy Abd
    El Razek, Mohammed Magdy Abd
    Majdan, Marek
    Majeed, Azeem
    Malekzadeh, Reza
    Mapoma, Chabila C.
    Marcenes, Wagner
    Margolis, David Joel
    Marquez, Neal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Masiye, Felix
    Marzan, Melvin Barrientos
    Mason-Jones, Amanda J.
    Mazorodze, Tasara T.
    Meaney, Peter A.
    Mehari, Alem
    Mehndiratta, Man Mohan
    Mena-Rodriguez, Fabiola
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia..
    Melaku, Yohannes Adama
    Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memish, Ziad A.
    Mendoza, Walter
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia. Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mhimbira, Francis Apolinary
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ibrahim, Norlinah Mohamed
    Mohammad, Karzan Abdulmuhsin
    Mohammadi, Alireza
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Mola, Glen Liddell D.
    Monasta, Lorenzo
    Monis, Jonathan De la Cruz
    Hernandez, Julio Cesar Montanez
    Montero, Pablo
    Montico, Marcella
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Moore, Ami R.
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg & Trop Med, London, England..
    Murthy, Srinivas
    Nachega, Jean B.
    Naheed, Aliya
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Nash, Denis
    Neupane, Subas
    Newton, John N.
    Ng, Marie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Le Nguyen, Quyen
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Nomura, Marika
    Norheim, Ole F.
    Norman, Rosana E.
    Nyakarahuka, Luke
    Obermeyer, Carla Makhlouf
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Opio, John Nelson
    Oren, Eyal
    Ota, Erika
    Oyekale, Abayomi Samuel
    Pa, Mahesh
    Pain, Amanda
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Papantoniou, Nikolaos
    Park, Eun-Kee
    Park, Hye-Youn
    Caicedo, Angel J. Paternina
    Patten, Scott B.
    Paul, Vinod K.
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Pillay, Julian David
    Pishgar, Farhad
    Polinder, Suzanne
    Pope, Daniel
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rafay, Anwar
    Rahimi, Kazem
    Univ Oxford, Oxford, England..
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Ram, Usha
    Ranabhat, Chhabi Lal
    Rangaswamy, Thara
    Rao, Paturi Vishnupriya
    Refaat, Amany H.
    Remuzzi, Giuseppe
    Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, 1775-1812 p.Article in journal (Refereed)
    Abstract [en]

    Background In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. Methods We estimated maternal mortality at the global, regional, and national levels from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories, 11 of which were analysed at the subnational level. We quantified eight underlying causes of maternal death and four timing categories, improving estimation methods since GBD 2013 for adult all-cause mortality, HIV-related maternal mortality, and late maternal death. Secondary analyses then allowed systematic examination of drivers of trends, including the relation between maternal mortality and coverage of specific reproductive health-care services as well as assessment of observed versus expected maternal mortality as a function of Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Findings Only ten countries achieved MDG 5, but 122 of 195 countries have already met SDG 3.1. Geographical disparities widened between 1990 and 2015 and, in 2015, 24 countries still had a maternal mortality ratio greater than 400. The proportion of all maternal deaths occurring in the bottom two SDI quintiles, where haemorrhage is the dominant cause of maternal death, increased from roughly 68% in 1990 to more than 80% in 2015. The middle SDI quintile improved the most from 1990 to 2015, but also has the most complicated causal profile. Maternal mortality in the highest SDI quintile is mostly due to other direct maternal disorders, indirect maternal disorders, and abortion, ectopic pregnancy, and/or miscarriage. Historical patterns suggest achievement of SDG 3.1 will require 91% coverage of one antenatal care visit, 78% of four antenatal care visits, 81% of in-facility delivery, and 87% of skilled birth attendance. Interpretation Several challenges to improving reproductive health lie ahead in the SDG era. Countries should establish or renew systems for collection and timely dissemination of health data; expand coverage and improve quality of family planning services, including access to contraception and safe abortion to address high adolescent fertility; invest in improving health system capacity, including coverage of routine reproductive health care and of more advanced obstetric care-including EmOC; adapt health systems and data collection systems to monitor and reverse the increase in indirect, other direct, and late maternal deaths, especially in high SDI locations; and examine their own performance with respect to their SDI level, using that information to formulate strategies to improve performance and ensure optimum reproductive health of their population.

  • Nylander, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Nylander, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Where the real change happens?: Global climate governance from below: investigating the COP counter summit in Paris 20152017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Ever since the governments began to meet for the Conferences of the Parties (COP) to try to come to agreement over an international climate agreement, civil society organizations involved in the climate issue have also gathered for their own conferences in relation to the COP. Still the role of these re-occurring “COP counter summits” in global climate governance have not been researched in depth. In order to contribute to a better understanding of the role the COP counter summit in climate governance in general, the aim of this study is to conduct a qualitative single-case study of one of these meetings. This is carried out by a field study to the COP counter summit in Paris 2015 with methods of participatory observation and semi-structured interviews with informants. An analytical framework was developed based on theory within related research fields, like parallel summits, social movements and globalization studies. The study contributes with research about what functions of the COP counter summit in Paris had for civil society and how these functions were performed.

  • ten Berge, Josianne C.
    et al.
    Erasmus Univ, Med Ctr, Dept Ophthalmol, Rotterdam, Netherlands..
    ten Berge, Josianne C.
    Erasmus Univ, Med Ctr, Dept Ophthalmol, Rotterdam, Netherlands..
    van Rosmalen, Joost
    Erasmus Univ, Med Ctr, Dept Biostat, Rotterdam, Netherlands..
    Vermeer, Jacolien
    Erasmus Univ, Med Ctr, Dept Immunol, Rotterdam, Netherlands..
    Hellström, Cecilia
    KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden..
    Lindskog, Cecilia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Nilsson, Peter
    KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden..
    Qundos, Ulrika
    KTH Royal Inst Technol, Sch Biotechnol, SciLifeLab, Affin Prote, Stockholm, Sweden..
    Rothova, Aniki
    Erasmus Univ, Med Ctr, Dept Ophthalmol, Rotterdam, Netherlands..
    Schreurs, Marco W. J.
    Erasmus Univ, Med Ctr, Dept Immunol, Rotterdam, Netherlands..
    Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, e0167909Article in journal (Refereed)
    Abstract [en]

    Purpose: Although multiple serum antiretinal autoantibodies (ARAs) have been reported in patients with paraneoplastic and non-paraneoplastic autoimmune retinopathy ((n)pAIR), not all retinal antigens involved in (n)pAIR are specified. This study aims to serologically identify patients with presumed (n)pAIR through determination of both known and unknown ARAs by autoantibody profiling.

