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  • Andersson, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    A Swedish Nuclear Future: Using explorative scenarios to assess energy security in low-carbon electricity systems2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Positioned within the concepts of sustainable development and energy security, this study evaluates the prospects for Swedish electricity production to assist in reaching both national and international climate targets. The main purpose is to assess the capability of nuclear energy to form part of a national climate change mitigation approach, as well as a viable energy source for Sweden to rely on in the future. Swedish energy security is quantitatively analyzed from a scheme based on the 4 As of energy security and with the use of a two-dimensional decision matrix. Swedish electricity production has a long record of being characterized by high levels of reliability and performance. It is also almost entirely fossil free, a situation largely explained by the significant shares of electricity being generated from nuclear and hydropower. However, current national market conditions are causing a strained financial situation for the existing nuclear power plants. Therefore, this study also performs an explorative scenario analysis on what could happen to the Swedish energy system if certain factors were to experience substantial changes in the years to come. The results from the energy security analysis demonstrate that, in order to facilitate reaching established climate targets, all of the current main sources of power generation are viable to include in a national electricity mix. Furthermore, in maintaining the current electricity production, the scenario analysis highlights three factors which seem to be of particular importance. These are: production costs for different energy sources; public opinion regarding significant societal developments; and rising emissions taxes. The findings also indicate that nuclear energy constitutes a suitable and reliable source of base load electricity and that maintaining a diversified energy mix, in terms of energy security, is a sound pathway for Sweden to follow.

  • Appelgren, Daniel
    et al.
    Linkoping Univ, Div Drug Res, Dept Med & Hlth Sci, SE-58185 Linkoping, Sweden.
    Enocsson, Helena
    Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden.
    Skogman, Barbro H.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Orebro Univ, Fac Med & Hlth Sci, SE-70281 Orebro, Sweden.
    Nordberg, Marika
    Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland.
    Perander, Linda
    Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland.
    Nyman, Dag
    Bimelix AB, AX-22100 Mariehamn, Aland, Finland.
    Nyberg, Clara
    Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland.
    Knopf, Jasmin
    Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Univ Klinikum Erlangen, DE-91054 Erlangen, Germany.
    Munoz, Luis E.
    Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Univ Klinikum Erlangen, DE-91054 Erlangen, Germany.
    Sjöwall, Christopher
    Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden.
    Sjöwall, Johanna
    Linkoping Univ Hosp, Clin Infect Dis, SE-58185 Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden.
    Neutrophil Extracellular Traps (NETs) in the Cerebrospinal Fluid Samples from Children and Adults with Central Nervous System Infections2020In: CELLS, ISSN 2073-4409, Vol. 9, no 1, article id 43Article in journal (Refereed)
    Abstract [en]

    Neutrophils operate as part of the innate defence in the skin and may eliminate the Borrelia spirochaete via phagocytosis, oxidative bursts, and hydrolytic enzymes. However, their importance in Lyme neuroborreliosis (LNB) is unclear. Neutrophil extracellular trap (NET) formation, which is associated with the production of reactive oxygen species, involves the extrusion of the neutrophil DNA to form traps that incapacitate bacteria and immobilise viruses. Meanwhile, NET formation has recently been studied in pneumococcal meningitis, the role of NETs in other central nervous system (CNS) infections has previously not been studied. Here, cerebrospinal fluid (CSF) samples from clinically well-characterised children (N = 111) and adults (N = 64) with LNB and other CNS infections were analysed for NETs (DNA/myeloperoxidase complexes) and elastase activity. NETs were detected more frequently in the children than the adults (p = 0.01). NET presence was associated with higher CSF levels of CXCL1 (p < 0.001), CXCL6 (p = 0.007), CXCL8 (p = 0.003), CXCL10 (p < 0.001), MMP-9 (p = 0.002), TNF (p = 0.02), IL-6 (p < 0.001), and IL-17A (p = 0.03). NETs were associated with fever (p = 0.002) and correlated with polynuclear pleocytosis (r(s) = 0.53, p < 0.0001). We show that neutrophil activation and active NET formation occur in the CSF samples of children and adults with CNS infections, mainly caused by Borrelia and neurotropic viruses. The role of NETs in the early phase of viral/bacterial CNS infections warrants further investigation.

  • Spronk, Inge
    et al.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, POB 2040, NL-3000 CA Rotterdam, Netherlands;Maasstad Hosp, Assoc Dutch Burn Ctr, Rotterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci, Amsterdam, Netherlands.
    Edgar, Dale W.
    Fiona Stanley Hosp, State Adult Burn Unit, Murdoch, WA, Australia;Univ Notre Dame, Burn Injury Res Node, Fremantle, WA, Australia;Fiona Wood Fdn, Murdoch, WA, Australia.
    van Baar, Margriet E.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, POB 2040, NL-3000 CA Rotterdam, Netherlands;Maasstad Hosp, Assoc Dutch Burn Ctr, Rotterdam, Netherlands.
    Wood, Fiona M.
    Fiona Stanley Hosp, State Adult Burn Unit, Murdoch, WA, Australia;Fiona Wood Fdn, Murdoch, WA, Australia.
    Van Loey, Nancy E. E.
    Assoc Dutch Burn Ctr, Dept Behav Res, Beverwijk, Netherlands;Univ Utrecht, Dept Clin Psychol, Utrecht, Netherlands.
    Middelkoop, Esther
    Vrije Univ Amsterdam, Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci, Amsterdam, Netherlands;Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
    Renneberg, Babette
    Free Univ Berlin, Dept Clin Psychol & Psychotherapy, Berlin, Germany.
    Öster, Caisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ekselius: Psychiatry.
    Orwelius, Lotti
    Linkoping Univ, Dept Anaesthesiol & Intens Care, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Moi, Asgjerd L.
    Western Norway Univ Appl Sci, Fac Hlth & Social Sci, Dept Hlth & Caring Sci, Bergen, Norway;Haukeland Hosp, Natl Burn Ctr, Dept Plast Hand & Reconstruct Surg, Bergen, Norway.
    Nieuwenhuis, Marianne
    Martini Hosp, Assoc Dutch Burn Ctr, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Ctr Human Movement Sci, Groningen, Netherlands.
    van der Vlies, Cornelis H.
    Maasstad Hosp, Burn Ctr, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Surg, Trauma Res Unit, Rotterdam, Netherlands.
    Polinder, Suzanne
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, POB 2040, NL-3000 CA Rotterdam, Netherlands.
    Haagsma, Juanita A.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, POB 2040, NL-3000 CA Rotterdam, Netherlands.
    Improved and standardized method for assessing years lived with disability after burns and its application to estimate the non-fatal burden of disease of burn injuries in Australia, New Zealand and the Netherlands2020In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 20, article id 121Article in journal (Refereed)
    Abstract [en]

    Background: Burden of disease estimates are an important resource in public health. Currently, robust estimates are not available for the burn population. Our objectives are to adapt a refined methodology (INTEGRIS method) to burns and to apply this new INTEGRIS-burns method to estimate, and compare, the burden of disease of burn injuries in Australia, New Zealand and the Netherlands.

    Methods: Existing European and Western-Australian health-related quality of life (HRQL) datasets were combined to derive disability weights for three homogenous burn injury groups based on percentage total body surface area (%TBSA) burned. Subsequently, incidence data from Australia, New Zealand, and the Netherlands from 2010 to 2017 were used to compute annual non-fatal burden of disease estimates for each of these three countries. Non-fatal burden of disease was measured by years lived with disability (YLD).

    Results: The combined dataset included 7159 HRQL (EQ-5D-3 L) outcomes from 3401 patients. Disability weights ranged from 0.046 (subgroup < 5% TBSA burned > 24 months post-burn) to 0.497 (subgroup > 20% TBSA burned 0-1 months post-burn). In 2017 the non-fatal burden of disease of burns for the three countries (YLDs/100,000 inhabitants) was 281 for Australia, 279 for New Zealand and 133 for the Netherlands.

    Conclusions: This project established a method for more precise estimates of the YLDs of burns, as it is the only method adapted to the nature of burn injuries and their recovery. Compared to previous used methods, the INTEGRIS-burns method includes improved disability weights based on severity categorization of burn patients; a better substantiated proportion of patients with lifelong disability based; and, the application of burn specific recovery timeframes. Information derived from the adapted method can be used as input for health decision making at both the national and international level. Future studies should investigate whether the application is valid in low- and middle- income countries.

  • Moore, Amy
    et al.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Kane, Eleanor
    Univ York, Dept Hlth Sciences, York, N Yorkshire, England.
    Wang, Zhaoming
    St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA;NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Panagiotou, Orestis A.
    Brown Univ, Sch Publ Hlth, Dept Hlth Serv Policy & Practice, Providence, RI 02912 USA;Brown Univ, Sch Publ Hlth, Ctr Gerontol & Healthcare Res, Providence, RI 02912 USA.
    Teras, Lauren R.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Monnereau, Alain
    INSERM, Epidemiol Childhood & Adolescent Canc Grp, Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Paris, France;Univ Paris 05, Paris, France;Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France.
    Wong Doo, Nicole
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Machiela, Mitchell J.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Skibola, Christine F.
    Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA.
    Slager, Susan L.
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
    Salles, Gilles
    Hosp Civils Lyon, Dept Hematol, Lyon, France;Univ Lyon 1, Dept Hematol, Lyon, France;Inst Natl Sante & Rech Med UMR1052 Pierre Benite, Canc Res Ctr Lyon, Equipe Expt & Clin Models Lymphomagenesis, Lyon, France.
    Camp, Nicola J.
    Univ Utah, Sch Med, Dept Internal Med, Div Hematol & Hematol Malignancies, Salt Lake City, UT USA;Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT USA.
    Bracci, Paige M.
    Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
    Nieters, Alexandra
    Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany.
    Vermeulen, Roel C. H.
    Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
    Vijai, Joseph
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Smedby, Karin E.
    Karolinska Inst, Dept Med, Solna, Solna, Sweden;Karolinska Univ Hosp, Hematol Ctr, Stockholm, Sweden.
    Zhang, Yawei
    Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA.
    Vajdic, Claire M.
    Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia.
    Cozen, Wendy
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA;Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA.
    Spinelli, John J.
    BC Canc, Canc Control Res, Vancouver, BC, Canada;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
    Hjalgrim, Henrik
    Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, Copenhagen, Denmark.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
    Link, Brian K.
    Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA.
    Clavel, Jacqueline
    INSERM, Epidemiol Childhood & Adolescent Canc Grp, Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Paris, France;Univ Paris 05, Paris, France.
    Arslan, Alan A.
    NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA;NYU, Sch Med, Dept Environm Med, New York, NY USA;NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY USA.
    Purdue, Mark P.
    Ontario Hlth Study, Toronto, ON, Canada.
    Tinker, Lesley F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Ferri, Giovanni M.
    Univ Bari, Interdisciplinary Dept Med, Bari, Italy.
    Habermann, Thomas M.
    Mayo Clin, Coll Med & Sci, Div Gen Internal Med, Rochester, MN USA.
    Adami, Hans-Olov
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Harvard Sch Publ Hlth, Dept Epidmiol, Boston, MA USA.
    Becker, Nikolaus
    German Canc Res Ctr, Div Canc Epidmiol, Heidelberg, Germany.
    Benavente, Yolanda
    Catalan Inst OncologyIDIBELL, Canc Epidemiol Res Programme, Barcelona, Spain;CIBER Epidemiol & Salud Publ, Barcelona, Spain.
    Bisanzi, Simonetta
    Prevent & Res Inst ISPRO, Oncol Network, Reg Canc Prevent Lab, Florence, Italy.
    Boffetta, Paolo
    Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
    Brennan, Paul
    IARC, Lyon, France.
    Brooks-Wilson, Angela R.
    BC Canc, Genome Sci Ctr, Vancouver, BC, Canada;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada.
    Canzian, Federico
    German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.
    Conde, Lucia
    UCL, Inst Canc, Bill Lyons Informat Ctr, London, England.
    Cox, David G.
    Ctr Leon Berard, Canc Res Ctr Lyon, INSERM, U1052, Lyon, France.
    Curtin, Karen
    Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT USA.
    Foretova, Lenka
    Masaryk Mem Canc Inst & MF MU, Dept Canc Epidemiol & Genet, Brno, Czech Republic.
    Gapstur, Susan M.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Ghesquieres, Herve
    Inst Natl Sante & Rech Med UMR1052 Pierre Benite, Canc Res Ctr Lyon, Equipe Expt & Clin Models Lymphomagenesis, Lyon, France;Ctr Leon Berard, Dept Hematol, Lyon, France.
    Glenn, Martha
    Huntsman Canc Inst, Dept Internal Med, Salt Lake City, UT USA.
    Glimelius, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Jackson, Rebecca D.
    Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH USA.
    Lan, Qing
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Liebow, Mark
    Mayo Clin, Coll Med & Sci, Div Gen Internal Med, Rochester, MN USA.
    Maynadie, Marc
    Univ Burgundy, Registre Hemopathies Malignes Cote dOr, INSERM, U1231, Dijon, France;Dijon Univ Hosp, Dijon, France.
    McKay, James
    IARC, Lyon, France.
    Melbye, Mads
    Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, Copenhagen, Denmark;Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
    Miligi, Lucia
    Prevent & Res Inst ISPRO, Oncol Network, Environm & Occupat Epidemiol Unit, Florence, Italy.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
    Molina, Thierry J.
    Univ Paris 05, Sorbonne Paris Cite, Necker Enfants Malades, Dept Pathol,AP HP, Paris, France.
    Morton, Lindsay M.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    North, Kari E.
    Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA;Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27515 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Padoan, Marina
    Univ Piemonte Orientale, Dept Translat Med, CPO Piemonte, Novara, Italy;Univ Piemonte Orientale, Dept Translat Med, Unit Med Stat & Epidemiol, Novara, Italy.
    Patel, Alpa V.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Piro, Sara
    Prevent & Res Inst ISPRO, Oncol Network, Environm & Occupat Epidemiol Unit, Florence, Italy.
    Ravichandran, Vignesh
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, London, England.
    de Sanjose, Silvia
    Catalan Inst OncologyIDIBELL, Canc Epidemiol Res Programme, Barcelona, Spain;CIBER Epidemiol & Salud Publ, Barcelona, Spain.
    Severson, Richard K.
    Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
    Southey, Melissa C.
    Univ Melbourne, Dept Pathol, Genet Epidmiol Lab, Melbourne, Vic, Australia.
    Staines, Anthony
    Dublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland.
    Stewart, Carolyn
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Travis, Ruth C.
    Univ Oxford, Canc Epidmiol Unit, Oxford, England.
    Weiderpass, Elisabete
    World Hlth Org, Int Agcy Res Canc, Lyon, France.
    Weinstein, Stephanie
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Zheng, Tongzhang
    Brown Sch Publ Hlth, Dept Epidmiol, Providence, RI USA.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Chatterjee, Nilanjan
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA;Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA.
    Rothman, Nathaniel
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Birmann, Brenda M.
    Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Cerhan, James R.
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Genetically Determined Height and Risk of Non-hodgkin Lymphoma2020In: Frontiers in Oncology, ISSN 2234-943X, E-ISSN 2234-943X, Vol. 9, article id 1539Article in journal (Refereed)
    Abstract [en]

    Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

  • Källström, Jacob
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Troedsson, Joel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Programmering på lågstadiet – En kvalitativ studie om lärares upplevelser2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Programmering har införts i läroplanen och från och med sommaren 2018 ska lågstadielärare undervisa i programmering. När den här studien tar vid, våren 2019 har lågstadielärare undervisat i programmering i snart ett läsår. Syftet är att undersöka hur sju lågstadielärare upplever sina kunskaper och vilka utmaningar de ser när det kommer till att undervisa om programmering. Tidigare forskning är gjord innan ändringarna i läroplanen har tillämpats och den har visat på lärares förutsättningar, attityder, upplevda hinder och utmaningar kring att undervisa om programmering. Nu har lågstadielärare undervisat i programmering i snart ett läsår och den här studien bidrar med kunskap genom att undersöka hur situationen ser ut idag. Upplever lärare att de har den kunskap som behövs för att undervisa om programmering och vilka är utmaningarna? Studien genomfördes i maj 2019 i form av intervjuer där lågstadielärare valdes ut genom ett bekvämlighetsurval via kontakter från tidigare praktik. Studiens två frågeställningar är:

    1. Hur upplever lågstadielärare sina kunskaper inom programmering?
    2. Vilka utmaningar upplever lågstadielärare i att undervisa om programmering?

    För att synliggöra lågstadielärarnas upplevelser har en fenomenografisk utgångspunkt tillämpats vilket innebär att det är deltagarnas upplevelser kring ett fenomen som undersöks. Ett fenomen är en företeelse i omvärlden och den här studien undersöker lågstadielärares upplevelser om sin kunskap och utmaningar i att undervisa om programmering. Med en fenomenografisk utgångspunkt kategoriserades lågstadielärarnas upplevelser in i sex olika teman som utgår från studiens två frågeställningar. Dessa teman analyserades utifrån ett ramfaktorteoretiskt perspektiv för att synliggöra vilka ramfaktorer som påverkar dessa teman. Tre viktiga ramfaktorer kunde identifieras: ”Bristande fortbildning”, ”Tidsbrist” och ”Resurser”. Studiens resultat visar på lågstadielärarnas upplevelser om sin kunskap och utmaningar att undervisa i programmering och vilka ramfaktorer som påverkar dessa upplevelser.

  • Andersson, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    En komparativ studie om upplevd autonomi hos rektorer i Norge och Sverige2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study is a comparative survey on the experiences of autonomy of Norwegian and Swedish principals. The study uses theories and earlier research regarding teachers and autonomy. The research design that is used has in earlier research been used to study the autonomy of teachers. The experiences of autonomy is studied through questions on decision-making and control within four domains in which the principal operates: the pedagogical domain, the social domain, the domain of development and the administrative domain.

     

    The study shows that the principals in Norway and Sweden are governed in much the same manner regarding laws and curriculum in their respective countries. The level in which the principals experience themselves as autonomous in their work is approximately the same in Sweden and Norway. Although, the study suggests that there is a small discrepancy among the Norwegian principals who experience a slightly higher level of autonomy.

     

  • Sankaranarayanan, Sundar Ram
    et al.
    Jawaharlal Nehru Ctr Adv Sci Res, Mol Mycol Lab, Mol Biol & Genet Unit, Bengaluru, India.
    Ianiri, Giuseppe
    Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA;Univ Molise, Dept Agr Environm & Food Sci, Campobasso, Italy.
    Coelho, Marco A.
    Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA.
    Reza, Md Hashim
    Jawaharlal Nehru Ctr Adv Sci Res, Mol Mycol Lab, Mol Biol & Genet Unit, Bengaluru, India.
    Thimmappa, Bhagya C.
    Jawaharlal Nehru Ctr Adv Sci Res, Mol Mycol Lab, Mol Biol & Genet Unit, Bengaluru, India;Univ Montreal, Robert Cedergren Ctr Bioinformat & Genom, Dept Biochem, Montreal, PQ, Canada.
    Ganguly, Promit
    Jawaharlal Nehru Ctr Adv Sci Res, Mol Mycol Lab, Mol Biol & Genet Unit, Bengaluru, India.
    Vadnala, Rakesh Netha
    Inst Math Sci HBNI, Chennai, Tamil Nadu, India.
    Sun, Sheng
    Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA.
    Siddharthan, Rahul
    Inst Math Sci HBNI, Chennai, Tamil Nadu, India.
    Tellgren-Roth, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dawson, Thomas L. Jnr
    ASTAR, Skin Res Inst Singapore, Singapore, Singapore;Med Univ South Carolina, Dept Drug Discovery, Charleston, SC 29425 USA.
    Heitman, Joseph
    Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA.
    Sanyal, Kaustuv
    Jawaharlal Nehru Ctr Adv Sci Res, Mol Mycol Lab, Mol Biol & Genet Unit, Bengaluru, India.
    Loss of centromere function drives karyotype evolution in closely related Malassezia species2020In: eLIFE, E-ISSN 2050-084X, Vol. 9, article id e53944Article in journal (Refereed)
    Abstract [en]

    Genomic rearrangements associated with speciation often result in variation in chromosome number among closely related species. Malassezia species show variable karyotypes ranging between six and nine chromosomes. Here, we experimentally identified all eight centromeres in M. sympodialis as 3-5-kb long kinetochore-bound regions that span an AT-rich core and are depleted of the canonical histone H3. Centromeres of similar sequence features were identified as CENP-A-rich regions in Malassezia furfur, which has seven chromosomes, and histone H3 depleted regions in Malassezia slooffiae and Malassezia globosa with nine chromosomes each. Analysis of synteny conservation across centromeres with newly generated chromosome-level genome assemblies suggests two distinct mechanisms of chromosome number reduction from an inferred nine-chromosome ancestral state: (a) chromosome breakage followed by loss of centromere DNA and (b) centromere inactivation accompanied by changes in DNA sequence following chromosome-chromosome fusion. We propose that AT-rich centromeres drive karyotype diversity in the Malassezia species complex through breakage and inactivation.

  • Shah, Sonia
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    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England.
    Henry, Albert
    UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England.
    Roselli, Carolina
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
    Lin, Honghuang
    Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02118 USA;NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA.
    Sveinbjornsson, Gardar
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Fatemifar, Ghazaleh
    UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England.
    Hedman, Asa K.
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.
    Wilk, Jemma B.
    Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Morley, Michael P.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
    Chaffin, Mark D.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.
    Helgadottir, Anna
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Verweij, Niek
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
    Dehghan, Abbas
    Imperial Coll London, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England;Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, St Marys Campus, London W2 1PG, England.
    Almgren, Peter
    Lund Univ, Dept Clin Sci, Malmo, Sweden.
    Andersson, Charlotte
    NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA;Herlev Gentofte Hosp, Dept Cardiol, Herlev Ringvej 57, DK-2650 Herlev, Denmark.
    Aragam, Krishna G.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
    Arnlov, Johan
    Karolinska Inst, Sect Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden;Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.
    Backman, Joshua D.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Biggs, Mary L.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA;Univ Washington, Dept Med, Seattle, WA USA.
    Bloom, Heather L.
    Emory Univ, Dept Med, Med Ctr, Div Cardiol, Atlanta, GA 30322 USA.
    Brandimarto, Jeffrey
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
    Brown, Michael R.
    Univ Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
    Buckbinder, Leonard
    Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Carey, David J.
    Geisinger, Dept Mol & Funct Genom, Danville, PA USA.
    Chasman, Daniel I.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Chen, Xing
    Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Chen, Xu
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Chung, Jonathan
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Chutkow, William
    Novartis Inst Biomed Res, Cambridge, MA USA.
    Cook, James P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.
    Delgado, Graciela E.
    Heidelberg Univ, Med Fac Mannheim, Dept Med Nephrol Hypertensiol Endocrinol Diabetol, Heidelberg, Germany.
    Denaxas, Spiros
    UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;UCL, Natl Inst Hlth Res, Hosp Biomed Res Ctr, London, England;Alan Turing Inst, London, England.
    Doney, Alexander S.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Doerr, Marcus
    Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
    Dudley, Samuel C.
    Univ Minnesota, Dept Med, Cardiovasc Div, Minneapolis, MN USA.
    Dunn, Michael E.
    Regeneron Pharmaceut, Cardiovasc Res, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Engstrom, Gunnar
    Lund Univ, Dept Clin Sci, Malmo, Sweden.
    Esko, Tonu
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
    Felix, Stephan B.
    Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
    Finan, Chris
    UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England.
    Ford, Ian
    Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland.
    Ghanbari, Mohsen
    Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
    Ghasemi, Sahar
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Giulianini, Franco
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.
    Gottdiener, John S.
    Univ Maryland, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21201 USA.
    Gross, Stefan
    Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
    Gudbjartsson, Daniel F.
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland.
    Gutmann, Rebecca
    Univ Iowa, Carver Coll Med, Div Cardiovasc Med, Iowa City, IA USA.
    Haggerty, Christopher M.
    Geisinger, Dept Mol & Funct Genom, Danville, PA USA.
    van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.
    Hyde, Craig L.
    Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Ingelsson, Erik
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
    Jukema, J. Wouter
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands;LUMC, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.
    Kavousi, Maryam
    Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 0QQ, England.
    Kleber, Marcus E.
    Heidelberg Univ, Med Fac Mannheim, Dept Med Nephrol Hypertensiol Endocrinol Diabetol, Heidelberg, Germany.
    Kober, Lars
    Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.
    Koekemoer, Andrea
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
    Langenberg, Claudia
    Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Lindgren, Cecilia M.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
    London, Barry
    Univ Iowa, Div Cardiovasc Med, Iowa City, IA USA;Univ Iowa, Abboud Cardiovasc Res Ctr, Iowa City, IA USA.
    Lotta, Luca A.
    Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
    Lovering, Ruth C.
    UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England.
    Luan, Jian'an
    Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
    Magnusson, Patrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
    Margulies, Kenneth B.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
    Maerz, Winfried
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
    Melander, Olle
    Lund Univ, Dept Internal Med, Clin Sci, Malmo, Sweden;Skane Univ Hosp, Malmo, Sweden.
    Mordi, Ify R.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Morgan, Thomas
    Novartis Inst Biomed Res, Cambridge, MA USA;Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
    Morris, Andrew D.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
    Morris, Andrew P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
    Morrison, Alanna C.
    Univ Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
    Nagle, Michael W.
    Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Nelson, Christopher P.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
    Niessner, Alexander
    Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Vienna, Austria.
    Niiranen, Teemu
    Natl Inst Hlth & Welf, Helsinki, Finland;Turku Univ Hosp, Dept Med, Turku, Finland;Univ Turku, Turku, Finland.
    O'Donoghue, Michelle L.
    Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA.
    Owens, Anjali T.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
    Palmer, Colin N. A.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Parry, Helen M.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Perola, Markus
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Portilla-Fernandez, Eliana
    Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, Div Vasc Med & Pharmacol, Rotterdam, Netherlands.
    Psaty, Bruce M.
    Univ Washington, Dept Med Epidemiol & Hlth Serv, Seattle, WA 98195 USA;Kaiser Permanente Washington, Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.
    Rice, Kenneth M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Romaine, Simon P. R.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
    Rotter, Jerome I.
    Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90509 USA.
    Salo, Perttu
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Helsinki, Finland.
    van Setten, Jessica
    Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands.
    Shalaby, Alaa A.
    Univ Pittsburgh, Med Ctr, Dept Med, Div Cardiol, Pittsburgh, PA USA;VA Pittsburgh HCS, Pittsburgh, VA USA.
    Smelser, Diane T.
    Geisinger, Dept Mol & Funct Genom, Danville, PA USA.
    Smith, Nicholas L.
    Kaiser Permanente Washington, Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;Dept Vet Affairs Off Res & Dev, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA.
    Stender, Steen
    Copenhagen Univ Hosp, Dept Clin Biochem, Copenhagen, Denmark.
    Stott, David J.
    Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
    Svensson, Per
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden;Soder Sjukhuset, Dept Cardiol, Stockholm, Sweden.
    Tammesoo, Mari-Liis
    Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
    Taylor, Kent D.
    Harbor UCLA Med Ctr, LABiomed, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90502 USA.
    Teder-Laving, Maris
    Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
    Teumer, Alexander
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
    Thorgeirsson, Gudmundur
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Natl Univ Hosp Iceland, Landspitali, Dept Internal Med, Div Cardiol, IS-101 Reykjavik, Iceland.
    Thorsteinsdottir, Unnur
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Dept Med, Fac Med, Saemundargata 2, IS-101 Reykjavik, Iceland.
    Torp-Pedersen, Christian
    Aalborg Univ Hosp, Dept Epidemiol & Biostat, Aalborg, Denmark;Aalborg Univ Hosp, Dept Hlth Sci & Technol, Aalborg, Denmark;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
    Trompet, Stella
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands;Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands.
    Tyl, Benoit
    Servier Cardiovasc Ctr Therapeut Innovat, Translat & Clin Res, 50 Rue Carnot, F-92284 Suresnes, France.
    Uitterlinden, Andre G.
    Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.
    Veluchamy, Abirami
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Voelker, Uwe
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
    Voors, Adriaan A.
    Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02118 USA.
    Wang, Xiaosong
    Novartis Inst Biomed Res, Cambridge, MA USA.
    Wareham, Nicholas J.
    Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
    Waterworth, Dawn
    GlaxoSmithKline, Human Genet, Collegeville, PA USA.
    Weeke, Peter E.
    Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.
    Weiss, Raul
    Ohio State Univ, Med Ctr, Dept Internal Med, Div Cardiovasc Med, Columbus, OH 43210 USA.
    Wiggins, Kerri L.
    Univ Washington, Dept Med, Seattle, WA USA.
    Xing, Heming
    Novartis Inst Biomed Res, Cambridge, MA USA.
    Yerges-Armstrong, Laura M.
    GlaxoSmithKline, Human Genet, Collegeville, PA USA.
    Yu, Bing
    Univ Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
    Zannad, Faiez
    Univ Lorraine, CHU Nancy, INSERM, F-54500 Nancy, France;Inst Lorrain Coeur & Vaisseaux, INI CRCT F CRIN, F-54500 Nancy, France.
    Zhao, Jing Hua
    Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
    Hemingway, Harry
    UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
    Samani, Nilesh J.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
    McMurray, John J. V.
    Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
    Yang, Jian
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
    Visscher, Peter M.
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
    Newton-Cheh, Christopher
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
    Malarstig, Anders
    Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden;Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA.
    Holm, Hilma
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Lubitz, Steven A.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA.
    Sattar, Naveed
    Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
    Holmes, Michael V.
    Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England;Univ Oxford, Big Data Inst, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Big Data Inst, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England;Oxford Univ Hosp, Oxford Biomed Res Ctr, Natl Inst Hlth Res, Oxford, England.
    Cappola, Thomas P.
    Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
    Asselbergs, Folkert W.
    UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England;Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands.
    Hingorani, Aroon D.
    UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England.
    Kuchenbaecker, Karoline
    UCL, Div Psychiat, London W1T 7NF, England;UCL, Genet Inst, London WC1E 6BT, England.
    Ellinor, Patrick T.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA.
    Lang, Chim C.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland.
    Stefansson, Kari
    Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Dept Med, Fac Med, Saemundargata 2, IS-101 Reykjavik, Iceland.
    Smith, J. Gustav
    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden;Skane Univ Hosp, Lund, Sweden;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden;Lund Univ, Ctr Diabet, Lund, Sweden.
    Vasan, Ramachandran S.
    NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA;Boston Univ, Sch Med, Dept Med, Sect Cardiol, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Sect Prevent Med, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Sect Epidemiol, Boston, MA 02118 USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Cardiol, Boston, MA USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Prevent Med, Boston, MA USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Epidemiol, Boston, MA USA.
    Swerdlow, Daniel I.
    UCL, Inst Cardiovasc Sci, London, England.
    Lumbers, R. Thomas
    UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England.
    Abecasis, Goncalo
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Backman, Joshua
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Bai, Xiaodong
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Balasubramanian, Suganthi
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Banerjee, Nilanjana
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Baras, Aris
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Barnard, Leland
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Beechert, Christina
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Blumenfeld, Andrew
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Cantor, Michael
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Chai, Yating
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Coppola, Giovanni
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Damask, Amy
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Dewey, Frederick
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Economides, Aris
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Eom, Gisu
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Forsythe, Caitlin
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Fuller, Erin D.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Gu, Zhenhua
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Gurski, Lauren
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Guzzardo, Paloma M.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Habegger, Lukas
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Hahn, Young
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Hawes, Alicia
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    van Hout, Cristopher
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Jones, Marcus B.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Khalid, Shareef
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Lattari, Michael
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Li, Alexander
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Lin, Nan
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Liu, Daren
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Lopez, Alexander
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Manoochehri, Kia
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Marchini, Jonathan
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Marcketta, Anthony
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Maxwell, Evan K.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    McCarthy, Shane
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Mitnaul, Lyndon J.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    O'Dushlaine, Colm
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Overton, John D.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Padilla, Maria Sotiropoulos
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Paulding, Charles
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Penn, John
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Pradhan, Manasi
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Reid, Jeffrey G.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Schleicher, Thomas D.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Schurmann, Claudia
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Shuldiner, Alan
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Staples, Jeffrey C.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Sun, Dylan
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Toledo, Karina
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Ulloa, Ricardo H.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Widom, Louis
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Wolf, Sarah E.
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Yadav, Ashish
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Ye, Bin
    Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.
    Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure2020In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 11, no 1, article id 163Article in journal (Refereed)
    Abstract [en]

    Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.

  • Älvebratt, Linn
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Johansson, Nadja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Pojkars och flickors skolprestationer inom berättande texter: En granskning av bedömningarna från nationella provet delprov F2020Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie syftar till att undersöka om lärares bedömning av texter skrivna av pojkar och flickor, inom den berättande genren på det nationella provet år 2015/2016 i svenska delprov F skiljer sig kvalitetsmässigt och hur genus påverkar lärarens bedömning. Vidare syftar studien till att undersöka hur genren berättande text används av pojkar och flickor. Detta undersöks genom två olika analyser, en utifrån bedömningsanvisningarna för nationella provet 2015/2016 samt genom en genreanalys. Det material som analyserats är 52 elevtexter från delprov F, 26 texter från pojkar och 26 från flickor. Analysen utifrån bedömningsanvisningarna delas in i tre kategorier där samtliga elevtexter placerats in i de olika kategorierna. Genreanalysen utgår från två genrer inom berättelse familjen, personligt återgivande genre och narrativ genre. Genusperspektivet och genrepedagogiken är studiens teoretiska utgångspunkter. Genusperspektivet används för att förklara orsaker och samband till att flickor och pojkar presterar olika i skolan. Resultatet visar att det råder skillnader i lärares bedömningar av eleverna beroende på deras kön, att flickor bedöms generösare än pojkar. Samt att det råder föreställningar om att flicktexter är bättre kvalitetsmässigt än pojktexter. Ur ett genrepedagogiskt perspektiv framkommer det att en möjlig orsak är att flickor följer berättelsestrukturen i större utsträckning då den berättande genren anses som icke-maskulin. Det är pojkar som oftast använder sig av den personligt återgivande genren medan flickor oftast skriver inom den narrativa genren. I studien framkommer det att elever som skriver inom den narrativa genren i större utsträckning når kravnivån än de elever som skrivit inom den personligt återgivande genren.

  • Johansson, Sanna
    et al.
    Institutionen för pedagogik, didaktik och utbildningsstudier.
    Samuelsson, Sofia
    Institutionen för pedagogik, didaktik och utbildningsstudier.
    Nationella prov + läromedel + förmågor = Sant?2020Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien har varit att genom att analysera läromedel och nationella prov belysa hur ett läromedel och nationella proven i svenska årskurs 3 förhåller sig till läroplanens formuleringar om förmågor i svenskämnet för årskurs 3. Vidare har studien syftat till att undersöka huruvida samstämmighet eller avsaknad av samstämmighet återfinns mellan läroplanen i svenska årskurs 3, nationella prov och läromedel. Syftet mynnade ut i tre frågeställningar som löd: Vilka förmågor i svenska åk 3 prövas och prövas inte i de nationella proven och ett läromedel i svenska för årskurs 3? Hur prövas förmågorna i svenska åk 3 i de nationella proven och hur förekommer förmågorna i ett läromedel i svenska för årskurs 3? På vilket sätt finns det eller finns det inte samstämmighet mellan de nationella proven i svenska, ett läromedel i svenska och kursplanens förmågor i svenska för  årskurs 3? I analysen av läromedlet Forma språket och de nationella proven användes en kvalitativ innehållsanalys. Analysen gjordes med hjälp av en tabell där meningsbärande enheter, underkategori och tema fylldes i. Den teori som användes i studien var constructive alignment med fokus på John Biggs samstämmighetsmodell. Modellen inkluderar tre faktorer för att skapa samstämmighet. De faktorer som användes i studien var hämtade från samstämmighetsmodellen men benämndes i studien som “de fem förmågorna”, “läromedel” och “nationella proven”. Resultatet visade på att alla fem förmågorna prövas i läromedlet medan fyra förmågor prövas i nationella proven. Förmågan som inte prövas i de nationella proven är att söka information. Sammanfattningsvis prövas och förekommer förmågorna i nationella proven och läromedlet genom sju olika kategorier som är högläsningsstrukturer, läsförståelse, metakunskap, textens innehåll, textens form, stödstrukturer och söka information. Resultatet visade även på att det fanns samstämmighet mellan läromedlet, nationella proven och förmågorna då hänsyn tas till förmågorna i båda materialen samt att läromedlet förbereder eleverna inför nationella proven då mycket av det som förekommer i läromedlet prövas i nationella proven.

  • Jammal, Salma
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Skilsmässor bland framgångsrika kvinnor: En kvalitativ studie om heterosexuella pars förhållanden när kvinnan har högre ekonomi2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats presenterar framgångsrika heterosexuella kvinnor som har i någon form separerats eller upplevd skilsmässa. Uppsatsen studerar vad orsaken av separationen kan bero på, då flera studier menar att chansen för skilsmässa hos par med en framgångsrik kvinna ökar, desto mer framgång en kvinna blir eller har en högre arbetsinkomst än hennes partner. Uppsatsen lyfter upp tre frågeställningar som fokuserar på dynamiken i relationen, kvinnan syn på följden av hennes framgång och vad hon hävdar är orsaken för separation. Uppsatsen använder en kvalitativ metod genom att intervjua sju framgångsrika kvinnor som har separerat från sina partners. Detta för att få en närmare bild på hur framgång hos kvinnan påverkar dynamiken och maktordningen i hennes relation samt hur konflikter uppstår. Intervjun består av semistrukturerade intervjufrågor, eftersom den upplevdes mest lämpligt till denna studie. Vidare använder uppsatsen den hermeneutiska ansatsen, som bland annat fokuserar på att tolka och finna dolda sammanhang. Uppsatsen fördjupar sig i kvinnornas syn på patriarkal, tradition och samhällsnormer, för att finna orsak till skilsmässa i deras liv. Uppsatsen belyser flera aspekter som kan vara orsaken till skilsmässa. Flera av respondenterna menar att; det fortfarande anses vara ovanligt när en kvinna lägger flera timmar på arbete som är utanför hemmet och att det uppstår konkurrens mellan paren. Slutsatsen med denna uppsats är att medan stora framsteg har uppnåtts för att få kvinnan mer accepterad på arbetsmarknaden, så är synen på henne som underordnad i privatlivet fortfarande oförändrat på grund av kultur och gamla traditioner.  

  • Wallin, Johan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Jatko Nilsson, Tom
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Annonsering av nyemissioner: En jämförelse mellan avvikelseavkastningen vid riktade- och företrädesemissioner samt förklarande faktorer2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker om det finns en skillnad i kortsiktig avvikelseavkastning mellan riktade och företrädesemissioner vid annonsering av nyemission. Utöver det undersöks även faktorer som kan påverka avvikelseavkastningen. Dessa faktorer är syftet med emissionen och emissionsbeloppet. Det som motiverar studien är motsägande resultat i tidigare forskning och en brist av undersökningar på den svenska marknaden. Studien genomförs på svenska bolag listade på Nasdaq Stockholm under åren 2017-2019 och omfattar totalt 90 nyemissioner. Metoden som används är en eventstudie och regressionsanalys. Studiens resultat visar att både företrädesemissioner och riktade emissioner har en negativ avvikelseavkastning vid annonsering av nyemission. Företrädesemissioner har en mer negativ avvikelseavkastning än riktade emissioner, men skillnaden kan bero på andra faktorer än emissionstyp. Syftet med emissionen påverkar avvikelseavkastningen negativt vid defensiva syften och positivt vid offensiva syften. Emissionsbeloppet har en negativ påverkan på avvikelseavkastningen. Resultaten stämmer till stor del överens med tidigare forskning.

  • Hahne, Hampus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity.
    Improvement of a load circuitfor power consumption within ananogrid application2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The transistion from fossile fuels to renewable energy goes in a rapidpace. A way to contribute to this process is the nanogrid applicationwith renewable energy sources. A prototyp of this application islocated on the roof of house 8 at Ångström laboratory. The ambition isto connect a wind power source to a battery bank via a MPPT device.Since the MPPT have limitations is a load circuit for power consumptionnecessary, which in its present form are not functional. Improvementsare made for the load circuit togheter with computional simulations.Necessary experimental measurements are done to evaluate itsfunctionality. The experimental results shows alignment with simulationand the load circuit can be inserted into the nanogrid system. Theinteraction between the MPPT device and the load circuit and indeed thewhole system is left as a future work.

  • Nadifa, Ali
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Jämställdhet -mål eller medel?: En studie av legitimeringen av jämställdhet i Sverigedemokraternas politik2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Olsson, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Inkomstfördelning, strejker och industrialisering i Sverige 1870–1900: regressionsanalys med nya mikrodata2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    This study examines the distribution of income in Sweden 1870–1900, alongside with the historical labour strikes during the same period. The income data is extracted from old tax records at the National Archive of Sweden, and the dataset of historical strikes was created by the economist Axel Raphael by analyzing newspapers from this time. I have combined the two datasets, processed them accordingly, and calculated descriptive statistics, in order to execute linear regression analysis. The descriptive statistics shows that the gini coefficients decreased nationally, and in every county, but the coefficients from 1870 are not particularly well correlated with the coefficients from 1900. The results from the regression analysis show that the strike concentration in each county, controlled for by the gini coefficient from 1870, increased the expected values of the gini coefficients from 1900. This model is then further controlled for by the level of industrialization in each county, and this new independent variable proves to have been the underlying variable as to why the strikes correlated with the increased inequality. The level of industrialization maintains its significance in all models, with a positive b-coefficient in relation to the gini coefficients from 1900, and the mechanism for this result is quite plausible. These results are then discussed as a context for the situation in some of today’s developing countries.

  • Elverö, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Förstelärarreformen utifrån New Public Management2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Öhlund, Maja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Hur påverkar arbetsplatsen uttaget av föräldraförsäkringen: En kvalitativ intervjustudie om hur normer påverkar uttaget av föräldraförsäkringen2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte är att att öka förståelsen för implementeringen av föräldraförsäkringen. Uttaget av föräldraförsäkringen skiljer sig mellan män och kvinnor och genom att undersöka om det finns könade normer (kopplat till föräldraförsäkringen) som påverkar män och kvinnor på olika sätt på arbetsplatsen, samt hur normer och informella regler på arbetsplatsen påverkar föräldrars uttag av föräldraförsäkringen, kompletteras tidigare studier på området. Studiens teoretiska ramverk utgörs av Feministisk Institutionalism och genom att intervjua föräldrar angående normer på sina arbetsplatser bidrar studien med kunskap om förldraförsäkringens informella regelverk. Studiens resultat ger en kvalitativ beskrivning om hur normer kring föräldraförsäkring är olika för män och kvinnor på arbetsplatsen. Kvinnor bemöts som den primära förälderns medan männen blir bemötta som den primära förvärvsarbetaren.

