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  • Public defence: 2024-03-22 10:15 4004, Uppsala
    Cannarozzo, Simone
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Isomeric yield ratio studies in nuclear reactions and alpha-particle induced fission of Thorium2024Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Despite decades of research since the initial discovery of nuclear fission, numerous unresolved questions still persist. It is known empirically that fission fragments emerge with high angular momentum. The mechanism responsible for the generation of the large angular momenta observed is one of these open questions. Since the characteristics of fission fragments are not directly measurable, experimentally accessible observables are used to derive the angular momenta using nuclear model codes. One of these observables is the yield ratio between fission products produced in different isomeric states, i.e., metastable energy levels of the same nucleus.

    In this thesis, a study of the level density models implemented in the nuclear model code TALYS is presented. Simulated and experimental isomeric yield ratios of a large number of nuclear reactions is compared. The results show a bias in the models that favours the population of the high-spin states and that this can be produced by the overestimation of the spin width distribution. The reason for this study is to improve the models then used in the angular momentum calculation. 

    Moreover, the isomeric yield ratio measurement of twenty-one FFs is presented. The measurement was performed using the JYFLTRAP system at the University of Jyväskylä. The fission fragments were produced by the 32 MeV alpha-particle induced fission of 232Th. The analysis process, involving different identification and correction methods, and preliminary results are presented.

    List of papers
    1. Global comparison between experimentally measured isomeric yield ratios and nuclear model calculations
    Open this publication in new window or tab >>Global comparison between experimentally measured isomeric yield ratios and nuclear model calculations
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    2023 (English)In: European Physical Journal A, ISSN 1434-6001, E-ISSN 1434-601X, Vol. 59, no 12, article id 295Article in journal (Refereed) Published
    Abstract [en]

    The level density steers transition probabilities between different states in the decay and de-excitation of excited nuclei. Reliable level density modelling is, therefore, key in describing, e.g., de-excitation of fission fragments, with implications on neutron and gamma-rays multiplicities, and also manifested in the population of isomeric states. We test six currently used level density models and the spin distribution in the level density by comparing calculations with measured isomeric yield ratios. The model calculations are performed with the TALYS code and experimental data for nuclear reactions populating spin isomers are retrieved from the EXFOR database. On average, calculations are in agreement with measured data. However, we find that the population of the high-spin state in an isomeric pair is clearly favoured in all of the six studied level density models. Further studies are then performed on the three used phenomenological level density models, to investigate the significance of their effect. We find that a significant reduction of the spin width distribution improves the agreement between calculated and experimentally observed isomeric yield ratios. This result is independent of the incident particle in the nuclear reaction. The needed reduction of the spin width distribution to comply with empirical data has, e.g., implications for studies in angular momentum generation in fission using isomeric yield rations, calculations of anti-neutrino spectra from nuclear reactors, as well as neutron and gamma-ray multiplicities in nuclear reactor calculations.

    Place, publisher, year, edition, pages
    Springer, 2023
    National Category
    Subatomic Physics
    Identifiers
    urn:nbn:se:uu:diva-519501 (URN)10.1140/epja/s10050-023-01202-5 (DOI)001125578500001 ()
    Funder
    Swedish Research Council, 2020-04238Uppsala University
    Available from: 2024-01-10 Created: 2024-01-10 Last updated: 2024-03-04Bibliographically approved
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    SC_Licentiate_thesis
  • Jämterud, Rasmus
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Widell, Henrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Optimizing Digital Transformation: Strategies for Private Banking in the Age of Technology2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis delves into the digital transformation of private banking, emphasizing the challenge of balancing technology with the personalized service that high-net-worth clients expect. Employing frameworks like Relationship Marketing, the Technology Acceptance Model, and Customer Experience Management, it examines the integration and impact of digital tools on client relationships and operational efficiency in private banking. The research, informed by interviews with industry professionals, explores the adoption of digital practices, highlighting a trend towards operational efficiency yet revealing a gap in achieving the depth of personalization characteristic of private banking. The study concludes by exploring the future of digitalization in the sector, suggesting a strategic approach where technological advancements complement the foundational elements of private banking. This balanced integration is vital for maintaining the essence of bespoke advice and trust that defines the client-advisor bond in an increasingly digital financial landscape.

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  • Bevegård, Alice
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Herte, Jack
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Från mål till handling: En kvalitativ studie av svenska industriföretags arbete med SBT2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I samband med ökade förväntningar på hållbart företagande har fler företag valt att fastställa hållbarhetsmål som överensstämmer med vetenskapliga riktlinjer. Detta gäller inte minst inom industrisektorn, vars stora klimatavtryck har väckt debatt i media. Denna studie undersökte två svenska industriföretag tillvägagångssätt och utmaningar i arbetet med att uppnå sina Science Based Targets (SBT). Studien tillämpade en kvalitativ metod, där representanter från SKF och SSAB intervjuades om deras arbete för att nå SBT. Vidare utfördes en dataanalys av sekundärdata för att ge en nyanserad bild av företagens arbete med SBT. Studien utgick från teorin om organisationsförändring som behandlar företags tillvägagångssätt för att förändra verksamheten. För att kategorisera företagens förändringsprocess och utmaningar tillämpade studien Huong Has förändringsmodell. 

    Studien fann såväl skillnader som likheter i företagens tillvägagångssätt och utmaningar i arbetet med SBT. I synnerhet identifierades den påverkan som intressenters agerande har på förändringsprocessen. Effektiv kommunikation och samarbete mellan organisationer och aktörer framträdde därför som centralt för att minska företagens klimatavtryck. 

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    Bevegård & Herte- Från mål till handling
  • Nordin, Wilma
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Urtel Carlbom, Philip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hur samverkar varumärkesaktivism och kriskommunikation?: En kvalitativ studie av hur varumärkesaktivism och kriskommunikation kan samverka för att upprätthålla trovärdighet i händelse av kris2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Varumärkesaktivism är en allt mer uppmärksammad marknadsföringsstrategi som har utvecklats till följd av en turbulent och polariserad samtid med globala, regionala och lokala utmaningar. Den har gett upphov till sociopolitiska diskussioner och ökade krav från konsumenter gentemot företag. Vad som inte är helt klarlagt är vad som händer om ett varumärkesaktivistiskt företag drabbas av en kris och hur de kommunicerar för att upprätthålla sin trovärdighet. Studiens övergripande syfte är att analysera hur varumärkesaktivism och kriskommunikation kan samverka för att upprätthålla ett varumärkesaktivistiskt företags trovärdighet i händelse av kris. Uppsatsen strävar således efter att generera insikter om och konkretisera dynamiken mellan varumärkesaktivism och kriskommunikation. Studien tar avstamp i en kvalitativ innehållsanalys av den kommunikation som publicerats av havredrycksföretaget Oatly under den kris som uppstod till följd av att de tog emot en finansiell investering av investeringsbolaget Blackstone. Studien visar att varumärkesaktivistiska kommunikationsstrategier och kriskommunikation kan samverka med det gemensamma målet att upprätthålla trovärdighet. Sociopolitiska ställningstaganden i samband med en strävan efter samhällsförändring kan, genom att ta stöd i förtroendeingivande organisationer, användas och förstärkas genom att som företag upprätthålla en enhetlig och transparent kommunikation.  Därmed kan ytterligare indikationer ges inom den akademiska diskursen om varumärkesaktivism och kristeori samt hur de två teorierna samspelar med varandra. 

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  • Olsson, Filip
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Welander, Theodor
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kontroversiella frågor i klassrummet: Lärares perspektiv och utmaningar med Israel och Palestina i fokus2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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    Kontroversiella frågor i klassrummet: Lärares perspektiv och utmaningar med Israel och Palestina i fokus
  • Åström, Angelica
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Lohsar, Mahnoor
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    EU-undervisning på YouTube: Europeiska unionens inrikespolitiska respektive utrikespolitiska inramning och dess integration i kunskapsområdet nationell politik2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Digital undervisning har blivit alltmer vanligt i skolans värld vilket har många fördelar. Tillgängligt undervisningsmaterial, öppet för alla att ta del av, består bland annat av videor på YouTube. Däremot finns det inte mycket forskning kring lärare och undervisningsmaterial på sociala medier som YouTube då dessa tillvägagångsätt fortfarande är väldigt nya, med tanke på teknologins snabba utveckling. Denna studie ämnar ta reda på hur lärare framställer undervisningsinnehåll om EU, närmare bestämt om EU-undervisningen ges en inrikespolitisk eller utrikespolitisk inramning. Studien syftar även till att ta reda på hur EU integreras i undervisning om nationell politik. Materialet består av ett flertal videor uppladdade av tre olika lärare på YouTube vars undervisningsinnehåll analyseras. Undersökningen kommer fram till att lärare tar upp olika ämnesinnehåll kring EU och därför inramas det också på olika sätt när det kommer till inrikespolitiska och utrikespolitiska kännetecken. Denna studie kan bidra till att hjälpa lärare förstå hur de kan lägga upp undervisningen om EU med hjälp av YouTube som ett digitalt verktyg. Studien kan även ge blivande och erfarna lärare verktyg att ge undervisningen en inrikespolitisk inramning med rätt förutsättningar att främja en politisk deltagarkompetens på EU-nivå hos eleverna. 

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  • Jarnelid, Beatrix
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Ohlsson, William
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Lärares åsikter: navigering och hantering i klassrumsdynamiken: Elevers uppfattningar om lärares hantering av personliga politiska åsikter i samhällskunskapsundervisningen2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • Dellnäs, Julia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Utökade ansvarsbestämmelser i lagen om digitala tjänster– vad innebär de egentligen för onlinemarknadsplatser?2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    This paper reviews the responsibilities and liability of online marketplaces within the Digital Services Act (DSA) framework. The DSA, proposed by the European Union, represents a comprehensive legislative initiative to regulate digital platforms and intermediaries, with a particular emphasis on online marketplaces. Specifically, the focus of this paper is on the obligations imposed on online marketplaces, shedding light on the regulatory landscape governing their conduct and responsibilities. This paper aims to examine the implications of the extended responsibilities of online marketplaces under the DSA. The analysis explores potential changes in their levels of responsibility, obligations, and measures for handling user-generated content. Through this, the aim is to contribute to the debate on regulating digital platforms, shedding light on key aspects of online marketplace responsibilities. This is performed using a critical policy analysis methodology, examining the legal content of the DSA regulation, and analysing the practical consequences of its implementation, with a special focus on how the DSA ensures a responsible and sustainable retail environment and what the increased requirements mean for online marketplaces in practice.

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  • Niklasson, Christoffer
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Gullander, Elliott
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Från arbetsmarknad till individ: – En kvalitativ studie av skildringen av genus i samhällskunskapsböcker mellan 1970-20202024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • Stertman, Ragna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Joining NATO: A qualitative case study of Sweden’s autobiographical narrative 2024Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In May 2022 the Swedish government took the momentous decision to apply for membership in NATO, putting an end to what had constituted Sweden’s foreign and security policy identity for over half a century. In order to make sense of this historical shift and its entailing implications for Sweden’s identity in the international sphere, I turned to the literature on ontological security and autobiographical narratives. This literature indicated that states need to maintain a stable and continuous identity in order to remain ontologically secure. However, this kind of security can be maintained despite alterations that destabilize the state’s identity through modifications of the state’s autobiographical narrative. According to some scholarly work, policymakers activate parts of the narrative and deactivate others, in order to maintain continuity to the state’s autobiography and in continuation its identity. Thus, through a qualitative analysis of Sweden’s autobiographical narrative, this thesis makes use of and tests this underpinning logic. In line with previous research, the generated insights from the study suggest that Sweden’s autobiographical narrative manifests some continuity despite membership in NATO standing in stark contrast with the state’s identity. 

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  • Björnsby, Richard
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Hur möter Skolverket eleverna i klassrummet?: En undersökning av det nationella provet i samhällskunskap åk. 9 utifrån ett hållbarhetsperspektiv.2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • Kohberg, Anna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Sjögren, Tilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kontroversiella frågor i samhällskunskapsdidaktiska läromedel: En framställning av undervisningsmetoder i läromedel riktade till lärarstudenter2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • Cegrell, Victor
    et al.
    Sörsäter, Joel
    Struktur, relevans och effektivitet: En studie om läroboksanvändningen i samhällskunskap2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats syftar till att skapa kunskap om lärares användning av läroboken inom gymnasieämnet samhällskunskap för årskurs 1. Detta undersöks genom att analysera 57 lärares svar på en enkät som vi utformat. Uppsatsen kompletterar det nuvarande forskningsläget om läroboken och dess användning inom samhällskunskapen då den tidigare forskningen främst har en kvalitativ karaktär där den valda undersökningsmetoden har varit djupintervjuer.Uppsatsens analys består av fyra delar, där varje del behandlar en aspekt av lärarnas användning av läroboken. Aspekter som undersöks i uppsatsen är i vilken utsträckning som läroboken utgör ett undervisningsmoment på lektionerna, vilka ämnesområden från det centrala innehållet som lärarna väljer att använda lärobokens texter och övningsuppgifter inom samt orsaker till varför lärarna väljer att använda sig av läroboken i sin undervisning eller inte. För att kunna tolka lärarnas användning av läroboken inom de olika ämnesområdena appliceras Östmans kunskapsemfaser på resultaten.Resultaten visar att lärobokens texter används mer av lärarna i undervisningen än lärobokens övningsuppgifter, då 49% av lärarna använder lärobokens texter varje vecka eller oftare medan motsvarande andel för lärobokens övningsuppgifter är 21%. De ämnesområden där det är vanligast att lärarna använder sig av läroboken är mer begreppstunga områden som exempelvis demokrati och ekonomi. De ämnesområden där läroboken används sällan är källkritik, folkrätten samt grupper och individers identitet. I analysen tolkas lärarnas användning av läroboken i relation till ämnesområdena med hjälp av Östmans kunskapsemfaser, och vi sluter oss till att de områden där läroboken används ofta i huvudsak utgörs av kunskapsemfasen Den rätta förklaringen. Bland de orsaker som lärarna anger är viktigast för att använda läroboken är att den skapar struktur i undervisningen, något som vi i resultatet tolkar som att läroboken fungerar som ett stöd i planeringen av undervisningsmoment. Orsaker till att inte använda läroboken i undervisningen anser lärarna vara för att andra undervisningsmetoder upplevs fungera bättre. Resultatet utvecklar denna förklaring baserat på de resonemang som lärarna för i enkäten och konstaterar att när samhällskunskapslärarna väljer bort läroboken så är det troligen så på grund av att den saknar relevans och vardagsnära innehåll.

