Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
1234567 1 - 50 of 1418
rss atomLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
  • Renmarker, Emmi
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Vikten av våra älskade husdjur: En studie i produktionen och konsumtionen av animalprodukter i Västergarn på Gotland under sen vikingatid och tidig medeltid2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis aims to deduce whether indications of the production of animal products can be observed in the osteological material from the property Snauvalds 1:2, Västergarn, Gotland. These productions can consist of meat-, dairy- or wool production. It also aims to provide an insight into ancient economy through the trade in animal products. In the osteological analysis age and sex assessment as well as species identification are used to establish a pattern of distribution. The results from the analysis have then been interpreted from an economic perspective to draw conclusions about the trade in and importance of animal products. The results showed that the cattle have likely been used for both dairy and meat production. The sheep were probably mainly used to produce wool, but also meat. The pigs were raised solely for their meat. In addition to this, it’s concluded that commodity money likely was an important part of the economy at the site. Lastly, it’s stated that this type of research provides a unique insight into everyday life through dietary choices and occupation.

    Download full text (pdf)
    fulltext
  • Fan, Weiwei
    et al.
    Dalian Polytech Univ, Sch Food Sci & Technol, Ctr Expt Instrument, Dalian 116034, Peoples R China.;Dalian Univ Technol, Sch Bioengn, Dalian 116024, Peoples R China..
    Wang, Zhenyu
    Dalian Polytech Univ, Sch Food Sci & Technol, Ctr Expt Instrument, Dalian 116034, Peoples R China..
    Mu, Zhishen
    Inner Mongolia Mengniu Dairy Ind Grp Co Ltd, Hohhot 010000, Peoples R China..
    Du, Ming
    Dalian Polytech Univ, Sch Food Sci & Technol, Ctr Expt Instrument, Dalian 116034, Peoples R China..
    Jiang, Lianzhou
    Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China..
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China..
    Wang, Cong
    Dalian Polytech Univ, Sch Food Sci & Technol, Ctr Expt Instrument, Dalian 116034, Peoples R China.;Inner Mongolia Mengniu Dairy Ind Grp Co Ltd, Hohhot 010000, Peoples R China..
    Characterizations of a Food Decapeptide Chelating with Zn(II)2020In: EFOOD, ISSN 2666-3066, Vol. 1, no 4, p. 326-331Article in journal (Refereed)
    Abstract [en]

    Walnut proteins and peptides have been reported to have great zinc-carrying activity. In this study, the decapeptide EPNGLLLPQY (WP-10) derived from walnut protein has been prepared to figure out zinc binding mechanisms and structure-activity relationships. The space-conformation of this peptide has converted after being chelated with Zn(II). As to secondary structure, the beta-sheet structure of the peptide turned into alpha-helix and beta-turn structure. According to the atomic absorption spectra analysis, one peptide could bind with one Zn(II) via four different binding sites. The signals of different groups in infrared spectroscopy have shifted before and after chelation, and the major functional groups of this peptide involved in chelation are -NH2 and -C=O. GLU1, PRO2, ASP3, GLU4, and LEU6, and the molecular docking proved their participation in the chelating with Zn(II). (c) 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

    Download full text (pdf)
    FULLTEXT01
  • Ivarsson, Adam
    Sveriges lantbruksuniversitet, SLU; Swedish University of Agricultural Sciences; Department of Energy and Technology; Environmental Engineering.
    Evaluation of storm- and rainwater recycling systems in Scandinavia2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study examined the current state of storm- and rainwater recycling for non-potable purposes in Scandinavia as well as the local conditions and challenges that influence the sustainability of storm- and rainwater recycling. Particularly, this study aimed to show how well existing storm- and rainwater recycling systems have performed, relative to the level of ambition held by the project owner and try to gauge their sustainability relative to traditional drinking water production systems. To achieve this, a literature study, a series of interviews with project owners and a multi-criteria analysis were conducted. 

    The evaluated storm- and rainwater recycling systems performed well at both larger and smaller scales, although this was not uniform. Generally, more simple systems with minimal treatment performed better. The relative lack of experience with the systems, regulatory uncertainties as well as the cold climate were all challenges that the storm- and rainwater recycling systems faced. 

    Broadly, the owners of the systems reported high levels of contentment with the systems and the quality of the water, but motivations for installing the systems varied between regions. Difficulties encountered generally pertained to issues that arose from the design, such as the storage being underdimensioned, or the turbidity of the water in open storage being too high, complicating treatment. 

    There appears to be potential for applying storm- and rainwater recycling at scale in Scandinavia. In theory, such technologies deployed at scale could help ease the demand for drinking water in all Scandinavian nations. Overall, storm- and rainwater recycling may not be a panacea for the water-related challenges brought on by climate change and industrial activity, but they can be part of a solution and alleviate some issues like water shortages.

    Download full text (pdf)
    fulltext
  • Lindqvist, Magnus
    et al.
    Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Leth-Moller, Katja Biering
    Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Ctr Clin Res & Prevent, Frederiksberg, Denmark..
    Linneberg, Allan
    Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Ctr Clin Res & Prevent, Frederiksberg, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark..
    Kull, Inger
    Karolinska Inst, Sodersjukhuset, Sachs Children & Youth Hosp, Dept Clin Sci & Educ, Stockholm, Sweden..
    Bergstrom, Anna
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden..
    Georgellis, Antonios
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden..
    Borres, Magnus P.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Ekebom, Agneta
    Swedish Museum Nat Hist, Dept Environm Res & Monitoring, Palynol Lab, Stockholm, Sweden..
    van Hage, Marianne
    Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Melen, Erik
    Karolinska Inst, Sodersjukhuset, Sachs Children & Youth Hosp, Dept Clin Sci & Educ, Stockholm, Sweden..
    Westman, Marit
    Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.;Praktikertjanst, Asthma & Allergy Clin St Goran, Stockholm, Sweden..
    Natural course of pollen-induced allergic rhinitis from childhood to adulthood: A 20-year follow up2024In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 79, no 4, p. 884-893Article in journal (Refereed)
    Abstract [en]

    Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide. There are limited prospective long-term data regarding persistency and remission of AR. The objective of this study was to investigate the natural course of pollen-induced AR (pollen-AR) over 20 years, from childhood into early adulthood.

    Methods: Data from 1137 subjects in the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic birth cohort (BAMSE) with a completed questionnaire regarding symptoms, asthma, treatment with allergen immunotherapy (AIT) and results of allergen-specific IgE for inhalant allergens at 4, 8, 16 and 24 years were analyzed. Pollen-AR was defined as sneezing, runny, itchy or blocked nose; and itchy or watery eyes when exposed to birch and/or grass pollen in combination with allergen-specific IgE >= 0.35kUA/L to birch and/or grass.

    Results: Approximately 75% of children with pollen-AR at 4 or 8 years had persistent disease up to 24 years, and 30% developed asthma. The probability of persistency was high already at low levels of pollen-specific IgE. The highest rate of remission from pollen-AR was seen between 16 and 24 years (21.5%); however, the majority remained sensitized. This period was also when pollen-specific IgE-levels stopped increasing and the average estimated annual incidence of pollen-AR decreased from 1.5% to 0.8% per year.

    Conclusion: Children with pollen-AR are at high risk of persistent disease for at least 20 years. Childhood up to adolescence seems to be the most dynamic period of AR progression. Our findings underline the close cross-sectional and longitudinal relationship between sensitization, AR and asthma.

    Download full text (pdf)
    fulltext
  • Rieger, Philipp
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Enhancing Atomic Spin Dynamics Simulations with GPU Acceleration2023Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This report presents the significant advancements made in the UppASD software package, a tool for atomic spin dynamics simulations, through the integration of GPU acceleration. Originally developed at Uppsala University, UppASD primarily utilized CPU-based computations. This project aimed to enhance its computational efficiency and capability by extending and rigorously evaluating its GPU-based implementation. The focus was on integrating a variety of magnetic interactions, including tensorial coupling, anisotropy models, and the Dzyaloshinskii-Moriya interaction, into the GPU framework. We also assessed the impact of GPU acceleration on the calculation of key observables. The methodology involved a comprehensive evaluation of the existing code structure, meticulous debugging, and performance benchmarking. This report details the development process, highlights the challenges encountered, and provides insights into future directions for the UppASD project.

    Download full text (pdf)
    fulltext
  • Ji, Fuxiang
    et al.
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Klarbring, Johan
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Zhang, Bin
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Wang, Feng
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Wang, Linqin
    Westlake Univ, Ctr Artificial Photosynth Solar Fuels, Sch Sci, Hangzhou 310024, Peoples R China..
    Miao, Xiaohe
    Westlake Univ, Instrumentat & Serv Ctr Phys Sci, Hangzhou 310024, Peoples R China..
    Ning, Weihua
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden.;Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Adv Negat Carbon Technol, Suzhou 215123, Peoples R China..
    Zhang, Muyi
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Cai, Xinyi
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Bakhit, Babak
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Magnuson, Martin
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Ren, Xiaoming
    Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China.;Nanjing Tech Univ, Coll Chem & Mol Engn, Nanjing 210009, Peoples R China..
    Sun, Licheng
    Westlake Univ, Ctr Artificial Photosynth Solar Fuels, Sch Sci, Hangzhou 310024, Peoples R China..
    Fahlman, Mats
    Linköping Univ, Dept Sci & Technol, S-60174 Norrköping, Sweden..
    Buyanova, Irina A.
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Chen, Weimin M.
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Simak, Sergei I.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Abrikosov, Igor A.
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Gao, Feng
    Linköping Univ, Dept Phys Chem & Biol IFM, SE-58183 Linköping, Sweden..
    Remarkable Thermochromism in the Double Perovskite Cs2NaFeCl62024In: Advanced Optical Materials, ISSN 2162-7568, E-ISSN 2195-1071, Vol. 12, no 8Article in journal (Refereed)
    Abstract [en]

    Lead-free halide double perovskites (HDPs) have emerged as a new generation of thermochromic materials. However, further materials development and mechanistic understanding are required. Here, a highly stable HDP Cs2NaFeCl6 single crystal is synthesized, and its remarkable and fully reversible thermochromism with a wide color variation from light-yellow to black over a temperature range of 10 to 423 K is investigated. First-principles, density functional theory (DFT)-based calculations indicate that the thermochromism in Cs2NaFeCl6 is an effect of electron-phonon coupling. The temperature sensitivity of the bandgap in Cs2NaFeCl6 is up to 2.52 meVK(-1) based on the Varshni equation, which is significantly higher than that of lead halide perovskites and many conventional group-IV, III-V semiconductors. Meanwhile, this material shows excellent environmental, thermal, and thermochromic cycle stability. This work provides valuable insights into HDPs' thermochromism and sheds new light on developing efficient thermochromic materials.

    Download full text (pdf)
    fulltext
  • Oja, Dennis
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    I gränslandet mellan språk och litteratur: En studie av hur svenskämnets språkliga och litterära delar integreras i läromedel på gymnasiet2024Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna ämnesdidaktiska studie undersöker hur svenskämnets språkliga och litterära delar integreras i läromedel för svenska på gymnasiet. Tidigare forskning visar att skönlitteraturen kan fungera språkutvecklande genom att bland annat vidga elevernas ordförråd och att grammatikundervisning kan utgå från skönlitterära texter. Forskningen visar också att det finns en relation mellan läsning och skrivande och att dessa förmågor kan berika varandra. Dessutom framhäver forskningen de språkliga aspekter som lyriken rymmer. Denna studie genomför en abduktiv tematisk analys där analysens teman tas fram både ur tidigare forskning och ur de studerade läromedlen. Studien visar att ämnets språkliga och litterära delar möts genom att läromedlen låter eleverna utveckla både sina skriftliga och muntliga förmågor genom uppgifter som utgår från skönlitteraturen. Dessutom tar alla läromedel tillvara på lyrikens språkliga potential samt låter eleverna arbeta med språklig variation genom skönlitteraturen på olika sätt. Analysen finner också belägg för när eleverna genom läsning och arbete med skönlitteratur får utveckla sitt språk. Jämförelsen mellan läromedlen visar också att de skriftliga och muntliga uppgifter som presenteras i det nyaste läromedlet har tillhörande bedömningsmatriser med fokus på både litterära och muntliga eller skriftliga förmågor, till skillnad från de äldre läromedlen som saknar denna explicita integrering.