    Methods: An antigen suspension bead array using 188 different antigens representing 97 ocular proteins was performed to detect ARAs in serum samples of patients with presumed (n)pAIR (n = 24), uveitis (n = 151) and cataract (n = 21). Logistic regressions were used to estimate the associations between ocular antigens and diagnosis. Validation of interphotoreceptor matrix proteoglycan 2 (IMPG2) and recoverin antigens was performed by immunohistochemistry and immunoblot, respectively.

    Results: Samples of patients with presumed (n)pAIR exhibited a broad spectrum of ARAs. We identified retinal antigens that have already been described previously (e.g. recoverin), but also identified novel ARA targets. Most ARAs were not specific for (n)pAIR since their presence was also observed in patients with cataract or uveitis. High titers of autoantibodies directed against photoreceptor-specific nuclear receptor and retinol-binding protein 3 were more common in patients with presumed (n)pAIR compared to uveitis (p = 0.015 and p = 0.018, respectively). The presence of all other ARAs did not significantly differ between groups. In patients with presumed (n)pAIR, anti-recoverin autoantibodies were the most prevalent ARAs. Validation of bead array results by immunohistochemistry (anti-IMPG2) and immunoblot (anti-recoverin) showed concordant results in (n)pAIR patients.

    Conclusions: Patients with (n)pAIR are characterized by the presence of a broad spectrum of ARAs. The diagnosis of (n)pAIR cannot be based on the mere presence of serum ARAs, as these are also commonly present in uveitis as well as in age-related cataract patients.

  • Englund, Sara
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Englund, Sara
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Nordström, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Samband mellan anhörigskattning och logopedisk bedömning vid afasi: I akut skede och sex månader efter stroke2016Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    One third of all patients with acute stroke acquire the language impairment aphasia. The assessment of aphasia is important in order to give a correct diagnosis and treatment. Two types of aphasia assessments are assessment of language function and assessment of functional communication (communication in everyday life). The assessment is usually performed by a speech and language pathologist (SLP) but it can also be performed by a family member or close friend with a proxy rating questionnaire. In this study the correlation between proxy rating of functional communication and SLP assessment of both language function and functional communication were examined. The assessments were performed at 16 days and 6 months after stroke onset. The study also examined if two proxy ratings correlated. The study was conducted using ANH and CETI proxy ratings, and the SLP assessments NGTA and ANELT. The results revealed a strong, statistically significant, correlation between proxy rating and SLP assessment and a very strong, statistically significant, correlation between the two proxy ratings. All correlations remained strong over time. When differences between proxy rating and SLP assessment were observed there was a tendency that proxies rated the functional communication higher than the SLP did. When the participants were divided into groups based on severity of aphasia, the results revealed a greater consistency between proxy rating and SLP assessment for people with mild aphasia than for those with moderate to severe aphasia. 

  • Olofsson, Julia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Olofsson, Julia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    El español - una lengua "chula": Un estudio cualitativo sobre las actitudes de alumnos de la escuela secundaria en Åland hacia el español.2015Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    A partir de entrevistas cualitativas, este trabajo estudia las razones por las que alumnos de la educación secundaria en Åland eligen el español como lengua extranjera en el año seis y sus actitudes hacia el español como asignatura y lengua después de haber estudiado la lengua desde aproximadamente medio año. Los resultados demuestran que la mayoría de los alumnos eligieron el español porque no tenían interés en estudiar el francés o el alemán. Además, el español les pareció fácil y divertido de aprender. La mayor parte de los alumnos indican tener actitudes positivas hacia tanto el español como asignatura y como lengua. Aprender el idioma de una manera comunicativa les parece beneficioso y también escuchar y leer textos españoles. Los alumnos aclaman que pueden sacar provecho del inglés dado que hay semejanzas entre las dos lenguas. Además, los alumnos tienen actitudes positivas hacia el ambiente de las clases, el contenido y los materiales de la enseñanza. Sin embargo, también hay los que tienen opiniones negativas hacia la asignatura porque para algunos alumnos el nivel les  parecen demasiado fácil o difícil.

  • Fryknäs, Mårten
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Fryknäs, Mårten
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Zhang, Xiaonan
    Linkping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.;Karolinska Inst, Dept Pathol & Oncol, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden..
    Bremberg, Ulf
    Beactica, SE-75450 Uppsala, Sweden..
    Senkowski, Wojciech
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Olofsson, Maria Hägg
    Karolinska Inst, Dept Pathol & Oncol, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden..
    Brandt, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Persson, Ingmar
    Swedish Univ Agr Sci, Dept Chem & Biotechnol, POB 7015, SE-75651 Uppsala, Sweden..
    D'Arcy, Padraig
    Linkping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden..
    Gullbo, Joachim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Nygren, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Schughart, Leoni Kunz
    Tech Univ Dresden, OncoRay Natl Ctr Radiat Res Oncol, D-01307 Dresden, Germany..
    Linder, Stig
    Linkping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.;Karolinska Inst, Dept Pathol & Oncol, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden..
    Larsson, Rolf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Iron chelators target both proliferating and quiescent cancer cells2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 38343Article in journal (Refereed)
    Abstract [en]

    Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revealed a striking similarity to signatures generated by compounds known to chelate iron. Validation experiments including addition of ferrous and ferric iron in excess, EXAFS measurements, and structure activity relationship analyses showed that VLX600 chelates iron and supported the hypothesis that the biological effects of this compound is due to iron chelation. Compounds that chelate iron possess anti-cancer activity, an effect largely attributed to inhibition of ribonucleotide reductase in proliferating cells. Here we show that iron chelators decrease mitochondrial energy production, an effect poorly tolerated by metabolically stressed tumor cells. These pleiotropic features make iron chelators an attractive option for the treatment of solid tumors containing heterogeneous populations of proliferating and quiescent cells.

  • Henriksson, Anna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Henriksson, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ådahl, Petter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Vem styr vem?: Makten över det möjligas gräns i ett gränslöst kontorslandskap.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats bygger på en observationsstudie som undersöker den aktivitetsbaserade kontorsmiljön utifrån hur den fysiska platsen och miljön styr och styrs av de människor och objekt som befinner sig på platsen. Syftet är att bidra till en djupare förståelse för hur makt kan manifesteras genom att handlande möjliggörs, uppmuntras och begränsas i fysiska rum, såväl av objekten som av människorna som befinner sig på platsen.

