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  • Erenbo, Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Heavy metal removal and water treatment using Upsalite2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Ion exchange reactions between Upsalite, a mesoporous magnesium carbonate, and metal ions of cadmium, lead and nickel have been studied to evaluate the capacities of Upsalite as a water treatment agent. Uptake capacity and reaction kinetics have been evaluated using a batch experiment and atomic absorption spectroscopy. Post reaction materials from the reaction between Upsalite and each of the three metal ions have been investigated with XRD, SEM and TGA in order to determine what species have been formed during the ion exchange.

     

    The maximum uptake capacity of Upsalite was found to be 990 mg/g for cadmium ions and 470 mg/g for nickel ions. The evaluation of the uptake capacity of lead ions in Upsalite was not conclusive but the results indicate a maximum uptake capacity of at least 4400 mg/g. The uptake capacity for lead ions is to high be explained by ion exchange alone and is proposed to be from both ion exchange and adsorption. The reaction between Upsalite and cadmium ions resulted in the formation of crystalline CdCO3 (Otavite) with some parts of MgCO3 and crystalline MgO remaining from the original material. Post reaction materials from the reaction between nickel ions and Upsalite were found to be amorphous and contained both MgCO3 and crystalline MgO. The reaction between Upsalite and lead ions resulted in crystalline hydrocerussite (Pb3(CO3)2(OH)2).

  • Murto, Tiina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Yngve, Agneta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Skoog Svanberg, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Altmäe, Signe
    Competence Ctr Hlth Technol, Tartu, Estonia.
    Salumets, Andres
    Competence Ctr Hlth Technol, Tartu, Estonia;Univ Tartu;Univ Helsinki;Helsinki Univ Hosp.
    Wånggren, Kjell
    Karolinska Inst.
    Stavreus-Evers, Anneli
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Compliance to the recommended use of folic acid supplements for women in Sweden is higher among those under treatment for infertility than among fertile controls and is also related to socioeconomic status and lifestyle2017In: Food & Nutrition Research, ISSN 1654-6628, E-ISSN 1654-661X, Vol. 61, 1334483Article in journal (Refereed)
    Abstract [en]

    Background: Folate has been discussed in relation to fertility among women, but studies on women under treatment for infertility are lacking.

    Objective: The objective of this study was to investigate folic acid supplement use and folate status among women under treatment for infertility (hereafter infertile) and fertile women also in regard to socioeconomic and lifestyle factors.

    Design: Lifestyle and dietary habits, and use of dietary supplements were assessed using a questionnaire. Blood samples were obtained for analysis of folate status. 24-hour recall interviews were also performed.

    Results: Highly educated, employed and infertile women were most prone to using folic acid supplements. The infertile women had a significantly better folate status than the fertile women. Folate status did not correlate with socioeconomic or lifestyle factors. The infertile women were physically more active, smoked less and were employed. Our questionnaire data had only fair agreement with the data from 24-hour recalls, but the folate status data was clearly correlated to our questionnaire results.

    Conclusions: Infertile women were most prone to using folic acid supplements and had better folate status than the controls. High educational and employment status were found to be key factors for high compliance to the recommended use folic acid supplements.

  • Maaroufi, Semeh
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Asad, Amna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Leadership Style & Challenges of MCT Management: Case Study- Swedish Construction MNC2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Ongoing globalization in business world has led to increase diversity of workforce.Organizations are relying more and more on people coming from all over the world withdifferent backgrounds, nationalities, culture, race etc. Operating in such multiculturalenvironment has forced MNCs to recognize the importance of retaining highly qualified leadersto manage multicultural employees and more specifically to pay attention on the differentchallenges that they might face. In such multicultural environment, it’s important that managershave the required competencies to manage people from culturally diverse background.The purpose of this study is to investigate in detail the most suitable leadership styles toovercome the challenges of multicultural project teams so that organizations can gaincompetitive advantage over others. To find the most suitable leadership styles, firstly weinvestigated based on literature the most important challenges and issues that both projectmanagers and multicultural teams face. Secondly, we defined the project managers who areable to identify and overcome the challenges of multicultural teams. Thirdly, we analysed theleadership style and competencies of project managers who are aware of the differentchallenges of MCT to find out the most suitable and common leadership style in the studiedindustry. The research is a qualitative single case study focusing on one construction MNCnamely ‘Skanska’ in Sweden.In this study, we found three common leadership styles presented among project managersnamely; mix of servant plus transformational leadership, mix of transformational andtransactional leadership, and lastly transformational leadership style. Findings from the studyshow that mix of servant and transactional leadership is the most suitable leadership style formanaging multicultural project teams in construction industry, while it seems also thattransformational leadership style is being the most common style as every project leaderpossess some traits of it.

  • Axelsson, Julius
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ulander, Emil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Does pay dispersion affect firm performance?: A study of publicly traded Swedish firms2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates the short and long-term effects of pay dispersion on firm performance in publicly listed Swedish firms. Pay dispersion refers to the difference in compensation between or within organizational levels. There are two contradicting theoretical views of pay dispersions effect on firm performance. While tournament theory suggests that high pay dispersion increase employees’ incentives to exert higher effort, thus increasing firm performance, fairness approaches predicts that high pay dispersion creates feelings of unfairness, thus negatively affecting firm performance. Based on these theories and previous research, Hypothesis 1 predicts a positive short-term effect of pay dispersion on firm performance, and Hypothesis 2 predicts a negative long-term effect of pay dispersion on firm performance. Using a first differences fixed-effects regression including controls for firm characteristics and corporate governance indicators, three measures of pay dispersion are tested on two proxies for firm performance (price to book and return on assets). We conclude after extensive robustness tests that pay dispersion has no effect on firm performance, neither on short nor on long-term. Therefore, both hypotheses are rejected.

  • Hansson, Fanny
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Hellholm, Matilda
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Utbildning och kravställning i Norra Djurgårdsstaden: Ett hjälpmedel för hållbart byggande2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Stockholm Royal Seaport is one of Europe´s largest urban development projects. The city of Stockholm has ambitious environmental goals and a vision for Stockholm Royal Seaport to develop into a world-class environmental urban district. In order to achieve the aspiring goals, requirements are set in the agreement with property developers with land allocation. The city of Stockholm offers a capacity development programme to assure fulfilling of the requirements and simultaneously educate the property developers.

    The aim of this thesis is to examine how the requirements and capacity development programme in Norra 2, the third leg in the development of Stockholm Royal Seaport, has contributed to spreading knowledge among property developers. The thesis is limited to investigation energy requirements. With focus on the technical solutions used to obtain a low energy usage and what the developers will carry on to future projects.

    The analysis indicates that the capacity development programme has a positive effect on the developers´s collaboration to achieve more sustainable buildings. Strict verifying of the requirements has been a contributing factor to the positive results in Stockholm Royal Seaport. Several technical solutions are incorporated in the buildings in order to meet the requirements of energy savings. This leads to advanced systems that are difficult to manage and has beeenan issue fort the developers. Another issue is ambiguous and contradictory requirements that according to the developers has taken a consideralble amount of time and resources to fulfil. Setting requirements is important in developing more sustainable buildings. If demans are not made a lot of companies will chose the cheap and simple way to maximize profits. Continuing setting requirements and having a dialouge between stakeholders in an eraly stage is essential for a continuing sustainable development.  

  • Eriksson, Christoffer
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Thermal design optimization by geometric parameterization of heat sources2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this master thesis, a thermal design optimization has been performed. By solvingthe two dimensional steady state conduction convection equation using the finiteelement method in a unit square domain with a source term corresponding tocomponents heated by resistive heating, the objective functional was formulated as aminimization of the combination of a low temperature and small temperaturedifferences inside the domain. The design parameters are based on geometricproperties such as length, width, angle or position of the heat sources. The heatsources were parameterized by combining two smooth exponential functions thatexplicitly depended on the position and size of the heat source. The problem wasthen solved as a PDE constrained optimization problem using MATLAB's built infunction fmincon.

    Three different 1D test cases were implemented to investigate how the solverbehaved and that the parameterization was correctly implemented. Then the solverwas extended to 2D and three heat sources were placed in the domain. The optimalangle of rotation of the sources where the heat transfer was governed by conductionand convection were found. This was followed by an optimal placement of two heatsources in the domain. Three cases with a different convective field in each case wereinvestigated. In the last examples, four heat sources were placed inside the domain.One geometric property of each heat source was allowed to change. The fourdifferent parameters were length, width, angle of rotation and position. Themotivation was to test the functionality of the solver using different design parameterswith different sensitivities.

    The results showed that the derived objective functional fullfilled the purpose tominimize the temperature and temperature deviation from the mean temperature,respectively. In the 1D cases it was concluded that there exist several local minimawhen adding a heat source and a heat sink of unequal magnitude. Optimal angles ofthree heat sources in 2D showed a trivial solution and fast convergence. The optimalplacement of two heat sources converged rapidly when the forced convection was setto zero. When adding convection the number of iterations increased and the optimalplacement was highly dependent of the type of convective field and boundaryconditions. When constructing a non symmetric problem the optimization loopedover several random initial positions in order to find the best optimal solution. Forthe last examples, narrow bounds were used and the solver converged rapidly. Evenhere, the type of convective field highly affected the optimal solution.

