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  • Thorslund, Ellenore
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienter upplevelser av stamcellstransplantation och skyddsisolering: En litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Johansson, Alexander
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Kommunismens himmelska mandat: Juche som en symbios av marxism-leninism, nationalism och konfucianism2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This essay is a hermeneutic reading and analysis of the swedish translation of a selection of Kim il Sungs political writings (jucheidén och dess lysande segrar, 1975). The book consists primarily of impairments of speeches and interviews that Kim participated in or held between 1965-1972. By analyzing his political statements, I intend to show the potential that the concept of Juche is a constructed symbiosis consisted of Confucianism, Marxism-Leninism and nationalism, and to describe how they function together to legitimize Kim il Sung’s political agenda. Furthermore, I intend to present the internal and external complexities which can have contributed to the creation of Juche and the historical effects that can be expected from this symbiosis.    

         Primarily I will focus on the concept of family, androcentric view of history and the important of culture politics as a mean to unite and control the population of the Peoples Republic of Korea. The purpose of this essay is not simply to point out what is Confucianism respectively Communism, but simply to suggest the possibility to read in a Confucian context in some statements made by Kim il Sung.

         The interpretation is theoretically based on Timothy Fitzgerald’s concept of critical religion, which points out religion as an irrelevant and disable concept, combined with Anna Suns argumentation of Confucianism as a non-essential teaching and western invented concept.

  • Public defence: 2019-02-08 09:00 Vårdskolans Aula, Västerås
    Isacson, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    Treatment of Acute Uncomplicated Colonic Diverticulitis2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of this thesis was to evaluate the clinical management of AUD with regard to the no-antibiotic policy and its long-term effect, treatment on an outpatient basis and the potential health-care cost savings

    Study I:  a retrospective study at Västmanlands Hospital that evaluated and confirmed the adherence to the no-antibiotic policy in patients with AUD and its safety regarding complications and recurrences. A total of 246 patients with acute diverticulitis were identified, of which 195 had computed tomography (CT) confirmed AUD. In total, 91.3% of these patients did not receive any antibiotics and only two developed complications.

    Study II: a retrospective study with the aim to conduct a long-term follow-up of all Swedish patients who participated in the AVOD trial in terms of recurrences, complications, surgery and quality of life. The medical records of 96% of the patients were reviewed with a mean follow up of 11 years. Quality of life questionnaires were sent out to all patients. There were no differences regarding the rates of recurrence, complications or surgery for diverticulitis. There were no differences in the quality of life between groups according to the EQ-5D questionnaire.

    Study III: a prospective study where 155 patients with CT-verified AUD as were treated as outpatients without antibiotics. On day 3, patients reported an average pain score of 1.8 of 10 on the VAS scale and only 30% of patients were using analgesia. Four patients returned to hospital because of treatment failure.

    Study IV: a retrospective cohort study at Västmanland’s Hospital evaluated the impact on admissions, complication rates and health-care costs of the policy of outpatient treatment without using antibiotics. Medical records of all patients diagnosed with AUD in the year before (2011) and after (2014) the implementation of outpatient management without antibiotics were reviewed. Overall 494 episodes of AUD were identified: 254 in 2011 and 240 in 2014. Three patients developed complications in 2011 and four in 2014. The proportion of patients managed as outpatients was 20% in 2011 compared with 61% in 2014. The hospital admissions, total length of stay of and total health-care costs were almost halved.

    In conclusion, these studies confirm the low complication and recurrence rates of AUD and strengthens findings that antibiotics have no benefit in the treatment of this disease. The no-antibiotic policy had no impact on short- or long-term outcomes regarding the rates of recurrence, complications, surgery or quality of life. Outpatient management was found to be feasible and safe, and significantly reduced admissions, which led to large health-care cost savings.

    List of papers
    1. No antibiotics in acute uncomplicated diverticulitis: does it work?
    Open this publication in new window or tab >>No antibiotics in acute uncomplicated diverticulitis: does it work?
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    2014 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 49, no 12, p. 1441-1446Article in journal (Refereed) Published
    Abstract [en]

    Background. The first randomized multicenter study evaluating the need for antibiotic treatment in patients with acute uncomplicated diverticulitis (AUD) could not demonstrate any benefit gained from antibiotic use. The aim of this study was to review the application of the no antibiotic policy and its consequences in regard to complications and recurrence. Methods. This retrospective population-based cohort study included all patients diagnosed with all types of colonic diverticulitis during the year 2011 at Vastmanland Hospital Vasteras, Sweden. All medical records were carefully reviewed. Primary outcomes were the types of treatment adopted for diverticulitis, complications and recurrence. Results. In total, 246 patients with computer tomography-verified diverticulitis were identified, 195 with primary AUD and 51 with acute complicated diverticulitis. Age, sex, and temperature at admission were similar between the groups but there was a significant difference in white blood cell count, C-reactive protein, and length of hospital stay. In the AUD group, 178 (91.3%) patients were not treated with antibiotics. In this group, there were six (3.4%) readmissions but only two developed an abscess. Of the remaining 17 patients (8.7%) who were treated with antibiotics in the AUD group, one developed an abscess. Twenty-five (12.8%) patients in the AUD group presented with a recurrence within 1 year. Conclusion. The no-antibiotic policy for AUD is safe and applicable in clinical practice. The previous results of a low complication and recurrence rate in AUD are confirmed. There is no need for antibiotic treatment for AUD. What does this paper add to the literature? Despite published papers with excellent results, there are still doubts about patient safety against the policy to not use antibiotics in acute uncomplicated diverticulitis. This is the first paper, in actual clinical practice, to confirm that the no antibiotic policy for acute uncomplicated diverticulitis is applicable and safe.

    Keywords
    antibiotics, colonic diverticulitis, complications
    National Category
    Gastroenterology and Hepatology
    Identifiers
    urn:nbn:se:uu:diva-240083 (URN)10.3109/00365521.2014.968861 (DOI)000345603500007 ()25369865 (PubMedID)
    Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2018-12-10Bibliographically approved
    2. Antibiotic avoidance in patients with acute uncomplicated diverticulitis: ten-year follow-up of a randomized clinical trial
    Open this publication in new window or tab >>Antibiotic avoidance in patients with acute uncomplicated diverticulitis: ten-year follow-up of a randomized clinical trial
    (English)In: Article in journal (Refereed) Submitted
    Keywords
    Diverticulitis, antibiotics, recurrent diverticulitis, sigmoidectomy
    National Category
    Surgery
    Identifiers
    urn:nbn:se:uu:diva-369127 (URN)
    Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-20
    3. Outpatient, non-antibiotic management in acute uncomplicated diverticulitis: a prospective study
    Open this publication in new window or tab >>Outpatient, non-antibiotic management in acute uncomplicated diverticulitis: a prospective study
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    2015 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 30, no 9, p. 1229-1234Article in journal (Refereed) Published
    Abstract [en]

    The aim of this study was to evaluate outpatient, non-antibiotic management in acute uncomplicated diverticulitis with regard to admissions, complications, and recurrences, within a 3-month follow-up period. A prospective, observational study in which patients with computer tomography-verified acute uncomplicated diverticulitis were managed as outpatients without antibiotics. The patients kept a personal journal, were contacted daily by a nurse, and then followed up by a surgeon at 1 week and 3 months. In total, 155 patients were included, of which 54 were men; the mean age of the patients was 57.4 years. At the time of diagnosis, the mean C-reactive protein and white blood cell count were 73 mg/l and 10.5 x 10(9), respectively, and normalized in the vast majority of patients within the first week. The majority of the patients (97.4 %) were managed successfully as outpatients without antibiotics, admissions, or complications. In only four (2.6 %) patients, the management failed because of complications in three and deterioration in one. These patients were all treated successfully as inpatients without surgery. Five patients had recurrences and were treated as outpatients without antibiotics. Follow-up colonic investigations revealed cancer in two patients and polyps in 13 patients. Previous results of low complication rates with the non-antibiotic policy were confirmed. The new policy of outpatient management without antibiotics in acute uncomplicated diverticulitis is now shown to be feasible, well functioning, and safe.

