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  • Gregorcic, Bor
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Physics Didactics.
    Haglund, Jesper
    Department of Engineering and Physics, Karlstad University.
    Conceptual Blending as an Interpretive Lens for Student Engagement with Technology: Exploring Celestial Motion on an Interactive Whiteboard2018In: Research in science education, ISSN 0157-244X, E-ISSN 1573-1898Article in journal (Refereed)
    Abstract [en]

    We present and analyze video data of upper secondary school students’ engagement with a computer-supported collaborative learning environment that enables them to explore astronomical phenomena (Keplerian motion). The students’ activities have an immersive and exploratory character, as students engage in open-ended inquiry and interact physically with the virtual environment displayed on an interactive whiteboard. The interplay of students’ playful exploration through physical engagement with the simulation environment, their attention to physics concepts and laws, and knowledge about the real planets orbiting the Sun presents an analytical challenge for the researcher and instructor encountering such complex learning environments. We argue that the framework of conceptual blending is particularly apt for dealing with the learning environment at hand, because it allows us to take into account the many diverse mental inputs that seem to shape the student activities described in the paper. We show how conceptual blending can be brought together with theoretical ideas concerned with embodied cognition and epistemology of physics, in order to provide researchers and instructors with a powerful lens for looking critically at immersive technology-supported learning environments.

  • Unsworth, Richard K. F.
    et al.
    McKenzie, Len J.
    Collier, Catherine J.
    Cullen-Unsworth, Leanne C.
    Duarte, Carlos M.
    Eklöf, Johan S.
    Jarvis, Jessie C.
    Jones, Benjamin L.
    Nordlund, Lina M.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development.
    Global challenges for seagrass conservation2018In: Ambio, ISSN 0044-7447, E-ISSN 1654-7209Article in journal (Refereed)
    Abstract [en]

    Seagrasses, flowering marine plants that form underwater meadows, play a significant global role in supporting food security, mitigating climate change and supporting biodiversity. Although progress is being made to conserve seagrass meadows in select areas, most meadows remain under significant pressure resulting in a decline in meadow condition and loss of function. Effective management strategies need to be implemented to reverse seagrass loss and enhance their fundamental role in coastal ocean habitats. Here we propose that seagrass meadows globally face a series of significant common challenges that must be addressed from a multifaceted and interdisciplinary perspective in order to achieve global conservation of seagrass meadows. The six main global challenges to seagrass conservation are (1) a lack of awareness of what seagrasses are and a limited societal recognition of the importance of seagrasses in coastal systems; (2) the status of many seagrass meadows are unknown, and up-to-date information on status and condition is essential; (3) understanding threatening activities at local scales is required to target management actions accordingly; (4) expanding our understanding of interactions between the socio-economic and ecological elements of seagrass systems is essential to balance the needs of people and the planet; (5) seagrass research should be expanded to generate scientific inquiries that support conservation actions; (6) increased understanding of the linkages between seagrass and climate change is required to adapt conservation accordingly. We also explicitly outline a series of proposed policy actions that will enable the scientific and conservation community to rise to these challenges. We urge the seagrass conservation community to engage stakeholders from local resource users to international policy-makers to address the challenges outlined here, in order to secure the future of the world’s seagrass ecosystems and maintain the vital services which they supply.

  • Svensson, Josefin
    Uppsala University, University Administration, Communications Division.
    Universen 4:2018: En tidning för Uppsala universitets medarbetare2018Collection (editor) (Other (popular science, discussion, etc.))
    Abstract [sv]

    Innehåll i Universen nr 4:2018

    Sid 2: Ledare

    Sid 3: Emma Tysk är årets Uppsalastudent

    Sid 4: Klimatledarskap i praktiken

    Sid 5: Koldioxidbudgetar ska hjälpa kommunerna att nå klimatmålen

    Sid 6: "Det här är det roligaste jobbet"

    Sid 7: Sista Tea-dagen?

    Sid 8: Utmaning att komma från studieovan miljö

    Sid 9: Samarbete för bättre digitala resurser

    Sid 10: Farmaceutiska fakulteten 50 år: "Vi växer hela tiden"

    Sid 12: Flyktingkrisen i fokus för europeiskt forskningsprojekt

    Sid 13: "Som immunolog är det lätt att vara entusiastisk"

    Sid 14: Gifta - och forskarkollegor

    Sid 17: Läsning signerad Uppsala universitet

    Sid 19: Årets topp 10

    Sid 20: Profilen - Stefan Sjöström

  • Wang, Sheng
    et al.
    China Agr Univ, Coll Biol Sci, Beijing, Peoples R China;Natl Inst Biol Sci, Beijing, Peoples R China;Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Mandell, Jeffrey D.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Kumar, Yogesh
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Sun, Nawei
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Morris, Montana T.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Arbelaez, Juan
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Nasello, Cara
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Dong, Shan
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.
    Duhn, Clif
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Zhao, Xin
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA;Shanghai Jiatong Univ, Sch Med, Xinhua Hosp, Dept Tradit Chinese Med, Shanghai, Peoples R China.
    Yang, Zhiyu
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Padmanabhuni, Shanmukha S.
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Yu, Dongmei
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    King, Robert A.
    Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA;Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
    Dietrich, Andrea
    Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, Groningen, Netherlands.
    Khalifa, Najah
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Dahl, Niklas
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Huang, Alden Y.
    Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
    Neale, Benjamin M.
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    Coppola, Giovanni
    Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
    Mathews, Carol A.
    Univ Florida, Dept Psychiat, Genet Inst, Gainesville, FL 32611 USA.
    Scharf, Jeremiah M.
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    Fernandez, Thomas V.
    Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA;Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
    Buxbaum, Joseph D.
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    De Rubeis, Silvia
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    Grice, Dorothy E.
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    Xing, Jinchuan
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Heiman, Gary A.
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Tischfield, Jay A.
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Paschou, Peristera
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Willsey, A. Jeremy
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA;Univ Calif San Francisco, QBI, San Francisco, CA 94143 USA.
    State, Matthew W.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, QBI, San Francisco, CA 94143 USA.
    De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis2018In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 24, no 13, p. 3441-+Article in journal (Refereed)
    Abstract [en]

    We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novo damaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novo copy number variants in TD. Finally, we identify significant overlap of de novo sequence variants between TD and obsessive-compulsive disorder and de novo copy number variants between TD and autism spectrum disorder, consistent with shared genetic risk.

  • Menniti, Matteo
    Tailoring the magnetic anisotropy in amorphous FeZr-based thin films on flexible and solid substrates2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis the magnetic properties of novel amorphous magnetic materials grown on a flexible substrate of polyethylene naphthalate and a silicon wafer have been analyzed and characterized. The analyzed films are two films of amorphous Cobalt-Iron-Zirconium(Co36Fe53Zr11 & Co37Fe55Zr8) grown on the flexible substrate and two films of amorphous (Fe89Zr11) doped with boron (B). The B is implanted in a lattice of rings with inner diameter of 10 μm and outer diameter of 20 μm and with the distance between the center of the rings of either 50 μm or 25 μm. The composition in the doped region is Fe80Zr10B10.

    Various magneto-optical Kerr effect(MOKE) magnetometers are used to measure hysteresis loops of the samples and a superconducting quantum interference device (SQUID) is used to find the volume magnetization of the flexible samples. To measure the anisotropy in the flexible films a series of sample holders has been developed to measure various amount of stress using the same sample in magneto-optical magnetometers. The stress induced uniaxial anisotropy is found by measuring hysteresis loops of the flexible samples while bending them with different curvatures. The induced anisotropy is related to the magnetostriction and the magnetostriction constants is estimated for the two flexible samples by assuming values for Young’s modulus and Poisson’s ratio. The estimated values for the magnetostriction constant are found to vary with the amount of Zr and to be in the correct order of magnitude for magnetic films.

    The implanted B rings with the short distance of 25 μm between the center showed to have some interaction between the rings. This conclusion is drawn after analyzing first order reversal curves of the samples and looking at the domains under a MOKE-microscope. At very low temperatures the (unimplanted) FeZr matrix is ferromagnetic and seem to have an anti-ferromagnetic coupling with the B rings. At room temperature the rings are still ferromagnetic and they couple to each other.

  • Mason, David C.
    et al.
    Univ Reading, Dept Geog & Environm Sci, Reading, Berks, England.
    Dance, Sarah L.
    Univ Reading, Dept Meteorol, Reading, Berks, England;Univ Reading, Dept Math & Stat, Reading, Berks, England.
    Vetra-Carvalho, Sanita
    Univ Reading, Dept Meteorol, Reading, Berks, England.
    Cloke, Hannah L.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Univ Reading, Dept Geog & Environm Sci, Reading, Berks, England;Univ Reading, Dept Meteorol, Reading, Berks, England.
    Robust algorithm for detecting floodwater in urban areas using synthetic aperture radar images2018In: Journal of Applied Remote Sensing, ISSN 1931-3195, E-ISSN 1931-3195, Vol. 12, no 4, article id 045011Article in journal (Refereed)
    Abstract [en]

    Flooding is a major hazard in both rural and urban areas worldwide, but it is in urban areas that the impacts are most severe. High-resolution synthetic aperture radar (SAR) sensors are able to detect flood extents in urban areas during both day- and night-time. If obtained in near real time, these flood extents can be used for emergency flood relief management or as observations for assimilation into flood forecasting models. A method for detecting flooding in urban areas using near real-time SAR data is developed and extensively tested under a variety of scenarios involving different flood events and different images. The method uses an SAR simulator in conjunction with LiDAR data of the urban area to predict areas of radar shadow and layover in the image caused by buildings and taller vegetation. Of the urban water pixels visible to the SAR, the flood detection accuracy averaged over the test examples is 83%, with a false alarm rate of 9%. The results indicate that flooding can be detected in the urban area to reasonable accuracy but that this accuracy is limited partly by the SAR's poor visibility of the urban ground surface due to shadow and layover. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