  • Herziger, Atar
    et al.
    Univ Cologne, Cologne Grad Sch Management Econ & Social Sci, Cologne, Germany..
    Benzerga, Amel
    UCL, Div Psychol & Language Sci, London, England..
    Berkessel, Jana
    Univ Cologne, Dept Psychol, Cologne, Germany..
    Dinartika, Niken L.
    Maastricht Univ, Dept Psychol, Maastricht, Netherlands..
    Franklin, Matija
    Univ Cambridge, Dept Psychol, Cambridge, England..
    Steinnes, Kamilla K.
    Univ Oslo, Dept Psychol, Oslo, Norway..
    Sundström, Felicia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    A Study Protocol for Testing the Effectiveness of User-Generated Content in Reducing Excessive Consumption2017In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 8, 972Article in journal (Refereed)
    Abstract [en]

    Excessive consumption is on the rise, as is apparent in growing financial debt and global greenhouse gas emissions. Voluntary simplicity, a lifestyle choice of reduced consumption and sustainable consumer behavior, provides a potential solution for excessive consumers. However, voluntary simplicity is unpopular, difficult to adopt, and under researched. The outlined research project will test a method of promoting voluntary simplicity via user-generated content, thus mimicking an existing social media trend (Minimalism) in an empirical research design. The project will test (a) whether the Minimalism trend could benefit consumers interested in reducing their consumption, and (b) whether self-transcendence (i.e., biospheric) and self-enhancement (i.e., egoistic and hedonic) values and goals have a similar impact in promoting voluntary simplicity. A one-week intervention program will test the efficacy of watching user-generated voluntary simplicity videos in reducing non-essential consumption. Each of the two intervention conditions will present participants with similar tutorial videos on consumption reduction (e.g., decluttering, donating), while priming the relevant values and goals (self-transcendence or self-enhancement). These interventions will be compared to a control condition, involving no user-generated content. Participants will undergo baseline and post intervention evaluations of: voluntary simplicity attitudes and behaviors, buying and shopping behaviors, values and goals in reducing consumption, and life satisfaction. Experience sampling will monitor affective state during the intervention. We provide a detailed stepwise procedure, materials, and equipment necessary for executing this intervention. The outlined research design is expected to contribute to the limited literature on voluntary simplicity, online behavioral change interventions, and the use of social marketing principles in consumer interventions.

  • Thorell, Jacob
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sjöstrand, Jesper
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Through the Eyes of a Manager: A study on the perceived effects of PSD2 and the preparatory work of Swedish bank managers2017Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The European financial market is rapidly changing with emerging fintechs targeting the banks’ traditional value chain, leveraging on their lower pace of innovation. The Payment Services Directive 2 (PSD2) is put into force in 2018 and aims to open up the financial market to new competitors, thus, promoting positive competition. This study examines how the managerial perception of changes in the external environment, caused by PSD2, affects banks’ preparatory work. The study uses a mix of Market Based View and Resource Based View along with an extension of RBV, illuminating how capabilities and managerial cognition affects managerial action. Using a qualitative approach through an interview based comparison between managers of two Swedish banks, the study confirms the theories’ stating that managerial cognition of the external environment, comprised of perceived opportunities and threats, affects managerial preparatory actions. Additionally, the study shows that managers’ perception of organisational capabilities affects managerial action.

  • Ideström, David
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    International Entrepreneurship: A Capabilities Perspective on Opportunity Identification and Exploitation2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study aims to explore what capabilities that are involved in the formation and early performance of firms that internationalize in an early stage of their development. More specifically, the antecedents of identification and exploitation of business opportunities are explored and linked to specific capabilities. For this purpose, an exploratory-inductive case study is employed to allow for new capabilities to be identified. The analyzed data largely confirms the insights already reached in academic research, in particular the centrality of networking capability in the process of entrepreneurship. As for international business opportunities, the study highlights the importance of creating opportunities to meet with prospective international customers and suggests the importance of absorbing knowledge about these markets so as to reduce cultural distance. The main virtue of this study though, is that it provides a practice-oriented perspective on the process of international entrepreneurship.

  • Dogan Bozan, Berivan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Arefaine, Bana
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    The implementation of ISA 701-key audit matters:: Empirical evidence on auditors adjustments in the new audit report2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The previous audit report gained a lot of criticism since it contained to much standard text that failed to convey valuable information for users. This lead to IAASB implementing a new standard, called ISA 701-KAM, which was implemented by all listed companies in the end of 2016. The purpose of KAM is to make the audit report less standardized and instead provide transparent and entity-specific information. However, there are those who believe that the confidentiality duty, which is prerequisite to be able to perform an audit, can stand in contrast to the new standard.  In order to investigate this issue, we have interviewed auditors to get their view of how they have implemented and applied KAM in the audit report. Our results show that auditors are skeptical in regards to the audit report being as entity-specific and transparent as IAASB expect it to be, since there exist an underlying fear of overstepping TCD. 

  • Hermansson, Natalie
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Gertz, Philip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Empowerment som styrmedel: En kvalitativ studie på en svensk storbank2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Customer satisfaction in banks has fallen sharply in 2016. Banks are subject to laws and regulations and can be expected to have a strict working approach. In line with new digital devices, banks tries to find new ways to create a loyal customer relationship. Previous research has shown a link between empowerment and customer satisfaction and therefore constitutes an interesting topic. The study intends to investigate whether banks aim to increase empowerment at their local employees. Through a survey of how employees perceive governance in a bank, the study can contribute with the insight that empowerment is something that is applied to governance.

    Through a qualitative case study, the result has been analyzed using the analysis model and assumes an abductive approach. The analysis model has been applied to six semistructured interviews from individuals of different age, sex and position. The study shows indications that empowerment is used as an instrument of governance at a local level in the bank.

  • Mucollari, Lorela
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Samokhin, Vasily
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Gamification: The influence of gamification on the consumer purchase intention2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Gamification is the new strategy that is applied in different areas from healthcare to the education, it is gaining a lot of popularity. Gamification is applied also in the online retailing, for trying to influence the consumer behavior. In this research paper Steam is going to be taken as a case study, since the platform is gamified. The aim of the study is to understand how gamification can influence the consumer behavior in the online retailing. As a main theoretical framework, the Fogg behavioral model. The main variables of the model are motivation, ability and trigger. In specific how the gamification can prompt the human motivation. In order to answer to the research question qualitative and quantitative research has been conducted. The qualitative research was conducted by interviewing users of the platform. While the quantitative research was conducted using a survey. The interviews and the regression model showed that extrinsic and intrinsic motivation play an important role in influencing the purchase intention of the users. According to our findings gamification influence the purchase intention by prompting the motivation of the users and at the same time also ability does influence positively the purchase intention.

  • Nordgren, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Att organisera kunskap: En fallstudie om kunskapsdelning i teori och praktik2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Knowledge sharing has been gaining more interest over the past decades, and is being recognized as an opportunity to gain a competitive advantage for organisations. While knowledge sharing has been gaining more attention, knowledge itself has begun to be considered a valuable resource and some researchers even consider it to be a vital part of innovation, which is also suggested to be a sustainable source of competitive advantage for companies. One would think that this is enough incentive to drive any company executive to pursue effective knowledge sharing initiatives, but a pilot-study for this paper suggests that this is not necessarily the case.

    Some researchers suggest that there is a vagueness surrounding the field of knowledge management and knowledge sharing. They also suggest that this is the reason as to why so many companies struggle to have success with their knowledge sharing initiatives. The aim of this study is therefore to examine the vagueness and complexity surrounding knowledge sharing. The results of this study implies that this vagueness might be somewhat exaggerated, seeing that the company examined in this study seems to implement and execute some of the most cited theories in the field quite successfully.

  • Holm, Martin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Lantz, Max
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    IFRS 13 och dess upplysningskrav: En studie om regelefterlevnad på Nasdaq Helsinki och Nasdaq Stockholm2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studien undersöker till vilken grad företag som är noterade på Nasdaq Helsinki och Nasdaq Stockholm inom bank-, fastighets- och skogsbranschen följer upplysningskraven för tillgångar värderade till verkligt värde enligt IFRS 13. Flera oberoende variabler kontrolleras om de har någon påverkan på regelefterlevnaden. Variablerna som undersöks är skuldsättning, företagsstorlek, bransch, kontrollorgan samt lärande. Data insamlas genom bearbetning av företagens årsredovisningar. Efterlevnaden av upplysningskraven sammanställs i ett index som visar på en total regelefterlevnad på 93,32%. Av de oberoende variablerna är det endast bransch som har en signifikant påverkan på regelefterlevnaden. Det är banksektorn som visar sig ha ett negativt samband med efterlevnaden av upplysningskraven i IFRS 13. Storlek visar en indikation på ett positivt samband medan övriga variabler inte visar på något samband alls.

  • Gustavsson, Johan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Winnberg, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Vad motiverar redovisning av effekter utanför ledningens kontroll: En studie av kvartalsrapporter2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Kvartalsrapporter är till skillnad från årsredovisningar oreviderade vilket innebär att företag själva har möjlighet att välja vad de vill redovisa. Många tidigare studier visar starka samband mellan frivillig redovisning och lönsamhet och storlek. Syftet med studien är att besvara problemformuleringen: I vilken utsträckning är ett företags lönsamhet och storlek kopplat till redovisning av sin exponering till faktorer utanför ledningens kontroll? Den teoretiska bakgrunden grundas i agent-, legitimitets- och signaleringsteorin som tillsammans används för hypotesformulering. Metoden som används är en insamling av primärdata ur kvartalsrapporter för svenska börsnoterade företag under åren 2005-2016, vars data analyseras med hjälp av ordinala regressioner. I resultatet presenteras deskriptiv statistik först, därefter presenteras resultatet regressionsvis. Studien finner belägg för att det inte finns något samband mellan storlek och grad av frivillig redovisning vilket skiljer sig från tidigare studier. Studiens resultat om lönsamhet och frivillig redovisning är ej signifikant.