    Till skillnad från tidigare studier i fältet, som främst har fokuserat på hur det aktivitetsbaserade arbetssättet påverkat de anställdas hälsa, välmående och motivation, så ämnar denna uppsats att deskriptivt kartlägga den studerade kontorsmiljön och hur interaktionen mellan aktanter på arbetsplatsen ter sig. Detta görs genom att genomföra en deltagande observationsstudie på en arbetsplats med aktivitetsbaserad kontorsmiljö. Genom att utveckla och använda en teoretisk ansats baserad på främst Actor network theory utgångspunkter, Akrich (1992) begrepp script och de Certeaus (1984) begreppspar strategier och taktiker analyserar vi våra observationer på arbetsplatsen i strävan att undersöka hur aktanters handlande styr och styrs av den miljö de är en del av på kontoret.

    Studiens resultat visar att den aktivitetsbaserade kontorsmiljön i flera avseenden inte skiljer sig, eller skiljer sig marginellt, i praktiken från så kallade traditionella kontorslandskap. Kontorets utformning är beroende av de sociala och arbetsrelaterade relationerna mellan kollegor, som många gånger i högre grad förklarar strukturen på nätverket och dess möjliggörande av ett visst sätt att handla. Vidare visar analysen att vissa aktanter blir obligatoriska passagepunkter som definierar, formar och styr sin omgivning i relativt hög utsträckning. Produkten av relationerna på kontoret är den makt som manifesteras. Denna makt finns i alla typer av handlingar, men visar sig också vara en del av traditionellt studerade makrostrukturer som exempelvis intressekonflikten mellan arbete och kapital.

  • Muli, Irene Ngene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Muli, Irene Ngene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Tjänstemännens upplevelser och erfarenheter av utökad samhällsorientering i Stockholms län2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: According to Stockholm’s Public Health report refugees have lowest selfreported health and there are indicators of inadequate access to health care. All asylum seekers are offered a health assessment opportunity which less than half of them utilize. To address health problems within the group Stockholm County decided to extend an educational program for those who receive residence permit, with 12 hours health communication. Uppsala University was given the responsibility to evaluation the initiative.  

    Purpose: The purpose of this study was to illustrate the experiences of the involved officials of the initiative, the pros and cons of the initiative and areas of improvement.  

    Method: The data for this study was collect through semi-structured interviews with three different categories of officials. The collected data was analyzed using content analysis.  

    Results: One of the key benefits of the initiative was that it helped participants use health care. The partnership was perceived as successful because of the good communication. The officials expressed challenges regarding the length of the health communication and the struggle to meet the participant’s needs.   

    Conclusion: This study shows that the initiative addressed some of the barriers migrants face regarding utilizing health care. The partnership was success due to factors similar to those for other successful health promotion projects and partnerships. The challenges related to the length of the programme, which can be attributed to poor initial analysis of the problem, is together with linkage of the initiative areas of improvement. 

  • Public defence: 2017-02-10 10:15 Room 2446, Uppsala
    Almquist, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Almquist, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Efficient Simulation of Wave Phenomena2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Wave phenomena appear in many fields of science such as acoustics, geophysics, and quantum mechanics. They can often be described by partial differential equations (PDEs). As PDEs typically are too difficult to solve by hand, the only option is to compute approximate solutions by implementing numerical methods on computers. Ideally, the numerical methods should produce accurate solutions at low computational cost. For wave propagation problems, high-order finite difference methods are known to be computationally cheap, but historically it has been difficult to construct stable methods. Thus, they have not been guaranteed to produce reasonable results.

    In this thesis we consider finite difference methods on summation-by-parts (SBP) form. To impose boundary and interface conditions we use the simultaneous approximation term (SAT) method. The SBP-SAT technique is designed such that the numerical solution mimics the energy estimates satisfied by the true solution. Hence, SBP-SAT schemes are energy-stable by construction and guaranteed to converge to the true solution of well-posed linear PDE. The SBP-SAT framework provides a means to derive high-order methods without jeopardizing stability. Thus, they overcome most of the drawbacks historically associated with finite difference methods.

    This thesis consists of three parts. The first part is devoted to improving existing SBP-SAT methods. In Papers I and II, we derive schemes with improved accuracy compared to standard schemes. In Paper III, we present an embedded boundary method that makes it easier to cope with complex geometries. The second part of the thesis shows how to apply the SBP-SAT method to wave propagation problems in acoustics (Paper IV) and quantum mechanics (Papers V and VI). The third part of the thesis, consisting of Paper VII, presents an efficient, fully explicit time-integration scheme well suited for locally refined meshes.

  • Public defence: 2017-02-10 10:00 Zootissalen, Uppsala
    McFarlane, S. Eryn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    McFarlane, S. Eryn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Speciation and Metabolic rate: Insights from an avian hybrid zone2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The role of divergent climate adaptation in speciation has received surprisingly little scientific attention. My dissertation research focused on how resting metabolic rate (RMR) relates to the build up of prezygotic and postzygotic isolation in a natural Ficedula flycatcher hybrid zone. RMR is the amount of energy an organism needs to run its internal organs. Since RMR is related to life history traits and thermoregulation in other systems, it is likely to affect speciation processes at secondary contact. I found that adult collared flycatchers displace pied flycatchers into increasingly poor habitats (Paper I). Pied nestlings exhibit lower RMR in poor environments (Paper II), which may promote regional coexistence and habitat isolation by making it possible for pied flycatchers to escape competition from collared flycatchers and reduce the risk of hybridization by breeding in the poorer habitats. Further, I found that while collared flycatcher nestling RMR was not environmentally-dependent (Paper II, Paper III), those collared flycatcher nestlings that had a lower RMR in poor environments tended to have higher condition (Paper III). Further, RMR was genetically linked to a sexual ornament in collared males that has previously been shown to be beneficial in poor environments. Lastly, I found that by seven days old, nestlings increase their metabolic rate when listening to song, indicating that they are listening, and by 9 days they can discriminate between songs (Paper IV). Taken together, RMR could affect pre-zygotic isolation via correlations with life history strategies, song and sexual ornaments. RMR is also related to post zygotic isolation in Ficedula flycatchers. I found that flycatcher hybrids tended to have a higher RMR than the parental species (Paper V), and that there were many differentially expressed genes in energetically expensive organs in hybrids that were related to metabolic function (Paper VI). Thus, metabolic dysfunction, possibly caused by genetic incompatibilities, in Ficedula flycatcher hybrids could be a factor leading to infertility and postzygotic isolation between the parental species. Overall, I find that RMR could be a general physiological trait that affects both pre- and postzygotic isolation in hybridizing species at secondary contact, and ought to be more thoroughly considered in speciation research. 