    Keywords
    Diverticulitis, Outpatient management, Antibiotics
    National Category
    Health Care Service and Management, Health Policy and Services and Health Economy Clinical Medicine
    Identifiers
    urn:nbn:se:uu:diva-262965 (URN)10.1007/s00384-015-2258-y (DOI)000360542000011 ()25989930 (PubMedID)
    Note

    Correction in: International Journal of Colorectal Disease, 2015, vol. 30, issue 9, pages 1225-1235, doi: 10.1007/s00384-015-2284-9

    Available from: 2015-09-24 Created: 2015-09-23 Last updated: 2018-12-10Bibliographically approved
    4. Outpatient management of acute uncomplicated diverticulitis results in health-care cost savings
    Open this publication in new window or tab >>Outpatient management of acute uncomplicated diverticulitis results in health-care cost savings
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    2018 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 53, no 4, p. 449-452Article in journal (Refereed) Published
    Abstract [en]

    Purpose:

    Outpatient management without antibiotics has been shown to be safe for selected patients diagnosed with acute uncomplicated diverticulitis (AUD). The aim of this study was to evaluate the impact on admissions, complication rates and health-care costs of the policy of outpatient treatment without using antibiotics.

    Methods:

    The medical records of all patients diagnosed with AUD in the year before (2011) and after (2014) the implementation of outpatient management without antibiotics in Vastmanland County were reviewed. Health-care cost analysis was performed using the Swedish cost-per-patient model.

    Results:

    In total, 494 episodes of AUD were identified, 254 in 2011 and 240 in 2014. The proportion of patients managed as outpatients was 20% in 2011 compared with 60% in 2014 (p<.001). There were 203 hospital admissions and a total length of stay of 677 days in 2011 compared with 95 admissions and 344 days in 2014 (both p<.001). The total health-care cost was Euro558,679 in 2011 compared with Euro370,370 in 2014 (p<.001). Three patients developed complications in 2011 and four in 2014 (p=.469).

    Conclusions:

    The new policy of outpatient management without antibiotics in routine health care almost halved the total health-care cost without an increase in the complication rate.

    Keywords
    Diverticulitis, outpatient management, antibiotics, health-care costs
    National Category
    Gastroenterology and Hepatology
    Identifiers
    urn:nbn:se:uu:diva-354262 (URN)10.1080/00365521.2018.1448887 (DOI)000430726600011 ()29543100 (PubMedID)
    Available from: 2018-06-28 Created: 2018-06-28 Last updated: 2018-12-10Bibliographically approved
  • Kou, R. H.
    et al.
    Northeastern Univ, Key Lab Electromagnet Proc Mat, Minist Educ, Shenyang 110819, Liaoning, Peoples R China;Argonne Natl Lab, Adv Photon Source, Lemont, IL 60439 USA.
    Gao, J.
    Northeastern Univ, Key Lab Electromagnet Proc Mat, Minist Educ, Shenyang 110819, Liaoning, Peoples R China.
    Ren, Y.
    Argonne Natl Lab, Adv Photon Source, Lemont, IL 60439 USA.
    Sanyal, Biplab
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Bhandary, S.
    Univ Paris Saclay, CNRS, Ecole Polytech, CPHT, Route Saclay, F-91128 Palaiseau, France.
    Heald, S. M.
    Argonne Natl Lab, Adv Photon Source, Lemont, IL 60439 USA.
    Fisher, B.
    Argonne Natl Lab, Ctr Nanoscale Mat, Lemont, IL 60439 USA.
    Sun, C. -J
    Charge transfer-tuned magnetism in Nd-substituted Gd5Si42018In: AIP Advances, ISSN 2158-3226, E-ISSN 2158-3226, Vol. 8, no 12, article id 125219Article in journal (Refereed)
    Abstract [en]

    We report a charge-transfer mechanism in tuning of magnetism of Nd-substituted Gd5-xNdxSi4 (x=1 and 2.5) compounds. The X-ray absorption near edge structure measurements demonstrated that Nd substitutions for Gd induce charge transfer of 5d electrons from Gd to Nd. The charge transfer weakens spin-orbital coupling of Gd but strengthens that of Nd. Consequently, the magnetization responses of the substituted compounds to low magnetic fields are increased while their saturation magnetization is reduced. Electronic structure calculations showed that the charge transfer stabilizes a ferromagnetic and a ferrimagnetic structure in the compounds with x = 1 and 2.5, respectively, but that it does not change the 5d-3p hybridization significantly. It is suggested that the charge transfer of 5d electrons may occur in other rare earth-substituted Gd5Si4 compounds allowing for tuning of their magnetism.

  • Oscarsson, Jan
    et al.
    AstraZeneca Gothenburg, Pepparedsleden 1, S-43183 Molndal, Sweden.
    Onnerhag, Kristina
    Lund Univ, Dept Clin Sci, Malmo, Sweden.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Sunden, Mattias
    AstraZeneca Gothenburg, Pepparedsleden 1, S-43183 Molndal, Sweden.
    Johansson, Lars
    Antaros Med AB, Molndal, Sweden.
    Jansson, Per-Anders
    Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.
    Moris, Linda
    Karolinska Univ Hosp, Karolinska Trial Alliance, Solna, Sweden.
    Nilsson, Peter M.
    Lund Univ, Dept Clin Sci, Malmo, Sweden.
    Eriksson, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study2018In: Journal of Clinical Lipidology, ISSN 1933-2874, E-ISSN 1876-4789, Vol. 12, no 6, p. 1390-1403Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Treatment with omega-3 fatty acids and fenofibrates reduces serum triglyceride levels, but few studies have compared the effect of these agents on liver fat. OBJECTIVE: The aim of the EFFECT I trial (NCT02354976) was to determine the effects of free omega-3 carboxylic acids (OM-3CA) and fenofibrate on liver fat in overweight or obese individuals with non-alcoholic fatty liver disease and hypertriglyceridemia. METHODS: Seventy-eight patients were randomized to receive oral doses of 4 g OM-3CA (n = 25), 200 mg fenofibrate (n = 27), or placebo (n = 26) for 12 weeks in a double-blind, parallel-group study. Liver proton density fat fraction (PDFF) and volume, pancreas volume, and adipose tissue volumes were assessed by magnetic resonance imaging. RESULTS: Changes in liver PDFF at 12 weeks were not significantly different across treatment groups (relative changes from baseline: placebo, +4%; OM-3CA, -2%; and fenofibrate, +17%). The common PNPLA3 genetic polymorphism (I148M) did not significantly influence the effects of OM-3CA or fenofibrate on liver PDFF. Fenofibrate treatment significantly increased liver and pancreas volumes vs placebo treatment, and the changes in liver and pancreas volumes were positively correlated (rho 0.45, P = .02). Total liver fat volume increased significantly in patients using fenofibrate vs OM-3CA (+23% vs 3%, P = .04). Compared with OM-3CA, fenofibrate increased total liver fat and liver volume. Serum triglycerides decreased with OM-3CA (-26%, P = .02) and fenofibrate (-38%, P < .001) vs placebo. In contrast to OM-3CA, fenofibrate reduced plasma docosahexaenoic acid levels and increased plasma acetylcarnitine and butyrylcarnitine levels, estimated delta-9 desaturase activity and the concentration of urine F2-isoprostanes. CONCLUSIONS: OM-3CA and fenofibrate reduced serum triglycerides but did not reduce liver fat. Fenofibrate increased total liver volume and total liver fat volume vs OM-3CA, indicating a complex effect of fenofibrate on human hepatic lipid metabolism.

  • Public defence: 2019-02-08 13:00 Gunnesalen, Uppsala
    Skorup, Paul
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. Some national guidelines advocate single β-lactam antibiotic treatment while others recommend a combination of β-lactam and aminoglycoside. This thesis aimed to investigate the anti-bacterial properties and antibiotic-induced inflammatory responses of ß-lactam antibiotic compared with effects of the addition of an aminoglycoside in clinically relevant E. coli porcine intensive care sepsis/septic shock models. We also studied the host's antibacterial capacities in primary and secondary sepsis.