  • Perez-Cornago, Aurora
    et al.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Appleby, Paul N.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Tsilidis, Konstantinos K.
    Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Tjonneland, Anne
    Danish Canc Soc Res Ctr, Copenhagen, Denmark..
    Olsen, Anja
    Danish Canc Soc Res Ctr, Copenhagen, Denmark..
    Overvad, Kim
    Aarhus Univ, Sect Epidemiol, Dept Publ Hlth, Aarhus C, Denmark..
    Katzke, Verena
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany..
    Kuehn, Tilman
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany..
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Med Sch, Unit Nutr Epidemiol & Nutr Publ Hlth,WHO, Collaborating Ctr Nutr & Hlth,Dept Hyg Epidemiol, Athens, Greece..
    Peppa, Eleni
    Hellen Hlth Fdn, Athens, Greece..
    Kritikou, Maria
    Hellen Hlth Fdn, Athens, Greece..
    Sieri, Sabina
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy..
    Palli, Domenico
    Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy..
    Sacerdote, Carlotta
    Univ Turin, AO Citta Salute & Sci, Unit Canc Epidemiol, Turin, Italy.;Ctr Canc Prevent CPO Piemonte, Turin, Italy..
    Tumino, Rosario
    Civ MP Arezzo Hosp ASP Ragusa, Canc Registry & Histopathol Unit, Ragusa, Italy..
    Bueno-de-Mesquita, H. B. (as)
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands.;Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia..
    Agudo, Antonio
    Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain..
    Larranaga, Nerea
    Reg Govt Basque Country, Publ Hlth Div Gipuzkoa, Vitoria, Spain.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain..
    Molina-Portillo, Elena
    CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Univ Granada, Hosp Univ Granada, GRANADA, Escuela Andaluza Salud Publ,Inst Invest Biosanita, Granada, Spain..
    Ardanaz, Eva
    CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res IdiSNA Pamplona, Pamplona, Spain..
    Chirlaque, Maria-Dolores
    CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain..
    Lasheras, Cristina
    Univ Oviedo, Fac Med, Dept Funct Biol, Asturias, Spain..
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
    Wennberg, Maria
    Umea Univ, Nutr Res, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Drake, Isabel
    Lund Univ, Dept Clin Sci Malmo, Diabet & Cardiovasc Dis Genet Epidemiol, Lund, Sweden..
    Malm, Johan
    Lund Univ, Skane Univ Hosp, Dept Translat Med Clin Chem, Malmo, Sweden..
    Schmidt, Julie A.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Khaw, Kay-Tee
    Univ Cambridge, Sch Clin Med, Cambridge, England..
    Gunter, Marc
    Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France..
    Freisling, Heinz
    Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France..
    Huybrechts, Inge
    Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France..
    Aune, Dagfinn
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Cross, Amanda J.
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England..
    Key, Timothy J.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England..
    Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)2017In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 141, no 2, 287-297 p.Article in journal (Refereed)
    Abstract [en]

    Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up time of 13.9 years, 7,036 prostate cancer cases were identified. Compared with the lowest fifth, those in the highest fifth of total fruit intake had a significantly reduced prostate cancer risk (HR = 0.91; 95% CI = 0.83-0.99; p-trend = 0.01). No associations between fruit subtypes and prostate cancer risk were observed, except for citrus fruits, where a significant trend was found (HR = 0.94; 95% CI = 0.86-1.02; p-trend = 0.01). No associations between total and subtypes of vegetables and prostate cancer risk were observed. We found no evidence of heterogeneity in these associations by tumor grade and stage, with the exception of significant heterogeneity by tumor grade (p(heterogeneity)<0.001) for leafy vegetables. No significant associations with prostate cancer death were observed. The main finding of this prospective study was that a higher fruit intake was associated with a small reduction in prostate cancer risk. Whether this association is causal remains unclear. What's new? The role of diet in prostate-cancer etiology is uncertain, and associations may vary by tumor characteristics. In this prospective, longitudinal study, the authors examined the association of total and subtypes of fruit and vegetable intake with the overall incidence of prostate cancer. They then analyzed incidence by grade, stage of disease, and prostate-cancer death. They found that higher fruit intake was associated with a small reduction in prostate cancer risk, and that this association did not differ by tumor characteristics.

  • Stattin, Pär
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden..
    Sandin, Fredrik
    Uppsala Univ Hosp, Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden..
    Thomsen, Frederik Birkebk
    Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark..
    Garmo, Hans
    Uppsala Univ Hosp, Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.;Kings Coll London, Sch Med, Div Canc Studies, Canc Epidemiol Grp, London, England..
    Robinson, David
    Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.;Ryhov Hosp, Dept Urol, Jonkoping, Sweden..
    Lissbrant, Ingela Franck
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden..
    Jonsson, Hakan
    Umea Univ, Dept Radiat Sci, Umea, Sweden..
    Bratt, Ola
    Lund Univ, Div Urol Canc, Dept Translat Med, Lund, Sweden.;Cambridge Univ Hosp, Dept Urol, CamPARI Clin, Cambridge, England..
    Association of Radical Local Treatment with Mortality in Men with Very High-risk Prostate Cancer: A Semiecologic, Nationwide, Population-based Study2017In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 72, no 1, 125-134 p.Article in journal (Refereed)
    Abstract [en]

    Background: Current guidelines recommend androgen deprivation therapy only for men with very high-risk prostate cancer (PCa), but there is little evidence to support this stance. Objective: To investigate the association between radical local treatment and mortality in men with very high-risk PCa. Design, setting, and participants: Semiecologic study of men aged < 80 yr within the Prostate Cancer data Base Sweden, diagnosed in 1998-2012 with very high-risk PCa (local clinical stage T4 and/or prostate-specific antigen [PSA] level 50-200 ng/ml, any N, and M0). Men with locally advanced PCa (local clinical stage T3 and PSA level < 50 ng/ml, any N, and M0) were used as positive controls. Intervention: Proportion of men who received prostatectomy or full-dose radiotherapy in 640 experimental units defined by county, diagnostic period, and age at diagnosis. Outcome measurements and statistical analysis: PCa and all-cause mortality rate ratios (MRRs). Results and limitations: Both PCa and all-cause mortality were half as high in units in the highest tertile of exposure to radical local treatment compared with units in the lowest tertile (PCa MRR: 0.51; 95% confidence interval [CI], 0.28-0.95; and all-cause MRR: 0.56; 95% CI, 0.33-0.92). The results observed for locally advanced PCa for highest versus lowest tertile of exposurewere in agreement with results fromrandomized trials (PCaMRR: 0.75; 95% CI, 0.60-0.94; and all-cause MRR: 0.85; 95% CI, 0.72-1.00). Although the semiecologic design minimized selection bias on an individual level, the effect of high therapeutic activity could not be separated from that of high diagnostic activity. Conclusions: The substantially lower mortality in units with the highest exposure to radical local treatment suggests that radical treatment decreases mortality even in men with very high-risk PCa for whom such treatment has been considered ineffective. Patient summary: Menwith very high-risk prostate cancer diagnosed and treated in units with the highest exposure to surgery or radiotherapy had a substantially lower mortality.

  • Granados, Carlos
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Jefferson Lab, 12000 Jefferson Ave, Newport News, VA 23606 USA..
    Leupold, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Perotti, Elisabetta
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    The electromagnetic Sigma-to-Lambda hyperon transition form factors at low energies2017In: European Physical Journal A, ISSN 1434-6001, E-ISSN 1434-601X, Vol. 53, no 6, 117Article in journal (Refereed)
    Abstract [en]

    Using dispersion theory the low-energy electromagnetic form factors for the transition of a Sigma to a Lambda hyperon are related to the pion vector form factor. The additionally required input, i.e. the two-pion-Sigma-Lambda amplitudes are determined from relativistic next-to-leading-order (NLO) baryon chiral perturbation theory including the baryons from the octet and optionally from the decuplet. Pion rescattering is again taken into account by dispersion theory. It turns out that the inclusion of decuplet baryons is not an option but a necessity to obtain reasonable results. The electric transition form factor remains very small in the whole low-energy region. The magnetic transition form factor depends strongly on one not very well determined low-energy constant of the NLO Lagrangian. One obtains reasonable predictive power if this low-energy constant is determined from a measurement of the magnetic transition radius. Such a measurement can be performed at the future Facility for Antiproton and Ion Research (FAIR).

  • Dutoit, Ludovic
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Burri, Reto
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Nater, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Mugal, Carina F.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Hans, Ellegren
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Genomic distribution and estimation of nucleotide diversity in natural populations: perspectives from the collared flycatcher (Ficedula albicollis) genome2017In: Molecular Ecology Resources, ISSN 1755-098X, E-ISSN 1755-0998, Vol. 17, no 4, 586-597 p.Article in journal (Refereed)
    Abstract [en]

    Properly estimating genetic diversity in populations of nonmodel species requires a basic understanding of how diversity is distributed across the genome and among individuals. To this end, we analysed whole-genome resequencing data from 20 collared flycatchers (genome size approximate to 1.1 Gb; 10.13 million single nucleotide polymorphisms detected). Genomewide nucleotide diversity was almost identical among individuals (mean = 0.00394, range = 0.00384-0.00401), but diversity levels varied extensively across the genome (95% confidence interval for 200-kb windows = 0.0013-0.0053). Diversity was related to selective constraint such that in comparison with intergenic DNA, diversity at fourfold degenerate sites was reduced to 85%, 3' UTRs to 82%, 5' UTRs to 70% and nondegenerate sites to 12%. There was a strong positive correlation between diversity and chromosome size, probably driven by a higher density of targets for selection on smaller chromosomes increasing the diversity-reducing effect of linked selection. Simulations exploring the ability of sequence data from a small number of genetic markers to capture the observed diversity clearly demonstrated that diversity estimation from finite sampling of such data is bound to be associated with large confidence intervals. Nevertheless, we show that precision in diversity estimation in large out-bred population benefits from increasing the number of loci rather than the number of individuals. Simulations mimicking RAD sequencing showed that this approach gives accurate estimates of genomewide diversity. Based on the patterns of observed diversity and the performed simulations, we provide broad recommendations for how genetic diversity should be estimated in natural populations.

  • Public defence: 2017-09-16 13:15 Fåhraeussalen, Rudbecklaboratoriet Hus 5, Uppsala
    Maharjan, Rajani
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    New Insights in Adrenal Tumourigenesis.2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. Although the overall survival of the patients with ACC is very poor, the outcome can be heterogeneous and vary significantly between the patients. This thesis comprises studies showing genetic and genomic events occurring in CPAs and ACCs, their functional impact and clinical correlations.

    The Wnt/β-catenin and cAMP/PKA signalling pathways are crucial in adrenal homeostasis and frequent mutations in members of these pathways (CTNNB1, GNAS, and PRKACA) are found in CPAs. Mutational analysis revealed that ~60% of the CPAs harboured mutations in either of these genes. Transcriptome signature exhibited increased expression of genes involved in steroidogenesis in PRKACA/GNAS mutated (Cluster1) tumours in comparison to CTNNB1 mutated /wildtype (Cluster2) tumours. In addition we have also observed that gain of chromosome arm 9q was the most frequent arm level copy number variation (CNV) occurring in CPAs and were exclusively present in Cluster2 tumours. We also discovered novel PRKACA mutations occurring in ACCs, causing activation of cAMP/signalling pathway.   