  • Henriksson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    The acceleration of the Moon and the Universe - the Mass of the Graviton2017In: Advances in Astrophysics, ISSN 2415-6450, Vol. 2, no 3, p. 184-196Article in journal (Refereed)
    Abstract [en]

    To get accurate knowledge about the longitudinal motion of the Moon we must use the oldest preserved interpretable depictions and texts from the ancient cultures. Well documented total solar eclipses from Sumerian cylinder seals, Sumerian, Babylonian, Assyrian, Chinese, Hittite and Greek texts, and depictions on the Swedish rock-carvings from the Bronze Age, have been used in an analysis, performed by the author in 2011, to determine the lunar sidereal secular acceleration. It was based on 33 ancient total or almost total solar eclipses back to 3653 BC. In 2014 and 2016 the margins of error was determined. The new value for the lunar sidereal secular acceleration in longitude = -30.128±0.0035 arcseconds/(century)2 ("/cy2). The lunar secular acceleration, from the Lunar Laser Range (LLR) measurements, -25.856 ±0.003"/cy2, must be corrected for the relativistic effect, -3.604"/cy2, in the Earth-Moon inertial system, to get the lunar sidereal secular acceleration, –29.460 "/cy2, corrected for General Relativity. The difference between this value and the new calibration, -0.668±0.0046"/cy2, corresponds to the cosmological acceleration predicted by Dvali et al. in a Modified Theory of gravity. This value corresponds to a mass of the graviton = 1.306 ±0.009 x 10-56 grams.   If this theory is correct, there is no need for the enigmatic Dark Energy.

  • Phoosuwan, Nitikorn
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Eriksson, Leif
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Lundberg, Pranee C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Statistical Analyses Of The Thai Version Of The Edinburgh Postnatal Depression Scale Among Thai Women During The Antenatal Period In North-Eastern Thailand2017Conference paper (Refereed)
  • Rodin, Sergey
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden.
    Rebellato, Paola
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Lundin, Arne
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Zubarev, Roman A.
    Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden;IM Sechenov First Moscow State Med Univ, Dept Pharmacol & Technol Chem, Moscow, Russia.
    Isotopic resonance at 370 ppm deuterium negatively affects kinetics of luciferin oxidation by luciferase2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 16249Article in journal (Refereed)
    Abstract [en]

    Since 1930s, it has been known that some biochemical and biological processes exhibit abnormal kinetics at a deuterium concentration in the local environment of 250-600 ppm, which is 2-4 times higher that the normal concentration of 150 ppm D. We sought to test if the kinetics of firefly luciferase oxidizing luciferin, the reaction widely used as a read-out in various biochemical assays, is also affected by an elevated deuterium content. To this end, both luciferase and luciferin substrate solutions were prepared based on water with extra deuterium added to a concentration ranging from 150 ppm and up to 10,000 ppm (1%). Upon mixing the solutions, the luminescence intensity at different times was compared with that of the corresponding control solutions with 150 ppm D. A broad negative resonance was detected (p < 10(-6)), with a approximate to 20% drop in luminescence at 370 ppm D. Given that, on average, about half of hydrogen atoms in proteins are not exchangeable in solution, this value corresponds to approximate to 260 ppm of deuterium in all enzyme's hydrogens, in a very good agreement with the prediction of the Isotopic resonance hypothesis.

  • Karademir, Betul
    et al.
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey.
    Sari, Gulce
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey;Okan Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey.
    Jannuzzi, Ayse Tarbin
    Istanbul Univ, Fac Pharm, Dept Pharmaceut Toxicol, Istanbul, Turkey.
    Musunuri, Sravani
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Wicher, Grzegorz
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
    Grune, Tilman
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Mi, Jia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China.
    Hacioglu-Bay, Husniye
    Marmara Univ, Sch Med, Dept Anat, Istanbul, Turkey.
    Forsberg-Nilsson, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Jung, Tobias
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 16318Article in journal (Refereed)
    Abstract [en]

    The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical applications. However neuropathic side effects are dose limiting for BTZ as many other chemotherapeutic agents. Therefore second-generation proteasome inhibitors have been developed including carfilzomib (CFZ). Aim of the present work was investigating the mechanisms of peripheral neuropathy triggered by the proteasome inhibitor BTZ and comparing the pathways affected by BTZ and CFZ, respectively. Neural stem cells, isolated from the cortex of E14 mouse embryos, were treated with BTZ and CFZ and mass spectrometry was used to compare the global protein pool of treated cells. BTZ was shown to cause more severe cytoskeletal damage, which is crucial in neural cell integrity. Excessive protein carbonylation and actin filament destabilization were also detected following BTZ treatment that was lower following CFZ treatment. Our data on cytoskeletal proteins, chaperone system, and protein oxidation may explain the milder neurotoxic effects of CFZ in clinical applications.

  • Albaalbaky, Ahmed
    et al.
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Kvashnin, Yaroslav
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Patte, Renaud
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Fresard, Raymond
    Normandie Univ, CRISMAT, CNRS, UNICAEN,ENSICAEN, F-14050 Caen, France.
    Ledue, Denis
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Effects of Ga doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2: Ab initio and Monte Carlo approaches2018In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, no 17, article id 174403Article in journal (Refereed)
    Abstract [en]

    The effects of nonmagnetic impurity doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2 are investigated by means of density functional theory calculations and Monte Carlo simulations. Density functional theory calculations show that replacing up to 30% of Cr3+ ions by Ga3+ ones does not significantly affect the remaining Cr-Cr superexchange interactions. Monte Carlo simulations show that CuCr1-xGaxO2 preserves its magnetoelectric properties up to x similar or equal to 0.15 with a spiral ordering, while it becomes disordered at higher fractions. Antiferromagnetic transition shifts towards lower temperatures with increasing x and eventually disappears at x >= 0.2. Our simulations show that Ga3+ doping increases the Curie-Weiss temperature of CuCr1-xGaxO2, which agrees well with experimental observations. Moreover, our results show that the incommensurate ground-state configuration is destabilized by Ga3+ doping under zero applied field associated with an increase of frustration. Finally, coupling between noncollinear magnetic ordering and electric field is reported for x <= 0.15 through simulating P-E hysteresis loops, which leads to ferroelectricity in the extended inverse Dzyaloshinskii-Moriya model.

  • Gao, Tianle
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China.
    Ma, Haisha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
    Xu, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Bergman, Jessica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Larhammar, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Lagerström, Malin C.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
    The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch2018In: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 138, no 11, p. 2405-2411Article in journal (Refereed)
    Abstract [en]

    Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y-1 receptor system on scratch behavior in mice. We found that intrathecal administration of the Y-1 agonist [Leu(31), Pro(34)]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck compared with saline treatment, indicating that activation of the spinal NPY/Y-1 system dampens mechanical itch. However, intrathecal administration of LP-NPY also attenuated chemically induced scratching provoked by intradermal application of histamine or the mast cell degranulator 48/80 (histaminergic itch), and the latter effect could be reversed by administration of the Y-1 antagonist BIBO3304. Intrathecal application of the native nonselective agonist NPY also attenuated histamine or 48/80-induced scratching. Our analyses emphasize the importance of including additional quantitative parameters to characterize the full spectrum of itch behavior and show that the NPY/Y-1 system dampens both mechanically and chemically induced scratching and hence is shared by the two submodalities of itch.

  • Pincini, D.
    et al.
    UCL, London Ctr Nanotechnol, Gower St, London WC1E 6BT, England;UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England;Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Fabrizi, F.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Beutier, G.
    Univ Grenoble Alpes, CNRS, Grenoble INP, SIMaP, F-38000 Grenoble, France.
    Nisbet, G.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Elnaggar, H.
    Univ Utrecht, Debye Inst Nanomat Sci, Univ Weg 99, NL-3584 CG Utrecht, Netherlands.
    Dmitrienko, V. E.
    AV Shubnikov Inst Crystallog, FSRC Crystallog & Photon RAS, Moscow 119333, Russia.
    Katsnelson, M. , I
    Kvashnin, Yaroslav
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Lichtenstein, A. , I
    Mazurenko, V. V.
    Ural Fed Univ, Dept Theoret Phys & Appl Math, Mira Str 19, Ekaterinburg 620002, Russia.
    Ovchinnikova, E. N.
    Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119991, Russia.
    Dimitrova, O. , V
    Collins, S. P.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Role of the orbital moment in a series of isostructural weak ferromagnets2018In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, no 10, article id 104424Article in journal (Refereed)
    Abstract [en]

    The orbital contribution to the magnetic moment of the transition-metal ion in the isostructural weak ferromagnets ACO(3) (A = Mn,Co,Ni) and FeBO3 was investigated by a combination of first-principles calculations, nonresonant x-ray magnetic scattering, and x-ray magnetic circular dichroism. A nontrivial evolution of the orbital moment as a function of the 3d orbitals filling is revealed, with a particularly large value found in the Co member of the family. Here, the coupling between magnetic and lattice degrees of freedom produced by the spin-orbit interaction results in a large single-ion anisotropy and a peculiar magnetic-moment-induced electron cloud distortion, evidenced by the appearance of a subtle scattering amplitude at space-group-forbidden reflections and significant magnetostrictive effects. Our results, which complement a previous investigation on the sign of the Dzyaloshinskii-Moriya interaction across the series, highlight the importance of spin-orbit coupling in the physics of weak ferromagnets and prove the ability of modern first-principles calculations to predict the properties of materials where the Dzyaloshinskii-Moriya interaction is a fundamental ingredient of the magnetic Hamiltonian.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zur Nedden, M.
    Prompt and non-prompt J/psi and psi(2S) suppression at high transverse momentum in 5.02 TeV Pb+Pb collisions with the ATLAS experiment2018In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, no 9, article id 762Article in journal (Refereed)
    Abstract [en]

    A measurement of J/psi and psi(2S) production is presented. It is based on a data sample from Pb+Pb collisions at root s(NN) = 5.02 TeV and pp collisions at root s = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of 0.42 nb(-1) and 25 pb(-1) in Pb+Pb and pp, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for 9 < p(T)(mu mu) < 40 GeV in dimuon transverse momentum, and -2 < y(mu mu) < 2 in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt J/psi, increasing with event centrality. The suppression of prompt psi(2S) is observed to be stronger than that of J/psi, while the suppression of non-prompt psi(2S) is equal to that of the non-prompt J/psi within uncertainties, consistent with the expectation that both arise from b-quarks propagating through the medium. Despite prompt and non-prompt J/psi arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar.