    In Paper I the addition of an aminoglycoside, in comparison with single β-lactam antibiotic treatment,  caused decreased bacterial growth in the liver and greater antibiotic-induced blood killing activity ex vivo. The results thereby constitute possible mechanisms to the previously reported improved survival in the most critically ill sepsis patients receiving the β-lactam/aminoglycoside combination. Also observed in this paper was that individual blood bactericidal capacity may have significant effects on antimicrobial outcome.  

    In Paper II we investigated endotoxin release in vivo after antibiotic treatment in comparison with no treatment. There were no differences, however, antibiotics did increase an inflammatory IL-6 response that was associated with leukocyte activation and pulmonary organ dysfunction. A secondary finding was that the addition of an aminoglycoside to a β-lactam induced trends towards less inflammation compared with β-lactam alone.

    Paper III compared how challenge with different pre-killed E. coli activates the inflammatory response, resulting in higher cytokine responses, more leucocyte activation and inflammatory capillary leakage after single β-lactam compared with live or heat-killed bacteria. The addition of an aminoglycoside lowered the β-lactam-induced responses.

    Paper IV demonstrated that animals with secondary sepsis exhibited an attenuated inflammatory response as expected; however, contrary to our hypothesis, the animals’ antibacterial capacities were intact and partly enhanced.

    We conclude that there are likely several beneficial effects of the addition of an aminoglycoside to a β-lactam therapy regimen in septic shock. Because host antibacterial capacities in secondary sepsis are enhanced, the need for bactericidal antibiotic combinations is not greater in secondary than in primary sepsis.

    List of papers
    1. Beneficial Antimicrobial Effect of the Addition of an Aminoglycoside to a β-Lactam Antibiotic in an E. coli Porcine Intensive Care Severe Sepsis Model.
    Open this publication in new window or tab >>Beneficial Antimicrobial Effect of the Addition of an Aminoglycoside to a β-Lactam Antibiotic in an E. coli Porcine Intensive Care Severe Sepsis Model.
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    2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 2, p. e90441-Article in journal (Refereed) Published
    Abstract [en]

    This study aimed to determine whether the addition of an aminoglycoside to a ß-lactam antibiotic increases the antimicrobial effect during the early phase of Gram-negative severe sepsis/septic shock. A porcine model was selected that considered each animal's individual blood bactericidal capacity. Escherichia coli, susceptible to both antibiotics, was given to healthy pigs intravenously during 3 h. At 2 h, the animals were randomized to a 20-min infusion with either cefuroxime alone (n = 9), a combination of cefuroxime+tobramycin (n = 9), or saline (control, n = 9). Blood samples were collected hourly for cultures and quantitative polymerase chain reaction (PCR). Bacterial growth in the organs after 6 h was chosen as the primary endpoint. A blood sample was obtained at baseline before start of bacterial infusion for ex vivo investigation of the blood bactericidal capacity. At 1 h after the administration of the antibiotics, a second blood sample was taken for ex vivo investigation of the antibiotic-induced blood killing activity. All animals developed severe sepsis/septic shock. Blood cultures and PCR rapidly became negative after completed bacterial infusion. Antibiotic-induced blood killing activity was significantly greater in the combination group than in the cefuroxime group (p<0.001). Growth of bacteria in the spleen was reduced in the two antibiotic groups compared with the controls (p<0.01); no difference was noted between the two antibiotic groups. Bacterial growth in the liver was significantly less in the combination group than in the cefuroxime group (p<0.05). High blood bactericidal capacity at baseline was associated with decreased growth in the blood and spleen (p<0.05). The addition of tobramycin to cefuroxime results in increased antibiotic-induced blood killing activity and less bacteria in the liver than cefuroxime alone. Individual blood bactericidal capacity may have a significant effect on antimicrobial outcome.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-220397 (URN)10.1371/journal.pone.0090441 (DOI)000332396200200 ()24587365 (PubMedID)
    Available from: 2014-03-13 Created: 2014-03-13 Last updated: 2018-12-12Bibliographically approved
    2. Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model
    Open this publication in new window or tab >>Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model
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    2018 (English)In: Critical Care Medicine, ISSN 0090-3493, E-ISSN 1530-0293, Vol. 46, no 7, p. e634-e641Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVES: To investigate the dynamics of antibiotic-induced endotoxin liberation and inflammatory response in vivo in a clinically relevant large animal intensive care sepsis model and whether the addition of an aminoglycoside to a β-lactam antibiotic affects these responses.

    DESIGN: Prospective, placebo-controlled interventional experimental study.

    SETTING: University research unit.

    SUBJECTS: Thirty-six healthy pigs administered Escherichia coli as a 3-hour infusion.

    INTERVENTIONS: After 2 hours, during E. coli infusion, the animals were exposed to cefuroxime alone, the combination of cefuroxime and tobramycin, or saline.

    MEASUREMENTS AND MAIN RESULTS: Plasma endotoxin, interleukin-6, tumor necrosis factor-α, leucocytes, and organ dysfunction were recorded for 4 hours after antibiotic treatment, and differences to the values before treatment were calculated. In vitro experiments were performed to ascertain whether endotoxin is released during antibiotic-induced bacterial killing of this E. coli strain. Despite differences between the treatment arms in vitro, no differences in plasma endotoxin were observed in vivo. Antibiotic-treated animals demonstrated a higher interleukin-6 response (p < 0.001), greater leucocyte activation (p < 0.001), and more pronounced deterioration in pulmonary static compliance (p < 0.01) over time than controls. Animals treated with the combination showed a trend toward less inflammation.

    CONCLUSIONS: Treatment with antibiotics may elicit an increased inflammatory interleukin-6 response that is associated with leucocyte activation and pulmonary organ dysfunction. No observable differences were detected in plasma endotoxin concentrations. The reduction in cefuroxime-induced endotoxin release after the addition of an aminoglycoside in vitro could not be reproduced in this model.

    National Category
    Infectious Medicine
    Identifiers
    urn:nbn:se:uu:diva-349226 (URN)10.1097/CCM.0000000000003139 (DOI)000435290400002 ()29595561 (PubMedID)
    Available from: 2018-04-23 Created: 2018-04-23 Last updated: 2018-12-12Bibliographically approved
    3. Mode of Bacterial Killing Affects the Inflammatory Response and Associated Organ Dysfunctions in a Porcine E. coli Intensive Care Sepsis Model
    Open this publication in new window or tab >>Mode of Bacterial Killing Affects the Inflammatory Response and Associated Organ Dysfunctions in a Porcine E. coli Intensive Care Sepsis Model
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    (English)Manuscript (preprint) (Other academic)
    Keywords
    Antibiotics, Bacteria, Sepsis, Cytokines, Inflammation, Porcine
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-366974 (URN)
    Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2018-12-12Bibliographically approved
    4. Enhanced Bacterial Clearance at a Secondary Sepsis Challenge in an Endotoxin-tolerant Porcine Intensive Care Model
    Open this publication in new window or tab >>Enhanced Bacterial Clearance at a Secondary Sepsis Challenge in an Endotoxin-tolerant Porcine Intensive Care Model
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    (English)Manuscript (preprint) (Other academic)
    Keywords
    Secondary sepsis, Endotoxin-tolerance, Bacteria, E. coli, Porcine, ICU
    National Category
    Medical and Health Sciences Infectious Medicine
    Identifiers
    urn:nbn:se:uu:diva-366977 (URN)
    Note

    P Skorup and F Wilske contributed equally to this work.

    Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2018-12-12Bibliographically approved
  • Segerdahl, Margareta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Genuskontraktet i idealrelationen: En undersökning av hur kärleksrelationer framställs i Mitt Livs Novell 1964–19942019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Holst, Anna
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
    Ginter, Annika
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Hlth Metr, Gothenburg, Sweden.
    Bjorkelund, Cecilia
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
    Hange, Dominique
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
    Petersson, Eva-Lisa
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden;Reg Vastra Gotaland, Narhalsan Res & Dev Primary Hlth Care, Gothenburg, Sweden.
    Svenningsson, Irene
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden;Reg Vastra Gotaland, Narhalsan Res & Dev Primary Hlth Care, Gothenburg, Sweden.
    Westman, Jeanette
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden.
    Andre, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Wikberg, Carl
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
    Wallin, Lars
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Nursing, Stockholm, Sweden;Univ Gothenburg, Sahlgrenska Acad, Dept Hlth & Care Sci, Gothenburg, Sweden.
    Moller, Christina
    Reg Vastra Gotaland, Narhalsan, Primary Hlth Care Head Off, Hisings Backa, Sweden.
    Svensson, Mikael
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Hlth Metr, Gothenburg, Sweden.
    Cost-effectiveness of a care manager collaborative care programme for patients with depression in primary care: economic evaluation of a pragmatic randomised controlled study2018In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 11, article id e024741Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate the cost-effectiveness of a care manager (CM) programme compared with care as usual (CAU) for treatment of depression at primary care centres (PCCs) from a healthcare as well as societal perspective.

    Design: Cost-effectiveness analysis.

    Setting: 23 PCCs in two Swedish regions.

    Participants: Patients with depression (n=342).

    Main outcome measures: A cost-effectiveness analysis was applied on a cluster randomised trial at PCC level where patients with depression had 3 months of contact with a CM (11 intervention PCCs, n=163) or CAU (12 control PCCs, n=179), with follow-up 3 and 6 months. Effectiveness measures were based on the number of depression-free days (DFDs) calculated from the Montgomery-angstrom sberg Depression Rating Scale-Self and quality-adjusted life years (QALYs).

    Results were expressed as the incremental cost-effectiveness ratio: Cost/QALY and Cost/DFD. Sampling uncertainty was assessed based on non-parametric bootstrapping.

    Results: Health benefits were higher in intervention group compared with CAU group: QALYs (0.357 vs 0.333, p<0.001) and DFD reduction of depressive symptom score (79.43 vs 60.14, p<0.001). The mean costs per patient for the 6-month period were Euro368 (healthcare perspective) and Euro6217 (societal perspective) for the intervention patients and Euro246 (healthcare perspective) and Euro7371 (societal perspective) for the control patients (n.s.). The cost per QALY gained was Euro6773 (healthcare perspective) and from a societal perspective the CM programme was dominant.

    Discussion: The CM programme was associated with a gain in QALYs as well as in DFD, while also being cost saving compared with CAU from a societal perspective. This result is of high relevance for decision-makers on a national level, but it must be observed that a CM programme for depression implies increased costs at the primary care level.

  • Haapala, Willy
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Historia på längden, tvären och diagonalen: En historiedidaktisk undersökning av historieskrivning på olika nivåer med nedslag vid åren 1965 och 20102019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Laurent, Sofie
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Probability Theory.
    The mathematical justifiction of the Leontief and Sraffa input-output systems2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Mak, Alan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Salén, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Goryashko, Vitaliy
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Clarke, Jim
    STFC Daresbury Laboratory, Warrington, United Kingdom.
    Science Requirements and Performance Specification forthe CompactLight X-Ray Free-Electron Laser2019Report (Other academic)
    Abstract [en]

    CompactLight is a consortium funded by the European Union through the Horizon 2020 Research and Innovation Programme under Grant Agreement No. 777431.  This report summarizes science requirements and performance specification for the CompactLight x-ray free-electron laser. 

  • Montan, Ola
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    ...den tillkommande världens liv: En ecklesiologisk analys av Biörn Fjärstedts herdabrev till Visby stift 19912018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2019-02-08 13:15 Brusewitzsalen, Uppsala
    Khoban, Zohreh
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Deliberation, against all odds?: The critical prospects of mini-publics2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In recent decades, the theory of deliberative democracy has encountered multiple challenges. In this thesis, I explore the prospects of a particular type of deliberative democratic institution – deliberative mini-publics – in three essays. In the first essay, I discuss the challenge of combining mini-publics with institutions for preference aggregation, such as elections. I address the concern that citizens of a society dominated by aggregative institutions could be discouraged from the collective and cooperative form of participation required by mini-publics. Studying the effect of the right to vote on citizenship norms, I find no support for this concern. On the contrary, I show that elections boost support for non-electoral forms of political participation. In the second essay, I focus on the concept of descriptive representation in mini-publics to investigate previous studies’ tendency to introduce aggregative elements to deliberative institutions. I find that current conceptualizations of descriptive representation in the mini-publics literature tend to primarily address concerns about the democratic legitimacy of a political institution consisting of unelected representatives. I argue that mini-publics can be considered legitimate if the notion of legitimacy is detached from elections. After showing that mini-publics do not necessarily suffer from a lack of legitimacy, I suggest an argument for descriptive representation that better serves the mini-publics' aim of facilitating high-quality deliberation. The third essay is motivated by a call from theorists to treat social differences as a resource that can enhance deliberative processes, rather than an obstacle. I test whether emphasizing social differences in mini-publics makes humble communication and reflexivity – elements that constitute normative conditions of deliberation – less likely. Analysing the effect of increased social group salience on expectations of deliberation, I find that emphasizing group differences raises expectations of observing and acknowledging differences without lowering the prospects of humble communication and reflexivity.

    List of papers
    1. What citizens learn from elections: The normative consequences of the right to vote
    Open this publication in new window or tab >>What citizens learn from elections: The normative consequences of the right to vote
    (English)Manuscript (preprint) (Other academic)
    National Category
    Political Science (excluding Public Administration Studies and Globalisation Studies)
    Identifiers
    urn:nbn:se:uu:diva-368964 (URN)
    Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-11
    2. Interpretative interactions: An argument for descriptive representation in deliberative mini-publics
    Open this publication in new window or tab >>Interpretative interactions: An argument for descriptive representation in deliberative mini-publics
    (English)Manuscript (preprint) (Other academic)
    National Category
    Political Science (excluding Public Administration Studies and Globalisation Studies)
    Identifiers
    urn:nbn:se:uu:diva-368967 (URN)
    Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-11
    3. Social difference and the common good: An experiment on the effect of group salience on citizen deliberation
    Open this publication in new window or tab >>Social difference and the common good: An experiment on the effect of group salience on citizen deliberation
    (English)Manuscript (preprint) (Other academic)
    National Category
    Political Science (excluding Public Administration Studies and Globalisation Studies)
    Identifiers
    urn:nbn:se:uu:diva-368968 (URN)
    Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-11
  • Wallerius, Johan Gottschalk
    Affiliation.
    Dissertationem de terra salina sterili, consent. ampliss. facult. philosoph. in reg. acad. Upsaliensi præside ... Joh. Gotschalk Wallerio, ... in audit. Gustav. ad diem [tomrum] Martii anni MDCCLXIV. Horis ante meridiem consvetis, pro gradu philosophico, publico defert examini Petrus Tenggreen, Arbogia Westmannus.1764Dissertation (older thesis) (Other academic)
  • Hjalmarsson, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Church and Mission studies.
    "Till Herren fly, om du vill sällhet vinna!": Om att leva sitt liv i Kristi efterföljd utifrån den baptistiska sångboken Psalmisten 19282018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Walladbegi, Java
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.
    Svanberg, Anncarin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Gellerstedt, Martin
    Univ West, Sch Business Econ & IT, Trollhattan, Sweden.
    Protocol for a randomised controlled trial to study cryoprevention of chemotherapy-induced oral mucositis after autologous stem cell transplantation2018In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 10, article id e021993Article in journal (Refereed)
    Abstract [en]

    Introduction: A majority of patients who receive myeloablative therapy prior to hematopoetic stem cell transplantation develop oral mucositis (OM). This adverse cytotoxic effect manifests as oral mucosal erythema and ulcerations and frequently necessitates high doses of morphine for pain alleviation. OM may also interfere with food intake and result in parenteral nutrition, weight loss and impaired quality of life. To date, there have been a few studies of evidence-based interventions for prevention of OM. Cooling the oral mucosa using ice chips in conjunction with chemotherapy is known to reduce the severity of OM although clinical application is still limited due to several disadvantages. The primary endpoint of this study is therefore to evaluate the efficacy of an innovative intraoral cooling device (Cooral) compared with ice cooling in reducing the degree of OM, in patients with myeloma or lymphoma.