    Comprehensive analysis of Wnt/β-catenin signalling pathway in ACCs revealed novel interstitial deletions occurring in CTNNB1 leading to deletion of the N-terminus of β-catenin. This is a novel and yet another frequent event leading to activated Wnt/β-catenin signalling and downstream targets in ACCs. Both, mutations occurring in CTNNB1 and nuclear expression of its protein were associated with poor overall survival. Through multiregional sampling approach we discovered intra-tumour heterogeneity in ACC tumours. Although all the multiregions within a tumour showed presence of shared basal CNVs, they encompassed private CNVs, different ploidy levels and private mutations in known driver genes. We found intra-tumour heterogeneity in CTNNB1, PRKACA, TERT promoter and TP53 mutations as well as ZNRF3 and CDKN2A/2B homozygous deletions.

    List of papers
    1. Integrated Molecular Characterization of Benign Cortisol Producing Adenomas Defines Two Distinct Clusters.
    Open this publication in new window or tab >>Integrated Molecular Characterization of Benign Cortisol Producing Adenomas Defines Two Distinct Clusters.
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    (English)Manuscript (preprint) (Other academic)
    Keyword
    cortisol producing adenoma, mutation, expression, PRKACA, CTNNB1, GNAS
    National Category
    Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Cell and Molecular Biology
    Research subject
    Endocrinology and Diabetology
    Identifiers
    urn:nbn:se:uu:diva-325973 (URN)
    Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-05
    2. Identification and Characterization of Novel PRKACA Mutations in Adrenocortical Tumors.
    Open this publication in new window or tab >>Identification and Characterization of Novel PRKACA Mutations in Adrenocortical Tumors.
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    (English)Manuscript (preprint) (Other academic)
    Keyword
    PRKACA, Mutations, Adrenal
    National Category
    Cell and Molecular Biology Cancer and Oncology
    Research subject
    Molecular Genetics; Endocrinology and Diabetology
    Identifiers
    urn:nbn:se:uu:diva-325978 (URN)
    Funder
    Swedish Cancer Society
    Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-05
    3. Intratumoural Heterogeneity of TERT Promoter Mutations in Adrenocortical Carcinoma
    Open this publication in new window or tab >>Intratumoural Heterogeneity of TERT Promoter Mutations in Adrenocortical Carcinoma
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    (English)Manuscript (preprint) (Other (popular science, discussion, etc.))
    Keyword
    TERT, Adrenocortical Carcinoma, Mutation, Heterogeneity.
    National Category
    Cell and Molecular Biology Cancer and Oncology
    Research subject
    Molecular Genetics; Endocrinology and Diabetology
    Identifiers
    urn:nbn:se:uu:diva-325979 (URN)
    Funder
    Swedish Cancer Society
    Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-05
    4. Comprehensive analysis of CTNNB1 in adrenocortical carcinomas: Identification of novel mutations and correlation to survival.
    Open this publication in new window or tab >>Comprehensive analysis of CTNNB1 in adrenocortical carcinomas: Identification of novel mutations and correlation to survival.
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    (English)Manuscript (preprint) (Other academic)
    Keyword
    adrenocortical carcinomas, CTNNB1, mutation, β-Catenin, survival
    National Category
    Cell and Molecular Biology Cancer and Oncology
    Research subject
    Molecular Genetics; Endocrinology and Diabetology
    Identifiers
    urn:nbn:se:uu:diva-325980 (URN)
    Funder
    Swedish Cancer Society
    Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-05
    5. Multidimensional Genetic Analysis of Adrenocortical Cancers
    Open this publication in new window or tab >>Multidimensional Genetic Analysis of Adrenocortical Cancers
    (English)Manuscript (preprint) (Other academic)
    Keyword
    adrenocortical carcinoma, mutation, chromosomal aberration, CNV
    National Category
    Cancer and Oncology Endocrinology and Diabetes Cell and Molecular Biology
    Research subject
    Endocrinology and Diabetology; Molecular Genetics
    Identifiers
    urn:nbn:se:uu:diva-325981 (URN)
    Funder
    Swedish Cancer Society
    Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-05
  • Anners, Carl
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    FORECASTING ENERGY USAGE IN THE INDUSTRIAL SECTOR IN SWEDEN USING SARIMA AND DYNAMIC REGRESSION2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Accurate prediction of future events is of great interest in various contexts. This thesis focuses on forecasting and predicting energy usage in the industrial sector, which provides valuable information for government agencies to plan and allocate the available budget. More specifically, the purpose is to evaluate if using explanatory variables in a dynamic regression with seasonal autoregressive integrated moving average (SARIMA) errors improves the forecasting accuracy of quarterly energy usage in the industrial sector in Sweden compared to a standard SARIMA model. The SARIMA model used for comparison is SARIMA(1,0,0)(0,1,1), while the dynamic regression model used has the explanatory variable value added of the industrial sector and SARIMA(1,0,0)(0,1,1) errors. The forecast performance of the two models is compared for both quarterly and yearly forecast horizons using root mean squared error (RMSE) and mean absolute error (MAE). The results show that the RMSE and MAE of the dynamic regression model are lower for both forecast horizons compared to the SARIMA model. Also, a significance test (OOS-t) and an encompassing test (ENC-NEW) are employed, which show that the difference in forecasting accuracy is statistically significant and that the SARIMA forecast doesn’t encompass the forecast of the dynamic regression model.

  • Altenburger, Andreas
    et al.
    Martinez, Pedro
    Budd, Graham E.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Holmer, Lars E.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Gene Expression Patterns in Brachiopod Larvae Refute the "€œBrachiopod-Fold"€ Hypothesis2017In: Frontiers in Cell and Developmental Biology, Vol. 5, 1-3 p., 74Article in journal (Refereed)
  • Schouten, Fleur
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history.
    Pederasti i antikens Athen: En studie av normer i Aischines tal mot Timarchos2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In this essay, I researched the Athenian attitudes towards same sex relationships between men during the classical period, a subject that was made popular in the 1970’s by James Dover. After a short introduction on how homosexuality was perceived and a thorough walkthrough of Aeschines speech Against Timarchus, I reached a better understanding of two main questions, the first being what the role of pederasty was, how boys were protected by the law and if the law was only meant to protect boys or also adult men. The second question being whether Timarchus was guilty of prostitution or the jury judged him wrongfully. Through using the method close reading of the speech, in which Aeschines accuses Timarchus of theft and prostitution, which the jury voted Timarchus to be guilty of, I try to answer those two questions. In the process, I also discuss Aeschines relationship with Demosthenes, the person who spoke in Timarchus favour. The conclusion I come to for the first question is that there were certain laws in place for pederasty, some of which must have protected the boys, but as other authors before me have pointed out also must have been in place to protect adults from being tempted to, what they considered, sin.

    For the second question, I conclude that Aeschines is lacking evidence of Timarchus' crimes of prostitution. Before Timarchus was put on trial he was about to prosecute Aeschines, which is a motive for Aeschines to get him banned from public speaking, a matter easily achieved by getting Timarchus judged guilty of crimes, I believe, were made up. 

  • Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Probability Theory.
    Hodge Decomposition for Manifolds with Boundary and Vector Calculus2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Reu, Pedro
    et al.
    Khosravi, Azadeh
    Bernard, Samuel
    Mold, Jeff E.
    Salehpour, Mehran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Alkass, Kanar
    Perl, Shira
    Tisdale, John
    Possnert, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Druid, Henrik
    Frisen, Jonas
    The Lifespan and Turnover of Microglia in the Human Brain2017In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 20, no 4, 779-784 p.Article in journal (Refereed)
    Abstract [en]

    The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life.

  • Public defence: 2017-09-13 09:00 B7 111:a, BMC, Uppsala
    Zhao, Jin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Sequence based identification of genetic variation associated with intellectual disability2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Intellectual disability (ID) is a common neurodevelopmental condition, often caused by genetic defects. De novo variation (DNV) is an important cause of ID, especially in severe or syndromic forms of the disorder. Next generation sequencing has been a successful application for finding pathogenic variation in ID patients. The main focus of this thesis is to use whole exome sequencing (WES) and whole genome sequencing (WGS) to identify pathogenic variants in undiagnosed ID patients. In Paper I, WES was used in family trios to identify pathogenic DNVs in patients diagnosed with ID in combination with epilepsy. This work led to the identification of several DNVs in both new and known disease genes, including the first report of variation in the HECW2 gene in association with neurodevelopmental disorder and epilepsy. Paper II is the first independent validation of PIGG as a disease-causing gene in patients with developmental disorder. We used WES to identify the homozygous variation in PIGG, and transcriptome analysis as well as flow-cytometry studies were used to validate the pathogenicity of the PIGG variation. We discovered that PIGG variation give different effects in different cell types, contributing new insights into the disease mechanism. Paper III is also an application of WES in trio families with patients diagnosed with ID in order to identify causal variants, a strategy similar to that of Paper I. Several pathogenic variants were identified in this study; in particular, the gene NAA15 is highlighted as a new disease gene, and was recently confirmed in independent studies. This study also adds evidence to support that variation in the PUF60 gene is causing the symptoms in patients with Verheij syndrome. In Paper IV, WGS was used to analyze families with consanguineous marriages. All families in this study had been previously analyzed with WES without finding a disease cause. A number of new disease-causing variants were identified in the study, including a first validation of FRMD4A as a disease-associated gene. This study also shows that WGS performs better than WES in finding variants, even for variants in coding parts of the genome.

    List of papers
    1. Mutations in HECW2 are associated with intellectual disability and epilepsy
    Open this publication in new window or tab >>Mutations in HECW2 are associated with intellectual disability and epilepsy
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    2016 (English)In: Journal of Medical Genetics, ISSN 0022-2593, E-ISSN 1468-6244, Vol. 53, no 10, 697-704 p.Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND: De novo mutations are a frequent cause of disorders related to brain development. We report the results of screening patients diagnosed with both epilepsy and intellectual disability (ID) using exome sequencing to identify known and new causative de novo mutations relevant to these conditions.

