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  • Hjort, Rebecka
    et al.
    Karolinska Inst, Inst Environm Med, Unit Epidemiol, Box 210, S-17177 Stockholm, Sweden.
    Ahlqvist, Emma
    Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden.
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
    Grill, Valdemar
    Norwegian Univ Sci & Technol, Dept Clin & Mol Med, NTNU, Trondheim, Norway;Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Trondheim, Norway.
    Groop, Leif
    Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden;Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland.
    Martinell, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Rasouli, Bahareh
    Karolinska Inst, Inst Environm Med, Unit Epidemiol, Box 210, S-17177 Stockholm, Sweden.
    Rosengren, Anders
    Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden.
    Tuomi, Tiinamaija
    Univ Helsinki, Helsinki Univ Hosp, Div Endocrinol, Abdominal Ctr,Res Program Diabet & Obes, Helsinki, Finland;Folkhalsan Res Ctr, Helsinki, Finland.
    Asvold, Bjorn Olav
    Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Trondheim, Norway;Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, NTNU, Trondheim, Norway.
    Carlsson, Sofia
    Karolinska Inst, Inst Environm Med, Unit Epidemiol, Box 210, S-17177 Stockholm, Sweden.
    Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study2018In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 6, p. 1333-1343Article in journal (Refereed)
    Abstract [en]

    Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. Results In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; <median) (OR 4.25; 95% CI 2.76, 6.52) but present also in LADA with high GADA (OR 2.14; 95% CI 1.42, 3.24). In the Swedish data, obese vs normal weight LADA patients had lower GADA levels, better beta cell function, and were more likely to have low-risk HLA-genotypes. The combination of overweight and family history of diabetes (FHD) conferred an OR of 4.57 (95% CI 3.27, 6.39) for LADA and 24.51 (95% CI 17.82, 33.71) for type 2 diabetes. Prospective data from HUNT indicated even stronger associations; HR for LADA was 6.07 (95% CI 3.76, 9.78) for obesity and 7.45 (95% CI 4.02, 13.82) for overweight and FHD. Conclusions/interpretation Overweight/obesity is associated with increased risk of LADA, particularly when in combination with FHD. These findings support the hypothesis that, even in the presence of autoimmunity, factors linked to insulin resistance, such as excessive weight, could promote onset of diabetes.

  • Chen, Joe P.
    et al.
    Colgate Univ, Hamilton, NY 13346 USA.
    Teplyaev, Alexander
    Univ Connecticut, Storrs, CT 06269 USA.
    Tsougkas, Konstantinos
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Regularized Laplacian determinants of self-similar fractals2018In: Letters in Mathematical Physics, ISSN 0377-9017, E-ISSN 1573-0530, Vol. 108, no 6, p. 1563-1579Article in journal (Refereed)
    Abstract [en]

    We study the spectral zeta functions of the Laplacian on fractal sets which are locally self-similar fractafolds, in the sense of Strichartz. These functions are known to meromorphically extend to the entire complex plane, and the locations of their poles, sometimes referred to as complex dimensions, are of special interest. We give examples of locally self-similar sets such that their complex dimensions are not on the imaginary axis, which allows us to interpret their Laplacian determinant as the regularized product of their eigenvalues. We then investigate a connection between the logarithm of the determinant of the discrete graph Laplacian and the regularized one.

  • Price, Nicholas
    et al.
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Moyers, Brook T.
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Lopez, Lua
    Penn State Univ, Dept Biol, University Pk, PA 16802 USA.
    Lasky, Jesse R.
    Penn State Univ, Dept Biol, University Pk, PA 16802 USA.
    Monroe, J. Grey
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Mullen, Jack L.
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Oakley, Christopher G.
    Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 USA;Purdue Univ, Ctr Plant Biol, W Lafayette, IN 47907 USA.
    Lin, Junjiang
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Ågren, Jon
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Schrider, Daniel R.
    Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA.
    Kern, Andrew D.
    Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA.
    McKay, John K.
    Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA.
    Combining population genomics and fitness QTLs to identify the genetics of local adaptation in Arabidopsis thaliana2018In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, no 19, p. 5028-5033Article in journal (Refereed)
    Abstract [en]

    Evidence for adaptation to different climates in the model species Arabidopsis thaliana is seen in reciprocal transplant experiments, but the genetic basis of this adaptation remains poorly understood. Field-based quantitative trait locus (QTL) studies provide direct but low-resolution evidence for the genetic basis of local adaptation. Using high-resolution population genomic approaches, we examine local adaptation along previously identified genetic trade-off (GT) and conditionally neutral (CN) QTLs for fitness between locally adapted Italian and Swedish A. thaliana populations [angstrom gren J, et al. (2013) Proc Natl Acad Sci USA 110: 21077-21082]. We find that genomic regions enriched in high F-ST SNPs colocalize with GT QTL peaks. Many of these high F-ST regions also colocalize with regions enriched for SNPs significantly correlated to climate in Eurasia and evidence of recent selective sweeps in Sweden. Examining unfolded site frequency spectra across genes containing high F-ST SNPs suggests GTs may be due to more recent adaptation in Sweden than Italy. Finally, we collapse a list of thousands of genes spanning GT QTLs to 42 genes that likely underlie the observed GTs and explore potential biological processes driving these trade-offs, from protein phosphorylation, to seed dormancy and longevity. Our analyses link population genomic analyses and field-based QTL studies of local adaptation, and emphasize that GTs play an important role in the process of local adaptation.

  • Blomgren, Eric
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Nedre Dalalven Utvecklings AB, Swedish Biol Mosquito Control, Uppsala, Sweden.
    Hesson, Jenny C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Liverpool, Inst Infect & Global Hlth, Dept Epidemiol & Populat Hlth, Liverpool, Merseyside, England.
    Schafer, Martina L.
    Nedre Dalalven Utvecklings AB, Swedish Biol Mosquito Control, Uppsala, Sweden.
    Lundström, Jan O.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Nedre Dalalven Utvecklings AB, Swedish Biol Mosquito Control, Uppsala, Sweden.
    Pest occurrence of Aedes rossicus close to the Arctic Circle in northern Sweden2018In: Journal of Vector Ecology, ISSN 1081-1710, E-ISSN 1948-7134, Vol. 43, no 1, p. 36-43Article in journal (Refereed)
    Abstract [en]

    Major nuisance species are found among the floodwater mosquitoes and snow-pool mosquitoes, with the former being the main reason for mosquito control in most areas. Nuisance species vary with the area, and previous reports from northern areas conclude that the nuisance is most often caused by snow-pool mosquitoes. We investigated the mosquito fauna and abundances of host-seeking females using CDC traps baited with carbon dioxide, in overtornea city near the Arctic Circle in northern Sweden, after earlier complaints about massive mosquito nuisance. The abundance of host-seeking female mosquitoes was high in 2014, with a maximum of similar to 15,400 individuals per CDC trap night, of which 89% was the floodwater mosquito Aedes rossicus. Surprisingly, the main nuisance species was a floodwater mosquito, occurring at the northernmost location it has ever been recorded in Sweden. Our report is probably the first documentation of such large numbers of Aedes rossicus in any locality and probably the first documentation of a severe floodwater mosquito nuisance near the Arctic Circle. Given the historical data on river discharge in the area, the nuisance is recurrent. We conclude that in northern localities, as well as in more southern localities, production of floodwater mosquitoes is a natural component of the floodplain fauna of rivers with a fluctuating water flow regime. Also, the floodwater mosquitoes Aedes sticticus and Aedes vexans were found north of their formerly known distribution in Sweden.

  • Afram, Gabriel
    et al.
    Karolinska Univ Hosp Huddinge, Dept Hematol, Stockholm, Sweden.
    Perez Simon, Jose Antonio
    Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Hematol,Inst Biomed Sevilla IBIS, Seville, Spain.
    Remberger, Mats
    Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat, Stockholm, Sweden.
    Caballero-Velazquez, Teresa
    Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Hematol,Inst Biomed Sevilla IBIS, Seville, Spain.
    Martino, Rodrigo
    Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain.
    Luis Pinana, Jose
    Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain;Hosp Clin Univ, Dept Hematol, Valencia, Spain.
    Ringden, Olle
    Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat, Stockholm, Sweden.
    Esquirol, Albert
    Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain.
    Lopez-Corral, Lucia
    Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain.
    Garcia, Irene
    Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain.
    Lopez-Godino, Oriana
    Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain.
    Sierra, Jordi
    Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain.
    Caballero, Dolores
    Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain.
    Ljungman, Per
    Vazquez, Lourdes
    Hosp Univ Salamanca IBSAL, Dept Hematol, Salamanca, Spain.
    Hägglund, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting2018In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 35, no 6, article id 79Article in journal (Refereed)
    Abstract [en]

    Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p < 0.001], prior acute GVHD [1.30, p = 0.024], and RIC [1.36, p = 0.028] increased overall cGVHD. In addition, RIC [4.85, p < 0.001], prior aGVHD [2.14, p = 0.001] and female donor to male recipient [1.80, p = 0.008] increased the risk of severe cGVHD. ATG had a protective effect for both overall [0.41, p < 0.001] and severe cGVHD [0.20, p < 0.001]. Relapse-free survival (RFS) was impaired in patients with severe cGVHD. RIC, prior aGVHD, and female-to-male donation increase the risk of severe cGVHD. ATG reduces the risk of all grades of cGVHD without hampering RFS. GVHD prophylaxis may be tailored according to the risk profile of patients.

  • Sopher, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Converting scanned images of seismic reflection data into SEG-Y format2018In: EARTH SCIENCE INFORMATICS, ISSN 1865-0473, Vol. 11, no 2, p. 241-255Article in journal (Refereed)
    Abstract [en]

    Archives across the world contain vast amounts of old or "vintage" seismic reflection data, which are largely inaccessible for geo-scientific research, due to the out-dated media on which they are stored. Despite the age of these data, they often have great potential to be of use in modern day research. It is often the case that seismic reflection data within these archives are only available as a processed stacked section, printed on paper or film. In this study, a method for the conversion (vectorization) of scanned images of stacked reflection seismic data to standard SEG-Y format is presented. The method addresses data displayed with a line denoting the waveform, where areas on one side of the baseline are shaded (i.e. wiggle trace, variable fill). The method provides an improvement on other published methods utilized within currently available academic software. Unlike previous studies, the method used to detect trace baselines and to detect and remove timelines on the seismic image is described in detail. Furthermore, a quantitative analysis of the performance of the method is presented, showing that an average trace-to-trace correlation coefficient of between 0.8 and 0.95 can be achieved for typical plotting styles. Finally, a case study where the method is applied to vectorize over 1700 km of land seismic data from the island of Gotland (Sweden) is presented.

  • Dagerbratt, Max
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Lindmark, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Ormos, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Beaconlogin - an Efficient Way to Register Presence on Construction Sites2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    As of January the first, 2016, all companies working in the Swedish construction industry must follow a new law. The law makes it mandatory for anyone carrying out construction activities to have electronic staff registers on their sites. Failing to present a correct registration of all personnel present at the construction site will result in a fine ranging from 15,000 SEK to 25,000 SEK. Our solution for a simple way of registration builds on Bluetooth technology combined with a smartphone application. Together with Bluetooth devices, the registration can be done automatically which eliminates the need for construction workers to actively search for the e-staff register.

  • Appelstål, Michael
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Michalak, Jonatan
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Österberg, Melker
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Easy to Use Graphical User Interface for Robot Programming2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The field of robotics is growing rapidly due to the demand of robotic labor, but it is still relatively complicated for someone unexperienced to program a robot. In this project we have developed a web-based graphical user interface and scripting language for programming robot arms. The goal was to make the user interface so easy to use that people with no previous experience can use it to program the robots. The finished product is a web-based drag and drop application which generates robot control code in FeatherScript, a scripting language built by us for this project. The graphical user interface satisfies all technical requirements and from a survey on user experience we can conclude that the GUI is easy to use.

  • Åhman, Lisa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hansson, Julia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelse av förvirringstillstånd: Under och efter vårdtiden på intensivvårdsavdelning2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund. Patienter som vårdas eller tidigare har vårdats på intensivvårdsavdelningen löper en stor risk att drabbas av svåra förvirringstillstånd, både på intensivvårdsavdelningen och i efterhand på vårdavdelningen. Tillståndet medför ofta hallucinationer, desorientering och förvirring vilket för den drabbade patienten kan upplevas som skrämmande och medföra lidande, både under sjukdomstillståndet men även i efterhand. Det är ett komplex sjukdomstillstånd där sjuksköterskan har en viktig roll genom att arbeta personcentrerat och därmed minska lidande hos patienten. Syfte. Syftet med denna studie var att undersöka patienters upplevelser av förvirring under och efter vårdtiden på intensivvårdsavdelningen. Metod. Kvalitativ studie av offentligt skrivet material vilket bearbetades med innehållsanalys. Resultat. Resultatet visade att personerna med förvirringstillstånd i samband med intensivvård genomgick obehagliga upplevelser där skräck och ångest var vanligt förekommande känslor i efterhand. Resultatet delades in i fyra kategorier; Overkliga upplevelser, desorientering, känslor under förvirringstillståndet och tiden efter förvirringstillståndet. Slutsats. Personerna beskriver upplevelsen av förvirringstillstånd i samband med intensivvård som negativ och obehaglig. Vidare beskriver flera personer en förvrängd verklighetsuppfattning där de än idag har svårigheter att avgöra vilka av upplevelserna som var verkliga och inte. Genom tolkning av resultatet kan en slutsats dras; patienters upplevelse av förvirringstillstånd i samband med intensivvård är starkt förknippat med lidande. Resultatet motiverar till ytterligare studier inom området för att förbättra kunskapen och förståelsen för hur lidandet kan minskas hos personer på vårdavdelning som har eller har haft detta förvirringstillstånd.