  • Norström, Elin
    et al.
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden.
    Noren, Gabriel
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden;Univ Cologne, Inst Geol & Mineral, D-50923 Cologne, Germany.
    Smittenberg, Rienk H.
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden.
    Massuanganhe, Elidio A.
    Univ Eduardo Mondlane, Dept Geol, CP 257, Maputo, Mozambique.
    Ekblom, Anneli
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Leaf wax delta D inferring variable medieval hydroclimate and early initiation of Little Ice Age (LIA) dryness in southern Mozambique2018In: Global and Planetary Change, ISSN 0921-8181, E-ISSN 1872-6364, Vol. 170, p. 221-233Article in journal (Refereed)
    Abstract [en]

    A sediment sequence from a coastal, hydrologically isolated lake in southern Mozambique was analysed for leaf wax delta D, n-alkane abundance (ACL) and bulk organic geochemistry (delta C-13, TOC, %N), providing a record of past rainfall variability and savanna dynamics over the last 1500 years. The delta D-wax a rainfall reconstruction reveals a stable hydroclimate between 500-700 CE, while ACL and delta C-13 together with previous pollen data suggest savanna vegetation was characterized by a relatively dense woody cover. Highly variable hydroclimate conditions are inferred by delta D-wax between 800-1350 CE, with repeated centennial scale intervals of extreme dry and wet conditions overlapping the Medieval Climate Anomaly (MCA; 950-1250 CE). Savanna tree cover stayed relatively intact over this phase. After ca 1250 CE, a progressive change towards drier conditions was initiated, leading up to maximum aridity during the AD 1700s, a period associated with the Little Ice age (LIA; 1500-1850 CE). Tree cover was now replaced by a more grass-dominated savanna. The clear antiphase rainfall patterns between Nhaucati and equatorial East African proxy records gives support to the notion that Indian Ocean sea surface temperature (SST) gradients act as modulator of southern African climate on a multi-decadal time scale, possibly forced by long-term El Nino Southern Oscillation (ENSO) variability. We suggest that strong ENSO variability and greater occurrence of La Nina events triggered the generally wet and unstable MCA in southern Africa. From around 1250 CE, a shift towards a predominance of El Nino induced drier conditions in south-east Africa during the LIA. Our study of vegetation and hydroclimate proxies in parallel suggests that savanna tree and shrub cover was relatively resilient to the abrupt shifts in hydroclimate over the MCA, but more sensitive to the long-term progressive drying over the LIA.

  • Brändas, Erkki
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Hoffmann, Mark
    Preface2018In: International Journal of Quantum Chemistry, ISSN 0020-7608, E-ISSN 1097-461X, Vol. 118, no 1, p. 1-2, article id e25517Article in journal (Refereed)
    Abstract [en]

    This volume collects 11 selected papers from the scientific contributions presented at the Ninth Congress of the International Society for Theoretical Chemical Physics (ISTCP-IX), organized by the team led by Professor Mark Hoffmann at the University of North Dakota, Grand Forks, North Dakota, U.S.A., from July 17 to 22, 2016. The ISTCP-IX Congress in Grand Forks followed the format established at the eight previous meetings:

     

    ISTCP-I:               Professor Ramon Carbo-Dorca, Girona (Spain), June 28 - July 3, 1993

    ISTCP-II:             Professor Sean P. McGlynn, New Orleans (LA, USA), April 9 - 13, 1996

    ISTCP-III:            Professor Miguel Castro, Mexico City (DF, Mexico), November 8 - 13, 1999

    ISTCP-IV:            Professor Jean Maruani, Marly-le-Roi (Paris, France), July 9 - 16, 2002

    ISTCP-V:             Professor Peter Politzer, New Orleans (LA, USA), July 20 - 26, 2005

    ISTCP-VI :           Professor Yan Alexander Wang, Vancouver (BC, Canada), July 19 - 24, 2008

    ISTCP-VI I:          Professor Hiromi Nakai, Waseda (Tokyo, Japan), September 2 - 8, 2011

    ISTCP-VIII:         Professor Péter Surján, Eötvös (Budapest, Hungary), August 25 – 31, 2013.

     

     

    The 2016 venue offered the possibility for the approximately 300 participants from 26 countries to join the Congress. Speakers from each of the countries were joined by students from 9 countries.  Despite being nearly 2000 km from any sea coast (1200 km, if one counts the Arctic Ocean outlet Hudson Bay),  this Congress continued to reflect the strong international characteristics of ISTCP. Countries sending 4 or more delegates include China, Denmark, France, Germany, Hungary, Israel, Japan, Mexico, Netherlands, Norway, Switzerland, and the United Kingdom, besides the U.S.A.

     

    The International Society for Theoretical Chemical Physics, ISTCP, was founded in 1990 by Professor János Ladik at the University of Erlangen, Germany. ISTCP has the objectives to promote theoretical developments at the frontier between physics and chemistry. Additionally the goal is to allow younger researchers to interact with leading contributors of the field at regularly organized International Congresses. The Society involves an Honorary Board, a Board of Directors gathering together about 60 scientists (including 5 Nobel Laureates and 2 Wolf Prize laureates) in the fields of Theoretical Chemistry and Physics, and a Board of National Representatives covering about 35 countries/regions. The current President, since July 2000, is Professor Erkki J. Brändas, from Uppsala University, Sweden.

     

    ISTCP Congress Proceedings have been published regularly in the special issues of the International Journal of Quantum Chemistry (IJQC) and partly (2002, 2008) co-published in special volumes of Progress in Theoretical Chemistry and Physics (PTCP). Following this tradition, a small and highly targeted set of articles were solicited from researchers in several forefront fields represented at ISTCP IX.  These 11 articles are divided into 4 reviews, 3 tutorial reviews, 2 perspectives and 2 papers.

     

    ISTCP-IX was organized into 9 thematic Symposia, plus a special symposium honouring Per-Olov Löwdin.  The co-organizers of each of the symposia had significant latitude in inviting leading scientists in their areas, with attention paid to overall geographical, career stage and gender diversity.  Moreover, in an effort to stimulate conversation and cross-disciplinary inquiries, each speaker was limited to only 1 talk, and there were never more than 3 parallel sessions.  It is the careful thought and hard work of the Symposium Organizers that contributed to the success of the Congress.  The Symposia and their Organizers are:

     

     1. Accurate Thermochemistry (Angela Wilson, Branko Ruscic)

     2. Chemical Insights (Paul Ayers, Pedro Salvador)

     3. Complex Systems (Jiali Gao, Nandini Ananth)

     4. Dynamics (George Schatz, Keli Han)

     5. Electronic Structure (Piotr Piecuch, Jiri Pittner)

     6. Subsystems in Density Functional Theory (Tomasz Wesolowski, Christoph Jacob)

     7. Emerging Methods for Quantum N-body Problem (Seiichiro Ten-no, Edward Valeev)

      8. Molecular Properties (Trygve Helgaker)

      9. Per-Olov Löwdin Symposium (Erkki Brändas)

    10. Relativistic Methods (Wenjian Liu, Jochen Autschbach)

     

    In addition to symposia, there were 9 plenary talks for which all participants were gathered.  The early and enthusiastic support of the plenary speakers were critical to providing high visibility for the conference, and we are grateful to them.

    1. Kim Baldridge, Structure-Property Relationships of Curved Aromatic Materials from First Principles

    2. Ria Broer, Theoretical and Computational Studies for the Design of Organic Photovoltaic Materials

    3. Benedetta Mennucci, Ab Initio Simulation of the Optical Spectroscopy of Multichromophoric Systems

    4. William Miller, Symmetrical Quasi-Classical Model for Classical Molecular Dynamics Simulations of Electronically Non-adiabatic Processes

    5. Debashis Mukherjee, A Survey of the Unitary Group Adapted MRCC and MRPT Theories: SU vs SS Approaches

    6. Martin Quack, The Quantum Dynamics of Chiral and Achiral Molecules including Electroweak Parity Violation: Theory and Experiment

    7. Andreas Savin, Multireference Density Functional Theory

    8. Henry F. Schaefer III

    9. Tamar Seideman, Coherent Alignment in Complex Systems

     

    This Preface does not allow a comprehensive account of all the excellent contributions to the conference or to the articles submitted to these proceedings. The 4 Reviews consider relativistic treatment of molecular properties, charge transfer in molecular crystals and in organic polymeric materials, and advances in subsystem embedding.  These are complemented by Tutorial Reviews on molecular motors, the inverse approach to exchange-correlation potentials, and the random phase approach in the context of reduced density matrices.  One full paper considers the chemistry of new super heavy elements and the other on data considerations in petascale computations of chemical and biological systems.  There are Perspectives on non-collinear electronic structure calculations and calculations of atoms and molecules in strong magnetic fields.  The articles in the proceedings can be grouped roughly into extension of theory and calculations into much larger systems than could be considered just a few years ago and extension of precision in theory and calculations.