    METHODS: Exome sequencing was performed on 39 patient-parent trios to identify de novo mutations. Clinical significance of de novo mutations in genes was determined using the American College of Medical Genetics and Genomics standard guidelines for interpretation of coding variants. Variants in genes of unknown clinical significance were further analysed in the context of previous trio sequencing efforts in neurodevelopmental disorders.

    RESULTS: In 39 patient-parent trios we identified 29 de novo mutations in coding sequence. Analysis of de novo and inherited variants yielded a molecular diagnosis in 11 families (28.2%). In combination with previously published exome sequencing results in neurodevelopmental disorders, our analysis implicates HECW2 as a novel candidate gene in ID and epilepsy.

    CONCLUSIONS: Our results support the use of exome sequencing as a diagnostic approach for ID and epilepsy, and confirm previous results regarding the importance of de novo mutations in this patient group. The results also highlight the utility of network analysis and comparison to previous large-scale studies as strategies to prioritise candidate genes for further studies. This study adds knowledge to the increasingly growing list of causative and candidate genes in ID and epilepsy and highlights HECW2 as a new candidate gene for neurodevelopmental disorders.

    Keyword
    Intellectual disability; Epilepsy; Exome sequencing; HECW2; ERC2
    National Category
    Medical Genetics
    Identifiers
    urn:nbn:se:uu:diva-301393 (URN)10.1136/jmedgenet-2016-103814 (DOI)000385958500008 ()27334371 (PubMedID)
    Funder
    EU, European Research Council, 282330Swedish Society for Medical Research (SSMF)
    Available from: 2016-08-31 Created: 2016-08-22 Last updated: 2017-07-04Bibliographically approved
    2. Reduced cell surface levels of GPI-linked markers in a new case with PIGG loss of function
    Open this publication in new window or tab >>Reduced cell surface levels of GPI-linked markers in a new case with PIGG loss of function
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    (English)In: Human Mutation, ISSN 1059-7794, E-ISSN 1098-1004Article in journal (Refereed) Epub ahead of print
    Keyword
    PIGG, GPI deficiency, Intellectual disability, Exome sequencing
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-326282 (URN)
    Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-07-04
    3. Exome sequencing reveals NAA15 and PUF60 as candidate genes associated with intellectual disability
    Open this publication in new window or tab >>Exome sequencing reveals NAA15 and PUF60 as candidate genes associated with intellectual disability
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-326280 (URN)
    Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-07-04
    4. Whole genome sequencing of consanguineous families reveals novel pathogenic variants in intellectual disability
    Open this publication in new window or tab >>Whole genome sequencing of consanguineous families reveals novel pathogenic variants in intellectual disability
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-326281 (URN)
    Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-07-04
  • Public defence: 2017-09-04 11:38 E10:2309, Uppsala
    Steinhauf, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Importance of the Clr2 protein in heterochromatin formation in the fission yeast Schizosaccharomyces pombe2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Epigenetics is an area of biology that studies heritable changes in gene ex- pression without any change in the DNA sequence. The most studied epige- netic mechanisms are DNA methylation, RNA interference and histone mod- ifications. There are over 130 different modifications that can be attached to histones, and the most commonly studied are methylation, acetylation, phos- phorylation, sumoylation and ubiquitination. The modifications, spread out through the genome, form the histone code, which recruits transcription fac- tors and modifies the accessibility of the DNA, which results in either active or silenced transcription. The silenced form of chromatin is known as heter- ochromatin and is usually found in regions of the chromosome that need to be highly regulated. To study epigenetics, the model organism Schizosac- charomyces pombe is used widely used. S. pombe is a single cell, rod shaped, fission yeast. The simplicity of S. pombe and its similarities to high- er eukaryotes makes it a good model organism for studying epigenetics. We find that, when mutating evolutionary conserved amino acids in the Clr2 protein, which is involved in heterochromatin formation in S. pombe, there is a change in silencing in different heterochromatic regions. When constructs of Clr2 with the BAH domain deleted are overexpressed, there is an increase in silencing in the central core centromere of chromosome II of S. pombe. 

    List of papers
    1. Silencing Motifs in the Clr2 Protein from Fission Yeast, Schizosaccharomyces pombe
    Open this publication in new window or tab >>Silencing Motifs in the Clr2 Protein from Fission Yeast, Schizosaccharomyces pombe
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    2014 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 9, no 1, e86948- p.Article in journal (Refereed) Published
    Abstract [en]

    The fission yeast, Schizosaccharomyces pombe, is a well-established model for heterochromatin formation, but the exact sequence of events for initiation remains to be elucidated. The essential factors involved include RNA transcribed from repeated sequences together with the methyltransferase Clr4. In addition, histone deacetylases, like Clr3, found in the SHREC complex are also necessary for transcriptional silencing. Clr2 is another crucial factor required for heterochromatin formation found in the SHREC complex. The function of Clr2 has been difficult to establish due to the lack of conserved domains or homology to proteins of known molecular function. Using a bioinformatics approach, three conserved motifs in Clr2 were identified, which contained amino acids important for transcriptional repression. Analysis of clr2 mutant strains revealed a major role for Clr2 in mating-type and rDNA silencing, and weaker effects on centromeric silencing. The effect on mating-type silencing showed variegation in several of the strains with mutated versions of Clr2 indicating an establishment or maintenance defect. Moreover, the critical amino acids in Clr2 were also necessary for transcriptional repression in a minimal system, by the tethering of Clr4 upstream of a reporter gene, inserted into the euchromatic part of the genome. Finally, in silico modeling suggested that the mutations in Clr2 cause disruption of secondary structures in the Clr2 protein. Identification of these critical amino acids in the protein provides a useful tool to explore the molecular mechanism behind the role of Clr2 in heterochromatin formation.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-219965 (URN)10.1371/journal.pone.0086948 (DOI)000330507300119 ()
    Available from: 2014-03-12 Created: 2014-03-09 Last updated: 2017-08-21Bibliographically approved
  • Blomstrand, Patrik
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Jemander, Rasmus
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    Systemteknisk studie av pumpstyrning på Henriksdals nya reningsverk2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The population of Stockholm is increasing and with it the amount of wastewater that needs treatment. To cope with the increase, Henriksdal wastewater treatment plant (WWTP) in Stockholm, Sweden, is currently being expanded into the worlds largest WWTP using membrane bioreactor (MBR) technology. The plant will be controlled to a greater extent by pumps and good control is therefore vital to maintain operational stability and an energy efficient process. To analyse the intricate system of pumps and equalisation in tunnels a dynamic model is required.One reason for expanding Henriksdal WWTP is the decommissioning of Bromma WWTP. Wastewater from Bromma will be diverted to Henriksdal through a large tunnel which can be used for flow equalization. To examine whether flow equalization in the tunnel can even out diurnal variations and extreme rain events, water flow in the tunnel and throughout the WWTP was modelled. Models of the tunnel, pumps and basins were made in the programming language C and then merged with different controllers in Matlab/Simulink. To simulate different scenarios for the year 2040, data for the rainy year of 2012 was increased to match the expected population for 2040.Based on simulations for a scenario with dry weather the possibility for flow equalization could be shown. It required a thought-out control strategy for the control of Bromma pumping station based on flow measurements from several other inflows to the WWTP. The control strategy also proved adequate in handling downpours by increasing the amount of waste water subjected to biological treatment. When simulating snow melt or heavy rain, damming in the Bromma tunnel could help to prevent overflow if no strict boundaries were used for the water level in the tunnel. With a maximum allowed water level of 10 m it was, however, possible to dam the first flush containing high concentrations of pollutants and nutrients.Flow equalization makes it easier to maintain even levels in the basins for the return activated sludge (RAS), which in turn makes it easier to maintain high levels in said basins. Higher levels in the RAS-basins leads to reduced energy consumption. In the event of further development of the model, it is possible to add calculations of energy usage for the pumps, which would facilitate further optimization of controllers and their parameters.

  • Norström, Fredrik
    et al.
    Umeå Univ, Dept Publ Hlth & Clin Med Epidemiol & Global Hlth, SE-90187 Umeå, Sweden..
    Janlert, Urban
    Umeå Univ, Dept Publ Hlth & Clin Med Epidemiol & Global Hlth, SE-90187 Umeå, Sweden..
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Is unemployment in young adulthood related to self-rated health later in life?: Results from the Northern Swedish cohort2017In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 17, 529Article in journal (Refereed)
    Abstract [en]

    Background: Many studies have reported that unemployment has a negative effect on health. However, little is known about the long-term effect for those who become unemployed when they are young adults. Our aim was to examine how unemployment is related to long-term self-rated health among 30 year olds, with an emphasis on how health differs in relation to education level, marital status, previous health, occupation, and gender. Methods: In the Northern Swedish Cohort, 1083 teenagers (similar to 16 years old) were originally invited in 1981. Of these, 1001 participated in the follow-up surveys in 1995 and 2007. In our study, we included participants with either self-reported unemployment or activity in the labor force during the previous three years in the 1995 follow-up so long as they had no self-reported unemployment between the follow-up surveys. Labor market status was studied in relation to self-reported health in the 2007 follow-up. Information from the 1995 follow-up for education level, marital status, self-reported health, and occupation were part of the statistical analyses. Analyses were stratified for these variables and for gender. Analyses were performed with logistic regression, G-computation, and a method based on propensity scores. Results: Poor self-rated health in 2007 was reported among 43 of the 98 (44%) unemployed and 159 (30%) of the 522 employed subjects. Unemployment had a long-term negative effect on health (odds ratio with logistic regression 1.74 and absolute difference estimates of 0.11 (G-computation) and 0.10 (propensity score method)). At the group level, the most pronounced effects on health were seen in those with upper secondary school as their highest education level, those who were single, low-level white-collar workers, and women. Conclusions: Even among those becoming unemployed during young adulthood, unemployment is related to a negative long-term health effect. However, the effect varies among different groups of individuals. Increased emphasis on understanding the groups for whom unemployment is most strongly related to ill health is important for future research so that efforts can be put towards those with the biggest need. Still, our results can be used as the basis for deciding which groups should be prioritized for labor-market interventions.

