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  • Angermund, Malin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    The Computing Curriculum: En textanalys av rekommendationer för implementeringen av den nya läroplanen i England 20142018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sammanfattning

    Denna studie syftar till att problematisera och diskutera argument som ligger till grund för läroplansförändringar. I följande studie studeras rekommendationer som låg till grund för implementeringen av den nya läroplanen i England 2014, ”The computing curriculum”, då man önskade marknadsanpassa undervisningen inom digital teknik (digitalisering). Studien görs genom en kvalitativ textanalys av två rapporter skrivna 2011–2012. Rapporterna som analyserats är “Next Gen. Transforming the UK into  the world’s leading talent  hub for the video games  and visual effects industries” samt “Shut down or restart? The way forward for computing in UK schools”. För att uppnå syftet har följande frågeställningar formulerats:

     

    1. På vilka nivåer i skolsystemet läggs ansvaret i rekommendationerna?
    2. Finns det förslag på arbetsfördelning eller ekonomiska förutsättningar för att rekommendationerna skall kunna utföras?

     

    Resultatet som framkommit av analysen är att totalt 7 av de 21 analyserade rekommendationerna utgår från formuleringsarenan, 12 från transformeringsarenan och 2 från realiseringsarenan. I diskussionsdelen framkommer också att det i dessa rekommendationer finns förslag på arbetsfördelning och ekonomiska förutsättningar för att rekommendationerna skall kunna utföras.

  • Häggström, Kristina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    The Photographs of Alan Kurdi: Exploitative or Just What the Syrian Refugees Needed?2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Abstract:

    This study explores how the photographs of Alan Kurdi were used by Swedish newspapers, how they may have been perceived by the readers of those newspapers, and whether there are any ethical considerations when using the photography of Alan Kurdi. It answers three research questions; “How were the photographs of Alan Kurdi used by Swedish newspapers?”, “What potential meanings of the photographs of Alan Kurdi were interpreted by the readers of the articles?” and “What are the ethical implications of using the photographs of Alan Kurdi in the newspapers?” In order to investigate this the top 5 Swedish newspapers were studied and all the articles containing the photographs were studied. Through Sensitising Concepts and Inductive Analysis several topics and categories were discovered. The most common topic used by the newspapers was the topic of Alan Kurdi himself. In order to analyse these results Stuart Hall’s Encoding/Decoding Model of Communication is applied. The model identifies three types of receivers. Those who use preferred reading, negotiated reading and oppositional reading. By applying this model the way the photographs of Alan Kurdi was perceived by the readers of the newspapers can be analysed through the three different perspectives. Through the analysis it was argued that the most common way to perceive the photographs was humanising. The photographs worked both as an icon for the refugee crisis and to describe Alan Kurdi or the situation he was fleeing from. These topics can be argued to have a humanising effect on the refugee crisis as a whole. This was evident when charitable donations increased and there was a change in policy for refugees in Sweden that was less strict than before. However, after only a few months the public opinion grew harsher towards refugees and immigrants. This leads to the question - was it worth it? The photographs were used without consent and they could be argued to be exploitative of Alan Kurdi as well as his family. They can also be argued to be unethical. This papers concludes that the photographs were used by Swedish newspapers extensively, it seems in the most part with the intention of humanising the refugee crisis, and when looking at the rise in charitable donations and change in policy it seems to have worked. For a while. In truth, the photographs made no lasting difference, and it can be argued that the use of the photographs was unethical and the results that came from their publication did not justify the exploitation of Alan Kurdi.

  • Strömgren, Elias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    I ljuset av Skam: Om den norska tv-serien Skams påverkan på svenska elevers norska språkförståelse och språkattityder2017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    År 2016 vann den norska Tv-serien Skam Foreningen Nordens språkpris på grund av sin förmåga “[...] til å engasjere et ungt nordisk publikum, styrke forståelsen av skandinaviske språkvariasjoner og bygge opp positive holdninger til nabospråkene i Norden”. Men i vilken grad stämmer då detta?

    Denna uppsats har genom en enkätstudie i tre högstadieklasser i Uppsala undersökt niondeklassares norska ord- och läsförståelse, norska språkbruk och vilka attityder de har till Norge och norskan. Svaren har satts i förhållande till deras uppgivna konsumtion av tv-serien Skam.

    Resultaten bekräftar Foreningen Nordens påstående om Skams effekter. De som sett Skam har som grupp bättre norsk ord- och läsförståelse, använder till viss del norska ungdomsslang och har mer positiva attityder till Norge och norskan. Undersökningen har även visat att de informanter som inte talar svenska hemma eller som både talar svenska och ett annat språk hemma överlag har sämre norsk läsförståelse än de informanter som bara talar svenska hemma. Denna skillnad i språkförståelsen finns dock inte bland de informanter som sett Skam oavsett deras språkliga bakgrund.

    Uppsatsen har även ett didaktiskt perspektiv då den undersöker hur Skam kan användas i skolans norskundervisning i svenskämnet.

  • Rönnemo, Lina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Amor (im)possibilis: En komparativ analys mellan Carol av Patricia Highsmith och Maurice av E.M. Forster2017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Hedman Blomkvist, Nikolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    För nationella provet och höga betyg eller för yrkesliv och allmänbildning?: En läromedelsanalys av läromedel för yrkesprogram och högskoleförberedande program2017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I denna uppsats undersöks och jämförs två läromedel för kursen Svenska 1, varav ett är avsett för högskoleförberedande klasser och ett för yrkesförberedande. Uppsatsens syfte är att granska huruvida det finns innehållsliga skillnader mellan läromedlen och vad dessa i sådana fall kan bero på. Vidare är ett delsyfte att jämföra läromedlens innehåll med läroplanen och se huruvida eleverna har samma chans att nå målen oavsett läromedel. För att svara på uppsatsens syfte har en innehållsanalys använts för att systematiskt välja ut och bearbeta materialet. Läromedlen har kodats enligt olika slags skillnader, vilket gjorde att ett mönster i innehållsliga skillnader framkom. Undersökningen visar att det finns skillnader mellan läromedlen. Överlag är innehållet i yrkesboken förkortat och uteslutet i jämförelse med den högskoleförberedande läroboken. Den mer omfattande högskoleförberedande läroboken bör bidra med en bättre förberedelse för högre betyg. Uppsatsens slutsats är att läromedlen som undersökts har olika fokus och syfte, vilket medför konsekvenser för eleverna. De högskoleförberedande elevernas lärobok har ett tydligt fokus på kunskapskontroll och det nationella provet. Eleverna får omfattande information om de ämnesområden som behandlas och de får mycket detaljerande arbetsgångar för lärobokens slutuppgifter. Yrkeseleverna får mindre omfattande information om ämnesområden, sämre förberedelse för att genomföra slutuppgifterna i läroboken och inte samma förberedelse inför nationella provet. Istället förbereds yrkeseleverna för ett kommande yrkesliv och har tillägg av innehåll som verkar syfta till att vara roliga.

  • Maksimov, Vladimir
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
    Oya, Eriko
    Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
    Tanaka, Mayo
    Natl Inst Basic Biol, Div Chromatin Regulat, Okazaki, Aichi, Japan.
    Kawaguchi, Takayuki
    Natl Inst Basic Biol, Div Chromatin Regulat, Okazaki, Aichi, Japan;Inst Jacques Monod, Epigenet Regulat Genome Org, Paris, France.
    Hachisuka, Aki
    Natl Inst Basic Biol, Div Chromatin Regulat, Okazaki, Aichi, Japan;Univ Fukui, Dept Mat Sci & Biotechnol, Fukui, Japan.
    Ekwall, Karl
    Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden.
    Bjerling, Pernilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Nakayama, Jun-ichi
    Natl Inst Basic Biol, Div Chromatin Regulat, Okazaki, Aichi, Japan.
    The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 8, article id e0201101Article in journal (Refereed)
    Abstract [en]

    The binding of heterochromatin protein 1 (HP1) to lysine 9-methylated histone H3 (H3K9me) is an essential step in heterochromatin assembly. Chp2, an HP1-family protein in the fission yeast Schizosaccharomyces pombe, is required for heterochromatic silencing. Chp2 recruits SHREC, a multifunctional protein complex containing the nucleosome remodeler Mit1 and the histone deacetylase Clr3. Although the targeting of SHREC to chromatin is thought to occur via two distinct modules regulated by the SHREC components Chp2 and Clr2, it is not clear how Chp2's chromatin binding regulates SHREC function. Here, we show that H3K9me binding by Chp2's chromodomain (CD) is essential for Chp2's silencing function and for SHREC's targeting to chromatin. Cells expressing a Chp2 mutant with defective H3K9me binding (Chp2-W199A) have a silencing defect, with a phenotype similar to that of chp2-null cells. Genetic analysis using a synthetic silencing system revealed that a Chp2 mutant and SHREC-component mutants had similar phenotypes, suggesting that Chp2's function also affects SHREC's chromatin binding. Size-exclusion chromatography of native protein complexes showed that Chp2-CD's binding of H3K9me3 ensures Clr3's chromatin binding, and suggested that SHREC's chromatin binding is mediated by separable functional modules. Interestingly, we found that the stability of the Chp2 protein depended on the Clr3 protein's histone deacetylase activity. Our findings demonstrate that Chp2's H3K9me binding is critical for SHREC function and that the two modules within the SHREC complex are interdependent.