     

    We are grateful to all organizers for their exceptional work. In particular we want to thank Professor Janos Ladik, Founder of the Society and Honorary Chair. We were sorry to learn that he could not participate in person but his kind interest and strong support in the various matters of the venue were indeed a positive factor. We are indebted to our excellent organizing committee that guided us in producing a well-balanced, global perspective on cutting-edge chemical physics: Gustavo Aucar, T. Daniel Crawford, Peter Gill, Anna Krylov, Hiromi Nakai, Katarzyna Pernal, Péter Surján and Ágnes Szabados. We are also grateful to all session chairs, speakers, poster presenters, as well as all student volunteers, contributing significantly to the great success of the meeting. For more details regarding the Congress we refer to our web site http://istcp-2016.org/.

     

    The ISTCP-IX Congress took place at the Alerus Center, near the University of North Dakota campus. The assistance of the staff at the Alerus Center and at the Greater Grand Forks Convention and Visitors Bureau were critical in facilitating an event of this complexity in this city of only 60,000 people.  But, most of all, it was the unwavering support of former UND President Robert Kelley, Vice President of Academic Affairs and Provost Tom DiLorenzo, Vice President for Research and Economic Development Grant McGimpsey, and Division of Research Staff Cathy Lerud and Carla Kellner that made this happen.

     

    We are pleased to express our sincere thanks to our sponsors.  In addition to generous support from the University of North Dakota and the Greater Grand Forks Convention and Visitors Bureau, which allowed low-cost registration and accommodations for students, we are pleased to be able to acknowledge additional support from Physical Chemistry Chemical Physics and Department of Energy. These contributions from our sponsors have enabled us to maintain the high-quality standard of the Congress.

     

    The guest editors of this Special Issue, finally, want to thank the authors, who accepted our invitation to contribute to these proceedings, and in so doing provide a perspective of some cutting edge areas of inquiry in chemical physics.  The IXth Congress of ISTCP included both these areas and many more. We hope that all researchers with a great interest in theory and methods related to fundamental scientific problems and future progress of our field will appreciate this volume.

     

    Mark Hoffmann

    Erkki Brändas

     

     

  • Perotti, Elisabetta
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Extraction of Polarization Parameters in the ‾pp → Ω̄Ω Reaction2018In: FAIRNESS 2017: Fair Next Generation Scientists 2017, 2018, article id UNSP 012019Conference paper (Refereed)
    Abstract [en]

    A method to extract the polarization of Omega hyperons produced via the strong interaction is presented. Assuming they are spin 3/2 particles, the corresponding spin density matrix can be written in terms of seven non-zero polarization parameters, all retrievable from the angular distribution of the decay products. Moreover by considering the full decay chain Omega ->Lambda K -> p pi K the magnitude of the asymmetry parameters beta Omega and gamma Omega can be obtained. This method, applied here to the specific Omega case, can be generalized to any weakly decaying hyperon and is perfectly suited for the PANDA experiment where hyperon-antihyperon pairs will be copiously produced in proton-antiproton collisions. The aim is to take a step forward towards the understanding of the mechanism that reigns strangeness production in these processes.

  • Lundberg, Pranee
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Perceptions and Practices of Breastfeeding among Somalian Immigrant Women in Sweden2018Conference paper (Refereed)
    Abstract [en]

    By providing optimal nutrition and health benefits to baby and mother, breastfeeding is the most favorable feeding option for infants. The aim of this qualitative study was to describe the perceptions and practices of breastfeeding among Somalian women living in Sweden after migration. Twenty-five Somalian immigrant women participated voluntarily. Data were collected from in-depth individual semi-structured interviews. The interviews took place in an adult school in Uppsala and homes in Uppsala and its surroundings. They were recorded and transcribed verbatim. Qualitative content analysis was used, and the Theory of Planned Behavior was the conceptual framework for the construction of categories and subcategories. Four categories emerged: (i) breastfeeding beneficial but doesn’t always work, (ii) effects of cultural and traditional beliefs, (iii) professional support by health care providers, and (vi) feeling stress after childbirth in the new country. The women perceived breastfeeding as positive, but several barriers led them to the combined use of formula and breastfeeding and the early introduction of supplementary food. Cultural, religious and traditional beliefs influenced their feeding practices. In conclusion, the women had not extensively changed their breastfeeding perceptions and practices due to the change of their environment; they mostly followed their cultural beliefs and traditions. Getting understanding of the women’s beliefs and practices is a first step for providing culturally informed health promotion. Antenatal care intervention programs for Somalis should involve the whole family and support breastfeeding by emphasizing its cultural and religious significance.

  • Wallin, Adéle
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Structural intrusion, flow disturbance and spillway capacity: CFD modeling of the Torpshammar dam2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    At the Torpshammar dam two rectangular beams are situated upstream of the spillway gates to stabilize the sidewalls holding the embankment of the dam. A computational fluid dynamics (CFD) simulation of the dam with the bottom outlets open was made to investigate how the flow and discharge capacity is affected by the beams. The results can be used to avoid unexpected consequences due to turbulence caused by the beams, make the beams strong enough to hold the pressure from the flow and get an estimation of the discharge capacity with the beams. Turbulence is one of the hardest things to simulate so the results were compared with previous simulation work made without the beams and physical model tests to validate the results. Also, a sensitivity analysis was made to investigate the method used.

    The beams lowered the velocity (to 17 m/s) and the discharge capacity (to 255 m3/s) compared to the previous work. The force on the beams was directed upward and downstream. The beams increased the turbulence and the vortex shedding frequency was higher for the beam closest to the outlet. The velocity and discharge capacity differed with 6 % compared to model test results. The results can therefore only be used as an estimation, a more detailed computational model and more computational cells are needed to get a better result. The sensitivity analysis showed that the velocity and turbulence depend on the method and further studies need to be made to decide which method gives the closest similarity with reality.

  • Lopez-Fernandez, Margarita
    et al.
    Åström, Mats
    Bertilsson, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dopson, Mark
    Depth and Dissolved Organic Carbon Shape Microbial Communities in Surface Influenced but Not Ancient Saline Terrestrial Aquifers2018In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, no November, article id 2880Article in journal (Refereed)
  • Tranvik, Lars
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Cole, Jonathan J.
    Prairie, Yves T.
    The study of carbon in inland waters-from isolated ecosystems to players in the global carbon cycle2018In: Limnology and Oceanography Letters, E-ISSN 2378-2242, Vol. 3, no 3, p. 41-48Article in journal (Refereed)
    Abstract [en]

    Limnology, and in particular the study of the aquatic carbon cycle initially focused on lakes as isolated ecosys-tems. Later on, investigations followed of lakes as recipi-ents. Current studies of inland water carbon cycling emphasizes fluxes in and out of lakes and other inland waters, in exchange with both upstream landscapes, down-stream recipients, the atmosphere, and the long term sedi-ment sink. This widening of scope has developed in a combination of fundamental science and research moti-vated by applied problems (e.g., effects of dams and climate change). Given that inland waters receive, process, emit and store carbon in globally significant quantities, we anticipate the field to continue this transition, and anthro-pogenic pressure on the environment to increasingly motivate carbon cycle research. In 2007, we (and other co-authors) published an article that introduced the idea of the " active pipe concept " for inland waters, which states that they are not passive conduits from soil to sea but instead divert large quantities of carbon to the atmosphere and to the sediment sink (Cole et al. 2007). Since the origi-nal presentation of the " active pipe, " there has been sub-stantial progress in our understanding of the inland water carbon cycle and its role in the biogeosphere. In this essay, we describe the evolution that has taken place in our field to not only study aquatic ecosystems as the complex microcosms bound by their basins that they definitely are, but also as active players in global cycles (Fig. 1); and, we describe some important anthropogenic effects on the *Correspondence: lars.tranvik@ebc.uu.se

  • Löfberg, My
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Förståelse för värmestrålning: En kvalitativ intervjustudie som undersöker om en laboration på universitetsnivå ökar förståelsen för relationen mellan fenomenen inom värmestrålning.2018Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Heat radiation is a phenomenon that students find hard to understand. With this in mind a laboratory called Understanding heat radiation was designed during the spring of 2017 with the aim to give the students who performed it a better understanding of the relationship between the four phenomena of heat radiation, absorption, emission, reflection and transmission. The laboratory was divided into two different experiments focusing on different phenomena.The purpose of this study is to investigate through qualitative semi-structured interviews whether the laboratory gives the students a better understanding of the relationship between these four phenomena in heat radiation.The selection for the study was three-year students at Uppsala University, who studied the program of Engineering Physics and who, at the time of the study, just commenced the course Technical Thermodynamics in which the laboratory was included. The result showed that the students themselves experienced an improved understanding of heat radiation. It also showed indications that the preparation for the laboratory and the understanding of IR camera used during the laboratory were important for the students to be able to understand and explain their findings correctly. The students did not reflect whether their explanations of the results of the laboratory were reasonable or not and they never compared the explanations of each experiment with each other. The selection, ie. student with approximately three years of physics studies, did not appear to have played a decisive role in how much the students understood or were able to explain their results.