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  • Johansson, Rasmus
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Hyvärinen, Geir Felix
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Rättsstaten och dess principer i lärares undervisningsmaterial: En undersökning om lärares didaktiska val och elevers förutsättningar i Samhällskunskap 1b2024Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna studie är att undersöka lärares didaktiska val avseende undervisning om rättsstatens principer samt de rättsstatsprinciper som kommer till uttryck i deras undervisningsmaterial. Detta har bakgrund i frågans relevans i koppling till samhällskunskapsämnets syfte och innehåll, och till ett samhällstillstånd där frågan om rättsstatens utformning blivit alltmer aktuell. Studieobjektet är lärares undervisningsmaterial i samhällskunskap samt intervjusvar från lärare som undervisar i ämnet. Kunskapsobjektet är hur rättsstaten och dess principer manifesteras som ämnesinnehåll, samt hur lärare resonerar kring deras didaktiska val i moment där rättsstatens principer kan ingå. I studien har följande frågor avsatts att besvaras: ”Hur beskriver lärare sina didaktiska val i moment där rättsstatens principer kan ingå?” samt ”Hur beskrivs och används rättsstaten och dess principer i samhällskunskapslärares undervisningsmaterial?”.

    Studien har delats upp i två delstudier. I den första delstudien har åtta gymnasielärare i samhällskunskap intervjuats om deras didaktiska val i kursen Samhällskunskap 1b. Intervjusvaren har därefter analyserats utifrån en didaktisk analys. I den andra delstudien har ett urval av undervisningsmaterial samt läroböcker från de intervjuade lärarnas undervisning analyserats, för att undersöka hur rättsstaten och dess principer beskrivs i undervisningsmaterialen respektive läroböckerna.

    Delstudierna ger mångfasetterade resultat; rättsstatens vara eller inte vara ses olika betonade inom respondenternas material och didaktiska val. Trots undantag syns rättsstaten sällan behandlas på ett explicit och samlat sätt. Där rättsstatsprinciper formuleras på ett enhetligt och samlat sätt, görs detta dessutom främst utifrån en formell (och inte gängse akademisk) framställning av rättsstatsbegreppet inom undervisningsmaterialen. Dess kärnvärden framställs emellertid hos samtliga respondenters undervisningsmaterial i fragmenterade former, och ofta utan uttrycklig koppling till rättsstat. Rättsstaten och dess principers relevans går emellertid inte att förbise; liksom 2025 års kommande kursplan i Samhällskunskap 1b (version 1) betonar respondenterna att rättsstaten och dess principer är viktiga inom de ämnesområden där de kan tänkas ingå. Respondenternas olika betoningar och förhållanden till bland annat kursens centrala innehåll och deras anpassning till elevers olika möjligheter och svårigheter i klassrummet, har visat hur lärares didaktiska val spelar in i frågan om hur eller huruvida rättsstaten och dess principer tar plats i klassrummet. Även tidsbristen på detta annars innehållstäta ämne har belysts, vilket också ger insikti denna fråga och lärarnas didaktiska val. Även om dessa fragmenterade framställningar inom undervisningsmaterialen kan ses försvåra elevens inlärning av och förståelse för rättsstatens betydelse i demokratin, visar undervisningsmaterialen samt respondenternas berättelser på rättsstatens relevans inom kursen Samhällskunskap 1b:s nuvarande utformning.

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  • Ahde, August
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Byhlin, Christoffer
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Att göra som och vara en medborgare: En kvalitativ intervjustudie om en samhällsdidaktisk utmaning2023Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • Fåhraeus, David
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Reichel, Jane
    Department of Law, Stockholm University; Stockholm , Sweden.
    Slokenberga, Santa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    The European Health Data Space: Challenges and Opportunities2024Report (Other academic)
    Abstract [en]

    In her 2020 State of the Union address, the European Commission President Ursula von der Leyen announced a new legislative proposal to create a European Health Data Space. Its aim is to make electronic health data accessible in order to support healthcare delivery, health research, innovation, effective policymaking and regulation, and personalised medicine. This European Policy Analysis examines the Commission’s proposal and its implications for patients, healthcare providers, market actors and national administrations.

    The analysis shows that the Commission’s Proposal has significant potential benefits for a wide range of stakeholders. However, concerns still remain regarding aspects such as the empowerment of individuals in relation to their data, adjustments that will need to be made by the healthcare sector, incentives for innovation, and trust in EU governance. At the time of writing, the European Parliament and the Council have adopted their negotiating positions. However, a number of changes are likely to be introduced before the Commission’s Proposal is agreed and can be implemented in the Member States. 

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  • Beretta, Chiara
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics.
    Svensson, Elina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics. Department of Neuroinflammation, UCL Queen Square Institute of Neurology, 1 Wakefield Street, WC1N 1PJ London, United Kingdom of Great Britain and Northern Ireland.
    Dakhel, Abdulkhalek
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics.
    Zyśk, Marlena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics.
    Hanrieder, J.
    Sehlin, Dag
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics.
    Michno, Wojciech
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Erlandsson, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Molecular Geriatrics.
    Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms2024In: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 128, article id 103916Article in journal (Refereed)
    Abstract [en]

    Alzheimer's disease (AD) is a neurodegenerative disorder that develops over decades. Glial cells, including astrocytes are tightly connected to the AD pathogenesis, but their impact on disease progression is still unclear. Our previous data show that astrocytes take up large amounts of aggregated amyloid-beta (Aβ) but are unable to successfully degrade the material, which is instead stored intracellularly. The aim of the present study was to analyze the astrocytic Aβ deposits composition in detail in order to understand their role in AD propagation. For this purpose, human induced pluripotent cell (hiPSC)-derived astrocytes were exposed to sonicated Aβ42 fibrils and magnetic beads. Live cell imaging and immunocytochemistry confirmed that the ingested Aβ aggregates and beads were transported to the same lysosomal compartments in the perinuclear region, which allowed us to successfully isolate the Aβ deposits from the astrocytes. Using a battery of experimental techniques, including mass spectrometry, western blot, ELISA and electron microscopy we demonstrate that human astrocytes truncate and pack the Aβ aggregates in a way that makes them highly resistant. Moreover, the astrocytes release specifically truncated forms of Aβ via different routes and thereby expose neighboring cells to pathogenic proteins. Taken together, our study establishes a role for astrocytes in mediating Aβ pathology, which could be of relevance for identifying novel treatment targets for AD.

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  • Johansson, Hampus
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ribberheim, Leo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Priseffekter vid indexförändringar: En studie om OMXS302024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • van Bremen, Demy
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Tao, Zui
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Reserveringar för kreditförluster under olika konjunkturlägen: dess påverkan på bankens aktieavkastning2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Vi syftar med denna studie till fördjupa förståelsen för sambandet mellan redovisning av kreditförluster, konjunkturläge och aktieavkastning inom banksektorn genom att finna svar på följande frågeställning: “Hur påverkas bankers aktieavkastning av reserveringar för kreditförluster i relation till konjunkturläget?” 

    Marknadsreaktioner på kapitalmarknaden uppmätts genom att beräkna kumulativ avvikelse avkastning vid 4 olika eventfönster för publicering av kvartalsrapporter vid 18 olika tillfällen under ett tidsintervall från Q1:2019 till Q2:2023. Detta eftersom förändringar i reserveringar för kreditförluster först tillkännages till allmänheten i kvartalsrapporten. Därefter genomförs en multipel regressionsanalys med interaktionseffekter på den beroende variabeln CAR för att undersöka om reserveringar för kreditförluster påverkar bankers aktieavkastning under olika konjunkturläge.

    Med resultatet från eventstudien och regressionsanalysen kan vi dra slutsatsen att reaktionerna på kapitalmarknaden som observerades som effekt av publicering av kvartalsrapporter till största del inte kan förklaras av förändringar i reserveringar för kreditförluster. 

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    Reserveringar för kreditförluster under olika konjunkturlägen och dess påverkan på bankens aktieavkastning
  • Public defence: 2024-04-12 09:15 Polhemsalen, 10134, Uppsala
    Nüssgen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Electricity. Technische Hochschule Köln.
    Intelligent Data and Potential Analysis in the Mechatronic Product Development2024Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis explores the imperative of intelligent data and potential analysis in the realm of mechatronic product development. The persistent challenges of synchronization and efficiency underscore the need for advanced methodologies. Leveraging the substantial advancements in Artificial Intelligence (AI), particularly in generative AI, presents unprecedented opportunities. However, significant challenges, especially regarding robustness and trustworthiness, remain unaddressed.

    In response to this critical need, a comprehensive methodology is introduced, examining the entire development process through the illustrative V-Model and striving to establish a robust AI landscape. The methodology explores acquiring suitable and efficient knowledge, along with methodical implementation, addressing diverse requirements for accuracy at various stages of development. 

    As the landscape of mechatronic product development evolves, integrating intelligent data and harnessing the power of AI not only addresses current challenges but also positions organizations for greater innovation and competitiveness in the dynamic market landscape.

    List of papers
    1. Leveraging Robust Artificial Intelligence for Mechatronic Product Development: A Literature Review
    Open this publication in new window or tab >>Leveraging Robust Artificial Intelligence for Mechatronic Product Development: A Literature Review
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    2024 (English)In: International Journal of Intelligence Science, ISSN 2163-0283, E-ISSN 2163-0356, Vol. 14, no 01, p. 1-21Article, review/survey (Refereed) Published
    Abstract [en]

    Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.

    Place, publisher, year, edition, pages
    Scientific Research Publishing, 2024
    Keywords
    Artificial Intelligence, Mechatronic Product Development, Knowledge Management, Data Analysis, Optimization, Human Experts, Decision-Making Processes, V-Cycle
    National Category
    Production Engineering, Human Work Science and Ergonomics Software Engineering Other Mechanical Engineering
    Identifiers
    urn:nbn:se:uu:diva-523604 (URN)10.4236/ijis.2024.141001 (DOI)
    Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-21Bibliographically approved
    2. Intelligent analysis of components with regard to significant features for subsequent classification
    Open this publication in new window or tab >>Intelligent analysis of components with regard to significant features for subsequent classification
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    2023 (English)Conference paper, Published paper (Other academic)
    Keywords
    Knowledge Explosion, Data Mining, Machine Learning, Artificial Intelligence, Data Interpretation, Raytracing, Classification
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-495655 (URN)
    Conference
    23rd Stuttgart International Symposium, Automotive and Engine Technology, 4-5 July 2023, Stuttgart
    Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2024-02-21
    3. Intelligent Component Manufacturability Testing in Virtual Product Development
    Open this publication in new window or tab >>Intelligent Component Manufacturability Testing in Virtual Product Development
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    2023 (German)Conference paper, Oral presentation with published abstract (Other academic)
    Place, publisher, year, edition, pages
    NAFEMS: International Association for the Engineering Modelling, Analysis and Simulation Community, 2023
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-523605 (URN)
    Conference
    Artificial Intelligence und Machine Learning in der CAE-basierten Simulation, München, 23-24 Oktober, 2023
    Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-21Bibliographically approved
    4. Robustness and Sensitivity of Artificial Neural Networks for Mechatronic Product Development
    Open this publication in new window or tab >>Robustness and Sensitivity of Artificial Neural Networks for Mechatronic Product Development
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    2023 (English)Conference paper, Oral presentation with published abstract (Refereed)
    Abstract [en]

    In the fast-paced world of automotive development, the need for effective information exchange between different domains is becoming increasingly critical. The parallelized and agile nature of development demands early and frequent access to accurate information across various departments. However, deviations and uncertainties in data can lead to costly disruptions in the development process. Artificial intelligence based prediction models offer a potential solution by providing estimates based on previous projects or analyzed products, even in the early stages of development. While rough estimates may suffice initially, it is important to understand the accuracy of such predictions. This study therefore aims to evaluate the performance characteristics of different uncertainty analysis methods and assess their applicability in agile automotive development processes. By considering the specific requirements and constraints of each method, a decision tree is proposed to recommend suitable and situation-appropriate methods for performing uncertainty analyses in network prediction. The goal is to enhance data exchange between departments, mitigate disruptions, and ensure informed decision-making throughout the development process.

    National Category
    Other Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-510741 (URN)
    Conference
    Automotive meets Electronics
    Available from: 2023-09-02 Created: 2023-09-02 Last updated: 2024-02-21
    5. Integration of Vulnerable Road Users Behavior into a Virtual Test Environment for Highly Automated Mobility Systems
    Open this publication in new window or tab >>Integration of Vulnerable Road Users Behavior into a Virtual Test Environment for Highly Automated Mobility Systems
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    2022 (English)Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Esslingen: , 2022
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-487152 (URN)
    Conference
    Future Mobility 2022
    Available from: 2022-10-25 Created: 2022-10-25 Last updated: 2024-02-21Bibliographically approved
    6. Methodical Approach to Integrate Human Movement Diversity in Real-Time into a Virtual Test Field for Highly Automated Vehicle Systems
    Open this publication in new window or tab >>Methodical Approach to Integrate Human Movement Diversity in Real-Time into a Virtual Test Field for Highly Automated Vehicle Systems
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    2022 (English)In: Journal of Transportation Technologies, ISSN 2160-0473, E-ISSN 2160-0481, Vol. 12, no 3, p. 296-309Article in journal (Refereed) Published
    Abstract [en]

    Recently, virtual realities and simulations play important roles in the development of automated driving functionalities. By an appropriate abstraction, they help to design, investigate and communicate real traffic scenario complexity. Especially, for edge cases investigations of interactions between vulnerable road users (VRU) and highly automated driving functions, valid virtual models are essential for the quality of results. The aim of this study is to measure, process and integrate real human movement behaviour into a virtual test environment for highly automated vehicle functionalities. The overall system consists of a georeferenced virtual city model and a vehicle dynamics model, including probabilistic sensor descriptions. By motion capture hardware, real humanoid behaviour is applied to a virtual human avatar in the test environment. Through retargeting methods, which enable the independency of avatar and person under test (PuT) dimensions, the virtual avatar diversity is increased. To verify the biomechanical behaviour of the virtual avatars, a qualitative study is performed, which funds on a representative movement sequence. The results confirm the functionality of the used methodology and enable PuT independence control of the virtual avatars in real-time.