  • syala, fatma
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology, Centre for Social Work - CESAR.
    Bermal, Ronya
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology, Centre for Social Work - CESAR.
    Hedersrelaterat våld och förtryck: En diskursanalys om hur hedersrelaterat våld och förtryck framställs i svenska morgon- och kvällstidningar2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie syftar till att undersöka hur hedersrelaterat våld och förtryck framställs i svensk media. År 2002 hedersmördades den unga kvinnan Fadime – ett fall som ådrog sig stor uppmärksamhet i svenska dags- och kvällstidningar. Mot denna bakgrund analyseras i uppsatsen hur fenomenet hedersrelaterat våld och förtryck framställs strax efter Fadimes död 2002, hur det framställs idag (2017–2018), och vilka likheter och skillnader det finns i framställningarna mellan de olika tidsperioderna. Artiklar från dags- och kvällstidningar undersöks utifrån Faircloughs kritiska diskursanalys med hjälp av tre analytiska verktyg: modalitet, transitivitet och intertextualitet. Resultatet i denna studie visar att de dominerande diskurserna 2002 var kulturdiskursen, den globala kvinnoförtrycksdiskursen och hedersmordsdiskursen. De dominerande diskurserna 2017–2018 var kulturdiskursen, religionsdiskursen och förtrycks- och begränsningsdiskusen. Kulturdiskurserna 2002 och 2017–2018 uppvisade stora likheter, där den viktigaste skillnaden var att diskursen 2002 fokuserade mer specifikt på den kurdiska kulturen. I studien fann vi även att en viktig skillnad mellan de två perioderna var, att hedersmordsdiskursen (2002) numera ersatts av förtrycks- och begränsningsdiskursen (2017–2018), och att religionsdiskursen fått större utrymme under perioden 2017–2018. Kvinnoförtrycksdiskursens (2002) förklaring att hedersrelaterat våld och förtryck enbart kan förklaras av ett globalt kvinnoförtryck har i nutid delvis tonats ner, även om kvinnan fortfarande inom ramen för många olika diskurser framställs som offret.

  • Norell, Jens
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology, Centre for Social Work - CESAR.
    Holdor, David
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology, Centre for Social Work - CESAR.
    Bland ettor och nollor: En studie av nationell vägledning för den digitala socialtjänsten2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I denna studie undersöks nationell vägledning av implementeringen av e-tjänster inom socialtjänsten. Den teoretiska utgångspunkten är i socialkonstruktionismen med en inriktning på empowerment. Utifrån denna teoretiska grund har en kvalitativ textanalys genomförts av SKLs (Sveriges kommuner och landsting) (SKL 2013) vägledande dokument för implementering av etjänster inom socialtjänsten. I analysen av dokumentet har fokus lagts på att undersöka förekomsten av ett brukarperspektiv. Vidare har de rekommendationer som SKL presenterar till Sveriges kommuner granskats utifrån tidigare forskning. Denna studie har kommit fram till att det föreligger ett tydligt brukarperspektiv i dokumentet men att det i delar finns brister sett utifrån detsamma som tolkats som problematiska, framförallt avsaknad av problematisering kring vissa e-tjänster som presenteras.

  • Söderlund, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Transnational Corporations and Human Rights: Assessing the position of TNCs within international human rights law, and the appropriateness of an international treaty on business and human rights2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Transnational corporations are playing an important role in the global economy of today. Many of these corporations have great economic resources and have the possibility of contributing to the development of societies in developing states. At the same time, in their search for profit, the activities of TNCs have proven fatal to some of the individuals employed by them, or otherwise in contact with their activities. Within the international legal framework, corporations are not traditionally treated as subjects and if a TNC allocates its production to a state with lax human rights protection, no binding international standards exist to regulate the conduct of the corporation. 

    In my thesis I will assess the position of TNCs under the present core human rights instruments and soft law initiatives. I will also analyze a draft treaty text produced by the Intergovernmental Working Group on Business and Human Rights, released in July 2018, to reach a conclusion on whether such an instrument would affect the international legal status of TNCs and provide a more robust protection of international human rights.  

  • Kapari, Marianna
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Usability, accessibility andresponsive web design utilizingGoogle Maps API2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This Master’s thesis describes the development and evaluation of a responsive, map-based website intended to support book sharing in public places. The book sharing concept focuses on allowing a user to locate a book in a public place, register it online and share it again once they have finished reading it. In order to measure the usability of the website, two tests were conducted, which compared the website with another website for book sharing. The first test was conducted using questionnaires, with 24 participants, where as the second test focused on observations and interviews with four participants. Moreover, in order to measure the accessibility of the thesis website, an expert evaluation and an evaluation using accessibility evaluation tools were conducted. The results from the usability tests showed a need for improvements, for instance in the form of supporting documentation and addition of undo/redo options. The results of the expert review were positive while theresults ofthe accessibility tools showed compatibility issues depending on the browser that the website is accessed with.

  • Haulin, Lars
    A state-based method to model and analyze the power consumption of embedded systems2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this work I have evaluated a method to model, measure and analyze the power consumption of embedded systems.

    The method combines current measurement with debug trace data telling which parts of the systems that are enabled. This makes it possible to compute the individual current consumption of the parts in the system from a single measurement point.

    The method allows an embedded systems engineer to determine the power consumption of individual parts in a system to either get an overview or to compare several revisions of hardware and/or software with each other.

    The method also captures the system dynamics of the power delivery route. This makes the model consumption behave more like the actual system around state transitions.

    The case study is focused on the Arm-based microcontroller CC2650 from Texas Instruments and uses the I-scope/I-jet probe from IAR Systems to measure current consumption and collect trace data.

  • Lunev, Alexey
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Evaluation and visualization of complexity in parameter setting in automotive industry2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Parameter setting is a process primary used to specify in what kind of vehicle an electronic control unit of each type is used. This thesis is targeted to investigate whether the current strategy to measure complexity gives user satisfactory results. The strategy consists of structure-based algorithms that are an essential part of the Complexity Analyzer - a prototype application used to evaluate the complexity.     The results described in this work suggest that the currently implemented algorithms have to be properly defined and adapted to be used in terms of parameter setting. Moreover, the measurements that the algorithms output has been analyzed in more detail making the results easier to interpret.     It has been shown that a typical parameter setting file can be regarded as a tree structure. To measure variation in this structure a new concept, called Path entropy has been formulated, tested and implemented.     The main disadvantage of the original version of the Complexity Analyzer application is its lack of user-friendliness. Therefore, a web version of the application based on Model-View-Controller technique has been developed. Different to the original version it has user interface included and it takes just a couple of seconds to see the visualization of data, compared to the original version where it took several minutes to run the application.   

  • Lagali, Neil S.
    et al.
    Linkoping Univ, Inst Clin & Expt Med, Dept Ophthalmol, S-58183 Linkoping, Sweden;Sorlandet Hosp Arendal, Dept Ophthalmol, Arendal, Norway.
    Badian, Reza A.
    Oslo Univ Hosp, Dept Med Biochem, Unit Regenerat Med, N-0407 Oslo, Norway;Univ Oslo, N-0407 Oslo, Norway;Univ South Eastern Norway, Fac Visual & Hlth Sci, Natl Ctr Opt Vis & Eye Care, Kongsberg, Norway.
    Liu, Xu
    Oyelegesenteret Tromso, Fjaerevegen 6, N-9024 Tomasjord, Norway.
    Feldreich, Tobias R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.
    Arnlov, Johan
    Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Utheim, Tor Paaske
    Oslo Univ Hosp, Dept Med Biochem, Unit Regenerat Med, N-0407 Oslo, Norway;Univ Oslo, N-0407 Oslo, Norway;Sorlandet Hosp Arendal, Dept Ophthalmol, Arendal, Norway.
    Dahlin, Lars B.
    Lund Univ, Skane Univ Hosp, Dept Translat Med Hand Surg, S-20502 Malmo, Sweden.
    Rolandsson, Olov
    Umea Univ, Dept Publ Hlth & Clin Med, Family Med, S-90187 Umea, Sweden.
    Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 92018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 14248Article in journal (Refereed)
    Abstract [en]

    Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized that inflammatory changes in the eye may parallel the inflammation that develops with diabetes. Here, we developed a non-invasive means to monitor the status of inflammatory dendritic cell (DC) subsets in the corneal epithelium as a potential biomarker for the onset of inflammation in type 2 diabetes. In an age-matched cohort of 81 individuals with normal and impaired glucose tolerance and type 2 diabetes, DCs were quantified from wide-area maps of the corneal epithelial sub-basal plexus, obtained using clinical in vivo confocal microscopy (IVCM). With the onset of diabetes, the proportion of mature, antigen-presenting DCs increased and became organized in clusters. Out of 92 plasma proteins analysed in the cohort, tumor necrosis factor receptor super family member 9 (TNFRSF9) was associated with the observed maturation of DCs from an immature to mature antigen-presenting phenotype. A low-grade ocular surface inflammation observed in this study, where resident immature dendritic cells are transformed into mature antigen-presenting cells in the corneal epithelium, is a process putatively associated with TNFRSF9 signalling and may occur early in the development of type 2 diabetes. IVCM enables this process to be monitored non-invasively in the eye.