    Method and analysis: A total of 180 patients from four different university hospitals in Sweden will be randomised to ice or Cooral in a proportion of 1:1. The degree of OM will be assessed at eight intraoral locations, in accordance with the Oral Mucositis Assessment Scale and WHO scale. Patients will be registered beginning at admission and will continue until discharge or until day +28. The primary variable is analysed in a multiple linear regression model. The significance level used is 5%.

    Ethics and dissemination: The study protocol, questionnaire, diaries and letter of invitation to participants have been reviewed by the local ethical board in Goteborg. The trial results will be published in a peer-reviewed journal and disseminated to participants.

  • Pallavicini, Nicola
    et al.
    Lulea Univ Technol, Div Geosci & Environm Engn, S-97187 Lulea, Sweden;ALS Scandinavia AB, ALS Lab Grp, Aurorum 10, S-97775 Lulea, Sweden.
    Engstrom, Emma
    Lulea Univ Technol, Div Geosci & Environm Engn, S-97187 Lulea, Sweden;ALS Scandinavia AB, ALS Lab Grp, Aurorum 10, S-97775 Lulea, Sweden.
    Baxter, Douglas C.
    ALS Scandinavia AB, ALS Lab Grp, Aurorum 10, S-97775 Lulea, Sweden.
    Ohlander, Bjorn
    Lulea Univ Technol, Div Geosci & Environm Engn, S-97187 Lulea, Sweden.
    Ingri, Johan
    Lulea Univ Technol, Div Geosci & Environm Engn, S-97187 Lulea, Sweden.
    Hawley, Scott
    Univ Durham, Dept Earth Sci, Durham, England.
    Hirst, Catherine
    Nat Hist Museum, Dept Geosci, Stockholm, Sweden.
    Rodushkina, Katerina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Rodushkin, Ilia
    Lulea Univ Technol, Div Geosci & Environm Engn, S-97187 Lulea, Sweden;ALS Scandinavia AB, ALS Lab Grp, Aurorum 10, S-97775 Lulea, Sweden.
    Ranges of B, Cd, Cr, Cu, Fe, Pb, Sr, Tl, and Zn Concentrations and Isotope Ratios in Environmental Matrices from an Urban Area2018In: Journal of Spectroscopy, ISSN 2314-4920, E-ISSN 2314-4939, article id 7408767Article in journal (Refereed)
    Abstract [en]

    Isotopic information may provide powerful insight into the elemental cycling processes which occur in natural compartments. Further implementation of isotopic techniques in natural sciences requires a better understanding of the range of elemental and isotopic compositional variability in environmental matrices. This study assesses the local-scale concentration and isotopic composition variability of nine elements: boron (B), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), strontium (Sr), thallium (Tl), and zinc (Zn) in lysimetric waters, mushrooms, litter, needles, leaves, and lichens. Sequential extractions were also performed on soil samples from 6 depth profiles providing more detailed information on the variability of elemental concentrations and isotope ratios between the elemental pools present in soil. For most of the sample types studied the range of isotopic variability between samples spans almost the entire ranges reported in the literature for natural samples. These results represent a starting point for discussing the role of natural variability in isotopic studies (for example, as a limiting factor in the use of isotopic mixing models) and a baseline for future in-depth studies examining the controls on isotope fraction in natural systems.

  • Janegren, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Upplevelse av självbestämmande vid mat och måltid bland äldre personer som bor i ordinärt boende2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Specialistsjuksköterskan med inriktning vård av äldre ska arbeta med ett personcentrarat förhållningsätt där både patienten och sjuksköterskans kunskaper och erfarenheter är viktiga för utformandet av vården. Delaktighet och självbestämmande kring det som rör mat och måltider kan leda till en positiv självkänsla och förhindra undernäring hos äldre personer iordinärt boende.Syftet med studien var att undersöka upplevelsen av självbestämmande hos äldre personer med biståndsbeslut som rör måltiden, genom att undersöka hur de upplevde att de var delaktiga och kunde påverka kring maten, måltiden och måltidsmiljön.

    Studien genomfördes som en kvalitativ intervjustudie. Tio deltagare i åldern 69- 97 år som hade insatser som rörde mat och måltider i Örebro kommun intervjuades. De transkriberadesvaren analyserades sedan med kvalitativ innehållsanalys.

    Att välja från matlistan innebar en möjlighet att vara delaktig och påverka samtidigt som dessa maträtter var förutbestämda, och valet var därmed begränsat. Matlistan var svår att fylla i självständigt och det hände att fel maträtt valdes. Svårigheter att tillreda enklare maträtter på egen hand beskrevs. Att förenkla eller förbereda var strategier för att kunna vara delaktig eller självständig. Om assistans behövdes från personalen för att exempelvis värma matlådan framkom också att personalens rutiner delvis styrde när måltiden intogs. Även medicinering eller behov av assistans vid omvårdnad påverkade när måltiden kunde intas. Sjukdom, nedsatt ork och mobilitet kunde påverka delaktigheten i göromål runt måltiden och möjligheten att påverka måltidsmiljön. Måltiden intogs helst tillsammans med andra.

    Att ha insatser som rör mat och måltider innebar olika möjligheter att påverka och vara delaktiga i det som rör maten, måltiden och måltidsmiljön för de som deltog i studien.

  • Strandh, Spencer
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    "I gemenskap": Dopsyn och dopliturgi i 2016 års förslag till kyrkohandbok för Equmeniakyrkan2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Yildiz, Robin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hedlund, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienternas kost- och vätskeregistreringar på sjukhus: Kvalitativ studie om vårdpersonalens upplevelser av dokumentering av kost- och vätskeregistreringar2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Malnutrition and dehydration are serious but common concerns within healthcare that have consequences both for the patient and the society. Adequate nutrition is important to promote health and prevent illness within patients. Aim: The aim of the study was to study nurses and assistant nurse’s experiences of the documentation of food and fluid intake. Method: An inductive study of descriptive design with a qualitative approach was performed. Semistructured interviews with six nurses and six assistant nurses were completed. Qualitative content analysis was used to analyze the date. Results: The result consist of four categories: The outlook on the situation, Attitude and adherence, Knowledge and Working environment. In the interviews it appeared that the look on diet records varied between departments and staff in the same department. The majority thought that the diet and fluid records were functioning poorly or being improved. The respondents perceived that the reasons for the flaws were the attitude and compliance of all involved people, knowledge of nutrition and routines and the working environment. To affect the documentation positively, a good communication and cooperation amongst the involved in the care, including the patient, where needed. Increased workload that lead to time constraints and stress complicated the work with diet and fluid records. Conclusion: The result of the study showed that the experience of diet records varies between individuals and different departments. The general perception was that the diet records were flawed but could be improved through different changes.

  • Edberg, Mathias
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Pedersen, Mattias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelse av postoperativ smärtlindring: En litteraturstudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Introduction: Pain is a complex and subjective experience, it is hard for any other else than the patient to understand it. All patients that undergo surgery will experience some sort of postoperative pain and therefore it is important to understand what pain is and what the patient goes through. Insufficient pain management could lead to postoperative complications that could be life threatening and increases the cost to society.

    Aim: The aim of this study was to examine the patient’s experiences of postoperative pain management.

    Methods: This study used a descriptive literature review. The searches were performed in the databases PubMed and CINAHL.

    Results: Results show that patients who were well-informed both pre- and postoperatively about the pain management were the most satisfied with their experience. Good communication and good treatment heightened the well-being of patients. Negative aspects could be communication difficulties and troubles describing the pain, lack of information and overstrained staff.

    Conclusion: The majority of patients were satisfied with their postoperative pain management but there were different things that had a negative influence on their experience. Improvements can be made, especially in the staffs’ individual behavior and in the organization as such.