    Download full text (pdf)
    fulltext
  • Harmsen, Elma
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    A Future Perspective on the Digitalised Work Environment: Understanding the Role of Artificial Intelligence and Social Robots in Future Work Environments2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Advanced technologies have made their way into the digitalisation process of many work environments, thereby inevitably changing therole technologies such as Artificial Intelligence and robotisation will start to play in future work environments. This thesis seeks answersto the question of how we can effectively understand the future role of technology in our digital work environment, with its main researchquestion being: How can the future role of Artificial Intelligence and social robots in a digitalised work environment be understood froma higher education perspective? The research includes a structured literature review on the current implications of digitalisation in workenvironments, a thematic analysis for patterns in the literature, and the futuring method covering several future scenarios related to twomain technological trends: Artificial Intelligence and robotisation. The outcomes of the futuring method translated to storyboards, formingthe basis for two discussions with university students, and providing important future perspectives on the before mentioned technologicaltrends. Findings emphasise the benefits of discussions of this kind; that they leverage how one now understands, and inherently definesand expects the use of AI and robot technologies in a digital work environment context. The future perspectives from the discussionsconsider primarily the factors of emotion, empathy, feelings and lived experiences, that discern and define the role of AI and robots in thephysical, cognitive and social-organisational dimensions of the digitalised work environment.

    Download full text (pdf)
    fulltext
  • Cherry, Arthur
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Plasma density variations in the ionosphere and their effects on trans-ionospheric signals: an investigation using Swarm satellite data and Lantmäteriet’s ionosphere monitor2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    We study plasma density variations within the ionosphere and their effects on trans-ionospheric signals, with a geodetic focus on Sweden from 2014 to 2023. We look for temporal, spatial, seasonal, and solar cycle patterns. We also discuss the percentage of occurrence of ionospheric irregularities and GNSS signal disturbances within the data at hand. We use in situ data collected by ESA-Swarm satellites and ground data provided by the Lantmäteriet-Swepos network ionosphere monitor. We find that high-latitude regions are susceptible to displaying more irregular electron density fluctuations (i.g., polar cap patches) than mid-latitudes. We also find that GNSS signal interference resulting in increased receivers’ positioning uncertainty is predominant at high latitudes. On the other hand, increased positioning uncertainty may be detected at noon in mid-latitude regions, mainly due to solar radiation exposure. Furthermore, hourly geomagnetic effects at high latitudes induce enhanced electron density fluctuations and positioning uncertainty at night. Findings also show more electron density fluctuations around winter and less in summer. Moreover, we find that the solar cycle influences the intensity of electron density fluctuations and positioning uncertainty, with the seasonal effects being more pronounced during periods of increased solar activity. Finally, results show that when ionospheric irregularities are observed, disturbances in GNSS signals may be detected, leading to imprecision in positioning services. Furthermore, we see that the absence of ionospheric irregularities results in a generally safe path for GNSS signals, which is beneficial for positioning accuracy. This comprehensive research enhances our understanding of ionospheric behavior in higher latitude environments and its impact on GNSS signals. Future research in this field could go deeper into the specific mechanisms driving electron density fluctuations and scintillation effects, explore additional geographic regions, and consider longer periods to refine our understanding of ionospheric dynamics and its implications for advanced space weather forecasting and satellite system resilience.

    Download full text (pdf)
    fulltext
  • Vayssiere, Christophe
    et al.
    Univ Toulouse III, Paule de Viguier Hosp, Dept Obstet Gynecol Reprod, CHU Toulouse, Toulouse, France..
    Yli, Branka
    Oslo Univ Hosp, Delivery Dept, Dept Delivery, Oslo, Norway..
    Ayres-de-Campos, Diogo
    Santa Maria Univ Hosp, Univ Lisbon, Med Sch, Lisbon, Portugal..
    Ugwumadu, Austin
    Univ London, St Georges Hosp, London, England..
    Loussert, Lola
    Univ Toulouse III, Paule de Viguier Hosp, Dept Obstet Gynecol Reprod, CHU Toulouse, Toulouse, France..
    Hellström-Westas, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Timonen, Susanna
    Turku Univ Hosp, Turku, Finland..
    Schwarz, Christiane
    Luebeck Univ, Lubeck, Germany..
    Nunes, Ines
    Univ Porto, Ctr Hosp Vila Nova de Gaia Espinho, CINTESIS Ctr Invest Tecnol & Serv Saude, Dept Obstet & Gynecol, Porto, Portugal..
    Roth, Georges-Emmanuel
    Univ Strasbourg, Dept Obstet & Gynecol, CHU Strasbourg, Strasbourg, France..
    EUROPEAN ASSOCIATION OF PERINATAL MEDICINE (EAPM) Position statement: Use of appropriate terminology for situations related to inadequate fetal oxygenation in labor2024In: European Journal of Obstetrics, Gynecology, and Reproductive Biology, ISSN 0301-2115, E-ISSN 1872-7654, Vol. 294, p. 55-57Article in journal (Refereed)
    Abstract [en]

    In high-resource countries, adverse perinatal outcomes are currently rare in term, non-malformed fetuses, undergoing labor, but they remain a leading cause of medico-legal dispute. Precise terminology is important to describe situations related to inadequate fetal oxygenation in labor, to ensure appropriate communication between healthcare professionals and adequate transmission of information to parents. This position statement provides consensus definitions from European perinatologists and midwives regarding the most appropriate terminology to describe situations related to inadequate fetal oxygenation in labor: suspected fetal hypoxia, severe newborn acidemia, newborn metabolic acidosis, and hypoxic-ischemic encephalopathy. It also identifies terms that are imprecise or nonspecific to this situation, and should therefore be avoided by healthcare professionals: fetal well-being, fetal stress, fetal distress, non-reassuring fetal state, and birth asphyxia.

    Download full text (pdf)
    fulltext
  • Kuboka, Maureen
    et al.
    Univ Nairobi, Coll Agr & Vet Sci, Dept Food Sci Nutr & Technol, POB 29053, Nairobi 00625, Kenya.;Int Livestock Res Inst, Dept Biosci, POB 30709, Nairobi 30709, Kenya..
    Njue, Lucy
    Univ Nairobi, Coll Agr & Vet Sci, Dept Food Sci Nutr & Technol, POB 29053, Nairobi 00625, Kenya..
    Mutua, Florence
    Int Livestock Res Inst, Dept Biosci, POB 30709, Nairobi 30709, Kenya..
    Grace, Delia
    Int Livestock Res Inst, Dept Biosci, POB 30709, Nairobi 30709, Kenya.;Univ Greenwich, Natl Resources Inst, Fac Engn & Sci, Gillingham ME4 4TB, Kent, England..
    Lindahl, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Int Livestock Res Inst, Dept Biosci, POB 30709, Nairobi 30709, Kenya.;Swedish Univ Agr Sci, Dept Clin Sci, POB 7054, SE-75007 Uppsala, Sweden..
    AFM1 Secretion and Efficacy of Novasil™ Clay in Kenyan Dairy Cows2022In: DAIRY, ISSN 2624-862X, Vol. 3, no 2, p. 220-232Article in journal (Refereed)
    Abstract [en]

    The occurrence of aflatoxin M1 (AFM1) in milk has been widely reported in Kenya, with levels freqently exceeding national and international thresholds. Exposure to aflatoxin increases the risk of hepatic cancers and can also have other negative health impacts in children such as growth impairment and immunosuppression. Anti-mycotoxin agents (AMAs) included in contaminated feeds can greatly reduce the amount of AFM1 released in milk. A 45-day trial was designed to assess secretion of AFM1 in milk from individual cows fed commercial Kenyan dairy feed, as well as the efficacy of Novasil (TM) Plus in reducing the levels. A four-by-four Latin square cross-over design was used for the experiment. Four cows were fed on naturally contaminated with AFB1 feed, with levels ranging from 19 to 47 mu g/kg, and either no binder or inclusion of binder at the rate of 0.6 or 1.2%. Milk samples were collected each day and analyzed for AFM1. The results showed that AFM1 levels in the milk varied between the cows, even when fed similar levels of contaminated feed. On average, inclusion of 0.6% binder into the diet resulted in 34% decline in milk AFM1 levels, while 1.2% binder dose resulted in a decline of 45%. Significant reduction in AFM1 secretion was observed in all experimental units (p < 0.005), though only minimal reduction was recorded in one of the units (Cow 4) compared to the other three. This trial shows novel data on aflatoxin exposure and excretion in Kenyan dairy cows in a field setting where AFB1 level is uncontrolled. We demonstrate significant reduction in AFM1 secretion in milk using AMA, though AFM1 levels were still above the recommended EC standard of 50 LATIN SMALL LETTER ENGg/kg. This study suggests that AMAs alone cannot be relied on to reduce AFM1 in milk to safe levels. Training and good feeding practices are recommended in addition to use of AMAs.

    Download full text (pdf)
    FULLTEXT01
  • Beckman, S
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Giertz, Tobias
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Högqvist Bandefur, Hampus
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Levin, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Ridderström, Linnéa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Rosenblad, Elsa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Single-cell proteomics in blood samples2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Single-cell proteomics is a useful tool for measuring differences in cell populations for clinical trials. In this report we have conducted a literary review where we looked at 23 different single-cell proteomics methods and their advantages and disadvantages. We have looked at both mass spectrometry-based and affinity-based methods to find upcoming methods in the field of single-cell proteomics. Our findings show that there are multiple promising techniques that can be applied in different contexts. Moreover, we recommended combining different protocols, for instance Capillary zone electrophoresis (CZE) with a microfluidic platform or Optidrop with one of the barcoding methods for better results. When conducting this review it became clear that most methods could be improved by implementing software programs such as PEPerMINT and Infinity flow. Therefore, we encourage that such data acquisition and analysis methods are implemented to yield more accurate characterization and quantification of the single-cell proteome.