  • Jobs, Magnus
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Jobs, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Wedberg, Rolf
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Gajewski, Konrad
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    DB Science 400 kW RF Station Site Acceptance Test2017Report (Other (popular science, discussion, etc.))
    Abstract [en]

    The manufactured and delivered DB-Science 400 kW RF station was tested on site at FREIA during 2016. The station can successfully deliver continuous pulse-trains with a power-level up to 400 kW, however during most of the on-site measurements and testing the total combiner output power was limited to 360 kW due to unusually high G2 currents measured in one of the spare TH595 tetrode tubes used in the station. Each of the stations 200 kW tetrode based amplifier sections were mounted with TH595 tetrode tubes from Thales and tuned for optimal performance. The gain of the tetrode amplifiers were roughly 15 dB with some variation between the two amplifier sections and the overall gain was approximately 74 dB maximum. Amplitude and phase pulse variations were within the specified levels.

  • Rosenkvist, Matilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Rosenkvist, Matilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Tragedias femeninas: Un estudio de los roles de género en la trilogía lorquiana2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    En esta tesina se analiza los roles de género en la trilogía lorquiana, que consiste en los dramas Bodas de sangre, Yerma y La casa de Bernarda Alba. El análisis se basa en la teoría feminista y la idea de que el género se produce culturalmente y que esta producción de género crea tanto distinciones como desigualdad entre los géneros. En todas las obras existen normas de género que se basan en la domesticidad, la pureza y la sumisión como características femeninas. Las normas son dicotomías y por eso las características masculinas son las opuestas. Como las normas están presentes en cada obra, todos los personajes femeninos más importantes tienen que enfrentarse a ellas. Su actitud varía entre el fortalecimiento y la transgresión y varios de los personajes fortalecen algunas de las normas mientras transgreden otras. Sin embargo, independientemente de su actitud ninguno de los personajes femeninos logra evitar el destino trágico que les asigna el sistema patriarcal presentado en la trilogía.

  • Höljö, Nikolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Höljö, Nikolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    El trasvase interlingüístico de las metáforas en La casa de Bernarda Alba: Un estudio comparativo del español al sueco2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    En esta tesina se analiza las diferencias entre las metáforas en La casa de Bernarda Alba y sus equivalentes en una traducción sueca. Nuestros análisis se basan en la teoría sobre las metáforas conceptuales de Lakoff y Johnson (1980) con su enfoque cognitivista, además de la teoría de Gottlob Frege y sus ideas sobre sentido y significado, en el momento de compararlas. Las metáforas traducidas presentan una variedad de maneras en la traducción de la metáfora: traducir la metáfora literalmente, sustituirla por otra metáfora en la lengua meta, traducirla como metáfora que no lo era en el original y sustituir la metáfora de la lengua origen por un símil en la lengua meta. Sin embargo, el trasvase interlingüístico de la metáfora, en muchos casos, no logra mantener las connotaciones de la lengua original, algo que muestra la influencia cultural pero que significa una pérdida de las connotaciones originales. El efecto positivo, por otra parte, es una mayor accesibilidad de las metáforas para los lectores suecos.

  • Gauthier, Cecilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Gauthier, Cecilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    ¿Lo tengo que hacer o tengo que hacerlo?: Diferencias semánticas entre la posición proclítica y enclítica del pronombre clítico lo en la perífrasis verbal tener que + infinitivo2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    La lingüística cognitiva opera bajo varios principios fundamentales, de los cuales uno describe que las variaciones sintácticas comprenden variaciones semánticas. Si bien es generalmente aceptado por la comunidad científica, pocos investigadores se han profundizado en el significado intrínseco de las alternancias de posicionamiento del pronombre clítico, fenómeno estructural posible dentro de algunos sistemas lingüísticos de lenguas romances, entre otras el español. El propósito de esta tesina es investigar qué diferencias semánticas pueden existir entre la posición antepuesta y pospuesta del clítico, examinando la perífrasis verbal tener que + infinitivo en construcciones con el pronombre clítico lo. El método es tanto cuantitativo como cualitativo; primeramente, se comprueba que sí existe una relación entre el hecho de usar o no la llamada subida de clítico con la lectura de modalidad de cada caso, para después intentar de explicar los casos que no parecieron ser afectados por las combinaciones más comunes de posición de clítico y modalidad. Los resultados obtenidos revelan que efectivamente existe una tendencia clara en cuanto a posición de clítico y modalidad, y que esta podría deberse a un componente de volitividad.   

  • Sten, Sabine
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Sten, Sabine
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Loven, Christian
    Riksarkivet,Box 12541, SE-10229 Stockholm, Sweden..
    Kjellstrom, Anna
    Stockholms Univ, Inst Arkeologi Antikens kultur, Osteologiska Skningslab, SE-10691 Stockholm, Sweden..
    Liden, Kerstin
    Stockholms Univ, Inst Arkeologi Antikens kultur, Arkeologiska Skningslabo, SE-10691 Stockholm, Sweden..
    Vretemark, Maria
    Vastergotlands Museum, SE-53232 Skara, Sweden..
    Vala, Cecilie Hongslo
    Univ Goteborgs, Enheten Geriatrik Inst Medicin, Sahlgrenska Akademin, SE-40530 Gothenburg, Sweden..
    Ljunggren, Östen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
    Fjällstrom, Markus
    Uppsala Univ, Arkeol Forskningslab, SE-75185 Uppsala, Sweden..
    Shalabi, Adel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Duvernoy, Olov
    Akad sjukhuset, Bild Fnnktionsmedicinskt Centrum, SE-75185 Uppsala, Sweden..
    Segelsjo, Monica
    Akad sjukhuset, Bild Fnnktionsmedicinskt Centrum, SE-75185 Uppsala, Sweden..
    Malmstrom, Helena Jankovic
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Jakobsson, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Erik den heliges skelett2016In: Fornvännen, ISSN 0015-7813, E-ISSN 1404-9430, Vol. 111, no 1, 27-40 p.Article in journal (Refereed)
    Abstract [en]

    Saint Erik was King of Sweden for a few years up to 1160, when he was killed. A skeleton attributed to him is kept in Uppsala Cathedral. It underwent scientific reappraisal in 2014. The analyses included computer tomography, Xray absorptiometry, isotope analysis and DNA sampling. Radiocarbon confirms the alleged age of the bones. They belong to a 35-40-year-old man in excellent physical shape. The many wounds that he received in connection with his death fit surprisingly well with the saint's legend, whose preserved version was written 130 years after the event.