  • Jawed Masoor, Sina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    De afghanska kvinnliga ledamöternas upplevelser kring sina möjligheter och villkor inom parlamentet: 2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Aaboud, M.
    et al.
    LPTPM, Oujda, Morocco;Univ Mohamed Premier, Fac Sci, Oujda, Morocco.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Georg August Univ Gottingen, Phys Inst 2, Gottingen, Germany.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for charged Higgs bosons decaying via H-+/- -> tau(+/-)nu(tau) in the tau plus jets and tau plus lepton final states with 36 fb(-1) of pp collision data recorded at root s=13 TeV with the ATLAS experiment2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 9, article id 139Article in journal (Refereed)
    Abstract [en]

    Charged Higgs bosons produced either in top-quark decays or in association with a top-quark, subsequently decaying via H-+/-! -> tau(+/-)nu(tau), are searched for in 36.1 fb(-1) of proton-proton collision data at root s = 13TeV recorded with the ATLAS detector. Depending on whether the top-quark produced together with H-+/- decays hadronically or leptonically, the search targets tau+jets and tau+lepton fi nal states, in both cases with a hadronically decaying tau-lepton. No evidence of a charged Higgs boson is found. For the mass range of m(H)+/- = 90-2000 GeV, upper limits at the 95% con fi dence level are set on the production cross-section of the charged Higgs boson times the branching fraction B (H-+/-->tau(+/-)nu(tau)) in the range 4.2-0.0025 pb. In the mass range 90{160 GeV, assuming the Standard Model cross-section for tit production, this corresponds to upper limits between 0.25% and 0.031% for the branching fraction B (t -> bH(+/-)) x B (H-+/- -> tau(+/-)nu(tau)).

  • de Haas, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Riksrevisionens kris 2016: Ett fall av bristande förändringsarbete och ledarskap som hot mot professionens autonomi2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In 2016, the three Auditors General of the Swedish National Audit Office asked to be relieved of their positions after a period of intense criticism in the media. Swedish journalists had revealed that they all three had acted in ways that were not compatible with the office, and even in some cases against anti-corruption rules. However, it was also revealed that the staff resistance to the organisational change brought about by the three auditors had also contributed to the ongoing conflict within the agency. This paper aims to deepen the understanding of the situation within the agency and of how the change management methods used caused a conflict between the staff and the organisational leadership. I look into how the organisational transformation was accomplished and what the consequences were for performance auditors as a profession. The material consists primarily of interviews with employees of the performance audit department of the Swedish National Audit Office, and has been supplemented with independent audits of the organisational change within the agency and with media coverage. The material is analysed from the perspective of theories of change management as well as professionalism and new managerialism.

    The analysis of the gathered materials demonstrates that the change management and the resulting new working situation for the performance auditors was brought about through a leadership that ran roughshod over the professional needs and complaints of the performance auditors. It is highly likely that this is the critical reason for the crisis that occurred within the institution and later led to the resignation of the Auditors General. It seems, in fact, that the employees of the agency turned to media with compromising information because they wished to remove the leadership for other reasons. The outside pressure and lack of support from within the organisation made it then impossible for the auditors to continue in their positions.

  • Anter, Nora
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Partikulturer och politisk selektering: En kvantitativ studie av svenska kommunpolitiker2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Prior research has shown that the parties in the Swedish Riksdag demonstrate differences in party-culture, constituted by collective self-images and norms. The aim of this study is to investigate if politicians in the Swedish municipalities, from seven different parties, express the same party-culture as their counterparts in the Riksdag previously have. In addition, the study seeks to find out if adherence to the respective party-cultures have implications for the selection of politicians to top positions. Three themes of party-culture is studied, namely political ability, feelings of political responsibility and the party’s strength in relation to individual party members. The themes are investigated by studying a selection of data from the survey KOLFU 2012, which was addressed to all politicians in Sweden’s municipal and county councils. These data were studied mainly through regression analysis. The results demonstrate that there appears to be accordance between the party-cultures on the municipal level and the national level in several respects, but that adherence to party-culture does not generally matter for political selection to top positions. 

  • Paulraj, Alagar Raj
    et al.
    KTH Royal Inst Technol, Dept Chem Engn, SE-10044 Stockholm, Sweden.
    Kiros, Yohannes
    KTH Royal Inst Technol, Dept Chem Engn, SE-10044 Stockholm, Sweden.
    Göthelid, Mats
    KTH Royal Inst Technol, Mat Phys, SCI, S-16440 Kista, Sweden.
    Johansson, Malin B
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    NiFeOx as a Bifunctional Electrocatalyst for Oxygen Reduction (OR) and Evolution (OE) Reaction in Alkaline Media2018In: CATALYSTS, ISSN 2073-4344, Vol. 8, no 8, article id 328Article in journal (Refereed)
    Abstract [en]

    This article reports the two-step synthesis of NiFeOx nanomaterials and their characterization and bifunctional electrocatalytic activity measurements in alkaline electrolyte for metal-air batteries. The samples were mostly in layered double hydroxide at the initial temperature, but upon heat treatment, they were converted to NiFe2O4 phases. The electrochemical behaviour of the different samples was studied by linear sweep voltammetry and cyclic voltammetry on the glassy carbon electrode. The OER catalyst activity was observed for low mass loadings (0.125 mg cm(-2)), whereas high catalyst loading exhibited the best performance on the ORR side. The sample heat-treated at 250 degrees C delivered the highest bi-functional oxygen evolution and reduction reaction activity (OER/ORR) thanks to its thin-holey nanosheet-like structure with higher nickel oxidation state at 250 degrees C. This work further helps to develop low-cost electrocatalyst development for metal-air batteries.

  • Dorner, Thomas E.
    et al.
    Med Univ Vienna, Ctr Publ Hlth, Dept Social & Prevent Med, Kinderspitalgasse 15-1, A-1090 Vienna, Austria.
    Helgesson, Magnus
    Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Berzeliusv 3, S-17177 Stockholm, Sweden.
    Nilsson, Kerstin
    Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Berzeliusv 3, S-17177 Stockholm, Sweden.
    Pazarlis, Konstantinos A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Ropponen, Annina
    Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Berzeliusv 3, S-17177 Stockholm, Sweden;Finnish Inst Occupat Hlth, POB 18, Helsinki 00390, Finland.
    Svedberg, Pia
    Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Berzeliusv 3, S-17177 Stockholm, Sweden.
    Mittendorfer-Rutz, Ellenor
    Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Berzeliusv 3, S-17177 Stockholm, Sweden.
    Course and characteristics of work disability 3 years before and after lumbar spine decompression surgery: a national population-based study2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 11811Article in journal (Refereed)
    Abstract [en]

    Despite decompression surgery being a widespread intervention for patients with dorsopathies (i.e. back pain) affecting the lumbar spine, the scientific knowledge on patterns and characteristics of work disability before and after the surgery is limited. Sickness absence (SA) and disability pension (DP) were examined three years before and after surgery in 8558 patients aged 25-60 years who underwent lumbar spine decompression surgery in Sweden. They were compared to individuals with diagnosed dorsopathies but no surgery and individuals from the general population as matched comparison groups. According to Group Based Trajectory models, in patients with decompression surgery, 39% had low levels of SA/DP during the entire study period and 15% started with low levels of SA/DP, which increased in the year before, and declined to almost zero in the second year after surgery. Three trajectory groups (12%, 17%, and 18%) started at different levels of SA/DP, which increased in the years before, and declined in the third year after surgery. The trajectory groups in the comparison groups showed lower levels of work disability. Sex, education, and the use of antidepressants and analgesics the year before surgery played an important role to explain the variance of trajectory groups in patients with surgery.

  • Nordqvist, Pernilla
    et al.
    SIPRI, Solna, Sweden; University of Gothenburg, Gothenburg, Sweden.
    Krampe, Florian
    SIPRI, Solna, Sweden.
    Climate change and violent conflict: Sparse evidence from South Asia and South East Asia2018Report (Other academic)
    Abstract [en]

    The impacts of climate change are increasingly viewed as global security risks, which will have far-reaching implications for both human and renewable natural systems. Most climate–conflict research has focused on East Africa and sub-Saharan Africa. This SIPRI Insights explores and summarizes the findings from a systematic literature review of climate–conflict research on South Asia and South East Asia. Although these regions have been greatly affected by both climate change and conflict, there have only been a small number of rigorous academic studies that focus on the climate–conflict relationship.

    While this constrains the ability to draw general conclusions, there is context-specific evidence that climate change can have an effect on the causes and dynamics of violent conflict in the region when: (a) it leads to a deterioration in people’s livelihoods; (b) it influences the tactical considerations of armed groups; (c) elites use it to exploit social vulnerabilities and resources; and (d) it displaces people and increases levels of migration. In acknowledging that these mechanisms are often interlinked and more noticeable in some climatic, conflict and socio-economic contexts than in others, the need for more research in both regions is clear.

  • Haigh, Cathryn
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    The Political Discourse of the ‘New Age of Terror’:: An historical examination of the United Kingdom’s approach to counter-terrorism post-9/11 with a Critical Discourse Analysis observing how counter-terrorism strategies are framed to present a specific  narrative for the ‘new age of terror’.2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    At the start of his premiership UK Prime Minister, Tony Blair, spoke of ensuring that Britain continues with its proud history of multiculturalism by developing programmes to further integrate communities and reduce tensions resulting from immigration. Initially this programme was successful and many hailed the drive of New Labour in its desire to ensure that Britain sold itself as a welcoming place to call home. However, this celebration of success has been called into question over the first two decades of the new millennium following the seemingly steady increase in terrorist attacks and foiled attacks – many of which have been linked to British-born actors or immigrants to Britain. Thus, this study will call into question the extent to which the UKs multiculturalist approach has hit a stumbling block, positing that it is the change in approach to counter-terrorism through its Prevent programme that has led it to unlearn’ lessons from Northern Ireland and actively ensured a backward step through alienating the very communities it is trying to engage. It will examine the extent to which this seemingly more suspicious and divisive government-led approach alienates rather than celebrates cultural diversity, creating an environment ripe for radicalisation, in direct contrast to its aim, using Critical Discourse Analysis to show that the government’s approach from 2005 to the present day become entrenched as a result of the ‘new narrative’ of the ‘new age of terrorism’ and that this has led to a development of an ‘us’ versus ‘them’ approach which is not taking into account the necessary holistic approach to counter-terrorism, instead alienating Muslim communities and creating a hostile environment made worse by the permeation of suspicion from the general public who have bought into the narrative following more than a decade of its telling.