    Download full text (pdf)
    Rapport
  • Lindén, Lovisa
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Strandberg, Hedvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Generation Greta: i gränslandet mellan hopp och förtvivlan: En kvalitativ intervjustudie om unga svenska kvinnors emotioner i relation tillklimatförändringar och framtiden2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    Linden_Strandberg_2024_fulltext
  • Hedbrant, Signe
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy.
    Att hjälpa eller inte hjälpa, det är frågan: Theron Pummers och Roger Crisps kritik av Fiona Woollards argument om vår moraliska förpliktelse i fall av välgörenhet2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    fulltext
  • Nyokabi, Ndungu S.
    et al.
    UCL, Inst Global Prosper, London, England..
    Korir, Lilian
    Univ Lincoln, Lincoln Inst Agrifood Technol, Lincoln, England..
    Lindahl, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Int Livestock Res Inst ILRI, POB 30709, Nairobi 00100, Kenya.;Swedish Univ Agr Sci, Dept Clin Sci, POB 7054, S-75007 Uppsala, Sweden..
    Phelan, Lisette
    Univ Leeds, Sch Geog, Leeds, England.;Wageningen Univ & Res, Dept Social Sci, Environm & Nat Resource Econ Grp, Wageningen, Netherlands..
    Gemechu, Gizachew
    Armauer Hansen Res Inst AHRI, Addis Ababa, Ethiopia..
    Berg, Stefan
    Bernhard Nocht Inst Trop Med, Hamburg, Germany..
    Mihret, Adane
    Armauer Hansen Res Inst AHRI, Addis Ababa, Ethiopia..
    Wood, James L. N.
    Univ Cambridge, Dept Vet Med, Cambridge, England..
    Moore, Henrietta L.
    UCL, Inst Global Prosper, London, England..
    Exploring the adoption of food safety measures in smallholder dairy systems in Ethiopia: implications for food safety and public health2024In: Food Security, ISSN 1876-4517, E-ISSN 1876-4525, Vol. 16, no 2, p. 423-435Article in journal (Refereed)
    Abstract [en]

    Milk is highly perishable and can be a conduit for the transmission of zoonotic foodborne pathogens. This cross-sectional survey involving 159 farming households and 18 participant observations in participating farms was undertaken in Addis Ababa and surrounding areas in Oromia, Ethiopia to assess the adoption of food safety measures in smallholder farms. Adoption of food safety measures at the farm level influences milk quality and safety across the entire milk value chain, from "grass to glass". This study considered the adoption of 36 different food safety measures (FSM) including animal health, milking hygiene, hygienic milk storage, and hygienic milking premises. A weighted food safety index (FSI, ranging from 0 to 100) was calculated for each household based on FSM adopted. Ordinary Least Squares linear regression was used to quantify the factors of FSM adoption by smallholder farmers. The overall food safety index ranged between 59.97-60.75. A majority of farmers may be classified as moderate adopters of FSM (index ranging between 30-70%). Farm and farmers' characteristics such as herd size, farmer's education level, farmer's expertise in dairying, and participation of the farm in the formal milk value- chain, were shown to positively influence the level of adoption of FSM. Low farm-level adoption of FSM has food safety and public health implications as it can lead to milk contamination and, therefore, expose consumers to foodborne diseases. There is an imperative for policymakers to design and implement policies and intervention strategies that lead to increased farmer training related to livestock production and awareness of the important role that FSM adoption can play in improving food safety and public health.

    Download full text (pdf)
    FULLTEXT01
  • Herraiz-Adillo, Angel
    et al.
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Ahlqvist, Viktor H.
    Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden..
    Higueras-Fresnillo, Sara
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Univ Autonoma Madrid, Dept Phys Educ Sport & Human Motr, Madrid, Spain..
    Hedman, Kristofer
    Linköping Univ, Dept Clin Physiol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Hagström, Emil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Smidt, Melony Fortuin- de
    Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden..
    Daka, Bledar
    Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden..
    Lenander, Cecilia
    Lund Univ, Ctr Primary Hlth Care Res, Dept Clin Sci Malmö, Lund, Sweden..
    Berglind, Daniel
    Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.;Ctr Epidemiol & Community Med, Reg Stockholm, Stockholm, Sweden..
    Ostgren, Carl Johan
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Ctr Med Image Sci & Visualizat CMIV, Linköping, Sweden..
    Radholm, Karin
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia..
    Ortega, Francisco B.
    Sport & Hlth Univ Res Inst iMUDS & CIBEROBN Physio, Univ Granada, Fac Sport Sci, Dept Phys Educ & Sports, Granada, Spain.;Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland..
    Henriksson, Pontus
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study2024In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 58, no 8Article in journal (Refereed)
    Abstract [en]

    Objectives To examine the associations between physical fitness in male adolescents and coronary and carotid atherosclerosis in middle age.Methods This population-based cohort study linked physical fitness data from the Swedish Military Conscription Register during adolescence to atherosclerosis data from the Swedish CArdioPulmonary bioImage Study in middle age. Cardiorespiratory fitness was assessed using a maximal cycle-ergometer test, and knee extension muscular strength was evaluated through an isometric dynamometer. Coronary atherosclerosis was evaluated via Coronary Computed Tomography Angiography (CCTA) stenosis and Coronary Artery Calcium (CAC) scores, while carotid plaques were evaluated by ultrasound. The associations were analysed using multinomial logistic regression, adjusted (marginal) prevalences and restricted cubic splines.Results The analysis included 8986 male adolescents (mean age 18.3 years) with a mean follow-up of 38.2 years. Physical fitness showed a reversed J-shaped association with CCTA stenosis and CAC, but no consistent association was observed for carotid plaques. After adjustments, compared with adolescents in the lowest tertile of cardiorespiratory fitness and muscular strength, those in the highest tertile had 22% (OR 0.78; 95% CI 0.61 to 0.99) and 26% (OR 0.74; 95% CI 0.58 to 0.93) lower ORs for severe (>= 50%) coronary stenosis, respectively. The highest physical fitness group (high cardiorespiratory fitness and muscular strength) had 33% (OR 0.67; 95% CI 0.52 to 0.87) lower OR for severe coronary stenosis compared with those with the lowest physical fitness.Conclusion This study supports that a combination of high cardiorespiratory fitness and high muscular strength in adolescence is associated with lower coronary atherosclerosis, particularly severe coronary stenosis, almost 40 years later.

    Download full text (pdf)
    FULLTEXT01
  • Gerger, Heike
    et al.
    Maastricht Univ, Care & Publ Hlth Res Inst, Dept Family Med, Maastricht, Netherlands.;Erasmus Univ, Dept Gen Practice, Med Ctr, Rotterdam, Netherlands.;Univ Basel, Dept Clin Psychol & Psychotherapy, Basel, Switzerland.;Maastricht Univ, Care & Publ Hlth Res Inst, Dept Family Med, P Debyepl 1, NL-6229 HA Maastricht, Netherlands..
    Munder, Thomas
    Univ Zurich, Dept Psychol, Zurich, Switzerland.;Univ Kassel, Dept Psychol, Kassel, Germany..
    Kreuzer, Nicole
    Univ Basel, Dept Clin Psychol & Psychotherapy, Basel, Switzerland..
    Locher, Cosima
    Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland..
    Blease, Charlotte
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group. Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Gen Med, Boston, MA USA..
    Lay Perspectives on Empathy in Patient-Physician Communication: An Online Experimental Study2024In: Health Communication, ISSN 1041-0236, E-ISSN 1532-7027, Vol. 39, no 6, p. 1246-1255Article in journal (Refereed)
    Abstract [en]

    Research indicates that patients consider empathy as a key factor contributing to the quality-of-care. However, ambiguities in the definition of this multidimensional construct complicate definite conclusions to-date. Addressing the challenges in the literature, and using a hypothetical physician-patient interaction which explored patient-perceived differences between expressions of affective empathy, cognitive empathy, compassion and no empathy, this study aimed to test whether lay participants' evaluations of the quality-of-care depend on the type of empathic physician behavior, and on the physician's gender. We conducted a randomized web-based experiment using a 4 (type of empathy) by 2 (physician gender) between-subjects design. Empathy was subdivided into three concepts: first, affective empathy (i.e. feeling with someone); second, cognitive empathy (i.e. understanding); and third, compassion (i.e. feeling for someone and offering support). Perceived quality-of-care was the primary outcome. Compared with non-empathic interactions, quality-of-care was rated higher when physicians reacted cognitively empathic or compassionate (d = 0.71; 0.43 to 1.00 and d = 0.68; 0.38 to 0.98). No significant difference was found between affective empathy and no empathy (d = 0.13; -0.14 to 0.42). The physician's gender was not related with quality-of-care. Aspects of participants' personality but not their age, gender or the number of physician visits were associated with quality-of-care. No interactions were observed. In showing that patients rated quality-of-care higher when physician reactions were described as cognitively empathic and compassionate, as compared with affectively empathic or non-empathic, our findings refine views about the kinds of empathy that are important in patient care with implications for clinical practice, education and communication trainings.

    Download full text (pdf)
    fulltext
  • Damgaard, Tobias
    et al.
    Linköping Univ, Pharmaceut Dept Kalmar, Linköping, Reg Kalmar Cty, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden..
    Woksepp, Hanna
    Linnaeus Univ, Dept Res, Kalmar, Sweden.;Linnaeus Univ, Dept Clin Microbiol Kalmar, Kalmar, Reg Kalmar Cty, Sweden.;Linnaeus Univ, Dept Chem & Biomed Sci, Kalmar, Sweden..
    Brudin, Lars
    Linköping Univ, Dept Clin Physiol Kalmar, Linköping, Reg Kalmar Cty, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Bonnedahl, Jonas
    Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Linköping Univ, Dept Infect Dis Kalmar, Linköping, Reg Kalmar Cty, Sweden..
    Nielsen, Elisabet I.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Schoen, Thomas
    Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Linköping Univ, Dept Infect Dis Kalmar, Dept Infect Dis Linköping, Linköping, Reg Kalmar Cty, Sweden..
    Haellgren, Anita
    Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Linköping Univ, Dept Infect Dis Linköping, Linköping, Sweden..
    Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units2024In: Infectious Diseases, ISSN 2374-4235, E-ISSN 2374-4243, Vol. 56, no 6, p. 451-459Article in journal (Refereed)
    Abstract [en]

    <bold>Background: </bold>Only about 50% of intensive care unit (ICU) patients reach a free trough concentration above MIC (100% fT > MIC) of beta-lactam antibiotics. Although dose adjustments based on therapeutic drug monitoring (TDM) could be beneficial, TDM is not widely available. We investigated serum creatinine-based estimated GFR (eGFR) as a rapid screening tool to identify ICU patients at risk of insufficient exposure. <bold>Method: </bold>Ninety-three adult patients admitted to four ICUs in southeast Sweden treated with piperacillin/tazobactam, meropenem, or cefotaxime were included. Beta-lactam trough concentrations were measured. The concentration target was set to 100% fT > MICECOFF (2, 4, and 16 mg/L based on calculated free levels for meropenem, cefotaxime, and piperacillin, respectively). eGFR was primarily determined via Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and compared to three other eGFR equations. Data was analysed using logistic regression and receiver operative characteristic (ROC) curves. <bold>Results: </bold>With intermittent standard dosing, insufficient exposure was common in patients with a relative eGFR >= 48mL/min/1.73m(2) [85%, (45/53)], particularly when treated with cefotaxime [96%, (24/25)]. This eGFR cut-off had a sensitivity of 92% and specificity of 82% (AUC 0.871, p < 0.001) in identifying insufficient exposure. In contrast, patients with eGFR <48mL/min/1.73m(2) had high target attainment [90%, (36/40)] with a wide variability in drug exposure. There was no difference between the four eGFR equations (AUC 0.866-0.872, cut-offs 44-51 ml/min/1.73m(2)). <bold>Conclusion: </bold>Serum creatinine-based eGFR is a simple and widely available surrogate marker with potential for early identification of ICU patients at risk of insufficient exposure to piperacillin, meropenem, and cefotaxime.