  • Brooks, S. J.
    et al.
    Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa..
    Brooks, S. J.
    Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa..
    Burch, K. H.
    Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa.;Univ Nottingham, Dept Neurosci, Nottingham NG7 2RD, England..
    Maiorana, S. A.
    Univ Cape Town, Dept Psychol, ZA-7700 Rondebosch, South Africa..
    Cocolas, E.
    Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa..
    Schiöth, Helgi B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Nilsson, Emil K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Kamaloodien, K.
    Univ Western Cape, Dept Psychol, Cape Town, South Africa..
    Stein, D. J.
    Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;Univ Cape Town, MRC Unit Anxiety & Stress Disorders, ZA-7700 Rondebosch, South Africa..
    Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use2016In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 12, 478-491 p.Article in journal (Refereed)
    Abstract [en]

    Background: Protracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known. Methods: 66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18-50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis. Results: TAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores. Conclusions: While psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.

  • Kjellberg, Katarina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Kjellberg, Katarina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Öhrström, Linnéa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Livet för personer med afasi och deras närstående efter stroke: Personer med afasi och deras närståendes skattningar på COAST respektive Carer COAST i relation till en språklig bedömning med testet A-ning2016Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    ABSTRACT

    Stroke can result in aphasia which is an acquired language disorder. It affects both the person with aphasia and the relatives. Previous studies have shown that people with aphasia consider themselves to have fewer difficulties with communication in comparison to their relatives’ opinions. The relatives rate the difficulties as less severe in comparison to the speech and language pathologists. The scales Communication Outcome after Stroke (COAST) and Carer Communication Outcome after Stroke (Carer COAST) can be used to investigate the experiences of the people with aphasia and their relatives regarding the language and communication ability of people with aphasia and the quality of life for both groups. By using COAST and Carer COAST this study aimed to investigate the experiences of people with aphasia and their relatives and to compare their experiences to the assessment of language. This study also aimed to start a validation of COAST and Carer COAST on a Swedish population. A qualitative and a quantitative analysis were used. Twenty people with aphasia and nineteen relatives were participating. The ratings between people with aphasia, their relatives and the speech and language pathologist did not differ a lot even though the relatives rated the difficulties as most severe. The quality of life was negatively affected for almost all participants. This study provided deeper insight in the different experiences which can be crucial in the clinical practice. The validation of COAST and Carer COAST can contribute to an extended use of the scales clinically and in research.

    Keywords: aphasia, stroke, relative, experiences, speech and language pathology, Communication Outcome after Stroke, Carer Communication Outcome after Stroke

    SAMMANFATTNING

    Afasi är en förvärvad språkstörning som kan uppkomma efter stroke och påverkar både personen som fått afasi och de närstående. Enligt tidigare studier anser personer med afasi att de har mindre kommunikationssvårigheter än vad de närstående upplever. De närstående upplever i sin tur svårigheterna som mindre än vad logopeder bedömer. Skattningsformulären Communication Outcome after Stroke (COAST) och Carer Communication Outcome after Stroke (Carer COAST) kan användas för att undersöka upplevelserna hos personer med afasi och deras närstående avseende den språkliga och kommunikativa förmågan hos personen med afasi samt livskvaliteten hos båda parter. Studien syftade till att med COAST och Carer COAST studera upplevelserna hos personer med afasi och deras närstående samt hur dessa förhöll sig till en språklig bedömning. Ytterligare ett syfte var att påbörja validering av COAST och Carer COAST på en svensk population. En kvalitativ och en kvantitativ analys gjordes. Tjugo personer med afasi och nitton närstående deltog. Det var inga större skillnader mellan skattningarna av deltagarna med afasi och deras närstående. Skattningarna stämde även till stor del överens med den språkliga bedömningen även om de närstående överlag skattade svårigheterna som störst. Livskvaliteten var negativt påverkad för de flesta deltagarna. Studiens resultat ökar insikten om de olika upplevelserna vilket kan vara av betydelse i den kliniska verksamheten. Valideringen av COAST och Carer COAST kan innebära att skattningsskalorna i större utsträckning kan användas kliniskt och inom forskning.

     

    Nyckelord: afasi, stroke, närstående, upplevelser, logopedi, Communication Outcome after Stroke, Carer Communication Outcome after Stroke

  • Lee, Kian Keat
    et al.
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Lee, Kian Keat
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Hao, Wenming
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Gustafsson, Mikaela
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Tai, Cheuk-Wai
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Morin, Daniel
    ABB Corp Res, Forskargrand 7, SE-72178 Vasteras, Sweden..
    Bjorkman, Eva
    Biokol Lilliestrale & Co KB, Sibyllegatan 53, SE-11443 Stockholm, Sweden..
    Lilliestrale, Malte
    Biokol Lilliestrale & Co KB, Sibyllegatan 53, SE-11443 Stockholm, Sweden..
    Björefors, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Andersson, Anna M.
    ABB Corp Res, Forskargrand 7, SE-72178 Vasteras, Sweden..
    Hedin, Niklas
    Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden..
    Tailored activated carbons for supercapacitors derived from hydrothermally carbonized sugars by chemical activation2016In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 112, 110629-110641 p.Article in journal (Refereed)
    Abstract [en]

    Activated carbons (ACs) are actively researched as electrode materials for supercapacitors and there is a significant interest to produce ACs from sustainable and low cost precursors. In this study, various ACs were prepared from hydrothermally carbonized sugars by KOH activation. Both the hydrothermal carbonization and activation processes were optimized to tailor the properties (e.g. textural properties, chemical composition, N-doping, electrical conductivity) of the ACs. For instance, the Brunauer-Emmett-Teller (BET) surface areas (S-BET) were tuned in the range of 800-3000 m(2) g(-1) with associated variation in the extent of microporosity and pore size distributions (PSDs). The ACs were evaluated electrochemically as materials for supercapacitor electrodes in a symmetrical two-electrode cell using an aqueous electrolyte. The relationship between the electrochemical, textural, electrical, and physicochemical properties were analyzed systematically to understand the key factors determining the electrochemical performance. A high specific capacitance (C-m) of similar to 260 F g(-1) was achieved at a moderately high S-BET of similar to 1300 m(2) g(-1), which was equivalent to a C-m/S-BET of 20 mu F cm(-2), for an optimal AC prepared from hydrothermally carbonized glucose. The very high surface-specific capacitance highlights that the specific surface area is certainly not the sole limiting parameter for effective electrode materials.