  • Melcherson, Tim
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Gustavsson, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Gideonsson, Albin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Spybot - Webbstyrd robot med värmesensor2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I detta projekt byggdes en fjärrstyrd robot som styrs över Wi-Fi, ochstreamar video till användaren av vad den ser. Som komplement körsäven en temperatursensor för att utöka robotens möjlighet att kännaav sin omgivning. Huvudkomponenten är en Raspberry PI 3 modell B, därall kod för styrning och hemsidekontrollerna körs. Resultatet är enrobot som kan styras utanför synhåll och kan sända tillbaka en stabilkameraström så länge den är kopplad till ett stabilt nätverk.Dessvärre sjunker resultatet i takt med nätverkskvalitén. Vid ettsvagare nätverk blir det långa laddningstider för kameraströmmenvilket leder till att roboten blir mindre responsiv. Det tillsammansmed den förlorade kameraströmmen resulterar i att roboten ärobrukbar. Vid tillräckligt svaga nätverk, eller vid nätverksproblemkommer roboten repetera sin sista order tills dess att kontakt äråterupprättad.

  • Riede, Felix
    et al.
    Aarhus Univ.
    Andersen, Per
    Aarhus Univ.
    Price, Neil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Does environmental archaeology need an ethical promise?2017In: World archaeology, ISSN 0043-8243, E-ISSN 1470-1375, Vol. 48, no 4, 466-481 p.Article in journal (Refereed)
    Abstract [en]

    Environmental catastrophes represent profound challenges faced by societies today. Numerous scholars in the climate sciences and the humanities have argued for a greater ethical engagement with these pressing issues. At the same time, several disciplines concerned with hazards are moving towards formalized ethical codes or promises that not only guide the dissemination of data but oblige scientists to relate to fundamentally political issues. This article couples a survey of the recent environmental ethics literature with two case studies of how past natural hazards have affected vulnerable societies in Europe's prehistory. We ask whether cases of past calamities and their societal effects should play a greater role in public debates and whether archaeologists working with past environmental hazards should be more outspoken in their ethical considerations. We offer no firm answers, but suggest that archaeologists engage with debates in human-environment relations at this interface between politics, public affairs and science.

  • Fridlund, Julia
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Analysis of Multicomponent Data to Study Esker Structures, Turku-Finland2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Eskers are long winding ridges that originate from gravel that has travelled in meltwater streams in glaciers. At the study site, Virttaankangas plane in southwest Finland, there are esker structures covered by sediments. One reason why it is important to study eskers is because they are used for purifying drinking water. The data used in the study were collected during a seismic survey in July 2014. During the survey a controlled source created seismic waves that travelled down through the earth and then reflected back up again. By detecting the travel time of the waves and estimating the velocity of the geologic layers, the depth to the reflecting structures could be calculated. There are two types of waves that travel through the body of the earth, pressure waves (P-waves) and shear waves (S-waves). In a previous study (Maries et al., 2017) P-wave data from the same survey have been analyzed, so this work focuses on S-wave data but also compares the result from the two. Some structures related to eskers were identifiable, such as fractures in the bedrock from the pressure of the main esker core. By comparing S- and P-wave results it was possible to see hints of the arched esker cores and esker fan lobes. Overall the result confirmed the model that was achieved of the profile in the previous study. The location of the bedrock both matched with the previous study, and added information about its orientation. An additional goal was to demonstrate the insensitivity of S-waves to water content by showing that if there was a water table reflection in the P-wave data, this reflection was missing in the S-wave data. The results showed water table reflections in the P-wave data, but there were no distinguishable water table reflections with appropriate velocity for S-waves in the S-wave data.

  • Schümann, Luisa
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Dzúriková, Andrea
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Diffusion of Social Innovations: A case study on Suspended Coffees Germany2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Despite the relevance of social innovations in the sustainable development, little is known about the drivers that help to spread them. Innovative ideas are developed to meet the needs of local communities and therefore often remain at a regional level; nevertheless, diffusion and scaling are necessary in order to lead to a societal change. This thesis analyses the case of Suspended Coffees, a successful diffusion of a social innovation in Germany. The research focuses on businesses adopting the social innovation to examine the drivers of diffusion. 24 interviews with business owners and two in-depth expert interviews with the German coordination body were conducted. The results illustrate (1) the existence of social needs, (2) the strong personal motivations of adopters, and (3) the compatibility of the innovation with adopting businesses and the social ecosystem, as main drivers of the diffusion. The study thereby expands the limited research in the field of the diffusion of social innovations.

  • Zhao, Rui
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Dia, Uzezi
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Digital Service through Sharing Economy to Sustainability: A car sharing case in Suzhou, China2017Independent thesis Advanced level (degree of Master (One Year)), 60 credits / 90 HE creditsStudent thesis
    Abstract [en]

    The rapid increase in car ownership has caused rigorous issues for people living in the major cities in China, which is observe from traffic pressure, the inconvenience of city travelling, and air pollution. While the fast development of digital service platforms based on the Internet provides an alternative approach to touch the problems, leading a researchable phenomenon, online car-sharing service in China.

    This paper strives to explore the impact of car sharing on millennial sustainability attitudes by using the daily service on apps to ‘drive less, share more’. The paper is conducted using mixed research methods in Suzhou, China. Principally, the researchers interviewed ten car- sharing consumers during shared ride. To ensure the creditability and reliability, the paper collected 326 online survey responses from local car-sharing platforms as comparable data.

    The results show that most millennials agree car-sharing service makes their traffic modes more convenient, and taking shared ride more compared to self-driving has a significant influence on social and environmental issues in cities. Also, some respondents present willingness or already take actions on giving up car ownerships. However, the result also emphasises the fundamental reasons for millennials to participate in car-sharing service, which is personalised service and reasonable price. The paper closes with three outcomes, sharing economy as ‘Development’, digital service as ‘Innovation’, and sustainability as ‘The future’. They not only enrich the current literature research between Millennials and sharing economy, but also promote further strategies for car-sharing companies with empirical data. 

  • Buratovic, Emma
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Cocalic, Dervis
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Eliasson, Kasper
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Danestig, Matilda
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Everlid, Linus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Controversial Materials: Ethical issues in the production of mineral based raw materials2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This report has investigated the ethical issues associated with mining or processing of materials that make them considered as controversial. For each material, the main areas of use and the top producing countries are analysed, followed by social and/or environmental issues as well as potential problems in the future. In total, 13 materials are discussed, of which most are minerals. The overall issues, that are recurring throughout the report and are important to be aware of are: child labor, low safety standards, mining activity resulting in deforestation or harming biodiversity, mining processes that affect communities (e.g. because of large water consumption) and the risks associated with widespread illegal mining. The report also provides research about organisations and initiatives that aim to affect the problems, and gives a brief view over tools that can be used to increase awareness of these issues.

  • Lagerstedt, David
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    White, Stuart
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Do Acquirers Benefit from M&A’s? -: An Event Study on 517 Swedish M&A’s: 1998-20162017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis builds upon literature that for many decades have examined the possible wealth creation of M&A’s. We investigate the acquiring firms share value response to M&A’s performed by public acquirers active on the Swedish market in 1998-2016. Our research builds upon previously conducted studies depicting both positive- and negative returns. Furthermore, our study considers how M&A’s are affected by merger waves and their creation of hot and cold markets. Our sample consists of 517 acquisitions including both smaller and larger transactions. Through an event-study, we investigate how the share value reacts during an 11 day event window surrounding the announcement of an M&A. Our findings show predominantly positive abnormal returns disputing much of the previous M&A research. Additionally, because abnormal returns are present throughout the event window, our results indicate that the Swedish market does not operate at a strong level of efficiency. Our main contribution is providing a coherent view of M&A’s conducted in Sweden during nearly two decades. As well as, providing evidence that M&A’s create value for the acquirer.

  • Ekstrand, Oscar
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Desai, Sagar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Egenskapsdriven utveckling: En fallstudie på Scanias forskning & utvecklingsavdelning2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Purpose: The study has been performed in order to investigate the possibilities of visualizing customer value generated by Scania’s project portfolio. By designing a method able to visualize the customer value in the project portfolio, the aim is to make it easier to prioritize projects and to mediate the company's strategic goals to an operational level.

    Research questions: 1. How is customer value integrated into Scanias project portfolio management? 2. What challenges does property driven development cause at Scania? 3. How can a method be designed in order to visualize the customer value within Scanias project portfolio?

    Methodology: This master thesis has been performed as an abductive case study at Scania’s research and development division in Södertälje. A qualitative approach has been used where approximately 30 interviews has been the main source for primary data. In addition, secondary data extracted from internal documents has been used in order to understand the company specific context. Literature that addresses customer value and project portfolio management has guided the study.

    Findings: A method named “Earned Customer Value-GANTT” has been designed, which is able to estimate the future customer value within the project portfolio. By using this method, it is possible to manage the project portfolio with regard to what customer value the company want to deliver in the future. No other similar methods have been identified making it a new way to manage the portfolio. However, the method comes with a few challenges that are both company specific as well as general.

  • Kwiatkowski, Larissa
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Paths to Meaningful Youth Involvement at the International Climate Change Negotiations: Lessons from COP22 in Marrakesh2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the last decade, anthropogenic climate change has caused strong impacts on natural and human systems worldwide. It is of particular importance to include youths in the international decision-making process centred on climate change as they represent the closest living relatives to future generations. Therefore they need to have a say in the decisions affecting their future. Different schools of thought defined characteristics for ideal communication in these political decision-making arenas. The most contradicting theories are on one hand deliberative democrats who favour dialogic and consensus-based proceedings and on the other hand proponents of agonistic pluralism who prefer the conflictual elements of force and disruption in communication processes. The aim of this study is to explore synergies and intersections between both in theory contradicting paths. The study follows a case study design of the international climate change negotiations COP22 in Marrakech 2016. The data collection process involved empirical observations and semi-structured interviews with 30 international youth participants as to their experiences of participating in proceedings, petitioning politicians, and protesting outside venues. The results of this study show that young people concurrently navigate between formal deliberative proceedings and informal agonistic approaches, taking advantage of their underacknowledged positive cumulative and complementing effects. The interplay between both paths stimulates meaningful involvement for youths at the conference and within the climate change social movement. Youths navigating simultaneously between both paths are shown to have both insider knowledge about the vulnerabilities of the system and outsider knowledge providing enough distance to criticise the proceedings. Thus, these youths have the best merits to meaningfully involve in the decision making and successfully introduce change. The process of enculturation to the norms and procedural rules of the conference contributes to the level of meaningful youth involvement and determines the participation path chosen. Moreover, the results outline that the influence of each path in the decision-making process and the definition of meaningful involvement varies with the arena in which it is executed. Whereas meaningful involvement for deliberative inclined youths can be best described through a shared power youth-adult participation, youths following the agonistic path seek meaningful involvement through emotion work and empowerment expressed in direct actions and protest.