  • Zhou, Ang
    et al.
    Univ South Australia, Australian Ctr Precis Hlth, Adelaide, SA, Australia.
    Taylor, Amy E.
    Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England;Univ Bristol, UKCTAS, Bristol, Avon, England;Univ Bristol, Sch Expt Psychol, Bristol, Avon, England.
    Karhunen, Ville
    Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Oulu, Finland.
    Zhan, Yiqiang
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Rovio, Suvi P.
    Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
    Lahti, Jari
    Helsinki Collegium Adv Studies, Helsinki, Finland;Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland.
    Sjögren, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Lyall, Donald M.
    Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.
    Auvinen, Juha
    Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland.
    Lehtimaki, Terho
    Univ Tampere, Fac Med & Life Sci, Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
    Kahonen, Mika
    Univ Tampere, Dept Clin Physiol, Tampere Univ Hosp, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Tampere, Finland.
    Hutri-Kahonen, Nina
    Univ Tampere, Fac Med & Life Sci, Tampere, Finland;Univ Tampere, Tampere Univ Hosp, Dept Pediat, Tampere, Finland.
    Perala, Mia Maria
    Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Mahajan, Anubha
    Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford OX3 7BN, England.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Power, Chris
    UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London WC1N 1EH, England.
    Eriksson, Johan G.
    Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland;Folkhalsan Res Ctr, Helsinki, Finland.
    Raitakari, Olli T.
    Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland;Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.
    Hagg, Sara
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Pedersen, Nancy L.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Veijola, Juha
    Univ Oulu, Dept Psychiat, Res Unit Clin Neurosci, Oulu, Finland;Univ Hosp Oulu, Dept Psychiat, Oulu, Finland.
    Jarvelin, Marjo-Riitta
    Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England;Univ Oulu, Bioctr Oulu, Oulu, Finland.
    Munafo, Marcus R.
    Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England;Univ Bristol, UKCTAS, Bristol, Avon, England;Univ Bristol, Sch Expt Psychol, Bristol, Avon, England.
    Ingelsson, Erik
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford Univ, Div Cardiovasc Med, Dept Med, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
    Llewellyn, David J.
    Univ Exeter, Med Sch, Exeter, Devon, England.
    Hypponen, Elina
    Univ South Australia, Australian Ctr Precis Hlth, Adelaide, SA, Australia;UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London WC1N 1EH, England;South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.
    Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 7526Article in journal (Refereed)
    Abstract [en]

    Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid-to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (beta = -0.0007, 95% C.I. -0.009 to 0.008, P = 0.87; beta = -0.001, 95% C.I. -0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (P-heterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P >= 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.

  • Public defence: 2018-09-07 10:00 Zootissalen, Uppsala
    Kunce, Warren
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Sub-lethal Effects of Anthropogenic Contaminants on Aquatic Invertebrates2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Anthropogenic contaminants are considered to play a substantial role in the decline of freshwater invertebrate diversity. Sub-lethal effects of many of these contaminants on behaviour and life-history traits of aquatic invertebrates may contribute to their decline. As contaminants are rarely present in the environment alone, the effects of mixture exposures are highly relevant in assessing the risk these substances pose to the biota. This thesis focuses on sub-lethal effects of exposure to aquatic pollutants, separately and in combination, on fresh-water invertebrates. To investigate the single and combined effects of pesticides, larvae of the midge, Chironomus riparius were exposed to a 1 hour pulse of two neonicotinoids and two pyrethroids.  This short exposure to environmentally relevant concentrations of pesticides decreased the survival and delayed development in C. riparius.  The combination of neonicotinoids and pyrethroids did not produce synergistic effects; however, there was some indication of antagonism. Additionally, larvae of the damselfly, Coenagrion puella, were exposed for 14 hours to two environmentally relevant concentrations of pyrethroid pesticides, alone and in combination. Exposure to the pyrethroid, deltamethrin, reduced the larvae’s predatory ability. Combined exposure to both deltamethrin and esfenvalerate inhibited the Glutathione S-transferase detoxification pathway and may have additive toxic effects on the larvae’s predatory ability. Microplastics are increasingly gaining attention as an aquatic pollutant of major concern with respect to the toxicity of the microplastics themselves as well as their capacity to adsorb persistent organic pollutants like pesticides. To investigate the effects of microplastics and a pyrethroid, alone and in combination, C. riparius larvae were raised in sediment spiked with two sizes of polystyrene-based latex microbeads and an environmentally relevant concentration of esfenvalerate under normal and food-restricted conditions. Exposure to both sizes of microplastics and esfenvalerate lead to equally decreased emergence under food-restricted conditions. Additionally, exposure to esfenvalerate led to decreases in survival when food was scarce that did not occur when microplastics were co-present. Antishistamines are also an emerging aquatic contaminant of concern with very little known about their biological effects on aquatic wildlife. Antihistamines could potentially interfere with the histaminergic pathways and thus affect thermal tolerance and temperature preference in aquatic invertebrates. The freshwater snail, Planorbarius corneus, was exposed for 24 hours to the antihistamine, diphenhydramine. This exposure increased thermal tolerance and righting time, but did not affect temperature preference. The results of the investigation suggest that anthropogenic contaminates alone and/or in combination have sub-lethal effects on life history, behavior and physiology of aquatic invertebrates. Such sub-lethal effects have the potential to affect populations and community structure in the aquatic and terrestrial environment.

    List of papers
    1. Combination effects of pyrethroids and neonicotinoids on development and survival of Chironomus riparius
    Open this publication in new window or tab >>Combination effects of pyrethroids and neonicotinoids on development and survival of Chironomus riparius
    2015 (English)In: Ecotoxicology and Environmental Safety, ISSN 0147-6513, E-ISSN 1090-2414, Vol. 122, p. 426-431Article in journal (Refereed) Published
    Abstract [en]

    Standard ecotoxicological risk assessments are conducted on individual substances, however monitoring of streams in agricultural areas has shown that pesticides are rarely present alone. In fact, brief but intense pulse events such as storm water runoff and spray drift during application subject freshwater environments to complex mixtures of pesticides at high concentrations. This study investigates the potential risks to non-target aquatic organisms exposed to a brief but intense mixture of the neonicotinoid pesticides imidacloprid and thiacloprid and the pyrethroid pesticides deltamethrin and esfenvalerate, compared to single substance exposure. All four of these pesticides have been detected in surface waters at concentrations higher than benchmark values and both classes of pesticides are known to exert adverse effects on non-target aquatic organisms under single substance exposure scenarios. First instar midge larvae of the non-target aquatic organism, Chironomus riparius, were exposed to combinations of these four pesticides at 50% of their LC50 (96 h) values in a 1 h pulse. They were then reared to adulthood in uncontaminated conditions and assessed for survival, development time and fecundity. Our results show that the risk of disruption to survival and development of non-target aquatic organisms under this scenario is not negligible on account of the significant increases in mortality of C. riparius found in the majority of the pesticide exposures and the delays in development after pyrethroid exposure. While none of the deleterious effects appear to be amplified by combination of the pesticides, there is some evidence for antagonism. No effects on fecundity by any of the pesticide treatments were observed.

    Keywords
    Brief exposure, Aquatic invertebrate, Mixture toxicity, Pesticide, Midge
    National Category
    Ecology Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-268704 (URN)10.1016/j.ecoenv.2015.09.008 (DOI)000364263000053 ()26379201 (PubMedID)
    Available from: 2015-12-09 Created: 2015-12-09 Last updated: 2018-06-27Bibliographically approved
    2. Single and mixture impacts of two pyrethroids on damselfly predatory behavior and physiological biomarkers
    Open this publication in new window or tab >>Single and mixture impacts of two pyrethroids on damselfly predatory behavior and physiological biomarkers
    2017 (English)In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 190, p. 70-77Article in journal (Refereed) Published
    Abstract [en]

    Direct mortality due to toxicity of single pesticide exposure along a concentration gradient, while the most common, is only one important parameter for assessing the effects of pesticide contamination on aquatic ecosystems. Sub-lethal toxicity can induce changes in an organism's behavior and physiology that may have population -level ramifications and consequences for ecosystem health. Additionally, the simultaneous detection of multiple contaminants in monitored watersheds stresses the importance of gaining a greater understanding of the toxicities of combined exposures, particularly at low, environmentally relevant concentrations. Using larvae of the Azure Damselfly (Coenagrion paella), we conducted a combined exposure investigation of two widely-used pyrethroid insecticides presumed to share the same neurotoxic mechanism of action, and estimated their effect on predatory ability, mobility and three physiological biomarkers (Glutathione S-transferase; GST, respiratory electron transport system; ETS, and malondialdehyde; MDA). Deltamethrin exposure (0.065 mu g/L and 0.13 mu g/L) was found to reduce the predatory ability, but it did not affect the larvae's mobility. Esfenvalerate exposure (0.069 mu g/L and 0.13 mu g/L), on the other hand, induced no significant changes in predatory ability or mobility. The decrease in predatory ability after the combination exposure (0.067 mu g/L deltamethrin and 0.12 mu g/L. esfenvalerate) did not significantly differ from the impact of the single deltamethrin exposures. Glutathione-S-transferase was induced after single esfenvalerate exposure and the lower deltamethrin concentration exposure, but seemingly inhibited after exposure to the higher concentration of deltamethrin as well as the combination of both pyrethroids. Our data indicate that sub-lethal exposure to deltamethrin reduces predatory ability and suggest that sub-lethal combined exposure to deltamethrin and esfenvalerate inhibits the GST detoxification pathway. These effects can eventually result in a lower emergence of adults from contaminated ponds.

    Place, publisher, year, edition, pages
    Elsevier, 2017
    Keywords
    Pesticides, Combination exposure, behavior, Sub-lethal effects, Aquatic invertebrate, Biomarkers
    National Category
    Pharmacology and Toxicology Other Biological Topics
    Identifiers
    urn:nbn:se:uu:diva-335643 (URN)10.1016/j.aquatox.2017.06.025 (DOI)000408783600009 ()28692868 (PubMedID)
    Available from: 2017-12-08 Created: 2017-12-08 Last updated: 2018-06-27Bibliographically approved
    3. Combined effects of microplastics and a pyrethroid on the benthic invertebrate, Chironomus Riparius
    Open this publication in new window or tab >>Combined effects of microplastics and a pyrethroid on the benthic invertebrate, Chironomus Riparius
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    There is growing evidence of widespread contamination of freshwater ecoystems with microplastics, plastic polymers that are < 5 mm. While a wide variety of organisms have been reported to ingest microplastics, the biological effects of chronic microplastic ingestion are not well understood.  Microplastics can adsorb organic pollutants in aqueous environments which made lead to increased exposure to these chemicals if desorption occurs after ingestion. Alternatively, relatively clean microplastics may adsorb chemicals in the gut decreasing their bioavailability. This study investigates the effects of chronic sediment exposure to latex-based polystyrene microspheres alone and in combination with the pyrethroid pesticide, esfenvalerate, on the life-history traits of the benthic invertebrate, Chironomus riparius, under two scenarios: abundant food and limited food. We found that chronic sediment exposure to 1.0 and 10.0 µm latex-based polystyrene latex microspheres, a low concentration of esfenvalerate and a combination of the 1.0 µm microspheres and esfenvalerate led to no significant effects on survival, development time, emergence, or sex of C. riparius when food was abundant. However, effects of exposure did become apparent when food was insufficient indicating that these contaminants may be stressors with an energy cost to the organism.

    National Category
    Biological Sciences
    Identifiers
    urn:nbn:se:uu:diva-354695 (URN)
    Available from: 2018-06-21 Created: 2018-06-21 Last updated: 2018-06-27
    4. Effects of acute antihistamine exposure on thermal tolerance and behaviour in the freshwater snail, Planorbarius corneus
    Open this publication in new window or tab >>Effects of acute antihistamine exposure on thermal tolerance and behaviour in the freshwater snail, Planorbarius corneus
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Antihistamine pollutants have the potential to interfere with the normal functioning of aquatic organisms due to their intentionally bio-active nature. Histamine is a neurotransmitter present in multiple tissues in both vertebrates and invertebrates and histaminergic pathways have been identified in the thermoregulatory processes of invertebrates. Disruption of normal histamine functioning via exposure to the widespread antihistamine pollution observed in fresh waters may induce a range of sub-lethal effects on aquatic invertebrates including thermoregulatory and behavioural changes. We conducted three experiments exposing freshwater snails (Planorbarius corneus) to the antihistamine, diphenhydramine, for 24 hours then evaluating thermal tolerance, temperature preference and righting time. Diphenhydramine was found to increase thermal tolerance and righting time, but did not affect temperature preference. These results warrant further investigation into the biological effects of antihistamines on aquatic wildlife as well as altered thermal tolerance and thermoregulation as relevant toxicological endpoints in ecotoxicological risk assessment of pharmaceuticals.