  • Appel, Gabriella
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Becker Hjärp, Henrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Effekten av icke farmakologiska omvårdnadsåtgärder vid cancersmärta: En litteraturöversikt2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund

    Smärta är ett vanligt problem hos cancerpatienter. Upp till 55 % av alla cancerpatienter uppger att de har smärta trots att det får läkemedelsbehandling. Anledningen tros vara en kombination av att patienterna inte säger till i tid, samt att vårdpersonalen inte har tillräcklig kunskap om alternativa behandlingsmetoder.

    Syfte

    Syftet är att undersöka om icke farmakologiska omvårdnadsåtgärder har effekt vid cancersmärta.

    Metod

    En litteraturöversikt med deskriptiv design. Sammantaget var det 10 vetenskapliga originalartiklar som analyserades och sammanställdes i resultatet. Samtliga artiklar var randomiserade kontrollerade studier och söktes fram i PubMed, Cinahl eller Google Scholar.

    Resultat

    Resultatet visade att akupunktur, massage och TENS kan ha effekt på smärta. I artiklarna som inkluderades skiljde sig dosen, metoden och längden på interventionerna. De icke farmakologiska smärtlindringsmetoderna påverkade också deltagarnas livskvalitet då många upplevde en ångestlindring. Detta tros bero på en mellanmänsklig kontakt som upplevs som lugnande, vilket ger effekt på både psykisk och fysiologisk nivå.

    Slutsats

    Akupunktur, massage och TENS kan ha effekt på cancersmärta. Fler och större studier behöver dock utföras för att få ett större underlag för klinisk användning.

  • Johansson Martinelle, Cecilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Attityder till religiösa personbenämningar2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I denna studie kombineras språkvetenskap och religionsvetenskap i syfte att undersöka studenters undermedvetna språkattityder till tre religiösa personbenämningar: muslim(er), hindu(er) och kristen(-na). Deltagarna består av studenter över hela Sverige och majoriteten har könsidentitet kvinna samt är i åldern 15-25 år. Deltagarnas språkattityder undersöks genom en enkätundersökning med ett matched guise-test och semantisk differential. Resultaten tyder på att personbenämningen kristen(-na) ger upphov till fler negativa konnotationer än framförallt muslim(er) men även hindu(er). Muslimer rankas exempelvis som mer hänsynsfulla och intelligenta än kristna. Hinduer rankas exempelvis som mjuka medan kristna exempelvis rankas som mer dumma än hinduer och muslimer samtidigt som de rankas som hänsynsfulla och sympatiska. Attityderna till dessa tre personbenämningar verkar med andra ord följa ett trestegsmönster där personbenämningen muslim(er) skapar flest positiva konnotationer, tätt följd av hindu(er) och sist personbenämningen kristen(-na) som skapar positiva och negativa konnotationer.

  • Schaefer, Ingo
    et al.
    Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany.
    Hopchet, Manoelle
    Belgian Inst Psychotraumatol, Brussels, Belgium.
    Vandamme, Naomi
    Belgian Inst Psychotraumatol, Trauma Ctr Limburg, Hasselt, Belgium.
    Ajdukovic, Dean
    Univ Zagreb, Dept Psychol, Fac Humanities & Social Sci, Zagreb, Croatia.
    El-Hage, Wissam
    Univ Tours, CHRU Tours, INSERM, iBrain,UMR 1253, Tours, France.
    Egreteau, Laurine
    Clin Psychiat Univ, CHRU Tours, Laurine Egreteau, Tours, France.
    Javakhishvili, Jana Darejan
    ILia State Univ, Fac Arts & Sci, Inst Addict Studies, Tbilisi, Rep of Georgia.
    Makhashvili, Nino
    ILia State Univ, Business Sch, Tbilisi, Rep of Georgia.
    Lampe, Astrid
    Univ Med Hosp Innsbruck, Dept Med Psychol & Psychotherapy, Innsbruck, Austria.
    Ardino, Vittoria
    Urbino Univ, Dipartimento Sci Uomo, Urbino, Italy.
    Kazlauskas, Evaldas
    Vilnius Univ, Inst Psychol, Ctr Psychotraumatol, Vilnius, Lithuania.
    Mouthaan, Joanne
    Leiden Univ, Inst Psychol, Dept Clin Psychol, Leiden, Netherlands.
    Sijbrandij, Marit
    Vrije Univ Amsterdam, Fac Behav & Movement Sci, Amsterdam, Netherlands.
    Dragan, Malgorzata
    Univ Warsaw, Fac Psychol, Warsaw, Poland.
    Lis-Turlejska, Maja
    SWPS Univ Social Sci & Humanities, Fac Psychol, Warsaw, Poland.
    Figueiredo-Braga, Margarida
    Univ Porto, Fac Med, Porto, Portugal;Univ Coimbra, Ctr Social Studies CES, Coimbra, Portugal.
    Sales, Luisa
    Univ Coimbra, Ctr Trauma CES, Mil Hosp Coimbra, Dept Psychiat, Coimbra, Portugal.
    Arnberg, Filip
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, National Center for Disaster Psychiatry.
    Nazarenko, Tetiana
    USOCTE, Nongovt Org, Kiev, Ukraine.
    Nalyvaiko, Natalia
    USOCTE, Nongovt Org, Int Inst Depth Psychol, Kiev, Ukraine.
    Armour, Cherie
    Ulster Univ, Fac Life & Hlth Sci, Inst Mental Hlth Sci, Sch Psychol, Coleraine, Londonderry, North Ireland.
    Murphy, Dominic
    Combat Stress, Res Dept, Leatherhead, Surrey, England;Kings Coll London, Dept Psychol Med, Kings Ctr Mil Hlth Res, London, England.
    Trauma and trauma care in Europe2018In: European Journal of Psychotraumatology, ISSN 2000-8066, E-ISSN 2000-8066, Vol. 9, no 1, article id 1556553Article, review/survey (Refereed)
    Abstract [en]

    The European countries have a long history of exposure to large-scale trauma. In the early 1990s the increasing awareness of the consequences of trauma within the mental health community led to the foundation of local societies for psychotraumatology across Europe and the European Society of Traumatic Stress Studies (ESTSS), which celebrated its 25th anniversary in 2018. The focus of this article is to describe the current state of care for survivors of trauma in the 15 European countries where ESTSS member societies have been established. Brief descriptions on the historical burden of trauma in each country are followed by an overview of the care system for trauma survivors in the countries, the state-of-the-art of interventions, current challenges in caring for survivors and the topics that need to be most urgently addressed in the future. The reports from the different countries demonstrate how important steps towards a better provision of care for survivors of trauma have been made in Europe. Given the cultural and economic diversity of the continent, there are also differences between the European countries, for instance with regard to the use of evidence-based treatments. Strategies to overcome these differences, like the new ESTSS training curricula for care-providers across Europe, are briefly discussed.

  • Joel, Geier
    et al.
    Thatcher, Kate
    Newson, Rebecca
    Benbow, Steven
    Dessirier, Benoît
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Research on Resaturation of Bentonite Buffer2018Report (Other academic)
  • Georganaki, Maria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    van Hooren, Luuk
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer2018In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, article id 3081Article, review/survey (Refereed)
    Abstract [en]

    Boosting natural immunity against malignant cells has had a major breakthrough in clinical cancer therapy. This is mainly due to the successful development of immune checkpoint blocking antibodies, which release a break on cytolytic anti-tumor-directed T-lymphocytes. However, immune checkpoint blockade is only effective for a proportion of cancer patients, and a major challenge in the field is to understand and overcome treatment resistance. Immune checkpoint blockade relies on successful trafficking of tumor-targeted T-lymphocytes from the secondary lymphoid organs, through the blood stream and into the tumor tissue. Resistance to therapy is often associated with a low density of T-lymphocytes residing within the tumor tissue prior to treatment. The recruitment of leukocytes to the tumor tissue relies on up-regulation of adhesion molecules and chemokines by the tumor vasculature, which is denoted as endothelial activation. Tumor vessels are often poorly activated due to constitutive pro-angiogenic signaling in the tumor microenvironment, and therefore constitute barriers to efficient leukocyte recruitment. An emerging possibility to enhance the efficiency of cancer immunotherapy is to combine pro-inflammatory drugs with anti-angiogenic therapy, which can enable tumor-targeted T-lymphocytes to access the tumor tissue by relieving endothelial anergy and increasing adhesion molecule expression. This would pave the way for efficient immune checkpoint blockade. Here, we review the current understanding of the biological basis of endothelial anergy within the tumor microenvironment, and discuss the challenges and opportunities of combining vascular targeting with immunotherapeutic drugs as suggested by data from key pre-clinical and clinical studies.