  • Anthon, Jonsson
    et al.
    Vincent, Ricknell
    Project in Electrical Engineering: Electric Skateboard2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Clarqvist, Björn
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Andersson, Lukas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Zwart, Jaap-jan
    Benefits of using offline & online methods in the internationalization process: A study of e-commerce companies in Sweden2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Technical advances have made it possible for small enterprises to go international already at inception since the internet has made the internationalization process cost-effective. With the existence of the offline and online arena, the companies have to consider how they allocate their resources between these fields; not allocating resources to offline methods can save money, but could reduce adaptation to the new market which can lead to reduced firm performance. However, overspending on offline methods can be costly and could jeopardize the financial stability of the company. Although this is noted by previous research, little is still known about how companies balance the resources between online and offline presence. Especially when it comes to e-commerce companies and how the benefits of online and offline presence are balanced by this type of firms in their expansion into foreign markets. This is also what is meant to be explored in this paper.

    The data has been collected through semi-structured interviews with seven Swedish e-commerce companies that have internationalized their operations in an active way. The results show that online and offline benefits can be divided into four categories, namely local knowledge, local connection, promotion and services. These categories could in turn bring benefits to the company that are either substitutable, non-substitutable or complementary. The findings indicate that firms could balance their resources in online and offline presence in order to gain benefits that cannot be found in the counterparts of each presence. This could be of interest for entrepreneurs and managers that plan to engage in internationalization within e-commerce.

  • Åhlin, Ida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Boplatser från järnålderns Gamla Uppsala - en makrofossilanalys2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Ruan, Changqing
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Strømme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Mihranyan, Albert
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Lindh, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Favored Surface-limited Oxidation of Cellulose with Oxone® in Water2017In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, 40600-40607 p.Article in journal (Refereed)
    Abstract [en]

    A novel method for favored primary alcohol oxidation of cellulose was developed. Cellulose pulp andCladophora nanocellulose were oxidized in a one-pot procedure by Oxone® (2KHSO5$KHSO4$K2SO4)and efficient reaction conditions were identified. The effects of the reaction on the morphology,viscosity and chemical structure of the products obtained were studied. The primary alcohol groupswere oxidized to carboxyl groups and the content of carboxyl groups was determined byconductometric titration. SEM, capillary-type viscometry and XRD were applied to characterize theproducts and to investigate the influence of oxidation. For the first time, low-cost and stable Oxone®was used as a single oxidant to oxidize cellulose into carboxyl cellulose. The oxidation is an inexpensiveand convenient process to produce carboxylic groups on the surface of the cellulose fibers and to makethe cellulose fibers charged. Particularly, this method can avoid the use of halogens and potentially toxicradicals and constitute a green route to access carboxylated cellulose. Further, sodium bromide could beused as a co-oxidant to the Oxone® and increase the carboxylic acid content by 10–20%. The Oxone®oxidation is a promising method for oxidation of cellulose and might facilitate the production of CNC.

  • Theo, Berggren
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Norm Conflicts in Public International Law: The Relationship Between Obligations Under the ECHR and Under the UN Charter2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Public defence: 2017-09-13 09:00 A1:111 BMC, Uppsala
    Bauer, Paul
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Computational modelling of enzyme selectivity2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Enantioselective reactions are one of the ways to produce pure chiral compounds. Understanding the basis of this selectivity makes it possible to guide enzyme design towards more efficient catalysts. One approach to study enzymes involved in chiral chemistry is through the use of computational models that are able to simulate the chemical reaction taking place. The potato epoxide hydrolase is one enzyme that is known to be both highly enantioselective, while still being robust upon mutation of residues to change substrate scope. The enzyme was used to investigate the epoxide hydrolysis mechanism for a number of different substrates, using the EVB approach to the reaction both in solution and in several enzyme variants. In addition to this, work has been performed on new ways of performing simulations of divalent transition metals, as well as development of new simulation software.

    List of papers
    1. Force Field Independent Metal Parameters Using a Nonbonded Dummy Model
    Open this publication in new window or tab >>Force Field Independent Metal Parameters Using a Nonbonded Dummy Model
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    2014 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 118, no 16, 4351-4362 p.Article in journal (Refereed) Published
    Abstract [en]

    The cationic dummy atom approach provides a powerful nonbonded description for a range of alkaline-earth and transition-metal centers, capturing both structural and electrostatic effects. In this work we refine existing literature parameters for octahedrally coordinated Mn2+, Zn2+, Mg2+, and Ca2+, as well as providing new parameters for Ni2+, Co2+, and Fe2+. In all the cases, we are able to reproduce both M2+-O distances and experimental solvation free energies, which has not been achieved to date for transition metals using any other model. The parameters have also been tested using two different water models and show consistent performance. Therefore, our parameters are easily transferable to any force field that describes nonbonded interactions using Coulomb and Lennard-Jones potentials. Finally, we demonstrate the stability of our parameters in both the human and Escherichia coli variants of the enzyme glyoxalase 1 as showcase systems, as both enzymes are active with a range of transition metals. The parameters presented in this work provide a valuable resource for the molecular simulation community, as they extend the range of metal ions that can be studied using classical approaches, while also providing a starting point for subsequent parametrization of new metal centers.

    National Category
    Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-225523 (URN)10.1021/jp501737x (DOI)000335113600010 ()
    Funder
    Swedish National Infrastructure for Computing (SNIC), 2013/26-1
    Available from: 2014-06-23 Created: 2014-06-04 Last updated: 2017-07-02
    2. Expanding the catalytic triad in epoxide hydrolases and related enzymes
    Open this publication in new window or tab >>Expanding the catalytic triad in epoxide hydrolases and related enzymes
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    2015 (English)In: ACS Catalysis, ISSN 2155-5435, E-ISSN 2155-5435, Vol. 5, no 10, 5702-5713 p.Article in journal (Refereed) Published
    Abstract [en]

    Potato epoxide hydrolase 1 exhibits rich enantio- and regioselectivity in the hydrolysis of a broadrange of substrates. The enzyme can be engineered to increase the yield of optically pureproducts, as a result of changes in both enantio- and regioselectivity. It is thus highly attractive inbiocatalysis, particularly for the generation of enantiopure fine chemicals and pharmaceuticals.The present work aims to establish the principles underlying the activity and selectivity of theenzyme through a combined computational, structural, and kinetic study, using the substratetrans-stilbene oxide as a model system. Extensive empirical valence bond simulations have beenperformed on the wild-type enzyme together with several experimentally characterized mutants.We are able to computationally reproduce the differences in activities between differentstereoisomers of the substrate, and the effects of mutations in several active-site residues. Inaddition, our results indicate the involvement of a previously neglected residue, H104, which iselectrostatically linked to the general base, H300. We find that this residue, which is highlyconserved in epoxide hydrolases and related hydrolytic enzymes, needs to be in its protonatedform in order to provide charge balance in an otherwise negatively-charged active site. Our datashow that unless the active-site charge balance is correctly treated in simulations, it is notpossible to generate a physically meaningful model for the enzyme that can accurately reproduceactivity and selectivity trends. We also expand our understanding of other catalytic residues,demonstrating in particular the role of a non-canonical residue, E35, as a “backup-base” in theabsence of H300. Our results provide a detailed view of the main factors driving catalysis andregioselectivity in this enzyme, and identify targets for subsequent enzyme design efforts.

    National Category
    Biochemistry and Molecular Biology
    Research subject
    Biochemistry
    Identifiers
    urn:nbn:se:uu:diva-260232 (URN)10.1021/acscatal.5b01639 (DOI)000362391500006 ()
    Funder
    EU, FP7, Seventh Framework Programme, 306474Swedish Research Council, 621-2011-6055, 621-2010-5145Swedish National Infrastructure for Computing (SNIC), 2015/16-12
    Available from: 2015-08-18 Created: 2015-08-18 Last updated: 2017-07-02Bibliographically approved
    3. Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1
    Open this publication in new window or tab >>Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1
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    2016 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 14, no 24, 5639-5651 p.Article in journal (Refereed) Published
    Abstract [en]

    Potato epoxide hydrolase 1 (StEH1) is a biocatalytically important enzyme that exhibits rich enantio-and regioselectivity in the hydrolysis of chiral epoxide substrates. In particular, StEH1 has been demonstrated to enantioconvergently hydrolyze racemic mixes of styrene oxide (SO) to yield (R)-1-phenylethanediol. This work combines computational, crystallographic and biochemical analyses to understand both the origins of the enantioconvergent behavior of the wild-type enzyme, as well as shifts in activities and substrate binding preferences in an engineered StEH1 variant, R-C1B1, which contains four active site substitutions (W106L, L109Y, V141K and I155V). Our calculations are able to reproduce both the enantio-and regioselectivities of StEH1, and demonstrate a clear link between different substrate binding modes and the corresponding selectivity, with the preferred binding modes being shifted between the wild-type enzyme and the R-C1B1 variant. Additionally, we demonstrate that the observed changes in selectivity and the corresponding enantioconvergent behavior are due to a combination of steric and electrostatic effects that modulate both the accessibility of the different carbon atoms to the nucleophilic side chain of D105, as well as the interactions between the substrate and protein amino acid side chains and active site water molecules. Being able to computationally predict such subtle effects for different substrate enantiomers, as well as to understand their origin and how they are affected by mutations, is an important advance towards the computational design of improved biocatalysts for enantioselective synthesis.