    Place, publisher, year, edition, pages
    Scientific Research Publishing, 2022
    Keywords
    Advanced Driver Assistance Systems/Automated Driving (ADAS/AD), Autonomous Mobility, Virtual Testing, Motion Capture
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science
    Identifiers
    urn:nbn:se:uu:diva-487151 (URN)10.4236/jtts.2022.123018 (DOI)
    Available from: 2022-10-25 Created: 2022-10-25 Last updated: 2024-02-21Bibliographically approved
    7. Data Flow Management Requirements for Virtual Testing of Highly Automated Vehicles
    Open this publication in new window or tab >>Data Flow Management Requirements for Virtual Testing of Highly Automated Vehicles
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    2022 (English)Conference paper, Published paper (Refereed)
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-487179 (URN)
    Conference
    AVL German Simulation Conference, 27-28 September 2022, Regensburg, Germany
    Available from: 2022-10-25 Created: 2022-10-25 Last updated: 2024-02-21Bibliographically approved
    8. Stereoscopic Camera-Sensor Model for the Development of Highly Automated Driving Functions within a Virtual Test Environment
    Open this publication in new window or tab >>Stereoscopic Camera-Sensor Model for the Development of Highly Automated Driving Functions within a Virtual Test Environment
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    2023 (English)In: Journal of Transportation Technologies, ISSN 2160-0473, E-ISSN 2160-0481, Vol. 13, no 1, p. 87-114Article in journal (Refereed) Published
    Abstract [en]

    The need for efficient and reproducible development processes for sensor and perception systems is growing with their increased use in modern vehicles. Such processes can be achieved by using virtual test environments and virtual sensor models. In the context of this, the present paper documents the development of a sensor model for depth estimation of virtual three-dimensional scenarios. For this purpose, the geometric and algorithmic principles of stereoscopic camera systems are recreated in a virtual form. The model is implemented as a subroutine in the Epic Games Unreal Engine, which is one of the most common Game Engines. Its architecture consists of several independent procedures that enable a local depth estimation, but also a reconstruction of a whole three-dimensional scenery. In addition, a separate programme for calibrating the model is presented. In addition to the basic principles, the architecture and the implementation, this work also documents the evaluation of the model created. It is shown that the model meets specifically defined requirements for real-time capability and the accuracy of the evaluation. Thus, it is suitable for the virtual testing of common algorithms and highly automated driving functions.

    Place, publisher, year, edition, pages
    Scientific Research Publishing, 2023
    Keywords
    Sensor Model, Virtual Test Environment, Stereoscopic Camera, Unreal Engine, OpenCV, ADAS/AD
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-495643 (URN)10.4236/jtts.2023.131005 (DOI)
    Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2024-02-21Bibliographically approved
    9. Development and Analysis of a Detail Model for Steer-by-Wire Systems
    Open this publication in new window or tab >>Development and Analysis of a Detail Model for Steer-by-Wire Systems
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    2023 (English)In: IEEE Access, E-ISSN 2169-3536, Vol. 11, p. 7229-7236Article in journal (Refereed) Published
    Abstract [en]

    Steer-by-wire systems represent a key technology for highly automated and autonomous driving. In this context, robust steering control is a fundamental precondition for automated vehicle lateral control. However, there is a need for improvement due to degrees of freedom, signal delays, and nonlinear characteristics of the plant which are unconsidered in the design models for the design of current steering controls. To be able to design an extremely robust steering control, suitable optimal models of a steer-by-wire system are required. Therefore, this paper presents an innovative nonlinear detail model of a steer-by-wire system. The detail model represents all characteristics of a real steer-by-wire system. In the context of a dominance analysis of the detail model, all dominant characteristics of a steer-by-wire system, including parameter dependencies, are identified. Through model reduction, a reduced model of the steer-by-wire system is then developed that can be used for a subsequent robust control design. Furthermore, this paper compares the steer-by-wire system with a conventional electromechanical power steering and shows similarities as well as differences.

    Place, publisher, year, edition, pages
    IEEE, 2023
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-495645 (URN)10.1109/access.2023.3238107 (DOI)000922817400001 ()
    Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2024-02-21Bibliographically approved
    10. Design of a Model-Based Optimal Multivariable Control for the Individual Wheel Slip of a Two-Track Vehicle
    Open this publication in new window or tab >>Design of a Model-Based Optimal Multivariable Control for the Individual Wheel Slip of a Two-Track Vehicle
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    2023 (English)Conference paper, Published paper (Other academic)
    National Category
    Vehicle Engineering Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-495652 (URN)
    Conference
    23rd Stuttgart International Symposium, 4-5 July 2023, Stuttgart
    Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2024-02-21
    11. Methodical Data Collection for Light Electric Vehicles to validate Simulation Models and fit AI-based Driver Assistance Systems
    Open this publication in new window or tab >>Methodical Data Collection for Light Electric Vehicles to validate Simulation Models and fit AI-based Driver Assistance Systems
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    2022 (English)Conference paper, Published paper (Other academic)
    Keywords
    Vehicle dynamics, Light electric vehicle, Tricycle, Data logger system, Data collection, Driver assistance systems
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-487181 (URN)
    Conference
    Future Mobility
    Available from: 2022-10-25 Created: 2022-10-25 Last updated: 2024-02-21Bibliographically approved
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  • Vadi Dris, Sam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Development of ultra-sensitive immunoassay on Gyrolab microfluidic platform using Binding Oligo Ladder Detection: Enhancing Gyrolab biomarker assays using Exazym®2024Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Immunoassays are widely used for detection of antigens in a wide range of applications including assays in pharmaceutical development. Immunoassays are continuously improved in many aspects including automatization, miniaturization and extending the dynamic range. The need to measure low abundance molecules are challenging and the need to improve the sensitivity is desired. The Gyrolab technology is a miniaturized immunoassay performed in an automated system covering a broad concentration range. In order to  extend the sensitivity, the technology is combined with Binding Oligo Ladder Detection (BOLD) amplification. The technology behind BOLD or Exazym

    ® utilizes a DNA primer, a polymerase, and a template (RNA) to generate a ladder-like modified DNA strand. Antibodies with affinity for the polymerized DNA:RNA hybrid strand (duplex) conjugated with reporter molecules are introduced to the system, resulting in an increased number of signal-generating molecules associated with each bound analyte molecule. In this thesis, the development of an ultra-sensitive immunoassay is pursued by applying Exazym

    ® add-on reagents to the Gyrolab platform, comparing performance with the standard Gyrolab sandwich assay and other commercially available high-performing TNF-α assays. The work includes characterization of a wide range of reaction variables involved in the BOLD signal amplification process including hybridization, polymerization, and detection of a synthetic oligonucleotide. The breakthrough involves the introduction of Allophycocyanin (APC) as a fluorescent conjugate, significantly improving sensitivity and signal-to-noise ratios. The BOLD amplified sensitivity for the TNF-α assay approaches levels seen in ultra-sensitive biomarker assays like Erenna

    ® and Simoa®. Exazym® technology on the Gyrolab platform allows highly sensitive biomarker assays with minimal sample volume and a 1–2-hour run-time. The study marks substantial progress in achieving ultra-sensitive biomarker assays on the Gyrolab platform through BOLD signal amplification. The use of APC-conjugated detection reagents holds promise for future optimization studies.

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  • Public defence: 2024-04-10 09:15 Sal IX, Uppsala
    Bärkås, Annika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group.
    Patients’ Access to Their Mental Health Records: Understanding Policy, Access, and Patient Experiences2024Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    ORA is the concept of patients' access to clinical information, which has become more widespread worldwide. When patients are provided online record access (ORA) to their health records, concerns have been raised by healthcare professionals, especially when it comes to patients with mental health diagnoses. In the general population, positive aspects appear to outweigh the negative, yet limited research has so far explored the impact of ORA in mental healthcare. 

    The overall aim of this thesis was to explore how patients experience ORA in mental healthcare through four studies: 1) a literature review aimed to explore the current literature on the experiences of ORA among mental healthcare patients, care partners, and healthcare professionals, 2) a document analysis combined with key stakeholder email interviews that aimed to explore to what extent ORA in mental healthcare has been implemented in Sweden including national and local policy regulations, 3) an online patient survey study aimed to understand mental healthcare patients' experiences with ORA in Sweden, Estonia, Finland, and Norway, and 4) an online patient survey study aimed to understand if and how patients with mental health conditions experiences of ORA differs from patients in other healthcare settings. 

    More patients reported positive experiences with ORA in mental healthcare than negative experiences. Common benefits of ORA included, among others, a greater sense of control over their care, improved understanding of their mental health diagnosis, and better adherence to appointments. Despite patients' predominant positive experiences, only 17 out of 21 regions in Sweden offered ORA in mental healthcare in 2021. Additionally, many patients experienced errors and omissions and felt offended by the content of their health records. Mental healthcare patients experienced this at a higher rate than patients in other healthcare settings.

    In conclusion, mental healthcare patients have higher rates of negative experiences of ORA compared to patients in other healthcare settings. However, patients' experiences of ORA are still predominantly positive among both patient groups. Yet, in 2021, only 17 regions offered patients ORA in mental healthcare. Denying mental healthcare patients ORA to protect them from negative experiences could instead increase stigma in this patient group.

    List of papers
    1. Sharing Clinical Notes and Electronic Health Records With People Affected by Mental Health Conditions: Scoping Review
    Open this publication in new window or tab >>Sharing Clinical Notes and Electronic Health Records With People Affected by Mental Health Conditions: Scoping Review
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    2021 (English)In: JMIR Mental Health, E-ISSN 2368-7959, Vol. 8, no 12, article id e34170Article in journal (Refereed) Published
    Abstract [en]

    Background: Electronic health records (EHRs) are increasingly implemented internationally, whereas digital sharing of EHRs with service users (SUs) is a relatively new practice. Studies of patient-accessible EHRs (PAEHRs)-often referred to as open notes-have revealed promising results within general medicine settings. However, studies carried out in mental health care (MHC) settings highlight several ethical and practical challenges that require further exploration.

    Objective: This scoping review aims to map available evidence on PAEHRs in MHC. We seek to relate findings with research from other health contexts, to compare different stakeholders' perspectives, expectations, actual experiences with PAEHRs, and identify potential research gaps.

    Methods: A systematic scoping review was performed using 6 electronic databases. Studies that focused on the digital sharing of clinical notes or EHRs with people affected by mental health conditions up to September 2021 were included. The Mixed Methods Appraisal Tool was used to assess the quality of the studies. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Extension for Scoping Reviews guided narrative synthesis and reporting of findings.

    Results: Of the 1034 papers screened, 31 were included in this review. The studies used mostly qualitative methods or surveys and were predominantly published after 2018 in the United States. PAEHRs were examined in outpatient (n=29) and inpatient settings (n=11), and a third of all research was conducted in Veterans Affairs Mental Health. Narrative synthesis allowed the integration of findings according to the different stakeholders. First, SUs reported mainly positive experiences with PAEHRs, such as increased trust in their clinician, health literacy, and empowerment. Negative experiences were related to inaccurate notes, disrespectful language use, or uncovering of undiscussed diagnoses. Second, for health care professionals, concerns outweigh the benefits of sharing EHRs, including an increased clinical burden owing to more documentation efforts and possible harm triggered by reading the notes. Third, care partners gained a better understanding of their family members' mental problems and were able to better support them when they had access to their EHR. Finally, policy stakeholders and experts addressed ethical challenges and recommended the development of guidelines and trainings to better prepare both clinicians and SUs on how to write and read notes.

    Conclusions: PAEHRs in MHC may strengthen user involvement, patients' autonomy, and shift medical treatment to a coproduced process. Acceptance issues among health care professionals align with the findings from general health settings. However, the corpus of evidence on digital sharing of EHRs with people affected by mental health conditions is limited. Above all, further research is needed to examine the clinical effectiveness, efficiency, and implementation of this sociotechnical intervention.

    Place, publisher, year, edition, pages
    JMIR Publications, 2021
    Keywords
    electronic health records, open notes, psychiatry, mental health, user involvement, patient advocacy, patient portal
    National Category
    Psychiatry Other Medical Sciences not elsewhere specified
    Research subject
    Medical Informatics; Psychology
    Identifiers
    urn:nbn:se:uu:diva-462043 (URN)10.2196/34170 (DOI)000739100300011 ()34904956 (PubMedID)
    Projects
    NORDeHEALTHBeyond Implementation of eHealth
    Funder
    NordForsk, 100477Forte, Swedish Research Council for Health, Working Life and Welfare, 2020-01229
    Available from: 2021-12-19 Created: 2021-12-19 Last updated: 2024-02-20Bibliographically approved
    2. Patients’ Access to Their Psychiatric Notes: Current Policies and Practices in Sweden
    Open this publication in new window or tab >>Patients’ Access to Their Psychiatric Notes: Current Policies and Practices in Sweden
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    2021 (English)In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 18, no 17, article id 9140Article in journal (Refereed) Published
    Abstract [en]

    Patients’ access to electronic health records (EHRs) is debated worldwide, and access to psychiatry records is even more criticized. There is a nationwide service in Sweden which offers all citizens the opportunity to read their EHR, including clinical notes. This study aims to explore Swedish national and local policy regulations regarding patients’ access to their psychiatric notes and describe to what extent patients currently are offered access to them. The rationale behind the study is that current policies and current practices may differ between the 21 self-governing regions, although there is a national regulation. We gathered web-based information from policy documents and regulations from each region’s website. We also conducted key stakeholder interviews with respondents from the regions and cross-regional private care providers, using a qualitative approach. The results show that 17 of 21 regions share psychiatric notes with patients, where forensic psychiatric care was the most excluded psychiatric care setting. All private care providers reported that they mainly follow the regions’ guidelines. Our findings show that regional differences concerning sharing psychiatric notes persist, despite Swedish regulations and a national policy that stipulates equal care for everyone. The differences, however, appear to have decreased over time, and we report evidence that the regions are moving toward increased transparency for psychiatry patients.