    National Category
    Biological Sciences
    Identifiers
    urn:nbn:se:uu:diva-354696 (URN)
    Available from: 2018-06-21 Created: 2018-06-21 Last updated: 2018-06-27
  • Public defence: 2018-09-07 13:25 Häggsalen, Uppsala
    Yang, Jiaojiao
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Amorphous magnesium carbonate nanomaterials: Synthesis, characterization and applications2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    High surface-to-volume ratio materials, including nanoparticles and mesoporous materials, have a number of applications due to their large surface area and special structures. Traditional approaches for synthesizing high surface-to-volume ratio nanomaterials are often complicated, expensive or environmentally unfriendly. Considering aspects such as availability and safety in terms of environmental or biological contact, magnesium carbonate-based nanomaterials are an interesting and potentially valuable candidate for novel applications. The overall aim of this thesis was to develop novel high surface-to-volume ratio amorphous magnesium carbonate nanomaterials and investigating their possible applications.

    Amorphous magnesium carbonate nanoparticles (AMN) were successfully synthesized via a simple and low-temperature pathway. The structure and resulting properties of the material can be tailored by changing the final steps in the synthesis process.

    The ability of AMN to stabilize ibuprofen (IBU) in the amorphous state was investigated. Nanocomposites with IBU:AMN mass ratios as high as to 5:1 were shown to enhance the release rate of IBU in vitro by as much as 83 times compared to IBU in crystalline form. A related nanostructured material, mesoporous magnesium carbonate (MMC), was evaluated as a drug carrier for stabilizing amorphous drugs through the incorporation of the drug within its pores. In this study, MMC was used to release and sustain two poorly soluble drugs (tolfenamic acid and rimonabant) in the supersaturated state with the assistance of hydroxypropyl methylcellulose.

    AMN was also used to synthesize a novel adhesive together with IBU without the addition of a polymer. This adhesive was transparent, self-healing, shapeable, stretchable and reusable. In addition, the adhesive was able to glue a variety of materials, including metals, glass, paper and plastics (even Teflon).

    Finally, AMN was used to prepare flexible, transparent and UV-shielding films when incorporated into a PMMA matrix. These films exhibited both UV-shielding properties and moisture absorbance and retention abilities. In addition, the UV- and thermo-stability of these films were enhanced by the addition of AMN.

    The work presented in this thesis show that the nanomaterials AMN and MMC possess great potential for an extremely broad range of applications, from pharmaceutical applications dealing with poorly soluble drugs to structural applications such as adhesives to applications in optics or electronics such as UV-shielding or moisture barrier films.

    List of papers
    1. Synthesis and Characterization of Amorphous Magnesium Carbonate Nanoparticles
    Open this publication in new window or tab >>Synthesis and Characterization of Amorphous Magnesium Carbonate Nanoparticles
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-354505 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    2. Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen
    Open this publication in new window or tab >>Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-354506 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    3. Enhanced UV protection and water adsorption properties of transparent poly(methyl methacrylate) films through incorporation of amorphous magnesium carbonate nanoparticles
    Open this publication in new window or tab >>Enhanced UV protection and water adsorption properties of transparent poly(methyl methacrylate) films through incorporation of amorphous magnesium carbonate nanoparticles
    (English)Manuscript (preprint) (Other academic)
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-354510 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    4. Adhesives from Inorganic Nanoparticles and Low-Molecular-Weight Organic Compounds
    Open this publication in new window or tab >>Adhesives from Inorganic Nanoparticles and Low-Molecular-Weight Organic Compounds
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-354509 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    5. Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers
    Open this publication in new window or tab >>Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers
    Show others...
    2017 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 525, no 1, p. 183-190Article in journal (Refereed) Published
    Abstract [en]

    Abstract The need to combat poor water solubility has increased interest in supersaturating drug delivery systems. In this study, amorphous mesoporous magnesium carbonate (MMC) was used as a drug carrier to achieve supersaturation of tolfenamic acid and rimonabant, two drug compounds with low aqueous solubility. The potential synergy between MMC and hydroxypropyl methylcellulose (HPMC), a polymer commonly included as a precipitation inhibitor in drug delivery systems, was explored with the aim of extending the time that high supersaturation levels were maintained. Release was studied under physiological conditions using USP-2 dissolution baths. A new small-scale method was developed to enable measurement of the initial drug release occurring when the MMC is immersed in the water phase. It was shown that MMC and HPMC together resulted in significant supersaturation and that the polymer enabled both the achievement of a higher API concentration and extension of the supersaturation period. The new small-scale release method showed that the release was linearly increasing with the dose and that similar release rates were observed for the two model compounds. It was hence concluded that the MMC release was diffusion limited for the compounds explored.

    Keywords
    Magnesium carbonate, Mesoporous, Hydroxypropyl methylcellulose, Tolfenamic acid, Rimonabant, Supersaturation
    National Category
    Nano Technology
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-320987 (URN)
    Available from: 2017-04-27 Created: 2017-04-27 Last updated: 2018-06-20
  • Salin Gustafsson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Frost, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Operational management through key performance Indicators: A case study performed at the warehouses at Fresenius Kabi2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Purpose: The purpose of this study is to identify and develop relevant keyperformance indicators within the warehouse operations in amanufacturing company, and how they can be used for control. Research question: In a manufacturing company, which are the most important KPIs forcontrolling and monitoring the warehouse operations, and how can thoseKPIs be developed?Methodology: This master thesis is based on a case study at a pharmaceutical companynamed Fresenius Kabi. A qualitative approach has been used whereprimary data was collected through 10 structured & semi structuredinterviews and through observations in the warehouses to understand thecurrent state. Secondary data was used in form of academic papers to seewhat previous research had to say about KPIs and operation & processmanagement. Internal documents were also used as a secondary source. Findings: Two key performance indicators have been developed, productivity andcost efficiency. A template has been designed to produce the KPIs. Thisstudy contributes to the understanding of how to develop KPIs that fits amanufacturing company´s warehouse operations and a recommendation onhow you could develop a system for producing the data.

  • Älvebrink, Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Jansson, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Investigation of blockchain applicability to Internet of Things within supply chains2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Internet of Things (IoT) means that physical objects will be able to interact and communicate via embedded systems. This will lead to a distributed network of devices that can communicate with both humans and each other. One application area is in improving supply chain management. The goal in supply chains is to move a product or a service from the producer to the customer as efficient as possible. Implementation of IoT will have many benefits but it also raises security issues that can affect integrity, security and privacy for both individuals and companies.

    In 2009, Satoshi Nakamoto created bitcoin and more importantly, blockchain. Blockchain is a ledger of facts, data is not stored in only one network with a common processor, but it is distributed among all the clients on the network. This technology may be a solution to some problems that IoT are facing.

    This paper looks into up to date research of blockchain and IoT with the purpose to study blockchain as a potential solution to secure IoT data management within supply chains. Both blockchain and IoT are relatively new research areas with little existing research, which support our use of a qualitative inductive method. Semi-structured interviews, which will be further explained in the methodology section, have been conducted with people working within the fields of blockchain, IoT and supply chain.

    The result indicates that blockchain can be used to secure data management within any given supply chain that uses IoT technology, but blockchain should be seen as a tool, and not as a complete solution. Many of the security issues within IoT are related to the devices and blockchain will not be able to provide a solution to these problems. Blockchain can however be used for handling information, securing identities, traceability of goods, transactions being made without human interaction, automated storage management and time stamped actions to name some examples. There are still barriers to make these benefits work in reality but there is a lot of research currently on-going, trying to make it happen.

  • Public defence: 2018-09-07 13:15 Polhemsalen, Uppsala
    Zimmermann, Jakob
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Classification of simple transitive 2-representations2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The representation theory of finitary 2-categories is a generalization of the classical representation theory of finite dimensional associative algebras. A key notion in classical representation theory is the notion of simple modules as those are in some sense the building blocks of all modules. A correct analogue of simple modules in the realm of 2-representations is the notion of simple transitive 2-representations since those also turn out to be building blocks of 2-representations.

    This thesis is concerned with the classification of simple transitive 2-representations for a number of different interesting 2-categories. In Paper I we study simple transitive 2-representations of Soergel bimodules in Coxeter type I2(4) and show that all simple transitive 2-representations in this case are equivalent to cell 2-representations. In Paper II we classify simple transitive 2-representations for the quotient of the 2-category of Soergel bimodules over the coinvariant algebra which is associated to the two-sided cell that is the closest to the two-sided cell containing the identity element, in all Coxeter types but I2(12), I2(18) and I2(30). It turns out that, in most of the cases, simple transitive 2-representations are exhausted by cell 2-representations. However, in Coxeter types I2(2k), where k ≥ 3, there exist simple transitive 2-representations which are not equivalent to cell 2-representations. In Paper III we show that for any complex polynomial p(X) the set of irreducible, integer matrices which are annihilated by p(X) is finite. Moreover, we study the set of irreducible, integral matrices satisfying X² = nX, for n ≥ 1, and count its elements. In Paper IV we show that every simple transitive 2-representations of the 2-category of projective functors for a certain quotient of the quadratic dual of the preprojective algebra associated with a tree is equivalent to a cell 2-representation. Finally, in Paper V we study simple transitive 2-representations of certain 2-subcategories of the 2-categories of projective functors over star algebras. In the simplest case, which is associated with Dynkin type A2, we show that simple transitive 2-representations are classified by cell 2-representations. However, in the general case we conjecture that there exist many more simple transitive 2-representations.

    List of papers
    1. Simple transitive 2-representations of left cell 2-subcategories of projective functors for star algebras
    Open this publication in new window or tab >>Simple transitive 2-representations of left cell 2-subcategories of projective functors for star algebras
    (English)In: Communications in Algebra, ISSN 0092-7872, E-ISSN 1532-4125Article in journal (Refereed) Submitted
    Abstract [en]

    In this paper we study simple transitive 2-representations of certain 2-subcategories of the 2-category of projective functors over a star algebra. We show that in the simplest case, which is associated to the Dynkin type A2, simple transitive 2-representations are classified by cell 2-representations. In the general case we conjecture that there exist many simple transitive 2-representations which are not cell 2-representations and provide some evidence for our conjecture.

    National Category
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-354589 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    2. Simple transitive 2-representations of Soergel bimodules in type B2
    Open this publication in new window or tab >>Simple transitive 2-representations of Soergel bimodules in type B2
    2017 (English)In: Journal of Pure and Applied Algebra, ISSN 0022-4049, E-ISSN 1873-1376, Vol. 221, no 3, p. 666-690Article in journal (Refereed) Published
    Abstract [en]

    We prove that every simple transitive 2-representation of the fiat 2-category of Soergel bimodules (over the coinvariant algebra) in type B2 is equivalent to a cell 2-representation. We also describe some general properties of the 2-category of Soergel bimodules for arbitrary finite dihedral groups.

    National Category
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-354583 (URN)10.1016/j.jpaa.2016.07.011 (DOI)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    3. Simple transitive 2-representations of some 2-categories of projective functors
    Open this publication in new window or tab >>Simple transitive 2-representations of some 2-categories of projective functors
    2018 (English)In: Beiträge zur Algebra und Geometrie, ISSN 0138-4821, Vol. 59, no 1, p. 41-50Article in journal (Refereed) Published
    Abstract [en]

    We show that every simple transitive 2-representation of the $2$-category of projective functors for a certain quotient of the quadratic dual of the preprojective algebra associated with a tree is equivalent to a cell 2-representation.

    Place, publisher, year, edition, pages
    Berlin/Heidelberg: Springer Berlin/Heidelberg, 2018
    Keywords
    Representation theory, 2-category, Simple transitive 2-representation, Cell 2-representation
    National Category
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-354581 (URN)10.1007/s13366-017-0348-4 (DOI)000431552200004 ()
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-07-04Bibliographically approved
    4. Simple transitive 2-representations of small quotients of Soergel bimodules
    Open this publication in new window or tab >>Simple transitive 2-representations of small quotients of Soergel bimodules
    (English)In: Transactions of the American Mathematical Society, ISSN 0002-9947, E-ISSN 1088-6850Article in journal (Refereed) Accepted
    Abstract [en]

    In all finite Coxeter types but I2(12), I2(18) and I2(30), we classify simple transitive 2-representations for the quotient of the 2-category of Soergel bimodules over the coinvariant algebra which is associated to the two-sided cell that is the closest one to the two-sided cell  containing the identity element. It turns out that, in most of the cases, simple transitive 2-representations are exhausted by cell 2-representations. However, in Coxeter types I2(2k), where k ≥ 3, there exist simple transitive 2-representations which are not equivalent to cell 2-representations.