  • Scocco, Therese
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    What Can a Small State Do?: Swedish Leadership in Sexual and Reproductive Health and Rights in the United Nations2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In the face of a global headwind against sexual and reproductive health and rights (SRHR), led by the Trump administration, Sweden has worked together with like-minded countries to keep ground in SRHR issues. The purpose of this thesis is to increase the knowledge about what strategies are available for small states to influence global policies in international organizations. Looking at the period of 2017–2019, this thesis aims to answer the question: “Which strategies has Sweden used to establish leadership in sexual and reproductive health and rights issues in the United Nations?” The analysis through the framework of leadership theory shows that Sweden utilized all strategies investigated (ideational, structural, directional and instrumental), acting like an efficient leader. Despite previous research assuming small states would rely less on traditional sources of power, Sweden actively deployed its structural resources, covering the gap after the Trump administration defunded the United Nations Population Fund. As a result of Sweden’s and other actors’ efforts, agreed language was protected at the Commission on Population and Development.

  • Wingård, Olov
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    “Samtidigt i Sverige – arkitekturens u-land”: En ideologi- och argumentationsanalys av Arkitekturupproret2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Bäckman, Joel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Saffronisation or moderation?: A comparative case study of the Bharatiya Janata Party between two terms2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Cöllen, Sebastian
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    Metaforens historicitet: En kognitionslingvistisk undersökning av medeltida bildspråk2020In: Årsbok Kungl. Humanistiska Vetenskaps-Samfundet i Uppsala = Annales Societatis litterarum humaniorum regiae Upsaliensis, ISSN 0349-0416, Vol. 2018-2019, p. 201-213Article in journal (Other academic)
  • Pérez-Penichet, Carlos
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Architecture and Computer Communication.
    Piumwardane, Dilushi
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Rohner, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Architecture and Computer Communication.
    Voigt, Thiemo
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Architecture and Computer Communication.
    A Fast Carrier Scheduling Algorithm for Battery-free Sensor Tags in Commodity Wireless Networks2020Conference paper (Refereed)
    Abstract [en]

    New battery-free sensor tags that interoperate with unmodified standard IoT devices and protocols can extend a sensor network’s capabilities in a scalable and cost-effective manner. The tags achieve battery-free operation through backscatter-related techniques, while the standard IoT devices avoid additional dedicated infrastructure by providing the unmodulated carrier that tags need to communicate. However, this approach requires coordination between devices transmitting, receiving and generating carrier, adds extra latency and energy consumption to already constrained devices, and increases interference and contention in the shared spectrum. We present a scheduling mechanism that optimizes the use of carrier generators, minimizing any disruptions to the regular nodes. We employ timeslots to coordinate the unmodulated carrier while minimizing latency, energy consumption and overhead radio emissions. We propose an efficient scheduling algorithm that parallelizes communications with battery-free tags when possible and shares carriers among multiple tags concurrently. In our evaluation we demonstrate the feasibility and reliability of our approach in testbed experiments. We find that we can significantly reduce the excess latency and energy consumption caused by the addition of sensor tags when compared to sequential interrogation. We show that the gains tend to improve with the network size and that our solution is close to optimal on average.

  • Maxia, Alexander James
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    The Principles of a Stable Community: 90 Years of Structured Integration in a Culturally Diverse New Town in Sardinia2020Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    An atom, a cell and a solar system have very little in common. My science teachers from high school will confirm that I am very far from being an expert on the matter but nontheless, I have studied these three systems in separate classes: chemistry, biology and astronomy. So I believe they must be fairly unrelated from each other! All they have in common is that they are studied through a magnifying lens by people who are better than me in maths. But onceyou look through the lens, you should see a main body and smaller objects rotating around it. The electrons around the protons, the cytoplasm around the nucleus and the planets around the sun. The key element they have in common is structure. Perhaps this is too abstract, even for an abstract, so let’s bring things back to earth.

    Structures play a fundamental role in shaping the world around us and this thesis aims to understand to what extent and how they influence people’s daily lives. The case study is based on the new town of Arborea in Sardinia, originally designed and owned by a private company to make an efficient and innovative industrial food production system. It aims to show how the ambition to produce was ingrained in the buildings and societal structures and how the surroundings affected the people who moved there. Everything was studied in detail:from the road grid to the houses, the church’s positioning and even selecting people from the north of Italy who were deemed most suitable to work there. The use of structuration theory will be key to uncover the different layers and relations that still shape the community today. 35.000 cows, 3800 people, a history of cultural clashes, a productive system, a very fascist background, a ’sex patrolling’ priest, a dozen volunteering organisations will all feature in thethesis and together enable to draw a picture of the new town.

  • Hasselgren, Kristina
    et al.
    Linkoping Univ, Dept Surg, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Isaksson, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    Ardnor, Bjarne
    Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.
    Lindell, Gert
    Lund Univ, Dept Surg, Clin Sci, Lund, Sweden.
    Rizell, Magnus
    Univ Gothenburg, Transplant Inst, Sahlgrenska Acad, Gothenburg, Sweden.
    Stromberg, Cecilia
    Karolinska Inst, Dept Clin Sci Intervent & Technol CLLNTEC, Div Surg, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Loftas, Per
    Linkoping Univ, Dept Surg, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Bjornsson, Bergthor
    Linkoping Univ, Dept Surg, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Sandstrom, Per
    Linkoping Univ, Dept Surg, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Liver resection is beneficial for patients with colorectal liver metastases and extrahepatic disease2020In: Annals of Translational Medicine, ISSN 2305-5839, E-ISSN 2305-5847, Vol. 8, no 4, article id 109Article in journal (Refereed)
    Abstract [en]

    Background: Liver metastases are the most common cause of death for patients with colorectal cancer and affect up to half of the patients. Liver resection is an established method that can potentially be curative. For patients with extrahepatic disease (EHD), the role of liver surgery is less established. Methods: This is a retrospective study based on data from the national quality registry SweLiv. Data were obtained between 2009 and 2015. SweLiv is a validated registry and has been in use since 2009, with coverage above 95%. Patients with liver metastases and EHD were analyzed and cross-checked against the national death cause registry for survival analysis. Results: During the study period, 2,174 patients underwent surgery for colorectal liver metastases (CRLM), and 277 patients with EHD were treated with resection or ablation. The estimated median survival time for the entire cohort from liver resection/ablation was 40 months (95% CI, 32-47). The survival time for patients treated with liver resection was 45 months compared to 26 months for patients treated with ablation (95% CI 38-53, 18-33, P=0.001). A subgroup analysis of resected patients revealed that the group with pulmonary metastases had a significantly longer estimated median survival (50 months; 95 % CI, 39-60) than the group with lymph node metastases (32 months; 95% CI, 7-58) or peritoneal carcinomatosis (28 months; 95% CI, 14-41) (P=0.022 and 0.012, respectively). Other negative prognostic factors were major liver resection and nonradical liver resection. Conclusions: For patients with liver metastases and limited EHD, liver resection results in prolonged survival compared to what can be expected from chemotherapy alone.

  • Yordanova, Emiliya
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Voros, Zoltan
    Austrian Acad Sci, Space Res Inst, Graz, Austria;Res Ctr Astron & Earth Sci, Geodet & Geophys Inst, Sopron, Hungary.
    Raptis, Savvas
    Royal Inst Technol, Space & Plasma Phys, Stockholm, Sweden.
    Karlsson, Tomas
    Royal Inst Technol, Space & Plasma Phys, Stockholm, Sweden.
    Current Sheet Statistics in the Magnetosheath2020In: FRONTIERS IN ASTRONOMY AND SPACE SCIENCES, ISSN 2296-987X, Vol. 7, article id 2Article in journal (Refereed)
    Abstract [en]

    The magnetosheath (MSH) plasma turbulence depends on the structure and properties of the bow shock (BS). Under quasi-parallel (Q(||)) and quasi-perpendicular (Q(perpendicular to)) BS configurations the electromagnetic field and plasma quantities possess quite distinct behavior, e.g., being highly variable and structured in the Q(||) case. Previous studies have reported abundance of thin current sheets (with typical scales of the order of the plasma kinetic scales) in the Q(||) MSH, associated with magnetic reconnection, plasma heating, and acceleration. Here we use multipoint observations from Magnetospheric MultiScale (MMS) mission, where for the first time a comparative study of discontinuities and current sheets in both MSH geometries at very small spacecraft separation (of the order of the ion inertial length) is performed. In Q(||) MSH the current density distribution is characterized by a heavy tail, populated by strong currents. There is high correlation between these currents and the discontinuities associated with large magnetic shears. Whilst, this seems not to be the case in Q(perpendicular to) MSH, where current sheets are virtually absent. We also investigate the effect of the discontinuities on the scaling of electromagnetic fluctuations in the MHD range and in the beginning of the kinetic range. There are two (one) orders of magnitude higher power in the magnetic (electric) field fluctuations in the Q(||) MSH, as well as different spectral scaling, in comparison to the Q(perpendicular to) MSH configuration. This is an indication that the incoming solar wind turbulence is completely locally reorganized behind Q(perpendicular to) BS while even though modified by Q(||) BS geometry, the downstream turbulence properties are still reminiscent to the ones upstream, the latter confirming previous observations. We show also that the two geometries are associated with different temperature anisotropies, plasma beta, and compressibility, where the Q(perpendicular to) MSH is unstable to mostly mirror mode plasma instability, while the Q(||) MSH is unstable also to oblique and parallel fire-hose, and ion-cyclotron instabilities.

  • Rudström, Hedvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Entrepreneurialism in Uppsala: Public - Private partnership and the construction of a safe public space2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Entrepreneurial urbanism is the narrative of the modern city, and more and more the city is constructed as a commodity to be competitive on the market and attract investment. City managers and developers are using different strategies to market and construct the city as attractive and vibrant. One characteristic of the entrepreneurial city is the use of public-private partnerships. This thesis explores the public-private partnership project in Uppsala inner city where private security guards are, since 2017, patrolling public space.  

    Urban development narratives in Uppsala are promoting the city as attractive and as a living room for the residents, and it is through this conceptualisation they want to protect the inner city. This paper is, through the theoretical framework of Laclau and Mouffe´s Discourse Theory, analysing material focusing on the articulatory practices of the public-private partnership and the discursive construction of “the city”. The operationalization of Discourse theory with the theoretical framework presented in this paper produces a critique of the entrepreneurial and neo-liberal agenda in Uppsala. Focusing on the public-private partnership project and the control of public space, as well as the entrepreneurial narrative of the partnership, the paper argues for a radicalisation of urban politics and the creation of a plural city. 

  • Public defence: 2020-04-17 09:00 Sal IV, Uppsala
    Aarnio, Riina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology.
    Self-sampling for HPV testing in primary cervical screening: Including clinical and health economic aspects2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV testing has higher sensitivity for high-grade cervical intraepithelial neoplasia (CIN2+) than cytology, resulting in more effective screening. As HPV testing also offers an opportunity for self-sampling, it could serve as an even more effective and cost-effective method of cervical screening.

    First, we compared repeated self-sampling for HPV testing with Pap smear cytology in detection of CIN2+ in primary cervical screening for women aged 30–49 years (n=36 390). We found a more than twofold higher detection rate of CIN2+ and a fourfold higher detection rate of CIN2 with self-sampling compared with cytology. However, no difference was seen between the arms in the detection rate of CIN3+. It thus seems that CIN is detected at an earlier stage with self-sampling than with cytology, but the impact of this needs to be further explored.

    Second, as management of HPV-positive women with normal cytology results is a challenge, we wanted to evaluate the proportion of cases of histological CIN2+ in these women. In this prospective study we performed LEEP and found that 15% (6/40) of the women had undetected CIN2+. These findings can be used in counseling women about the risk of cervical cancer and helping clinicians in decisions on management.

    Third, we performed a cost-effectiveness analysis on the same study population as in Study I. Self-sampling for HPV testing resulted in a higher participation rate and more detected cases of CIN2+ at a lower cost and was regarded as more cost-effective than Pap smear cytology in cervical screening. These results can guide policy-makers when planning future screening programs.

    Fourth, we compared self-sampling with sampling by medical professionals for HPV testing in detection of CIN2+, using a combination of an FTA card as storage medium and a PCR-based HPV test (hpVIR) in women aged 30–60 years (n=11 951). No difference in the detection rates of histological CIN2+ was found between the arms.

    Taken together, self-sampling resulted in a higher participation rate than sampling by medical professionals in cervical screening and that triage with repeated self-sampling resulted in high compliance and detection rate of CIN2+. As repeated self-sampling for HPV testing was also cost-effective, it could serve as an attractive alternative in the development of future cervical screening programs. More research is needed on how to refine the management of HPV-positive women by self-sampling only.

    List of papers
    1. Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology
    Open this publication in new window or tab >>Randomised study shows that repeated self-sampling and HPV test has more than two-fold higher detection rate of women with CIN2+ histology than Pap smear cytology
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    2018 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 118, no 6, p. 896-904Article in journal (Refereed) Published
    Abstract [en]

    Background:

    This randomised study compared the detection rate of cervical intraepithelial neoplasia-positive (CIN2+) based on histology in women performing repeated self-sampling of vaginal fluid (VF) for human papillomavirus (HPV) test with a control group following the ordinary screening by Pap smear cytology.

    Methods:

    36390 women aged 30–49 years scheduled for invitation to organised screening were randomised in two groups, one to perform self-sampling of VF for HPV test (n=17 997, HPV arm) and the other group to perform screening by PAP smear cytology (n=18 393, control arm). HPV positive women in the HPV arm repeated the self-sampling and the HPV test on average 4.4 months later and those with two consecutive positive HPV tests were referred to colposcopy. Outcome was CIN2+ based on histology during 18-month follow-up.