  • Barazzoni, Rocco
    et al.
    Univ Trieste, Dept Med Surg & Hlth Sci, Internal Med, Trieste, Italy;Azienda Sanit Univ Integrata Trieste ASUITS, Trieste, Italy.
    Bischoff, Stephan
    Univ Hohenheim, Dept Nutr Med, Stuttgart, Germany.
    Boirie, Yves
    Univ Clermont Auvergne, UNH, INRA, Unite Nutr Humaine,CRNH Auvergne, Clermont Ferrand, France;CHU Clermont Ferrand, Serv Nutr Clin, Clermont Ferrand, France.
    Busetto, Luca
    Univ Padua, Dept Med, Padua, Italy;Padova Univ Hosp, Ctr Study & Integrated Management Obes EASO COM, Padua, Italy.
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Dicker, Dror
    Hasharon Hosp, Rabin Med Ctr, Dept Internal Med, Petah Tiqwa, Israel;Hasharon Hosp, Rabin Med Ctr, Obes Clin, Petah Tiqwa, Israel;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
    Toplak, Hermann
    Med Univ Graz, Dept Med, Graz, Austria.
    Van Gossum, Andre
    Free Univ Brussels, Hop Erasme, Dept Gastroenterol, Clin Intestinal Dis & Nutr Support, Brussels, Belgium.
    Yumuk, Volkan
    Istanbul Univ, Cerrahpasa Med Fac, Div Endocrinol Metab & Diabet, Istanbul, Turkey.
    Vettor, Roberto
    Univ Padua, Dept Med, Padua, Italy;Padova Univ Hosp, Ctr Study & Integrated Management Obes EASO COM, Padua, Italy.
    Sarcopenic Obesity: Time to Meet the Challenge2018In: Obesity Facts, ISSN 1662-4025, E-ISSN 1662-4033, Vol. 11, no 4, p. 294-305Article, review/survey (Refereed)
    Abstract [en]

    The prevalence of overweight and obesity has reached epidemic proportions worldwide due to increasingly pervasive obesogenic lifestyle changes. Obesity poses unprecedented individual, social, and multidisciplinary medical challenges by increasing the risk for metabolic diseases, chronic organ failures, and cancer as well as complication rates in the presence of acute disease conditions. Whereas reducing excess adiposity remains the fundamental pathogenic treatment for obese individuals, complex metabolic and lifestyle abnormalities as well as weight reduction therapies per se may also compromise the ability to preserve muscle function and mass, especially when chronic disease co-exists with obesity. Emerging evidence indicates that low muscle mass and quality have a strong negative prognostic impact in obese individuals and may lead to frailty, disability, and increased morbidity and mortality. Awareness of the importance of skeletal muscle maintenance in obesity is however low among clinicians and scientists. The term 'sarcopenic obesity' has been proposed to identify obesity with low skeletal muscle function and mass, but its utilization is largely limited to the aging patient population, and consensus on its definition and diagnostic criteria remains insufficient. Knowledge on prevalence of sarcopenic obesity in various clinical conditions and patient subgroups, on its clinical impacts in patient risk stratification, and on effective prevention and treatment strategies remain therefore dramatically inadequate. In particular, optimal dietary options and medical nutritional support strategies to preserve muscle mass in obese individuals remain largely undefined. The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) recognize and indicate obesity with altered body composition due to low skeletal muscle function and mass (sarcopenic obesity) as a scientific and clinical priority for researchers and clinicians. ESPEN and EASO therefore call for coordinated action aimed at reaching consensus on its definition, diagnostic criteria, and optimal treatment with particular regard to nutritional therapy. We are convinced that achievement of these goals has a strong potential to reduce the burden of morbidity and mortality in the rapidly increasing obese patient population.