    Place, publisher, year, edition, pages
    MDPI, 2021
    Keywords
    mental health, psychiatry, psychiatric record, psychiatric notes, patient accessible electronic health record, PAEHR, open notes, policies
    National Category
    Health Care Service and Management, Health Policy and Services and Health Economy
    Research subject
    Medical Informatics
    Identifiers
    urn:nbn:se:uu:diva-452386 (URN)10.3390/ijerph18179140 (DOI)000694051800001 ()34501730 (PubMedID)
    Projects
    NORDeHEALTH
    Funder
    NordForsk, 100477
    Available from: 2021-09-06 Created: 2021-09-06 Last updated: 2024-02-20Bibliographically approved
    3. Experiences from Patients in Mental Healthcare Accessing their Electronic Health Records: Results from a Cross-National Survey in Estonia, Finland, Norway, and Sweden
    Open this publication in new window or tab >>Experiences from Patients in Mental Healthcare Accessing their Electronic Health Records: Results from a Cross-National Survey in Estonia, Finland, Norway, and Sweden
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Health Sciences
    Research subject
    Medical Informatics
    Identifiers
    urn:nbn:se:uu:diva-522716 (URN)
    Available from: 2024-02-08 Created: 2024-02-08 Last updated: 2024-02-20
    4. Errors, Omissions, and Offenses in the Health Record of Mental Health Care Patients: Results from a Nationwide Survey in Sweden
    Open this publication in new window or tab >>Errors, Omissions, and Offenses in the Health Record of Mental Health Care Patients: Results from a Nationwide Survey in Sweden
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    2023 (English)In: Journal of Medical Internet Research, E-ISSN 1438-8871, Vol. 25Article in journal (Refereed) Published
    Abstract [en]

    Background: Previous research reports that patients with mental health conditions experience benefits, for example, increased empowerment and validation, from reading their patient-accessible electronic health records (PAEHRs). In mental health care (MHC), PAEHRs remain controversial, as health care professionals are concerned that patients may feel worried or offended by the content of the notes. Moreover, existing research has focused on specific mental health diagnoses, excluding the larger PAEHR userbase with experience in MHC. Objective: The objective of this study is to establish if and how the experiences of patients with and those without MHC differ in using their PAEHRs by (1) comparing patient characteristics and differences in using the national patient portal between the 2 groups and (2) establishing group differences in the prevalence of negative experiences, for example, rates of errors, omissions, and offenses between the 2 groups. Methods: Our analysis was performed on data from an online patient survey distributed through the Swedish national patient portal as part of our international research project, NORDeHEALTH. The respondents were patient users of the national patient portal 1177, aged 15 years or older, and categorized either as those with MHC experience or with any other health care experience (nonmental health care [non-MHC]). Patient characteristics such as gender, age, education, employment, and health status were gathered. Portal use characteristics included frequency of access, encouragement to read the record, and instances of positive and negative experiences. Negative experiences were further explored through rates of error, omission, and offense. The data were summarized through descriptive statistics. Group differences were analyzed through Pearson chi-square. Results: Of the total sample (N=12,334), MHC respondents (n=3131) experienced errors (1586/3131, 50.65%, and non-MHC 3311/9203, 35.98%), omissions (1089/3131, 34.78%, and non-MHC 2427/9203, 26.37%) and offenses (1183/3131, 37.78%, and non-MHC 1616/9203, 17.56%) in the electronic health record at a higher rate than non-MHC respondents (n=9203). Respondents reported that the identified error (MHC 795/3131, 50.13%, and non-MHC 1366/9203, 41.26%) and omission (MHC 622/3131, 57.12%, and non-MHC 1329/9203, 54.76%) were “very important,” but most did nothing to correct them (MHC 792/3131, 41.29%, and non-MHC 1838/9203, 42.17%). Most of the respondents identified as women in both groups. Conclusions: About 1 in 2 MHC patients identified an error in the record, and about 1 in 3 identified an omission, both at a much higher rate than in the non-MHC group. Patients with MHC also felt offended by the content of the notes more commonly (1 in 3 vs 1 in 6). These findings validate some of the worries expressed by health care professionals about providing patients with MHC with PAEHRs and highlight challenges with the documentation quality in the records.

    Keywords
    electronic health records, EHR, mental health, mental health care, national survey, online records access, open notes, ORA, patient-accessible electronic health record, PAEHR, patients, user experiences
    National Category
    Health Care Service and Management, Health Policy and Services and Health Economy
    Research subject
    Medical Informatics
    Identifiers
    urn:nbn:se:uu:diva-515506 (URN)10.2196/47841 (DOI)
    Funder
    NordForsk, 100477
    Available from: 2023-11-03 Created: 2023-11-03 Last updated: 2024-02-20
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  • Adam, Lina N.
    et al.
    Univ Zakho, Coll Sci, Dept Biol, Duhok, Kurdistan Regio, Iraq..
    Al-Habib, Omar A. M.
    Univ Nawroz, Coll Sci, Dept Biol, Duhok, Kurdistan Regio, Iraq..
    Oraha, Ashur Y.
    Univ Duhok, Coll Med, Dept Cardiothorac & Vasc Surg, Duhok, Kurdistan Regio, Iraq..
    Shekha, Mudhir S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Salahaddin Univ Erbil, Coll Sci, Dept Biol, Erbil, Kurdistan Regio, Iraq..
    Genetic and clinical study of myeloperoxidase's association with coronary artery disease2024In: EGYPTIAN HEART JOURNAL, ISSN 1110-2608, Vol. 76, no 1, article id 27Article in journal (Refereed)
    Abstract [en]

    BackgroundUnraveling myeloperoxidase's (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies.ResultsCAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphatase, creatinine, and troponin levels, showed significant variations. Moreover, CAD patients had lower red cell distribution width (RDW%) and mean platelet volume (MPV) than controls. Serum MPO levels did not differ significantly between CAD patients and controls, and no correlation was found with other clinical parameters except for glucose, creatinine, and total bilirubin.ConclusionsThe data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD.Trial registration: 15092021-9-12. Registered 15 September 2021.ConclusionsThe data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD.Trial registration: 15092021-9-12. Registered 15 September 2021.

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  • Östling, Emma
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sigg, Sanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Digitala produktpass i modeindustrin: Företags förberedelse, utmaningar ochmöjligheter med framtida EU-förordning2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Digitala produktpasset (DPP) har föreslagits i en kommande EU-förordning och planeras attomfatta produkter i textilindustrin för att främja ökad spårbarhet, transparens och cirkulärekonomi. Med tanke på modeindustrins begränsade digitala kompetens, synlighet ivärdekedjan samt omfattningen av små-medelstora företag kan övergången till ett digitaltproduktpass innebära stora utmaningar. Studien syftar till att analysera och utvärderamodeföretags förutsättningar inför anpassningen till en cirkulär ekonomi och sättas i relationtill framtida DPP-regleringen. Teorier inom Sustainable Supply Chain Management ochcirkulär ekonomi används som grundläggande referensramar. Insamling av sekundärdata iform av årsredovisningar, hemsidor, nyhetsartiklar och en föreläsning samt intervjuer från tremodeföretag och tre ämnesexperter har genomförts. Resultatet antyder att modeföretagen inteuppnår spårbarhet i alla led och har minimala cirkulära initiativ, vilket gör en omställning tillett digitalt produktpass svåranpassad. Möjligheter och utmaningar som är identifieradehandlar om att samarbeta med leverantörer, samla och strukturera information frånproduktlivscykeln och engagera sig i cirkulära initiativ som är lönsamma.

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    fulltext
  • Keshavarz, Mahmoud
    Malmö högskola, Fakulteten för kultur och samhälle (KS), Institutionen för konst, kultur och kommunikation (K3).
    Uncræft: "The Unqualified", "The Illegal", and The Making Practices of Roma2014In: Asylstafetten hantverk crafts /  politik politics / [ed] Mahmoud Keshavarz;Maria Svensson, Malmö: Studio Malmö , 2014, p. 14-26Chapter in book (Other (popular science, discussion, etc.))
    Abstract [en]

    In July 2013, Malmö, Sweden, a group of asylum seekers and undocumented migrants initiated a march from Malmö to Stockholm called Asylstafetten. The marchers demanded that their stories of migration, asylum and undocumentedness be heard and transferred into action. Many activities were organised for the duration of the 34 day-long march including the crafting workshops. Through essays and conversations with participants of the march, this publication portrays multiple narratives about the workshops; the spaces they occupied, the practices and ideas they generated as well as their political potential to come. More Info: This text is part of a collaborative book project inspired by a series of crafting workshops held during Asylstafetten - a 34 day-long walking march from Malmö to Stockholm, Sweden during Summer 2013.

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  • Lafta, Muataz S.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Mwinyi, Jessica
    Uppsala University, WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Affatato, Oreste
    Uppsala University, WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Rukh, Gull
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Dang, Junhua
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Andersson, Gerhard
    Linköping Univ, Dept Behav Sci & Learning, Linköping, Sweden.;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Schiöth, Helgi B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Functional Pharmacology and Neuroscience.
    Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology2024In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 18, article id 1340108Article, review/survey (Refereed)
    Abstract [en]

    Increased knowledge about sex differences is important for development of individualized treatments against many diseases as well as understanding behavioral and pathological differences. This review summarizes sex chromosome effects on gene expression, epigenetics, and hormones in relation to the brain. We explore neuroanatomy, neurochemistry, cognition, and brain pathology aiming to explain the current state of the art. While some domains exhibit strong differences, others reveal subtle differences whose overall significance warrants clarification. We hope that the current review increases awareness and serves as a basis for the planning of future studies that consider both sexes equally regarding similarities and differences.

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  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Natl Ctr Nucl Res, PL-02093 Warsaw, Poland.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zu, J.
    State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China;State Key Lab Particle Detect & Elect, Hefei 230026, Peoples R China;Univ Sci & Technol China, Hefei 230026, Peoples R China.
    Determination of Spin-Parity Quantum Numbers for the Narrow Structure near the p¯Λ Threshold in e+e→pK−¯Λ+c.c.2023In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 131, no 15, article id 151901Article in journal (Refereed)
    Abstract [en]

    A narrow structure in the p¯Λ system near the mass threshold, named as X(2085), is observed in the process e+e→pK−¯Λ with a statistical significance greater than 20σ. Its spin and parity are determined for the first time to be JP=1+ in an amplitude analysis, with a statistical significance greater than 5σ over other quantum numbers (0,1 and 2+). The pole positions of X(2085) are measured to be Mpole=(2084+4−2±9)  MeV and Γpole=(58+4−3±25)  MeV, where the first uncertainties are statistical and the second ones are systematic. The analysis is based on the study of the process e+e→pK−¯Λ and uses the data samples collected with the BESIII detector at the center-of-mass energies √s=4.008, 4.178, 4.226, 4.258, 4.416, and 4.682 GeV with a total integrated luminosity of 8.35  fb−1.

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  • Aad, G.
    et al.
    Aix Marseille Univ, CPPM, CNRS, IN2P3, Marseille, France.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Dimitriadi, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Bonn, Phys Inst, Bonn, Germany.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mathisen, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ördek, Serhat
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Steentoft, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Test of CP Invariance in Higgs Boson Vector-Boson-Fusion Production Using the H→γγ Channel with the ATLAS Detector2023In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 131, no 6, article id 061802Article in journal (Refereed)
    Abstract [en]

    A test of CP invariance in Higgs boson production via vector-boson fusion has been performed in the H→γγ channel using 139  fb−1 of proton-proton collision data at √s=13  TeV collected by the ATLAS detector at the LHC. The optimal observable method is used to probe the CP structure of interactions between the Higgs boson and electroweak gauge bosons, as described by an effective field theory. No sign of CP violation is observed in the data. Constraints are set on the parameters describing the strength of the CP-odd component in the coupling between the Higgs boson and the electroweak gauge bosons in two effective field theory bases: ˜d in the HISZ basis and cH˜W in the Warsaw basis. The results presented are the most stringent constraints on CP violation in the coupling between Higgs and weak bosons. The 95% C.L. constraint on ˜d is derived for the first time and the 95% C.L. constraint on cH˜W has been improved by a factor of 5 compared to the previous measurement.

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  • Gele, Abdi
    et al.
    Norwegian Inst Publ Hlth NIPH, Div Hlth Serv, Oslo, Norway..
    Jama Mahmud, Amina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Kumar, Bernadette Nirmal
    Norwegian Inst Publ Hlth NIPH, Div Hlth Serv, Oslo, Norway..
    Wangamati, Cynthia Khamala
    Univ Oslo, Div Hlth Serv, Oslo, Norway..
    Duale, Hodan A.
    Somali Inst Hlth Res SIHR, Inst Hlth & Soc, Garowe, Puntland, Somalia..
    Malik, Mamunur Rahman
    World Hlth Org, Dept Maternal Hlth, Mogadishu, Somalia..
    Gebremariam, Mekdes
    Univ Oslo, Div Hlth Serv, Oslo, Norway..
    Dybdahl, Ragnhild
    Norwegian Inst Publ Hlth NIPH, Div Hlth Serv, Oslo, Norway..
    Editorial: Encouraging health research productivity in complex humanitarian crises: Somalia2024In: Frontiers In Public Health, ISSN 2296-2565, Vol. 12, article id 1377036Article in journal (Other academic)
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  • Aad, G.
    et al.
    New York Univ Abu Dhabi, Abu Dhabi, U Arab Emirates;Univ Granada, Dept Fis Teor & Cosmos, Granada, Spain.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Dimitriadi, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Bonn, Phys Inst, Bonn, Germany.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mathisen, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mullier, Geoffrey
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ripellino, Giulia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Steentoft, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Studies of new Higgs boson interactions through nonresonant HH production in the bb-γγ final state in pp collisions at √s=13 TeV with the ATLAS detector2024In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 1, article id 66Article in journal (Refereed)
    Abstract [en]

    A search for nonresonant Higgs boson pair production in the final state is performed using 140 fb1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. This analysis supersedes and expands upon the previous nonresonant ATLAS results in this final state based on the same data sample. The analysis strategy is optimised to probe anomalous values not only of the Higgs (H) boson self-coupling modifier κλ but also of the quartic HHVV (V = W, Z) coupling modifier κ2V. No significant excess above the expected background from Standard Model processes is observed. An observed upper limit μHH < 4.0 is set at 95% confidence level on the Higgs boson pair production cross-section normalised to its Standard Model prediction. The 95% confidence intervals for the coupling modifiers are 1.4 < κλ < 6.9 and −0.5 < κ2V < 2.7, assuming all other Higgs boson couplings except the one under study are fixed to the Standard Model predictions. The results are interpreted in the Standard Model effective field theory and Higgs effective field theory frameworks in terms of constraints on the couplings of anomalous Higgs boson (self-)interactions.

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  • Bradley, Steven
    et al.
    Durham Univ, Dept Comp Sci, Durham, NC 27708 USA. San Diego State Univ, Dept Comp Sci, San Diego, CA USA..
    Parker, Miranda C.
    Altin, Rukiye
    Univ Kiel, Dept Comp Sci, Kiel, Germany..
    Barker, Lecia
    Univ Colorado, Natl Ctr Women & IT, Dept Informat Sci, Boulder, CO USA..
    Hooshangi, Sara
    Virginia Tech, Dept Comp Sci, Blacksburg, VA USA..
    Kunkeler, Thom
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Education Research. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division Vi3.
    Lennon, Ruth G.
    Atlantic Technol Univ, Dept Comp, Donegal, Ireland..
    McNeill, Fiona
    Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland..
    Minguillón, Julià
    Univ Oberta Catalunya, Dept Comp Sci Multimedia & Telecommun, Barcelona, Spain..
    Parkinson, Jack
    Univ Glasgow, Ctr Comp Sci Educ, Glasgow, Lanark, Scotland..
    Peltsverger, Svetlana
    Kennesaw State Univ, Coll Comp & Software Engn, Marietta, GA USA..
    Sibia, Naaz
    Univ Toronto, Dept Comp Sci, Toronto, ON, Canada..
    Modeling Women's Elective Choices in Computing2023In: ITiCSE-WGR '23: Proceedings of the 2023 Working Group Reports on Innovation and Technology in Computer Science Education / [ed] Mikko-Jussi Laakso; Mattia Monga; Simon; Judithe Sheard, Association for Computing Machinery (ACM), 2023, p. 196-226Conference paper (Refereed)
    Abstract [en]

    Evidence-based strategies suggest ways to reduce the gender gap in computing. For example, elective classes are valuable in enabling students to choose in which directions to expand their computing knowledge in areas aligned with their interests. The availability of electives of interest may also make computing programs of study more meaningful to women. However, research on which elective computing topics are more appealing to women is often class or institution specific. In this study, we investigate differences in enrollment within undergraduate-level elective classes in computing to study differences between women and men. The study combined data from nine institutions from both Western Europe and North America and included 272 different classes with 49,710 student enrollments. These classes were encoded using ACM curriculum guidelines and combined with the enrollment data to build a hierarchical statistical model of factors affecting student choice. Our model shows which elective topics are less popular with all students (including fundamentals of programming languages and parallel and distributed computing), and which elective topics are more popular with women students (including mathematical and statistical foundations, human computer interaction and society, ethics, and professionalism). Understanding which classes appeal to different students can help departments gain insight of student choices and develop programs accordingly. Additionally, these choices can also help departments explore whether some students are less likely to choose certain classes than others, indicating potential barriers to participation in computing.