    Results:

    Participation rate was 47% in the HPV arm and 39% in the control arm. The HPV prevalence in the first self-sampling was 6.9%, and 71% of these women were HPV positive in their second test. For the per-protocol approach, cumulative prevalence of histological CIN2+ in the HPV arm was 20.2 per 1000 women screened as compared to 10.8 in the control arm. The cumulative prevalence of CIN2+ diagnosed per 1000 years screened was 160.8 in the HPV arm as compared with 25.4 in the control arm.

    Conclusions:

    Repeated self-sampling of VF and HPV test had more than a two-fold higher discovery rate of CIN2+ per 1000 women screened as compared with PAP smear cytology.

    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:uu:diva-367087 (URN)10.1038/bjc.2017.485 (DOI)000427945800030 ()29438367 (PubMedID)
    Funder
    Swedish Foundation for Strategic Research Swedish Cancer SocietySwedish Society for Medical Research (SSMF)
    Available from: 2018-11-28 Created: 2018-11-28 Last updated: 2020-03-18Bibliographically approved
    2. Diagnostic excision of the cervix in women over 40 years with human papilloma virus persistency and normal cytology
    Open this publication in new window or tab >>Diagnostic excision of the cervix in women over 40 years with human papilloma virus persistency and normal cytology
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    2019 (English)In: European journal of obstetrics & gynecology and reproductive biology: X, ISSN 2590-1613, Vol. 3, article id 100042Article in journal (Refereed) Published
    Abstract [en]

    Objective: Persistent infection with human papillomavirus (HPV) is recognized as the main risk factor of cervical cancer. Investigation via cytology and colposcopy have lower sensitivity than HPV testing in the diagnosis of high-grade cervical intraepithelial neoplasia (CIN2+). Despite normal cytology and colposcopy findings women with persistent HPV infection have an increased risk of CIN2+. The aim of the study was to evaluate the proportion of histologically confirmed CIN2+ in women with persistent HPV infection and normal Pap smears.

    Study design: From April 2013 until March 2016 we prospectively recruited 91 women over 40 years with persistent HPV infection without any abnormalities in cytology. Of these, 40 women attended a gynecological examination including an HPV test, Pap smear, endocervical cytology, colposcopy with biopsies and diagnostic loop electrosurgical excision procedure (LEEP). Biopsy and LEEP samples were subjected to histological examination.

    Results: CIN2+ was verified by histological examination of the LEEP sample in 6/40 (15%) of the women. All the cytological samples were normal and none of the biopsies confirmed CIN2+. Only 19/40 women still had a persistent HPV infection at the study visit. None of the 21/40 women who had cleared their HPV infection at the study visit had CIN2+ in histology of the LEEP sample.

    Conclusions: A persistent HPV infection needs to be monitored despite normal Pap smears, since 6/40 (15%) women older than 40 years, was revealed to have an undiagnosed CIN2+ when LEEP was performed. Counseling women regarding the risk of cervical cancer and the expected effect of an eventual LEEP can help them to make an optimal informed choice.

    Keywords
    Cervical intraepithelial neoplasia, Colposcopy, Human papillomavirus, Loop electrical excision procedure, Transformation zone
    National Category
    Obstetrics, Gynecology and Reproductive Medicine
    Identifiers
    urn:nbn:se:uu:diva-400770 (URN)10.1016/j.eurox.2019.100042 (DOI)31404426 (PubMedID)
    Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-03-18Bibliographically approved
    3. Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study
    Open this publication in new window or tab >>Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background

    Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase population coverage and result in a more efficient strategy to identify women at risk of developing cervical cancer. Our objective was to assess whether repeated self-sampling for HPV testing is cost-effective in comparison with Pap smear cytology for detection of cervical intraepithelial neoplasia grade 2 or more (CIN2+) in increasing participation rate in primary cervical screening.

    Methods

    A cost-effectiveness analysis (CEA) was performed on data from a previously published randomized clinical study including 36 390 women aged 30–49 years. Participants were randomized either to perform repeated self-sampling of vaginal fluid for HPV testing (n = 17 997, HPV self-sampling arm) or to midwife-collected Pap smears for cytological analysis (n = 18 393, Pap smear arm).

    Results

    Self-sampling for HPV testing led to 1633 more screened women and 107 more histologically diagnosed CIN2+ at a lower cost vs. midwife-collected Pap smears (€ 228 642 vs. € 781 139). 

    Conclusions

    This study projected that repeated self-sampling for HPV testing increased participation and detection of CIN2+ at a lower cost than midwife-collected Pap smears in primary cervical screening. Offering women a home-based self-sampling may therefore be a more cost-effective alternative than clinic-based screening.

     

    Keywords
    Self-sampling, HPV testing, primary cervical screening, cost-effectiveness, CIN2+, precancerous lesion, cervical cancer
    National Category
    Obstetrics, Gynecology and Reproductive Medicine
    Research subject
    Obstetrics and Gynaecology
    Identifiers
    urn:nbn:se:uu:diva-405549 (URN)
    Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2020-03-12Bibliographically approved
    4. Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: a randomized study
    Open this publication in new window or tab >>Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: a randomized study
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Primary screening with human papillomavirus (HPV) test is more effective in reducing cervical cancer incidence than cytology and it also offers the opportunity to self-sample. We conducted a randomized study to compare vaginal self-sampling with cervical sampling by medical professionals for HPV testing concerning prevalence of HPV and detection of cervical intraepithelial neoplasia (CIN) of grade 2 or worse (CIN2+)  or grade 3 or worse (CIN3+) in primary screening. In total, 11 951 women aged 30–60 years were randomized into two groups, 5961 for self-sampling (SS arm) and 5990 for sampling by medical professionals (SMP arm). Sampling was performed with a Rovers®Viba-brush in the SS arm and a cytobrush in the SMP arm. All samples were applied to an indicating FTA elute card and analyzed for HPV using a clinically validated real-time PCR test (hpVIR). All HPV-positive women performed repeated sampling about six months later using the same procedure as used initially. All HPV-positive women in the second sampling were referred to colposcopy. HPV prevalence in the first test did not differ between the SS arm (6.8%, 167/2466) and the SMP arm (7.8%, 118/1519) (p=0.255). The prevalence of CIN2+ per 1000 screened women was 17 (43/2466 × 1000) (95%CI 13–24) in the SS arm and 21 (32/1519 × 1000) (95%CI 15–30) in the SMP arm. For CIN3+, the prevalence per 1000 screened women was 14 (35/2466 × 1000) (95%CI 10–20) in the SS arm and 15 (23/1519 × 1000) (95%CI 10–23) in the SMP arm.  In conclusion, self-sampling and sampling by medical professionals showed the same prevalence of HPV and detection rate of CIN2+ and CIN3+ in histology.

    Novelty and Impact

    Offering self-sampling in primary cervical screening results in similar rates of HPV prevalence and detection of CIN2+ and CIN3+ compared with sampling by medical professionals when using an FTA card as storage medium and PCR-based HPV test (hpVIR). Considering health-economic aspects, resources should be directed towards self-sampling as a first choice for primary cervical screening, with careful follow-up of this strategy.

    Keywords
    Self-sampling, HPV test, Primary cervical screening
    National Category
    Obstetrics, Gynecology and Reproductive Medicine
    Research subject
    Obstetrics and Gynaecology
    Identifiers
    urn:nbn:se:uu:diva-405547 (URN)
    Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2020-03-12Bibliographically approved
  • May, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Narratives in the spotlight: an analysis of two positions in sustainability2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    People’s view of the world can cause them to make decisions that may not be sensible or based on incomplete information. A way to rectify this problem is by drawing upon ideas that are presented within bestselling popular science publications, in this case relating to sustainable development. This thesis sets out to map two positions in sustainability, techno optimism (based around technological solutions for societal and ecological problems) and eco centrism (based around the importance and irreplaceability of natural capital). Four parameters were selected for analysis; overpopulation, energy, decentralization, and economy, to analyse the key ideas of the respective positions. A small number of texts were used, based on the prominence of the authors and their relevance to the field. The two positions were chosen for their similarities, and how others had attempted to combine them in the past. In addition, a chapter on the Sustainocene was added, an idea based around humans living sustainably within the environment; important due to including ideas from both positions. A similar concept, the arcology, was also included. Both concepts were discussed as a means of bridging the gap between eco centrism and techno optimism. It was found that there were some similarities between the two positions, although several important differences, mainly relating to the role of ecosystems and limits to growth. A future thesis would ideally further build on this one in discussing ways in which the two positions could be combined further within sustainable development.

  • Eidem, Aaron
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Dahlgren, Nicholas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hur påverkas finansiell prestation av hållbarhetsarbete?: En studie om svenska bolags ESG-betyg2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker sambandet mellan hållbarhetsarbete och den marknadsbaserade samt redovisningsbaserade finansiella prestationen hos svenska, börsnoterade bolag. Studiens observationer utgörs av bolag som är noterade vid Stockholmsbörsen åren 2017 och 2018. Hållbarhetsarbetet har bedömts genom att ta del av dels ESG Score, dels ESG Controversy Score (ESGC Score). Det första måttet utgör ett betyg som presenterar ett helhetsomdöme av bolagens samlade arbete inom parametrarna miljö, bolagsstyrning och hantering av sociala frågor. Det senare måttet mäter graden av negativ exponering i samband med ESG-relaterade kontroverser. Studien har företagits genom multipla regressionsanalyser där sambandet mellan ESG Score respektive ESGC Score och den finansiella prestationen har undersökts. Finansiell prestation har mätts genom användandet av de finansiella måtten Tobins Q och ROA. Resultaten uppvisar statistiskt säkerställda negativa samband mellan de finansiella måtten och ESG Score, vilket i viss mån motsäger forskningen, men kan förklaras av teorier såsom Shareholder Theory. Gällande ESGC Score uppvisas ett statistiskt säkerställt positivt samband med Tobins Q. Studien bidrar till forskningen genom att ESGC Score, enligt studieförfattarnas kännedom, inte undersökts på förevarande vis. 

  • Öhlund, Maja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Hur påverkar arbetsplatsen uttaget av föräldraförsäkringen: En kvalitativ intervjustudie om hur normer påverkar uttaget av föräldraförsäkringen2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte är att att öka förståelsen för implementeringen av föräldraförsäkringen. Uttaget av föräldraförsäkringen skiljer sig mellan män och kvinnor och genom att undersöka om det finns könade normer (kopplat till föräldraförsäkringen) som påverkar män och kvinnor på olika sätt på arbetsplatsen, samt hur normer och informella regler på arbetsplatsen påverkar föräldrars uttag av föräldraförsäkringen, kompletteras tidigare studier på området. Studiens teoretiska ramverk utgörs av Feministisk Institutionalism och genom att intervjua föräldrar angående normer på sina arbetsplatser bidrar studien med kunskap om förldraförsäkringens informella regelverk. Studiens resultat ger en kvalitativ beskrivning om hur normer kring föräldraförsäkring är olika för män och kvinnor på arbetsplatsen. Kvinnor bemöts som den primära förälderns medan männen blir bemötta som den primära förvärvsarbetaren.

  • Hedberg, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    En strid för det som borde vara: Viktor Rydberg som moderniseringskritiker 1891–18952012Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This dissertation deals with the critique of modernization in the late work of Viktor Rydberg (1828–1895). The primary objects of study are the novel Vapensmeden (”The Armourer”) and the essay ”Den hvita rasens framtid” (”The Future of the White Race”). The study combines perspectives from narrative, rhetorical and sociological theory and describes the fictive and non-fictive text as tools of resistance against the process of modernization.

    Rydberg’s later work has often been left uncommented by critics and literary historians. The novel Vapensmeden, for example, has been considered nostalgic and conservative, in contrast to Rydberg’s earlier poems and novels, widely read as progressive and idealistic. This study questions that view, while at the same time explaining its roots, through a detailed study of the changes in Rydberg’s fame and persona during the first century after his death. In order to describe how Rydberg’s work reached a mass audience during the first half of the twentieth century, this dissertation also includes a bibliography for the years 1896–2003.

    Rydberg’s ideological development in the 1880s and 1890s is interpreted as a consequence of his reluctance to accept a society created by the liberalism of his youth, which he felt had metamorphosed from an ideology of freedom to a defense of greed and destruction. This, however, does not mean that he had become a conservative, but rather a restless seeker of alternatives. In his last works, he made use of his reputation both as a poet and a novelist and as a well-read and respected academic. Every device, every possible effort was needed in order to control the forces of modernization. In fact, in Vapensmeden as well as in ”Den hvita rasens framtid”, Rydberg mixes fictional and academic writing, speaking from two positions at the same time.

  • Fäldt, Göran
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Sequential hyperon decays in the reaction e(+)e(-) -> Sigma(0)(Sigma)over-bar(0)2020In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 101, no 3, article id 033002Article in journal (Refereed)
    Abstract [en]

    We report on a study of the sequential hyperon decay Sigma(0) -> Lambda gamma; Lambda -> p pi(-) and its corresponding antihyperon decay. We derive a multidimensional and model-independent formalism for the case when the hyperons are produced in the reaction e(+)e(-) -> Sigma(0)(Sigma) over bar (0). Cross-section distributions are calculated using the folding technique. We also study sequential decays of single-tagged hyperons.