  • Thorén, Matilda
    et al.
    Krumina, Agnese
    Fria pojkar och styrda flickor: En fälltstudie av pedagogens språkliga och kroppsliga bemötande av barn ur ett genusperspektiv2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio chemico-physica, de materiali differentia luminis et ignis, quam, suffrag. ampliss. ordin. philosoph. in academia Upsaliensi, moderante ... Joh. Gotschalk Wallerio ... pro gradu philosophico publico submittit examini Nicolaus Ol. Ullenius, Angermannus. In auditorio Gustav. ad diem XX Dec. anni MDCCLXVI, horis ante meridiem solitis.1766Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Kort afhandling om de mineraliske kroppars förvittring, i luften, med ampliiss. facult. phil. samtycke under ... Joh. Gotsch. Wallerii ... uti den Gustavianska lärosalen f.m.d. XVI Maji ann. MDCCLXVI. ... ompröfvande framsteld af stipendiarius Ahlöfvianus Anders Nejman Andersson, vestmanlänning.1766Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Dissertatio chemico-pharmaceutica, de differentia et examine oleorum, quam indultu nobil. atque exper. ord. med. in illustri lyceo Upsaliensi, præside ... Johan. Gotsch. Wallerio ... publice ventilandam sistit Henric. Schultz, Henricsson, Stockholmiensis. In auditorio Gustaviano d. XIX Junii. Anni MDCCLXV H. a. m. c.1765Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Kort afhandling, om nyttan af malmernas råstning, med ampliss. facult. phil. samtycke, under ... Johan Gotsch. Wallerii ... uti den gustavianska lärosalen, d. [XVIII] junii ann. MDCCLXV. Vid kongl. academien i Upsala utgifven och till almänt ompröfvande framstäld, af Gustav Fries, nerkesbo1765Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de natura et indole montium diversa, quam suffrag. ampliss. facult. philosoph. in illustri academica Upsaliensi, sub præsidio ... Joh. Gotschalk Wallerii ... publicæ disquisitioni submittit Olaus Ol. Omnberg, Angermannus. In audit. Gustav. die XXIV. April. anni MDCCLXV. Horis ante meridiem solitis.1765Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de unguento nardino pretioso, quam, suffrag. ampliss. ordin. philosoph. in illustri academia Upsaliensi, præside ... Joh. Gotschalk Wallerio ... in audit. Gustav. die VIII Junii. Horis post meridiem solitis. anni MDCCLXIV, publico examini modeste subjicit Ericus Joh. Huss, senior, Jemtlandus.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis de convenientia macrocosmi et microcosmi. Quam, consent. ampliss. facult. philosoph. in reg. academia Upsaliensi, sub præsidio ... Johannis Gotsch. Wallerii ... publico examini modeste defert Laurentius Carlmark, Westro-Gothus. In aud. Gustaviano die XII Junii Anni MDCCLXIV. H. a. m. s.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.
    Dissertatio chemico-pharmaceutica, de incongrua medicamentorum mixtura, quam, ex consensu nobil. et exper. eac. med. in regia academia Upsaliensi, præside ... Joh. Gotschalk Wallerio ... publice ventilandam exhibet, Joh. Frid. Wertmüller, Stockholmiensis. In audit. Gustaviano die [tomrum] Junii, anni MDCCLXIV. Horis antemeridianis solitis.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio chemico physica, de diversis ignem producendi modis, quam, suffragio ampliss. senatus philosoph. in academia Upsaliensi, moderante ... Joh. Gotschalk Wallerio ... in auditorio Gustaviano anni ad. sal. MDCCLXIV die VII Junii. H. a. m. s. pro gradu philosophico publice ventilandam exhibet stipendiarius regius Laurent. Ekmarck Laur. fil. Nericius.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertationem physico-chemicam, de spiritu mundi, venia amplissimi ordinis philosoph. in regia academia Upsaliensi, præside ... Joh. Gotsch. Wallerio ... pro gradu philosophico, publico examini defert Ericus Er. Östling, Gestricius. In auditorio Gustaviano ad diem [tomrum] Junii anni MDCCLXIV. Horis ante meridiem solitis.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de virgula divinatoria, quam, consentiente ampliss. senatu. philos. in reg. adademia Upsaliensi, præside ... Johan. Gotsch. Wallerio ... publice ventilandam sistit Petr. Adolph. Ahlbom, Gestricius. In auditorio Gustaviano d. [tomrum] Junii a. o. r. MDCCLXIV. Horis post meridiem consuetis.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, sistens indolem historiæ naturalis in genere, quam, suffrag. ampliss. ordin. philosoph. in regia academia Upsaliensi, præside ... Joh. Gotsch. Wallerio ... publico examini modeste submittit alumnus regius Laurentius Lyth. Gothlandus. In auditorio Carol. maj. d. [tomrum] Junii anni MDCCLXIV. Horis ante meridiem solitis.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de divitiis in arena ad dictum Deut. XXX III. v.19. quam, suffrag. ampliss. ordin. philosoph. in illustri academia Upsaliensi, præside ... Joh. Gotschalk Wallerio, ... in audit. Gustav. die [tomrum ] Junii horis [tormum] meridiem solitis anni MDCCLXVIV. Publico examini modeste submittit stipendiarius regius Christophorus Borg, Westmannus.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de quadruplici regno naturæ, quam, venia amplissimi ord. philos. in illustri athenæo Upsaliensi, præside ... Joh. Gotschalk Wallerio ... in audit. Gustav. d. [tomrum] Junii anni MDCCLXIV. Horis ante meridiem consvetis. Pro solitis in philosophia honoribus publicæ censuræ committit alumnus regius Johannes Möller, Sudermannus.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis de sacro igne quam, venia amplissimi ordinis philosoph. in inclyto, ad salam Svionum, Lyceo, et praeside, viro amplissimo celeberrimo, d:o Joh. Gotschalk Wallerio, ... In audit. Gustav. ad diem [tomrum] Junii anni MDCCLXIV. Horis ante meridiem consvetis, publico examini offert s:æ r:æ m:tis stipendiarius Andreas Ericus Barwander Sudermannus.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio chemico-physica, de Palingenesia, quam, suffragio ampliss. ord. philosoph. in regia academia Upsaliensi, præside ... Joh. Gotschalk Wallerio ... pro gradu philosophico, publicæ disquisitioni committit Gerhardus Reinh. Höjer, Orebrogia Nercicius. In audit. Gustav. die [tomrum] anni MDCCLXIV. Horis ante meridiem solitis,1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, brevi adumbrans colles ad Uddewalliam conchaceos quam, ad illustre Upsal. athenæum adsent. ampliss. ord. philosophico, præside ... Joh. Gotschalk Wallerio ... in auditorio Gustav. die XXVII April. Horis ante meridiem consvetis, anni MDCCLXIV. Publico examini defert, pro gradu, Olavus Bruhn, Gothoburgensis.1764Dissertation (older thesis) (Other academic)
  • Wallerius, Johan Gottschalk
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertationem chemico physicam de statu aquæ naturali, moderante ... Johan. Gotsch. Wallerio ... in audit. Gust. ad diem [tomrum] Martii anni MDCCLXIV. Horis ante merid. solitis, pro gradu philosophico, eruditorum examini submittit s:æ r:æ m:tis alumnus Petrus Grawallius, Nericius1764Dissertation (older thesis) (Other academic)
  • Xie, Ruiwen
    et al.
    Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.
    Li, Wei
    Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.
    Lu, Song
    Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.
    Song, Yan
    Harbin Inst Technol Weihai, Sch Mat Sci & Engn, Weihai 264209, Peoples R China.
    Vitos, Levente
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden; Inst Solid State Phys & Opt, Wigner Res Ctr Phys, Budapest, Hungary.
    Generalized stacking fault energy of carbon-alloyed paramagnetic gamma-Fe2019In: Journal of Physics: Condensed Matter, ISSN 0953-8984, E-ISSN 1361-648X, Vol. 31, no 6, article id 065703Article in journal (Refereed)
    Abstract [en]

    Generalized stacking fault energy (GSFE) is an important parameter for understanding the underlying physics governing the deformation mechanisms in face-centred cubic (fcc) materials. In the present work, we study the long-standing question regarding the influence of C on the GSFE in austenitic steels at paramagnetic state. We calculate the GSFE in both gamma-Fe and Fe-C alloys using the exact muffin-tin orbitals method and the Vienna Ab initio Simulation Package. Our results show that the GSFE is increased by the presence of interstitial C, and the universal scaling law is used to verify the accuracy of the obtained stacking fault energies. The C-driven change of the GSFE is discussed considering the magnetic contributions. The effective energy barriers for stacking fault, twinning and slip formation are employed to disclose the C effect on the deformation modes, and we also demonstrate that the magnetic structures as a function of volume explain the effect of paramagnetism on the C-driven changes of the stacking fault energies as compared to the hypothetical non-magnetic case.

  • Bergvall, Olof
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Cohomology of the toric arrangement associated with A(n)2019In: Journal of Fixed Point Theory and Applications, ISSN 1661-7738, E-ISSN 1661-7746, Vol. 21, no 1, article id 15Article in journal (Refereed)
    Abstract [en]

    We compute the total cohomology of the complement of the toric arrangement associated with the root system An as a representation of the corresponding Weyl group via fixed point theory of a twisted action of the group. We also provide several proofs of an explicit formula for the Poincare polynomial of the complement of the toric arrangement associated with An.

  • Morgan, Andrew J.
    et al.
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Univ Melbourne, Sch Phys, ARC Ctr Excellence Adv Mol Imaging Sch Phys, Parkville, Vic 3010, Australia.
    Ayyer, Kartik
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Max Planck Inst Struct & Dynam Matter, Luruper Chaussee 149, D-22761 Hamburg, Germany;Ctr Free Electron Laser Sci, Luruper Chaussee 149, D-22761 Hamburg, Germany.
    Barty, Anton
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
    Chen, Joe P. J.
    Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA.
    Ekeberg, Tomas
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics. Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
    Oberthuer, Dominik
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
    White, Thomas A.
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
    Yefanov, Oleksandr
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
    Chapman, Henry N.
    Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22761 Hamburg, Germany;Ctr Ultrafast Imaging, Luruper Chaussee 149, D-22761 Hamburg, Germany.
    Ab initio phasing of the diffraction of crystals with translational disorder2019In: ACTA CRYSTALLOGRAPHICA A: FOUNDATION AND ADVANCES, ISSN 2053-2733, Vol. 75, p. 25-40Article in journal (Refereed)
    Abstract [en]

    To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined against the set of observed Bragg reflections from a protein crystal. The resolution of the refined protein structure is limited by the highest angle at which Bragg reflections can be observed. In addition, the Bragg reflections alone are typically insufficient (by a factor of two) to determine the structure ab initio, and so prior information is required. Crystals formed from an imperfect packing of the protein molecules may also exhibit continuous diffraction between and beyond these Bragg reflections. When this is due to random displacements of the molecules from each crystal lattice site, the continuous diffraction provides the necessary information to determine the protein structure without prior knowledge, to a resolution that is not limited by the angular extent of the observed Bragg reflections but instead by that of the diffraction as a whole. This article presents an iterative projection algorithm that simultaneously uses the continuous diffraction as well as the Bragg reflections for the determination of protein structures. The viability of this method is demonstrated on simulated crystal diffraction.

  • Andén (fd. Håkansson), Lovisa
    Södertörn University.
    Le Monde Sensible Et Le Monde De L'Expression, Maurice Merleau-Ponty, eds. Emmanuel de Saint Aubert and Stefan Kristensen2013In: Journal of the British Society for Phenomenology, ISSN 0007-1773, E-ISSN 2332-0486, Vol. 44, no 1, p. 105-109Article, book review (Other academic)