    Download full text (pdf)
    fulltext
  • Wu, Jingnan
    et al.
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.;Aalborg Univ, Dept Chem & Biosci, DK-9220 Aalborg, Denmark..
    Ling, Zhaoheng
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Franco, Leandro R. R.
    Karlstad Univ, Dept Engn & Phys, S-65188 Karlstad, Sweden..
    Jeong, Sang Young
    Korea Univ, Dept Chem, Seoul 02841, South Korea..
    Genene, Zewdneh
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden..
    Mena, Josue
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden..
    Chen, Si
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Chen, Cailing
    King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia..
    Araujo, Moyses
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Karlstad Univ, Dept Engn & Phys, S-65188 Karlstad, Sweden..
    Marchiori, Cleber F. N.
    Karlstad Univ, Dept Engn & Phys, S-65188 Karlstad, Sweden..
    Kimpel, Joost
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden..
    Chang, Xiaoming
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Isikgor, Furkan H. H.
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Chen, Qiaonan
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden..
    Faber, Hendrik
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Han, Yu
    King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia..
    Laquai, Frederic
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Zhang, Maojie
    Shandong Univ, Natl Engn Res Ctr Colloidal Mat, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China..
    Woo, Han Young
    Korea Univ, Dept Chem, Seoul 02841, South Korea..
    Yu, Donghong
    Aalborg Univ, Dept Chem & Biosci, DK-9220 Aalborg, Denmark..
    Anthopoulos, Thomas D. D.
    King Abdullah Univ Sci & Technol KAUST, KAUST Solar Ctr, Thuwal 23955, Saudi Arabia..
    Wang, Ergang
    Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden..
    On the Conformation of Dimeric Acceptors and Their Polymer Solar Cells with Efficiency over 18 %2023In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 62, no 45Article in journal (Refereed)
    Abstract [en]

    The determination of molecular conformations of oligomeric acceptors (OAs) and their impact on molecular packing are crucial for understanding the photovoltaic performance of their resulting polymer solar cells (PSCs) but have not been well studied yet. Herein, we synthesized two dimeric acceptor materials, DIBP3F-Se and DIBP3F-S, which bridged two segments of Y6-derivatives by selenophene and thiophene, respectively. Theoretical simulation and experimental 1D and 2D NMR spectroscopic studies prove that both dimers exhibit O-shaped conformations other than S- or U-shaped counter-ones. Notably, this O-shaped conformation is likely governed by a distinctive "conformational lock" mechanism, arising from the intensified intramolecular & pi;-& pi; interactions among their two terminal groups within the dimers. PSCs based on DIBP3F-Se deliver a maximum efficiency of 18.09 %, outperforming DIBP3F-S-based cells (16.11 %) and ranking among the highest efficiencies for OA-based PSCs. This work demonstrates a facile method to obtain OA conformations and highlights the potential of dimeric acceptors for high-performance PSCs.

    Download full text (pdf)
    fulltext
  • Regnström, Gabriella
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature and Rhetoric.
    Från boksidor till bildrutor: En adaptionsstudie av narratologiska förändringar i Octavia E. Butlers roman Tidens länkar2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The study examines how narrative aspects change when a story is adapted from one medium to another, focusing on Octavia E. Butler's novel "Kindred" and the graphic novel "Kindred: A Graphic Novel Adaptation" by Damian Duffy and John Jennings. The analysis compares these works based on four aspects: plot, time, narrator, and theme. The results show both similarities and differences between the novel and the graphic novel. While most of the central events in the plot were retained during the adaptation, there are significant differences in the handling of time and narrator, likely due to the requirements of the new medium. The theme shows similar patterns, where differences can be attributed to both the medium and the storyline.

    Furthermore, the study discusses how these adaptations can be used in education. By analyzing both the novel and the graphic novel, teachers can help students understand how different media-specific narrative elements are used to convey the same story in different ways. This can also contribute to including visual literacy in education, which is important for students' reading skills in today's media landscape.

    Download full text (pdf)
    fulltext
  • Staal, Laura
    et al.
    Univ Groningen, Groningen Inst Evolutionary Life Sci, Neurobiol, NL-9700 CC Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 GZ Groningen, Netherlands..
    Plosch, Torsten
    Departments of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands;Perinatal Neurobiology, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
    Kunovac Kallak, Theodora
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Reproductive Health.
    Sundström Poromaa, Inger
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Reproductive Health.
    Wertheim, Bregje
    Univ Groningen, Groningen Inst Evolutionary Life Sci, Evolutionary Genet, Dev & Behav, NL-9700 CC Groningen, Netherlands..
    Olivier, Jocelien D. A.
    Univ Groningen, Groningen Inst Evolutionary Life Sci, Neurobiol, NL-9700 CC Groningen, Netherlands..
    Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor2024In: ACS Chemical Neuroscience, E-ISSN 1948-7193, Vol. 15, no 6, p. 1074-1083Article in journal (Refereed)
    Abstract [en]

    About 5% of pregnant women are treated with selective serotonin reuptake inhibitor (SSRI) antidepressants to treat their depression. SSRIs influence serotonin levels, a key factor in neural embryonic development, and their use during pregnancy has been associated with adverse effects on the developing embryo. However, the role of the placenta in transmitting these negative effects is not well understood. In this study, we aim to elucidate how disturbances in the maternal serotonergic system affect the villous tissue of the placenta by assessing whole transcriptomes in the placentas of women with healthy pregnancies and women with depression and treated with the SSRI fluoxetine during pregnancy. Twelve placentas of the Biology, Affect, Stress, Imaging and Cognition in Pregnancy and the Puerperium (BASIC) project were selected for RNA sequencing to examine differentially expressed genes: six male infants and six female infants, equally distributed over women treated with SSRI and without SSRI treatment. Our results show that more genes in the placenta of male infants show changed expression associated with fluoxetine treatment than in placentas of female infants, stressing the importance of sex-specific analyses. In addition, we identified genes related to extracellular matrix organization to be significantly enriched in placentas of male infants born to women treated with fluoxetine. It remains to be established whether the differentially expressed genes that we found to be associated with SSRI treatment are the result of the SSRI treatment itself, the underlying depression, or a combination of the two.

    Download full text (pdf)
    fulltext
  • Freedman, Victor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Chemical and Bio-Molecular Physics. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Determining neighbouring aminoacids impact on protein sequencing with nanopores using Molecular Dynamics2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    One focus goal that science always works towards is an understanding of biological structures, with proteins being one of the main research goals. Sequencing proteins is currently a time-exhausting task, so focus is being put on trying to use nanopores in a similar way as in DNA sequencing for proteins. In this report, the neighbouring amino acids in the same peptide as the amino acid being sequenced are varied and the change in ionic current from the pore based on the neighbouring amino acids is analysed. This was done by using Molecular Dynamics program NAMD. A peptide was placed in the center of different silicon nitride pore structures inside a water box with ions and was simulated with an added electric field. The drop in current was checked for 4 different peptide systems and one check for the empty pores. The results presented in the report show that changing the neighbouring amino acids increases the current measured, therefore making the current blocking worse when mixing nearby amino acids. However, the differences are very small and similar amino acids give wildly different values. A larger evaluation with more computational power seems reasonable for a more definitive result.

    Download full text (pdf)
    fulltext
  • Huang, Liping
    et al.
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Li, Qiang
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Wu, Jason H. Y.
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Sch Populat Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Tian, Maoyi
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Harbin Med Univ, Sch Publ Hlth, Harbin, Peoples R China..
    Yin, Xuejun
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing, Peoples R China..
    Yu, Jie
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Liu, Yishu
    Nanjing Med Univ, Sch Publ Hlth, Nanjing, Peoples R China..
    Zhang, Xinyi
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Wu, Yangfeng
    Peking Univ, Clin Res Inst, Beijing, Peoples R China.;Peking Univ, Sch Publ Hlth, Beijing, Peoples R China..
    Paige, Ellie
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Trieu, Kathy
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Marklund, Matti
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism. George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA..
    Rodgers, Anthony
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia..
    Neal, Bruce
    George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Imperial Coll London, London, England..
    The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study2024In: Journal of Human Hypertension, ISSN 0950-9240, E-ISSN 1476-5527, Vol. 38, no 4, p. 298-306Article in journal (Refereed)
    Abstract [en]

    The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP. We then fitted a series of models to estimate the SBP reductions expected for the differences in sodium and potassium intake in SSaSS, derived from 24-h urine collections. The proportions of the SBP reduction separately attributable to sodium reduction and potassium supplementation were calculated. The observed SBP reduction in SSaSS was -3.3 mmHg with a corresponding mean 15.2 mmol reduction in 24-h sodium excretion and a mean 20.6 mmol increase in 24-h potassium excretion. Assuming 90% of dietary sodium intake and 70% of dietary potassium intake were excreted through urine, the models projected falls in SBP of between -1.67 (95% confidence interval: -4.06 to +0.73) mmHg and -5.33 (95% confidence interval: -8.58 to -2.08) mmHg. The estimated proportional contribution of sodium reduction to the SBP fall ranged between 12 and 39% for the different models fitted. Sensitivity analyses assuming different proportional urinary excretion of dietary sodium and potassium intake showed similar results. In every model, the majority of the SBP lowering effect in SSaSS was estimated to be attributable to the increase in dietary potassium rather than the fall in dietary sodium.

    Download full text (pdf)
    FULLTEXT01
  • El-Seedi, Hesham R.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.;Jiangsu Educ Dept, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Zhenjiang 212013, Jiangsu, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt..
    Khalifa, Shaden A. M.
    Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden..
    Mohamed, Azza H.
    Menoufia Univ, Fac Sci, Dept Zool, Div Parasitol, Shibin Al Kawm 32512, Egypt..
    Yosri, Nermeen
    Beni Suef Univ, Res Inst Med & Aromat Plants RIMAP, Chem Dept Med & Aromat Plants, Bani Suwayf 62514, Egypt.;Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China..
    Zhao, Chao
    Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Peoples R China..
    El-Wakeil, Nabil
    Natl Res Ctr, Pests & Plant Protect Dept, Cairo, Egypt.;King Faisal Univ, Coll Agri & Food Sci, Dept Arid Land Agr, POB 55073, Al Hufuf 31982, Saudi Arabia..
    Attia, Nour F.
    Natl Inst Stand, Chem Div, Gas Anal & Fire Safety Lab, Giza 12211, Egypt..
    Xu, Baojun
    BNU HKBU United Int Coll, Programme Food Sci & Technol, Zhuhai, Peoples R China..
    AbdElhafez, AbdElhafez R.
    Menoufia Univ, Fac Sci, Zool Dept, Shibin Al Kawm 32512, Egypt..
    Boskabady, Mohammad H.
    Sch Med, Deartment Physiol, Mashhad 9177948564, Razavi Khorasan, Iran..
    Elseedy, Sherif
    Ain Shams Univ, Fac Med, Cairo 11591, Egypt..
    Efferth, Thomas
    Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany..
    Verpoorte, Rob
    Leiden Univ, Inst Biol, Nat Prod Lab, Box 955, NL-2300 RA Leiden, Netherlands..
    Plant extracts and compounds for combating schistosomiasis2023In: Phytochemistry Reviews, ISSN 1568-7767, E-ISSN 1572-980X, Vol. 22, no 6, p. 1691-1806Article in journal (Refereed)
    Abstract [en]

    Schistosomiasis is a vector-borne water-based disease caused by Schistosoma blood flukes. It mostly affects people in low-income regions, 90% of reported cases being in developing countries. Schistosoma has a complex lifecycle, alternately infecting mammalian hosts and snails. The snails hosting the parasite are the most viable targets. Selective preparations for reducing the parasite pool in snails and infected water are required as current molluscicides are also nontoxic to other organisms, including fish, and thus affect food supplies in infected areas. Plants (e.g. Annona crassiflora Mart., A. muricata L., and A. montana Macfad.) are attractive potential sources as alternative molluscicides and novel entity to treat the disease owned to their diverse biologically potent compounds including; saponins, alkaloids, terpenoids, and tannins. Additionally, they can be locally cultivated, providing income for farmers and reducing treatment costs. Here, we review plants, plant extracts and isolated compounds that have shown activities against the host snails or Schistosoma in various parts of its life cycle. Plants have a lot of potential and will continue to contribute feasible, effective medicines and/or pesticides; more research is warranted to fully explore their future applications.

    Download full text (pdf)
    FULLTEXT01
  • Siljeholm, Ola
    et al.
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Region Stockhol, Sweden.;Stockholm Hlth Care Serv, Stockholm, Region Stockhol, Sweden.;Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Riddargatan 1, SE-11435 Stockholm, Region Stockhol, Sweden.;Stockholm HealthCare Serv, Riddargatan 1, SE-11435 Stockholm, Region Stockhol, Sweden..
    Edvardsson, Kerstin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social medicine/CHAP.
    Bergstroem, Malin
    Stockholm Univ, Karolinska Inst, Ctr Hlth Equ Studies CHESS, Stockholm, Sweden.;Karolinska Inst, Dept Med, Clin Epidemiol, Stockholm, Sweden..
    Hammarberg, Anders
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Region Stockhol, Sweden.;Stockholm Hlth Care Serv, Stockholm, Region Stockhol, Sweden..
    Community Reinforcement and Family Training versus counselling for parents of treatment-refusing young adults with hazardous substance use: A randomized controlled trial2024In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 119, no 5, p. 915-927Article in journal (Refereed)
    Abstract [en]

    Background and aimsDespite the high prevalence and negative effects of hazardous substance use, few young adults enter treatment. Community Reinforcement and Family Training (CRAFT), a support programme for concerned significant others of people with substance use disorders, has proved efficacious in promoting treatment entry. The aim of the current trial was to compare the efficacy of CRAFT with an active control for parents of young adults (aged 18-24 years) with hazardous substance use.DesignThis was a randomized controlled superiority trial comparing CRAFT (n = 58) with an active control group receiving manualized counselling (n = 55), with outcome assessments at 6, 12 and 24 weeks (primary end-point). A sequential design with a stopping rule was added post recruitment commencement.SettingThe study took place in two outpatient clinics for young adults in Stockholm, Sweden, and subsequently via video-conference due to COVID-19.ParticipantsBetween October 2018 and May 2021, 113 participants (92% female) who were parents of young adults (87% male) were recruited. Recruitment was discontinued when 70% of the planned sample had been recruited, following an interim analysis of the primary outcome showing no difference between conditions.Intervention and comparatorParticipants were randomized (ratio 1 : 1) to eight manual-based individual CRAFT sessions or five individual manual-based counselling sessions + one voluntary psychoeducative group session, delivered over maximum 14 weeks.MeasurementsThe primary outcome measure was the rate of young adult entry in substance use treatment during the trial period (24 weeks).FindingsAt the 24 weeks follow-up, 19 (33%) of CRAFT participants and 17 (31%) of counselling participants had reported young adult treatment entry, with no difference between conditions (odds ratio CRAFT versus counselling 0.84, 95% confidence interval = 0.35; 1.99, P = 0.700). Both conditions reported clinically relevant reductions in young adult substance use, but no change in participants' levels of depression, anxiety or stress.ConclusionsThis trial showed no statistically significant evidence that Community Reinforcement and Family Training (CRAFT), a support programme for concerned significant others of people with substance use disorders, is more efficacious than manual-based counselling regarding treatment entry for young adults.

    Download full text (pdf)
    fulltext
  • Larsson Ljungström, Daniel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History, Conservation.
    Ålfiske, ett utrotningshotat kulturarv: Bevarandet av ett immateriellt kulturarv2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This work studies whether it is possible to safeguard the intangible cultural heritage Ålarvet på Ålakusten (The Eel heritage on the Eel-coast) with UNESCO's Convention for the safeguarding of the intangible cultural heritage. The work has established what Ålarvet på Ålakusten consists of and what threats there are against the cultural heritage. The survey also aims to contribute to the documentation of eel fishing on the Eel-coast. To investigate this, a literature survey has been carried out together with four interviews. Two with eel fishermen, one with an advisor at ISOF and the last with a member of the Eel-coasts cultural heritage association.

    The results were that Ålarvet på Ålakusten consists of various tangible and intangible cultural heritage involving knowledge and skills: huts, boats, boat building, eel fishing, eel festivals, stories, traditions and cooking.

    The threats to eel fishing are based on the drastic decline since the 1950s. The reasons for the decline are: migration obstacles, trenching, hydroelectric plants, fishing, predators, pollution and climate change. Eel fishing bans are the biggest threat to the cultural heritage being passed on to the next generation.

    The result shows that UNESCO's convention does not provide real protection for the intangible cultural heritage as the convention is subject to the member state's laws. However, the convention gives attention to the cultural heritage as long as it is still practiced. It is up to the practitioners themselves to protect and preserve the intangible cultural heritage.

    Download full text (pdf)
    fulltext
  • Peleli, Maria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.;Natl & Kapodistrian Univ Athens, Dept Pharm, Lab Pharmacol, Athens, Greece.;Acad Athens, Clin Expt Surg & Translat Res Ctr, Biomed Res Fdn, Athens, Greece..
    Lyngso, Kristina S.
    Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark..
    Poulsen, Frantz Rom
    Odense Univ Hosp, Dept Neurosurg, Odense, Denmark.;Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;BRIDGE Brain Res Interdisciplinary Guided Excellen, Odense, Denmark.;OPEN Odense Patient Data Explorat Network, Odense, Denmark..
    Hansen, Pernille B. L.
    Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark..
    Papapetropoulos, Andreas
    Natl & Kapodistrian Univ Athens, Dept Pharm, Lab Pharmacol, Athens, Greece.;Acad Athens, Clin Expt Surg & Translat Res Ctr, Biomed Res Fdn, Athens, Greece..
    Stubbe, Jane
    Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.;Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, JB Winslows Vej 21,3rd floor, DK-5000 Odense C, Denmark..
    Inhibition of cystathionine-gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles2023In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 239, no 1Article in journal (Refereed)
    Abstract [en]

    AimIn extracerebral vascular beds cystathionine-gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles. MethodsIntracerebral arterioles were isolated from wild type C57BL/6J mouse (9-12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set-up. Reverse transcription polymerase chain reaction was used for detecting CSE expression. ResultsCSE is expressed in human and mouse intracerebral arterioles. CSE inhibition with L-propargylglycine (PAG) significantly dampened the K+-induced vasoconstriction in intracerebral arterioles of both species (% of maximum contraction: in human control: 45.4 & PLUSMN; 2.7 versus PAG: 27 & PLUSMN; 5.2 and in mouse control: 50 & PLUSMN; 1.5 versus PAG: 33 & PLUSMN; 5.2) but did not affect the secondary dilatation. This effect of PAG was significantly reversed by the H2S donor sodium hydrosulfide (NaSH) in human (PAG + NaSH: 38.8 & PLUSMN; 7.2) and mouse (PAG + NaSH: 41.7 & PLUSMN; 3.1) arterioles, respectively. The endothelial NO synthase (eNOS) inhibitor, N & omega;-Nitro-l-arginine methyl ester (L-NAME), and the inhibitor of soluble guanylate cyclase (sGC), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) reversed the effect of PAG on the K+-induced vasoconstriction in the mouse arterioles and attenuated the K+-induced secondary dilatation significantly. ConclusionCSE contributes to the K+-induced vasoconstriction via a mechanism involving H2S, eNOS, and sGC whereas the secondary dilatation is regulated by eNOS and sGC but not by CSE.

    Download full text (pdf)
    fulltext
  • Thylwe, Stina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Bertha Mathilda, Edla och 101 andra kvinnor: Levnadsomständigheter för kvinnorna vars namn finns bevarade i arkiven efter reglementeringen av prostitutionen i 1880-talets Uppsala2024Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis, the regulation of prostitution in Uppsala during the 1880’s is investigated with the aim of finding out more about the living circumstances of the women who were considered or suspected of being licentious or prostitutes. The theoretical framework drawn upon for analyzing and understanding the living circumstances of these women is Carole Pateman’s The Sexual Contract. The paper consists of three parts: first, an overview of the source material. Second, a collective biography of 103 women who had notes made about them during the 1880’s. Third, a case study where five women were followed from the cradle to the grave. 

    What was discovered was that the archives from this period in Uppsala are inconsistent and difficult to understand. Many of the women who had their names recorded in the source material were not prostitutes but rather women who in some way or another got caught by the authorities for perceived suspicious behaviour. Some underwent gynaecological examination and were never mentioned again. Others remained under the control of the authorities for decades, even when they were no longer regarded as being prostitutes. The conclusion is that, despite many of these women sharing similar backgrounds, their living circumstances both before and after their time being under the eyes of the authorities varied. This sheds a new and nuanced light both on earlier research about women regulated in prostitution during this time, how the authorities in Uppsala were administering women that were deviating from the norm, and how these women were perceived by contemporary society. 

    Download full text (pdf)
    fulltext
  • Harcke, Katri
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.;Acad Primary Hlth Care Ctr, Stockholm, Sweden..
    Lindunger, Anders
    Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Publ Dent Serv Södertälje, Stockholm, Sweden..
    Kollinius, Erik
    Publ Dent Serv Södertälje, Stockholm, Sweden..
    Gebreslassie, Mihretab
    Ctr Epidemiol & Community Med, Stockholm, Sweden..
    Morawski, Anna Ugarph
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.;Acad Primary Hlth Care Ctr, Stockholm, Sweden..
    Nylen, Charlotta
    Acad Primary Hlth Care Ctr, Stockholm, Sweden.;Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden..
    Peterson, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Acad Primary Hlth Care, Uppsala, Sweden..
    Yucel-Lindberg, Tuelay
    Karolinska Inst, Dept Dent Med, Huddinge, Sweden..
    Ostenson, Claes-Goran
    Karolinska Inst, Dept Mol Med & Surg, Endocrine & Diabet Unit, Karolinska Univ Hosp, Solna, Sweden..
    Skott, Pia
    Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Publ Dent Serv Södertälje, Stockholm, Sweden..
    Stattin, Nouha Saleh
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.;Acad Primary Hlth Care Ctr, Stockholm, Sweden..
    Observational study of selective screening for prediabetes and diabetes in a real-world setting: an interprofessional collaboration method between public dental services and primary health care in Sweden2024In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 42, no 1, p. 170-177Article in journal (Refereed)
    Abstract [en]

    Objective: Describe a method in a real-world setting to identify persons with undiagnosed prediabetes and type 2 diabetes through an interprofessional collaboration between Public Dental Services and Primary Health Care in Regions Stockholm.

    Design: A descriptive observational study.

    Setting: The study was conducted at seven sites in the region of Stockholm, Sweden. Each collaborating site consisted of a primary health clinic and dental clinic.

    Subjects: Study participants included adults over 18 years of age who visited the Public Dental Services and did not have a medical history of prediabetes or type 2 diabetes.

    Main outcome measures: Selective screening is conducted in accordance with a risk assessment protocol at the Public Dental Services. In the investigated method, DentDi (Dental and Diabetes), adults diagnosed with caries and/or periodontitis over a cut-off value are referred to the Primary Health Care clinic for screening of prediabetes and type 2 diabetes.

    Results: DentDi, introduced at seven sites, between the years 2017 and 2020, all of which continue to use the method today. A total of 863 participants from the Public Dental Services were referred to the Primary Health Care. Of those 396 accepted the invitation to undergo screening at the primary health care centre. Twenty-four individuals did not meet the inclusion criteria, resulting in a total of 372 persons being included in the study. Among the 372 participants, 27% (101) had elevated glucose levels, of which 12 were diagnosed with type 2 diabetes and 89 with prediabetes according to the study classification.

    Conclusions: DentDi is a feasible method of interprofessional collaboration where each profession contributes with the competence included in everyday clinical practice for early identification of persons with prediabetes and type 2 diabetes with a complete chain of care. The goal is to disseminate this method throughout Stockholm County and even other regions in Sweden.

    Download full text (pdf)
    fulltext
  • Ezra, Johanna
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Solar Cell Technology.
    Beck-Norén, Filippa
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Solar Cell Technology.
    Byggnadsintegrerade solceller:utmaningar och möjligheter för enhållbar framtid: En studie av hur byggnadsintegrerade solceller presterarjämfört med marknadsledande applicerade solceller2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis aims to compare the performance of building integrated PV to “market leading” building applied PV and determine which technology is the most profitable. A case study is conducted of the real estate company Vasakronan’s two buildings Magasin X and Celsius which have both building-integrated PV in the facade and building-applied PV on the roof. The power output from the building-integrated PV systems compared to the building-applied PV systems is studied for each of the four seasons of the year. The system design including technical specifications for the modules and inverters as well as relevant weather data for Uppsala was implemented in the simulation software SAM. By simulating the PV systems in SAM an expected power profile is generated which in comparison with the actual power output from the PV systems could indicate if they are performing optimally. A Life Cycle costing (LCC) analysis is performed to give an understanding of the economic profitability of the different technologies over time. To include the perspective of the challenges in expanding the market for building integrated PV in Sweden, two interviews are conducted. 

    The results show that the BIPV generates more energy than the BAPV per square meter during the winter. During the spring and autumn, the weather conditions have a great impact on the perfor- mance of the solar modules. During sunny days of spring the temperature of the modules increase which decrease their efficiency and hence the generated power. The results also indicate that the actual power output from both the BIPV and the BAPV overall are performing as expected from the theoretically generated power in SAM. There are cases where the facade-integrated photovoltaics exceed its theoretical power output values. In contrast, roof-applied photovoltaics exhibit a closer correlation with theoretical values, although with a tendency to underperform overall.The life cycle cost analysis indicates that for both buildings, Magasin X and Celsius, only the BAPV system is profitable. In contrast, the BIPV installation is not cost-effective without subsidies. However, as shown in the sensitivity analysis, the electricity price is a factor which has a large impact on the profitability of the system. With a doubled electricity price the entire solar cell installation of Mag- asin X has a pay-back time of 10.6 years and is considered profitable. It can also be concluded that there is a lack of knowledge of how to implement BIPV in the most efficient way as well as what amount of energy the BIPV systems are expected to generate. To expand the BIPV market, stakeholders need to share their knowledge and a standardized process will need to be developed for choosing BIPV for new buildings. Subventions can motivate companies to implement BIPV in practice which is crucial for the spreading of such knowledge and the future development of BIPV. 

    Download full text (pdf)
    fulltext
  • Cekol, Ana
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    The role of type VI secretion systems in the competitive ability of Escherichia coli strain D122024Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Download full text (pdf)
    fulltext
  • Dahlberg, Marie
    et al.
    Luckhaus, Jamie Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group.
    Hasson, Henna
    Jansson, Hanna
    Lek, Madelen
    Savage, Carl
    Riggare, Sara
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Disability Research.
    Wannheden, Carolina
    Why publish?: An interview study exploring patient innovators’ reasons for and experiences of scientific publishing2024In: Research Involvement and Engagement, E-ISSN 2056-7529, Vol. 10, no 1, article id 54Article in journal (Refereed)
    Abstract [en]

    Background: Scientific publications featuring patient-driven innovations (i.e., innovations that are developed and driven by patients or informal caregivers) are increasing. By understanding patient innovators' experiences of research publication, the scientific community may be better prepared to support or partner with patient innovators. Thus, the aim of this study was to explore patient innovators' reasons for and experiences of authoring scientific publications about their innovations.

    Methods: Qualitative semi-structured interviews were conducted with 15 international patient innovators from three continents who had published in scientific journals. Participants were identified through a scoping review on patient-driven innovations and snowball sampling. Interviews were conducted from June to October 2022 and the data was analyzed using the Framework Method.

    Findings: Participants' reasons for publishing in scientific journals were to strengthen the roles and voices of patients and informal caregivers, and to get recognition for their innovations. Some published as a response to serendipitous opportunities. Several positive experiences were reported: collaborations defined by transparency, mutual respect, and meaningful participation; learning and competence development; and gained confidence regarding the value of lived experiences in research. Participants also reported negative experiences, such as cultural barriers manifested as conservatism in academia and power imbalances between participants and researchers, and structural barriers regarding academic affiliations and research funding.

    Conclusions: Despite progress in increasing patient and public involvement in research and publication, our study found that patient innovators still experience barriers. This suggests that continued efforts are needed to facilitate contributions from patient innovators and other public actors to the production of relevant and meaningful research.

    Download full text (pdf)
    fulltext
  • Törnberg Goldring, Christian
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Tiden mellan häll och borg: En datering av fornborgar i Västmanland med hjälp av hällristningar och forna strandlinjer2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    There are two main areas of rock art in Västmanland county with a close relation to the ancient shorelines. In both areas, there are hillforts that have not yet been dated. The aim is to date Näsborgen and Kastena Skans in eastern and western Västmanland by using the geographic information system QGIS and ancient shoreline data obtained from Geological Survey of Sweden (SGU). Additionally, the hillforts are considered from a landscape perspective and their relation to rock art sites and heaps of fire-cracked stones, which support Bronze Age datings for these hillforts. The analysis uses previously confirmed Bronze Age datings of three hillforts in Uppland as a reference for the hillforts in Västmanland and provides an overview of other nearby hillforts. Both Näsborgen and Kastena Skans are determined to have been constructed during the Bronze Age.

    Download full text (pdf)
    fulltext
  • Löfström Renman, Agnes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. UU.
    Comparative analysis of Hemoglobin A1c on QuikRead Go and DCA Vantage against Cobas Pro reference method: A verification study2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Diabetes is a significant health burden worldwide. The most common types of diabetes, type 1 and type 2 diabetes are typically characterized by complete insulin deficiency and varying degrees of insulin deficiency, respectively. Glycated hemoglobin (HbA1c), formed when hemoglobin and glucose combine through glycation, can be used to monitor treatment in diabetic patients, and thus prevent future complications of the disease. HbA1c can be measured using point-of-care (POC) instruments, providing rapid results and immediate feedback on HbA1c levels. Measurement with POC instruments can reduce the need for additional visits for blood sampling, thereby lowering costs for both patients and healthcare systems. The main purpose of this study was to verify HbA1c on the POC instruments QuikRead Go and DCA Vantage by comparing the results with the reference method Cobas Pro and by comparing capillary and venous blood samples. The study utilized 30 venous patient samples, including 20 samples already analyzed on Cobas Pro and 10 samples collected venously and capillary from volunteer individuals. The coefficient of variation (CV) for QuikRead Go fell within the quality goal, while DCA Vantage exceeded the goal. The results demonstrated good agreement between capillary blood samples analyzed on POC instruments and venous samples analyzed on Cobas Pro. However, a statistically significant difference was found comparing venous samples analyzed on POC instruments and Cobas Pro. The results suggest that capillary sampling should be used for analysis on POC instruments. Certain limitations of the study should be considered when using QuikRead Go and DCA Vantage in practice. 

    Download full text (pdf)
    fulltext
  • Legnér, Mattias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History, Conservation.
    Uses and abuses of heritage in Scandinavia: The Second World War2024Conference paper (Other academic)
    Download full text (pdf)
    fulltext
  • Maathz, Felix
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Från plastkort till pixlar: Svenska statens syn på utvecklingen av e-legitimation2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Under 2000-talet har digitaliseringen blivit alltmer påtaglig i samhället och befolkningen började i högre utsträckning använda de e-tjänster som erbjöds. E-legitimation blev ett exempel på vad nya teknologiska framsteg kan erbjuda allmänheten. Denna utveckling blev för många revolutionerande, men väckte samtidigt frågor kring vilka samhällsgrupper som blivit inkluderade i utvecklingen av teknologin. Denna uppsats undersöker synen staten haft på e-legitimationens roll i samhället genom att analysera vilka problem som identifieras, vilka samhällsgrupper som ansetts vara exkluderade och hur framtidsvisioner förmedlats i statliga utredningar av 24-timmarsdelegationen, E-delegationen och i Betalningsutredningen. Undersökningen visar att äldre, låginkomsttagare, personer med utländsk bakgrund och personer med funktionshinder har identifierats som exkluderade i statliga utredningar under utvecklingen av e-legitimation i Sverige vilket påverkat deras möjlighet att delta i den digitala utvecklingen. Genom att belysa dessa aspekter av e-legitimationens utveckling bidrar uppsatsen till ytterligare förståelse för hur teknologiska framsteg kan leda till exkludering av samhällsgrupper, och hur statens synsätt på teknologi påverkar detta. 

    Download full text (pdf)
    fulltext
  • Hedin Käck, Mimmi
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    To bury a child: A spatial analysis of child burials at Giza and Saqqara2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates if there is any age segmentation among child burials. This is done through a spatial analysis, to better understand children in a mortuary space. The two cemeteries that will be investigated are the Wall of the Crow in Late Period Giza and the so-called Upper Necropolis in Saqqara during the Ptolemaic Period. The study includes 83 child burials from Saqqara and 73 child burials from Giza, of newborns to children of 14 years of age. This is achieved by deconstructing the data available to clarify the bond that exists and/or does not exist between the burials. In addition, child mortality and burial customs will be discussed to better understand burial rates in comparison to mortality rates. Finally, to understand properly the cemetery space, and children as a sub-set in it, the wider constructed landscapes are considered. The outcome of this thesis was that no cemetery had any age segmentation.

    Download full text (pdf)
    fulltext
  • Tudor, Matilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    A queer kind of dwelling: Digital throwness and existential security among sexual minorities in Russia2022In: New Media and Society, ISSN 1461-4448, E-ISSN 1461-7315, Vol. 26, no 7, p. 3895-3911Article in journal (Refereed)
    Abstract [en]

    This article asks what it means to habituate a queer orientation in a world permeated by digital connectivity. In doing so, it takes media phenomenology away from the mundane towards the momentous, drawing on queer phenomenology, and existential media studies. Using life-narrative interviews with sexual minorities in Russia, the article sheds light on the “work of queer habituation” in a straight world, and the contemporary significance of digital media technologies within this process. Digital media’s ability to multiply space is defined a key feature which offers sites to “stay with” the disorienting experience of queer dispositions. Through longer periods of discrete “queer digital dwelling,” individuals who have been associating their queer desires with ontological threats are able to find space for existence and existential security. By locating others in close proximity, some are also allowed to appropriate local territory in ways that make it more livable.

    Download full text (pdf)
    fulltext
  • Bogen, Vera
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Borgarna vid vattnets kant: En landskapsanalys av Ölands ringborgar och relationen till vatten2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study examines the placement of Öland's ringforts in relation to springs, coastlines, and wetlands during the Roman Iron Age and the Swedish Migration Period. Using QGIS, data from maps and literature is compiled to analyze fort locations and identify patterns using a Grounded Theory methodology.

    The research shows that wetlands influenced fort placement as a source of freshwater, cult sites and natural defenses. Springs, though less frequently located near forts, were more prominent in areas lacking other freshwater sources. The coast is ever prominent on the slim island, but settling near it likely had defensive advantages, as well as disadvantages. With the exception for one fort, people on Öland were unwilling to build forts on or near the shores.

    The study highlights the multifaceted relationship between the forts and water, lifting aspects such as defense, freshwater supply, and rituality. Furthermore, the essay suggests interesting locations for further research.

    Download full text (pdf)
    fulltext
  • Maier, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering, Civil Engineering and Built Environment.
    Modellering och analys av potential för värmeåtervinning i industriella destillationsprocesser: En fallstudie hos Cytiva Sweden AB med fokus på energi, utsläpp och ekonomisk lönsamhet.2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This case study evaluates the potential of recovery and utilization of waste heat from three solvent recovery distillation columns, conducted in collaboration with the biotech company Cytiva Sweden AB. Currently, waste heat from distillation processes is dissipated through conventional air-cooling systems without any heat recovery mechanism. Cytiva are assessing utilizing the waste heat with two distinct methods: using a vapor compression heat pump (HP) in a shared circulating cooling system serving multiple waste heat generating processes and implementing a semi-open mechanical vapor recompression system (MVR) within one of the three distillation processes, thereby substituting the conventional virgin steam-powered reboiler with a waste heat-fed alternative.

    The study pursues a dual objective. Firstly, it to develops a computational model based on simplified process schematics, fluid flows, and temperatures, encompassing five scenarios, including a baseline scenario devoid of waste heat recuperation or utilization. Two scenarios involving an HP within the cooling system, leveraging waste heat to elevate water temperatures from 50 ⁰C to the requisite 80 ⁰C for subsequent export into a district heating distribution grid. Another scenario integrates an MVR system into one distillation process, while conventionally cooling the remaining waste heat flows. Lastly, a combined scenario incorporates both the HP and MVR systems.