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  • Ahmadi, Zainab
    et al.
    Lund Univ, Dept Clin Sci Lund, Resp Med Allergol & Palliat Med, Lund, Sweden..
    Björk, Joar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. Karolinska Inst, Stockholm Ctr Healthcare Eth CHE, LIME, Stockholm, Sweden.
    Gilljam, Hans
    Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden..
    Gogineni, Madhuri
    Stockholms Sjukhem, Palliat Home Care & Hosp Wards, Stockholm, Sweden..
    Gustafsson, Torbjörn
    Runold, Michael
    Karolinska Univ Hosp, Dept Resp Med & Allergy, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Resp Med Unit, Stockholm, Sweden..
    Ringbæk, Thomas
    Univ Hosp Umeå, Dept Resp Med & Allergy, Umeå, Sweden.;Allergy & Lung Clin, Elsinore, Denmark..
    Wahlberg, Josefin
    Blekinge Hosp, Dept Med, Karlskrona, Sweden..
    Wendel, Lotta
    Malmö Univ, Fac Hlth & Soc, Malmö, Sweden..
    Ekström, Magnus
    Lund Univ, Dept Clin Sci Lund, Resp Med Allergol & Palliat Med, Lund, Sweden..
    Smoking and home oxygen therapy: a review and consensus statement from a multidisciplinary Swedish taskforce2024In: European Respiratory Review, ISSN 0905-9180, E-ISSN 1600-0617, Vol. 33, no 171, article id 230194Article, review/survey (Refereed)
    Abstract [en]

    Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and policies regarding this matter. This multidisciplinary Swedish taskforce aimed to review the potential benefits and risks of smoking in relation to HOT, including medical, practical, legal and ethical considerations.

    Methods: The taskforce of the Swedish Respiratory Society comprises 15 members across respiratory medicine, nursing, medical law and ethics. HOT effectiveness and adverse risks related to smoking, as well as practical, legal and ethical considerations, were reviewed, resulting in five general questions and four PICO (population–intervention–comparator–outcome) questions. The strength of each recommendation was rated according to the GRADE (grading of recommendation assessment, development and evaluation) methodology.

    Results: General questions about the practical, legal and ethical aspects of HOT were discussed and summarised in the document. The PICO questions resulted in recommendations about assessment, management and follow-up of smoking when considering HOT, if HOT should be offered to people that meet the eligibility criteria but who continue to smoke, if a specific length of time of smoking cessation should be considered before assessing eligibility for HOT, and identification of areas for further research.

    Conclusions: Multiple factors need to be considered in the benefit/risk evaluation of HOT in active smokers. A systematic approach is suggested to guide healthcare professionals in evaluating HOT in relation to smoking.

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  • Aad, G.
    et al.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Dimitriadi, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Bonn, Phys Inst, Bonn, Germany.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mathisen, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mullier, Geoffrey
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ördek, Serhat
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ripellino, Giulia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Steentoft, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for pairs of muons with small displacements in pp collisions at √s = 13 TeV with the ATLAS detector2023In: Physics Letters B, ISSN 0370-2693, E-ISSN 1873-2445, Vol. 846, article id 138172Article in journal (Refereed)
    Abstract [en]

    A search for new phenomena giving rise to pairs of opposite electrically charged muons with impact parameters in the millimeter range is presented, using 139 fb-1 of √s = 13 TeV pp collision data from the ATLAS detector at the LHC. The search targets the gap in coverage between existing searches targeting final states with leptons with large displacement and prompt leptons. No significant excess over the background expectation is observed and exclusion limits are set on the mass of long-lived scalar supersymmetric muon-partners (smuons) with much lower lifetimes than previously targeted by displaced muon searches. Smuon lifetimes down to 1 ps are excluded for a smuon mass of 100 GeV, and smuon masses up to 520 GeV are excluded for a proper lifetime of 10 ps, at 95% confidence level. Finally, model-independent limits are set on the contribution from new phenomena to the signal-region yields.

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  • Ingelman-Sundberg, Hanna M.
    et al.
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Oncol, Stockholm, Sweden..
    Blixt, Lisa
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Haematol, Stockholm, Sweden..
    Wullimann, David
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Wu, Jinghua
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Gao, Yu
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Healy, Katie
    Karolinska Inst, Dept Dent Med, Huddinge, Sweden..
    Muschiol, Sandra
    Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden..
    Bogdanovic, Gordana
    Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden..
    Åberg, Mikael
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Kjellander, Christian
    Capio St Goran Hosp, Dept Internal Med, Stockholm, Sweden..
    Grifoni, Alba
    Karolinska Inst, Dept Lab Med, Stockholm, Sweden..
    Sette, Alessandro
    La Jolla Inst Immunol, Ctr Infect Dis & Vaccine Res, La Jolla, CA USA.;Univ Calif San Diego UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA USA..
    Aleman, Soo
    Karolinska Inst, Dept Med Huddinge, Infect Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden..
    Chen, Puran
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Blennow, Ola
    Karolinska Univ Hosp, Dept Infect Dis, Dept Transplantat, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
    Hansson, Lotta
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Haematol, Stockholm, Sweden..
    Ljunggren, Hans-Gustaf
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Sallberg Chen, Margaret
    Karolinska Inst, Dept Dent Med, Huddinge, Sweden..
    Buggert, Marcus
    Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden..
    Österborg, Anders
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Haematol, Stockholm, Sweden..
    Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia2024In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 109, no 2, p. 646-651Article in journal (Other academic)
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    FULLTEXT01
  • Aad, G.
    et al.
    Aix Marseille Univ, CNRS, CPPM, IN2P3, Marseille, France.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Dimitriadi, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Bonn, Phys Inst, Bonn, Germany.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mathisen, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mullier, Geoffrey
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ripellino, Giulia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Steentoft, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Fast b-tagging at the high-level trigger of the ATLAS experiment in LHC Run 32023In: Journal of Instrumentation, E-ISSN 1748-0221, Vol. 18, no 11, article id P11006Article in journal (Refereed)
    Abstract [en]

    The ATLAS experiment relies on real-time hadronic jet reconstruction and b-tagging to record fully hadronic events containing b-jets. These algorithms require track reconstruction, which is computationally expensive and could overwhelm the high-level-trigger farm, even at the reduced event rate that passes the ATLAS first stage hardware-based trigger. In LHC Run 3, ATLAS has mitigated these computational demands by introducing a fast neural-network-based b-tagger, which acts as a low-precision filter using input from hadronic jets and tracks. It runs after a hardware trigger and before the remaining high-level-trigger reconstruction. This design relies on the negligible cost of neural-network inference as compared to track reconstruction, and the cost reduction from limiting tracking to specific regions of the detector. In the case of Standard Model HH -> b (b) over barb (b) over bar, a key signature relying on b-jet triggers, the filter lowers the input rate to the remaining high-level trigger by a factor of five at the small cost of reducing the overall signal efficiency by roughly 2%.

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  • Basher, Grasia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Klimatpåverkan av fasta trippelinhalatorer vid kroniskt obstruktiv lungsjukdom. Kartläggning av regionala skillnader i Sverige.2023Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Introduction: Single inhaler triple therapy (SITT) is used as maintenance therapy in servereCOPD. SITT is available as dry-powder inhalers (DPIs) and pressured metered-dose inhalers(pMDIs). pMDIs have a more harmful impact on the climate compared to DPIs.

    Aim: To map changes in the prescription of SITT in Sweden and to compare regionaldifferences regarding the climate impact of the treatments.

    Methods: A mapping of recommended SITT DPIs (ATC-code: R03AL08) and pMDIs (R03AL09,R03AL11) in all 21 regions. Changes in SITT prescriptions between 2018 and 2022 were retrieved from the national statistical database and used for the climate impact calculations.The regional drug committees were interviewed to discuss factors influencing theprescription of inhalers.

    Results: Ninety percent of the regions (n=19/21) recommended DPI as the first choice SITT. The use of pMDIs increased from 0.6 to 3.3 patients per 1,000 inhabitants and DPIs from 0.3to 2.2 patients per 1,000 inhabitants during the same period. The climate impact from SITT was significantly higher in 2022 than in 2018. The climate impact for DPIs increased from 9,370 kg CO2e in 2018 to 84,297 kg CO2e in 2022. The climate impact for pMDIs increased from 291,630 kg CO2e in 2018 to 2,765,651 kg CO2e in 2022. Increased recognition of SITT and annual treatment recommendation updates were factors influencing the SITT prescriptions found in the interviews.Conclusion: The SITT use in Sweden has increased since 2018. DPIs are widelyrecommended but pMDIs are more common. There are large regional differences in theprescription and climate impact, and most of the climate impact originates from the pMDIs. Follow-up of the SITT prescriptions at a regional level is proposed to reduce the climateimpact.

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  • Watts, Eleanor L.
    et al.
    Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford , Oxford, UK.
    Perez-Cornago, Aurora
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Fensom, Georgina K.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Smith-Byrne, Karl
    Int Agcy Res Canc, Genom Epidemiol Branch, Lyon, France..
    Noor, Urwah
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Andrews, Colm D.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Gunter, Marc J.
    Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France..
    Holmes, Michael, V
    Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTS, Oxford, England.;Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England..
    Martin, Richard M.
    Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England.;Univ Hosp Bristol NHS Fdn Trust & Weston NHS Fdn, Natl Inst Hlth Res NIHR Bristol Biomed Res Ctr, Bristol, Avon, England..
    Tsilidis, Konstantinos K.
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece..
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain..
    Barricarte, Aurelio
    Navarra Publ Hlth Inst, Grp Epidemiol Canc & Other Chron Dis, Pamplona, Spain.;Navarra Inst Hlth Res IdiSNA, Grp Epidemiol Canc & Other Chron Dis, Pamplona, Spain..
    Bueno-de-Mesquita, H. Bas
    Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr Prevent & Hlth Serv, Utrecht, Netherlands..
    Cohn, Barbara A.
    Inst Publ Hlth, Child Hlth & Dev Studies, Berkeley, CA USA..
    Deschasaux-Tanguy, Melanie
    Univ Paris, Sorbonne Paris Nord Univ, Epidemiol & Stat Res Ctr, Nutr Epidemiol Res Team, Bobigny, France..
    Dimou, Niki L.
    Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France..
    Ferrucci, Luigi
    NIA, Baltimore, MD 21224 USA..
    Flicker, Leon
    Univ Western Australia, Sch Med, WA Ctr Hlth & Ageing, Perth, WA, Australia.;Univ Western Australia, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia..
    Freedman, Neal D.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia..
    Giovannucci, Edward L.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA..
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr,Ctr Genet Epidemiol, Los Angeles, CA USA..
    Hankey, Graham J.
    Univ Western Australia, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia..
    Holly, Jeffrey M. P.
    Univ Bristol, Bristol Med Sch, IGFs Metab Endocrinol Grp, Translat Hlth Sci, Bristol, Avon, England..
    Huang, Jiaqi
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.;Cent South Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ, Changsha, Hunan, Peoples R China.;Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Hunan, Peoples R China..
    Huang, Wen-Yi
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Hurwitz, Lauren M.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Kaaks, Rudolf
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany..
    Kubo, Tatsuhiko
    Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Publ Hlth & Hlth Policy, Hiroshima, Japan..
    Le Marchand, Loic
    Univ Hawaii, Ctr Canc, Honolulu, HI USA..
    MacInnis, Robert J.
    Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA..
    Mannisto, Satu
    Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland..
    Metter, E. Jeffrey
    Univ Tennessee Hlth Sci Ctr, Dept Neurol, Coll Med, Memphis, TN USA..
    Mikami, Kazuya
    Japanese Red Cross Kyoto Daiichi Hosp, Dept Urol, Kyoto, Japan..
    Mucci, Lorelei A.
    Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA..
    Olsen, Anja W.
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Danish Canc Soc, Res Ctr, Copenhagen, Denmark..
    Ozasa, Kotaro
    Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan..
    Palli, Domenico
    Inst Canc Res, Canc Risk Factors & Life Style Epidemiol Unit, Prevent & Clin Network, Florence, Italy..
    Penney, Kathryn L.
    Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA..
    Platz, Elizabeth A.
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA..
    Pollak, Michael N.
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Roobol, Monique J.
    McGill Univ, Dept Oncol, Montreal, PQ, Canada..
    Schaefer, Catherine A.
    Erasmus MC, Dept Urol, Rotterdam, Netherlands..
    Schenk, Jeannette M.
    Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA..
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Tamakoshi, Akiko
    Department of Public Health, Faculty of Medicine, Hokkaido University , Sapporo, Japan.
    Thysell, Elin
    Hokkaido Univ, Dept Publ Hlth, Fac Med, Sapporo, Hokkaido, Japan..
    Tsai, Chiaojung Jillian
    Umeå Univ, Dept Med Biosci, Umeå, Sweden..
    Touvier, Mathilde
    Van Den Eeden, Stephen K.
    Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA..
    Weiderpass, Elisabete
    Univ Calif San Francisco, Dept Urol, San Francisco, CA USA..
    Weinstein, Stephanie J.
    Wilkens, Lynne R.
    Yeap, Bu B.
    Int Agcy Res Canc, Directors Off, WHO, Lyon, France..
    Allen, Naomi E.
    Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia.;UK Biobank Ltd, Stockport, Lancs, England..
    Key, Timothy J.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis2023In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 52, no 1, p. 71-86Article in journal (Refereed)
    Abstract [en]

    Background Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate cancer. Methods Prospective analysis of biomarkers using the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset (up to 20 studies, 17 009 prostate cancer cases, including 2332 aggressive cases). Odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer were estimated using conditional logistic regression. For IGF-I, two-sample Mendelian randomization (MR) analysis was undertaken using instruments identified using UK Biobank (158 444 men) and outcome data from PRACTICAL (up to 85 554 cases, including 15 167 aggressive cases). Additionally, we used colocalization to rule out confounding by linkage disequilibrium. Results In observational analyses, IGF-I was positively associated with risks of overall (OR per 1 SD = 1.09: 95% CI 1.07, 1.11), aggressive (1.09: 1.03, 1.16) and possibly early-onset disease (1.11: 1.00, 1.24); associations were similar in MR analyses (OR per 1 SD = 1.07: 1.00, 1.15; 1.10: 1.01, 1.20; and 1.13; 0.98, 1.30, respectively). Colocalization also indicated a shared signal for IGF-I and prostate cancer (PP4: 99%). Men with higher IGF-II (1.06: 1.02, 1.11) and IGFBP-3 (1.08: 1.04, 1.11) had higher risks of overall prostate cancer, whereas higher IGFBP-1 was associated with a lower risk (0.95: 0.91, 0.99); these associations were attenuated following adjustment for IGF-I. Conclusions These findings support the role of IGF-I in the development of prostate cancer, including for aggressive disease.