  • Aaboud, M.
    et al.
    LPTPM, Oujda, Morocco;Univ Mohamed Premier, Fac Sci, Oujda, Morocco.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Georg August Univ Gottingen, Phys Inst 2, Gottingen, Germany.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Combination of searches for heavy resonances decaying into bosonic and leptonic final states using 36 fb(-1) of proton-proton collision data at root s=13 TeV with the ATLAS detector2018In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 98, no 5, article id 052008Article in journal (Refereed)
    Abstract [en]

    Searches for new heavy resonances decaying into different pairings of W, Z, or Higgs bosons, as well as dirffiffiffiectly into leptons, are presented using a data sample corresponding to 36.1 fb(-1) of pp collisions at root s = 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting bosonic decay modes in the qqqq, vvqq, evqq, eeqq, evev, eevv, evee, eeee, qqbb, vvbb, evbb, and eebb final states are combined, searching for a narrow-width resonance. Likewise, analyses selecting the leptonic ev and ee final states are also combined. These two sets of analyses are then further combined. No significant deviation from the Standard Model predictions is observed. Three benchmark models are tested: a model predicting the existence of a new heavy scalar singlet, a simplified model predicting a heavy vector-boson triplet, and a bulk Randall-Sundrum model with a heavy spin-2 Kaluza-Klein excitation of the graviton. Cross section limits are set at the 95% confidence level using an asymptotic approximation and are compared with predictions for the benchmark models. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The data exclude a heavy vector-boson triplet with mass below 5.5 TeV in a weakly coupled scenario and 4.5 TeV in a strongly coupled scenario, as well as a Kaluza-Klein graviton with mass below 2.3 TeV.

  • Sidibeh, Cherno O
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Pereira, Maria J
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Abalo, Xesus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Boersma, Gretha J.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Skrtic, Stanko
    AstraZeneca R&D, Molndal, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.
    Lundkvist, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Katsogiannos, Petros
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Hausch, Felix
    Tech Univ Darmstadt, Inst Organ Chem & Biochem, Darmstadt, Germany.
    Castillejo-Lopez, Casimiro
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Eriksson, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes2018In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 62, no 1, p. 116-128Article in journal (Refereed)
    Abstract [en]

    Purpose Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in type 2 diabetes (T2D). Moreover, we assess the metabolic effects of reducing the activity of FKBP51 using the specific inhibitor SAFit1. Methods Human SAT was obtained by needle biopsies of the lower abdominal region. FKBP5 gene expression was assessed in fresh SAT explants from a cohort of 20 T2D subjects group-wise matched by gender, age and BMI to 20 nondiabetic subjects. In addition, human SAT was obtained from non-diabetic volunteers (20F/9M). SAT was incubated for 24 h with or without the synthetic glucocorticoid dexamethasone and SAFit1. Incubated SAT was used to measure the glucose uptake rate in isolated adipocytes. Results FKBP5 gene expression levels in SAT positively correlated with several indices of IR as well as glucose area under the curve during oral glucose tolerance test (r = 0.33, p < 0.05). FKBP5 gene expression levels tended to be higher in T2D subjects compared to non-diabetic subjects (p = 0.088). Moreover, FKBP5 gene expression levels were found to inversely correlate with lipolytic, lipogenic and adipogenic genes. SAFit1 partly prevented the inhibitory effects of dexamethasone on glucose uptake. Conclusions FKBP5 gene expression in human SAT tends to be increased in T2D subjects and is related to elevated glucose levels. Moreover, FKBP5 gene expression is inversely associated with the expression of lipolytic, lipogenic and adipogenic genes. SAFit1 can partly prevent glucose uptake impairment by glucocorticoids, suggesting that FKBP51 might be a key factor in glucocorticoid-induced IR.

  • Larsson, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Building a user interface with MATLAB Guide for MRI data volumes in Imiomics2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Bozorgi, Rozbe
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Åtgärdande av felkopplingar som kompensationsåtgärd för ökade dagvattenföroreningar: en fallstudie med en kostnads-nyttoanalys2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In 2015 the Weser Case resulted in a more stringent interpretation of the EU Water Framework Directive. For instance, the ruling stated that no projects should be given permission if even as little as one quality factor ends up with a lower status, regardless of how the other quality factors are affected. The stricter interpretation, combined with an increasing grade of urbanization, places higher demands on society’s management of wastewater and stormwater. One common way of ensuring the above requirements is to apply different solutions of best management practices for stormwater (BMP). The purpose of these solutions is to process the water as close to the source of origin as possible. However, in some cases it may be that there are more effective measures to ensure good water quality.

     

    A measure taken with the purpose of compensating for the absence of a different action is called a compensatory measure. In this thesis, the case of fixing incorrect connection of sewage pipes (where wastewater pipes have been incorrectly connected to stormwater pipes) was investigated as a compensatory measure for stormwater ponds (a common BMP). The prevailing legislation regarding compensatory measures was analysed and a case study has been conducted for Bällstaån. The case study included a cost-benefit analysis where the fixing of incorrectly-connected sewage pipes was compared with the implementation of stormwater ponds.

     

    The investigation regarding the legislative aspect showed that compensatory measures are a concept that can be interpreted somewhat differently. This has also been the case in the court over the years. However, current practice shows that a compensatory measure cannot be invoked to allow a project that otherwise would have been refused. Being able to use the fixing of incorrect connections as a compensation for BMP is thus, with today’s regulation, very unlikely.

     

    The case study showed that fixing incorrect connections in sewage pipes is, with regard to water quality, a far more cost-beneficial measure compared to the construction of stormwater ponds. Furthermore, the lack of studies regarding this kind of incorrect connections is, in the light of the results from the case study, probably an indication that this is a problem that fairly few people work with and where more resources could be a good investment for future water quality.

  • Public defence: 2018-11-09 09:00 BMC A1:111a, Uppsala
    Eriksson, Emma K.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Effects of Ubiquinone-10 on the Stability and Mechanical Properties of Lipid Membranes2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Ubiquinones are a group of fat-soluble molecules present in many biological membranes. The most abundant version in humans, ubiquinone-10 (Q10), plays an important role in the mitochondrial respiration chain and also functions as a powerful antioxidant. Accumulating evidence suggests that Q10 also could have other functions in the membrane. The aim of this thesis has been to explore Q10’s possible role as a membrane stabilizer.

    To investigate the potential effect of Q10 in membranes, liposomes with compositions of biological relevance were used as models systems. In lipid systems mimicking that of the inner membrane of the mitochondria, Q10 was found to lower the membrane’s permeability to hydrophilic solutes, render the membrane more resistant to rupturing and promote membrane lipid order. In models mimicking the plasma membrane of E.coli, Q10 was observed to decrease the water permeability and increase the elastic resistance against membrane deformation during osmotic shock. All in all, the results suggest a general membrane stabilizing effect of Q10. The results indicate, however, that the extent of, as well as the mechanisms behind, the membrane stabilizing effects of Q10 vary depending on the membrane lipid composition. Part of the reason for this can likely be traced back to differences in the intermembrane location of Q10.

    Supplementary experiments, which facilitated the investigations of Q10 membrane effects, revealed that the choice of cuvette material was of importance for liposome leakage experiments with fluorescent hydrophilic dyes. The results of these experiments highlight the need to take liposome-cuvette interactions into account when planning and evaluating spectroscopic studies involving liposomes.

    List of papers
    1. Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
    Open this publication in new window or tab >>Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
    2015 (English)In: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1848, no 10, p. 2233-2243Article in journal (Refereed) Published
    Abstract [en]

    Abstract Ubiquinone-10 is mostly known for its role as an electron and proton carrier in aerobic cellular respiration and its function as a powerful antioxidant. Accumulating evidence suggest, however, that this well studied membrane component could have several other important functions in living cells. The current study reports on a previously undocumented ability of ubiquinone-10 to modulate the mechanical strength and permeability of lipid membranes. Investigations of DPH fluorescence anisotropy, spontaneous and surfactant induced leakage of carboxyfluorescein, and interactions with hydrophobic and hydrophilic surfaces were used to probe the effects caused by inclusion of ubiquinone-10 in the membrane of phospholipid liposomes. The results show that ubiquinone in concentrations as low as 2&#xa0;mol.% increases the lipid packing order and condenses the membrane. The altered physicochemical properties result in a slower rate of release of hydrophilic components, and render the membrane more resistant towards rupture. As judged from comparative experiments using the polyisoprenoid alcohol solanesol, the quinone moiety is essential for the membrane stabilizing effects to occur. Our findings imply that the influence of ubiquinone-10 on the permeability and mechanical properties of phospholipid membranes is similar to that of cholesterol. The reported data indicate, however, that the molecular mechanisms are different in the two cases.