    National Category
    Biochemistry and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-282015 (URN)10.1039/C6OB00060F (DOI)000378933400042 ()27049844 (PubMedID)
    Funder
    Swedish National Infrastructure for Computing (SNIC), 25/2-10EU, European Research Council, 306474;283570Swedish Research Council, 621-2011-6055Carl Tryggers foundation , CTS13:104
    Available from: 2016-04-01 Created: 2016-04-01 Last updated: 2017-07-02Bibliographically approved
    4. Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis
    Open this publication in new window or tab >>Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis
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    2016 (English)In: ChemBioChem (Print), ISSN 1439-4227, E-ISSN 1439-7633, Vol. 17, no 18, 1693-1697 p.Article in journal (Refereed) Published
    Abstract [en]

    Engineered enzyme variants of potato epoxide hydrolase (StEH1) display varying degrees of enrichment of (2R)-3-phenylpropane-1,2-diol from racemic benzyloxirane. Curiously, the observed increase in the enantiomeric excess of the (R)-diol is not only due to changes in enantioselectivity for the preferred epoxide enantiomer, but also to changes in the regioselectivity of the epoxide ring opening of (S)-benzyloxirane. To probe the structural origin of these differences in substrate selectivities and catalytic regiopreferences, we have solved the crystal structures for the in-vitro evolved StEH1 variants. We have additionally used these structures as a starting point for docking the epoxide enantiomers into the respective active sites. Interestingly, despite the simplicity of our docking calculations, the apparent preferred binding modes obtained from the docking appears to rationalize the experimentally determined regioselectivities. These calculations could also identify an active site residue (F33) as a putatively important interaction partner, a role that could explain the high degree of conservation of this residue during evolution. Overall, our combined experimental, structural and computational studies of this system provide snapshots into the evolution of enantioconvergence in StEH1 catalyzed epoxide hydrolysis.

    Keyword
    enantioselectivity; epoxide hydrolysis; evolutionary snapshots; laboratory evolution; protein engineering
    National Category
    Biochemistry and Molecular Biology
    Research subject
    Biochemistry
    Identifiers
    urn:nbn:se:uu:diva-298675 (URN)10.1002/cbic.201600330 (DOI)000384425400004 ()27383542 (PubMedID)
    Funder
    Swedish Research CouncilEU, European Research Council, 306474Swedish National Infrastructure for Computing (SNIC), SNIC2015-16-12EU, FP7, Seventh Framework Programme, 283570
    Available from: 2016-07-06 Created: 2016-07-06 Last updated: 2017-07-02Bibliographically approved
    5. Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme
    Open this publication in new window or tab >>Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme
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    (English)Article in journal (Other academic) Submitted
    National Category
    Biochemistry and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-325485 (URN)
    Available from: 2017-07-02 Created: 2017-07-02 Last updated: 2017-07-02
    6. Q Version 6, a comprehensive toolkit for empirical valence bond and related free energy calculations.
    Open this publication in new window or tab >>Q Version 6, a comprehensive toolkit for empirical valence bond and related free energy calculations.
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Chemistry Topics
    Identifiers
    urn:nbn:se:uu:diva-325490 (URN)
    Available from: 2017-07-02 Created: 2017-07-02 Last updated: 2017-07-03
  • Mattera, Andrea
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    nIGISOL 2016: Measurement of n-induced fission yields of tin and antimony2017Report (Other academic)
    Abstract [en]

    The first run of neutron-induced fission yields measurement at IGISOL-4 was performed from Friday December 9th to Monday December 12th, 2016.

    After mass separation of the fission products with the dipole magnets, ions were implanted on a movable tape and identified using γ-spectroscopy. Measurements were carried out using a Canberra GC7020 70% coaxial p-type HPGe detector.

    In this report, some details of the detector calibration and of the analysis procedure will be described.

  • Ahmedi, Lawen
    et al.
    Ali, Mubarak
    Castellanos, Larisa
    Tekniker för detektion av neutrier med ultrahög energi2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Wågberg, Felix
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Processförbättring inom appearance approval: En studie vid Scania CV AB i Södertälje2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Scania CV AB, Scania Commercial Vehicle Aktiebolag, is a production company that manufactures and supplies trucks, buses, engines, and services. Research and Development Unit, a major part of Scania's success, consisting of 3,500 employees, aims to continually develop, and improve high quality products and solutions. This project was carried out at the research and development department RCDA, which constantly work to determine the perceived quality of Scania’s trucks.

    The purpose of this thesis work was to identify improvement opportunities and suggest how these could be implemented on the chosen improvement area in the RCDA department. The aim of the work was to provide a literature study and deliver improvement proposals and its impact in an implementation plan. Assurance of the fulfilment concerning the above purpose and objectives were made with the following questions:How can processes in the subject of perceived quality on Scania be developed and improved?➢Which sub process affect the process concerning perceived quality?➢Which parts of the defined sub process can achieve significant improvements?➢What improvements in the defined sub process can be made?

    The answers to the questions were done through data collection that included observations, interviews, and a literature study. The project was defined subsequently with the data collection to the AAR-sub process Virtual AAR Evaluation. Which, after interviews and discussions with employees showed opportunities for concrete process improvements. Improvement areas such as working methods, communication and process structure were defined. Concrete solutions were then presented and supported with articles from the literaturestudy:➢Checklists for quality assurance➢Measurement of supplier performance➢Workflow management, provides structure and efficiency ➢Dialogical communication➢Transformative leadership

    The conclusion shows that implementation according to the plan presented may give rise to concrete improvements in the sub process virtual AAR evaluation through reduced resource utilization and quality assuring the process.

  • Nalwoga, Lillian
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Examining Agenda Setting Effects of Twitter Users during the 2016 Uganda Presidential Election2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The main aim of this thesis is to examine the agenda setting effects of Twitter users by exploring the use of hashtag #UgandaDecides and the retweet (RT) activity during the 2016 presidential election. I do this by applying the first level agenda setting theory which holds that the news media sets the public agenda.

    I apply a qualitative analysis using #UgandaDecides as a unit of analysis to collect tweets that received the most retweets to establish the actors tweeting during the study period. I conduct content analysis to establish the key issues/topics that received the most attention as per their level of frequency and prominence received through their retweet activity.

    Results in this thesis show that different actors were involved in determining the topics/issues on the twitter public agenda during the 2016 Uganda presidential election. For the pre-election period, the news media set the agenda by influencing the topics/issues for discussion as seen by the number of the retweets from their tweets. However, on Election Day, the public mainly ordinary citizens were more active in determining what topics/issues were discussed on Twitter, manifesting signs of reverse agenda setting.

    In this thesis, I thus conclude that Twitter can be empowering as it provides a space for ordinary citizens to participate in political discourse and that in a restrictive media environment, both media and public can use twitter as a participatory platform. The aspects of reversed agenda setting shown in this study are indicative of the changing media environment and how new power relations between different actors calls for the revision of the traditional agenda setting theory that the news media sets the public agenda.

  • Lind, Karin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy. Max Planck Inst Astron, Germany..
    Amarsi, A. M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany.;Australian Natl Univ, Res Sch Astron & Astrophys, Cotter Rd, Canberra, ACT 2611, Australia..
    Asplund, M.
    Australian Natl Univ, Res Sch Astron & Astrophys, Cotter Rd, Canberra, ACT 2611, Australia..
    Barklem, Paul S.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Bautista, M.
    Western Michigan Univ, Dept Phys, Kalamazoo, MI 49008 USA..
    Bergemann, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Collet, R.
    Aarhus Univ, Dept Phys & Astron, Stellar Astrophys Ctr, Ny Munkegade 120, DK-8000 Aarhus C, Denmark..
    Kiselman, D.
    Stockholm Univ, Albanova Univ Ctr, Dept Astron, Inst Solar Phys, SE-10691 Stockholm, Sweden..
    Leenaarts, J.
    Stockholm Univ, Albanova Univ Ctr, Dept Astron, Inst Solar Phys, SE-10691 Stockholm, Sweden..
    Pereira, T. M. D.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Non-LTE line formation of Fe in late-type stars - IV. Modelling of the solar centre-to-limb variation in 3D2017In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 468, no 4, 4311-4322 p.Article in journal (Refereed)
    Abstract [en]

    Our ability to model the shapes and strengths of iron lines in the solar spectrum is a critical test of the accuracy of the solar iron abundance, which sets the absolute zero-point of all stellar metallicities. We use an extensive 463-level Fe atom with new photoionization cross-sections for Fe I and quantum mechanical calculations of collisional excitation and charge transfer with neutral hydrogen; the latter effectively remove a free parameter that has hampered all previous line formation studies of Fe in non-local thermodynamic equilibrium (NLTE). For the first time, we use realistic 3D NLTE calculations of Fe for a quantitative comparison to solar observations. We confront our theoretical line profiles with observations taken at different viewing angles across the solar disc with the Swedish 1-m Solar Telescope. We find that 3D modelling well reproduces the observed centre-to-limb behaviour of spectral lines overall, but highlight aspects that may require further work, especially cross-sections for inelastic collisions with electrons. Our inferred solar iron abundance is log(epsilon(Fe)) = 7.48 +/- 0.04 dex.

  • Whittle, Thomas A.
    et al.
    Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Brant, William R.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry. Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Hester, James R.
    Australian Nucl Sci & Technol Org, Kirrawee DC, NSW 2253, Australia..
    Gu, Qinfen
    Australian Synchrotron, 800 Blackburn Rd, Clayton, Vic 3168, Australia..
    Schmid, Siegbert
    Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Tailoring phase transition temperatures in perovskites via A-site vacancy generation2017In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 46, no 22, 7253-7260 p.Article in journal (Refereed)
    Abstract [en]

    The structures across the Sr0.8Ti0.6-xZrxNb0.4O3, 0 <= x <= 0.6, defect perovskite series were investigated using complementary synchrotron X-ray and neutron powder diffraction data. The locations of second order compositional and temperature dependent phase transitions between the high symmetry cubic Pm (3) over barm phase and the lower symmetry tetragonal I4/mcm phase were determined. Deviation of the oxygen x coordinate from the high symmetry value and the B-O-B bond angle from 180 degrees as well as the tetragonal strain squared were each found to be suitable order parameters to monitor the transitions. Tolerance factor calculations confirmed that these A-site deficient perovskites retain a higher symmetry to a lower value than their fully occupied counterparts. Therefore, adjusting vacancy concentrations can be employed as a general strategy to design compounds with specifically tailored phase transition temperatures.