  • Hartler, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Hartler, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Language and pragmatic abilities in children with ADHD and/or Autism Spectrum Disorder: The importance of Speech and Language Pathologists in neurodevelopmental assessment2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Children with neurodevelopmental disorders like Attention Deficit Hyperactivity Disorder (ADHD) and/or Autism Spectrum Disorder (ASD) often suffer from variable impairments in language and pragmatic abilities. The purpose of this study was to investigate language and pragmatics in children with ADHD and/or ASD (D-group) compared with a control group with no diagnose (ND-group). 22 children with diagnose, 4 girls and 18 boys aged 9:4–13:6, and 26 children with typical development, 10 girls and 16 boys, aged 10:5–13:4 were tested with a battery of tests concerning language and pragmatics. Their parents filled in a questionnaire regarding pragmatic abilities. The D-group performed poorer than the ND-group in all tests. Correlations were found between several pragmatic and language tests results in the D-group, and a few correlations were found in the ND-group. Some tests were particularly difficult for the D-group. An attempt was made to find subgroups in the D-groups test results via cluster analysis, but without success. The results emphasize the need of routine speech-language pathologist assessment during diagnostic evaluation of children with neurodevelopmental disabilities.

  • Bergmann, Amanda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Bergmann, Amanda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Kjerrman, Corinne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Ett intraoperativt ordrepetitionstest på svenska: Baserat på det nederländska testbatteriet Dutch Linguistic Intraoperative Protocol2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Low-grade gliomas are brain tumours that grow slowly and infiltrate brain tissue. The tumours often infiltrate tissue that is responsible for important functions such as language and motor skills. Resection of tumours in eloquent areas is done during awake surgery, which means that the patient is awake and undergoing testing during the operation. Depending on the area being subjected to surgery and what functions are expected to be affected, different tests are used, which allows a more extensive resection. In language testing during awake surgery, the patient's linguistic abilities can be tested and accordingly be preserved to a greater extent. At Akademiska sjukhuset in Uppsala the language tests currently in use are tests for example visual object naming, sentence production and reading aloud. There has been a growing demand for a greater variety of tests to allow a closer linguistic assessment during surgery. The aim of this thesis is to create a word repetition test based on the Dutch test battery DuLIP, and to conduct a pilot test to evaluate the quality of the test. This resulted in a Swedish word repetition test. A pilot test, conducted on 15 participants, established which words to be included in the test. This test will be used at Akademiska sjukhuset in Uppsala, but can also be used throughout Sweden if desired.

  • Hellström, Charlotte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Hellström, Charlotte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Why We Shop: A study of political consumption in regards to fast fashion2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Purpose – The thesis examines and explains how political consumption is used by a group of students. Three hypotheses were formulated in order to test if information, motivation and social commitment lead to political consumption and if the political consumption behavior differs when buying clothes and groceries.

    Design/methodology/approach – Questionnaires were formulated and handed out to students attending a basic course in Political Science at Uppsala University. The data from this survey was coded and processed in SPSS in order to test the formulated hypotheses.

    Findings – The findings in the thesis show that political consumption differs between different industries in the studied population. No compelling evidence was however provided in order to confirm that information, motivation or social commitment lead to political consumption. It does however provide some indications on possible explanations that warrant further research.

    Research limitations – The results cannot be generalized to a wider population and thus only give indications on how political consumption can be explained.

    Keywords – political consumption, fast fashion, buycotts, boycotts, social capital 

  • Sand, Rebecca
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Sand, Rebecca
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    En överrepresentation av män?: En undersökning av inramningens betydelse för inställningen till könskvotering i svenska bolagsstyrelser.2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Wallin, Erika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Wallin, Erika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Representation och dialog i den moderna demokratin: En kvalitativ textanalys av Demokratiutredningens idéer om politisk representation och dialog mellan medborgare och politiker2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Muréus Selme, Martin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Muréus Selme, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Axelsson, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelse av information, kommunikation och delaktighet: En enkätstudie2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Information, communication and participation between health professionals and patients is a central element in the person-centered care. Great part of the health damages are related to communications failures.  Aim: The aim of the study was to investigate and describe hospitalized patients' experiences of information, communication and participation of their health, care and treatment.  Method: Quantitative non-exprimental cross-sectional study with descriptive design with qualitative elements. Participants were 36 patients hospitalized in a hospital in southern Sweden on medicine, surgeon, orthopedic, stroke or infection departments. The data collection took place in one week's time with the help of a survey. Data were analyzed with descriptive statistics.  Results: High results were shown for the total responses for requests for information, communication and participation. No significant differences were found between acute patients and elective. In the comparison between men and women´s experience, a significant difference was detected in terms of information on possible delays and if it was given enough privacy when the staff talked about his or her medical/health condition or care/treatment. For both questions, men estimated higher results. Conclusion: Positive results of the participants' perception of information, communication and participation regarding their health, care and treatment. To follow the developments that have occurred and still occurs on person-centered care need further research be done to ensure that patients understand the information communicated and feel involved in their care and treatment.  

  • Eliasson, Jonas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Eliasson, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Nymoen, Ronja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Får patienter adekvat smärtlindring på akutmottagning?: En litteraturstudie2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    SAMMANFATTNING  

    Bakgrund: Smärta är en subjektiv upplevelse som omfattar kroppsliga, känslomässiga och andliga komponenter. Smärta och lidande kan vara övergående som vid den akuta smärtan men kan också förekomma under en längre period. Akut smärta förekommer vid vävnadsskada i samband med operation, trauma, reumatiska sjukdomar samt tumörsjukdom. Den akuta smärtan avtar i samband med att vävnadsskadan läker. Svensk sjuksköterskeförening beskriver att lidande, som är en av värdegrunderna för omvårdnad, är kopplat till en persons upplevelse av sin situation samt en unik och individuell känsla. Litteraturen beskriver hur patienter upplever en bristfällig smärtlindring på akutmottagningar.

    Syfte: Syftet var att undersöka patienters tillfredsställelse av smärtlindring på akutmottagning samt vilka interventioner som beskrivs för att patienterna ska få en adekvat smärtlindring.

    Metod: En litteraturstudie som baseras på 11 originalartiklar från sökningar i PubMed och CINAHL.

    Resultat: Tre faktorer som för patienten ledde till en ökad tillfredsställelse med smärtbehandling på akutmottagning var: kommunikation mellan vårdgivare och patient, minskning i smärtintensitet samt adekvat smärtlindring. Det fanns olika resultat i artiklarna om sjuksköterskeinitierad smärtlindring hade positiv inverkan på patienternas tillfredsställelse eller inte. Interventionerna i studierna som analyserades var bland annat utbildning av personal och sjuksköterskeintiterad smärtprotokoll vilka ledde till att antalet patienter som erhöll smärtlindring ökade och tiden till smärtlindring minskade.

    Slutsats: Denna studie visar att kommunikation, information samt adekvat smärtlindring leder till en ökad tillfredsställelse med smärtbehandlingen, för patienten. Studien markerar också att det finns förbättringsåtgärder för smärtbehandling på akutmottagningar, så som utbildning för vårdpersonal, riktlinjer samt smärtbedömning. Dessa åtgärder leder till att patienterna erhåller adekvat smärtlindring.