    Using operational parameters, energy prices, and emissions factors from 2023, the model identifies the optimal alternative based on energy savings, emission reduction, and economic profitability. The combined HP and MVR system emerges as the most favorable option, yielding annual energy savings of 14 500 MWh, a heat export of 9 800 MWh/year generating profits of 4.9 Mkr/year, emissions reductions of 2 000 tonCO2ekv/year, and a yearly total cost savings of 9.9 Mkr. However, the combined system is also the most expensive option. The independent nature of the two systems facilitates ease of installation and operation. These findings provide valuable insights for Cytiva in their efforts to mitigate environmental impact through heat recovery and utilization.

    Download full text (pdf)
    JohanMaier
  • Perón Flodström, Mirka
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Egyptology.
    Placement verbs in Earlier Egyptian: A functional semantic analysis of the verbs wAH, wd(i), and rdi2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study aims to semantically analyse the use of the three placement verbs wAH, wd(i), and rdi in Earlier Egyptian to investigate the nuances and development of the process of ‘placing’ in the language. A mixed methods approach was employed in the study using Systemic Functional Linguistics as the theoretical framework.

    The results show that the three verbs have distinct semantic profiles. The use of wd(i) and rdi changes after the Old Kingdom, whereas wAH remains more or less the same denoting a downward movement of the Goal. One of the verbs – wd(i) in the Old Kingdom and rdi after that – functions as a more general and frequent verb, although wd(i) already in the Old Kingdom shows a specific nuance of ‘firm placing’. Additionally, rdi is rare as a placement verb in the Old Kingdom, after which it is semantically bleached and becomes the general placement verb of the language. At the same time, the use of wd(i) diminishes. 

    Furthermore, the process of ‘placing’ in Earlier Egyptian tends to only include the participants Actor, Goal, and Location, whereas the other circumstances of the process are often more or less implicit. Consequently, the nuances of the process of ‘placing’ – especially with rdi after the Old Kingdom – can be interpreted from the combination of the participants and the co(n)text of the process as a whole. 

    Download full text (pdf)
    fulltext
  • Bell, Karen L.
    et al.
    CSIRO Hlth & Biosecur, Floreat, WA, Australia.;CSIRO Land & Water, Floreat, WA, Australia.;Univ Western Australia, Sch Biol Sci, Crawley, WA, Australia..
    Turo, Katherine J.
    Rutgers State Univ, Dept Ecol Evolut & Nat Resources, New Brunswick, NJ USA..
    Lowe, Abigail
    Natl Bot Garden Wales, Llanarthne, Wales..
    Nota, Kevin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Keller, Alexander
    Ludwig Maximilians Univ Munchen, Fac Biol, Bioctr, Organism & Cellular Networks, Planegg, Germany..
    Encinas-Viso, Francisco
    CSIRO, Ctr Australian Natl Biodivers Res, Black Mountain, ACT, Australia..
    Parducci, Laura
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Sapienza Univ Rome, Dept Environm Biol, Rome, Italy..
    Richardson, Rodney T.
    Univ Maryland, Appalachian Lab, Ctr Environm Sci, Frostburg, MD USA..
    Leggett, Richard M.
    Earlham Inst, Norwich Res Pk, Norfolk, VA USA..
    Brosi, Berry J.
    Univ Washington, Dept Biol, Seattle, WA 98195 USA..
    Burgess, Kevin S.
    Columbus State Univ, Univ Syst Georgia, Coll Letters & Sci, Dept Biol, Atlanta, GA USA..
    Suyama, Yoshihisa
    Tohoku Univ, Field Sci Ctr, Grad Sch Agr Sci, Osaki, Miyagi, Japan..
    de Vere, Natasha
    Univ Copenhagen, Nat Hist Museum Denmark, Copenhagen, Denmark..
    Plants, pollinators and their interactions under global ecological change: The role of pollen DNA metabarcoding2023In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 32, no 23, p. 6345-6362Article in journal (Refereed)
    Abstract [en]

    Anthropogenic activities are triggering global changes in the environment, causing entire communities of plants, pollinators and their interactions to restructure, and ultimately leading to species declines. To understand the mechanisms behind community shifts and declines, as well as monitoring and managing impacts, a global effort must be made to characterize plant-pollinator communities in detail, across different habitat types, latitudes, elevations, and levels and types of disturbances. Generating data of this scale will only be feasible with rapid, high-throughput methods. Pollen DNA metabarcoding provides advantages in throughput, efficiency and taxonomic resolution over traditional methods, such as microscopic pollen identification and visual observation of plant-pollinator interactions. This makes it ideal for understanding complex ecological networks and their responses to change. Pollen DNA metabarcoding is currently being applied to assess plant-pollinator interactions, survey ecosystem change and model the spatiotemporal distribution of allergenic pollen. Where samples are available from past collections, pollen DNA metabarcoding has been used to compare contemporary and past ecosystems. New avenues of research are possible with the expansion of pollen DNA metabarcoding to intraspecific identification, analysis of DNA in ancient pollen samples, and increased use of museum and herbarium specimens. Ongoing developments in sequencing technologies can accelerate progress towards these goals. Global ecological change is happening rapidly, and we anticipate that high-throughput methods such as pollen DNA metabarcoding are critical for understanding the evolutionary and ecological processes that support biodiversity, and predicting and responding to the impacts of change.

    Download full text (pdf)
    fulltext
  • Wineinger, Hannah
    et al.
    Univ Alabama, Dept Chem & Biochem, Tuscaloosa, AL 35487 USA.;Colorado Sch Mines, Dept Chem, 1500 Illinois St, Golden, CO 80401 USA.;Colorado Sch Mines, Nucl Sci & Engn Ctr, 1500 Illinois St, Golden, CO 80401 USA..
    Smetana, Volodymyr
    Stockholm Univ, Dept Mat & Environm Chem, Svante Arrhenius Vag 16 C, S-10691 Stockholm, Sweden.;Aarhus Univ, Dept Biol & Chem Engn, DK-8000 Aarhus C, Denmark.;Aarhus Univ, iNANO, DK-8000 Aarhus C, Denmark..
    Hiti, Ethan
    Univ Alabama, Dept Chem & Biochem, Tuscaloosa, AL 35487 USA..
    Baryshnikov, Glib
    Linköping Univ, Lab Organ Elect, Dept Sci & Technol, S-60174 Norrköping, Sweden..
    Qu, Fengrui
    Univ Alabama, Dept Chem & Biochem, Tuscaloosa, AL 35487 USA.;Univ Michigan, Dept Chem Engn, Chem 4307, 930 North Univ Ave, Ann Arbor, MI 48109 USA..
    Ågren, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Chemical and Bio-Molecular Physics.
    Mudring, Anja-Verena
    Stockholm Univ, Dept Mat & Environm Chem, Svante Arrhenius Vag 16 C, S-10691 Stockholm, Sweden.;Aarhus Univ, Dept Biol & Chem Engn, DK-8000 Aarhus C, Denmark.;Aarhus Univ, iNANO, DK-8000 Aarhus C, Denmark..
    Rogers, Robin D.
    Univ Alabama, Dept Chem & Biochem, Tuscaloosa, AL 35487 USA.;Stockholm Univ, Dept Mat & Environm Chem, Svante Arrhenius Vag 16 C, S-10691 Stockholm, Sweden.;Aarhus Univ, iNANO, DK-8000 Aarhus C, Denmark..
    Trapping an Unexpected/Unprecedented Hexanuclear Ce(III) Hydrolysis Product with Neutral 4-Amino-1,2,4-triazole2023In: European Journal of Inorganic Chemistry, ISSN 1434-1948, E-ISSN 1099-1948, Vol. 26, no 31, article id e202300450Article in journal (Refereed)
    Abstract [en]

    Using Ce(III) as both a representative lanthanide and actinide analog, the ability of mixtures of acidic and basic azoles to allow direct access to homoleptic N-donor f-element complexes in one pot reactions from hydrated salts as starting materials was examined by reacting mixtures of 4-amino-1,2,4-triazole (4-NH2-1,2,4-Triaz), 5-amino-tetrazole (5-NH2-HTetaz), and 1,2,3-triazole (1,2,3-HTriaz) in 1:1 and 1:3 ratios with CeCl3 center dot 7H(2)O, [C(2)mim](3)[CeCl6] ([C(2)mim](+) = 1-ethyl-2-methylimidazolium), and Ce(NO3)(3)center dot 6H(2)O. Although unsuccessful in our goal, structural analysis revealed that neutral 4-NH2-1,2,4-Triaz is structure directing via eta(2)mu(2)kappa(2) bridging, with the formation of the dinuclear complexes [Ce2Cl2(mu(2)-4-NH2-1,2,4-Triaz)(4)(H2O)(8)]Cl-4 center dot 4H(2)O, [Ce-2(mu(2)-4-NH2-1,2,4-Triaz)(4)(4-NH2-1,2,4-Triaz)(2)(Cl)(6)], and [4-NH2-1,2,4-HTriaz][Ce-2(mu(2)-4-NH2-1,2,4-Triaz)(2)(mu(2)-NO3)(NO3)(6)(H2O)(2)]. When the synthetic conditions favored hydrolysis, the hexanuclear Ce(III) complex [Ce-6(mu(3)-O)(4)(mu(3)-OH)(2)(mu(3)-Cl)(2)(Cl)(6)(mu(2)-4-NH2-1,2,4-Triaz)(12)]center dot 7H(2)O was isolated. This unexpected hydrolysis product represents the first example of a high nuclearity lanthanide complex where all Ln atoms are pairwise connected through 12 N-donor ligands or 12 neutral bridging ligands of any type, a rare example of incorporation of non-oxo coordinating anions in the M6X8 core, and the first reported Ce(III) hexanuclear complex of this type.

    Download full text (pdf)
    fulltext
  • Axelsson, Nils
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Integration of prescribed-performance and boundary-layer control for systems with uncertain dynamics2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Controlling systems with uncertain dynamics is crucial in systems theory, especially for unmanned vehicles operating in challenging and unknown environments. One key application involves developing control methods to ensure collision-free trajectory tracking for unmanned surface vehicles (USVs) at sea.

    Modern control methods for such systems often encounter unwanted high-frequency oscillations, known as chattering, in the control signals. To address this, continuous approximations of discontinuous functions in the control law have proven effective in reducing chattering. This approach is integrated into a prescribed-performance control scheme, which has previously achieved asymptotic tracking for systems with uncertain dynamics.

    We employ Lyapunov stability analysis to determine if theoretical bounds for error performance can be smaller than the prescribed funnel functions when incorporating continuous approximations in a boundary-layer. For both first- and second-order systems, we show that system trajectories reach an arbitrarily small boundary-layer set in finite time. This allows us to derive a priori known error bounds that are smaller than the prescribed funnels.

    Simulations support the theoretical results, demonstrating a significant reduction in chattering while achieving asymptotic tracking errors two orders of magnitude smaller than the funnel functions. 

    Download full text (pdf)
    fulltext
  • Somasiri, M D C Danushka
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Predictive Modelling for Efficient Electricity Management in E-car Charging: A Digital Twin Approach at Arlanda Airport2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Electricity vehicles usage these days is rapidly increasing due to energy demands problems. The future is aiming to reduce carbon emissions. SWEDAVIA is  the company in Sweden dealing with ten airports to handle air traffic throughout the airports. The future of SWEDAVIA airports would be moving to sustainable aviation fuels such as electricity, hydrogen gas, solar power, and other sustainable solutions. This thesis uses digital twin technologies and predictive modelling to optimize energy use for EV charging at Arlanda Airport. In order to minimize energy usage while also flattering out usage spikes, the study makes use of historical data to produce an elaborate predictive model of the airport's infrastructure for charging. The research project proposes and evaluates a prediction model that captures the temporal patterns of energy use for EV charging using the Design Science Research (DSR) approach. The research identifies crucial peak times as well as variables like day of the week, time of day, and weather conditions that affect energy use. The report suggests workable solutions to better control energy consumption, such as moving energy demand to off-peak hours and improving charging station effectiveness. The Mean Squared Error (MSE) of the predictive model's accuracy illustrates how crucial it is to include comprehensive data sets for accurate predictions. The study highlights how the use of Digital Twin technology in airports may improve operational effectiveness and facilitate sustainable energy management.

    Download full text (pdf)
    fulltext
  • Holmberg, Amanda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Arleij, Emily
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Digitalt och socialt inkluderade: En kvalitativ intervjustudie om äldre personers erfarenheter och anpassningar i en växande digital värld2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Digitaliseringen av samhället och dess medförda förändringar innebär både möjligheter och utmaningar för äldre personer, särskilt gällande deras förmåga att navigera i sin användning av digitala verktyg och tjänster. Syftet med denna studie är att utforska hur äldre personers digitala delaktighet hör ihop med deras upplevelse av social inkludering. Studiens frågeställningar är “Hur navigerar informanterna i sin användning av digitala verktyg för att skapa mening och konstruera sin sociala verklighet?” samt “Hur upplever informanterna att behärskandet av och skickligheten i användningen av digitala verktyg hör ihop med deras sociala relationer och nätverk?”. Det teoretiska ramverket kombinerar George Herbert Meads begrepp Den generaliserade andre och Herbert Blumers Symboliska interaktionism. Teorierna tillämpas för att analysera informanternas förståelse för och användning av digitala verktyg samt hur det relaterar till deras sociala relationer och nätverk. Studien utgår från ett kvalitativt tillvägagångssätt och har inslag från fenomenologin. Studiens material är insamlat genom semistrukturerade intervjuer med elva personer över 75 år. Resultaten från studien tyder på att informanterna aktivt använder digitala verktyg för att upprätthålla sociala kontakter och känna sig delaktiga i samhället. Det framkommer samtidigt en rädsla bland informanterna för att bli exkluderade från samhället om de avstår från att hänga med i den digitala utvecklingen. Specifika farhågor kretsar kring att göra fel i teknikanvändningen och för bedrägerier online. Resultaten belyser även vikten av gatekeepers, personer som utgör stödpunkter i våra intervjupersoners digitala användning. De här personerna betonas som avgörande för att informanterna ska känna trygghet och kompetens samt för att de ska förmå att kunna överkomma hinder i teknikanvändningen. Sammanfattningsvis understryker studiens resultat den komplexitet som förekommer i intervjupersonernas interaktioner med digitala verktyg. Studien bidrar till insikter om äldre individers erfarenheter och anpassningar till en värld som är organiserad kring digitala produkter och aktiviteter, samt hur de kan influera deras sociala och digitala inkludering.

    Download full text (pdf)
    fulltext
  • Welander, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Fair and Efficient Federated Learning for Network Optimization with Heteroscedastic Data2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The distributed and privacy sensitive nature of cellular networks make them strong candidates for optimization using Federated Learning, but this exposes them to a problem inherent to the learning paradigm: performance inequality due to heterogeneous client data distributions. The prevailing approach of enforcing uniform client performance ignores client-specific performance limitations due to different levels of irreducible uncertainty present in their data, resulting in deteriorated network performance. To address this issue, this thesis introduces two novel federated algorithms designed to enhance learning efficiency and ensure fairness in the presence of heteroscedastic noise, reflecting the distributive justice principles of utilitarianism and equality. Under these circumstances, the proposed algorithms are shown to significantly improve overall performance and performance fairness. The deployment of these algorithms promises a dual benefit: enhancement in network performance and a fairer distribution of service quality for end users.

    Download full text (pdf)
    fulltext
  • Daisse, Gilda
    et al.
    Univ Nat Resources & Life Sci Vienna, Christian Doppler Lab, Peter Jordanstr 82, A-1190 Vienna, Austria..
    Abali, Bilen Emek
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Mechanics.
    Wan-Wendner, Roman
    Univ Nat Resources & Life Sci Vienna, Christian Doppler Lab, Peter Jordanstr 82, A-1190 Vienna, Austria.;Univ Ghent, Dept Struct Engn & Bldg Mat, Tech Lane Ghent Sci Pk Campus A,Technol Pk Zwijnaa, B-9052 Ghent, Belgium.;Univ Nat Resources & Life Sci, Dept Mat Sci & Proc Engn, Peter Jordanstr 82, A-1190 Vienna, Austria..
    Tensile and Shear Creep Behavior of Structural Adhesives: Experiments and Modeling2024In: Applied Composite Materials, ISSN 0929-189X, E-ISSN 1573-4897, Vol. 31, no 2, p. 739-764Article in journal (Refereed)
    Abstract [en]

    Structural adhesives characterized a turning point in the post-connection of structural elements due to their excellent performances and ability to transfer stress without losing their integrity. These materials are typically particle-reinforced composites made by a thermoset polymer matrix and fillers. During the in-situ application of this material, the thermal activation of the polymer is typically not possible, leading to an undefined degree of cure and therefore to a variation of the mechanical performance over time. This altering means that after applying a sustained load on a bonded anchor system installed at regular temperature, the adhesive changes material properties. Ample studies convince that the progressive increase of the degree of cure of the thermosetting polymer leads to higher strength and stiffness. However, limited studies have been dedicated to the post-curing effects on the long-term behavior. The main goal of this work is to investigate the tensile and shear creep behavior of two commercially available structural adhesives and the influence of curing conditions on their long-term performances. An extensive experimental campaign comprising short and long-term characterizations has been carried out on specimens subjected to three different curing and post-curing protocols, with the scope of imitating relevant in-situ conditions. The results demonstrate that structural adhesives cured at higher temperatures are less subjected to creep deformations. As a material equation, the generalized Kelvin model is utilized to fit the tensile and shear creep data, and two continuous creep spectra have been selected to represent the creep behavior and facilitate extrapolations to the long-term behavior.

    Download full text (pdf)
    FULLTEXT01
  • Eriksson, Amanda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Rydberg, Linnéa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Duktiga flickor och prestationsförväntningar: En kvalitativ intervjustudie om unga kvinnors upplevelser kring prestation och förväntningar på arbetsplatser2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsen fokuserar på att undersöka “duktiga flickan-syndromet” i yrkeslivet. Tidigare forskning har visat att könsspecifika förväntningar sätts tidigt i åldern, något som senare följer med kvinnor i livet. Dessa könsspecifika förväntningar kan innebära att det sätts mer emotionella krav på flickor. Tidigare forskning visar att kvinnor kan uppleva andra utmaningar än män i arbetslivet. Uppsatsen fokuserar på att, genom att intervjua unga kvinnor med erfarenhet av arbetslivet, undersöka unga kvinnors interaktioner och emotioner på och kring arbetet. Syftet med vår uppsats är att undersöka närmare de samhälleliga normer och förväntningar kring prestation som unga kvinnor upplever relaterat till “duktiga flickan-syndromet”. Genom att studera unga kvinnors erfarenheter av prestation, deras självuppfattning och handlingsmönster i yrkesmässiga sammanhang strävar studien efter att identifiera och analysera de förväntningar som präglar deras beteende och självbild. Undersökningen strävar därav att bidra till en djupare förståelse för hur “duktiga flickan-syndromet” kan influera unga kvinnors emotionella upplevelser. Det empiriska materialet har samlats in genom 10 semistrukturerade intervjuer. Vidare har en fenomenologisk ansats tillämpats och det empiriska materialet har kodats och analyserats genom ett induktivt tillvägagångssätt. Det teoretiska ramverket som tillämpas i denna studie är symbolisk interaktionism, Goffmans dramaturgiska perspektiv och Hochschilds teoretiska bidrag kring känslohantering. Resultatet visar att det finns en förväntning på kvinnor att vara duktiga och att detta är något som har uppkommit redan från tidig ålder i sociala sammanhang. Därefter visar resultatet att kvinnor intar en roll på arbetsplatser i syfte att  förmedla en bild av sig själv som motsvarar den sociala omgivningens förväntningar, men även för att motverka fördomar som finns kring unga kvinnor på arbetsplatser. Resultatet visar även att det finns emotionella dimensioner av arbetslivet. Det empiriska materialet tyder  på att det är förekommande att inte känna sig tillräcklig på arbetsplatsen och att det kan återkopplas till förväntningar och strävan efter beröm.

    Download full text (pdf)
    fulltext
  • Wiesner, Rebecca
    et al.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany..
    Zagst, Holger
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany..
    Lan, Wenkui
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany.;Bristol Myers Squibb, New Brunswick, NJ USA..
    Bigelow, Stewart
    Hlth Canada, Ottawa, ON, Canada..
    Holper, Peter
    AB SCIEX LLC, Redwood City, CA USA..
    Huebner, Goeran
    Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany..
    Josefsson, Leila
    Kantisto BV, Baarn, Netherlands..
    Lancaster, Claire
    Regeneron Pharmaceut Inc, Tarrytown, NY USA..
    Lo, Lili
    Bristol Myers Squibb, New Brunswick, NJ USA..
    Loessner, Christopher
    Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany..
    Lu, Huixin
    Neusuess, Christian
    Hsch Aalen, Fac Chem, Aalen, Germany..
    Ruettiger, Carolin
    Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany.;Hsch Aalen, Fac Chem, Aalen, Germany..
    Schlecht, Johannes
    Schuerrle, Philipp
    Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany..
    Selsam, Alexander
    Boehringer Ingelheim Pharm GmbH & Co KG, Biberach An Der Riss, Germany..
    van der Burg, Debbie
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany.;Kantisto BV, Baarn, Netherlands.;KTH Royal Inst Technol, Sch Engn Sci Chem, Dept Chem, Stockholm, Sweden..
    Wang, Shao-Chun
    Regeneron Pharmaceut Inc, Tarrytown, NY USA..
    Zhu, Yunxiao
    Bristol Myers Squibb, New Brunswick, NJ USA..
    Waetzig, Hermann
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany.;Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany..
    Sänger-van de Griend, Cari
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry. Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Braunschweig, Germany.;Kantisto BV, Baarn, Netherlands.;Kantisto BV, Callenburglaan 22, NL-3742 MV Baarn, Netherlands..
    An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and ε-aminocaproic acid lots2023In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 44, no 15-16, p. 1247-1257Article in journal (Refereed)
    Abstract [en]

    Capillary zone electrophoresis ultraviolet (CZE-UV) has become increasingly popular for the charge heterogeneity determination of mAbs and vaccines. The epsilon-aminocaproic acid (eACA) CZE-UV method has been used as a rapid platform method. However, in the last years, several issues have been observed, for example, loss in electrophoretic resolution or baseline drifts. Evaluating the role of eACA on the reported issues, various laboratories were requested to provide their routinely used eACA CZE-UV methods, and background electrolyte compositions. Although every laboratory claimed to use the He et al. eACA CZE-UV method, most methods actually deviate from He's. Subsequently, a detailed interlaboratory study was designed wherein two commercially available mAbs (Waters' Mass Check Standard mAb [pI 7] and NISTmAb [pI 9]) were provided to each laboratory, along with two detailed eACA CZE-UV protocols for a short-end, high-speed, and a long-end, high-resolution method. Ten laboratories participated each using their own instruments, and commodities, showing excellence method performance (relative standard deviations [RSDs] of percent time-corrected main peak areas from 0.2% to 1.9%, and RSDs of migration times from 0.7% to 1.8% [n = 50 per laboratory], analysis times in some cases as short as 2.5 min). This study clarified that eACA is not the main reason for the abovementioned variations.

    Download full text (pdf)
    fulltext