  • Mantzouki, Evanthia
    et al.
    Beklioǧlu, Meryem
    Brookes, Justin D.
    de Senerpont Domis, Lisette Nicole
    Dugan, Hilary A.
    Doubek, Jonathan P.
    Grossart, Hans-Peter
    Nejstgaard, Jens C.
    Pollard, Amina I.
    Ptacnik, Robert
    Rose, Kevin C.
    Sadro, Steven
    Seelen, Laura
    Skaff, Nicholas K.
    Teubner, Katrin
    Weyhenmeyer, Gesa A.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Ibelings, Bastiaan W.
    Snapshot Surveys for Lake Monitoring, More Than a Shot in the Dark2018In: Frontiers in Ecology and Evolution, E-ISSN 2296-701X, Vol. 6, no November, article id 201Article in journal (Refereed)
  • Lopez-Fernandez, Margarita
    et al.
    Simone, Domenico
    Wu, Xiaofen
    Soler, Lucile
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Nilsson, Emelie
    Holmfeldt, Karin
    Lantz, Henrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Bertilsson, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dopson, Mark
    Metatranscriptomes Reveal That All Three Domains of Life Are Active but Are Dominated by Bacteria in the Fennoscandian Crystalline Granitic Continental Deep Biosphere2018In: mBio, ISSN 2161-2129, E-ISSN 2150-7511, Vol. 9, no 6, article id e01792-18Article in journal (Refereed)
    Abstract [en]

    The continental subsurface is suggested to contain a significant part of the earth's total biomass. However, due to the difficulty of sampling, the deep subsurface is still one of the least understood ecosystems. Therefore, microorganisms inhabiting this environment might profoundly influence the global nutrient and energy cycles. In this study, in situ fixed RNA transcripts from two deep continental groundwaters from the Äspö Hard Rock Laboratory (a Baltic Sea-influenced water with a residence time of <20 years, defined as "modern marine," and an "old saline" groundwater with a residence time of thousands of years) were subjected to metatranscriptome sequencing. Although small subunit (SSU) rRNA gene and mRNA transcripts aligned to all three domains of life, supporting activity within these community subsets, the data also suggested that the groundwaters were dominated by bacteria. Many of the SSU rRNA transcripts grouped within newly described candidate phyla or could not be mapped to known branches on the tree of life, suggesting that a large portion of the active biota in the deep biosphere remains unexplored. Despite the extremely oligotrophic conditions, mRNA transcripts revealed a diverse range of metabolic strategies that were carried out by multiple taxa in the modern marine water that is fed by organic carbon from the surface. In contrast, the carbon dioxide- and hydrogen-fed old saline water with a residence time of thousands of years predominantly showed the potential to carry out translation. This suggested these cells were active, but waiting until an energy source episodically becomes available.IMPORTANCE A newly designed sampling apparatus was used to fix RNA under in situ conditions in the deep continental biosphere and benchmarks a strategy for deep biosphere metatranscriptomic sequencing. This apparatus enabled the identification of active community members and the processes they carry out in this extremely oligotrophic environment. This work presents for the first time evidence of eukaryotic, archaeal, and bacterial activity in two deep subsurface crystalline rock groundwaters from the Äspö Hard Rock Laboratory with different depths and geochemical characteristics. The findings highlight differences between organic carbon-fed shallow communities and carbon dioxide- and hydrogen-fed old saline waters. In addition, the data reveal a large portion of uncharacterized microorganisms, as well as the important role of candidate phyla in the deep biosphere, but also the disparity in microbial diversity when using standard microbial 16S rRNA gene amplification versus the large unknown portion of the community identified with unbiased metatranscriptomes.

  • McCallister, S. L.
    et al.
    Ishikawa, N. F.
    Kothawala, Dolly
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Biogeochemical tools for characterizing organic carbon in inland aquatic ecosystems2018In: Limnology and Oceanography Letters, E-ISSN 2378-2242, Vol. 3, p. 444-457Article in journal (Refereed)
    Abstract [en]

    Integration of inland waters into regional and global carbon (C) budgets requires a comprehensive understand- ing of factors regulating organic carbon (OC) delivery and in situ processing. This study reviews advances in optical, molecular, and isotopic approaches to resolve the sources, ages, and transformations of OC in aquatic systems. OC characterization using excitation emission matrix spectra, Fourier transform ion cyclotron mass spectrometry, and nuclear magnetic resonance provides detailed molecular level insight. Radiocarbon isotopic approaches and compound-specific techniques resolve the input, metabolic fate, and turnover time of OC in ecosystems ranging in size from streams to the open ocean. Accumulating evidence suggests that aquatic OC is composed of diverse biogeochemical components. We conclude with enduring and emerging questions that underscore the role of inland systems in the global C cycle and propose unique combinations of approaches to better discern their role in the delivery and transformation of OC from soils to seas.

  • Riise, Gunnhild
    et al.
    Müller, Roger André
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Haaland, Ståle
    Weyhenmeyer, Gesa A.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Acid rain — a strong external driver that has suppressed water colour variability between lakes2018In: Boreal environment research, ISSN 1239-6095, E-ISSN 1797-2469, Vol. 23, no February, p. 69-81Article in journal (Refereed)
    Abstract [en]

    Increasing water colour observed in lakes in the northern hemisphere is frequently explained by several factors, including the decrease in acid deposition, climate change and recently increased concentrations of Fe. As the anthropogenic sulphate deposition levels off, pressure from an external lake quality driver with regional coverage declines. To inves- tigate the impact of acid rain reduction on lake colour variability, we examined 25 lakes in a lake- district of southeastern Norway by analyzing atmospheric deposition, climate and water chemistry data from 1983 to 2012. We observed a marked shift in lake colour after the wet year 2000, probably triggered by a flush of water that has lifted the base line for lake colour to a higher level. Lakes had synchronous temporal trends of many water quality vari- ables, such as conductivity and several major ions. Our data suggest that this is a response to reduced acid deposition. In contrast, lake colour and colour related variables such as Fe and TOC, showed moderate to low coherence. We propose that declined pressure from a strong external driver promotes the importance of climate variability and local catchment specific processes, giving rise to increased colour variability between lakes with time. Introduction

  • Karlsson, Olov
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Tidén, Tobias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Påverkas vardagslivet av kontinuerlig glukosmätare: Att vara vårdnadshavare till ett barn med typ 1 diabetes2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • Henriksson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    King David's Altar in Jerusalem Dated by the Bright Appearance of Comet Encke in 964 BC2018In: Annals of Archaeology, Vol. 1, no 1, p. 30-37Article in journal (Refereed)
    Abstract [en]

    At the time corresponding to our end of May and beginning of June in 964 BC a bright comet with a very long tail dominated the night sky of the northern hemisphere. It was Comet Encke that was very bright during the Bronze Age, but today it is scarcely visible to the naked eye. It first appeared as a small comet close to the zenith, but for every night it became greater and brighter and moved slowly to the north with its tail pointing southwards. In the first week of June the tail was stretched out across the whole sky and at midnight it was visible close to the meridian. In this paper the author wishes to test the hypothesis that this appearance of Comet Encke corresponds to the motion in the sky above Jerusalem of “the sword of the Angel of the Lord”, mentioned in 1 Chronicles, in the Old Testament. Encke was first circumpolar and finally set at the northern horizon on 8 June in 964 BC at 22. This happened according to the historical chronology between 965 and 960 BC. The calculations of the orbit of Comet Encke have been performed by a computer program developed by the author. It has been calibrated from depictions on Swedish rock-carvings, Chinese texts and Sumerian cylinder seals and gives useful results at least back to 2654 BC.

  • Johnsson, Kajsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Icke farmakologiska behandlingsmetoder vid depression under graviditet: En systematisk litteraturöversikt2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    ABSTRACT 

    Background 

    Depression is common among young women of childbearing age, which means that childbirth occurs during a part of life when many women are mentally vulnerable. About 10 to 20 percent of all pregnant women suffer from depression of varying degree during the antenatal period. Depression increases the risk of growth retardation in the fetus, premature birth and postpartum depression and complicates the bonding between mother and child. The current perception is that women who are taking antidepressants before pregnancy should continue to medicate and that insertation should be made when needed. However, many women do not want to use antidepressant drugs during pregnancy out of fear of adverse affects on the fetus, and for these women more options are needed. Midwifery includes supporting and nursing women during pregnancy, why knowledge about treatment options is important to the occupational group.

    Purpose 

    The purpose of this thesis was to investigate the non-pharmacological treatments available in pregnancy depression and their advantages and disadvantages.

    Method 

    A systematic review has been made where 28 articles were included in a total of 659 reviewed titles, 110 reviewed abstracts and 44 articles reviewed in full text. The included articles were analyzed with qualitative content analysis and quality assayed according to Willman, Stoltz and Bahtsevani, (2016).

    Results 

    The analysis of the results showed that many forms of non-pharmacological treatments may have mitigating or curing effects in the event of depression during pregnancy. It appears that treatment with yoga, treatment with mind-body therapy, treatment given to couples, treatment given digitally, treatment given in a group and treatment with psychotherapy or counseling  has a positive effect, albeit to a different extent. The result provides support for complementing the basic program of customized maternity care, which is desirable and helps women with antenatal depression and that the positive effect often persists after childbirth.

    Conclusion 

    This degree project showed that many non-pharmacological treatment methods can help women with antenatal depression. Access to treatment methods was usually high and few negative effects were observed. Women can from this be informed that research has shown that in addition to antidepressant medication there are non-pharmacological treatment methods that have a good effect on depression during pregnancy. Further research can show whether treatment options could be offered within the framework of maternal health care programs, and whether it is possible to reduce pregnancy complications caused by depression through these alternative therapies.