  • Öfverberg, Miriam
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Policyprofessionella i politiken: ett demokratiskt problem?: En studie om policyprofessionellas inflytande på kommunal nivå2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Cederwall, B.
    et al.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Liu, X.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Aktas, O.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Ertoprak, A.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden;Istanbul Univ, Fac Sci, Dept Phys, TR-34134 Istanbul, Turkey.
    Zhang, W.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Qi, C.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Clement, E.
    CEA DSM CNRS IN2P3, GANIL, Bd Henri Becquerel,BP 55027, F-14076 Caen 5, France.
    de France, G.
    CEA DSM CNRS IN2P3, GANIL, Bd Henri Becquerel,BP 55027, F-14076 Caen 5, France.
    Ralet, D.
    Univ Paris Saclay, Ctr Sci Nucl & Sci Mat, CNRS, IN2P3, F-91405 Orsay, France.
    Gadea, A.
    Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Valencia, Spain.
    Goasduff, A.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy.
    Jaworski, G.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy;Univ Warsaw, Heavy Ion Lab, Ul Pasteura 5A, PL-02093 Warsaw, Poland.
    Kuti, I.
    MTA Atomki, H-4001 Debrecen, Hungary.
    Nyako, B. M.
    MTA Atomki, H-4001 Debrecen, Hungary.
    Nyberg, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Palacz, M.
    Univ Warsaw, Heavy Ion Lab, Ul Pasteura 5A, PL-02093 Warsaw, Poland.
    Wadsworth, R.
    Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England.
    Valiente-Dobon, J. J.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy.
    Al-Azri, H.
    Rustaq Coll Educ, Dept Sci, Al Rustaq 329, Oman.
    Nyberg, A. Atac
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    Back, T.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden.
    de Angelis, G.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy.
    Doncel, M.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden;Univ Liverpool, Oliver Lodge Lab, Dept Phys, Liverpool L69 7ZE, Merseyside, England.
    Dudouet, J.
    Univ Lyon, IPN Lyon, CNRS, IN2P3, F-69622 Villeurbanne, France.
    Gottardo, A.
    KTH Royal Inst Technol, S-10691 Stockholm, Sweden;CERN, CH-1211 Geneva 23, Switzerland.
    Jurado, M.
    Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Valencia, Spain.
    Ljungvall, J.
    Univ Paris Saclay, Ctr Sci Nucl & Sci Mat, CNRS, IN2P3, F-91405 Orsay, France.
    Mengoni, D.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy.
    Napoli, D. R.
    Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, Italy.
    Petrache, C. M.
    Univ Paris Saclay, Ctr Sci Nucl & Sci Mat, CNRS, IN2P3, F-91405 Orsay, France.
    Sohler, D.
    MTA Atomki, H-4001 Debrecen, Hungary.
    Timar, J.
    MTA Atomki, H-4001 Debrecen, Hungary.
    Barrientos, D.
    CERN, CH-1211 Geneva 23, Switzerland.
    Bednarczyk, P.
    Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, Ul Radzikowskiego 152, PL-31342 Krakow, Poland.
    Benzoni, G.
    INFN, Sez Milano, I-20133 Milan, Italy.
    Birkenbach, B.
    Univ Cologne, Inst Kernphys, Zulpicher Str 77, D-50937 Cologne, Germany.
    Boston, A. J.
    Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England.
    Boston, H. C.
    Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England.
    Burrows, I.
    STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England.
    Charles, L.
    CNRS, UNISTRA, IPHC, 23 Rue Loess, F-67200 Strasbourg, France.
    Ciemala, M.
    Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, Ul Radzikowskiego 152, PL-31342 Krakow, Poland.
    Crespi, F. C. L.
    Univ Milan, Dept Phys, I-20133 Milan, Italy;INFN Milano, I-20133 Milan, Italy.
    Cullen, D. M.
    Univ Manchester, Nucl Phys Grp, Schuster Lab, Manchester M13 9PL, Lancs, England.
    Desesquelles, P.
    Univ Paris Saclay, Ctr Sci Nucl & Sci Mat, CNRS, IN2P3, F-91405 Orsay, France;Univ Paris Saclay, CNRS, IN2P3, Bat 104, F-91405 Orsay, France.
    Domingo-Pardo, C.
    Univ Valencia, CSIC, Inst Fis Corpuscular, E-46071 Valencia, Spain.
    Eberth, J.
    Univ Cologne, Inst Kernphys, Zulpicher Str 77, D-50937 Cologne, Germany.
    Erduran, N.
    Istanbul Sabahattin Zaim Univ, Fac Engn & Nat Sci, TR-34303 Istanbul, Turkey.
    Erturk, S.
    Nigde Univ, Dept Phys, TR-51240 Nigde, Turkey.
    Gonzalez, V.
    Univ Valencia, Dept Ingn Elect, E-46100 Valencia, Spain.
    Goupil, J.
    CEA DSM CNRS IN2P3, GANIL, Bd Henri Becquerel,BP 55027, F-14076 Caen 5, France.
    Hess, H.
    Univ Cologne, Inst Kernphys, Zulpicher Str 77, D-50937 Cologne, Germany.
    Huyuk, T.
    Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Valencia, Spain.
    Jungclaus, A.
    CSIC, Inst Estruct Mat, E-28006 Madrid, Spain.
    Korten, W.
    Univ Paris Saclay, CEA, Irfu, F-91191 Gif Sur Yvette, France.
    Lemasson, A.
    CEA DSM CNRS IN2P3, GANIL, Bd Henri Becquerel,BP 55027, F-14076 Caen 5, France.
    Leoni, S.
    Univ Milan, Dept Phys, I-20133 Milan, Italy;INFN Milano, I-20133 Milan, Italy.
    Maj, A.
    Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, Ul Radzikowskiego 152, PL-31342 Krakow, Poland.
    Menegazzo, R.
    INFN Padova, I-35131 Padua, Italy.
    Million, B.
    INFN Milano, I-20133 Milan, Italy.
    Perez-Vidal, R. M.
    Univ Valencia, CSIC, Inst Fis Corpuscular, E-46071 Valencia, Spain.
    Podolyak, Zs.
    Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England.
    Pullia, A.
    Univ Milan, Dept Phys, I-20133 Milan, Italy;INFN Milano, I-20133 Milan, Italy.
    Recchia, F.
    INFN Padova, I-35131 Padua, Italy;Univ Padua, Dipartimento Fis & Astron, I-35131 Padua, Italy.
    Reiter, P.
    Univ Cologne, Inst Kernphys, Zulpicher Str 77, D-50937 Cologne, Germany.
    Saillant, F.
    CEA DSM CNRS IN2P3, GANIL, Bd Henri Becquerel,BP 55027, F-14076 Caen 5, France.
    Salsac, M. D.
    Univ Paris Saclay, CEA, Irfu, F-91191 Gif Sur Yvette, France.
    Sanchis, E.
    Univ Valencia, Dept Ingn Elect, E-46100 Valencia, Spain.
    Simpson, J.
    STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England.
    Stezowski, O.
    Univ Lyon 1, CNRS, IN2P3, IPN Lyon, F-69622 Villeurbanne, France.
    Theisen, Ch.
    Univ Paris Saclay, CEA, Irfu, F-91191 Gif Sur Yvette, France.
    Zielinska, M.
    Univ Paris Saclay, CEA, Irfu, F-91191 Gif Sur Yvette, France.
    Isospin Properties of Nuclear Pair Correlations from the Level Structure of the Self-Conjugate Nucleus Ru-882020In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 124, no 6, article id 062501Article in journal (Refereed)
    Abstract [en]

    The low-lying energy spectrum of the extremely neutron-deficient self-conjugate (N = Z) nuclide Ru-88(44)44 has been measured using the combination of the Advanced Gamma Tracking Array (AGATA) spectrometer, the NEDA and Neutron Wall neutron detector arrays, and the DIAMANT charged particle detector array. Excited states in Ru-88 were populated via the Fe-54(Ar-36, 2n gamma)Ru-88* fusion-evaporation reaction at the Grand Accelerateur National d'Ions Lourds (GANIL) accelerator complex. The observed gamma-ray cascade is assigned to Ru-88 using clean prompt gamma-gamma-2-neutron coincidences in anticoincidence with the detection of charged particles, confirming and extending the previously assigned sequence of low-lying excited states. It is consistent with a moderately deformed rotating system exhibiting a band crossing at a rotational frequency that is significantly higher than standard theoretical predictions with isovector pairing, as well as observations in neighboring N > Z nuclides. The direct observation of such a "delayed" rotational alignment in a deformed N = Z nucleus is in agreement with theoretical predictions related to the presence of strong isoscalar neutron-proton pair correlations.

  • Escala-Garcia, Maria
    et al.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands.
    Abraham, Jean
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Cambridge Expt Canc Med Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England.
    Andrulis, Irene L.
    Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
    Anton-Culver, Hoda
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA.
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Ashworth, Alan
    Univ Calif San Francisco, UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA.
    Auer, Paul L.
    Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA;Univ Wisconsin Milwaukee, Zilber Sch Publ Hlth, Milwaukee, WI USA.
    Auvinen, Paivi
    Kuopio Univ Hosp, Canc Ctr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med, Oncol, Kuopio, Finland;Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.
    Beckmann, Matthias W.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany.
    Beesley, Jonathan
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.
    Behrens, Sabine
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Benitez, Javier
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain;Biomed Network Rare Dis CIBERER, Madrid, Spain.
    Bermisheva, Marina
    Ufa Sci Ctr Russian Acad Sci, Inst Biochem & Genet, Ufa, Russia.
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, Orebro, Sweden.
    Blot, William
    Vanderbilt Univ Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr, Dept Med,Div Epidemiol, Nashville, TN USA;Int Epidemiol Inst, Rockville, MD USA.
    Bogdanova, Natalia V.
    Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany;Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany;NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS.
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
    Bolla, Manjeet K.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Borresen-Dale, Anne-Lise
    Oslo Univ Hosp Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
    Brauch, Hiltrud
    Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany;Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany;German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Heidelberg, Germany.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.
    Brucker, Sara Y.
    Univ Tubingen, Dept Gynecol & Obstet, Tubingen, Germany.
    Burwinkel, Barbara
    German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.
    Caldas, Carlos
    Univ Cambridge, Li Ka Shing Ctr, Canc Res UK Cambridge Inst, Dept Oncol, Cambridge, England;CRUK Cambridge Canc Ctr, Breast Canc Programme, Cambridge, England;Cambridge Univ Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, Cambridge, England.
    Canzian, Federico
    German Canc Res Ctr, Gen Epidemiol Grp, Heidelberg, Germany.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany.
    Chanock, Stephen J.
    Natl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA.
    Chin, Suet-Feung
    Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.
    Clarke, Christine L.
    Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
    Cox, Angela
    Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Sheffield, S Yorkshire, England.
    Cross, Simon S.
    Univ Sheffield, Dept Neurosci, Acad Unit Pathol, Sheffield, S Yorkshire, England.
    Czene, Kamila
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, Philadelphia, PA USA.
    Dennis, Joe
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Devilee, Peter
    Leiden Univ Med Ctr, Dept Pathol, Leiden, Netherlands;Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands.
    Dunn, Janet A.
    Univ Warwick, Warwick Clin Trials Unit, Coventry, W Midlands, England.
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England.
    Earl, Helena M.
    Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England;Univ Cambridge, Dept Oncol, Cambridge, England.
    Eccles, Diana M.
    Univ Southampton, Fac Med, Canc Sci Acad Unit, Southampton, Hants, England.
    Eliassen, A. Heather
    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Ellberg, Carolina
    Lund Univ, Dept Canc Epidemiol Clin Sci, Lund, Sweden.
    Evans, D. Gareth
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Med, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, St Marys Hosp,Genom Med, Manchester, Lancs, England;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England.
    Fasching, Peter A.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA USA.
    Figueroa, Jonine
    Natl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA;Univ Edinburgh Med Sch, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland.
    Flyger, Henrik
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark.
    Gago-Dominguez, Manuela
    Complejo Hospitalario Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago Compostela IDIS, Galician Fdn Genom Med,Genom Med Grp, Santiago De Compostela, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA.
    Gapstur, Susan M.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA USA.
    Garcia-Closas, Montserrat
    Natl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA;Inst Canc Res, Div Genet & Epidemiol, London, England.
    Garcia-Saenz, Jose A.
    Hosp Clino San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.
    Gaudet, Mia M.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA USA.
    George, Angela
    Inst Canc Res, Div Genet & Epidemiol, London, England.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
    Goldgar, David E.
    Univ Utah Sch Med Salt, Huntsman Canc Inst, Dept Dermatol, Salt Lake City, UT USA.
    Gonzalez-Neira, Anna
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain.
    Grip, Mervi
    Univ Oulu, Oulu Univ Hosp, Dept Surg, Oulu, Finland.
    Guenel, Pascal
    Univ Paris Sud, INSERM, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP,Canc & Envi, Villejuif, France.
    Guo, Qi
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.
    Hakansson, Niclas
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
    Harrington, Patricia A.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
    Hiller, Louise
    Univ Warwick, Warwick Clin Trials Unit, Coventry, W Midlands, England.
    Hooning, Maartje J.
    Erasmus MC Canc Inst, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands.
    Hopper, John L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
    Howell, Anthony
    Univ Manchester, Div Canc Sci, Manchester, Lancs, England.
    Huang, Chiun-Sheng
    Natl Taiwan Univ Hosp, Dept Surg, Taipei, Taiwan;Natl Taiwan Univ Coll Med, Taipei, Taiwan.
    Huang, Guanmengqian
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
    Hunter, David J.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland.
    John, Esther M.
    Stanford Univ Sch Med, Stanford Canc Inst, Dept Med, Div Oncol, Stanford, CA USA.
    Kaaks, Rudolf
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Kapoor, Pooja Middha
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Heidelberg Univ, Fac Med, Heidelberg, Germany.
    Keeman, Renske
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands.
    Kitahara, Cari M.
    Natl Canc Inst, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD USA.
    Koppert, Linetta B.
    Erasmus MC Canc Inst, Family Canc Clin, Dept Surg Oncol, Rotterdam, Netherlands.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
    Kristensen, Vessela N.
    Oslo Univ Hosp Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
    Lambrechts, Diether
    VIB Ctr Canc Biol, VIB, Leuven, Belgium;Univ Leuven, Lab Translat Genet, Dept Human Genet, Leuven, Belgium.
    Le Marchand, Loic
    Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI USA.
    Lejbkowicz, Flavio
    Clalit Natl Canc Control Ctr, Technion Fac Med, Haifa, Israel;Carmel Hosp, Haifa, Israel.
    Lindblom, Annika
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.
    Mannermaa, Arto
    Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Kuopio, Finland.
    Manoochehri, Mehdi
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
    Manoukian, Siranoush
    Fdn IRCCS Ist Nazl Tumori Milano INT, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy.
    Margolin, Sara
    Ssdersjukhuset, Dept Oncol, Stockholm, Sweden;Karolinska Inst, Ssdersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
    Martinez, Maria Elena
    Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA USA.
    Maurer, Tabea
    Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg UCCH, Canc Epidemiol Grp, Hamburg, Germany.
    Mavroudis, Dimitrios
    Univ Hosp Herakl, Dept Med Oncol, Iraklion, Greece.
    Meindl, Alfons
    Ludwig Maximilian Univ Munich, Dept Gynecol & Obstet, Munich, Germany.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
    Mulligan, Anna Marie
    Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada;Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA.
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland.
    Newman, William G.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Med, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, St Marys Hosp,Genom Med, Manchester, Lancs, England.
    Olshan, Andrew F.
    Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC USA.
    Olson, Janet E.
    Olsson, Hakan
    Lund Univ, Dept Canc Epidemiol Clin Sci, Lund, Sweden.
    Orr, Nick
    Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland.
    Peterlongo, Paolo
    Inst Mol Oncol, IFOM FIRC Italian Fdn Canc Research, Genome Diagnost Program, Milan, Italy.
    Petridis, Christos
    Guys Hosp, Kings Coll London, Res Oncol, London, England.
    Prentice, Ross L.
    Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA.
    Presneau, Nadege
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England.
    Punie, Kevin
    Univ Hosp Leuven, Leuven Canc Inst, Leuven Multidisciplinary Breast Ctr, Dept Oncol, Leuven, Belgium.
    Ramachandran, Dhanya
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.
    Rennert, Gad
    Clalit Natl Canc Control Ctr, Technion Fac Med, Haifa, Israel;Carmel Hosp, Haifa, Israel.
    Romero, Atocha
    Hosp Univ Puerta Hierro, Med Oncol Dept, Madrid, Spain.
    Sachchithananthan, Mythily
    Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.
    Saloustros, Emmanouil
    Univ Hosp Larissa, Dept Oncol, Larisa, Greece.
    Sawyer, Elinor J.
    Guys Hosp, Kings Coll London, Res Oncol, London, England.
    Schmutzler, Rita K.
    Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany;Univ Cologne, Ctr Mol Med Cologne CMMC, Cologne, Germany.
    Schwentner, Lukas
    Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany.
    Scott, Christopher
    Simard, Jacques
    Univ Laval, Ctr Hosp Univ Quebec, Res Ctr, Gen Ctr, Quebec City, PQ, Canada.
    Sohn, Christof
    Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia.
    Swerdlow, Anthony J.
    Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England.
    Tamimi, Rulla M.
    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
    Tapper, William J.
    Univ Southampton, Fac Med, Southampton, Hants, England.
    Teixeira, Manuel R.
    Portuguese Oncol Inst, Dept Genet, Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal.
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
    Thorne, Heather
    Peter MacCallum Canc Ctr, Melbourne, Vic, Australia;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.
    Tollenaar, Rob A. E. M.
    Leiden Univ Med Ctr, Dept Surg, Leiden, Netherlands.
    Tomlinson, Ian
    Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England;Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
    Troester, Melissa A.
    Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC USA.
    Truong, Therese
    Univ Paris Sud, INSERM, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP,Canc & Envi, Villejuif, France.
    Turnbull, Clare
    Inst Canc Res, Div Genet & Epidemiol, London, England.
    Vachon, Celine M.
    van der Kolk, Lizet E.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands.
    Wang, Qin
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Winqvist, Robert
    Univ Oulu, Lab Canc Genet & Tumor Biol, Canc & Translat Med Res Unit, Bioctr Oulu, Oulu, Finland;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu, Finland.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Yang, Xiaohong R.
    Natl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA.
    Ziogas, Argyrios
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Hall, Per
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Ssdersjukhuset, Dept Oncol, Stockholm, Sweden.
    Wessels, Lodewyk F. A.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands;Delft Univ Technol, Fac EEMCS, Delft, Netherlands.
    Chenevix-Trench, Georgia
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.
    Bader, Gary D.
    Univ Toronto, Dept Mol Genet, Toronto, ON, Canada;Univ Toronto, Donnelly Ctr, Toronto, ON, Canada.
    Doerk, Thilo
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.
    Easton, Douglas F.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Canisius, Sander
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands.
    Schmidt, Marjanka K.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.
    A network analysis to identify mediators of germline-driven differences in breast cancer prognosis2020In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 11, no 1, article id 312Article in journal (Refereed)
    Abstract [en]

    Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies similar to 7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.

  • Carlsson, Henrik
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Abujrais, Sandy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Herman, Stephanie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Emami Khoonsari, Payam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Åkerfeldt, Torbjörn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Svenningsson, Anders
    Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
    Burman, Joachim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Landtblom: Neurology.
    Kultima, Kim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry2020In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 16, no 2, article id 26Article in journal (Refereed)
    Abstract [en]

    Introduction: Standardized commercial kits enable targeted metabolomics analysis and may thus provide an attractive complement to the more explorative approaches. The kits are typically developed for triple quadrupole mass spectrometers using serum and plasma.

    Objectives: Here we measure the concentrations of preselected metabolites in cerebrospinal fluid (CSF) using a kit developed for high-resolution mass spectrometry (HRMS). Secondarily, the study aimed to investigate metabolite alterations in patients with secondary progressive multiple sclerosis (SPMS) compared to controls.

    Methods: We performed targeted metabolomics in human CSF on twelve SPMS patients and twelve age and sex-matched healthy controls using the Absolute IDQ-p400 kit (Biocrates Life Sciences AG) developed for HRMS. The extracts were analysed using two methods; liquid chromatography-mass spectrometry (LC-HRMS) and flow injection analysis-MS (FIA-HRMS).

    Results: Out of 408 targeted metabolites, 196 (48%) were detected above limit of detection and 35 were absolutely quantified. Metabolites analyzed using LC-HRMS had a median coefficient of variation (CV) of 3% and 2.5% between reinjections the same day and after prolonged storage, respectively. The corresponding results for the FIA-HRMS were a median CV of 27% and 21%, respectively. We found significantly (p < 0.05) elevated levels of glycine, asymmetric dimethylarginine (ADMA), glycerophospholipid PC-O (34:0) and sum of hexoses in SPMS patients compared to controls.

    Conclusion: The Absolute IDQ-p400 kit could successfully be used for quantifying targeted metabolites in the CSF. Metabolites quantified using LC-HRMS showed superior reproducibility compared to FIA-HRMS.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of J/psi production in association with a W-+/- boson with pp data at 8 TeV2020In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 1, article id 95Article in journal (Refereed)
    Abstract [en]

    A measurement of the production of a prompt J/psi meson in association with a W-+/- boson with W-+/- -> mu nu and J/psi -> mu(+)mu(-) is presented for J/psi transverse momenta in the range 8.5-150 GeV and rapidity |y(J/psi)| < 2.1 using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton-proton centre-of-mass energy of s = 8 TeV and correspond to an integrated luminosity of 20.3 fb(-1). The ratio of the prompt J/psi plus W-+/- cross-section to the inclusive W-+/- cross-section is presented as a differential measurement as a function of J/psi transverse momenta and compared with theoretical predictions using different double-parton-scattering cross-sections.

  • Marboe, Christian
    et al.
    Stockholm Univ, Nordita, Roslagstullsbacken 23, SE-10691 Stockholm, Sweden;KTH Royal Inst Technol, Roslagstullsbacken 23, SE-10691 Stockholm, Sweden.
    Widén, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Stockholm Univ, Nordita, Roslagstullsbacken 23, SE-10691 Stockholm, Sweden;KTH Royal Inst Technol, Roslagstullsbacken 23, SE-10691 Stockholm, Sweden.
    The fate of the Konishi multiplet in the β-deformed Quantum Spectral Curve2020In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 1, article id 26Article in journal (Refereed)
    Abstract [en]

    We investigate the solution space of the β-deformed Quantum Spectral Curve by studying a sample of solutions corresponding to single-trace operators that in the undeformed theory belong to the Konishi multiplet. We discuss how to set the precise boundary conditions for the leading Q-system for a given state, how to solve it, and how to build perturbative corrections to the Pμ-system. We confirm and add several loop orders to known results in the literature.

  • Ebadi, Mahsa
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Eriksson, Therese
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Mandal, Prithwiraj
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Costa, Luciano T.
    Univ Fed Fluminense, Inst Quim, Dept Fis Quim, BR-24020150 Niteroi, RJ, Brazil.
    Araujo, Carlos Moyses
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Mindemark, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Brandell, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Restricted Ion Transport by Plasticizing Side Chains in Polycarbonate-Based Solid Electrolytes2020In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 53, no 3, p. 764-774Article in journal (Refereed)
    Abstract [en]

    Increasing the ionic conductivity has for decades been an overriding goal in the development of solid polymer electrolytes. According to fundamental theories on ion transport mechanisms in polymers, the ionic conductivity is strongly correlated to free volume and segmental mobility of the polymer for the conventional transport processes. Therefore, incorporating plasticizing side chains onto the main chain of the polymer host often appears as a clear-cut strategy to improve the ionic conductivity of the system through lowering of the glass transition temperature (T-g) This intended correlation between Tg and ionic conductivity is, however, not consistently observed in practice. The aim of this study is therefore to elucidate this interplay between segmental mobility and polymer structure in polymer electrolyte systems comprising plasticizing side chains. To this end, we utilize the synthetic versatility of the ion-conductive poly(trimethylene carbonate) (PTMC) platform. Two types of host polymers with side chains added to a PTMC backbone are employed, and the resulting electrolytes are investigated together with the side chain-free analogue both by experiment and with molecular dynamics (MD) simulations. The results show that while added side chains do indeed lead to a lower Tg, the total ionic conductivity is highest in the host matrix without side chains. It was seen in the MD simulations that while side chains promote ionic mobility associated with the polymer chain, the more efficient interchain hopping transport mechanism occurs with a higher probability in the system without side chains. This is connected to a significantly higher solvation site diversity for the Li+ ions in the side-chain-free system, providing better conduction paths. These results strongly indicate that the side chains in fact restrict the mobility of the Li+ ions in the polymer hosts.

  • Käll, Anton
    et al.
    Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden.
    Backlund, Ulrika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Shafran, Roz
    UCL Great Ormond St Inst Child Hlth, London, England.
    Andersson, Gerhard
    Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Lonesome no more?: A two-year follow-up of internet-administered cognitive behavioral therapy for loneliness2020In: Internet Interventions, ISSN 2214-7829, Vol. 19, article id 100301Article in journal (Refereed)
    Abstract [en]

    The current study sought to investigate the long-term effects of an internet-administered programme based on CBT principles for which the initial efficacy has been reported in Kall, Jagholm, et al. (In press). Seventy-three participants who were recruited on the basis of experiencing frequent and prolonged loneliness were contacted to complete questionnaires measuring loneliness, quality of life, and symptoms of psychopathology two years after the conclusion of the initial treatment period. Additional items regarding use of the treatment techniques and strategies contained in the programme during the follow-up period was included. In total, 44 participants provided data for the loneliness measure at follow-up. The outcome data were analyzed with a piecewise mixed effects model to provide estimates of change for the continuous measures. Linear multiple regression analysis was used to investigate the relationship between use of treatment techniques and reliable change on the primary outcome measure. The results showed decreases in loneliness during the follow-up period for the sample as a whole. Additionally, an increase in quality of life and a decrease in social anxiety were noted, but no significant changes of depressive symptoms or generalized anxiety. Effect sizes for the observed changes from baseline to follow-up were in the moderate to large range for all measures. Reported use of the treatment techniques was not significantly related to reliable change in loneliness after the two-year period. In conclusion, the results of the study support the utility of internet-based CBT targeting loneliness and indicate that the benefits from the intervention can be enduring.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of the top-quark mass in tt 1-jet events collected with the ATLAS detector in pp collisions at=8 TeV2019In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 11, article id 150Article in journal (Refereed)
    Abstract [en]

    A determination of the top-quark mass is presented using 20.2 fb-1 of 8 TeV proton-proton collision data produced by the Large Hadron Collider and collected by the ATLAS experiment. The normalised differential cross section of top-quark pair production in association with an energetic jet is measured in the lepton+jets final state and unfolded to parton and particle levels. The unfolded distribution at parton level can be described using next-to-leading-order QCD predictions in terms of either the top-quark pole mass or the running mass as defined in the (modified) minimal subtraction scheme. A comparison between the experimental distribution and the theoretical prediction allows the top-quark mass to be extracted in the two schemes. The value obtained for the pole-mass scheme is: rnirle 171.1 0.4 (stat) 0.9 (syst) 173 (theo) GeV. The extracted value in the running-mass scheme is: rnt(rnt) = 162.9 0.5 (stat) 1.0 (syst) 1:12 (theo) GeV. The results for the top -quark mass using the two schemes are consistent, when translated from one scheme to the other.