    Keywords
    Coenzyme Q10, Liposomes, Leakage, Membrane stability, Solanesol
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:uu:diva-253627 (URN)10.1016/j.bbamem.2015.05.002 (DOI)000362153400032 ()
    Funder
    Swedish Research Council, 621-2011-3524Swedish Cancer Society, CAN20111504
    Available from: 2015-05-29 Created: 2015-05-29 Last updated: 2018-09-23Bibliographically approved
    2. Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane.
    Open this publication in new window or tab >>Effect of ubiquinone-10 on the stability of biomimetic membranes of relevance for the inner mitochondrial membrane.
    2018 (English)In: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1860, no 5, p. 1205-1215Article in journal (Refereed) Published
    Abstract [en]

    Ubiquinone-10 (Q10) plays a pivotal role as electron-carrier in the mitochondrial respiratory chain, and is also well known for its powerful antioxidant properties. Recent findings suggest moreover that Q10 could have an important membrane stabilizing function. In line with this, we showed in a previous study that Q10 decreases the permeability to carboxyfluorescein (CF) and increases the mechanical strength of 1-palmitoyl-2-oleyl-sn-glycero-phosphocholine (POPC) membranes. In the current study we report on the effects exerted by Q10 in membranes having a more complex lipid composition designed to mimic that of the inner mitochondrial membrane (IMM). Results from DPH fluorescence anisotropy and permeability measurements, as well as investigations probing the interaction of liposomes with silica surfaces, corroborate a membrane stabilizing effect of Q10 also in the IMM-mimicking membranes. Comparative investigations examining the effect of Q10 and the polyisoprenoid alcohol solanesol on the IMM model and on membranes composed of individual IMM components suggest, moreover, that Q10 improves the membrane barrier properties via different mechanisms depending on the lipid composition of the membrane. Thus, whereas Q10's inhibitory effect on CF release from pure POPC membranes appears to be directly and solely related to Q10's lipid ordering and condensing effect, a mechanism linked to Q10's ability to amplify intrinsic curvature elastic stress dominates in case of membranes containing high proportions of palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE).

    Keywords
    Biomimetic membranes, Coenzyme Q10, Liposomes, Membrane stability, Solanesol
    National Category
    Biophysics
    Identifiers
    urn:nbn:se:uu:diva-353473 (URN)10.1016/j.bbamem.2018.02.015 (DOI)000435057700029 ()29470946 (PubMedID)
    Funder
    Swedish Research Council, 2016-03464Swedish Cancer Society, 17 0566
    Available from: 2018-06-13 Created: 2018-06-13 Last updated: 2018-09-23Bibliographically approved
    3. Osmo-protective effect of ubiquinone in lipid vesicles modelling the E.coli plasma membrane
    Open this publication in new window or tab >>Osmo-protective effect of ubiquinone in lipid vesicles modelling the E.coli plasma membrane
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Bacteria need to be able to adapt to sudden changes in their environment, including drastic changes in the surrounding osmolarity. Adjusting the composition of the cytoplasmic membrane is one strategy used by the cells to minimize changes in turgor pressure upon osmotic shock. Recent studies have shown that ubiquinones, lipid soluble molecules involved in cell respiration, are overproduced by bacteria grown in hyperosmotic conditions and it is thus believed that these molecules can provide with osmo-protection. Hereby we explore the mechanisms behind these observations. Liposomes with a lipid headgroup composition mimicking that of the cytoplasmic membrane of bacteria are used as suitable models. The effect of ubiquinone-10 (Q10) on water transport across the membranes is characterized using a custom developed fluorescence-based experimental approach to simultaneously determine the membrane permeability coefficient and estimate the elastic resistance of the membrane towards deformation. It is shown that both parameters are affected by the presence of ubiquinone-10. Solanesol, a molecule similar to Q10 but lacking the quinone headgroup, also provides with osmo-protection although it only improves the resistance of the membrane against deformation. The fluorescence experiments are complemented by cryogenic transmission electron microscopy studies showing that the bacterial membrane mimics tend to flatten into spheroid oblate structures when osmotically stressed, indicating lipid segregation. In agreement with its proposed osmo-protective role, the flattening process is hindered by the presence of Q10.

    National Category
    Natural Sciences
    Research subject
    Chemistry with specialization in Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-361360 (URN)
    Available from: 2018-09-23 Created: 2018-09-23 Last updated: 2018-09-23
    4. Choice of cuvette material can influence spectroscopic leakage and permeability experiments with liposomes.
    Open this publication in new window or tab >>Choice of cuvette material can influence spectroscopic leakage and permeability experiments with liposomes.
    2018 (English)In: Chemistry and Physics of Lipids, ISSN 0009-3084, E-ISSN 1873-2941, Vol. 215, p. 63-70, article id S0009-3084(18)30129-4Article in journal (Refereed) Published
    Abstract [en]

    Liposome solute permeability experiments are widely performed to gain information about lipid membrane characteristics. Spectroscopic methods are often used for this purpose, usually monitoring the leakage of a self-quenching fluorescent dye (e.g., carboxyfluorescein, CF) from the liposomes. Hereby, we investigate the effect of liposome-cuvette interactions, a seldom considered detail, on the results obtained from liposomal permeability experiments. The spontaneous leakage of CF from liposomes with different surface properties and phase states is followed using quartz and polystyrene cuvettes, and the results are compared. It is shown that for most lipid compositions the leakage profiles vary notably between different cuvette materials. Reproducibility of the measurements also varies depending on the cuvettes used, with polystyrene providing with more robust results. To explain these observations, the interaction of liposomes with polystyrene and quartz-like surfaces was characterized with the help of the quartz crystal microbalance with dissipation monitoring (QCM-D). Our results show that, while liposomes seldom interact with polystyrene, quartz-liposome interactions are almost unavoidable and have a large impact on the leakage experiments mainly via two mechanisms: i) the rupturing of liposomes on the cuvette surface causing a fast release of encapsulated CF, and ii) the disruption of adsorbed liposomes caused by magnetic stirring. Depending on their composition, the liposomes interact in different ways with quartz, affecting thus the extent of each proposed mechanism. The experiments demonstrate the importance of considering the cuvette material when planning and conducting spectroscopic experiments with liposomes.

    Keywords
    Carboxyfluorescein, Fluorescence, Polystyrene cuvettes, QCM-D, Quartz cuvettes, Spontaneous leakage
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:uu:diva-357926 (URN)10.1016/j.chemphyslip.2018.07.006 (DOI)30076799 (PubMedID)
    Available from: 2018-08-22 Created: 2018-08-22 Last updated: 2018-09-23
  • Salzmann, Talia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Cost analysis of dental caries prevention in Västerbotten county, Sweden: An investigation of preventive expenditure in a 5-year prospective cohort study in adolescents2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Introduction: Treatment of dental diseases makes up 4.6% of global health expenditure and dental caries is the most prevalent condition worldwide. In higher-income countries, population-wide prevention has brought prevalence down and it is now concentrated in 20% of the population. Currently the only single predictor of future caries is caries, meaning risk cannot be assessed before the disease is already present. Additionally, studies show different types of caries patients respond differently to prevention. As resources to provide dental services are limited, there is a need to understand what these different groups are and how we currently allocate resources to optimize prevention. It has been shown that the bacteria S. mutans is cariogenic and that there is a genetic component to caries risk. Methods: A prospective cohort study in Västerbotten County, Sweden identified genetic polymorphisms (i.e. mutations) which predispose to dental caries. This thesis calculated expenditure on caries prevention based on the dental records of this study and examined allocation between different risk groups according to observed risk, professionally estimated risk, genetic and bacterial risk (S. mutans). Results: Prevention costs are distributed rather equally regardless of professionally estimated, genetic or bacterial risk. Spending was overall low (median = 26 SEK). Discussion: Compared to other diseases, this annual expenditure is negligible. There is scope to increase this and focus it on highest-risk patients. For this, more research is needed to refine risk groups as well as the development of diagnostic tools to allow early detection and effective prevention.

  • Lingfors, David
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Widén, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Solenergipotentialen för Skånes bebyggelse enligt två framtidsscenarier2018Report (Other academic)
    Abstract [sv]

    Under de senaste åren har det skett en mycket snabb utbyggnad av solenergi i bebyggelsen i många länder, initialt i europeiska länder som Tyskland, Italien och Spanien men idag sker en snabb utveckling i de flesta länder i världen. I Sverige har användningen av solenergi tagit fart lite senare än i de södra grannländerna, mycket på grund av låga elkostnader från vatten- och kärnkraft. I samband med att investeringsstöd för solceller introducerades 2009 har dock solcellsmarknaden tagit fart om än från en låg nivå (se Figur 1). Från att solenergi framförallt nyttjats för uppvärmning eller för elgenerering vid fritidshuset eller båten sker nu installeringar av solcellsystem på framförallt villatak och lokaler i Sverige.För att möta både internationella såväl som lokala målsättningar att minskaklimatpåverkan är det viktigt att få en bild av potentialen för olika typer av förnybar energitillförsel. Den här studien är genomförd på uppdrag av Länsstyrelsen i Skåne med syfte att bedöma potentialen för solenergi på takytor inom hela länet, men även uppdelat på kommunnivå, både i närtid och med en längre tidshorisont. Utifrån trenden med sjunkande priser på solceller har potentialen för solvärme bedömts mycket liten, men kan delvis vara intressant för småhus.Potentialberäkningarna utgår från byggnadsbeståndet i fastighetskartan, uppdelat på olika byggnadstyper, där kvalificerade antaganden gjorts för vilken grad takytor för olika byggnadstyper kan utnyttjas för solenergi.Resultaten visar att det finns ungefär 105 km2 tillgänglig takyta för solenergi. Den realiserbara potentialen bedöms vara 3.1 TWh i scenario A samt 7.5 TWh i scenario B. Detta kan jämföras med elkonsumtionen i Skåne län som uppgick till 12.1 TWh 2014.

  • Public defence: 2018-11-09 10:15 Auditorium minus, Uppsala
    Haffenden, Chris
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History of Science and Ideas.
    Every Man His Own Monument: Self-Monumentalizing in Romantic Britain2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    From framing private homes as museums, to sitting for life masks and appointing biographers, new forms of self-monumentalizing emerged in the early nineteenth century. In this study I investigate the emergence and configuration of such practices in Romantic Britain. Positioning these practices at the intersection of emergent national pantheons, a modern conception of history, and a newly-formed celebrity culture, I argue that this period witnessed the birth of distinctively modern ways for the individual to make immortality. Faced with a visceral fear of being forgotten, public figures began borrowing from celebrity culture to make their own monuments.