    KEYWORDS

    Antenatal depression, depression, maternity, perinatal depression, pregnancy, therapy, treatment

  • Hawkes, Jeffrey A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Patriarca, Claudia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Sjöberg, Per J. R.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Tranvik, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Extreme isomeric complexity of dissolved organic matter found across aquatic environments2018In: Limnology and Oceanography Letters, E-ISSN 2378-2242, Vol. 3, p. 21-30Article in journal (Refereed)
    Abstract [en]

    The natural aquatic environment contains an enormous pool of dissolved reduced carbon, present as ultra- complex mixtures that are constituted by an unknown number of compounds at vanishingly small concentrations. We attempted to separate individual structural isomers from several samples using online reversedphase chromatography with selected ion monitoring/tandem mass spectrometry, but found that isomeric complexity still presented a boundary to investigation even after chromatographic simplification of the samples. However, it was possible to determine that the structural complexity differed among samples. Our results also suggest that extreme structural complexity was a ubiquitous feature of dissolved organic matter (DOM) in all aquatic systems, meaning that this diversity may play similar roles for recalcitrance and degradation of DOM in all tested environments.

  • Bravo, Andrea Garcia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab. bDepartment of Marine Biology and Oceanography, Institut de Ciències del Mar, Consejo Superior de Investigaciones Científicas, Barcelona, Catalonia, Spain.
    Peura, Sari
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Buck, Moritz
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Osman, Omneya
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Mateos-Rivera, Alejandro
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Herrero Ortega, Sonia
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Schaefer, Jeffra K.
    Bouchet, Sylvain
    Tolu, Julie
    Björn, Erik
    Bertilsson, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Methanogens and Iron-Reducing Bacteria: the Overlooked Members of Mercury-Methylating Microbial Communities in Boreal Lakes2018In: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 84, no 23, p. 1-16, article id e01774-18Article in journal (Refereed)
    Abstract [en]

    Methylmercury is a potent human neurotoxin which biomagnifies in aquatic food webs. Although anaerobic microorganisms containing the hgcA gene potentially mediate the formation of methylmercury in natural environments, the di- versity of these mercury-methylating microbial communities remains largely unex- plored. Previous studies have implicated sulfate-reducing bacteria as the main mer- cury methylators in aquatic ecosystems. In the present study, we characterized the diversity of mercury-methylating microbial communities of boreal lake sediments us- ing high-throughput sequencing of 16S rRNA and hgcA genes. Our results show that in the lake sediments, Methanomicrobiales and Geobacteraceae also represent abun- dant members of the mercury-methylating communities. In fact, incubation experi- ments with a mercury isotopic tracer and molybdate revealed that only between 38% and 45% of mercury methylation was attributed to sulfate reduction. These re- sults suggest that methanogens and iron-reducing bacteria may contribute to more than half of the mercury methylation in boreal lakes.

  • Bravo, Andrea Garcia
    et al.
    Kothawala, Dolly
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Attermeyer, Katrin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Tessier, Emmanuel
    Bodmer, Pascal
    Amouroux, David
    Cleaning and sampling protocol for analysis of mercury and dissolved organic matter in freshwater systems2018In: MethodsX, ISSN 1258-780X, E-ISSN 2215-0161, Vol. 5, p. 1017-1026Article in journal (Refereed)
    Abstract [en]

    Mercury (Hg), and in particular its methylated form (methylmercury, MeHg), is a hazardous substance with the potential to produce significant adverse neurological and other health effects. Enhanced anthropogenic emissions and long-range transport of atmospheric Hg have increased Hg concentrations above background levels in aquatic systems. In this context, the Minamata Convention, a global legally binding agreement that seeks to prevent human exposure to Hg, was signed and enforced by 128 countries, and today more than 90 Parties have ratified it. All these Parties have committed to develop Hg monitoring programs to report the effectiveness of the convention. For this purpose, we provide a standardized cleaning and water sampling protocol for the determination of total-Hg and MeHg in freshwaters at ambient levels. As Hg and organic matter are tightly bound, the protocol also describes sample collection for dissolved organic carbon (DOC) concentration and characterization of dissolved organic matter (DOM) composition by fluorescence spectroscopy. This protocol is highly useful to non-experts without a prior background in Hg sampling and analysis, and can serve as a useful basis for national monitoring programs. Furthermore, this protocol should help increase quantitative inventories of DOC, inorganic-Hg (IHg) and MeHg concentrations and DOM composition in freshwater, which are severely lacking at a global scale. • Provides a standardized method to collect water samples for IHg, MeHg, DOC and DOM composition from freshwater ecosystems.

  • Shen, Dandan
    et al.
    Leibniz Inst Balt Sea Res, Sect Biol Oceanog, Warnemunde, Germany.
    Langenheder, Silke
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Juergens, Klaus
    Leibniz Inst Balt Sea Res, Sect Biol Oceanog, Warnemunde, Germany.
    Dispersal Modifies the Diversity and Composition of Active Bacterial Communities in Response to a Salinity Disturbance2018In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, article id 2188Article in journal (Refereed)
    Abstract [en]

    Dispersal can influence the response of bacterial communities to environmental changes and disturbances. However, the extent to which dispersal contributes to the community response in dependence of the character and strength of the disturbance remains unclear. Here, we conducted a transplant experiment using dialysis bags in which bacterioplankton originating from brackish and marine regions of the Saint Lawrence Estuary were reciprocally incubated in the two environments for 5 days. Dispersal treatments were set-up by subjecting half of the microcosms in each environment to an exchange of cells between the marine and brackish assemblages at a daily exchange rate of 6% (v/v), and the other half of microcosms were kept as the nondispersal treatments. Bacterial 16S rRNA sequencing was then used to examine the diversity and composition of the active communities. Alpha diversity of the marine communities that were exposed to the brackish environment was elevated greatly by dispersal, but declined in the absence of dispersal. This indicates that dispersal compensated the loss of diversity in the marine communities after a disturbance by introducing bacterial taxa that were able to thrive and coexist with the remaining community members under brackish conditions. On the contrary, alpha diversity of the brackish communities was not affected by dispersal in either environment. Furthermore, dispersal led to an increase in similarity between marine and brackish communities in both of the environments, with a greater similarity when the communities were incubated in the brackish environment. These results suggest that the higher initial diversity in the brackish than in the marine starting community made the resident community less susceptible to dispersing bacteria. Altogether, this study shows that dispersal modifies the diversity and composition of the active communities in response to a salinity disturbance, and enables the local adjustment of specific bacteria under brackish environmental conditions.

  • Reimer, C.
    et al.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Rubin, Carl-Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Sharifi, A. R.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Ha, N. -T
    Weigend, S.
    Friedrich Loeffler Inst, Inst Farm Anim Genet, Holtystr 10, D-31535 Neustadt, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Waldmann, K. -H
    Distl, O.
    Univ Vet Med Fdn, Inst Anim Breeding & Genet, Bunteweg 17p, D-30559 Hannover, Germany.
    Pant, S. D.
    Charles Sturt Univ, Sch Anim & Vet Sci, Graham Ctr Agr Innovat, Locked Bag 588,Boorooma St, Wagga Wagga, NSW, Australia.
    Fredholm, M.
    Univ Copenhagen, Dept Vet & Anim Sci, Gronnegardsvej 3, DK-1870 Frederiksberg C, Denmark.
    Schlather, M.
    Univ Mannheim, Sch Business Informat & Math, A5 6, D-68131 Mannheim, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Simianer, H.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Analysis of porcine body size variation using re-sequencing data of miniature and large pigs2018In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 19, article id 687Article in journal (Refereed)
    Abstract [en]

    Background: Domestication has led to substantial phenotypic and genetic variation in domestic animals. In pigs, the size of so called minipigs differs by one order of magnitude compared to breeds of large body size. We used biallelic SNPs identified from re-sequencing data to compare various publicly available wild and domestic populations against two minipig breeds to gain better understanding of the genetic background of the extensive body size variation. We combined two complementary measures, expected heterozygosity and the composite likelihood ratio test implemented in "SweepFinder", to identify signatures of selection in Minipigs. We intersected these sweep regions with a measure of differentiation, namely F-ST, to remove regions of low variation across pigs. An extraordinary large sweep between 52 and 61 Mb on chromosome X was separately analyzed based on SNP-array data of F-2 individuals from a cross of Goettingen Minipigs and large pigs. Results: Selective sweep analysis identified putative sweep regions for growth and subsequent gene annotation provided a comprehensive set of putative candidate genes. A long swept haplotype on chromosome X, descending from the Goettingen Minipig founders was associated with a reduction of adult body length by 3% in F-2 cross-breds. Conclusion: The resulting set of genes in putative sweep regions implies that the genetic background of body size variation in pigs is polygenic rather than mono-or oligogenic. Identified genes suggest alterations in metabolic functions and a possible insulin resistance to contribute to miniaturization. A size QTL located within the sweep on chromosome X, with an estimated effect of 3% on body length, is comparable to the largest known in pigs or other species. The androgen receptor AR, previously known to influence pig performance and carcass traits, is the most obvious potential candidate gene within this region.