  • Yamamoto, Kohei
    et al.
    Univ Tokyo, Inst Solid State Phys, Chiba 2778581, Japan;Univ Tokyo, Dept Phys, Tokyo 1130033, Japan;Inst Mol Sci, Okazaki, Aichi 4448585, Japan.
    Kubota, Yuya
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan;RIKEN, SPring 8 Ctr, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
    Suzuki, Motohiro
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan.
    Hirata, Yasuyuki
    Univ Tokyo, Inst Solid State Phys, Chiba 2778581, Japan;Univ Tokyo, Dept Phys, Tokyo 1130033, Japan;Natl Def Acad Japan, Yokosuka, Kanagawa 2398686, Japan.
    Carva, Karel
    Charles Univ Prague, Fac Math & Phys, Dept Condensed Matter Phys, Ke Karlovu 5, Prague 12116, Czech Republic.
    Berritta, Marco
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Takubo, Kou
    Univ Tokyo, Inst Solid State Phys, Chiba 2778581, Japan;Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan.
    Uemura, Yohei
    Inst Mol Sci, Okazaki, Aichi 4448585, Japan;Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Fukaya, Ryo
    High Energy Accelerator Res Org, Inst Mat Struct Sci, Tsukuba, Ibaraki 3050801, Japan.
    Tanaka, Kenta
    Univ Hyogo, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan.
    Nishimura, Wataru
    Univ Hyogo, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan.
    Ohkochi, Takuo
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan.
    Katayama, Tetsuo
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan;RIKEN, SPring 8 Ctr, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
    Togashi, Tadashi
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan;RIKEN, SPring 8 Ctr, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
    Tamasaku, Kenji
    RIKEN, SPring 8 Ctr, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
    Yabashi, Makina
    Japan Synchrotron Radiat Res Inst, 1-1-1 Kouto, Sayo, Hyogo 6795198, Japan;RIKEN, SPring 8 Ctr, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
    Tanaka, Yoshihito
    Univ Hyogo, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan.
    Seki, Takeshi
    Tohoku Univ, Inst Mat Res, Sendai, Miyagi 9808577, Japan;Tohoku Univ, Ctr Spintron Res Network, Sendai, Miyagi 9808577, Japan.
    Takanashi, Koki
    Tohoku Univ, Inst Mat Res, Sendai, Miyagi 9808577, Japan;Tohoku Univ, Ctr Spintron Res Network, Sendai, Miyagi 9808577, Japan.
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Wadati, Hiroki
    Univ Tokyo, Inst Solid State Phys, Chiba 2778581, Japan;Univ Tokyo, Dept Phys, Tokyo 1130033, Japan;Univ Hyogo, Grad Sch Mat Sci, Kamigori, Hyogo 6781297, Japan.
    Ultrafast demagnetization of Pt magnetic moment in L1(0)-FePt probed by magnetic circular dichroism at a hard x-ray free electron laser2019In: New Journal of Physics, ISSN 1367-2630, E-ISSN 1367-2630, Vol. 21, no 12, article id 123010Article in journal (Refereed)
    Abstract [en]

    Unraveling the origin of ultrafast demagnetization in multisublattice ferromagnetic materials requires femtosecond x-ray techniques to trace the magnetic moment dynamics on individual elements, but this could not yet be achieved in the hard x-ray regime. We demonstrate here the first ultrafast demagnetization dynamics in the ferromagnetic heavy 5d-transition metal Pt using circularly-polarized hard x-rays at an x-ray free electron laser (XFEL). The decay time of laser-induced demagnetization of L1(0)-FePt is determined to be tau(Pt) = 0.61 +/- 0.04 ps using time-resolved x-ray magnetic circular dichroism at the Pt L-3 edge, whereas magneto-optical Kerr measurements indicate the decay time for the total magnetization as tau(total) < 0.1 ps. A transient magnetic state with a photomodulated ratio of the 3d and 5d magnetic moments is demonstrated for pump-probe delays larger than 1 ps. We explain this distinct photo-modulated transient magnetic state by the induced-moment behavior of the Pt atom and the x-ray probing depth. Our findings pave the way for the future use of XFELs to disentangle atomic spin dynamics contributions.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of ZZ production in the ll nu nu final state with the ATLAS detector in pp collisions at root s=13 TeV2019In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 10, article id 127Article in journal (Refereed)
    Abstract [en]

    This paper presents a measurement of ZZ production with the ATLAS detector at the Large Hadron Collider. The measurement is carried out in the final state with two charged leptons and two neutrinos, using data collected during 2015 and 2016 in pp collisions at root s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb(-1). The integrated cross-sections in the total and fiducial phase spaces are measured with an uncertainty of 7% and compared with Standard Model predictions, and differential measurements in the fiducial phase space are reported. No significant deviations from the Standard Model predictions are observed, and stringent constraints are placed on anomalous couplings corresponding to neutral triple gauge-boson interactions.

  • Ablikim, M.
    et al.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Biernat, Jacek
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Ikegami Andersson, Walter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Search for baryon and lepton number violating decays D+ -> (Lambda)over-bar((Sigma)over-bar(0))e(+) and D+ -> Lambda(Sigma(0))e(+)2020In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 101, no 3, article id 031102Article in journal (Refereed)
    Abstract [en]

    Using a 2.93 fb(-1) data sample of electron-positron collisions taken with the BESIII detector at a center-of-mass energy of 3.773 GeV, which corresponds to (8296 +/- 31 +/- 64) x 10(3) D+ D- pairs, we search for the baryon and lepton number violating decays D+ -> (Lambda) over bar((Sigma) over bar (0))e(+) and D+ -> Lambda(Sigma(0))e(+). No obvious signals are found with the current statistics and upper limits on the branching fractions of these four decays are set at the level of 10(-6) at 90% confidence level.

  • Aad, G.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of the azimuthal anisotropy of charged-particle production in Xe plus Xe collisions at root S-NN=5.44 TeV with the ATLAS detector2020In: Physical Review C: Covering Nuclear Physics, ISSN 2469-9985, E-ISSN 2469-9993, Vol. 101, no 2, article id 024906Article in journal (Refereed)
    Abstract [en]

    This paper describes the measurements of flow harmonics v(2)-v(6) in 3 mu b(-1) of Xe Xe collisions at root S-NN = 5.44 TeV performed using the ATLAS detector at the Large Hadron Collider (LHC). Measurements of the centrality, multiplicity, and p(T) dependence of the v(n) obtained using two-particle correlations and the scalar product technique are presented. The measurements are also performed using a template-fit procedure, which was developed to remove nonflow correlations in small collision systems. This nonflow removal is shown to have a significant influence on the measured v(n) at high p(T), especially in peripheral events. Comparisons of the measured v(n) with measurements in Pb + Pb collisions and p + Pb collisions at root S-NN = 5.02 TeV are also presented. The v(n) values in Xe + Xe collisions are observed to be larger than those in Pb + Pb collisions for n = 2, 3, and 4 in the most central events. However, with decreasing centrality or increasing harmonic order n, the v(n) values in Xe + Xe collisions become smaller than those in Pb + Pb collisions. The v(n) in Xe + Xe and Pb + Pb collisions are also compared as a function of the mean number of participating nucleons, < N-part >, and the measured charged-particle multiplicity in the detector. The v(3) values in Xe + Xe and Pb + Pb collisions are observed to be similar at the same < N-part > or multiplicity, but the other harmonics are significantly different. The ratios of the measured v(n) in Xe + Xe and Pb + Pb collisions, as a function of centrality, are also compared to theoretical calculations.

  • Irisarri, Iker
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. CSIC, Museo Nacl Ciencias Nat, Dept Biodivers & Evolutionary Biol, C Jose Gutierrez Abascal 2, E-28006 Madrid, Spain.
    Uribe, Juan E.
    CSIC, Museo Nacl Ciencias Nat, Dept Biodivers & Evolutionary Biol, C Jose Gutierrez Abascal 2, E-28006 Madrid, Spain;Natl Museum Nat Hist, Smithsonian Inst, Dept Invertebrate Zool, 10th St & Constitut Ave NW, Washington, DC 20560 USA.
    Eernisse, Douglas J.
    Calif State Univ Fullerton, Dept Biol Sci, 800 N State Coll Blvd, Fullerton, CA 92831 USA.
    Zardoya, Rafael
    CSIC, Museo Nacl Ciencias Nat, Dept Biodivers & Evolutionary Biol, C Jose Gutierrez Abascal 2, E-28006 Madrid, Spain.
    A mitogenomic phylogeny of chitons (Mollusca: Polyplacophora)2020In: BMC Evolutionary Biology, ISSN 1471-2148, E-ISSN 1471-2148, Vol. 20, no 1, article id 22Article in journal (Refereed)
    Abstract [en]

    Background

    Polyplacophora, or chitons, have long fascinated malacologists for their distinct and rather conserved morphology and lifestyle compared to other mollusk classes. However, key aspects of their phylogeny and evolution remain unclear due to the few morphological, molecular, or combined phylogenetic analyses, particularly those addressing the relationships among the major chiton lineages.

    Results

    Here, we present a mitogenomic phylogeny of chitons based on 13 newly sequenced mitochondrial genomes along with eight available ones and RNAseq-derived mitochondrial sequences from four additional species. Reconstructed phylogenies largely agreed with the latest advances in chiton systematics and integrative taxonomy but we identified some conflicts that call for taxonomic revisions. Despite an overall conserved gene order in chiton mitogenomes, we described three new rearrangements that might have taxonomic utility and reconstructed the most likely scenario of gene order change in this group. Our phylogeny was time-calibrated using various fossils and relaxed molecular clocks, and the robustness of these analyses was assessed with several sensitivity analyses. The inferred ages largely agreed with previous molecular clock estimates and the fossil record, but we also noted that the ambiguities inherent to the chiton fossil record might confound molecular clock analyses.

    Conclusions

    In light of the reconstructed time-calibrated framework, we discuss the evolution of key morphological features and call for a continued effort towards clarifying the phylogeny and evolution of chitons.

  • Katsogiannos, Petros
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Kamble, Prasad G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Wiklund, Urban
    Umea Univ, Radiat Sciences, BioMed Engn & Informat, Umea, Sweden.
    Sundbom, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    Espes, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Hammar, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Karlsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Pereira, Maria J
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Eriksson, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Rapid changes in neuroendocrine regulation may contribute to reversal of type 2 diabetes after gastric bypass surgery2020In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 67, no 2, p. 344-353Article in journal (Refereed)
    Abstract [en]

    Objective: To explore the role of hormones and the autonomic nervous system in the rapid remission of diabetes after Roux-en-Y Gastric Bypass (RYGB).

    Research design and methods: Nineteen obese patients with type 2 diabetes, 7 M/12 F, were randomized (2:1) to RYGB or standard-of-care medical treatment (control). At baseline and 4 and 24 weeks post surgery, fasting blood sampling, OGTT, intravenous arginine challenge, and heart-rate variability (HRV) assessments were performed.

    Results: At both 4 and 24 weeks post-RYGB the following effects were found: arginine-stimulated insulin secretion was reduced. GLP-1, GIP, and glucagon rise during OGTT was enhanced. IGF-1 and GH levels increased. In addition, total HRV and spectral components P-LF (power of low frequency) and P-HF (power of high frequency) increased. At 4 weeks, morning cortisol was lower than baseline and 24 weeks. At 24 weeks, NEFA levels during OGTT, and the P-LF/P-HF ratio decreased. None of these changes were seen in the control group.

    Conclusions: There were rapid changes within 4 weeks after RYGB: signs of enhanced parasympathetic nerve activity, reduced morning cortisol, and enhanced incretin and glucagon responses to glucose. The findings suggest that neurohormonal mechanisms can contribute to the rapid improvement of insulin resistance and glycemia following RYGB in type 2 diabetes.

  • Owesson, Sofie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Förändring i fysisk aktivitet hos barn som deltagit i en intervention2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Children's health can be affected by insufficient physical activity together with an over-exposure of screen-time. This could contribute to social differences in health between individuals.

    Aim: The aim of the study was to examine the effects of the intervention ”En frisk generation” on physical activity habits, screen-time and physical fitness in second grade children.

    Methods: The Study design was a controlled study with an intervention and a control group. In total, the sample consisted of 67 children, where 36 belonged to the intervention and 31 to control-group. Intervention was based on different physical activities for families to try out in a nine months period, twice a week. The effect of the intervention “En frisk generation” valuate with a measuring-instrument survey with selected standard questions. Following implemented analysismethods were T-test, Mann-Whitney U-test, Chi-square test and ANCOVA. The variables gender, parental education-level and the baseline value were adjusted in the ANCOVA analysis.

    Main result: The intervention “En frisk generation” had no significant effects on either physical activity habits, screen-time or physical fitness in second grade children, because no significant differences could be found between the intervention and control group. When it comes to screentime, changes were seen within the group through significant differences. For physical fitness there was no change within the group during follow-up measurement, with regard to differences in meanvalue.

    Conclusion: The intervention ”En frisk generation” did not show any effect on physical activity habits, screen-time or physical fitness. No significant difference was found between the groups in second grade children. The content is that more studies needs to be done on a larger proportion of children in families, whose parents have a lower socioeconomic status. This needs to be done to see if family interventions have any effect on these variables.

  • Balgoma, David
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
    Zelleroth, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Grönbladh, Alfhild
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Hallberg, Mathias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Pettersson, Curt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
    Hedeland, Mikael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
    Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver2020In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 16, no 1, article id 12Article in journal (Refereed)
    Abstract [en]

    Introduction: The abuse of anabolic androgenic steroids (AASs) is a source of public concern because of their adverse effects. Supratherapeutic doses of AASs are known to be hepatotoxic and regulate the lipoproteins in plasma by modifying the metabolism of lipids in the liver, which is associated with metabolic diseases. However, the effect of AASs on the profile of lipids in plasma is unknown.

    Objectives: To describe the changes in the plasma lipidome exerted by AASs and to discuss these changes in the light of previous research about AASs and de novo lipogenesis in the liver.

    Methods: We treated male Wistar rats with supratherapeutic doses of nandrolone decanoate and testosterone undecanoate. Subsequently, we isolated the blood plasma and performed lipidomics analysis by liquid chromatography-high resolution mass spectrometry.

    Results: Lipid profiling revealed a decrease of sphingolipids and glycerolipids with palmitic, palmitoleic, stearic, and oleic acids. In addition, lipid profiling revealed an increase in free fatty acids and glycerophospholipids with odd-numbered chain fatty acids and/or arachidonic acid.

    Conclusion: The lipid profile presented herein reports the imprint of AASs on the plasma lipidome, which mirrors the downregulation of de novo lipogenesis in the liver. In a broader perspective, this profile will help to understand the influence of androgens on the lipid metabolism in future studies of diseases with dysregulated lipogenesis (e.g. type 2 diabetes, fatty liver disease, and hepatocellular carcinoma).

  • Iliasov, Askar
    et al.
    Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525AJ Nijmegen, Netherlands;Russian Acad Sci, Space Res Inst, Moscow 117997, Russia.
    Bagrov, Andrey A.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525AJ Nijmegen, Netherlands.
    Katsnelson, Mikhail I.
    Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525AJ Nijmegen, Netherlands.
    Krikun, Alexander
    Leiden Univ, ITP, Inst Lorentz Theoret Phys, Niels Bohrweg 2, NL-2333CA Leiden, Netherlands.
    Anisotropic destruction of the Fermi surface in inhomogeneous holographic lattices2020In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 1, article id 65Article in journal (Refereed)
    Abstract [en]

    We analyze fermionic response of strongly correlated holographic matter in presence of inhomogeneous periodically modulated potential mimicking the crystal lattice. The modulation is sourced by a scalar operator that explicitly breaks the translational symmetry in one direction. We compute the fermion spectral function and show that it either exhibits a well defined Fermi surface with umklapp gaps opening on the Brillouin zone boundary at small lattice wave vector, or, when the wave vector is large, the Fermi surface is anisotropically deformed and the quasiparticles get significantly broadened in the direction of translation symmetry breaking. Making use of the ability of our model to smoothly extrapolate to the homogeneous Q-lattice like setup, we show that this novel effect is not due to the periodic modulation of the potential and Umklapp physics, but rather due to the anisotropic features of the holographic horizon. That means it encodes novel physics of strongly correlated critical systems which may be relevant for phenomenology of exotic states of electron matter.