    National Category
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-354594 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
    5. Counting Quasi-idempotent Irreducible Integral Matrices
    Open this publication in new window or tab >>Counting Quasi-idempotent Irreducible Integral Matrices
    2018 (English)In: Journal of Integer Sequences, ISSN 1530-7638, E-ISSN 1530-7638, Vol. 21, no 4, article id 18.4.48Article in journal (Refereed) Published
    Abstract [en]

    Given any polynomial p in C[X], we show that the set of irreducible matrices satisfying p(A)=0 is finite. In the specific case p(X)=X2-nX, we count the number of irreducible matrices in this set and analyze the arising sequences and their asymptotics. Such matrices turn out to be related to generalized compositions and generalized partitions.

    National Category
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-354586 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-06-20
  • Moreno Gay, Ariadna
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Introduction, evaluation and implementation of health-associated technologies into municipalities: A situation analysis targeting municipalities, companies and end-users’ perspectives in Sweden2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Research questions:

    I: What are the key steps to introduce, evaluate and implement health-associated technologies into different Swedish municipalities?

    II: Which are the main challenges and opportunities to introduce, evaluate and implement health-associated technologies into different Swedish municipalities?

    Purpose: The aim of the project has been to conduct a situation analysis on how different Swedish municipalities introduce, evaluate and implement existing health-associated technologies into their organization. To conduct this study, key steps and main challenges in these processes have been identified by interviewing different stakeholders involved from the public and private sector as well as end users.

    Methodology: This master thesis is an abductive case study. Primary data has been collected through interviews and internal documents from organizations. Secondary data collection was collected through research papers and literature review.

    Findings: The main findings of this study show that regarding the introduction procedure some municipalities are further in the process of developing formal procedures for organizations and end users to approach them with their products or needs. The evaluation as part of the procurement process has been considered a big obstacle for the three stakeholders groups interviewed since the criteria established doesn’t consider the different aspect of the technology as its value to the municipality and end user. Implementation procedures do not exist and were not under development from any of the three municipalities interviewed.

    Keywords: Innovation process, municipalities, healthcare, technology, public sector, private sector, end-users.

  • Sumaya, Wael
    et al.
    Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Gabrysch, Katja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Bertilsson, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Himmelmann, Anders
    AstraZeneca Res & Dev, Gothenburg, Sweden..
    Ajjan, Ramzi A.
    Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England..
    Storey, Robert F.
    Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England..
    Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy2018In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, no 13, p. 1078-1085Article in journal (Other academic)
    Abstract [en]

    Aims To determine whether fibrin clot properties are associated with clinical outcomes following acute coronary syndrome (ACS). Methods and results Plasma samples were collected at hospital discharge from 4354 ACS patients randomized to clopidogrel or ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. A validated turbidimetric assay was employed to study plasma clot lysis time and maximum turbidity (a measure of clot density). One-year rates of cardiovascular (CV) death, spontaneous myocardial infarction (MI) and PLATO-defined major bleeding events were assessed after sample collection. Hazard ratios (HRs) were estimated using Cox proportional hazards models. After adjusting for CV risk factors, each 50% increase in lysis time was associated with CV death/spontaneous MI [HR 1.17, 95% confidence interval (CI) 1.05-1.31; P < 0.01] and CV death alone (HR 1.36, 95% CI 1.17-1.59; P < 0.001). Similarly, each 50% increase in maximum turbidity was associated with increased risk of CV death (HR 1.24, 95% CI 1.03-1.50; P = 0.024). After adjustment for other prognostic biomarkers (leukocyte count, high-sensitivity C-reactive protein, high-sensitivity troponin T, cystatin C, N-terminal pro B-type natriuretic peptide, and growth differentiation factor15), the association with CV death remained significant for lysis time (HR 1.2, 95% CI 1.01-1.42; P = 0.042) but not for maximum turbidity. These associations were consistent regardless of randomized antiplatelet treatment (all interaction P > 0.05). Neither lysis time nor maximum turbidity was associated with major bleeding events. Conclusion Fibrin clots that are resistant to lysis independently predict adverse outcome in ACS patients. Novel therapies targeting fibrin clot properties might be a new avenue for improving prognosis in patients with ACS.

  • Lexelius, Rebecka
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Formation of Monolayered Phospholipids using Molecular Dynamics2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The very fundamental properties of biological membranes can be understood by studying their formation. This sets a good foundation for research related to how the membranes interact with organic molecules and ions; something of great value in the quest of explaining transport phenomena through cell membranes. It is furthermore of growing interest within the pharmacological research and contributes to the apprehension of life at the molecular level. In this thesis Molecular Dynamics has been used to simulate how evenly distributed phospholipids solvated in water leads to the formation of monolayers. An automation program has been written in Python for performing these simulations and is to be used as the foundation for performing simulations in further studies. The program was used to simulate model systems of high- and low concentrations of DPPC lipids. The DPPC lipid, like most other lipids, consist of a hydrophilic "head" part and two lipophilic "tails", which is the main cause of the lipids interacting in such a manner that forms membranes. The low concentration system was simulated for a total of 3 ns with all lipids having reached the surface at 1.5 ns, and the all lipids in the high concentration system had risen at 41 ns with a total simulation time of 43 ns.

  • Tärnlund, Sten-Åke
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    P is not equal to NP2018Report (Other academic)
    Abstract [en]

    Axiom 1 extends Turing’s, first order, theory of computing, so, computations are proofs in Robinson resolution. Then, SAT is not in P, is proved using Hilbert’s proof theory. Therefore, P is not equal to NP.

  • Lindstrom, Ida
    et al.
    Stockholm Univ, Dept Biochem & Biophys.
    Andersson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Dogan, Jakob
    Stockholm Univ, Dept Biochem & Biophys.
    The transition state structure for binding between TAZ1 of CBP and the disordered Hif-1 alpha CAD2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 7872Article in journal (Refereed)
    Abstract [en]

    Intrinsically disordered proteins (IDPs) are common in eukaryotes. However, relatively few experimental studies have addressed the nature of the rate-limiting transition state for the coupled binding and folding reactions involving IDPs. By using site-directed mutagenesis in combination with kinetics measurements we have here characterized the transition state for binding between the globular TAZ1 domain of CREB binding protein and the intrinsically disordered C-terminal activation domain of Hif-1 alpha (Hif-1 alpha CAD). A total of 17 Hif-1 alpha CAD point-mutations were generated and a F-value binding analysis was carried out. We found that native hydrophobic binding interactions are not formed at the transition state. We also investigated the effect the biologically important Hif-1 alpha CAD Asn-803 hydroxylation has on the binding kinetics, and found that the whole destabilization effect due the hydroxylation is within the dissociation rate constant. Thus, the rate-limiting transition state is "disordered-like", with native hydrophobic binding contacts being formed cooperatively after the rate-limiting barrier, which is clearly shown by linear free energy relationships. The same behavior was observed in a previously characterized TAZ1/IDP interaction, which may suggest common features for the rate-limiting transition state for TAZ1/IDP interactions.

  • Nordman, David
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Cs-137 i Svamp: Dataanalysrutiner för gammaspektroskopi2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The nuclear disaster in Chernobyl brought radioactive substances over Europe and Sweden. In 2018 it has passed 32 years since the disaster and the only radioactive isotope that reamins in the swedish ecosystem at a signicant level is Cs-137. By determining activity of mushroom, the amount of Cs-137 in the ground can be estimated. In the fall of 2018, the interdisciplinary mass-experiment Strålande jord will take place with the purpose to map this amount all over Sweden. The purpose of this work was to reach results that could be of use when determining the activity of mushroom.

    A numerical tool for analysing data from gamma spectroscopy has been constructed. Two different methods for calculating counts in energy peaks from gamma emission spectra have been made and have been the basis for the further work. During this work the following has been determined: The efficiency of a high purity germanium (HPGe) detector, the activity of two different mushroom samples, the attenuation coefficient of gamma at 662 keV for these samples and for water.

    In order to be able to approximate a can filled with mushroom as an isotropic radiating point source and get accurate results, the activity measurements need to be carried out with a great distance between the sample and the detector. A consequence of this is that this approximation is only suitable for high-activity mushroom, which became evident when the activity of a low-activity mushroom could not be decided with decent statistics even though single measurements were carried out in almost a weeks time. Systematic errors are not considered during this work, only statistical uncertainties.

  • Hembäck, Theo
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Al Mizori, Omar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Ställtidsreduktion på S:t Eriks i Vara: SMED-analys på maskin T22018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Improvements in reducing changeover time(that is, the time ittakes to change production from one product variant to another) isan important part for the optimization of production as it entailsa more flexible production and reduced inventory costs. S:t EriksAB in Vara are investigating the possibilities of reducing thechangeover time for one of their machines that manufacturesconcrete slabs in two sizes; 35x35cm and 50x50cm. It is thechangeover between these different products that is the main focusof this paper and the goal is to halve the changeover time.The research is based on SMED (Single Minute Exchange of Die), amethod which was developed by Shigeo Shingo during his time atToyota. It was made specifically for changeover reduction and isan important part of Lean manufacturing. The preparatory workconsisted mainly of literary studies, the purpose of which was togain knowledge regarding which types of data that needed to becollected during the observation of the changeover. The collectionof the data consisted in empirical studies which were documentedin the form of handwritten notes, photography and video capturing.Conversations with various employees complemented some of thecollected data.The results consists of documentation regarding the relevantcomponents of the machine and the operations of the changeover,whom are divided into external and internal operations. A coupleof suggestions for conversions from internal to externaloperations where put forth and which of the operations that couldbe performed parallel to each other. All of these suggestions werecompiled into a work schedule which suggests that a halving of thechangeover time is possible. Suggestions regarding safety,ergonomics and standardisation of some of the operations werepresented in the form of tooling stations, standardisation offasteners, standardisation of the positioning of components andthe introduction of a traverse and travelators. The potentialimprovement if all of the suggestions are implemented werevisualized in two spaghetti diagram whom contrasted the movementpatterns before and after

  • Public defence: 2018-09-07 10:15 Häggsalen, Uppsala
    Zhang, Teng
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Synchrotron Radiation Studies of Molecular Building Blocks for Functional Materials2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The research on new materials is a primary driving force for progress in human society. One of the most significant research topic nowadays is the development of new functional materials for technological applications, like perovskite implemented in solar cells, and graphene as a representative for the new 2D materials family. It is then crucial to fully understand the functionality of such materials from a fundamental point of view, as a complementary and useful guide to develop/design new devices of improved performance and energy efficiency.

    In the thesis, comprehensive characterizations of molecular building blocks used in i) novel energy conversion devices (CoPc, TPA, DPTA and m-MTDATA), and ii) in 2D materials (biphenylene and melamine) have been performed by PhotoElectron Spectroscopy (PES), and Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy carried out at synchrotron radiation facilities, representing effective, powerful light source dedicated to the front-line materials research of great value in both science and industry. PES and NEXAFS spectroscopy, in combination with Density Functional Theory (DFT) calculations have provided a deep understanding of the electronic structure of the investigated systems in relation to their functionality. The investigations always included the combination and comparison between experimental and theoretical results. The studied molecules were characterized as free and adsorbed on surfaces, from the simple building blocks to more complex molecular systems. The characterizations allowed us to identify the electronic structure modifications due to substitutions (Paper III), increasing complexity of the molecules (Paper V), molecule-substrate interactions (Paper I, II, IV, V) and intra-molecular H-bonding interactions (Paper VI).

    List of papers
    1. Conclusively Addressing the CoPc Electronic Structure: A Joint Gas-Phase and Solid-State Photoemission and Absorption Spectroscopy Study
    Open this publication in new window or tab >>Conclusively Addressing the CoPc Electronic Structure: A Joint Gas-Phase and Solid-State Photoemission and Absorption Spectroscopy Study
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    2017 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 121, no 47, p. 26372-26378Article in journal (Refereed) Published
    Abstract [en]

    The occupied and empty densities of states of cobalt phthalocyanine (CoPc) were investigated by photoelectron and X-ray absorption spectroscopies in the gas phase and in thin films deposited on a Au(111) surface. The comparison between the gas-phase results and density functional theory single-molecule simulations confirmed that the CoPc ground state is correctly described by the (2)A(1g) electronic configuration. Moreover, photon-energy-dependent valence photoemission spectra of both the gas phase and thin film confirmed the atomic character of the highest occupied molecular orbital as being derived from the organic ligand, with dominant contributions from the carbon atoms. Multiplet ligand-field theory was employed to simulate the Co L-edge X-ray absorption spectroscopy results.