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  • Mansouri, Larry
    et al.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Thorvaldsdottir, Birna
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Sutton, Lesley-Ann
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Karakatsoulis, Georgios
    Inst Appl Biosci, Ctr Res & Technol Hellas, Thessaloniki, Greece.;Univ Ioannina, Dept Math, Ioannina, Greece..
    Meggendorfer, Manja
    MLL Munich Leukemia Lab, Munich, Germany..
    Parker, Helen
    Univ Southampton, Fac Med, Sch Canc Sci, Canc Genom, Southampton, England..
    Nadeu, Ferran
    Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;Ctr Invest Biomeed Red Canc CIBERONC, Madrid, Spain..
    Brieghel, Christian
    Copenhagen Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark..
    Laidou, Stamatia
    Inst Appl Biosci, Ctr Res & Technol Hellas, Thessaloniki, Greece..
    Moia, Riccardo
    Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy..
    Rossi, Davide
    Oncol Inst Southern Switzerland, Div Hematol, Bellinzona, Switzerland.;Inst Oncol Res, Lab Expt Hematol, Bellinzona, Switzerland..
    Catherwood, Mark
    Queens Univ Belfast, Patrick G Johnston Ctr Canc Res, Belfast, Antrim, North Ireland..
    Kotaskova, Jana
    Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic..
    Delgado, Julio
    Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;Ctr Invest Biomeed Red Canc CIBERONC, Madrid, Spain.;Hosp Clin Barcelona, Barcelona, Spain.;Univ Barcelona, Barcelona, Spain..
    Rodriguez-Vicente, Ana E.
    Univ Salamanca, Canc Res Ctr IBMCC, CSIC, Salamanca, Spain.;Inst Invest Biomed IBSAL, Salamanca, Spain.;Univ Hosp Salamanca, Dept Hematol, Salamanca, Spain..
    Benito, Rocio
    Univ Salamanca, Canc Res Ctr IBMCC, CSIC, Salamanca, Spain.;Inst Invest Biomed IBSAL, Salamanca, Spain.;Univ Hosp Salamanca, Dept Hematol, Salamanca, Spain..
    Rigolin, Gian Matteo
    Univ Ferrara, Dept Med Sci, Hematol, Ferrara, Italy..
    Bonfiglio, Silvia
    Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS Osped San Raffaele, Milan, Italy..
    Scarfo, Lydia
    Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS Osped San Raffaele, Milan, Italy..
    Mattsson, Mattias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer precision medicine.
    Davis, Zadie
    Univ Hosp Dorset, Mol Pathol Dept, Bournemouth, Dorset, England..
    Gogia, Ajay
    All India Inst Med Sci AIIMS, New Delhi, India..
    Rani, Lata
    All India Inst Med Sci AIIMS, New Delhi, India..
    Baliakas, Panagiotis
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer precision medicine.
    Foroughi-Asl, Hassan
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Jylha, Cecilia
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Skaftason, Aron
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
    Rapado, Inmaculada
    Hosp Univ 12 Octubre, Madrid, Spain..
    Miras, Fatima
    Hosp Univ 12 Octubre, Madrid, Spain..
    Martinez-Lopez, Joaquin
    Hosp Univ 12 Octubre, Madrid, Spain.;Spanish Natl Canc Res CNIO, Madrid, Spain..
    de la Serna, Javier
    Hosp Univ 12 Octubre, Madrid, Spain.;Spanish Natl Canc Res CNIO, Madrid, Spain..
    Rivas, Jesus Maria Hernandez
    Thornton, Patrick
    Beaumont Hosp, Haematol Dept, Dublin, Ireland..
    Larrayoz, Maria Jose
    Univ Navarra, Hematol Dis Lab, CIMA LAB Diagnost, Pamplona, Spain.;Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain..
    Calasanz, Maria Jose
    Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain..
    Fesus, Viktoria
    Semmelweis Univ, Dept Pathol & Expt Canc Res, HCEMM SE Mol Oncohematol Res Grp, Budapest, Hungary..
    Matrai, Zoltan
    Cent Hosp Southern Pest, Natl Inst Hematol & Infect Dis, Budapest, Hungary..
    Bodor, Csaba
    Semmelweis Univ, Dept Pathol & Expt Canc Res, HCEMM SE Mol Oncohematol Res Grp, Budapest, Hungary..
    Smedby, Karin E.
    Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden..
    Espinet, Blanca
    Hosp Mar, Dept Pathol, Mol Cytogenet Lab, Barcelona, Spain.;Hosp Mar Res Inst IMIM, Translat Res Hematol Neoplasms Grp, Barcelona, Spain..
    Puiggros, Anna
    Hosp Mar, Dept Pathol, Mol Cytogenet Lab, Barcelona, Spain.;Hosp Mar Res Inst IMIM, Translat Res Hematol Neoplasms Grp, Barcelona, Spain..
    Gupta, Ritu
    All India Inst Med Sci AIIMS, New Delhi, India..
    Bullinger, Lars
    Charite Univ Med Berlin, Dept Hematol Oncol & Canc Immunol, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany..
    Bosch, Francesc
    Univ Autonoma Barcelona, Hosp Univ Vall dHebron HUVH, Vall dHebron Inst Oncol VHIO, Dept Hematol,Expt Hematol,Dept Med, Barcelona, Spain..
    Tazon-Vega, Barbara
    Univ Autonoma Barcelona, Hosp Univ Vall dHebron HUVH, Vall dHebron Inst Oncol VHIO, Dept Hematol,Expt Hematol,Dept Med, Barcelona, Spain..
    Baran-Marszak, Fanny
    Hop Avicenne, AP HP, Serv Hematol Biol, Bobigny, France..
    Oscier, David
    N'Guyen-Khac, Florence
    Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Serv Hematol Clin, Paris, France..
    Zenz, Thorsten
    Univ Hosp, Dept Oncol & Haematol, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland..
    Terol, Maria Jose
    Univ Valencia, Dept Hematol, INCL Res Inst, Valencia, Spain..
    Cuneo, Antonio
    Univ Ferrara, Dept Med Sci, Hematol, Ferrara, Italy..
    Hernandez-Sanchez, Maria
    Univ Salamanca, Canc Res Ctr IBMCC, CSIC, Salamanca, Spain.;Inst Invest Biomed IBSAL, Salamanca, Spain.;Univ Hosp Salamanca, Dept Hematol, Salamanca, Spain..
    Pospisilova, Sarka
    Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic..
    Mills, Ken
    Gaidano, Gianluca
    Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy..
    Niemann, Carsten U.
    Copenhagen Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark..
    Campo, Elias
    Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;Ctr Invest Biomeed Red Canc CIBERONC, Madrid, Spain.;Hosp Clin Barcelona, Barcelona, Spain.;Univ Barcelona, Barcelona, Spain..
    Strefford, Jonathan C.
    Univ Southampton, Fac Med, Sch Canc Sci, Canc Genom, Southampton, England..
    Ghia, Paolo
    Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS Osped San Raffaele, Milan, Italy..
    Stamatopoulos, Kostas
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Inst Appl Biosci, Ctr Res & Technol Hellas, Thessaloniki, Greece..
    Rosenquist, Richard
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Genet, Solna, Sweden..
    Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY2023In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 37, no 2, p. 339-347Article in journal (Refereed)
    Abstract [en]

    Recent evidence suggests that the prognostic impact of gene mutations in patients with chronic lymphocytic leukemia (CLL) may differ depending on the immunoglobulin heavy variable (IGHV) gene somatic hypermutation (SHM) status. In this study, we assessed the impact of nine recurrently mutated genes (BIRC3, EGR2, MYD88, NFKBIE, NOTCH1, POT1, SF3B1, TP53, and XPO1) in pre-treatment samples from 4580 patients with CLL, using time-to-first-treatment (TTFT) as the primary end-point in relation to IGHV gene SHM status. Mutations were detected in 1588 (34.7%) patients at frequencies ranging from 2.3-9.8% with mutations in NOTCH1 being the most frequent. In both univariate and multivariate analyses, mutations in all genes except MYD88 were associated with a significantly shorter TTFT. In multivariate analysis of Binet stage A patients, performed separately for IGHV-mutated (M-CLL) and unmutated CLL (U-CLL), a different spectrum of gene alterations independently predicted short TTFT within the two subgroups. While SF3B1 and XPO1 mutations were independent prognostic variables in both U-CLL and M-CLL, TP53, BIRC3 and EGR2 aberrations were significant predictors only in U-CLL, and NOTCH1 and NFKBIE only in M-CLL. Our findings underscore the need for a compartmentalized approach to identify high-risk patients, particularly among M-CLL patients, with potential implications for stratified management.

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  • Grön, Angelica
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Systematic Theology.
    Vikten av kroppsliga praktiker i relation till det andliga och spirituella: En innehållsanalys av två samtida företrädare för Svenska kyrkan2024Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats belyser kroppslighetens roll inom Svenska kyrkans liturgi, i syfte att utforska hur fysiska praktiker och sinnliga erfarenheter förmedlar och fördjupar religiös och andlig förståelse. Med en bakgrund rotad i personlig reflektion kring liturgiska traditioner, undersöker studien de specifika praktikerna och deras inverkan på deltagande och uttryck av det gudomliga. Genom en kvalitativ metodik, inklusive en detaljerad innehållsanalys, utforskar denna uppsats två samtida teologers syn på kroppslighet: Martin Modéus och Lena Sjöstrand. Avgränsningar görs för att koncentrera sig på dessa två författares arbeten, som ligger till grund för de empiriska och teoretiska insikter som presenteras. I analysen framkommer det att kroppslighet och sinnlighet är centralt för förståelsen av Svenska kyrkans liturgi, vilket utmanar idén om Ordet som den främsta medlaren av det gudomliga mötet. Resultaten tyder på att kroppsliga gudstjänstpraktiker är betydelsefulla inte bara för den individuella spiritualiteten utan även för att stärka gemenskapskänslan bland församlingsmedlemmar. Uppsatsen avslutar med en diskussion om de möjliga konsekvenserna av kroppsligheten för den bredare kyrkliga praxis samt för framtidens forskningsriktningar - såsom inkluderingen av mångfaldiga kroppsliga erfarenheter i Svenska kyrkans gudstjänstliv. Denna studie bidrar till fördjupad förståelse för hur liturgiska praktiker både kan uttrycka och forma tro i samtidens församlingskontext. 

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  • Pedersén, Olof
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    The Tower of Babylon stele found in Babylon2024In: Iraq, ISSN 0021-0889, p. 1-13Article in journal (Refereed)
    Abstract [en]

    In the early 1990s the two fragments of black stone making up the Tower of Babylon stele with pictures of the ziggurat in Babylon and the king Nebuchadnezzar II were found in the large open trench from the German excavations of Amran in 1900. The findspot was about 20 m north of the Esagil temple in Babylon, but the level where it was discovered is not Neo-Babylonian but later, possibly Parthian. The archaeological and historical background of the stele is discussed, and the image of the Ziggurat on the stele is considered. After 28 years in the Schøyen Collection Oslo, the stele is now in the Iraq Museum in Baghdad. 

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  • Abadie, V.
    et al.
    Hop Univ Necker, Paris, France..
    Bohorquez, D.
    Vall Hebron, Barcelona, Spain..
    Bulstrode, N. W.
    Great Ormond St Hosp Sick Children, London, England..
    Davies, Gareth
    Hakelius, Malin
    Uppsala Univ Hosp, Uppsala, Sweden..
    Ong, J.
    Great Ormond St Hosp Sick Children, London, England..
    Mathijssen, I. M. J.
    Erasmus MC, Rotterdam, Netherlands..
    Matos, E.
    Santa Maria Hosp, Lisbon, Portugal..
    Mazzoleni, F.
    San Gerardo Hosp, Monza, Italy..
    van der Molen, A. Mink
    Utrecht Med Ctr, Utrecht, Netherlands..
    Muradin, M.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Neovius, E.
    Karolinska Hosp, Stockholm, Sweden..
    Piacentile, K.
    San Bortolo Hosp Vicenza, Vicenza, Italy..
    Redondo, M.
    Hosp 12 Octobre, Madrid, Spain..
    Vuola, P.
    Helsinki Univ Hosp, Helsinki, Finland..
    Wolvius, E. B.
    Erasmus MC, Rotterdam, Netherlands..
    Reinert, Siegmar
    Plast Operationen, Klin & Poliklin Mund Kiefer & Gesichtschirurg, Tubingen, Germany..
    Murray, Dylan
    Childrens Univ Hosp, Craniofacial Team, Temple St, Dublin, Ireland.;Karolinska Inst, Plast Surg & ENT, Stockholm, Sweden..
    Peterson, Petra
    Hens, Greet
    Katholieke Univ Leuven, Dept Neurowetenschappen, Leuven, Belgium..
    Schachner, P.
    Sivertsen, A.
    Irvine, W. F. E.
    Qualicura, Breda, Netherlands..
    Welling-van Overveld, L. F. J.
    Qualicura, Breda, Netherlands..
    van Breugel, M.
    Utrecht Med Ctr, Utrecht, Netherlands..
    van Schalkwijk, K.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Verhey, E.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Khan, A.
    Great Ormond St Hosp Sick Children, London, England..
    Baillie, L.
    Great Ormond St Hosp Sick Children, London, England..
    Bishop, N.
    Great Ormond St Hosp Sick Children, London, England..
    Hillyar, C. R. T.
    Great Ormond St Hosp Sick Children, London, England..
    Koudstaal, M. J.
    Erasmus MC, Rotterdam, Netherlands..
    van de lande, L.
    Great Ormond St Hosp Sick Children, London, England..
    Nibber, A.
    Great Ormond St Hosp Sick Children, London, England..
    Panciewicz, N.
    Great Ormond St Hosp Sick Children, London, England..
    Ramjeeawan, A.
    Great Ormond St Hosp Sick Children, London, England..
    Bouter, A.
    Erasmus MC, Rotterdam, Netherlands..
    El Ghoul, K.
    Erasmus MC, Rotterdam, Netherlands..
    Logjes, B.
    Erasmus MC, Rotterdam, Netherlands..
    van der Plas, P.
    Erasmus MC, Rotterdam, Netherlands..
    Kats, J.
    Erasmus MC, Rotterdam, Netherlands..
    Weissbach, E.
    Erasmus MC, Rotterdam, Netherlands..
    van Veen-van der Hoek, M.
    Erasmus MC, Rotterdam, Netherlands..
    Bittermann, A. J. N.
    Utrecht Med Ctr, Utrecht, Netherlands..
    van den Boogaard, M-JH.
    Coenraad, S.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Dulfer, K.
    Erasmus MC, Rotterdam, Netherlands..
    Joosten, K.
    Erasmus MC, Rotterdam, Netherlands..
    Lachmeijer, A. M. A.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Muradin, M. S. M.
    Utrecht Med Ctr, Utrecht, Netherlands..
    Peters, N. C. J.
    Erasmus MC, Rotterdam, Netherlands..
    Pleumeekers, M.
    Erasmus MC, Rotterdam, Netherlands..
    de Veye, H. Swanenburg
    Utrecht Med Ctr, Utrecht, Netherlands..
    European Guideline Robin Sequence An Initiative From the European Reference Network for Rare Craniofacial Anomalies and Ear, Nose and Throat Disorders (ERN-CRANIO)2024In: The Journal of Craniofacial Surgery, ISSN 1049-2275, E-ISSN 1536-3732, Vol. 35, no 1, p. 279-361Article in journal (Refereed)
    Abstract [en]

    A European guideline on Robin Sequence was developed within the European Reference Network for rare and/ or complex craniofacial anomalies and ear, nose, and throat disorders. The guideline provides an overview of optimal care provisions for patients with Robin Sequence and recommendations for the improvement of care.

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  • Johnson, Benjamin B.
    et al.
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Cosson, Marie-Victoire
    Francis Crick Inst, London NW1 1AT, England.;Imperial Coll London, NHLI, London, England..
    Tsansizi, Lorenza I.
    Francis Crick Inst, London NW1 1AT, England.;Imperial Coll London, NHLI, London, England..
    Holmes, Terri L.
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Gilmore, Tegan
    Francis Crick Inst, London NW1 1AT, England..
    Hampton, Katherine
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Song, Ok-Ryul
    Francis Crick Inst, London NW1 1AT, England.;Francis Crick Inst, High Throughput Screening Sci Technol Platform, London NW1 1AT, England..
    Vo, Nguyen T. N.
    Univ Nottingham, Biodiscovery Inst, Sch Med Regenerating & Modelling Tissues, Univ Pk, Nottingham NG7 2RD, England..
    Nasir, Aishah
    Univ Nottingham, Biodiscovery Inst, Sch Med Regenerating & Modelling Tissues, Univ Pk, Nottingham NG7 2RD, England..
    Chabronova, Alzbeta
    Inst Life Course & Med Sci, William Henry Duncan Bldg,6 West Derby St, Liverpool L7 8TX, England..
    Denning, Chris
    Univ Nottingham, Biodiscovery Inst, Sch Med Regenerating & Modelling Tissues, Univ Pk, Nottingham NG7 2RD, England..
    Peffers, Mandy J.
    Inst Life Course & Med Sci, William Henry Duncan Bldg,6 West Derby St, Liverpool L7 8TX, England..
    Merry, Catherine L. R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Nottingham, Biodiscovery Inst, Sch Med Regenerating & Modelling Tissues, Univ Pk, Nottingham NG7 2RD, England..
    Whitelock, John
    Univ Nottingham, Biodiscovery Inst, Sch Med Regenerating & Modelling Tissues, Univ Pk, Nottingham NG7 2RD, England.;Univ New South Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia..
    Troeberg, Linda
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Rushworth, Stuart A.
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Bernardo, Andreia S.
    Francis Crick Inst, London NW1 1AT, England.;Imperial Coll London, NHLI, London, England..
    Smith, James G. W.
    Univ East Anglia, Ctr Metab Hlth, Norwich Med Sch, Norwich Res Pk, Norwich NR4 7UQ, England..
    Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes2024In: Cell Reports, E-ISSN 2211-1247, Vol. 43, no 1, article id 113668Article in journal (Refereed)
    Abstract [en]

    Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases as cardiomyocytes mature in vivo and during human pluripotent stem cell differentiation to cardiomyocytes (hPSC-CMs). Perlecan-haploinsuffient hPSCs (HSPG2(+/-)) differentiate efficiently, but late-stage CMs have structural, contractile, metabolic, and ECM gene dysregulation. In keeping with this, late -stage HSPG2(+/-) hPSC-CMs have immature features, including reduced alpha-actinin expression and increased glycolytic metabolism and proliferation. Moreover, perlecan-haploinsuffient engineered heart tissues have reduced tissue thickness and force generation. Conversely, hPSC-CMs grown on a perlecanpeptide substrate are enlarged and display increased nucleation, typical of hypertrophic growth. Together, perlecan appears to play the opposite role of agrin, promoting cellular maturation rather than hyperplasia and proliferation. Perlecan signaling is likely mediated via its binding to the dystroglycan complex. Targeting perlecan-dependent signaling may help reverse the phenotypic switch common to heart failure.

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  • Fortes-Lima, Cesar A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Burgarella, Concetta
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution. Univ Montpellier, AGAP Inst, Inst Agro, CIRAD,INRAE, Montpellier, France..
    Hammarén, Rickard
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Eriksson, Anders
    Univ Tartu, Inst Genom, cGEM, Tartu, Estonia..
    Vicente, Mario
    Univ Stockholm, Ctr Palaeogenet, Stockholm, Sweden.;Stockholm Univ, Dept Archaeol & Class Studies, Stockholm, Sweden..
    Jolly, Cecile
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Semo, Armando
    Univ Porto, Ctr Invest Biodiversidade & Recursos Genet, CIBIO, Vairao, Portugal.;CIBIO, BIOPOLIS Program Genom Biodivers & Land Planning, Campus Vairao, Vairao, Portugal.;Univ Porto, Fac Ciencias, Dept Biol, Porto, Portugal..
    Gunnink, Hilde
    Univ Ghent, UGent Ctr Bantu Studies BantUGent, Dept Languages & Cultures, Ghent, Belgium.;Leiden Univ, Ctr Linguist, Leiden, Netherlands..
    Pacchiarotti, Sara
    Univ Ghent, UGent Ctr Bantu Studies BantUGent, Dept Languages & Cultures, Ghent, Belgium..
    Mundeke, Leon
    Univ Kinshasa, Kinshasa, DEM REP CONGO..
    Matonda, Igor
    Univ Kinshasa, Kinshasa, DEM REP CONGO..
    Muluwa, Joseph Koni
    Inst Super Pedag Kikwit, Kikwit, DEM REP CONGO..
    Coutros, Peter
    Univ Ghent, UGent Ctr Bantu Studies BantUGent, Dept Languages & Cultures, Ghent, Belgium..
    Nyambe, Terry S.
    Livingstone Museum, Livingstone, Zambia..
    Cikomola, Justin Cirhuza
    Catholic Univ Bukavu, Fac Med, Bukavu, DEM REP CONGO..
    Coetzee, Vinet
    Univ Pretoria, Dept Biochem Genet & Microbiol, Pretoria, South Africa..
    de Castro, Minique
    Agr Res Council, Biotechnol Platform, Pretoria, South Africa..
    Ebbesen, Peter
    Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark..
    Delanghe, Joris
    Univ Ghent, Dept Diagnost Sci, Ghent, Belgium..
    Stoneking, Mark
    Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany.;Univ Lyon 1, Lab Biometrie & Biol Evolut, UMR 5558, CNRS, Villeurbanne, France..
    Barham, Lawrence
    Univ Liverpool, Dept Archaeol Class & Egyptol, Liverpool, England..
    Lombard, Marlize
    Univ Johannesburg, Palaeo Res Inst, Johannesburg, South Africa..
    Meyer, Anja
    Univ Witwatersrand, Fac Hlth Sci, Sch Anat Sci, Human Variat & Identificat Res Unit, Johannesburg, South Africa..
    Steyn, Maryna
    Univ Witwatersrand, Fac Hlth Sci, Sch Anat Sci, Human Variat & Identificat Res Unit, Johannesburg, South Africa..
    Malmström, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution. Univ Johannesburg, Palaeo Res Inst, Johannesburg, South Africa..
    Rocha, Jorge
    Univ Porto, Ctr Invest Biodiversidade & Recursos Genet, CIBIO, Vairao, Portugal.;CIBIO, BIOPOLIS Program Genom Biodivers & Land Planning, Campus Vairao, Vairao, Portugal.;Univ Porto, Fac Ciencias, Dept Biol, Porto, Portugal..
    Soodyall, Himla
    Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Div Human Genet, Johannesburg, South Africa.;Acad Sci South Africa, Pretoria, South Africa..
    Pakendorf, Brigitte
    CNRS, Dynam Langage, UMR5596, Lyon, France.;Univ Lyon, Lyon, France..
    Bostoen, Koen
    Univ Ghent, UGent Ctr Bantu Studies BantUGent, Dept Languages & Cultures, Ghent, Belgium..
    Schlebusch, Carina
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab. Univ Johannesburg, Palaeo Res Inst, Johannesburg, South Africa..
    The genetic legacy of the expansion of Bantu-speaking peoples in Africa2024In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 625, no 7995, p. 540-547Article in journal (Refereed)
    Abstract [en]

    The expansion of people speaking Bantu languages is the most dramatic demographic event in Late Holocene Africa and fundamentally reshaped the linguistic, cultural and biological landscape of the continent1-7. With a comprehensive genomic dataset, including newly generated data of modern-day and ancient DNA from previously unsampled regions in Africa, we contribute insights into this expansion that started 6,000-4,000 years ago in western Africa. We genotyped 1,763 participants, including 1,526 Bantu speakers from 147 populations across 14 African countries, and generated whole-genome sequences from 12 Late Iron Age individuals8. We show that genetic diversity amongst Bantu-speaking populations declines with distance from western Africa, with current-day Zambia and the Democratic Republic of Congo as possible crossroads of interaction. Using spatially explicit methods9 and correlating genetic, linguistic and geographical data, we provide cross-disciplinary support for a serial-founder migration model. We further show that Bantu speakers received significant gene flow from local groups in regions they expanded into. Our genetic dataset provides an exhaustive modern-day African comparative dataset for ancient DNA studies10 and will be important to a wide range of disciplines from science and humanities, as well as to the medical sector studying human genetic variation and health in African and African-descendant populations.

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  • Hold, Katharina
    et al.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Lord, Edana
    Ctr Palaeogenet, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Swedish Museum Nat Hist, Dept Bioinformat & Genet, S-10405 Stockholm, Sweden.;Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden..
    Brealey, Jaelle C.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway.;Norwegian Inst Nat Res NINA, Dept Terr Ecol, Hogskoleringen 9, N-7034 Trondheim, Norway..
    Le Moullec, Mathilde
    Norwegian Univ Sci & Technol NTNU, Gjaerevoll Ctr Biodivers Foresight Anal, N-7491 Trondheim, Norway.;Inst Nat Resources, Dept Mammals & Birds, Kivioq 2, Nuuk 3900, Greenland..
    Bieker, Vanessa C.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Ellegaard, Martin R.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Rasmussen, Jacob A.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway.;Univ Copenhagen, Globe Inst, Oster Voldgade 5-7, DK-1350 Copenhagen, Denmark..
    Kellner, Fabian L.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Guschanski, Katerina
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ Edinburgh, Inst Ecol & Evolut, Sch Biol Sci, Edinburgh, Scotland..
    Yannic, Glenn
    Univ Grenoble Alpes, Univ Savoie Mont Blanc, Lab Ecol Alpine, CNRS,LECA, F-38000 Grenoble, France..
    Røed, Knut H.
    Norwegian Univ Life Sci, Dept Preclin Sci & Pathol, POB 5003, N-1432 As, Norway..
    Hansen, Brage B.
    Norwegian Univ Sci & Technol NTNU, Gjaerevoll Ctr Biodivers Foresight Anal, N-7491 Trondheim, Norway.;Norwegian Inst Nat Res NINA, Dept Terr Ecol, Hogskoleringen 9, N-7034 Trondheim, Norway..
    Dalen, Love
    Ctr Palaeogenet, Svante Arrhenius Vag 20C, S-10691 Stockholm, Sweden.;Swedish Museum Nat Hist, Dept Bioinformat & Genet, S-10405 Stockholm, Sweden.;Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden..
    Martin, Michael D.
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Dussex, Nicolas
    Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, Dept Nat Hist, Erling Skakkes Gate 47B, N-7012 Trondheim, Norway..
    Ancient reindeer mitogenomes reveal island-hopping colonisation of the Arctic archipelagos2024In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, article id 4143Article in journal (Refereed)
    Abstract [en]

    Climate warming at the end of the last glacial period had profound effects on the distribution of cold-adapted species. As their range shifted towards northern latitudes, they were able to colonise previously glaciated areas, including remote Arctic islands. However, there is still uncertainty about the routes and timing of colonisation. At the end of the last ice age, reindeer/caribou (Rangifer tarandus) expanded to the Holarctic region and colonised the archipelagos of Svalbard and Franz Josef Land. Earlier studies have proposed two possible colonisation routes, either from the Eurasian mainland or from Canada via Greenland. Here, we used 174 ancient, historical and modern mitogenomes to reconstruct the phylogeny of reindeer across its whole range and to infer the colonisation route of the Arctic islands. Our data shows a close affinity among Svalbard, Franz Josef Land and Novaya Zemlya reindeer. We also found tentative evidence for positive selection in the mitochondrial gene ND4, which is possibly associated with increased heat production. Our results thus support a colonisation of the Eurasian Arctic archipelagos from the Eurasian mainland and provide some insights into the evolutionary history and adaptation of the species to its High Arctic habitat.

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  • Public defence: 2024-04-05 10:15 Geijersalen, sal 6-1023, Uppsala
    Elfström, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Reconceiving Public Reason: Neutrality, Civility, and the Self-Defeat Objection2024Doctoral thesis, monograph (Other academic)
    Abstract [en]

    How should we live together? The question is at the heart of social ethics and it is an as urgent political question as ever. In this thesis, one particularly attractive reply to this central issue is analysed—John Rawls’s theory of public reason, and three different objections that have been put against it. Rawls’s theory is an approach to democratic decision-making. According to it, the exercise of political power should be neutral. Secondly, the exercise of political power should restrict the reasons that have justificatory force in political decision-making procedures to reasons that do not rely on any particular worldview. Finally, the exercise of political power is legitimate only if it is in accordance with terms of cooperation that all reasonable and rational persons can accept.