    Nyckelord: Smärtlindring, Smärtbehandling, Patienttillfredsställelse, Akutmottagning.

  • Öhman, Lisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Öhman, Lisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The Importance of Educating Girls: A critical discourse analysis of western development approaches to girls’ education2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Lindbäck, Jennifer
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lindbäck, Jennifer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lamell, Amanda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Att leva med en inflammatorisk tarmsjukdom: En litteraturöversikt2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Fichtel, Mikaela
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Fichtel, Mikaela
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Bäcklund, Elin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sexuell hälsa i en vårdkontext: Hindrande och främjande faktorer för sjuksköterskans samtal om sexuell hälsa med patienten2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The World Health Organization regards sexual health as a significant part of good health, well-being and quality of life. Sexual health can in different ways be affected by illness, but is nevertheless an important aspect of health. The nurse has a responsibility to care for the patient from a holistic perspective where all aspects of health are taken into account. Despite this, sexual health is often a neglected subject in health care and in dicussions with patients.

    Aim: The aim of this study was to examine what factors acts as barriers and facilitators for the nurse to discuss sexual health with the patient.

    Method: A structured literature review. The result is based on a total of 12 articles, with both qualitative and quantitative methods.

    Results: A total of 53 factors were identified, 35 inhibited factors and 18 promoting factors. The factors resulted in following eight categories; a taboo subject, insufficient resources and conditions, lack of education, training and knowledge, the nurse's attitude and the patient's characteristics, sufficient resources and conditions, adequate education, training and knowledge, experience and confidence and the nurse-patient relationship.

    Conclusion: Sexual health is perceived to be a sensitive topic to talk about with patients. It is important to identify barriers and to apply appropriate methods to overcome them. Education can contribute to greater knowledge and awareness of sexual health and further promote the conversations. Regulatory documents and guidelines should be developed to provide nurses adequate tools to use in the conversation with the patient. These tools may contribute to good conversations between the patient and the nurse. The nurse should regard sexual health as an integral part of the holistic care.

  • Ekeroth, Nina
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Ekeroth, Nina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kotz, Josefin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Konflikthantering i förskolan: En studie om förskollärarens roll och strategier2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Holmberg, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Holmberg, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Wear and degradation of rock drill buttons with alternative binder phase in granite and sandstone2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis, drill bit buttons with cobalt, nickel and iron binders in different compositions have been tested against granite and sandstone and the wear and friction have been measured. Furthermore, the wear and degradation of the buttons have been categorized.

    Buttons with cobalt binder were tested against granite and sandstone and buttons with alternative binders (Ni, Fe, Co) were tested against granite. Cobalt buttons were used as a reference and the wear and friction of the alternative binders was compared to the reference. The amount of worn rock was also measured. Furthermore, post treated drill bit buttons with a composition of Fe-Ni-Co were compared to buttons with the same composition that had not been post treated

    The results show that buttons with an alternative composition of Fe-Co-Ni and Fe- Ni wears less than the cobalt reference. The post treatment process does not decrease the wear of the drill bit but lowers the deviation from the mean wear. The amount of worn rock does not differ between the samples except for between the post treated and not post treated buttons with a composition of Fe-Ni-Co. The post treated buttons produces more rock debris than the not post treated. No apparent difference could be seen on the surface of the tested buttons after the test. However, composition specific cracks could be found underneath the surface of the samples. EDS-analysis showed signals of oxygen inside of all of the investigated cracks. For some compositions at depths of 20 micrometers.

    The curves of friction shows similar appearance but the values of the coefficient of friction differs. No apparent correlation was found between the wear and friction of the samples. Furthermore, no apparent correlation was found between the hardness and the wear of the buttons. 

  • skoglund, vilhelm
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    skoglund, vilhelm
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Intressentinkludering i hållbarhetsredovisning: En utvärderande jämförelse av ett utvecklat land och ett utvecklingsland2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Under senare tid har allt fler företag börjat hållbarhetsredovisa, vilket innebär att de på årlig basis sammanställer och kommunicerar information om miljömässiga, sociala och ekonomiska aspekter av sin verksamhet. Hållbarhetsredovisning kan stötta hållbar utveckling på två huvudsakliga sätt. För det första kan det öka transparensen i samhället genom att förbättra tillgång till samt utgöra en plattform för att lämna och hantera hållbarhetsrelaterad information om företag. För det andra kan det stärka hållbarhetsarbete inom företag genom att de får insikt i hur de inverkar på omvärlden samt bereder dem strukturer och mål för hållbarhetsarbete.

    För att fylla dessa funktioner krävs emellertid att företag inkluderar aktörer som påverkas av och påverkar företaget, s.k. intressenter, i upprättandet av hållbarhetsredovisningen. En central princip inom hållbarhetsredovisning är följaktligen intressentinkludering. I denna uppsats utvärderar och jämför jag intressentinkludering i hållbarhetsredovisning i det utvecklade landet Spanien och utvecklingslandet Colombia genom innehållsanalys av tio hållbarhetsredovisningar från företag i respektive land. Jag finner, i likhet med tidigare forskning, att intressentinkludering i hållbarhetsredovisning är bristfällig, särskilt i utvecklingslandet Colombia. Härtill bidrar jag till existerande forskning genom att närmare beskriva på vilket sätt intressentinkludering i hållbarhetsredovisning är bristfällig samt skiljer sig mellan det utvecklade landet Spanien och utvecklingslandet Colombia.

  • Acosta, Cecilia M.
    et al.
    Hosp Privado Comunidad Mar Del Plata, Dept Anesthesia, Cordoba 4545, RA-7600 Buenos Aires, DF, Argentina..
    Acosta, Cecilia M.
    Hosp Privado Comunidad Mar Del Plata, Dept Anesthesia, Cordoba 4545, RA-7600 Buenos Aires, DF, Argentina..
    Tusman, Gerardo
    Hosp Privado Comunidad Mar Del Plata, Dept Anesthesia, Cordoba 4545, RA-7600 Buenos Aires, DF, Argentina..
    Costantini, Mauro
    Hosp Privado Comunidad Mar Del Plata, Dept Anesthesia, Cordoba 4545, RA-7600 Buenos Aires, DF, Argentina..
    Echevarria, Camila
    Hosp Privado Comunidad Mar Del Plata, Dept Radiol, Buenos Aires, DF, Argentina..
    Pollioto, Sergio
    Hosp Privado Comunidad Mar Del Plata, Dept Pediat Surg, Buenos Aires, DF, Argentina..
    Abrego, Diego
    Hosp Privado Comunidad Mar Del Plata, Dept Pediat Surg, Buenos Aires, DF, Argentina..
    Suarez-Sipmann, Fernando
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hedenstierna laboratory. Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain..
    Bohm, Stephan H.
    Swisstom AG, Landquart, Switzerland..
    Doppler images of intra-pulmonary shunt within atelectasis in anesthetized children2016In: Critical Ultrasound Journal, ISSN 2036-3176, E-ISSN 2036-7902, Vol. 8, 19Article in journal (Refereed)
    Abstract [en]

    Background: Doppler images of pulmonary vessels in pulmonary diseases associated with subpleural consolidations have been described. Color Doppler easily identifies such vessels within consolidations while spectral Doppler analysis allows the differentiation between pulmonary and bronchial arteries. Thus, Doppler helps in diagnosing the nature of consolidations. To our knowledge, Doppler analysis of pulmonary vessels within anesthesia-induced atelectasis has never been described before. The aim of this case series is to demonstrate the ability of lung ultrasound to detect the shunting of blood within atelectatic lung areas in anesthetized children.

    Findings: Three anesthetized and mechanically ventilated children were scanned in the supine position using a high-resolution linear probe of 6-12 MHz. Once subpleural consolidations were detected in the most dependent posterior lung regions, the probe was rotated such that its long axis followed the intercostal space. In this oblique position, color Doppler mapping was performed to detect blood flow within the consolidation. Thereafter, pulsed waved spectral Doppler was applied in the previously identified vessels during a short expiratory pause, which prevented interferences from respiratory motion. Different flow patterns were identified which corresponded to both, pulmonary and bronchial vessels. Finally, a lung recruitment maneuver was performed which leads to the complete resolution of the aforementioned consolidation thereby confirming the pathophysiological entity of anesthesia-induced atelectasis.

    Conclusions: Lung ultrasound is a non-invasive imaging tool that not only enables the diagnosis of anesthesia-induced atelectasis in pediatric patients but also analysis of shunting blood within this consolidation.

  • de Wit, Heleen A.
    et al.
    Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway..
    de Wit, Heleen A.
    Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway..
    Valinia, Salar
    Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway..
    Weyhenmeyer, Gesa A.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Futter, Martyn N.
    Swedish Univ Agr Sci, Dept Aquat Sci & Assessment, Lennart Hjalms Vag 9, S-75007 Uppsala, Sweden..
    Kortelainen, Pirkko
    Finnish Environm Inst, POB 140, Helsinki 00251, Finland..
    Austnes, Kari
    Norwegian Inst Water Res NIVA, Gaustadalleen 21, N-0349 Oslo, Norway..
    Hessen, Dag O.
    Univ Oslo, Sect Aquat Biol & Toxicol, Dept Biosci, N-0316 Oslo, Norway..
    Räike, Antti
    Finnish Environm Inst, POB 140, Helsinki 00251, Finland..
    Laudon, Hjalmar
    Swedish Univ Agr Sci, Dept Forest Ecol & Management, S-90183 Umea, Sweden..
    Vuorenmaa, Jussi
    Finnish Environm Inst, POB 140, Helsinki 00251, Finland..
    Current Browning of Surface Waters Will Be Further Promoted by Wetter Climate2016In: ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, ISSN 2328-8930, Vol. 3, no 12, 430-435 p.Article in journal (Refereed)
    Abstract [en]

    Browning of surface waters because of increasing terrestrial dissolved organic carbon (OC) concentrations is a concern for drinking water providers and can impact land carbon storage. We show that positive trends in OC in 474 streams, lakes, and rivers in boreal and subarctic ecosystems in Norway, Sweden, and Finland between 1990 and 2013 are surprisingly constant across climatic gradients and catchment sizes (median, +1.4% year(-1); interquartile range, +0.8-2.0% year(-1)), implying that water bodies across the entire landscape are browning. The largest trends (median, +1.7% year(-1)) were found in regions impacted by strong reductions in sulfur deposition, while subarctic regions showed the least browning (median, +0.8% year(-1)). In dry regions, precipitation was a strong and positive driver of OC concentrations, declining in strength moving toward high rainfall sites. We estimate that a 10% increase in precipitation will increase mobilization of OC from soils to freshwaters by at least 30%, demonstrating the importance of climate wetting for the carbon cycle. We conclude that upon future increases in precipitation, current browning trends will continue across the entire aquatic continuum, requiring expensive adaptations in drinking water plants, increasing land to sea export of carbon, and impacting aquatic productivity and greenhouse gas emissions.

  • Andersson, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Andersson, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Individualized mathematical modeling of neural activation in electric field2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Deep Brain Stimulation (DBS) is a treatment of movement disorders such as Parkinson's disease and essential tremor. Today it has been used in more than 80.000 patients. Electrical stimulation is administered by an implanted pulse generator through an electrode surgically placed in a target brain area specific to the treated disease. Opposed to alternative purely surgical treatment procedures, DBS is reversible and can be turned off.

    In this project, the aim is to individualise an already existing computational model of DBS, but also to look at optimisation of the treatment by developing a neuron model. It has been executed the following way. To localise the target area for the electrode, Magnetic Resonance Imaging (MRI) is used. An MRI image consists of volume elements called voxels. By analysing these voxels, it is possible to set up a coordinate system for the position of different parts of the brain. To build up an individualised model of the DBS, an MRI image is segmented into tissues of different conductivity thus resulting in a more accurate description of the electrical field around the electrode. To visualize the stimuli coverage for the medical staff, the MRI image of the target area, the electrode, and the electrical field produced by the stimuli are depicted in the same figure. From the results, we can draw the conclusion that this method works well for individualising the computational model of DBS, but it has only been used on one MRI scan so far so it needs further testing to obtain more data to compare with.

    The neuron model is a temporospatial mathematical model of a single neuron for the prediction of activation by a given electrically applied field generated by a DBS lead. The activation model is intended to be part of a patient-specific model of an already existing computational model of DBS. The model originate from a neuron model developed by Hodgkin and Huxley (HH). The original HH model only takes into account one compartment and, to make the neuron model more accurate, it is combined with a cable model. The simulation results obtained with the model have been validated against an established and widely accepted neuron model. The results correlated highly to each other with only minor differences. To see how position and orientation impact on activation, the developed HH model was tested for different pulse widths, distances from the lead, and rotations of the neuron relative to the lead. A larger pulse width makes activation more likely and so does a larger amplitude. Thicker neurons are more likely to get activated, neurons closer to the lead and also neurons perpendicular to the lead. From the results we can draw the conclusion that this method is a good way to stimulate neural activation of a single neuron. In future research, it might be possible to compare results from the neuron model with patient's response to treatment.