    Place, publisher, year, edition, pages
    AMER CHEMICAL SOC, 2017
    National Category
    Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-344315 (URN)10.1021/acs.jpcc.7b08524 (DOI)000417228500026 ()
    Funder
    Swedish Research CouncilCarl Tryggers foundation
    Available from: 2018-03-08 Created: 2018-03-08 Last updated: 2018-06-29Bibliographically approved
    2. Electronic structure investigations of biphenylene films
    Open this publication in new window or tab >>Electronic structure investigations of biphenylene films
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    (English)Article in journal (Refereed) Submitted
    Abstract [en]

    Photoelectron Spectroscopy (PES) and Near-Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy have been used to investigate the occupied and empty density of states of biphenylene films of different thicknesses, deposited onto a Cu(111) crystal. The obtained results have been compared to previous gas phase spectra and single molecule density functional theory (DFT) calculations to get insights into the possible modification of the molecular electronic structure in the film induced by the adsorption on a surface. Furthermore, NEXAFS measurements allowed characterizing the variation of the molecular arrangement with the film thickness and helped to clarify the substrate- molecule interaction. 

    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:uu:diva-307784 (URN)
    Available from: 2016-11-21 Created: 2016-11-21 Last updated: 2018-06-29
    3. Lone Pair Delocalization Effect within Electron Donor Molecules: The Case of Triphenylamine (TPA) and Its Thiophene-Analog (DPTA)
    Open this publication in new window or tab >>Lone Pair Delocalization Effect within Electron Donor Molecules: The Case of Triphenylamine (TPA) and Its Thiophene-Analog (DPTA)
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    (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455Article in journal (Refereed) Submitted
    Abstract [en]

    Triphenylamine (TPA) and its thiophene-analog, N,N-Diphenyl-2-thiophenamine (DPTA), are both well known as electron-donating molecules implemented in optoelectronic devices such as organic solar cells and LEDs. Comprehensive valence and core level PhotoElectron Spectroscopy (PES), as well as Near Edge X-ray Absorption Spectroscopy (NEXAFS) measurements have been performed on gas-phase TPA and DPTA. The experimental results have been compared to Density Functional Theory (DFT) calculations, providing a detailed description of the molecular electronic structure. Specifically, the C 1s photoelectron lines of both TPA and DPTA were resolved in the different C atom contributions and their binding energies explained as the result of two counter-acting effects: (1) the electronegativity of the nitrogen atom (and sulphur atom in DPTA) and (2) the delocalization of the N (and S in DPTA) lone pair electrons. In addition, the C K-edge NEXAFS spectrum of DPTA reveals that the Lowest Unoccupied Molecular Orbital (LUMO) energy position is affected differently if the core-hole site is on the phenyl compared to the thiophene ring. The electron-donating properties of these two molecules are largely explained by the significant contribution of the N lone pair electrons (pz) to the Highest Occupied Molecular Orbital (HOMO). The contribution to the LUMO and to the empty density of states of the sulphur of the thiophene ring in DPTA explains the better performance of Donor-π-Acceptor molecules containing this moiety and implemented in photo-energy conversion devices.

    National Category
    Physical Sciences
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-355118 (URN)
    Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29
    4. X-ray Spectroscopy Investigations of TPA/Au(111): Charge Redistribution via Core Exitation?
    Open this publication in new window or tab >>X-ray Spectroscopy Investigations of TPA/Au(111): Charge Redistribution via Core Exitation?
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Triphenylamine (TPA) is a well-known electron donor molecule largely used in photovoltaics. In this article we analyze the electronic structure modifications due to the adsorption of the molecules at a monolayer coverage on a Au(111) surface. Only a weak interaction was observed between the TPA and the gold during the adsorption process, being impossible to get more than 1ML coverage at room temperature. The characterizations have been performed by core and valence Photoelectron Spectroscopy (PES) and Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy. The results were compared with our previous investigations on free TPA, and theoretical models were used to explain the changes of the electronic structure due to the adsorption on the metallic gold surface. The calculation confirms the weak interaction between the adsorbed TPA and the Au(111), with only a slight change of the twisting angle of the TPA phenyl rings. The resulting adsorption geometry can be used to explain the broadening of the C 1s PES line with respect to the gas-phase results and the expected absence of angle dependence in the C K-edge NEXAFS. However, a significant modification was observed in the N K-edge NEXAFS spectra of TPA/Au(111), showing a new pre-edge feature due to transitions involving out-of-plane orbitals. This pre-edge feature is ascribed to the interaction between the molecules and the surface, having a different character and energy position than the pre-edge observed for free TPA. A model, considering a TPA+ cation formed by a charge redistribution process between the adsorbate and the surface valence states seems to give a qualitative explanation of this pre-edge intensity. Since our calculations predict only a weak interaction between the TPA molecules and the gold surface, we propose that such a charge redistribution happens in the core-excited state created by photon absorption.

    National Category
    Physical Sciences
    Identifiers
    urn:nbn:se:uu:diva-355120 (URN)
    Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29
    5. Electronic Structure Study of Free and Adsorbed m-MTDATA
    Open this publication in new window or tab >>Electronic Structure Study of Free and Adsorbed m-MTDATA
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The starburst p-conjugated molecule based on triphenylamine (TPA) building block, 4,4',4" -Tris(N-3-methylphenyl-N-phenyl-amino)triphenylamine (m-MTDATA), is widely used in optoelectronic devices due to its electron-donating properties. The electronic structure of m-MTDATA was investigated in the gas-phase and when deposited in thin films on a Au(111) surface by means of PhotoElectron Spectroscopy (PES) and Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy. Density Functional Theory (DFT) calculations were compared to the experimental gas-phase results, providing a comprehensive description of the molecular electronic structure. Moreover, the results were compared with previous TPA measurements, shedding light on the electronic structure modification due to the increased molecular complexity.  Similar to TPA, but more complex, the binding energy of the C 1s photoelectron line of m-MTDATA results from the balance of two counter-acting effects: (1) the electronegativity of the N atoms and (2) the delocalization of lone-pair electrons of the nitrogen. Compared to TPA, the outermost valence PE spectrum of m-MTDATA shows a 3-peak feature with N 2pz character and a lowering of the binding energy of the HOMO. When adsorbed on Au(111),  the changes observed in PES and NEXAFS spectra with respect to the free molecules,  can be explained by a significant modification of m-MTDATA molecular and electronic structure, due to the molecule-substrate interaction.

    National Category
    Physical Sciences
    Identifiers
    urn:nbn:se:uu:diva-355121 (URN)
    Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29
    6. Spectroscopic Fingerprints of Carbon Nitride Functional Groups Locked-up in Intermolecular H-bonding Interactions
    Open this publication in new window or tab >>Spectroscopic Fingerprints of Carbon Nitride Functional Groups Locked-up in Intermolecular H-bonding Interactions
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    (English)In: Chemistry: A European Journal, ISSN 0947-6539Article in journal (Refereed) Submitted
    Abstract [en]

    We have investigated the effect of intermolecular H- bonding interactions on the local electronic structure of N- functionalities, amino group and pyridine-like N, which are characteristic of a new class of metal-free polymeric photo-catalysts named graphitic carbon nitrides, g-C3N4. Specifically, we have performed a characterization of the melamine molecule, a building block of g-C3N4, combining X-ray photoemission (XPS) and near edge X-ray absorption fine structure (NEXAFS) spectroscopy. The molecule has been studied in the gas phase, as non-interacting system, and in the solid state within a hydrogen bonded network. With the support of density functional theory (DFT) simulations of the spectra, we have found that the H-bonds mainly affect the N 1s level of the amino group, leaving the N 1s level of the pyridine-like N mostly unperturbed. This fact is responsible for a reduction of the chemical shift between the two XPS N 1s levels, compared to the free melamine. Consequently, N K-edge NEXAFS resonances involving the amino N 1s level also shift to lower photon energies. Moreover, the solid state absorption spectra have shown strong modification/quenching of resonances related with transitions from the amino N 1s level towards σ*orbitals involving the -NH2 terminations. 

    National Category
    Physical Sciences
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-355123 (URN)
    Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29
  • Leijon, Jennifer
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Boström, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Freshwater production from the motion of ocean waves - A review2018In: Desalination, ISSN 0011-9164, E-ISSN 1873-4464, Vol. 435, p. 161-171Article, review/survey (Refereed)
    Abstract [en]

    Freshwater scarcity and insufficient sanitation are global urgent problems, affecting billions of people. In this review paper, the process of desalination powered by wave power has been investigated as a potential sustainable solution to water shortage. The different desalination techniques suitable for this type of combined system, i.e. reverse osmosis, electrodialysis and mechanical vapor compression, have been outlined, as well as the different wave energy converters possible to power the desalination process, i.e. oscillating water columns, oscillating bodies (wave activated bodies) and overtopping systems. Some necessary considerations for this type of project are identified. The different wave power/desalination projects and how they have proceeded are presented. The most common design of a wave energy and desalination system includes a wave activated body to pressurize seawater; the seawater flows through a reverse osmosis membrane, resulting in freshwater. Some successful (freshwater producing) wave energy/desalination projects were identified: Delbuoy, the oscillating water column in Vizhinjam, CETO Freshwater, SAROS and Odyssee. It is concluded that wave power and desalination can be combined in a sustainable and autonomous system, generating freshwater from the ocean waves. However, questions regarding cost of produced water, variations in power production due to intermittency and environmental effects still remain.

  • Olofsson, Rikard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Supersymmetric Quantum Mechanics and the Gauss-Bonnet Theorem2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    We introduce the formalism of supersymmetric quantum mechanics, including super-symmetry charges,Z2-graded Hilbert spaces, the chirality operator and the Wittenindex. We show that there is a one to one correspondence of fermions and bosons forenergies different than zero, which implies that the Witten index measures the dif-ference of fermions and bosons at the ground state. We argue that the Witten indexis the index of an elliptic operator. Quantization of the supersymmetric non-linearsigma model shows that the Witten index equals the Euler characteristic of the un-derlying Riemannian manifold over which the theory is defined. Finally, the pathintegral representation of the Witten index is applied to derive the Gauss-Bonnettheorem. Apart from this we introduce elementary mathematical background in thesubjects of topological invariance, Riemannian manifolds and index theory

  • Nittler, Josefine
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Hunting for Dark Stars with the James Webb Space Telescope2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The first stars in the Universe are thought to have formed in high dark matter density minihalos about 200 million years after the Big Bang. If these stars were able to contract dark matter into their stellar core while forming, some of them might have turned into dark stars (DSs) powered by the heat from dark matter annihilation. The possibilities for detection of DSs with the upcoming James Webb Space Telescope (JWST), scheduled for launch in 2021, is investigated in this work. With DS models generated in Spolyar et al. (2009) and atmosphere spectra from Gustafsson et al. (2008), spectral analysis has been carried out in MATLAB to find the unique colors of DSs compared to galaxies generated in Zackrisson et al. (2017) at z ≈ 7 − 11. It was found that lower temperature DSs (Teff ≤ 7800K) are distinguishable from galaxies and that they would be bright enough to be detected with the JWST provided a magnification factor of µ ≈ 160−1000 with the use of gravitational lensing. More recent DS models reveal that the DS of temperature Teff = 7800K is detectable even without the use of gravitational lensing. However, the probability of finding one today is really small due to DSs’ presumably short lifetime. The results of this work are hoped to give a better understanding of the properties of DSs and to increase the probability of finding one in the large imaging survey carried out by the JWST.

  • Benedict, Christian
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Grillo, Claudia A.
    Univ South Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA..
    Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review2018In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 12, article id 215Article, review/survey (Refereed)
    Abstract [en]

    Research in animals and humans has shown that type 2 diabetes and its prodromal state, insulin resistance, promote major pathological hallmarks of Alzheimer's disease (AD), such as the formation of amyloid plaques and neurofibrillary tangles (NFT). Worrisomely, dysregulated amyloid beta (A beta) metabolism has also been shown to promote central nervous system insulin resistance; although the role of tau metabolism remains controversial. Collectively, as proposed in this review, these findings suggest the existence of a mechanistic interplay between AD pathogenesis and disrupted insulin signaling. They also provide strong support for the hypothesis that pharmacologically restoring brain insulin signaling could represent a promising strategy to curb the development and progression of AD. In this context, great hopes have been attached to the use of intranasal insulin. This drug delivery method increases cerebrospinal fluid concentrations of insulin in the absence of peripheral side effects, such as hypoglycemia. With this in mind, the present review will also summarize current knowledge on the efficacy of intranasal insulin to mitigate major pathological symptoms of AD, i.e., cognitive impairment and deregulation of A beta and tau metabolism.

  • Sjöholm, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy.
    Axelfunktion och omfattning av fysioterapeutisk behandling hos patienter med laterala nyckelbensfrakturer-en uppföljning 2–3år efter skadetillfället2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • Malmborn, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy.
    Westerberg, Erica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy.
    Kan en ökning av fysisk akivitet lindra depressiva symptom hos personer med övervikt och Obstruktiv sömnapné2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Obstructive sleep apnea (OSA) is obstruction of airflow during sleep leading to respiratory arrest. OSA is most common with obesity and among men. Individuals with OSA have a higher depression rate than the rest of the population. Physical activity (PA) has proven to be an effective treatment for depression.

    Aim: To investigate whether change in PA correlates with change in self-assessed depressive symptoms and if there are differences regarding gender or intensity levels.

    Method: A retrospective, descriptive, correlative and comparative study. Data was obtained from a previous study. PA and self-assessed depressive symptoms were measured with SenseWear Pro3 Armband and MADRS-S at baseline and at 6 months follow-up.

    Results: There was a correlation between an increase of PA and a decrease of MADRS-S score, r = -0.27, p = 0.04. The correlation for men was stronger r = -0.35 (p = 0.02). Women had a correlation between an increase in PA and an increase of MADRS-S score, r = 0.7 not statistically significant, p = 0.16. There was no difference in MADRS-S score between the groups performing PA at moderate intensity 5 (5.5) median (interquartile), respectively high intensity 4.5 (9.25), p=0.68

    Conclusion: The results showed a correlation between an increase in PA and a reduction of MADRS-S score. Regarding differences between genders or intensity levels the low number of women and physically active at high intensity meant no conclusions could be drawn.

  • Johansson, Carl Gustav
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Krisen under ytan: En kvantitativ undersökning om svensk medias aktiva rapportering under den påstådda ubåtskränkningen 20142018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    En kvantitativ undersökning om svensk medias aktiva rapportering under den påstådda ubåtskränkningen 2014 samt dess effekter.  

  • Public defence: 2018-09-08 09:00 Room 22-0008, Uppsala
    Basirat, Ali
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Principal Word Vectors2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Word embedding is a technique for associating the words of a language with real-valued vectors, enabling us to use algebraic methods to reason about their semantic and grammatical properties. This thesis introduces a word embedding method called principal word embedding, which makes use of principal component analysis (PCA) to train a set of word embeddings for words of a language. The principal word embedding method involves performing a PCA on a data matrix whose elements are the frequency of seeing words in different contexts. We address two challenges that arise in the application of PCA to create word embeddings. The first challenge is related to the size of the data matrix on which PCA is performed and affects the efficiency of the word embedding method. The data matrix is usually a large matrix that requires a very large amount of memory and CPU time to be processed. The second challenge is related to the distribution of word frequencies in the data matrix and affects the quality of the word embeddings. We provide an extensive study of the distribution of the elements of the data matrix and show that it is unsuitable for PCA in its unmodified form.

    We overcome the two challenges in principal word embedding by using a generalized PCA method. The problem with the size of the data matrix is mitigated by a randomized singular value decomposition (SVD) procedure, which improves the performance of PCA on the data matrix. The data distribution is reshaped by an adaptive transformation function, which makes it more suitable for PCA. These techniques, together with a weighting mechanism that generalizes many different weighting and transformation approaches used in literature, enable the principal word embedding to train high quality word embeddings in an efficient way.

    We also provide a study on how principal word embedding is connected to other word embedding methods. We compare it to a number of word embedding methods and study how the two challenges in principal word embedding are addressed in those methods. We show that the other word embedding methods are closely related to principal word embedding and, in many instances, they can be seen as special cases of it.

    The principal word embeddings are evaluated in both intrinsic and extrinsic ways. The intrinsic evaluations are directed towards the study of the distribution of word vectors. The extrinsic evaluations measure the contribution of principal word embeddings to some standard NLP tasks. The experimental results confirm that the newly proposed features of principal word embedding (i.e., the randomized SVD algorithm, the adaptive transformation function, and the weighting mechanism) are beneficial to the method and lead to significant improvements in the results. A comparison between principal word embedding and other popular word embedding methods shows that, in many instances, the proposed method is able to generate word embeddings that are better than or as good as other word embeddings while being faster than several popular word embedding methods.

  • Idevall Hagren, Karin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Aktör-nätverksteori och kritiska textanalyser: En diskussion om teori, metod och tillämpning2018In: Kritiska text- och diskursstudier / [ed] Wojahn, Daniel, Seiler Brylla, Charlotta & Westberg, Gustav, Huddinge: Södertörns högskola, 2018, p. 81-100Chapter in book (Refereed)
    Abstract [en]

    Actor-network theory (ANT) offers an approach to study how social phenomena and relations are developed and come to matter. ANT objects to using theory as an explanatory framework, within which empirics is added and shaped. ANT claims that theoretical presumptions should not be the starting point for critic, but rather that critique is an effect of close deployment of empirical data. This article aims to read ANT from a critical linguistics’ perspective in order to discuss how ANT can bring new perspectives on the social to linguistics, and offer concepts and tools for critical text analysis. The article introduces ANT’s ontology and epistemology as well as the theoretical perspectives derived from them. Furthermore, the article deals with ANT as a critical approach. Two analytical studies of language and racism are introduced to illustrate how linguists can benefit from using ANT, including concepts like black box, punctualizationand translation.

  • Holdar, Annika
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Håkansson, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Konsten att provocera med humor och kaxighet: En kvalitativ studie om attityder gentemot Oatlys provokativa reklam2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Positiva attityder gentemot varumärket är viktigt för företag. Om sambandet mellan attityden gentemot varumärket och attityden gentemot reklam är starkt tyder det på att företagets reklam är viktig för varumärket. Oatly har en provokativ reklamstrategi som väckt stor uppmärksamhet. Intressant är om denna provokativa marknadsföring leder till positiva attityder trots att det kan tänkas riskera att påverka attityderna negativt.

    Syftet med studien är att skapa förståelse för vilka attityder provokativ reklam genererar samt ge företag förståelse för hur provokativ reklam påverkar attityden gentemot varumärket. För att uppfylla syftet har tre fokusgrupper hållits där respondenternas känslor, uppfattningar och erfarenheter gällande Oatlys reklam har diskuterats. Resultatet av studien visar att Oatlys reklam upplevs provokativ eftersom den utmanar normer och inte främst framhäver varumärket. Trots att reklamen upplevs provokativ tycks attityderna vara positiva då reklamen är humoristisk och uppvisar ansvarstagande. Attityden gentemot reklamen speglar i stor utsträckning attityden gentemot varumärket.

  • Kubin, Markus
    et al.
    Institute for Methods and Instrumentation for Synchrotron Radiation Research, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany.
    Kern, Jan
    Lawrence Berkeley National Laboratory, Berkeley, USA.
    Guo, Meiyuan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Källman, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Mitzner, Rolf
    Institute for Methods and Instrumentation for Synchrotron Radiation Research, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany.
    Yachandra, Vittal K.
    Lawrence Berkeley National Laboratory, Berkeley, USA.
    Lundberg, Marcus
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Yano, Junko
    Lawrence Berkeley National Laboratory, Berkeley, USA.
    Wernet, Philippe
    Institute for Methods and Instrumentation for Synchrotron Radiation Research, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany.
    X-ray-induced sample damage at the Mn L-edge: a case study for soft X-ray spectroscopy of transition metal complexes in solution2018In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 20, no 24, p. 16817-16827Article in journal (Refereed)
    Abstract [en]

    X-ray induced sample damage can impede electronic and structural investigations of radiation-sensitive samples studied with X-rays. Here we quantify dose-dependent sample damage to the prototypical Mn-III(acac)(3) complex in solution and at room temperature for the soft X-ray range, using X-ray absorption spectroscopy at the Mn L-edge. We observe the appearance of a reduced Mn-II species as the X-ray dose is increased. We find a half-damage dose of 1.6 MGy and quantify a spectroscopically tolerable dose on the order of 0.3 MGy (1 Gy = 1 J kg(-1)), where 90% of Mn-III(acac)(3) are intact. Our dose-limit is around one order of magnitude lower than the Henderson limit (half-damage dose of 20 MGy) which is commonly employed for protein crystallography with hard X-rays. It is comparable, however, to the dose-limits obtained for collecting un-damaged Mn K-edge spectra of the photosystem II protein, using hard X-rays. The dose-dependent reduction of Mn-III observed here for solution samples occurs at a dose limit that is two to four orders of magnitude smaller than the dose limits previously reported for soft X-ray spectroscopy of iron samples in the solid phase. We compare our measured to calculated spectra from ab initio restricted active space (RAS) theory and discuss possible mechanisms for the observed dose-dependent damage of Mn-III(acac)(3) in solution. On the basis of our results, we assess the influence of sample damage in other experimental studies with soft X-rays from storage-ring synchrotron radiation sources and X-ray free-electron lasers.

  • Huang, Hongyun
    et al.
    Gen Hosp Armed Police Forces, Inst Neurorestoratol, Beijing 100039, Peoples R China..
    Young, Wise
    Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, Piscataway, NJ USA..
    Chen, Lin
    Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Beijing, Peoples R China..
    Feng, Shiqing
    Tianjin Med Univ, Dept Orthopaed, Gen Hosp, Tianjin, Peoples R China..
    Al Zoubi, Ziad M.
    Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan..
    Sharma, Hari Shanker
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Saberi, Hooshang
    Univ Tehran Med Sci, Dept Neurosurg, Brain & Spinal Injury Res Ctr, Tehran, Iran..
    Moviglia, Gustavo A.
    Maimonides Univ, Ctr Res & Engn Tissues & Cellular Therapy, Buenos Aires, DF, Argentina..
    He, Xijing
    Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China..
    Muresanu, Dafin F.
    Univ Med & Pharm, Dept Neurosci Iuliu Hatieganu, Cluj Napoca, Romania..
    Sharma, Alok
    LTMG Hosp, LTM Med Coll, Dept Neurosurg, Bombay, Maharashtra, India..
    Otom, Ali
    King Hussein Med Ctr RJRC Amman, Royal Rehabil Ctr, Amman, Jordan..
    Andrews, Russell J.
    NASA, Nanotechnol & Smart Syst, Ames Res Ctr, Silicon Valley, CA USA..
    Al-Zoubi, Adeeb
    Univ Illinois, Coll Med Peoria, Peoria, IL USA..
    Bryukhovetskiy, Andrey S.
    NeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia..
    Chernykh, Elena R.
    Inst Fundamental & Clin Immunol, Lab Cellular Immunotherapy, Novosibirsk, Russia..
    Domanska-Janik, Krystyna
    Mossakowski Med Res Ctr, Stem Cell Bioengn Unit, Warsaw, Poland..
    Jafar, Emad
    Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan..
    Johnson, W. Eustace
    Univ Chester, Fac Med Dent & Life Sci, Stem Cells & Regenerat Biol, Chester, Cheshire, England..
    Li, Ying
    UCL Inst Neurol, Dept Brain Repair & Rehabil, Spinal Repair Unit, London, England..
    Li, Daqing
    UCL Inst Neurol, Dept Brain Repair & Rehabil, Spinal Repair Unit, London, England..
    Luan, Zuo
    Navy Gen Hosp PLA, Dept Pediat, Beijing, Peoples R China..
    Mao, Gengsheng
    Gen Hosp Armed Police Forces, Inst Neurorestoratol, Beijing 100039, Peoples R China..
    Shetty, Ashok K.
    Texas A&M Hlth Sci Ctr, Coll Med, Inst Regenerat Med, Dept Mol & Cellular Med, College Stn, TX USA..
    Siniscalco, Dario
    Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy..
    Skaper, Stephen
    Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, Italy..
    Sun, Tiansheng
    PLA Army Gen Hosp, Dept Orthoped, Beijing, Peoples R China..
    Wang, Yunliang
    148th Hosp, Dept Neurol, Zibo, Shandong, Peoples R China..
    Wiklund, Lars
    Umea Univ, Dept Pharmacol & Clin Neurosci, Unit Neurol, Umea, Sweden..
    Xue, Qun
    Soochow Univ, Dept Neurol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China..
    You, Si-Wei
    Fourth Mil Med Univ, Xijing Hosp, Dept Ophthalmol, Xian, Shaanxi, Peoples R China..
    Zheng, Zuncheng
    Cent Hosp Taian, Dept Rehabil Med, Tai An, Shandong, Peoples R China..
    Dimitrijevic, Milan R.
    Baylor Coll Med, Houston, TX 77030 USA..
    El Masri, W. S.
    Robert Jones & Agnes Hunt Orthopaed Hosp, Spinal Injuries Unit, Oswestry, Shrops, England..
    Sanberg, Paul R.
    Univ S Florida, Morsani Coll Med, Ctr Excellence Aging Brain Repair, Tampa, FL USA..
    Xu, Qunyuan
    Capital Med Univ, Inst Neurosci, Beijing, Peoples R China..
    Luan, Guoming
    Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing, Peoples R China..
    Chopp, Michael
    Henry Ford Hlth Syst, Henry Ford Hosp, Neurol Res, Detroit, MI USA..
    Cho, Kyoung-Suok
    Catholic Univ Korea, Uijongbu St Marys Hosp, Coll Med, Dept Neurosurg, Uijongbu, South Korea..
    Zhou, Xin-Fu
    Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Div Hlth Sci, Adelaide, SA, Australia..
    Wu, Ping
    Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA..
    Liu, Kai
    Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China..
    Mobasheri, Hamid
    Univ Tehran, Inst Biochem & Biophys, Res Ctr, Tehran, Iran..
    Ohtori, Seiji
    Chiba Univ, Grad Sch Med, Dept Orthoped Surg, Chiba, Japan..
    Tanaka, Hiroyuki
    Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, Osaka, Japan..
    Han, Fabin
    Liaocheng Univ, Ctr Stem Cells & Regenerat Med, Liaocheng Peoples Hosp, Liaocheng, Shandong, Peoples R China..
    Feng, Yaping
    Kunming Gen Hosp Chengdu Mil Command Chinese PLA, Dept Neurosurg, Kunming, Yunnan, Peoples R China..
    Zhang, Shaocheng
    Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai, Peoples R China..
    Lu, Yingjie
    Chengde Dadu Hosp, Dept Neurosurg, Weichang, Hebei, Peoples R China..
    Zhang, Zhicheng
    PLA Army Gen Hosp, Dept Orthoped, Beijing, Peoples R China..
    Rao, Yaojian
    Luoyang Orthoped Hosp Henan Prov, Dept Neurosurg, Luoyang, Henan, Peoples R China..
    Tang, Zhouping
    Tongji Hosp, Tongji Med Coll HUST, Dept Neurol, Wuhan, Hubei, Peoples R China..
    Xi, Haitao
    Capital Med Univ, Dept Neurol, Beijing Rehabil Hosp, Beijing, Peoples R China..
    Wu, Liang
    Beijing Xiaotangshan Rehabil Hosp, Ctr Rehabil, Beijing, Peoples R China..
    Shen, Shunji
    Weihai Municipal Hosp, Dept Rehabil, Weihai, Shandong, Peoples R China..
    Xue, Mengzhou
    Zhengzhou Univ, Dept Neurorehabil, Affiliated Hosp 2, Zhengzhou, Henan, Peoples R China..
    Xiang, Guanghong
    Brain Hosp Hunan Prov, Changsha, Hunan, Peoples R China..
    Guo, Xiaoling
    PLA Army 266 Hosp, Dept Neurol, Chengde, Hebei, Peoples R China..
    Yang, Xiaofeng
    Zhejiang Univ, Dept Neurosurg, Coll Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China..
    Hao, Yujun
    Xinjiang Med Univ, Dept Neurosurg, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China..
    Hu, Yong
    Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China..
    Li, Jinfeng
    Umea Univ, Dept Pharmacol & Clin Neurosci, Unit Neurol, Umea, Sweden..
    Ao, Qiang
    China Med Univ, Dept Tissue Engn, Shenyang, Liaoning, Peoples R China..
    Wang, Bin
    Guangzhou Med Univ, Dept Traumatol, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China..
    Zhang, Zhiwen
    Chinese Peoples Liberat Army Gen Hosp, Dept Neurosurg, Affiliated Hosp 1, Beijing, Peoples R China..
    Lu, Ming
    Hunan Normal Univ, Dept Neurosurg, Affiliated Hosp 2, Hosp PLA 163, Changsha, Hunan, Peoples R China..
    Li, Tong
    Xinxiang Med Univ, Dept Neurol, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China..
    Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)2018In: Cell Transplantation, ISSN 0963-6897, E-ISSN 1555-3892, Vol. 27, no 2, p. 310-324Article, review/survey (Refereed)
    Abstract [en]

    Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

  • Esmieu, Charlène
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Raleiras, Patricia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Berggren, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    From protein engineering to artificial enzymes - biological and biomimetic approaches towards sustainable hydrogen production2018In: SUSTAINABLE ENERGY & FUELS, ISSN 2398-4902, Vol. 2, no 4, p. 724-750Article, review/survey (Refereed)
    Abstract [en]

    Hydrogen gas is used extensively in industry today and is often put forward as a suitable energy carrier due its high energy density. Currently, the main source of molecular hydrogen is fossil fuels via steam reforming. Consequently, novel production methods are required to improve the sustainability of hydrogen gas for industrial processes, as well as paving the way for its implementation as a future solar fuel. Nature has already developed an elaborate hydrogen economy, where the production and consumption of hydrogen gas is catalysed by hydrogenase enzymes. In this review we summarize efforts on engineering and optimizing these enzymes for biological hydrogen gas production, with an emphasis on their inorganic cofactors. Moreover, we will describe how our understanding of these enzymes has been applied for the preparation of bio-inspired/-mimetic systems for efficient and sustainable hydrogen production.

  • Fridén Syrjäpalo, Linda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Barns användande av platser i en mobil förskola2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Den mobila förskolan introducerades 2006, verksamheterna består av bussar som reser med barnen till olika platser. Införandet av de mobila förskoleverksamheterna var en lösning på akut brist på förskoleplatser och ett sätt att öka tillgång på utomhusmiljöer. Den första forskningen kring mobila förskolor bedrivs för närvarande på Institutionen för pedagogik, didaktik och utbildningsstudiet vid Uppsala universitet. Inom ramen för pågående forskningsprojekt är denna studies syfte att undersöka barns användande av och deltagande i de platser de besöker i en mobil förskola samt hur användande och deltagandet varierar i relation till plats. Frågeställningarna utgår från vilka ramar och förhållningsätt som presenteras av pedagogerna i relation till platsen och hur dessa hanteras av barnen. Vidare studeras hur barnen använder platsens fysiska egenskaper och materialiteter samt hur barnen använder olika platser för social interaktion i sina kamratkulturer.

    För att finna svar på frågeställningarna har videoupptagningar från en mobil förskoleverksamhet analyserats djupgående. Resultaten visar att barns användning av plats varierar utifrån de regler och förhållningssätt som pedagogerna presenterar i relation till platsen samt utifrån platsens fysiska förutsättningar. Barnen använder även platserna i sin sociala interaktion i kamratkulturer på olika sätt. På de platser barnen känner till sedan tidigare eller av andra anledningar har lyckats ta platsen i besittning via sina praktiker uppstår i högre grad social interaktion i kamratkulturer i form av olika sorters lek. 

    Studien är sprungen ur, och resultaten knyts samman med, ett intresse för en utökad samhällelig diskussion kring barns vardagliga praktiker sett ur ett medborgarskapsperspektiv samt barns medskapande av rumsligheter.

  • Laine, Merit
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Drømmebilleder. Carl Gustaf Pilos portrætkunst2018In: Konsthistorisk Tidskrift, ISSN 0023-3609, E-ISSN 1651-2294, Vol. 87, no 2, p. 115-118Article, book review (Other academic)
  • Didriksson, Nina
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Standardiserade arbetssätt: Barriäridentifiering och framläggning av riktlinjer för återimplementering av 5S2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The study has the intention to identify factors that prevent Organization X from succeeding with 5S as well as establish guidelines for reimplementation of the working method. Collected materials, through qualitative methods within phenomenological research framework, demonstrate that Organization X used to have good level of 5S in the organization. Maintaining this level has how ever been neglected during recent years. Current work in 5S is inadequate and several employees have requested structure and orderliness at the work place. Analyzation of differences between past and present work of 5S as well as analysing the difference between the employees’ expectations and Organization X promises of 5S in the organization and barriers affecting the accomplishment of 5S were identified. The identified barriers are: lack of top management commitment and requirement, lack of goals, vision and strategy, lack of education and training, inadequate leadership, resource shortages for improvement work, lack of follow-up and revision, unclear ownership responsibility and role allocation as well as lack of improvement process. A performed cultural analysis shows a rational organizational culture in Organization X which strives for stability and rapid short term changes. The organizational culture demonstrates a consonance with the current 5S-work, which may mean a resistance for change. An important activity to focus on in future reimplementation of 5S is to identify norms, values and incentive which have ability to affect drive forces to foster change. Organization X should focus on educating the top managers and the employees in 5S as well as initiating and follow up the implementation. The last implementation of 5S was successful. Based on the result of the previous implementation, Organization X could use previous strategy for reimplementation based on organizational experience. The chosen strategy for reimplementation of 5S should be adapted to Organization X words of value and business. Follow-ups and revisions as well as constructing an improvement process are important activities for 5S anchoring in the organization. The activities contribute to the cultural change 5S requires for successful reimplementation.

  • Holmquist, Jenny
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Byggcykel eller cykeltur?: En studie av byggcykelteorins tillämpbarhet på 1900-talets Sverige2018Student paper second term, 5 credits / 7,5 HE creditsStudent thesis
    Abstract [sv]

    I denna b-uppsats testas Lennart Schöns byggcykelteori genom att löneinkomster för arbetare inom byggnadsindustrin jämförs med träindustriarbetares och järn- stål- och kopparverksarbetares löneinkomster. Antagandet för uppsatsen är att om byggcykelteorin stämmer så kommer den reala löneutvecklingen följa ett cykliskt mönster som sträcker sig över en 20-årsperiod. Det kommer vidare att gå att urskilja ett samband mellan löneinkomster för byggnadsarbetare och träindustriarbetare respektive järn- stål- och kopparverksarbetare. Jämförelsen görs över åren 1913-1948 och all inkomstdata som används är hämtad från Historiska Lönedatabasen HILD, och åren har valts ut eftersom det för dessa år finns uppgifter om årsinkomst för samtliga kategorier. Jämförelsen görs både i fasta och rörliga priser.

     

    I undersökningen kommer jag fram till att löneutvecklingen för de olika yrkesgrupperna verkar följas åt relativt väl. Däremot går det inte att urskilja något cykliskt mönster av den typ som Lennart Schön själv beskriver. Däremot finns ett visst cykliskt mönster som inte följer det förutbestämda tidsintervallet. Dessa resultat ger inget direkt stöd till Schöns byggcykelteori, men uppsatsens undersökning är samtidigt för liten för att den skall kunna ligga till grund för att teorin förkastas helt. Slutsatsen i uppsatsen blir därför att det krävs vidare forskning på olika aspekter av ekonomin för att kunna avgöra huruvida byggcykelteorin bör förkastas eller ej.

  • Berg, Noora
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health. National Institute for Health and Welfare, Helsinki, Finland.
    Kiviruusu, Olli
    National Insitute for Health and Welfare, Helsinki, Finland.
    Bean, Christopher
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    Huurre, Taina
    National Institute for Health and Welfare, Helsinki, Finland.
    Lintonen, Tomi
    Finnish Foundation for Alcohol studies, Helsinki, Finland.; University of Tampere, Tampere, Finland.
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    Social relationships in adolescence and heavy episodic drinking from youth to midlife in Finland and Sweden: examining the role of individual, contextual and temporal factors2018In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 18, article id 1000Article in journal (Refereed)
    Abstract [en]

    Background

    Applying the Process-Person-Context-Time (PPCT) model of the bioecological theory, this study considers whether proximal processes between the individual and the microsystem (social relationships within family, peer group and school) during adolescence are associated with heavy episodic drinking (HED), from youth to midlife, and whether the macro level context (country) plays a role in these associations.

    Methods

    Participants of two prospective cohort studies from Finland and Sweden, recruited in 1983/1981 at age 16 (n = 2194/1080), were followed-up until their forties using postal questionnaires. Logistic regression analysis was used to examine associations between social relationships at age 16 and HED (at least monthly intoxication or having six or more units of alcohol in one occasion) at ages 22/21, 32/30 and 42/43. Additive interactions between microsystem settings, as well as between settings and country, were also considered.

    Results

    Consistent with the PPCT model, we found individual, contextual and temporal aspects to be associated with drinking habits. Higher levels of poor family relationships were associated with an increased likelihood of HED (ages 22/21 and 32/30) in both Finnish women and men and Swedish men. Higher levels of peer contact were associated with an increased likelihood of HED in both Finnish women (ages 32 and 42) and men (ages 22 and 32), and Swedish men (age 21). In contrast with the other groups, poorer relationships with classmates were associated with an increased likelihood of HED (age 30) for Swedish women only. For women, the combined effect of having both daily peer contact and living in Finland for HED at age 42/43 was statistically distinguishable from a pure additive effect.

    Conclusions

    Micro and to a lesser extent macro level contexts are associated with heavy episodic drinking well into adulthood. The most relevant processes in the adolescent microsystem occur in family and peer settings. However, long-lasting protective or risk-raising effects between different settings and later HED were not found. Promoting good relationships across different contexts during adolescence may reduce the incidence of HED in adulthood.

  • Brydsten, Anna
    et al.
    Stockholm Univ, Dept Publ Hlth Sci, SE-10691 Stockholm, Sweden.
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    San Sebastian, Miguel
    Umea Univ, Dept Publ Hlth & Clin Med, Epidemiol & Global Hlth Unit, SE-90185 Umea, Sweden.
    Health inequalities between employed and unemployed in northern Sweden: a decomposition analysis of social determinants for mental health2018In: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 17, article id 59Article in journal (Refereed)
    Abstract [en]

    Background: Even though population health is strongly influenced by employment and working conditions, public health research has to a lesser extent explored the social determinants of health inequalities between people in different positions on the labour market, and whether these social determinants vary across the life course. This study analyses mental health inequalities between unemployed and employed in three age groups (youth, adulthood and mid-life), and identifies the extent to which social determinants explain the mental health gap between employed and unemployed in northern Sweden. Methods: The Health on Equal Terms survey of 2014 was used, with self-reported employment (unemployed or employed) as exposure and the General Health Questionnaire (GHQ-12) as mental health outcome. The social determinants of health inequalities were grouped into four dimensions: socioeconomic status, economic resources, social network and trust in institutional systems. The non-linear Oaxaca decomposition analysis was applied, stratified by gender and age groups. Results: Mental health inequality was found in all age groups among women and men (difference in GHQ varying between 0.12 and 0.20). The decomposition analysis showed that the social determinants included in the model accounted for 43-51% of the inequalities among youths, 42-98% of the inequalities among adults and 60-65% among middle-aged. The main contributing factors were shown to vary between age groups: cash margin (among youths and middle-aged men), financial strain (among adults and middle-aged women), income (among men in adulthood), along with trust in others (all age groups), practical support (young women) and social support (middle-aged men); stressing how the social determinants of health inequalities vary across the life course. Conclusions: The health gap between employed and unemployed was explained by the difference in access to economic and social resources, and to a smaller extent in the trust in the institutional systems. Findings from this study corroborate that much of the mental health inequality in the Swedish labour market is socially and politically produced and potentially avoidable. Greater attention from researchers, policy makers on unemployment and public health should be devoted to the social and economic deprivation of unemployment from a life course perspective to prevent mental health inequality.

  • Kehoe, Kaat
    et al.
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Noels, Heidi
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    Theelen, Wendy
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    De Hert, Emilie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Xu, Shenguan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Verrijken, An
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    Arnould, Thierry
    Univ Namur UNamur, Namur Res Inst Life Sci NARILIS, Lab Biochem & Cell Biol URBC, Namur, Belgium.
    Fransen, Erik
    Univ Antwerp, StatUa Ctr Stat, Antwerp, Belgium.
    Hermans, Nina
    Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal Nat, Antwerp, Belgium.
    Lambeir, Anne-Marie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Van Gaal, Luc
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    De Meester, Ingrid
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 5, article id e0197603Article in journal (Refereed)
    Abstract [en]

    Background Prolyl carboxypeptidase (PRCP) is involved in the regulation of body weight, likely by hydrolysing alpha-melanocyte-stimulating hormone and apelin in the hypothalamus and in the periphery. A link between PRCP protein concentrations in plasma and metabolic disorders has been reported. In this study, we investigated the distribution of circulating PRCP activity and assessed its relation with body weight and adipose tissue in obese patients and patients who significantly lost weight. Methods PRCP activity was measured using reversed-phase high-performance liquid chromatography in different isolated blood fractions and primary human cells to investigate the distribution of circulating PRCP. PRCP activity was measured in serum of individuals (n = 75) categorized based on their body mass index (BMI < 25.0; 25.0-29.9; 30.0-39.9; >= 40.0 kg/m(2)) and the diagnosis of metabolic syndrome. Differences in serum PRCP activity were determined before and six months after weight loss, either by diet (n = 45) or by bariatric surgery (n = 24). Potential correlations between serum PRCP activity and several metabolic and biochemical parameters were assessed. Additionally, plasma PRCP concentrations were quantified using a sensitive ELISA in the bariatric surgery group. Results White blood cells and plasma contributed the most to circulating PRCP activity. Serum PRCP activity in lean subjects was 0.83 +/- 0.04 U/L and increased significantly with a rising BMI (p<0.001) and decreased upon weight loss (diet, p<0.05; bariatric surgery, p<0.001). The serum PRCP activity alteration reflected body weight changes and was found to be positively correlated with several metabolic parameters, including: total, abdominal and visceral adipose tissue. Plasma PRCP concentration was found to be significantly correlated to serum PRCP activity (0.865; p<0.001). Additionally, a significant decrease (p<0.001) in plasma PRCP protein concentration (mean +/- SD) before (18.2 +/- 3.7 ng/mL) and 6 months after bariatric surgery (15.7 +/- 2.7 ng/mL) was found. Conclusion Our novel findings demonstrate that white blood cells and plasma contributed the most to circulating PRCP activity. Additionally, we have shown that there were significant correlations between serum PRCP activity and various metabolic parameters, and that plasma PRCP concentration was significantly correlated to serum PRCP activity. These novel findings on PRCP activity in serum support further investigation of its in vivo role and involvement in several metabolic diseases.

  • Adam, Jonathan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Street Music, City Rhythms: The urban soundscape as heard by street musicians2018Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    The soundscape plays a key, if often overlooked, role in the construction of public urban space. Street music – a conscious deliberate propagation of sound in public space – opens an entryway into comprehending the role of sound in the city, and what it reveals about the city’s inhabitants. Ethnographic fieldwork in Brussels and Stockholm focuses on street musicians of all kinds, exploring how their music is shaped by their personal motivations, how their practices negotiate meaning in sound and in space, and how their rhythms shape, and are shaped by, the city. These explorations give reason to question R. Murray Schafer’s philosophies on soundscape studies, particularly in the urban context. Drawing from Henri Lefebvre’s notions of the production of space, and rhythmanalysis as an analytical tool, the urban soundscape is understood as an ongoing negotiation of individual actions, where dynamics of power, identity, and ideology become audible. Street musicians and their sound cultures feature not just as a topic worthy of study, but also as a guide of how and why to listen to and analyze the rhythms of the city.

  • Eleholt, Jenny
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sjölund, Anna-Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Interaktionen mellan patient och sjuksköterska vid NIV: Betydelsen av att bygga broar2018Independent thesis Advanced level (degree of Master (One Year)), 40 credits / 60 HE creditsStudent thesis
    Abstract [en]

    Background: Non-invasive ventilation (NIV) is a treatment that with good result can treat respiratory failure, a common syndrome in ICU units. NIV decrease mortality, invasive ventilation, time spent in ICU and ventilator- associated pneumonia. The treatment is often being terminated early due to that the patient does not accept it.

    Aim: The aim of the study was to illustrate the experience of NIV used during acute respiratory failure and the interaction between patient and nurse to optimize the treatment.

    Method: The study is a literature review with a descriptive design based on qualitative studies.

    Results: The patient experience a feeling of being trapped behind the mask and put a great effort in acceptance of NIV and to regain control. The treatment is described as a necessary but uncomfortable path to survival. The interaction between patient and nurse is affected by the way the nurses meet the patients need of participation, information and control. 

    Conclusion: For the tolerans of the treatment the interaction between patient and nurse have a great importance. The role of the nurse is to support the patient through create understanding and make the patient participate. Trough that the patient can regain control and the treatment can be optimized. 

  • Julia, Olsson
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Frida, Engelmann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    En journalgranskning om risk för undernäring hos inneliggande patienter2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Malnutrition is defined by deficits in the energy- and nutrition levels. This state results in weight loss. One way to measure malnutrition is through a body-mass index (BMI). During illness, the body’s metabolism increases, which in return requires a greater intake of energy- and nutrition. At the same time, the state of the illness may make the food intake more difficult. Risk evaluation is an aid for nurses that should be performed with every patient. The nurse is required by law to discover malnutrition or risk of malnutrition at an early stage and put in relevant interventions to prevent deterioration of the patients’ physical health.

     

    Objective: The aim of the study was to highlight to what extent the nurses document risk evaluation for malnutrition and what interventions were used to prevent malnutrition during the hospital stay.

     

    Method: The study has a quantitative, prospective and descriptive design and was performed as a journal evaluation.

     

    Result: The results showed that 31% of the inpatients suffered of malnutrition or risk thereof. The three most common interventions against malnutrition were: nutritional dietary records, estimated energy requirements and daily weight. Risk evaluation was performed on 47% of all patients, which means that half of the studied patients receive no evaluation at all. Follow up of the interventions were not presented in any journal.

     

    Conclusion: Only 47% of all inpatients had a complete risk evaluation documented in their journal. Most of the interventions are standardized evaluations and do not in itself counteract malnutrition but need complementary interventions.

  • Rehnström, Isabelle
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Törner, Elias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Stress och överbelastning: Ett hot mot sjuksköterskor och omvårdnaden av patienter2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Stress is a part of nurses' everyday lives. Low stress levels are good, while high stress levels affect people negatively. As the workload on nurses can be overwhelming, stressful and heavy, there might be a risk that the patients’ safety can be jeopardised.

    Aim: To examine if the nurses’ experience of stress and a heavy workload in the nursing profession affects the care of the patient.

    Method: The study used a systematic review with 12 original articles. To find relevant articles the authors searched in the databases of Pubmed and Cinahl.

    Result: Four categories of nurses’ experiences of stress were identified: patient safety, burn out, working environment and workload and shift work. The result showed that stress had a negative impact on nursing. The stress arose because of assorted reasons, such as a heavy workload or poor working environment. The reason to this was to long work shifts and to many patients per nurse. Many nurses were dissatisfied with their work situation and many of them had thought about changing their jobs. The stress could also lead to exhaustion and burnout among the nurses. Therefore, the stress related to exhaustion, but also with the heavy workload and work environment.

    Conclusion: There were too high stress levels in healthcare, which thereby affected the nursing. The effect of a heavy workload on nurses is a major factor in stress affecting the healthcare. Further research could be used to optimize the healthcare.

  • Laurén, Ida
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lundin, Moa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Faktorer inom vården som har betydelse för det psykiska måendet hos syskon till cancersjuka barn - en litteraturöversikt2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: When a child in the family is treated for cancer, the invasive roles in the family changes and the focus is on the sick child. Siblings of children with cancer can experience feelings and thoughts that can be difficult to handle on their own. 

    Purpose: The purpose is to compile knowledge about which supportive and other factors in health care that affects the siblings psychological health after a brother or sisters cancer treatment. 

    Method: Literature review based on 10 original articles. The research was applied to the database PubMed and the articles had qualitative and quantitative methods. 

    Results: The results of this literature review can be divided into two categories; information and emotions, and seven subcategories; Cancer disease, involvement in the progression of the disease, before death, healthcare personnel, changes in the family, subjective experiences of having a sibling with cancer and lack of opportunity to talk about feelings and thoughts. The results show that the psychological health of siblings is adversely affected by inadequate information about cancer, disease progression and bodily changes before death. It also appears that the sibling's psychological health is adversely affected by lack of attention from parents and healthcare professionals. Factors that affects sibling's psychological health positively are the opportunity to express feelings and to have the feelings confirmed by parents or healthcare professionals. 

    Conclusion: This literature review shows that siblings to a brother or sister with cancer need to get information and talk about their feelings and thoughts. Lack of information and emotional support from parents and healthcare professionals can lead to a negative impact of the psychological health. As a nurse it's important to pay attention to the sibling´s needs for support to prevent psychological illness later in life.

  • Lorenzová, Karolína
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Borlind, Charlotte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Consumer Confusion and Attitudes: A Study of Eco-Labels2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Purpose: The purpose of this study was to explain whether the conceptualized model of consumer confusion regarding the multiple number of brands and products also applies to the increasing number of eco-labels. The study also examined how the attitudes were affected if confusion occurred amongst the consumers. More specifically, whether consumer confusion leads to negative attitudes.

    Theoretical Framework: The conceptualized model of consumer confusion, including the three dimensions of ambiguity, information overload and similarity was used in this research.In addition, theories regarding attitudes and indicators that affect consumer’s attitudes werepresented and used for the analysis.

    Methodological Framework: This research took an explanatory and deductive approach. The research was carried out with a quantitative method including three hypotheses derived from the literature. Data was collected through a questionnaire that was spread online on social media. The gathered data was coded accordingly in order to get the results from the frequencies, descriptive statistics, correlation and the regression analysis.

    Empirical Results: It was discovered that the respondents were confused by eco-labels and eco-labelled products regarding all the three dimensions of the conceptualized model of consumer confusion. However, the fact that the attitudes towards eco-labels and eco-labelled products were very positive, led to a rejection of all the three hypotheses. Consequently, supportive questions from the questionnaire and the demographic details of the sample served as additional support to further discuss the results of the study.

    Conclusions: This study showed that the conceptualized model of consumer confusion also applies to eco-labels. However, the consumers still had positive attitudes towards eco-labels and eco-labelled products which could be seen as contradictory. Nevertheless, positive beliefs about eco-labels and its effects and demographic details were found to have an impact on the positive attitudes.

  • Pettersson, John H.-O.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway;Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Natl Vet Inst, Dept Microbiol, Uppsala, Sweden.
    Bohlin, Jon
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Dupont-Rouzeyrol, Myrielle
    Inst Pasteur Nouvelle Caledonie, Unite Rech Expertise Dengue & Autres Arboviroses, Noumea, New Caledonia.
    Brynildsrud, Ola B.
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Alfsnes, Kristian
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Cao-Lormeau, Van-Mai
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gaunt, Michael W.
    London Sch Hyg & Trop Med, London, England.
    Falconar, Andrew K.
    Univ Norte, Dept Med, Barranquilla, Colombia.
    De Lamballerie, Xavier
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France;Univ Mediterranee Infect, Inst Hosp, Publ Hosp Marseille, AP HM, Marseille, France.
    Eldholm, Vegard
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Musso, Didier
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gould, Ernest A.
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France.
    Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia2018In: EMERGING MICROBES & INFECTIONS, ISSN 2222-1751, Vol. 7, article id 79Article in journal (Refereed)
    Abstract [en]

    Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas. Our findings reveal new features of the evolution and dispersal of this intriguing virus and may benefit future disease control strategies.