    The objections each target one of these components. Cécile Laborde has challenged the conception of neutrality espoused by egalitarian liberals generally. Egalitarian liberal understandings of neutrality do not take sufficient account of all relevant dimensions of our worldviews and often confuse neutral policies with what conforms to the status quo. Jeffrey Stout, in turn, targets the constraints on public discourse and argues that imposing such constraints is unfair to religious citizens because it distributes the burdens of cooperation to their disadvantage. Finally, Steven Wall argues that the requirement that the legitimate exercise of political power be acceptable to citizens ends up defeating itself.

    These arguments are tested and I consider the alternative approaches that are presented by each of the three critics. I propose that neutrality should be rejected, as equality better captures the end pursued by demanding neutral treatment of different worldviews. I then go on to revise the constraints that Rawls impose. Although many of Stout’s arguments are persuasive, Rawls’s constraints on political discourse are introduced for very good reasons. Finally, I argue that Wall’s self-defeat argument fails and that Rawls’s principle of legitimacy need not be revised, but is defendable in its current form. 

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  • Dubayev, Akhmedkhan
    et al.
    Copenhagen Univ Hosp, Rigshosp, Neurosci Ctr, Multidisciplinary Pain Ctr, Copenhagen, Denmark..
    Kjær Jensen, Elisabeth
    Copenhagen Univ Hosp, Rigshosp, Neurosci Ctr, Multidisciplinary Pain Ctr, Copenhagen, Denmark..
    Geving Andersen, Kenneth
    Copenhagen Univ Hosp, Hvidovre Hosp, Dept Anesthesia & Intens Care, Hvidovre, Denmark..
    Bjurström, Martin F.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Pain.
    Werner, Mads U.
    Copenhagen Univ Hosp, Rigshosp, Neurosci Ctr, Multidisciplinary Pain Ctr, Copenhagen, Denmark..
    Quantitative somatosensory assessments in patients with persistent pain following groin hernia repair: A systematic review with a meta-analytical approach2024In: PLOS ONE, E-ISSN 1932-6203, Vol. 19, no 1, article id e0292800Article, review/survey (Refereed)
    Abstract [en]

    Objectives

    Quantitative sensory testing (QST) provides an assessment of cutaneous and deep tissue sensitivity and pain perception under normal and pathological settings. Approximately 2–4% of individuals undergoing groin hernia repair (GHR) develop severe persistent postsurgical pain (PPSP). The aims of this systematic review of PPSP-patients were (1) to retrieve and methodologically characterize the available QST literature and (2) to explore the role of QST in understanding mechanisms underlying PPSP following GHR.

    Methods

    A systematic literature search was conducted from JAN-1992 to SEP-2022 in PubMed, EMBASE, and Google Scholar. For inclusion, studies had to report at least one QST-modality in patients with PPSP. Risk of bias assessment of the studies was conducted utilizing the Newcastle Ottawa Scale and Cochrane’s Risk of Bias assessment tool 2.0. The review provided both a qualitative and quantitative analysis of the results. A random effects model was used for meta-analysis.

    Results

    Twenty-five studies were included (5 randomized controlled trials, 20 non-randomized controlled trials). Overall, risk of bias was low. Compared with the contralateral side or controls, there were significant alterations in somatosensory function of the surgical site in PPSP-patients. Following thresholds were significantly increased: mechanical detection thresholds for punctate stimuli (mean difference (95% CI) 3.3 (1.6, 6.9) mN (P = 0.002)), warmth detection thresholds (3.2 (1.6, 4.7) °C (P = 0.0001)), cool detection thresholds (-3.2 (-4.9, -1.6) °C (P = 0.0001)), and heat pain thresholds (1.9 (1.1, 2.7) °C (P = 0.00001)). However, the pressure pain thresholds were significantly decreased (-76 (-123, -30) kPa (P = 0.001)).

    Conclusion

    Our review demonstrates a plethora of methods used regarding outcome assessments, data processing, and data interpretation. From a pathophysiological perspective, the most consistent findings were postsurgical cutaneous deafferentation and development of a pain generator in deeper connective tissues.

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  • Maranesi, Margherita
    et al.
    Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy..
    Palmioli, Elisa
    Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy.;Dept Philosophy Social Sci & Educ, PhD Course Ethics Commun Sci Res, PhD Course Ethics Commun Sci Res & Technol Innovat, Piazza G Ermini 1, I-06123 Perugia, IT, Italy..
    Dall'Aglio, Cecilia
    Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy..
    Marini, Daniele
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Physiology and Environmental Toxicology. Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy..
    Anipchenko, Polina
    Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy..
    De Felice, Elena
    Univ Camerino, Sch Biosci & Vet Med, Via Pontoni 5, IT-62032 Camerino, IT, Italy..
    Scocco, Paola
    Univ Camerino, Sch Biosci & Vet Med, Via Pontoni 5, IT-62032 Camerino, IT, Italy..
    Mercati, Francesca
    Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy..
    Resistin in endocrine pancreas of sheep: Presence and expression related to different diets2024In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 348, article id 114452Article in journal (Refereed)
    Abstract [en]

    Resistin (RETN), a recently discovered adipokine, is a cysteine-rich and secretory protein produced by adipocytes. RETN has been detected in several tissues, including human and laboratory animals' pancreas, wherein impairs glucose tolerance and insulin (INS) action and causes INS resistance. This study aims to evaluate the presence and expression of RETN in the pancreas of 15 adult female sheep reared on Apennine pastures, which show a decrease in their nutritional value due to the drought stress linked to the increasing summer aridity. The sheep were divided into 3 groups according to the diet they were subjected to: maximum pasture flowering (MxF) group, maximum pasture dryness (MxD) group, and experimental (Exp) group which received a feed supplementation in addition to the MxD group feeding. Immunohistochemistry and immunofluorescence were performed on formalin-fixed and paraffin-embedded sections of the pancreas to detect the RETN presence and to evaluate the co-localization of RETN with both glucagon (GCG)- and INS-producing cells. In addition, the expression of the three molecules was evaluated also in relation to different diets. RETN was observed only in the endocrine pancreas, showing a wide distribution throughout the pancreatic islets with few negative cells and the RETN producing cells colocalized with both alpha cells and ss cells. No differences in distribution and immunostaining intensity of RETN, GCG and INS were observed among the three groups. Quantitative PCR showed the expression of RETN, GCG and INS in all tested samples. No significant differences were observed for RETN and GCG among all three groups of sheep. Instead, a high statistically significant expression of INS was detected in the MxF group with respect to the Exp and MxD groups. These results highlight the localization of RETN in GCG- and INS-secreting cells involved in glucose homeostasis suggesting a modulatory role for RETN. Furthermore, the RETN expression is not influenced by food supplementation and thus is not affected by diet.

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  • Sangeorzan, Irina
    et al.
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Antonacci, Grazia
    Imperial Coll London, Appl Res Collaborat ARC Northwest London, Natl Inst Hlth Res NIHR, Dept Primary Care & Publ Hlth, London, England.;Imperial Coll London, Ctr Hlth Econ & Policy Innovat CHEPI, Business Sch, London, England..
    Martin, Anne
    Canterbury Christ Church Univ, Fac Med Hlth & Social Care, Canterbury, England..
    Grodzinski, Ben
    Univ Hosp Sussex NHS Fdn Trust, Brighton, England..
    Zipser, Carl M.
    Balgrist Univ Hosp, Spinal Cord Injury Ctr, Zurich, Switzerland..
    Murphy, Rory K. J.
    St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ USA..
    Andriopoulou, Panoraia
    Univ Ioannina, Sch Social Sci, Psychol Dept, Ioannina, Greece..
    Cook, Chad E.
    Duke Univ, Sch Med, Div Phys Therapy, Durham, CA USA.;Duke Univ, Sch Med, Dept Orthopaed, Durham, CA USA.;Duke Univ, Sch Med, Dept Populat Hlth Sci, Durham, CA USA.;Duke Univ, Duke Clin Res Inst, Durham, CA USA..
    Anderson, David B.
    Univ Sydney, Fac Med & Hlth, Sydney Sch Hlth Sci, Sydney, Australia..
    Guest, James
    Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL USA..
    Furlan, Julio C.
    Univ Toronto, Dept Med, Div Phys Med & Rehabil, Toronto, ON, Canada.;Univ Hlth Network, KITE Res Inst, Toronto Rehabil Inst, Toronto, ON, Canada..
    Kotter, Mark R. N.
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom.;Univ Cambridge, Dept Clin Neurosurg, Cambridge, England..
    Boerger, Timothy F.
    Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI USA..
    Sadler, Iwan
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Roberts, Elizabeth A.
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Wood, Helen
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Fraser, Christine
    Univ Stirling, Dept Hlth Sci, Stirling, Scotland.;Natl Hlth Serv Lothian, Physiotherapy Dept, Edinburgh, Scotland..
    Fehlings, Michael G.
    Univ Toronto, Dept Surg, Div Neurosurg & Spine Program, Toronto, ON, Canada.;Univ Hlth Network, Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, Toronto, ON, Canada..
    Kumar, Vishal
    Postgrad Inst Med Educ & Res, Dept Orthopaed, Chandigarh, India.;All India Inst Med Sci, Dept Orthopaed, Deoghar, India..
    Jung, Josephine
    Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.;Kings Coll Hosp London, Dept Neurosurg, London, England..
    Milligan, James
    McMaster Univ, Dept Family Med, Hamilton, ON, Canada..
    Nouri, Aria
    Univ Geneva, Geneva Univ Hosp, Div Neurosurg, Geneva, Switzerland..
    Martin, Allan R.
    Univ Calif Davis, Dept Neurol Surg, Davis, CA USA..
    Blizzard, Tammy
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Vialle, Luiz Roberto
    Pontif Catholic Univ Parana, Sch Med, Curitiba, Brazil..
    Tetreault, Lindsay
    NYU, Dept Neurol, New York, NY USA..
    Kalsi-Ryan, Sukhvinder
    Univ Hlth Network, KITE Res Inst, Toronto Rehabil Inst, Toronto, ON, Canada.;Univ Toronto, Dept Surg, Toronto, ON, Canada..
    MacDowall, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics and Handsurgery. Acad Hosp Uppsala, Dept Orthopaed, Uppsala, Sweden..
    Martin-Moore, Esther
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Burwood, Martin
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Wood, Lianne
    Univ Exeter, Fac Hlth & Life Sci, Exeter, England.;Nottingham Univ Hosp NHS Trust, NeuroSpinal Assessment Unit, Nottingham, England..
    Lalkhen, Abdul
    Salford Royal NHS Fdn Trust, Northern Care Alliance, Manchester, England..
    Ito, Manabu
    Natl Hosp Org Hokkaido Med Ctr, Dept Orthopaed Surg, Sapporo, Japan..
    Wilson, Nicky
    Kings Coll Hosp NHS Fdn Trust, Physiotherapy Dept, London, England..
    Treanor, Caroline
    Beaumont Hosp, Dept Physiotherapy, Dublin, Ireland.;Beaumont Hosp, Dept Neurosurg, Dublin, Ireland.;Royal Coll Surgeons Ireland, Sch Physiotherapy, Dublin, Ireland..
    Dugan, Sheila
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom..
    Davies, Benjamin M.
    Myelopathy org, Cambridge, Cambridgeshire, United Kingdom.;Univ Cambridge, Dept Clin Neurosurg, Cambridge, England.;Univ Cambridge, Addenbrookes Hosp, Dept Clin Neurosurg, Box 167,Cambridge Biomed Campus, Cambridge CB2 0QQ, England..
    Toward Shared Decision-Making in Degenerative Cervical Myelopathy: Protocol for a Mixed Methods Study2023In: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 12, article id e46809Article in journal (Refereed)
    Abstract [en]

    Background: Health care decisions are a critical determinant in the evolution of chronic illness. In shared decision-making (SDM), patients and clinicians work collaboratively to reach evidence-based health decisions that align with individual circumstances, values, and preferences. This personalized approach to clinical care likely has substantial benefits in the oversight of degenerative cervical myelopathy (DCM), a type of nontraumatic spinal cord injury. Its chronicity, heterogeneous clinical presentation, complex management, and variable disease course engenders an imperative for a patient-centric approach that accounts for each patient's unique needs and priorities. Inadequate patient knowledge about the condition and an incomplete understanding of the critical decision points that arise during the course of care currently hinder the fruitful participation of health care providers and patients in SDM. This study protocol presents the rationale for deploying SDM for DCM and delineates the groundwork required to achieve this.

    Objective: The study's primary outcome is the development of a comprehensive checklist to be implemented upon diagnosis that provides patients with essential information necessary to support their informed decision-making. This is known as a core information set (CIS). The secondary outcome is the creation of a detailed process map that provides a diagrammatic representation of the global care workflows and cognitive processes involved in DCM care. Characterizing the critical decision points along a patient's journey will allow for an effective exploration of SDM tools for routine clinical practice to enhance patient-centered care and improve clinical outcomes.

    Methods: Both CISs and process maps are coproduced iteratively through a collaborative process involving the input and consensus of key stakeholders. This will be facilitated by Myelopathy.org, a global DCM charity, through its Research Objectives and Common Data Elements for Degenerative Cervical Myelopathy community. To develop the CIS, a 3-round, web-based Delphi process will be used, starting with a baseline list of information items derived from a recent scoping review of educational materials in DCM, patient interviews, and a qualitative survey of professionals. A priori criteria for achieving consensus are specified. The process map will be developed iteratively using semistructured interviews with patients and professionals and validated by key stakeholders.

    Results: Recruitment for the Delphi consensus study began in April 2023. The pilot-testing of process map interview participants started simultaneously, with the formulation of an initial baseline map underway.

    Conclusions: This protocol marks the first attempt to provide a starting point for investigating SDM in DCM. The primary work centers on developing an educational tool for use in diagnosis to enable enhanced onward decision-making. The wider objective is to aid stakeholders in developing SDM tools by identifying critical decision junctures in DCM care. Through these approaches, we aim to provide an exhaustive launchpad for formulating SDM tools in the wider DCM community.

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  • Zhao, Xinran O.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Melo, Fabio Rabelo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Sommerhoff, Christian P.
    Institute of Medical Education and Institute of Laboratory Medicine LMU University Hospital Munich Germany.
    Paivandy, Aida
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Pejler, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells2024In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995Article in journal (Other academic)
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  • Scheding, Ben
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    1920-talets ekonomiska kris i Tyskland: En studie av två samhällens levnadsförhållanden utifrån socioekonomiska faktorer under 1920-talskrisen2024Student paper second term, 5 credits / 7,5 HE creditsStudent thesis
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    Krisåren i Tyskland - En studie av två samhällens levnadsförhållanden utifrån socioekonomiska faktorer under 1920-talskrisen av Ben Scheding