    Concentrated upon early nineteenth-century London, I characterize these practices as attempts at self-made immortality.  I do so by analyzing the legacy projects of three well-known but seldom connected individuals: the Auto-Icon by the philosopher Jeremy Bentham (1748–1832), the Soane Museum by the architect Sir John Soane (1753–1837), and the life-writing efforts of the painter Benjamin Robert Haydon (1786–1846). Employing both sociological and materialist frameworks to analyze the making of immortality, I contend that these projects were characteristic of a novel regime for the production of lasting renown. Whereas earlier scholarship on Romantic recognition has tended to focus either on mass-media celebrity or the longer history of canon-formation, I highlight the interactions of celebrity and monument embodied in entrepreneurial efforts to secure future recognition.

    In Every Man His Own Monument, I demonstrate how a constellation of media forms and recording practices we now take for granted—the statuary figure, the house museum, and the published Life—assumed a central place within a new memorial regime. Bringing the historical roots of self-monumentalizing individuals to light, this study contributes to discussions both within the History of Celebrity and Cultural Memory Studies, and to broader debates regarding our Instagram-saturated present.

  • Public defence: 2018-11-09 13:15 Hörsal 2, Ekonomikum, Uppsala
    Wiell, Karolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Bad mot Lort och Sjukdom: Den privathygieniska utvecklingen i Sverige 1880–19492018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    In this thesis, the question of why a large number of small, modest, public baths (saunas) were built on the Swedish countryside during 1920–1949 has been analysed. The specific research question has been: How did the idea of the need for the baths, as well better personal hygiene among the Swedish population, develop? The study is based on a number of different sources, including governmental registers, records, and motions to parliament, reports from the organization of the district medical officers, popular science books, leaflets, schoolbooks and magazines.

    When bacteria were identified in the mid-19th century, the new knowledge spread around the world. In Sweden, the district medical officers made personal hygiene (skin care) a main question in the 1890s as a way of making their work important to their employer, Medicinalstyrelsen. It was also away to demonstrate their importance and unique competence when it came to preventive healthcare. The new knowledge, based on assembled health statistics and the idea of hygiene, was distributed to the population through literature such as schoolbooks, women’s magazines, and works of popular science, as well as through compulsory school baths for children. In the end, after almost 40 years, the arguments for personal hygiene formed an ideology that reached the government and resulted in a decision that supported the building boom of small public baths on the Swedish countryside, known as badstugor, to meet the need of an improved personal hygiene in areas where municipal water- and drainage systems were still not established.

    This study contributes to the understanding of personal and societal change. This study also focuses on how economics can be affected by help, adding to the field of economic history. Another aspect is how changes of norms, as well as strong beliefs, can lead to societal changes, new social norms and change behaviour of a population.

  • Bäcklin, Christofer L.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Gustafsson, Mats G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Developer-Friendly and Computationally Efficient Predictive Modeling without Information Leakage: The emil Package for R2018In: Journal of Statistical Software, ISSN 1548-7660, E-ISSN 1548-7660, Vol. 85, no 13, p. 1-30Article in journal (Refereed)
    Abstract [en]

    Data driven machine learning for predictive modeling problems (classification, regression, or survival analysis) typically involves a number of steps beginning with data preprocessing and ending with performance evaluation. A large number of packages providing tools for the individual steps are available for R, but there is a lack of tools for facilitating rigorous performance evaluation of the complete procedures assembled from them by means of cross-validation, bootstrap, or similar methods. Such a tool should strictly prevent test set observations from influencing model training and meta- parameter tuning, so- called information leakage, in order to not produce overly optimistic performance estimates. Here we present a new package for R denoted emil (evaluation of modeling without information leakage) that offers this form of performance evaluation. It provides a transparent and highly customizable framework for facilitating the assembly, execution, performance evaluation, and interpretation of complete procedures for classification, regression, and survival analysis. The components of package emil have been designed to be as modular and general as possible to allow users to combine, replace, and extend them if needed. Package emil was also developed with scalability in mind and has a small computational overhead, which is a key requirement for analyzing the very big data sets now available in fields like medicine, physics, and finance. First package emil's functionality and usage is explained. Then three specific application examples are presented to show its potential in terms of parallelization, customization for survival analysis, and development of ensemble models. Finally a brief comparison to similar software is provided.

  • Lugaj, Arjana
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Albania, a place where long-standing traditions devised a nation: The Kanun of Lek Dukagjini is alive and kicking2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Albania is a young democratic country that is still learning how to move forward. Albania has lived under regimes not democratically chosen for centuries: the Ottoman Empire before and the Communist regime than. These impositions have not allowed it to create an identity as a nation, this is the reason why they believe into the only code not forced from the high and that dates back to the Middle Age. The Kanun of Lëke Dukagjini is a customary code of laws that has ruled Albanians lives before the Ottoman Empire conquered the country. The Kanun influences everyday life still today. Albania remains tied to old traditions but on the other hand looks at the European Union as a role model. Albania is a country in between, traditions on one hand and progress on the other. The desire to be included in the Union has dramatically increased over the last decade. In these years, the government has been trying to satisfy the applications of Brussels hoping to get the candidacy. In 2014 Albania obtained the candidacy. Through the realization of laws in all fields, the government seems inclined to reach the standards of the European countries. In spite of all these progresses and changes, for Albanian population nothing seems different and everything appear just a way to show improvement to EU and EU countries but in everyday life it seems as same as always. It seems not possible to eradicate the mentality of citizens. Gender inequality and blood feuds are still a reality. The questions that guide this research are: how is it possible that a customary law is still so strongly present in Albanians lives? Is this a possible obstacle towards the European process of inclusion?

  • MEYER, Camille
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    “We are Europeans”: Perspectives of European citizenship and identity in the European Union and Argentina.2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The European Union is a supranational structure of its own, created to bring peaceafter years of war on the ground of shared economic interests. In the 1970s, the polity started torealize its need of a European identity to further pursue its integration process efficiently, openinga door on a whole new sphere. This latter shift brought new issues on the table, questioning thefeatures of a common identity bringing the European countries of the Union together andeventually introduced the concept of EU citizenship as a condition of (EU)ropean belonging. Onthe other side of the Atlantic, Argentina has been on the quest of its own identity since theindependence from Spain in 1810. In the twentieth century, the country started to identify withEurope, resulting in the creation of a European identity in a non-geographically Europeancontinent and far from the concept of EU citizenship. This thesis seeks to study the differentunderstandings of a European identity. The leading question is: How are European citizenshipand European identity interwoven in the expression of belonging to Europe in the officialdiscourse in the EU and Argentina? According to a model of the sociologist Delanty, we willdeconstruct the concept of citizenship according to three features and look at citizenship as acommunity of Rights, a participatory behaviour and an identity with means of culturalcohesiveness and historical traditions in both the EU and Argentina’s official discourse. Ourfindings show, neither the study of EU rights and participatory behaviour of Eu citizens inArgentina allow us to understand the identification of Argentina with Europe, in opposition withthe EU. Indeed, being a European in the EU refers to belonging and participating in a politicalsphere and eventually could lead to a political identity. In Argentina being European refers to acultural, if not eugenic identity which can be explained by the history of the country.

  • Milkina, Elena
    et al.
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Ponomarenko, Arina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Korneyko, Maria
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Lyakhova, Irina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Zayats, Yulia
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Zaitsev, Sergey
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Mischenko, Polina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Eliseikina, Marina
    RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Khotimchenko, Yuri
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Shevchenko, Valeryi
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;NN Blokhin Russian Canc Res Ctr, Moscow 115478, Russia.
    Sharma, Hari Shanker
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Bryukhovetskiy, Igor
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Interaction of hematopoietic CD34(+) CD45(+) stem cells and cancer cells stimulated by TGF-beta 1 in a model of glioblastoma in vitro2018In: Oncology Reports, ISSN 1021-335X, E-ISSN 1791-2431, Vol. 40, no 5, p. 2595-2607Article in journal (Refereed)
    Abstract [en]

    The majority of modern treatment methods for malignant brain tumors are not sufficiently effective, with a median survival time varying between 9 and 14 months. Metastatic and invasive processes are the principal characteristics of malignant tumors. The most important pathogenic mechanism is epithelial-mesenchymal transition (EMT), which causes epithelial cells to become more mobile, and capable of invading the surrounding tissues and migrating to distant organs. Transforming growth factor-beta 1 (TGF-beta 1) serves a key role in EMT-inducing mechanisms. The current study presented the interaction between hematopoietic stem cells and glioblastoma cells stimulated by TGF-beta 1 in vitro. The materials for the study were hematopoietic progenitor cell antigen CD34(+) hematopoietic stem cells (HSCs) and U87 glioblastoma cells. Cell culture methods, automated monitoring of cell-cell interactions, confocal laser microscopy, flow cytometry and electron microscopy were used. It was demonstrated that U87 cells have a complex communication system, including adhesive intercellular contacts, areas of interdigitation with dissolution of the cytoplasm, cell fusion, communication microtubes and microvesicles. TGF-beta 1 affected glioblastoma cells by modifying the cell shape and intensifying their exocrine function. HSCs migrated to glioblastoma cells, interacted with them and exchanged fluorescent tags. Stimulation of cancer cells with TGF-beta 1 weakened the ability of glioblastoma cells to attract HSCs and exchange a fluorescent tag. This process stimulated cancer cell proliferation, which is an indication of the ability of HSCs to 'switch' the proliferation and invasion processes in glioblastoma cells.