  • Sundblad, Arvid
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Identifieringsmöjligheter av feljusterad bussdörr: - Studie av möjliga signalanalyser av dörrpositioner för att finna dörrar som kan orsaka problem2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In the bus industry, it is well-known that bus doors often cause buses to stand at a stop after either a door could not be opened or closed. This causes huge costs for the bus owner. Therefore, it is desirable to be able to predict whether a door's behaviour begins to become too close to causing such an event. Based on this background, this study has been completed at Scania CV AB in Södertälje in order to find out which signals from a door system that can be used to determine if a door is at risk of failing. The main problems that this study is based on are: - Which existing sensors can be used to measure the most common errors before causing a bus that cannot drive? - Is it possible to find a model that can indicate how to adjust speed and attenuation to get a "perfect" adjusted door? These questions were studied by making measurements on a Scania City Wide bus with double inswing door leafs where measurements were made only on the rear door leaf and for its closing behaviour. To make measurements on the door an oscilloscope was used which measured the voltage across a potentiometer with a voltage that varied depending on how open the door was. Another measurement was made on the embedded control system in the bus body. The noise-corrupted measurement data was filtered with a simple type of filter, called moving average filter. In order to find different methods that predict if there were any errors on the door's settings or components, curves were examined over the doors' position during a closing event. One thing that was studied was which position value that was present when the door couldn’t get closed more. Another thing was the curve's slope in different segments of the closing. The slope of the curve was calculated by using the least squares method, which is a mathematical method in linear algebra. Based on the slope in some curve segments of a closing event, a model was created that could guess the door closing time as well as the damping. This model functioned in a convincing way for measurements from the test bus that was used when developing the model. Other models that the study resulted in was one that could warn if the potentiometer values began to approach a limit when the door could no longer be closed, as well as a model that calculated the closing and opening times of the door. Through these models, the idea was that a warning signal could be sent to a system that warned that the door should be adjusted. When some measurements for the guess model were made on another bus, it gave indications that the model did not work as well as the test bus. But one conclusion that could be drawn was that there was an indication that the door was misaligned, even though the model guessed wrong for the present settings. Another conclusion was that it is likely possible to proceed further with some research on this model to find a new model that is somewhat more general for all individual bus doors.

  • Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Osteoglycin - A switch from angiogenesis to T-cell recruitment?2018In: EBioMedicine, E-ISSN 2352-3964, Vol. 35, p. 22-23Article in journal (Other academic)
  • Howner, Katarina
    et al.
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Natl Board Forens Med, Div Forens Psychiat Stockholm, Dept Forens Psychiat, Stockholm, Sweden.
    Andine, Peter
    Natl Board Forens Med, Div Forens Psychiat Gothenburg, Dept Forens Psychiat, Gothenburg, Sweden; Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad,Ctr Eth Law & Mental Hlth, Gothenburg, Sweden; Sahlgrens Univ Hosp, Forens Psychiat Clin, Gothenburg, Sweden.
    Bertilsson, Goran
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Hultcrantz, Monica
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Lindström, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Mowafi, Frida
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Snellman, Alexandra
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Hofvander, Bjorn
    Lund Univ, Dept Clin Sci Lund Child & Adolescent Psychiat, Lund, Sweden.
    Mapping Systematic Reviews on Forensic Psychiatric Care: A Systematic Review Identifying Knowledge Gaps2018In: Frontiers in Psychiatry, ISSN 1664-0640, E-ISSN 1664-0640, Vol. 9, article id 452Article, review/survey (Refereed)
    Abstract [en]

    Background: Forensic psychiatric care treats mentally disordered offenders who suffer mainly from psychotic disorders, although comorbidities such as personality disorders, neurodevelopmental disorders, and substance abuse are common. A large proportion of these patients have committed violent crimes. Their care is involuntary, and their caregivers' mission is complex: not only to rehabilitate the patient, but also to consider their risk for reoffending and their risk to society. The objective of this overview of systematic reviews is to identify, appraise, and summarize the existing knowledge in forensic psychiatric care and identify knowledge gaps that require further research.

    Methods: We undertook a systematic literature search for systematic reviews in five defined domains considered important in daily clinical practice within the forensic psychiatric care: (1) diagnostic assessment and risk assessments; (2) pharmacological treatment; (3) psychological interventions; (4) psychosocial interventions, rehabilitation, and habilitation; and (5) restraint interventions. The target population was mentally disordered offenders (forensic psychiatric patients aged >15 years). Each abstract and full text review was assessed by two of the authors. Relevant reviews then were assessed for bias, and those with moderate or low risk of bias were included.

    Results: Of 38 systematic reviews meeting the inclusion criteria, only four had a moderate risk of bias. Two aimed to incorporate as many aspects of forensic psychiatric care as possible, one investigated non-pharmacological interventions to reduce aggression in forensic psychiatric care, and one focused on women with intellectual disabilities in forensic care. However, most of the primary studies included in these reviews had high risks of bias, and therefore, no conclusions could be drawn. All of our identified domains must be considered knowledge gaps.

    Conclusion: We could not answer any of our research questions within the five domains because of the high risk of bias in the primary studies in the included systematic reviews. There is an urgent need for more research on forensic psychiatric care since all of our studied domains were considered knowledge gaps.

  • Williams, Kathryn J.H.
    et al.
    Lee, Kate E.
    Hartig, Terry
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Housing and Urban Research. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Sargent, Leisa D.
    Williams, Nicholas S.G.
    Johnson, Katherine A.
    Conceptualising creativity benefits of nature experience: Attention restoration and mind wandering as complementary processes2018In: Journal of Environmental Psychology, ISSN 0272-4944, E-ISSN 1522-9610, Vol. 59, p. 36-45Article in journal (Refereed)
    Abstract [en]

    Accumulating evidence indicates that time spent in natural environments promotes creativity, but few researchers have considered how this occurs. We evaluate two candidate mechanisms, attention restoration and mind wandering. We compare the accounts in terms of attentional focus, brain network activation, cognitive effects, and the temporal progression of these processes across the stages of creativity. Based on this analysis, we propose that (1) gentle shifts between externally oriented soft fascination and internally oriented mind wandering can occur during nature experience; (2) this provides the basis for mutually reinforcing pathways that enhance attention control following nature experience; and (3) mind wandering might support additional benefits for creativity, including flexibility and new associations of ideas. We propose research to test the proposed pathways, including the conditions under which environments influence creativity, the ebb and flow of attention orientation during environmental experience, and the links between attentional focus, brain network activation and creativity.

  • Terranova, Nadia
    et al.
    Merck Serono SA, Merck Inst Pharmacometr, Zurich, Switzerland.
    Smith, Mike K.
    Pfizer, Global Clin Pharmacol, Sandwich, Kent, England.
    Nordgren, Rikard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Comets, Emmanuelle
    INSERM, UMR 1137, IAME, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, IAME, UMR 1137, Paris, France.
    Lavielle, Marc
    Inria Ile De France, Paris, France;Ecole Polytech, Paris, France.
    Harling, Kajsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Hooker, Andrew
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Sarr, Celine
    Pharmetheus, Uppsala, Sweden.
    Mentre, France
    INSERM, UMR 1137, IAME, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, IAME, UMR 1137, Paris, France.
    Yvon, Florent
    EMBL European Bioinformat Inst, Cambridge, England; Barcelona Supercomp Ctr, Barcelona, Spain.
    Swat, Maciej J.
    EMBL European Bioinformat Inst, Cambridge, England; Simcyp, Sheffield, S Yorkshire, England.
    The Standard Output: A Tool-Agnostic Modeling Storage Format2018In: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, ISSN 2163-8306, Vol. 7, no 9, p. 543-546Article in journal (Other academic)
  • Östling, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    High Accuracy Speed and Angular Position Detection by Dual Sensor2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    For many decades there has been a need in many industries to measure speed and position of ferrous gears. This is commonly done by converting passing gear teeth from trigger wheels to electrical impulses to calculate speed and angular position.

    By using Hall effect sensors or Giant Magnetoresistance sensors (GMR), a zero speed detection of gear teeth is possible while at the same time be cheap to produce and durable for harsh environments.

    A specially designed trigger-wheel (cogwheel created for measurements) with gear teeth in a specific pattern, exact position can be detected by using a dual sensor, even when no earlier information is available. The new design of trigger-wheel also makes this new method more accurate and universal compared to previous solutions.

    This thesis demonstrates and argues for the advantages of using a dual sensor for speed and angular position detection on gear wheels. Were one sensor do quantitative measurements for pattern detection in the teeth arrangements and the other sensor do qualitative measurements for position detection.

  • Nilsson, Joacim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Laddinfrastruktur för elbilar vid stora trafikflöden och event: När uppstår problem och vilka är dess portabla lösningar?2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The share of cars being powered by electricity is rising in Sweden. So far, this has seldom been causing queues at charging stations but if the rise continues as expected, it might potentially be a problem in the future. This thesis aims to shed light on when this might become a problem in a certain area and give example of a potential solution for that case. Three scenarios with different shares of cars being electric is analyzed with a simple model of a system with fast chargers for an area with a highly variable traffic flow. The arrival times to the system is derived from measured traffic flow and extrapolated up until 2030 and a charging time is set based on assumed travel behavior. A comparison is made between the expected electricity consumption using this approach and actual data from a fast charging station. The comparison indicates that electric cars are not being used for the winter time cross-country trips analyzed here in the same extent as conventional cars. The potential to keep the number of stationary fast chargers down using a portable solution with Li-ion battery storage with and without attached production of electricity for situations with a higher than normal charging demand is then investigated. A containerized Li-ion battery solution of 760 kWh has the potential to replace two 50 kW fast chargers in the studied case.

  • Vilhelmsson, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Förebyggande underhåll av elmotorer2018Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den här rapporten berättar om mitt examensarbete inom förebyggande underhåll på Pappersmaskin 12 hos Holmen Paper i Hallstavik. Förebyggande underhåll är en väldigt viktig del av underhållsarbetet för att öka anläggningens tillgänglighet. Ett stopp kostar upp mot 100tkr per timme så även en liten ökning i tillgänglighet kan spara stora pengar. De frågeställningar som rapporten ämnade att svara var:

    - Hur ser ett optimalt förebyggande underhåll ut? - Varför går motorer sönder, finns det något samband mellan motorhaverier? - Finns det vissa problempositioner i processen, och hur ska FU utformas där? - Hur ser det förebyggande motorunderhållet ut på Hallstaviks pappersbruk idag? - finns det likheter/skillnader mellan det arbetet och leverantörernas rekommendationer?

    För att visa på detta så genomfördes intervjuer med personal, genomgång av data från historiska arbetsordrar samt studiebesök vid ABB service center.  I rapporten beskriver jag olika rekommenderade underhållsåtgärder och jämför dessa med hur man arbetar i Hallstavik. Utöver detta så presenterar jag resultat på vilka positioner det är mest problem med och vilka symptom och orsaker som visats i samband med att en arbetsorder har skrivits. Det framgick att den position som var hårdast drabbad var motorn för formervalsen och att den vanligaste orsaken var vibrationer.

  • Holmberg, Måns
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Dancila, Dragos
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Rydberg, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Hjörvarsson, Björgvin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Jansson, Ulf
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Marattukalam, Jithin J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Johansson, Niklas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Andersson, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Direct metal laser sintering printed millimeter and submillimeter waveguides2018Conference paper (Other academic)
  • Halvarsson, Hampus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Automated Testing of HVDC Control & Protection Systems: A study on Automated Regression Testing2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Testing is an important activity when developing a system. Testing requires resources in terms of time, labour and money. By correctly automating the tests, the development time may either be shortened or there will be a possibility to run more tests. ABB in Ludvika has developed MACH, a control & protection system for HVDC (high power electrical transmission over long distances) applications. During development of the control & protection system for each HVDC project, which are all unique, the system is today tested manually, which takes considerable time.This thesis project studies the possibility of automating parts of the MACH system tests, by investigating current testing procedures, the control & protection system itself, and how a test tool may interact with the system. Using this information a test framework, aimed towards test automation, was created, and a simple test execution tool was developed. A new test case, a combination of multiple smaller test cases, ranon the system using the test execution tool.The outcome proves the proof of concept of automating parts of the system tests.The economics and the scope of the automated testing however, is dependent on how automation is implemented.

  • Brykt, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Signals and Systems Group.
    Development of a Digital Optimal Filter Platform2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This report is the result of a Master Thesis project which is a part of the Master programme in Electrical Engineering at Uppsala universitet.

    The purpose of this Master Thesis project is to develop an embedded platform for the design and implementation of optimal digital filters, in particular, the Kalman and the Wiener filter. In this project these filters are used for noise reduction on noisy signals. The project is a further development of a previous Master Thesis project where a Universal Filter Bank was developed. The Filter Bankis used for designing and implementing various linear digital filters such as lowpass, highpass, bandpass and bandstop. The Filter Bank is a hand held box with two input and two output connections and a human-device interface (HDI) including a Liquid Crystal Display (LCD) and a keypad. It contains anti-aliasing and reconstruction (analog) filters and an ARM 32-bit Microcontroller Unit (MCU) which is programmed in the C programming language. The HDI lets the user specify a desired digital filter.

    In this project the Kalman and Wiener filtering algorithms were first developed in MATLAB and tested with simulated autoregressive–movingaverage (ARMA) processes (signals) in additive white noise. Aftershown to work, they were implemented on the ARM 32-bit MCU development kit, and finally ported to the Filter Bank. A user interface specially for the specifications of the filters has been created.

    The Kalman and Wiener filtering algorithms have been tested using the same noisy ARMA processes and assessed in terms of the Normalized Mean Square Error (NMSE). The results have shown that both the Wiener and Kalman filters running on the development kit and the Filter Bank are successful in reducing noise. The Kalman filter is shown to perform better than the Wiener filter, which can be due to the extra information about the signal used in the Kalman filter. The performance of both algorithms are heavily dependent on the pre knowledge about the desired signal.

  • Åborg, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Discourse markers and English acquisition.: A corpus-based comparison of essays in year 9 of junior high school and year 3 of senior high school in Sweden2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Using a corpus of school essays of Swedish students in year 9 and 12 of junior and senior high school, the present study compares the level of formality and frequency of discourse markers in the respective year groups. Based on previous literature, discourse markers found in the essays are categorized as either formal or informal. Ten randomly selected essays from each year group are analyzed. The results show that there are discrepancies between grade 9 and year 12 in both formality and frequency of discourse markers. The differences can be connected to second language acquisition and contexts in which the Swedish students acquire English. Outer input of English, made possible by new technology and globalization, has a significant impact on language acquisition, a phenomenon which is new and relatively unexplored.  The results of the current study are discussed in the light of the relevance and impacts of the frequent exposure to English through internet activities and media consumption and how it effects language learning. By focusing on discourse markers, which make up an important part of written and spoken language, I attempt to point out patterns that may be relevant and useful for English teachers. Awareness of how combined mechanisms effect and develop students´ acquisition and how to interpret differences in how students use specific grammatical elements such as discourse markers may be useful as a pedagogical analyzing tool. Not least when it comes to the assessment of essays.

  • Gunnarsson, Hampus
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Ethics and Social Philosophy.
    The Replaceability Argument: An evaluation of a utilitarian argument for the permissibility of purchasing meat2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The thesis is an evaluation of a utilitarian argument for the permissibility of purchasing meat. The argument, which I call the replaceability argument, rests on four premises:

    1. Meat purchases cause animals to be brought into existence.

    2. The animals brought into existence by meat purchases live lives of positive final value.

    3. If the first two premises are true, then meat purchases cause at least as good consequences as any alternative act.

    4. If meat purchases cause at least as good consequences as any alternative act, then meat purchases are permissible.

    The first three premises are examined while the fourth one, representing consequentialism, is assumed to be true. The evaluation results in the conclusion that the argument is unsound because all of the premises evaluated turn out to be either doubtful or false. 

  • Williams, Kathryn J. H.
    et al.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Lee, Kate E.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Hartig, Terry
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Housing and Urban Research.
    Sargent, Leisa D.
    UNSW, UNSW Business Sch, Sydney, NSW, Australia.
    Williams, Nicholas S. G.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Johnson, Katherine A.
    Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
    Conceptualising creativity benefits of nature experience: Attention restoration and mind wandering as complementary processes2018In: Journal of Environmental Psychology, ISSN 0272-4944, E-ISSN 1522-9610, Vol. 59, p. 36-45Article in journal (Refereed)
    Abstract [en]

    Accumulating evidence indicates that time spent in natural environments promotes creativity, but few researchers have considered how this occurs. We evaluate two candidate mechanisms, attention restoration and mind wandering. We compare the accounts in terms of attentional focus, brain network activation, cognitive effects, and the temporal progression of these processes across the stages of creativity. Based on this analysis, we propose that (1) gentle shifts between externally oriented soft fascination and internally oriented mind wandering can occur during nature experience; (2) this provides the basis for mutually reinforcing pathways that enhance attention control following nature experience; and (3) mind wandering might support additional benefits for creativity, including flexibility and new associations of ideas. We propose research to test the proposed pathways, including the conditions under which environments influence creativity, the ebb and flow of attention orientation during environmental experience, and the links between attentional focus, brain network activation and creativity.

  • Ekstrand, Elisabeth
    et al.
    Lund Univ, Dept Hlth Sci, Lund, Sweden;Skane Univ Hosp, Dept Hand Surg, Malmo, Sweden.
    Lexell, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rehabilitation Medicine. Lund Univ, Dept Hlth Sci, Lund, Sweden.
    Brogårdh, Christina
    Lund Univ, Dept Hlth Sci, Lund, Sweden;Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden.
    Test-Retest Reliability of The Participation Domain of the Stroke Impact Scale in Persons with Chronic Stroke2018In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 50, no 9, p. 843-846Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate the test-retest reliability and variability of the Participation domain of the Stroke Impact Scale (SIS Participation) in persons with stroke as it is widely used to assess perceived participation in rehabilitation after stroke.

    Design: A test-retest design. Subjects: Forty-five persons (mean age 65 years) with mild to moderate disability at least 6 months post-stroke.

    Methods: The SIS Participation domain was rated on 2 occasions, 1 week apart. The test-retest reliability of the total score was evaluated using Kappa statistics. The 8 item scores were evaluated by the proportion of participants who rated the same score (percentage agreement, PA) or +/- 1 point (PA <= 1 point) at T1 and T2. The Svensson method was used to evaluate systematic and random disagreement.

    Results: The test-retest reliability of the total score showed excellent agreement (Kappa coefficient = 0.79). The items showed high PA <= 1 point (> 82%). No items, except 2, showed a systematic disagreement, and no items showed a random disagreement according to the Svensson method.

    Conclusion: The SIS Participation domain is reliable in persons with chronic stroke and mild to moderate disability and can be used to assess perceived participation in this population.

  • Woube, Annie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Centre for Gender Research.
    Racing against age?: Gender, age, and body among senior participants in women-only sports races2018In: Loisir et Société, ISSN 0705-3436, E-ISSN 1705-0154, Vol. 41, no 2, p. 297-310Article in journal (Refereed)
    Abstract [en]

    The purpose of this study is to investigate experiences and meaning-making of exercise and participation in races for women-only among Swedish senior women. Positioned within the framework of discourse theory, post-structuralism, and feminism, the article contains an analysis of how the intersection of gender, age, and the aging body affects articulations of meaning among senior participants in written accounts, interviews, and ethnographical fieldwork on women-only races in Sweden. The study shows that the senior women participate in women-only races in relation to (1) an aging, deteriorating body, (2) a health and exercise trend in Western society, (3) a desire for a single-gendered social context, (4) their own imagined physical (in)capability, (5) male-connoted capacities of physical strength, speed, and stamina, and (6) other senior female athletes who function as role models.