  • Larsson, Gunilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Samelands fria universitet.
    Contacts between Scandinavia and the Caucasus in Viking Age2013In: Between East and West: Early Contacts between Scandinavia and Caucasus / [ed] G. Larsson, Uppsala/Rimbo: Uppsala universitet, 2013, p. 49-61Chapter in book (Other academic)
  • Larsson, Gunilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Samelands fria universitet.
    Ingvar the Fartravellers journey: historical and archaeological sources2013In: Between East and West: Early Contacts between Scandinavia and Caucasus / [ed] G. Larsson, Uppsala/Rimbo: Uppsala universitet, 2013, p. 36-48Chapter in book (Other academic)
  • Larsson, Gunilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Revita Archaeology and History.
    Gállokjaure: Lämningar efter ett samiskt kulturlandskap. Rapport över arkeologisk utredning. Rapport 2012:12015Report (Other academic)
  • Larsson, Gunilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Samelands fria universitet.
    Ett par utspända stockbåtar från Roslagen2009In: Rospiggen, no 69Article in journal (Other (popular science, discussion, etc.))
  • Larsson, Gunilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Samelands fria universitet.
    Kvinnor till sjöss under vikingatid2010In: Rospiggen, no 70Article in journal (Other (popular science, discussion, etc.))
  • Johansson, Lars-Göran
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Logic and Metaphysics.
    Induction and Epistemological Naturalism2018In: Philosophies, ISSN 2409-9287, Vol. 3, no 4, article id 31Article in journal (Refereed)
  • Jiao, Mingzhi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Nguyen Viet, Chien
    Hanoi University of Science and Technology.
    Duy, Nguyen Van
    Hanoi University of Science and Technology.
    Nguyen Duc, Hoa
    Hanoi University of Science and Technology.
    Hieu, Nguyen Van
    Hanoi University of Science and Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Nguyen, Hugo
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Influence of annealing temperature on theperformance and stability of on-chip hydrothermally grown ZnO nanorod gassensor toward NO22018In: Academia Journal of Scientific Research, ISSN 2315-7712, Vol. 6, no 5, p. 180-189Article in journal (Refereed)
    Abstract [en]

    Nanorod-based gas sensors synthesized at low temperature should generally be stabilized by anneling before usage. However, the influence of annealing on the sensing performance and stability of these nanorods is rarely reported. In this study, we first fabricated gas sensors based on ZnO nanorods grown on-chip on glass substrate using hydrothermal method. Subsequently, these sensors were annealed at either 400 °C, 500 °C, or 600 °C in air for 4 h. The gas-sensing performance of the ZnO nanorods toward NO2 was tested before and after annealing. The sensitivity of the gas sensors to NO2 decreased, but the stability increased with the increase in annealing temperature. Photoluminescence spectroscopy and X-ray diffraction were used to investigate the material structure of ZnO nanorods. Results revealed that the oxygen-atom-related defects in the ZnO lattice in the region close to the surface influenced by annealing process were the most significant factors on the sensing properties and stability of ZnO nanorods.

  • Farrell, W. M.
    et al.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
    Hadid, Lina Z
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Morooka, Michiko
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Kurth, W. S.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Wahlund, Jan-Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    MacDowall, R. J.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
    Sulaiman, A. H.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Persoon, A. M.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Gurnett, D. A.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Saturn's Plasma Density Depletions Along Magnetic Field Lines Connected to the Main Rings2018In: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 45, no 16, p. 8104-8110Article in journal (Refereed)
    Abstract [en]

    We report on a set of clear and abrupt decreases in the high-frequency boundary of whistler mode emissions detected by Cassini at high latitudes (about +/- 40 degrees) during the low-altitude proximal flybys of Saturn. These abrupt decreases or dropouts have start and stop locations that correspond to L shells at the edges of the A and B rings. Langmuir probe measurements can confirm, in some cases, that the abrupt decrease in the high-frequency whistler mode boundary is associated with a corresponding abrupt electron density dropout over evacuated field lines connected to the A and B rings. Wideband data also reveal electron plasma oscillations and whistler mode cutoffs consistent with a low-density plasma in the region. The observation of the electron density dropout along ring-connecting field lines suggests that strong ambipolar forces are operating, drawing cold ionospheric ions outward to fill the flux tubes. There is an analog with the refilling of flux tubes in the terrestrial plasmasphere. We suggest that the ring-connected electron density dropouts observed between 1.1 and 1.3 R-s are connected to the low-density ring plasma cavity observed overtop the A and B rings during the 2004 Saturn orbital insertion pass.

    Plain Language Summary We present Cassini observations during the close passes by the planet Saturn indicating that plasma on magnetic field lines that pass through the A and B rings is of anomalously low density. These observations are consistent with the Saturn orbit insertion observations of a plasma cavity located at equatorial regions overtop the dense B ring. Using a terrestrial analogy, we suggest that the low-density conditions overtop the rings create an electrical force, called an ambipolar electric field that draws plasma out of the ionosphere in an attempt to replenish the plasma void found at equatorial regions.

  • Radonjic, Andja
    et al.
    Univ Belgrade, Fac Agr, Zemun Belgrade, Serbia;Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    Terenius, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology. Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    Ninkovic, Velemir
    Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    The phytopathogen powdery mildew affects food-searching behavior and survival of Coccinella septempunctata2018In: Arthropod-Plant Interactions, ISSN 1872-8855, E-ISSN 1872-8847, Vol. 12, no 5, p. 685-690Article in journal (Refereed)
    Abstract [en]

    The diet of entomophagous coccinellids is mainly based on aphids and other food sources such as pollen, nectar, or fungal spores. Knowledge of their foraging behavior on plants infected by powdery mildew and their survival on fungal spores is currently limited. In this study, we investigated the olfactory response of Coccinella septempunctata to odor emission of barley plants infected by powdery mildew and their survival on fungal spores in the presence or absence of aphids. Odors released by powdery-mildew infected plants were more attractive for ladybirds compared to those of uninfected controls. After 3days, the survival rate of ladybirds feeding only on powdery-mildew spores was less than 50%, while for ladybirds feeding exclusively on Rhopalosiphum padi aphids, the survival rate was close to 90%. After 15days, the highest survival rate (almost 80%) was observed for ladybirds feeding on plants with both aphids and powdery mildew. Molecular analyses confirmed the presence of fungal spores in ladybird guts when feeding either on powdery mildew or on a mixed diet. Our results provide new insights into foraging behavior of entomophagous coccinellids revealing the potential of powdery mildew to be utilized as important non-essential food in a mixed diet, but also its lethal effect if consumed alone.

  • Horio, M.
    et al.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Matt, C. E.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland;Harvard Univ, Dept Phys, Cambridge, MA 02138 USA;Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Kramer, K.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Sutter, D.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Cook, A. M.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Sassa, Yasmine
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Hauser, K.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Mansson, M.
    KTH Royal Inst Technol, Dept Appl Phys, Electrum 229, SE-16440 Stockholm, Sweden.
    Plumb, N. C.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Shi, M.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Lipscombe, O. J.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England.
    Hayden, S. M.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England.
    Neupert, T.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Chang, J.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Two-dimensional type-II Dirac fermions in layered oxides2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 3252Article in journal (Refereed)
    Abstract [en]

    Relativistic massless Dirac fermions can be probed with high-energy physics experiments, but appear also as low-energy quasi-particle excitations in electronic band structures. In condensed matter systems, their massless nature can be protected by crystal symmetries. Classification of such symmetry-protected relativistic band degeneracies has been fruitful, although many of the predicted quasi-particles still await their experimental discovery. Here we reveal, using angle-resolved photoemission spectroscopy, the existence of two-dimensional type-II Dirac fermions in the high-temperature superconductor La1.77Sr0.23CuO4. The Dirac point, constituting the crossing of d(x2-y2) and d(z2) bands, is found approximately one electronvolt below the Fermi level (E-F) and is protected by mirror symmetry. If spin-orbit coupling is considered, the Dirac point degeneracy is lifted and the bands acquire a topologically non-trivial character. In certain nickelate systems, band structure calculations suggest that the same type-II Dirac fermions can be realised near EF.

  • Säfstrom, Emma
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden; Nykoping Hosp, Sormland Cty Council, Nykoping, Sweden.
    Jaarsma, Tiny
    Linkoping Univ, Dept Social & Welf Studies, Linkoping, Sweden.
    Stromberg, Anna
    Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden;Linkoping Univ, Dept Cardiol, Linkoping, Sweden.
    Continuity and utilization of health and community care in elderly patients with heart failure before and after hospitalization2018In: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 18, article id 177Article in journal (Refereed)
    Abstract [en]

    Background: The period after hospitalization due to deteriorated heart failure (HF) is characterized as a time of high generalized risk. The transition from hospital to home is often problematic due to insufficient coordination of care, leading to a fragmentation of care rather than a seamless continuum of care. The aim was to describe health and community care utilization prior to and 30 days after hospitalization, and the continuity of care in patients hospitalized due to de novo or deteriorated HF from the patients' perspective and from a medical chart review. Methods: This was a cross-sectional study with consecutive inclusion of patients hospitalized at a county hospital in Sweden due to deteriorated HF during 2014. Data were collected by structured telephone interviews and medical chart review and analyzed with the Spearman's rank correlation coefficient and Chi square. A P value of 0. 05 was considered significant. Results: A total of 121 patients were included in the study, mean age 82.5 (+/- 6.8) and 49% were women. Half of the patients had not visited any health care facility during the month prior to the index hospital admission, and 79% of the patients visited the emergency room (ER) without a referral. Among these elderly patients, a total of 40% received assistance at home prior to hospitalization and 52% after discharge. A total of 86% received written discharge information, one third felt insecure after hospitalization and lacked knowledge of which health care provider to consult with and contact in the event of deterioration or complications. Health care utilization increased significantly after hospitalization. Conclusion: Most patients had not visited any health care facility within 30 days before hospitalization. Health care utilization increased significantly after hospitalization. Flaws in the continuity of care were found; even though most patients received written information at discharge, one third of the patients lacked knowledge about which health care provider to contact in the event of deterioration and felt insecure at home after discharge.

  • Mattsson, Sofia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Additivt tillverkade aluminiumkomponenter: Hållfasthetsegenskaper och materialkarakterisering2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Additive manufacturing, AM, is a general term for several different methods that aredefined by adding material instead of subtracting it as the traditional manufacturingmethods do. Being able to produce complex and high-strength metal componentsthrough AM has become an important research and development area in recentyears. This thanks to the short lead-time and increased level of complexity. AM ofmetal components is still a relatively new manufacturing method and there are someuncertainties regarding the process. This thesis considers the mechanical propertiesand material characterization of additive manufactured aluminum components fromthe powder AlSi10Mg. These components exhibit layer structure with a very fineunique microstructure. Due to the layer structure, test rods in two differentdirections were manufactured; vertical and horizontal, and analyzed in case of anyanisotropy occurrence. To investigate the mechanical properties and materialcharacterization of the two different AM test rods, fatigue properties, hardness andmicrostructure were analyzed and compared to traditional manufactured test rods ofaluminum alloy Al 6082-T6. This study has not been able to demonstrate that AMaluminum components would behave significantly differently (e.g. with respect to thecorrelation between fatigue resistance and tensile strength) than traditionallymanufactured components when exposed to fatigue stresses.

  • Barbolosi, Dominique
    et al.
    Crona, Joakim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Tumor Biology.
    Serre, Raphaël
    Pacak, Karel
    Taieb, David
    Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies.2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 8, article id e0201303Article in journal (Refereed)
    Abstract [en]

    Succinate dehydrogenase subunit B and D (SDHB and SDHD) mutations represent the most frequent cause of hereditary pheochromocytoma and paraganglioma (PPGL). Although truncation of the succinate dehydrogenase complex is thought to be the disease causing mechanism in both disorders, SDHB and SDHD patients exihibit different phenotypes. These phenotypic differences are currently unexplained by molecular genetics. The aim of this study is to compare disease dynamics in these two conditions via a Markov chain model based on 4 clinically-defined steady states. Our model corroborates at the population level phenotypic observations in SDHB and SDHD carriers and suggests potential explanations associated with the probabilities of disease maintenance and regression. In SDHB-related syndrome, PPGL maintenance seems to be reduced compared to SDHD (p = 0.04 vs 0.95) due to higher probability of tumor cell regression in SDHB vs SDHD (p = 0.87 vs 0.00). However, when SDHB-tumors give rise to metastases, metastatic cells are able to thrive with decreased probability of regression compared with SDHD counterparts (p = 0.17 vs 0.89). By constrast, almost all SDHD patients develop PGL (mainly head and neck) that persist throughout their lifetime. However, compared to SDHB, maintenance of metastatic lesions seems to be less effective for SDHD (p = 0.83 vs 0.11). These findings align with data suggesting that SDHD-related PPGL require less genetic events for tumor initiation and maintenance compared to those related to SDHB, but fail to initiate biology that promotes metastatic spread and metastatic cell survival in host tissues. By contrast, the higher number of genetic abnormalities required for tumor initiation and maintenance in SDHB PPGL result in a lower penetrance of PGL, but when cells give rise to metastases they are assumed to be better adapted to sustain survival. These proposed differences in disease progression dynamics between SDHB and SDHD diseases provide new cues for future exploration of SDHx PPGL behavior, offering considerations for future specific therapeutic and prevention strategies.

  • Public defence: 2018-11-09 10:15 Sydney Alrutz, Uppsala
    Forslund, Tommie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University, department of psychology.
    Disorganized Attachment Representations, Externalizing Behavior Problems, and Socio-Emotional Competences2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Disorganized attachment is a risk-factor for developmental maladaptation in the form of externalizing behavior problems, and for poor development of competences important for socio-emotional functioning. Concerns have however been raised regarding theoretical overextension, and there is consequently a need for multifactorial studies that examine which outcomes disorganized attachment is reliably important for. There is also a lack of research on the mechanisms that mediate the relation between disorganized attachment and externalizing problems. The present thesis therefore examined whether disorganized attachment is a specific risk-factor for symptoms of Oppositional Defiant Disorder (ODD) or Attention-Deficit/Hyperactivity Disorder (ADHD), or a non-specific risk factor for both types of problems. Several emotional and cognitive competences were investigated as mediators, with the question of whether disorganized attachment becomes associated with externalizing problems primarily through any specific mechanism, or through multiple mechanisms. Three studies were conducted. Children completed the separation anxiety test for attachment representations and laboratory tasks for distinct competences, and parents and teachers rated emotion regulation and ODD- and ADHD-symptoms. Study I was cross-sectional and found that disorganized attachment contributed specifically to conduct problems when accounting for ADHD-symptoms. However, disorganized attachment did not contribute to ADHD-symptoms when accounting for conduct problems. Study II found that children with disorganized attachment representations show deviations in identification of emotional expressions, in the form of a generally diminished ability to discriminate between expressions rather than in response biases. Study III was (short-term) longitudinal and replicated the results from Study I; disorganized attachment was primarily associated with ODD-symptoms, not ADHD-symptoms. Elevated emotional reactivity and poor regulation, particularly for anger and fear, mediated the relation between disorganized attachment and ODD-symptoms. Taken together, the present findings suggest that disorganized attachment may constitute a specific risk factor for externalizing problems pertaining to anger and aggression, such as oppositionality and misconduct, rather than ADHD-problems. Importantly, the findings caution against ideas of a pathway from disorganized attachment to ADHD-symptoms. The deviations in processing and regulation of anger and fear corroborate Bowlby´s proposal that these emotions are closely connected, central to disorganization, and a potential mediating mechanism in relation to externalizing problems.

    List of papers
    1. The Heterogeneity of ADHD Symptoms and Conduct Problems: Cognitive Inhibition, Emotion Regulation, Emotionality and Disorganized Attachment
    Open this publication in new window or tab >>The Heterogeneity of ADHD Symptoms and Conduct Problems: Cognitive Inhibition, Emotion Regulation, Emotionality and Disorganized Attachment
    Show others...
    2016 (English)In: British Journal of Developmental Psychology, ISSN 0261-510X, E-ISSN 2044-835X, Vol. 34, no 3, p. 371-387Article in journal (Refereed) Published
    Abstract [en]

    This study examined the contributions of several important domains of functioning to attention-deficit/hyperactivity disorder (ADHD) symptoms and conduct problems. Specifically, we investigated whether cognitive inhibition, emotion regulation, emotionality, and disorganized attachment made independent and specific contributions to these externalizing behaviour problems from a multiple pathways perspective. The study included laboratory measures of cognitive inhibition and disorganized attachment in 184 typically developing children (M age = 6 years, 10 months, SD = 1.7). Parental ratings provided measures of emotion regulation, emotionality, and externalizing behaviour problems. Results revealed that cognitive inhibition, regulation of positive emotion, and positive emotionality were independently and specifically related to ADHD symptoms. Disorganized attachment and negative emotionality formed independent and specific relations to conduct problems. Our findings support the multiple pathways perspective on ADHD, with poor regulation of positive emotion and high positive emotionality making distinct contributions to ADHD symptoms. More specifically, our results support the proposal of a temperamentally based pathway to ADHD symptoms. The findings also indicate that disorganized attachment and negative emotionality constitute pathways specific to conduct problems rather than to ADHD symptoms.

    Keywords
    attention-deficit/hyperactivity disorder, cognitive inhibition, conduct problems, disorganized attachment, emotion regulation, emotionality
    National Category
    Social Sciences
    Identifiers
    urn:nbn:se:uu:diva-283742 (URN)10.1111/bjdp.12136 (DOI)000380721800005 ()26895773 (PubMedID)
    Funder
    Swedish Research Council, 412-2008-2401
    Available from: 2016-04-14 Created: 2016-04-14 Last updated: 2018-09-24Bibliographically approved
    2. Diminished ability to identify facial emotional expressions in children with disorganized attachment representations
    Open this publication in new window or tab >>Diminished ability to identify facial emotional expressions in children with disorganized attachment representations
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    2016 (English)In: Developmental Science, ISSN 1363-755X, E-ISSN 1467-7687, Vol. 20, no 6, article id e12465Article in journal (Refereed) Published
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-310371 (URN)10.1111/desc.12465 (DOI)000413901000011 ()
    Funder
    Swedish Research Council, 412-2012-1222
    Available from: 2016-12-14 Created: 2016-12-14 Last updated: 2018-09-24Bibliographically approved
    3. Disorganized Attachment, Externalizing Behavior Problems, and Socioemotional Competences in early School-Age
    Open this publication in new window or tab >>Disorganized Attachment, Externalizing Behavior Problems, and Socioemotional Competences in early School-Age
    (English)In: Article in journal (Refereed) Submitted
    Place, publisher, year, edition, pages
    Uppsala:
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-361362 (URN)
    Available from: 2018-09-24 Created: 2018-09-24 Last updated: 2018-09-24
  • Fredriksson, Maria
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Henningsson, Annika
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Flipped Classroom med gamification som stöd för studentaktiverande undervisningsform2017Conference paper (Other academic)
  • Storlund, Brita
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Jourreformen i Finland: En analys av språkdebatten2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis