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  • Public defence: 2019-06-13 10:15 E22, Visby
    Eriksson, Ola
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Numerical Computations of Wakes Behind Wind Farms: A tool to study Farm to Farm interaction2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    More and larger wind farms are planned offshore. As the most suitable sites to build are limited these new wind farms will be constructed near to each other in so called wind farm clusters. Behind the wind turbines in these farms there is a disrupted flow of air called a wake that is characterized by reduced wind speed and increased turbulence. These individual turbine wakes combine to form a farm wake that can travel long distances. In wind farm clusters farm to farm interaction will occur, i.e. the long distance wake from one wind farm will impact the wind conditions for other farms in the surrounding area.

    This thesis contains numerical studies of these long distance wakes. In these studies Large Eddy Simulations (LES) using an Actuator Disc method (ACD) are used. A prescribed boundary layer is used where the wind shear is introduced using body forces. The turbulence, based on the Mann model, is introduced as fluctuating body forces upstream of the farm. A neutral atmosphere is assumed. The applied method has earlier been used for studies of wake effects inside farms but not for the longer distances needed for the study of farm to farm interaction. Parameter studies are setup to analyze how to best use the model for the study of long distance wakes with regards to 1) numerical and physical parameters in the model, 2) the extension of the domain and turbulence as well as the characteristics of the flow far downstream and 3) the downstream development of turbulence with different combinations of wind shear and turbulence level.

    Using an initial simulation setup a wind farm was studied and preliminary results were obtained. These results were subsequently improved upon by applying the simulation setup adjustments indicated in the parameter studies. A comparison with a mesoscale model was also done. The mesoscale model was shown to be relevant for studies of long distance wakes in another study comparing LES and WRF. Finally an idealized farm to farm interaction case was studied with focus on the impact of including the Coriolis force in the simulations.

    Combining LES with a mesoscale model is of interest to study further.

    List of papers
    1. Large-eddy simulations of the evolution of imposed turbulence in forced boundary layers in a very long domain
    Open this publication in new window or tab >>Large-eddy simulations of the evolution of imposed turbulence in forced boundary layers in a very long domain
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-379122 (URN)
    Available from: 2019-03-12 Created: 2019-03-12 Last updated: 2019-03-18
    2. Large-eddy simulations of wind farm production and long distance wakes
    Open this publication in new window or tab >>Large-eddy simulations of wind farm production and long distance wakes
    2015 (English)In: Wake Conference 2015, 2015, p. 012022-, article id 012022Conference paper, Published paper (Refereed)
    Abstract [en]

    The future development of offshore wind power will include many wind farms built in the same areas. It is known that wind farms produce long distance wakes, which means that we will see more occasions of farm to farm interaction, namely one wind farm operating in the wake of another wind farm. This study investigates how to perform accurate power predictions on large wind farms and how to assess the long distance wakes generated by these farms. The focus of this paper is the production's and wake's sensitivity to the extension of the grid as well as the turbulence when using Large-eddy simulations (LES) with pregenerated Mann turbulence. The aim is to determine an optimal grid which minimizes blockage effects and ensures constant resolution in the entire wake region at the lowest computational cost. The simulations are first performed in the absence of wind turbines in order to assess how the atmospheric turbulence and wind profile are evolving downstream (up to 12,000 m behind the position where the turbulence is imposed). In the second step, 10 turbines are added in the domain (using an actuator disc method) and their production is analyzed alongside the mean velocities in the domain. The blockage effects are tested using grids with different vertical extents. An equidistant region is used in order to ensure high resolution in the wake region. The importance of covering the entire wake structure inside the equidistant region is analyzed by decreasing the size of this region. In this step, the importance of the lateral size of the Mann turbulence box is also analyzed. In the results it can be seen that the flow is acceptably preserved through the empty domain if a larger turbulence box is used. The relative production is increased (due to blockage effects) for the last turbines using a smaller vertical domain, increased for a lower or narrower equidistant region (due to the smearing of the wake in the stretched area) and decreased when using a smaller turbulence box (due to decreased inmixing) The long distance wake behind the row is most impacted by the use of a smaller turbulence box, while the other simulation setups have less influence on these results. In summary, the results show the importance of having relatively large extensions of the domain, large extensions of the equidistant region and especially large extensions of the turbulence box.

    Series
    Journal of Physics Conference Series, ISSN 1742-6588 ; 625
    National Category
    Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-261143 (URN)10.1088/1742-6596/625/1/012022 (DOI)000358047700022 ()
    Conference
    Wake Conference, JUN 09-11, 2015, Visby, SWEDEN
    Funder
    Swedish National Infrastructure for Computing (SNIC)StandUp for Wind
    Available from: 2015-08-31 Created: 2015-08-31 Last updated: 2019-03-18Bibliographically approved
    3. Analysis of long distance wakes behind a row of turbines – a parameter study
    Open this publication in new window or tab >>Analysis of long distance wakes behind a row of turbines – a parameter study
    2014 (English)In: Science of Making Torque from Wind, 2014, p. 012152-Conference paper, Published paper (Refereed)
    Abstract [en]

    Large Eddy Simulations (LES) of the long distance wake behind a row of 10 turbines are conducted to predict wake recovery. The Navier-Stokes solver EllipSys3D is used in combination with the actuator disc concept. Neutral atmospheric conditions are assumed in combination with synthetic turbulence using the Mann method. Both the wind shear profile and turbulence are introduced into the flow field using body forces. Previous simulations using the same simulation method to model the Horns Rev wind farm showed a higher wake recovery at long distances compared to measurements. The current study investigates further the sensitivity to parameters such as the grid resolution, Reynolds number, the turbulence characteristics as well as the impact of using different internal turbine spacings. The clearest impact on the recovery behind the farm could be seen from the background turbulence. The impact of the wind shear on the turbulence level in the domain needs further studies. A lower turbulence level gives lower wake recovery as expected. A lower wake recovery can also be seen for a higher grid resolution. The Reynolds number, apart from when using a very low value, has a small impact on the result. The variation of the internal spacing is seen to have a relatively minor impact on the farm wake recovery.

    Series
    Journal of Physics Conference Series, ISSN 1742-6588 ; 524
    National Category
    Physical Sciences Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-237704 (URN)10.1088/1742-6596/524/1/012152 (DOI)000344193600152 ()
    Conference
    5th Science of Making Torque from Wind Conference, JUN 18-20, 2014, Tech Univ Denmark, Copenhagen, DENMARK
    Funder
    Swedish National Infrastructure for Computing (SNIC)StandUp for Wind
    Available from: 2014-12-04 Created: 2014-12-04 Last updated: 2019-03-18Bibliographically approved
    4. Analysis of long distance wakes of Horns Rev 1 using actuator disc approach
    Open this publication in new window or tab >>Analysis of long distance wakes of Horns Rev 1 using actuator disc approach
    Show others...
    2014 (English)In: Journal of Physics: Conference Series, ISSN 1742-6588, Vol. Vol. 555, no nr 1, article id 012032Article in journal (Refereed) Published
    Abstract [en]

    The wake recovery behind the Horns Rev wind farm is analysed to investigate the applicability of Large Eddy Simulations (LES) in combination with an actuator disc method (ACD) for farm to farm interaction studies. Periodic boundary conditions on the lateral boundaries are used to model the wind farm (as infinitely wide), using only two columns of turbines. The meteorological conditions of the site are taken into account by introducing wind shear and pre-generated synthetic turbulence to the simulation domain using body forces. Simulations are carried out to study the power production and the velocity deficit in the farm wake. The results are compared to the actual power production as well as to wind measurements at 2 km and 6 km behind the wind farm. The simulated power production inside the farm shows an overall good correlation with the real production, but is slightly overpredicted in the most downstream rows. The simulations overpredict the wake recovery, namely the wind velocity, at long distances behind the farm. Further studies are needed before the presented method can be applied for the simulation of long distance wakes. Suggested parameters to be studied are the development of the turbulence downstream in the domain and the impact of the grid resolution.

    National Category
    Energy Engineering
    Identifiers
    urn:nbn:se:uu:diva-238304 (URN)
    Conference
    The Science of making Torque from Wind, Oldenburg
    Funder
    Swedish National Infrastructure for Computing (SNIC), SNIC 001/11-99StandUp for Wind
    Available from: 2014-12-11 Created: 2014-12-11 Last updated: 2019-03-18
    5. Wake downstream of the Lillgrund wind farm - A Comparison between LES using the actuator disc method and a Wind farm Parametrization in WRF
    Open this publication in new window or tab >>Wake downstream of the Lillgrund wind farm - A Comparison between LES using the actuator disc method and a Wind farm Parametrization in WRF
    2015 (English)In: WAKE CONFERENCE 2015, 2015, p. 012028-, article id 012028Conference paper, Published paper (Refereed)
    Abstract [en]

    Simulations of the Lillgrund wind farm (located between Malmo and Copenhagen) are performed using both Large Eddy Simulation (LES) and mesoscale simulations in WRF. The aim is to obtain a better understanding of wakes generated by entire wind farms in order to improve the understanding of farm to farm interactions. The study compares the results from the two used models for the energy production and the wake characteristics downstream of the wind farm. A comparison is also performed with regards to the production data from the Lillgrund wind farm which has been filtered to be comparable to the case used in the simulations. The studied case, based on a prerun in WRF without any wind farm, has an inflow angle of 222 +/- 2.5 deg, a wind speed at hub height of 9.8 m/s and a near neutral atmosphere. A logarithmic wind shear is used in LES and the turbulence intensity is 5.9%. The WRF simulations use a parameterization for wind farms. The wind farm is treated by the model as a sink of the resolved atmospheric momentum. The total energy extraction and the electrical power are respectively proportional to specified thrust and power coefficients. The generated turbulent kinetic energy are the difference between the total and the electrical power. The LES are performed using the EllipSys3D code applying the actuator disc methodology for representing the presence of the rotors. Synthetic atmospheric turbulence is generated with the Mann model. Both the atmospheric turbulence and the wind shear are introduced using body forces. The production was found to be better estimated in LES. WRF show a slightly higher recovery behind the farm. The internal boundary layer is for the compared simulation setups higher in LES while the wake expansion is about the same in both models. The results from the WRF parameterization could potentially be improved by increasing the grid resolution. For farm to farm interaction a combination of the two methods is found to be of interest.

    Series
    Journal of Physics Conference Series, ISSN 1742-6588 ; 625
    National Category
    Energy Engineering
    Identifiers
    urn:nbn:se:uu:diva-261142 (URN)10.1088/1742-6596/625/1/012028 (DOI)000358047700028 ()
    Conference
    Wake Conference, JUN 09-11, 2015, Visby, SWEDEN
    Funder
    Swedish National Infrastructure for Computing (SNIC)StandUp for Wind
    Available from: 2015-08-31 Created: 2015-08-31 Last updated: 2019-03-18Bibliographically approved
    6. Impact of Wind Veer and the Coriolis Force for an Idealized Farm to Farm Interaction Case
    Open this publication in new window or tab >>Impact of Wind Veer and the Coriolis Force for an Idealized Farm to Farm Interaction Case
    2019 (English)In: Applied Sciences, E-ISSN 2076-3417, Vol. 9, no 5, article id 922Article in journal (Refereed) Published
    Abstract [en]

    The impact of the Coriolis force on the long distance wake behind wind farms is investigated using Large Eddy Simulations (LES) combined with a Forced Boundary Layer (FBL) technique. When using the FBL technique any mean wind shear and turbulent fluctuations can be added with body forces. The wind shear can also include the mean wind veer due to the Coriolis force. The variation of the Coriolis force due to local deviations from the mean profile, e.g., from wakes, is not taken into account in the FBL. This can be corrected for with an extra source term in the equations, hereon defined as the Coriolis correction. For a row of 4 turbines it is shown that the inclusion of the wind veer turns the wake to the right, while including the Coriolis correction turns it to the left. When including both wind veer and Coriolis correction the impact of wind veer dominates. For an idealized farm to farm interaction case, two farms of 4 * 4 turbines with 6 km in between, it can be seen that when including wind veer and the Coriolis correction a approximately 3% increase in the relative production for a full wake direction can be seen and only a slightly smaller increase can be seen when including only wind veer. The results indicate that FBL can be used for studies of long distance wakes without including a Coriolis correction but efforts need to be taken to use a wind shear with a correct mean wind veer.

    Keywords
    long distance wake, farm to farm interaction, wind farm cluster, large Eddy simulations, LES, actuator disc, ACD, forced boundary layer, FBL, coriolis, wind veer
    National Category
    Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-379116 (URN)10.3390/app9050922 (DOI)000462504400109 ()
    Funder
    Swedish National Infrastructure for Computing (SNIC)
    Available from: 2019-03-12 Created: 2019-03-12 Last updated: 2019-04-25Bibliographically approved
    7. The Long distance wake behind Horns Rev I studied using large eddy simulations and a wind turbine parameterization in WRF
    Open this publication in new window or tab >>The Long distance wake behind Horns Rev I studied using large eddy simulations and a wind turbine parameterization in WRF
    Show others...
    2017 (English)In: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 854, article id 012012Article in journal (Refereed) Published
    Abstract [en]

    The aim of the present paper is to obtain a better understanding of long distance wakes generated by wind farms as a first step towards a better understanding of farm to farm interaction. The Horns Rev I (HR) wind farm is considered for this purpose, where comparisons are performed between microscale Large Eddy Simulations (LES) using an Actuator Disc model (ACD), mesoscale simulations in the Weather Research and Forecasting Model (WRF) using a wind turbine parameterization, production data as well as wind measurements in the wind farm wake. The LES is manually set up according to the wind conditions obtained from the mesoscale simulation as a first step towards a meso/microscale coupling.

    The LES using an ACD are performed in the EllipSys3D code. A forced boundary layer (FBL) approach is used to introduce the desired wind shear and the atmospheric turbulence field from the Mann model. The WRF uses a wind turbine parameterization based on momentum sink. To make comparisons with the LESs and the site data possible an idealized setup of WRF is used in this study.

    The case studied here considers a westerly wind direction sector (at hub height) of 270 ± 2.5 degrees and a wind speed of 8 ± 0.5 m/s. For both the simulations and the site data a neutral atmosphere is considered. The simulation results for the relative production as well as the wind speed 2 km and 6 km downstream from the wind farm are compared to site data. Further comparisons between LES and WRF are also performed regarding the wake recovery and expansion.

    The results are also compared to an earlier study of HR using LES as well as an earlier comparison of LES and WRF. Overall the results in this study show a better agreement between LES and WRF as well as better agreement between simulations and site data.

    The procedure of using the profile from WRF as inlet to LES can be seen as a simplified coupling of the models that could be developed further to combine the methods for cases of farm to farm interaction.

    National Category
    Meteorology and Atmospheric Sciences
    Identifiers
    urn:nbn:se:uu:diva-362564 (URN)10.1088/1742-6596/854/1/012012 (DOI)000435276400012 ()
    Conference
    Wake Conference 2017, 30 May to 1 June 2017, Visby, Sweden
    Available from: 2018-10-07 Created: 2018-10-07 Last updated: 2019-03-18Bibliographically approved
  • Public defence: 2019-05-17 10:15 Sal IV, Uppsala
    Yadala Suneson, Anita
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Church and Mission studies.
    Indian Protestants and their Religious Others: Views of Religious Diversity among Christians in Bangalore2019Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This study gives an in-depth insight into ways that ordinary Christians in a multireligious context think about religious plurality. It examines how Indian Protestants reflect upon other religions and upon the situation of religious diversity.

    Methodologically, the study relies mainly on qualitative interviews with Pentecostal and Church of South India (CSI) lay members and pastors from Bangalore, south India. The interviews are analysed through thematic analysis.

    The study reveals a theological diversity among interviewees. The major differences are found among the clergy, while the views of Pentecostal and CSI lay interviewees show many similarities. The dominant theological perspective is evangelical and this forms an “evangelical lens” that colours attitudes to other religions. Additionally, a general Protestant perspective emerges that reflects a typically Protestant emphasis on Christ and the Bible, as well as a liberal Protestant perspective which focuses on social issues.

    Salvation, primarily understood in terms of eternal life for the individual, is central to the ideas interviewees have about the difference between Protestant Christianity and other religions. Perceptions of Hinduism reveal stereotypical views which portray it as an antithesis to Christian faith. Views of Islam are more positive, and similarities with Protestantism are perceived. Attitudes to different Christian traditions, and to Catholicism in particular, illustrate that the line between religious self and other can be drawn also between different forms of Christianity.

    An important finding of the study is that the use of religious images is a central issue for these Protestant Christians which affects their views of other religions and that it signals religious otherness to them. The dichotomy between religious self and other refers primarily to salvation and religious efficacy, not to everyday life. As people, Muslims and particularly Hindus are portrayed in a positive light. Interreligious friendship and unstressful everyday interaction characterise interviewees’ depictions of relations with religious others in Bangalore. The religious minority status becomes plainly evident in relation to mission. Interviewees negotiate between an ideal of active evangelism and social considerations. This study reveals that it is possible to combine theological exclusivism in theory with respect for the religious other in practice.

  • Public defence: 2019-05-20 10:15 Humanistiska teatern, Uppsala
    Sundh, Joakim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    The Cognitive Basis of Joint Probability Judgments: Processes, Ecology, and Adaption2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    When navigating an uncertain world, it is often necessary to judge the probability of a conjunction of events, that is, their joint probability. The subject of this thesis is how people infer joint probabilities from probabilities of individual events. Study I explored such joint probability judgment tasks in conditions with independent events and conditions with systematic risk that could be inferred through feedback. Results indicated that participants tended to approach the tasks using additive combinations of the individual probabilities, but switch to multiplication (or, to a lesser extent, exemplar memory) when events were independent and additive strategies therefore were less accurate. Consequently, participants were initially more accurate in the task with high systematic risk, despite that task being more complex from the perspective of probability theory. Study II simulated the performance of models of joint probability judgment in tasks based both on computer generated data and real-world data-sets, to evaluate which cognitive processes are accurate in which ecological contexts. Models used in Study I and other models inspired by current research were explored. The results confirmed that, by virtue of their robustness, additive models are reasonable general purpose algorithms, although when one is familiar with the task it is preferable to switch to other strategies more specifically adapted to the task. After Study I found that people adapt strategy choice according to dependence between events and Study II confirmed that these adaptions are justified in terms of accuracy, Study III investigated whether adapting to stochastic dependence implied thinking according to stochastic principles. Results indicated that this was not the case, but that participants instead worked according to the weak assumption that events were independent, regardless of the actual state of the world. In conclusion, this thesis demonstrates that people generally do not combine individual probabilities into joint probability judgments in ways consistent with the basic principles of probability theory or think of the task in such terms, but neither does there appear to be much reason to do so. Rather, simpler heuristics can often approximate equally or more accurate judgments.

    List of papers
    1. Compound risk judgment in tasks with both idiosyncratic and systematic risk: The “Robust Beauty” of additive probability integration
    Open this publication in new window or tab >>Compound risk judgment in tasks with both idiosyncratic and systematic risk: The “Robust Beauty” of additive probability integration
    2018 (English)In: Cognition, ISSN 0010-0277, E-ISSN 1873-7838, Vol. 171, p. 25-41Article in journal (Refereed) Published
    Abstract [en]

    In this study, we explore how people integrate risks of assets in a simulated financial market into a judgment of the conjunctive risk that all assets decrease in value, both when assets are independent and when there is a systematic risk present affecting all assets. Simulations indicate that while mental calculation according to naïve application of probability theory is best when the assets are independent, additive or exemplar-based algorithms perform better when systematic risk is high. Considering that people tend to intuitively approach compound probability tasks using additive heuristics, we expected the participants to find it easiest to master tasks with high systematic risk – the most complex tasks from the standpoint of probability theory – while they should shift to probability theory or exemplar memory with independence between the assets. The results from 3 experiments confirm that participants shift between strategies depending on the task, starting off with the default of additive integration. In contrast to results in similar multiple cue judgment tasks, there is little evidence for use of exemplar memory. The additive heuristics also appear to be surprisingly context-sensitive, with limited generalization across formally very similar tasks.

    Keywords
    Multiple risk integration, Linear additive integration, Probability, Risk
    National Category
    Psychology (excluding Applied Psychology)
    Research subject
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-337841 (URN)10.1016/j.cognition.2017.10.023 (DOI)000427208300004 ()
    Funder
    Swedish Research Council
    Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2019-03-24Bibliographically approved
    2. The Ecological Scopes of Cognitive Models for Joint Probability Judgment
    Open this publication in new window or tab >>The Ecological Scopes of Cognitive Models for Joint Probability Judgment
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    A joint probability judgment is an estimation of the probability that a number of uncertain events will occur simultaneously. Many cognitive theories suggest processes by which the probability estimates of individual events are combined to form a joint probability judgment, often supported by behavioral experiments. However, representative selections of algorithms have rarely been compared side by side in order to evaluate their performance in a wide variety of ecological contexts, which could constitute an important insight into why and when people are likely to use different algorithms. To this end, five models informed by current research in joint probability judgment were applied to both computer generated and real-world data. The data were systematically varied regarding the number of events in a judgment, dependence between events, and precision in individual probability estimates. The models represented, respectively, (naïve) application of probability theory via multiplication, the representativeness heuristic, a variation on the take-the-best heuristic, weighted additive integration, and a general exemplar-based process. Application of the models to real-world data confirmed the conclusions from the computer generated data relative to real-world contexts. The results indicate that the weighted addition and exemplar-based models process information in a more efficient manner relative to the other models and perform accurately across a wide variety of contexts. It follows that weighted addition and/or exemplar-based models can represent “general-purpose” cognitive processes for joint probability judgment, in turn lending further credence to exemplar-based models as a mechanism for Bayesian inference.

    Keywords
    Joint probability, Ecological rationality, Computational modelling
    National Category
    Psychology
    Research subject
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-380097 (URN)
    Available from: 2019-03-24 Created: 2019-03-24 Last updated: 2019-03-24
    3. Appreciation for Independence: Does Adaptation to Stochastic Dependence Imply Thinking According to Stochastic Principles?
    Open this publication in new window or tab >>Appreciation for Independence: Does Adaptation to Stochastic Dependence Imply Thinking According to Stochastic Principles?
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Do people think of their environments in probabilistic concepts like “dependent” or “independent” events? Research has shown that people can learn from feedback to make accurate joint probability judgments in both cases, but it is unclear whether this implies an understanding of the task structure with respect to dependence. In this article, we report two experiments that investigate if accuracy in joint probability judgment tasks implies understanding the presence or absence of dependencies between the events in the task. Experiment 1 involved a symbolic task with stated numerical risks, whereas Experiment 2 compared this format with judgments from experience where the participants learned the joint probabilities from direct (binary) experience of the events occurring or not. The results demonstrate that participants rapidly learned to make accurate judgments of the joint probability both when events where dependent and independent, and computational modeling suggests that they draw on a variety of strategies ranging from analytic multiplication informed by probability theory, over heuristic weighted additive or weighted minimum models, to sampled proportions or exemplar memory. Despite successfully learning to accurately assess the joint probabilities, there were no indications that the participants successfully discovered whether the events were dependent or not. This suggests that rather than spontaneously thinking of the world in probabilistic terms, participants draw on generic cognitive resources with little or no conceptual overlap with notions of probability theory.

    Keywords
    Joint probability judgment, judgment from experience, task understanding
    National Category
    Psychology
    Research subject
    Psychology; Psychology
    Identifiers
    urn:nbn:se:uu:diva-380098 (URN)
    Available from: 2019-03-24 Created: 2019-03-24 Last updated: 2019-03-24
  • af Klercker, Oscar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    I gränslandet mellan brottsbalken kapitel 4 och 5.: Om olaga integritetsintrång och förtal i dess tillämpning på spridandet av hämndporr.2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Sedan internets och sociala mediers framväxt under de senaste dryga tjugo åren har regleringen om skyddet för den personliga integriteten ställts inför viktiga nya utmaningar. Särskilt gäller detta vid spridning av integritetskränkande uppgifter, något som till stor del underlättas av dagens teknologi. Begreppet personlig integritet har i lagstiftningssammanhang definierats som ”den sfär som omger alla människor och inom vilken han eller hon bör kunna vara fredad och där intrång bör kunna avvisas”, och särskilt integritetskränkande har generellt sett ingrepp som rör en persons sexuella förhållanden ansetts. Spridandet av bilder och filmer av sexuell natur där den porträtterades samtycke till spridandet saknas brukar benämnas hämndporr.

    Den svenska regleringen av spridandet av hämndporr har sedan avgörandet NJA 1992 s. 594 framför allt bedömts falla in under förtalsbestämmelsen i 5 kap. 1 § brottsbalken (BrB). Enligt bestämmelsen ska den uppgift som lämnats ha varit ägnad att utsätta den enskilde för andras missaktning. Att förtal regleras i brottsbalkens femte kapitel innebär att det utgör ett ärekränkningsbrott och att det intresse som bestämmelsen härmed har att skydda är en persons ära och heder. Det vill säga anseendet i förhållande till andra människor. I avgörandet hade en inspelad samlagsfilm spridits till ett antal personer och handlandet ansågs utsätta den porträtterade för dessas missaktning då uppfattningen kunde ges att denne inte haft något emot att filmen visades för andra. Denna praxisutveckling har å ena sidan ansetts behövlig för att undvika otillfredsställande resultat i rättstillämpningen där tydliga hål blottas i integritetsinskyddet men har också starkt kritiserats för att ha tillämpat förtalsbestämmelsen på ett oriktig och konstlat sätt. Trots otillfredsställda röster om ett bristfälligt integritetsskydd kan avgörandet ändå påstås ha bidragit till ett släckande av bränder på hämndporrens tidigare oreglerade område.

    Den 1 januari 2018 infördes den nya bestämmelsen olaga integritetsintrång i 4 kap. 6c § BrB. Bestämmelsens övergripande syfte är att skapa en tydlig och enhetlig kriminalisering av större spridningar av integritetskänsliga uppgifter och därigenom stärka skyddet för den personliga integriteten i detta avseende. I punktform radar den nya bestämmelsen upp vilka typer av uppgifter som den enskilde bör skyddas från att få spridda. I den inledande av dessa upptas uppgifter om annans sexualliv och i den femte uppgifter som rör någons nakna kropp och lagstiftaren tycks med dessa punkter haft en tydlig avsikt att komma åt de allvarliga integritetsintrång som spridande av hämndporr kan innebära. Brottsbalkens fjärde kapitel, där detta straffbud fått husera, bygger på ett skyddsintresse som riktar sig mer direkt mot olika typer av ingrepp i den personliga integriteten; frihet och frid.

    Bestämmelsen om förtal och olaga integritetsintrång är därmed båda ute efter handlingar där någon typ av nedsättande eller kränkande uppgifter om en annan person olovligen delats vidare till en eller flera utomstående parter. Bestämmelserna, som i stor utsträckning utformats på likande sätt, har tillämpningsområden som i hög grad överlappar varandra och bör enligt förarbetena som utgångspunkt kunna dömas i konkurrens. Bestämmelserna har dock fått ta plats i olika kapitel i brottsbalken. Kapitel som, trots att de kan sägas vara närbesläktade, har skilda skyddsintressen. I någon mån kan en bestämmelses skyddsintresse anses utgöra dess existensberättigande och dess tolkning och tillämpning bör därför i någon mån alltid kunna härledas till detta.

    Det är med denna utveckling i ryggen som denna framställning ger sig ut för att granska vår svenska reglering kring spridandet av hämndporr och dess balansgång mellan brottsbalkens fjärde och femte kapitel.

  • Elmstedt, Sixten
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Mogensen, Hanna
    Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
    Hallmans, Dan-Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Tavelin, Björn
    Umea Univ, Dept Radiat Sci, Umea, Sweden.
    Lundström, Staffan
    Karolinska Inst, Stockholms Sjukhem Fdn, Stockholm, Sweden;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
    Lindskog, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Cancer patients hospitalised in the last week of life risk insufficient care quality - a population-based study from the Swedish Register of Palliative Care2019In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 58, no 4, p. 432-438Article in journal (Refereed)
    Abstract [en]

    Background: One-quarter of all cancer deaths in Sweden occur in hospitals. If the place of death affects the quality of end-of-life (EOL) is largely unknown.

    Methods: This population-based, retrospective study included all adults cancer deaths reported to the Swedish Register of Palliative Care in 2011-2013 (N = 41,729). Hospital deaths were compared to deaths occurring in general or specialised palliative care, or in nursing homes with respect to care quality indicators in the last week of life. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with specialised palliative home care as reference.

    Results: Preferred place of death was unknown for 63% of hospitalised patients and consistent with the actual place of death in 25% compared to 97% in palliative home care. Hospitalised patients were less likely to be informed when death was imminent (OR: 0.3; CI: 0.28-0.33) as were their families (OR: 0.51; CI: 0.46-0.57). Validated screening tools were less often used in hospitals for assessment of pain (OR: 0.32; CI: 0.30-0.34) or other symptoms (OR: 0.31; CI: 0.28-0.34) despite similar levels of EOL symptoms. Prescriptions of as needed drugs against anxiety (OR: 0.27; CI: 0.24-0.30), nausea (OR: 0.19; CI: 0.17-0.21), or pulmonary secretions (OR: 0.29; CI: 0.26-0.32) were less prevalent in hospitals. Bereavement support was offered after 57% of hospital deaths compared to 87-97% in palliative care units and 72% in nursing homes.

    Conclusions: Dying in hospital was associated with inferior end-of-life care quality among cancer patients in Sweden.

  • Zhu, Yanping
    et al.
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Qi, Xiaoying
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Yu, Cuicui
    Qing Dao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Anesthesiol, 20 Yudong Rd, Yantai S264009, Shandong, Peoples R China.
    Yu, Shoujun
    Binzhou Med Univ, Yantai Affiliated Hosp, Dept Ultrasound, 717 Jinfu Rd, Binzhou 264100, Shandong, Peoples R China.
    Zhang, Chao
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Zhang, Yuan
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Liu, Xiuxiu
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Xu, Yuxue
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Yang, Chunhua
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Jiang, Wenguo
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Tian, Geng
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Li, Xuri
    Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China.
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Zhang, Jiandi
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China;Yantai Zestern Biotech Co LTD, 39 Keji Ave Bioasis, Yantai, Peoples R China.
    Wang, Lei
    Harbin Med Univ, Affiliated Hosp 1, Dept Thorac Surg, 23 Youzheng St, Harbin 150000, Heilongjiang, Peoples R China.
    Mi, Jia
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)2019In: Clinical Proteomics, ISSN 1542-6416, E-ISSN 1559-0275, Vol. 16, article id 12Article in journal (Refereed)
    Abstract [en]

    Background: Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

    Methods: In this study, we compared the protein expression profiles in esophageal squamous cell carcinoma (ESCC) tissues and adjacent normal esophageal tissues from five patients through high-resolution label-free mass spectrometry. Through bioinformatics analysis, we found the differentially expressed proteins of ESCC. To perform the rapid identification of biomarkers, we adopted a high-throughput protein identification technique of Quantitative Dot Blot (QDB). Meanwhile, the QDB results were verified by classical immunohistochemistry.

    Results: In total 2297 proteins were identified, out of which 308 proteins were differentially expressed between ESCC tissues and normal tissues. By bioinformatics analysis, the four up-regulated proteins (PTMA, PAK2, PPP1CA, HMGB2) and the five down-regulated proteins (Caveolin, Integrin beta-1, Collagen alpha-2(VI), Leiomodin-1 and Vinculin) were selected and validated in ESCC by Western Blot. Furthermore, we performed the QDB and IHC analysis in 64 patients and 117 patients, respectively. The PTMA expression was up-regulated gradually along the progression of ESCC, and the PTMA expression ratio between tumor and adjacent normal tissue was significantly increased along with the progression. Therefore, we suggest that PTMA might be a potential candidate biomarker for ESCC.

    Conclusion: In this study, label-free quantitative proteomics combined with QDB revealed that PTMA expression was up-regulated in ESCC tissues, and PTMA might be a potential candidate for ESCC. Since Western Blot cannot achieve rapid and high-throughput screening of mass spectrometry results, the emergence of QDB meets this demand and provides an effective method for the identification of biomarkers.

  • Persson Nääf, Jennifer
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Substantive Representation seen through the Instersectional Lens of Gender & Ethnicity: A case study on how a women from a minority navigates her presidential campaign within the context of the Mexican Election 20182018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Wang, Kun
    et al.
    Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, Svante Arrhenius V 20C, SE-10691 Stockholm, Sweden.
    Sybers, David
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Maklad, Hassan Ramadan
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Lemmens, Liesbeth
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Lewyllie, Charlotte
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium;Vrije Univ Brussel, Dept Biol, Lab Cell Genet, Pl Laan 2, B-1050 Brussels, Belgium.
    Zhou, Xiaoxiao
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Schult, Frank
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Bräsen, Christopher
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Siebers, Bettina
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Valegård, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.
    Lindås, Ann-Christin
    Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, Svante Arrhenius V 20C, SE-10691 Stockholm, Sweden.
    Peeters, Eveline
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 1542Article in journal (Refereed)
    Abstract [en]

    Fatty acid metabolism and its regulation are known to play important roles in bacteria and eukaryotes. By contrast, although certain archaea appear to metabolize fatty acids, the regulation of the underlying pathways in these organisms remains unclear. Here, we show that a TetR-family transcriptional regulator (FadR(sa)) is involved in regulation of fatty acid metabolism in the crenarchaeon Sulfolobus acidocaldarius. Functional and structural analyses show that FadR(sa) binds to DNA at semi-palindromic recognition sites in two distinct stoichiometric binding modes depending on the operator sequence. Genome-wide transcriptomic and chromatin immunoprecipitation analyses demonstrate that the protein binds to only four genomic sites, acting as a repressor of a 30-kb gene cluster comprising 23 open reading frames encoding lipases and beta-oxidation enzymes. Fatty acyl-CoA molecules cause dissociation of FadR(sa) binding by inducing conformational changes in the protein. Our results indicate that, despite its similarity in overall structure to bacterial TetR-family FadR regulators, FadR(sa) displays a different acyl-CoA binding mode and a distinct regulatory mechanism.

  • Tresse, Anja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The Impact of Female Political Leaders on Attitudes towards Gender Equality and Violence: - Survey evidence from Kerala, India2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Studies have repeatedly reported that states with higher levels of gender equality are more peaceful. Similarly, research has shown that individuals who hold feminist attitudes also hold more peaceful attitudes. This paper argues that there is a lack of studies on the relationship between gender equality and peaceful attitudes on the individual level. Building upon studies suggesting that gender equality is key in working towards peace, this paper investigates whether female political leaders can affect attitudes to gender equality and to violence. By integrating experimental components in a comparative case study, this study gathered survey-evidence from two villages in Kerala, India. The findings suggest that continuous exposure to female political leaders lead to more approving attitudes of gender equality but does not find enough support suggesting that attitudes towards violence are affected.

  • Jespers, Willem
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Esguerra, Mauricio
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Åqvist, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Gutiérrez-de-Terán, Hugo
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    QligFEP: an automated workflow for small molecule free energy calculations in Q2019In: Journal of Cheminformatics, ISSN 1758-2946, E-ISSN 1758-2946, Vol. 11, article id 26Article in journal (Refereed)
    Abstract [en]

    The process of ligand binding to a biological target can be represented as the equilibrium between the relevant solvated and bound states of the ligand. This which is the basis of structure-based, rigorous methods such as the estimation of relative binding affinities by free energy perturbation (FEP). Despite the growing capacity of computing power and the development of more accurate force fields, a high throughput application of FEP is currently hampered due to the need, in the current schemes, of an expert user definition of the alchemical transformations between molecules in the series explored. Here, we present QligFEP, a solution to this problem using an automated workflow for FEP calculations based on a dual topology approach. In this scheme, the starting poses of each of the two ligands, for which the relative affinity is to be calculated, are explicitly present in the MD simulations associated with the (dual topology) FEP transformation, making the perturbation pathway between the two ligands univocal. We show that this generalized method can be applied to accurately estimate solvation free energies for amino acid sidechain mimics, as well as the binding affinity shifts due to the chemical changes typical of lead optimization processes. This is illustrated in a number of protein systems extracted from other FEP studies in the literature: inhibitors of CDK2 kinase and a series of A(2A) adenosine G protein-coupled receptor antagonists, where the results obtained with QligFEP are in excellent agreement with experimental data. In addition, our protocol allows for scaffold hopping perturbations to identify the binding affinities between different core scaffolds, which we illustrate with a series of Chk1 kinase inhibitors. QligFEP is implemented in the open-source MD package Q, and works with the most common family of force fields: OPLS, CHARMM and AMBER.

  • Skan, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Reconstructing ICMEs with the toroidal Grad-Shafranov method2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The main objective of this thesis is to model the magneticstructure of interplanetary coronal mass ejections (ICME) measuredin-situ from the WIND spacecraft positioned at L1. The modeling isdone by a magnetohydrodynamic reconstruction technique based onthe GS equation with a toroidal geometry. The purpose has been toextend the application of the reconstruction program to real dataand to test its performance when different input parameters arechanged. Two events are presented; 16-17 May 2012 and 15-16 May2005 ICMEs have been successfully reconstructed with this model.

    The main achievements of the study are that a) the code now worksfor real data b) the important parameters that can be changed fordifferent reconstructions in the code are the number of iterationsused to find the optimal Z-axis, the plasma pressure and the orderof the polynomial fitting of the flux functional, c) if all crosssection reconstructions for different variations of theseparameters strongly resembles each other then this is anindication that the model approximation is good and that the fluxrope exists. The results have been compared and verified withpreviously published studies of these events.

    Using a toroidal geometry for the GS reconstruction method weobtain very similar results to the one obtained with differentreconstruction techniques.This implies that at L1, the ICMEs haveexpanded so much that a cylindrical geometry is sufficient todescribe the flux rope geometry. The toroidal Grad-Shafranovreconstruction technique is best suited for circular, or slightlyelongated, flux rope cross section profiles but have been provento work for one complex ejecta consisting of two merged fluxropes. The toroidal model might become an important asset in thefuture when data from spacecraft closer to the Sun, such as ParkerSolar Probe and Solar Orbiter, is public. When the major radius ofthe flux rope is smaller the choice of geometry will most likelyhave a larger role than for measurements at L1 and so, thetoroidal Grad-Shafranov reconstruction technique will probably bethe better alternative of the models that exists today.

  • Segerström, Niklas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction.
    Utvärdering av VR-manövrering av en brandrobot2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis evaluates the suitability of using a VR-interface to help maneuver a teleoperated robot designed to assist firefighters. Head mounted displays together with teleoperated robots are becoming more popular but the question is if the technology can be adapted to fit the needs and requirements of the firefighters. The technology will be used in high-stress situations without a big margin for error. Focus group interviews and user tests together with an analysis of current research have been performed to try and give an answer on how suitable VR-interfaces are.

    To efficiently implement a VR-interface the developers of the robot need to have a clear user profile. The designers need to use the expert knowledge of the firefighters for best results. The implementation will overall have a positive effect on the users situational awareness and the robot will become easier to maneuver, given that the developers use hardware compatible to the needs of VRglasses.

  • Buder, S.
    et al.
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany;Heidelberg Univ, Int Max Planck Res Sch Astron & Cosm Phys, Heidelberg, Germany.
    Lind, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy. MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Ness, M. K.
    Columbia Univ, Dept Astron, Pupin Phys Labs, New York, NY 10027 USA;Flatiron Inst, Ctr Computat Astrophys, 162 Fifth Ave, New York, NY 10010 USA.
    Asplund, M.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia;Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia.
    Duong, L.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Lin, J.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Kos, J.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Casagrande, L.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Casey, A. R.
    Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia;Monash Univ, Fac Informat Technol, Melbourne, Vic, Australia.
    Bland-Hawthorn, J.
    Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia;Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ Calif Berkeley, Miller Inst, Berkeley, CA 94720 USA.
    De Silva, G. M.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia.
    D'Orazi, V
    Osserv Astron Padova, Ist Nazl Astrofis, Vicolo Osservatorio 5, I-35122 Padua, Italy.
    Freeman, K. C.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Martell, S. L.
    Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia;Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia.
    Schlesinger, K. J.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Sharma, S.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Simpson, J. D.
    Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia.
    Zucker, D. B.
    Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia.
    Zwitter, T.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Cotar, K.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Dotter, A.
    Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA.
    Hayden, M. R.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Hyde, E. A.
    Western Sydney Univ, Locked Bag 1797, Penrith, NSW 2751, Australia.
    Kafle, P. R.
    Univ Western Australia, ICRAR, 35 Stirling Highway, Crawley, WA 6009, Australia.
    Lewis, G. F.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Nataf, D. M.
    Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA.
    Nordlander, T.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia;Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia.
    Reid, W.
    Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia;Western Sydney Univ, Locked Bag 1797, Penrith, NSW 2751, Australia.
    Rix, H-W
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Skuladottir, A.
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Stello, D.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia;Aarhus Univ, Stellar Astrophys Ctr, Dept Phys & Astron, DK-8000 Aarhus C, Denmark.
    Ting, Y-S
    Inst Adv Study, Olden Lane, Princeton, NJ 08540 USA;Princeton Univ, Dept Astrophys Sci, Princeton, NJ 08544 USA;Observ Carnegie Inst Washington, 813 Santa Barbara St, Pasadena, CA 91101 USA.
    Traven, G.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Wyse, R. F. G.
    Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA.
    The GALAH survey: An abundance, age, and kinematic inventory of the solar neighbourhood made with TGAS2019In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 624, article id A19Article in journal (Refereed)
    Abstract [en]

    The overlap between the spectroscopic Galactic Archaeology with HERMES (GALAH) survey and Gaia provides a high-dimensional chemodynamical space of unprecedented size. We present a first analysis of a subset of this overlap, of 7066 dwarf, turn-off, and subgiant stars. These stars have spectra from the GALAH survey and high parallax precision from the Gaia DR1 Tycho-Gaia Astrometric Solution. We investigate correlations between chemical compositions, ages, and kinematics for this sample. Stellar parameters and elemental abundances are derived from the GALAH spectra with the spectral synthesis code SPECTROSCOPY MADE EASY. We determine kinematics and dynamics, including action angles, from the Gaia astrometry and GALAH radial velocities. Stellar masses and ages are determined with Bayesian isochrone matching, using our derived stellar parameters and absolute magnitudes. We report measurements of Li, C, O, Na, Mg, Al, Si, K, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Y, as well as Ba and we note that we have employed non-LTE calculations for Li, O, Al, and Fe. We show that the use of astrometric and photometric data improves the accuracy of the derived spectroscopic parameters, especially log g. Focusing our investigation on the correlations between stellar age, iron abundance [Fe/H], and mean alpha-enhancement [alpha/Fe] of the magnitude-selected sample, we recover the result that stars of the high-a sequence are typically older than stars in the low-a sequence, the latter spanning iron abundances of -0.7 < [Fe/H] < +0.5. While these two sequences become indistinguishable in [alpha/Fe] vs. [Fe/H] at the metal-rich regime, we find that age can be used to separate stars from the extended high-a and the low-a sequence even in this regime. When dissecting the sample by stellar age, we find that the old stars (>8 Gyr) have lower angular momenta L-z than the Sun, which implies that they are on eccentric orbits and originate from the inner disc. Contrary to some previous smaller scale studies we find a continuous evolution in the high-alpha-sequence up to super-solar [Fe/H] rather than a gap, which has been interpreted as a separate "high-alpha metal-rich" population. Stars in our sample that are younger than 10 Gyr, are mainly found on the low alpha-sequence and show a gradient in L-z from low [Fe/H] > (L-z > L-z,L-circle dot) towards higher [Fe/H] (L-z < L-z,L-circle dot), which implies that the stars at the ends of this sequence are likely not originating from the close solar vicinity.

  • Lundquist, Josefine
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Bergström, Sandra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    “Lika med det visar rätta svaret och man kan använda det för att göra en emojig”: En undersökning om hur elever i årskurs 3 och 6 uppfattar likhetstecknet.2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna uppsats är att undersöka de praktiska implikationerna som den senaste läroplanen Lgr11 har inneburit för förståelsen av algebra hos elever i början och mitten av grundskolan. Arbetets metoden och analysen är ett test som kan ses som en enkätundersökning som delades ut till elever i årskurs 3 och 6. Materialet samlades in under två dagar på en medelstor skola i en svensk storstad. Utifrån tidigare forskning och teorier har elevernas kunskapsnivå analyserats och kategoriserats. Det är i huvudsak ett antal utvalda testfrågor som analyserats och det är genomgående deskriptiva statistiska mått vi använt oss av. Resultaten visar att eleverna i dessa årskurser har en relativt sett god förståelse för likhetstecknet och algebra. Däremot visar resultaten vissa luckor hos eleverna som också ligger i linje med internationella studier av samma slag. Undersökningen kan visa att algebrakunskaperna befinner sig i en positiv trend men att potentiella luckor i läroplanen innebära att elever får bristande kunskaper i generaliserad aritmetik, en viktig del i förståelsen av algebra.

  • Porter, Amy
    et al.
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Eckardt, Winnie
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Vecellio, Veronica
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Guschanski, Katerina
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Niehoff, Peter Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Ngobobo-As-Ibungu, Urbain
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Pekeyake, Radar Nishuli
    Inst Congolais Conservat Nat, Kinshasa, DEM REP CONGO.
    Stoinski, Tara
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Caillaud, Damien
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA;Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA.
    Behavioral responses around conspecific corpses in adult eastern gorillas (Gorilla beringei spp.)2019In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 7, article id e6655Article in journal (Refereed)
    Abstract [en]

    Humans were once considered unique in having a concept of death but a growing number of observations of animal responses to dying and dead conspecifics suggests otherwise. Complex arrays of behaviors have been described ranging from corpse removal and burial among social insects to quiet attendance and caregiving among elephants and primates. Less frequently described, however, are behavioral responses of individuals from different age/sex classes or social position toward the death of conspecifics. We describe behavioral responses of mountain gorillas (Gorilla beringei beringei) to the deaths of a dominant silverback and a dominant adult female from the same social group in Volcanoes National Park in Rwanda and the responses of Grauer's gorillas (Gorilla b. graueri) to the corpse of an extra-group silverback in Kahuzi-Biega National Park, Democratic Republic of Congo. In gorillas, interactions between groups or with a lone silverback often result in avoidance or aggression. We predicted that: (i) more individuals should interact with the corpses of same-group members than with the corpse of the extra-group silverback; (ii) adult females with infants should avoid the corpse of the extra-group silverback; and (iii) in the mountain gorilla cases, individuals that shared close social relationships with the dead individual should spend more time with the corpse than other individuals in the group. We used a combination of detailed qualitative reports, photos, and videos to describe all occurrences of affiliative/investigative and agonistic behaviors observed at the corpses. We observed similar responses toward the corpses of group and extra-group individuals. Animals in all three cases showed a variety of affiliative/investigative and agonistic behaviors directed to the corpses. Animals of all age/sex classes interacted with the corpses in affiliative/investigative ways but there was a notable absence of all adult females at the corpse of the extra-group silverback. In all three cases, we observed only silverbacks and blackbacks being agonistic around and/or toward the corpses. In the mountain gorilla cases, the individuals who spent the most time with the corpses were animals who shared close social relationships with the deceased. We emphasize the similarity in the behavioral responses around the corpses of group and extra-group individuals, and suggest that the behavioral responses were influenced in part by close social relationships between the deceased and certain group members and by a general curiosity about death. We further discuss the implications close interactions with corpses have for disease transmission within and between gorilla social groups.

  • Liu, Ruishan
    et al.
    Stanford Univ, Dept Elect Engn, 450 Serra Mall, Stanford, CA 94305 USA.
    Mignardi, Marco
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction. Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA;Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Jones, Robert
    Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA.
    Enge, Martin
    Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA.
    Kim, Seung K.
    Stanford Univ, Dept Dev Biol, 279 Campus Dr, Stanford, CA 94305 USA.
    Quake, Stephen R.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology. Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Zou, James
    Stanford Univ, Dept Biomed Data Sci, 450 Serra Mall, Stanford, CA 94305 USA;Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 5592Article in journal (Refereed)
    Abstract [en]

    Recently high-throughput image-based transcriptomic methods were developed and enabled researchers to spatially resolve gene expression variation at the molecular level for the first time. In this work, we develop a general analysis tool to quantitatively study the spatial correlations of gene expression in fixed tissue sections. As an illustration, we analyze the spatial distribution of single mRNA molecules measured by in situ sequencing on human fetal pancreas at three developmental time points-80, 87 and 117 days post-fertilization. We develop a density profile-based method to capture the spatial relationship between gene expression and other morphological features of the tissue sample such as position of nuclei and endocrine cells of the pancreas. In addition, we build a statistical model to characterize correlations in the spatial distribution of the expression level among different genes. This model enables us to infer the inhibitory and clustering effects throughout different time points. Our analysis framework is applicable to a wide variety of spatially-resolved transcriptomic data to derive biological insights.

  • Juhas, Mario
    et al.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Widlake, Emma
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Teo, Jeanette
    Natl Univ Singapore Hosp, Dept Lab Med, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
    Huseby, Douglas L
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Tyrrell, Jonathan M.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Polikanov, Yury S.
    Univ Illinois, Coll Liberal Arts & Sci, Dept Biol Sci, 900 South Ashland Ave,MBRB 4170, Chicago, IL 60607 USA.
    Ercan, Onur
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Petersson, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Cao, Sha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Aboklaish, Ali F.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Rominski, Anna
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Crich, David
    Wayne State Univ, Dept Chem, 5101 Cass Ave, Detroit, MI 48202 USA.
    Bottger, Erik C.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Walsh, Timothy R.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Hughes, Diarmaid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Hobbie, Sven N.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii2019In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 74, no 4, p. 944-952Article in journal (Refereed)
    Abstract [en]

    Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants.

    Methods: A thorough antibacterial assessment of apramycin with 1232 clinical isolates from Europe, Asia, Africa and South America was performed by standard CLSI broth microdilution testing. WGS and susceptibility testing with an engineered panel of aminoglycoside resistance-conferring determinants were used to provide a mechanistic rationale for the breadth of apramycin activity.

    Results: MIC distributions and MIC90 values demonstrated broad antibacterial activity of apramycin against Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Morganella morganii, Citrobacter freundii, Providencia spp., Proteus mirabilis, Serratia marcescens and A. baumannii. Genotypic analysis revealed the variety of aminoglycoside-modifying enzymes and rRNA methyltransferases that rendered a remarkable proportion of clinical isolates resistant to standard-of-care aminoglycosides, but not to apramycin. Screening a panel of engineered strains each with a single well-defined resistance mechanism further demonstrated a lack of cross-resistance to gentamicin, amikacin, tobramycin and plazomicin.

    Conclusions: Its superior breadth of activity renders apramycin a promising drug candidate for the treatment of systemic Gram-negative infections that are resistant to treatment with other aminoglycoside antibiotics.

  • Public defence: 2019-05-17 10:15 Humanistiska teatern, Uppsala
    Frick, Matilda A
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University.
    Self-Regulation in Childhood: Developmental Mechanisms and Relations to ADHD Symptoms2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Self-regulation is a multi-faceted construct that concerns goal-directed behaviors, which aid individuals in everyday life and in achieving long-term goals. Self-regulation in believed to progress in a hierarchical fashion, in that simple cognitive functions are integrated into more complex functions across development. Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous childhood-onset disorder, characterized by deficits in various aspects of self-regulation, including core symptoms of inattention and hyperactivity/impulsivity, and comorbidity with externalizing disorders such as oppositional defiant disorder (ODD). The last decade has seen a shift from simple etiological models towards more complex ones, which stress multiple pathways to the disorder. In addition, there is an ongoing search for early markers of the condition, which will increase our understanding, enable early detection, intervention, and perhaps even prevention of the full disorder. Cognitive regulation, aspects of temperament (i.e. negative affect, surgency, and effortful control), and parenting are three areas of importance for self-regulation in general and of ADHD symptoms in particular. Grounded in these three constructs, informed by the hierarchical model of self-regulation development, and a multiple pathway perspective on ADHD, the present thesis aimed to map development of self-regulation, with a special focus on inattention and hyperactivity/impulsivity. Four studies were conducted based on three samples, ranging from infancy to 12 years, including both typically developing children and children diagnosed with ADHD. Study I found that early sustained attention predicted later cognitive regulation, providing support for the hierarchical model of self-regulation development. In addition, maternal sensitivity contributed to higher levels of emotion regulation whereas surgency contributed to lower levels of emotion regulation. Study II gained support for a multiple pathway perspective on ADHD, in that higher temperamental regulation and maternal sensitivity contributed to lower levels of inattention and hyperactivity/impulsivity, and higher surgency contributed to higher levels of hyperactivity/impulsivity. Study III replicated findings from Study II and confirmed early temperament markers of later inattention and hyperactivity/impulsivity, and that early cognitive regulation was a poor predictor of later symptoms. Study IV proposed contributions of multiple regulatory functions to ADHD symptoms and elevated negative affect in ODD. The latter was moderated by parental support, which seemed to be a protective factor for children with high levels of negative affect. In all, the findings point to the importance of both intrinsic and extrinsic factors in the development of self-regulation, which seems to progress in a hierarchical fashion. Aspects of temperament rather than cognitive regulation seem to be valid early markers of later inattention and hyperactivity/impulsivity. Multiple pathways to ADHD symptoms are proposed, with contributions of maternal sensitivity and temperament early in development and different regulatory functions in school-aged children. In addition, elevated negative affect in combination with low parental support seem to be characteristic of ODD rather than of core symptoms of ADHD. The thesis contributes to the complexity and heterogeneity of ADHD and that ADHD is best viewed as a developmental disorder, in that the influence of various regulatory factors change over time.

    List of papers
    1. The role of sustained attention, maternal sensitivity, and infant temperament in the development of early self-regulation
    Open this publication in new window or tab >>The role of sustained attention, maternal sensitivity, and infant temperament in the development of early self-regulation
    Show others...
    2018 (English)In: British Journal of Psychology, ISSN 0007-1269, E-ISSN 2044-8295, Vol. 109, no 2, p. 277-298Article in journal (Refereed) Published
    Abstract [en]

    This study investigated infant predictors of early cognitive and emotional self-regulation from an intrinsic and caregiving environmental perspective. Sustained attention, reactive aspects of infant temperament, and maternal sensitivity were assessed at 10months (n=124) and early self-regulation (including executive functions, EF, and emotion regulation) was assessed at 18months. The results indicated that sustained attention predicted early EF, which provide empirical support for the hierarchical framework of EF development, advocating early attention as a foundation for the development of cognitive self-regulation. Maternal sensitivity and surgency predicted emotion regulation, in that infants of sensitive mothers showed more regulatory behaviours and a longer latency to distress, whereas high levels of surgency predicted low emotion regulation, suggesting both the caregiving environment and temperament as important in the development of self-regulation. Interaction effects suggested high sustained attention to be a protective factor for children of insensitive mothers, in relation to emotion regulation. In addition, high levels of maternal sensitivity seemed to foster development of emotion regulation among children with low to medium levels of sustained attention and/or surgency. In all, our findings point to the importance of both intrinsic and extrinsic factors in infant development of self-regulation.

    Place, publisher, year, edition, pages
    WILEY, 2018
    Keywords
    emotion regulation, executive functions, infant temperament, maternal sensitivity, self-regulation, sustained attention
    National Category
    Psychology (excluding Applied Psychology)
    Identifiers
    urn:nbn:se:uu:diva-352572 (URN)10.1111/bjop.12266 (DOI)000429702400007 ()28895129 (PubMedID)
    Funder
    Swedish Research Council, 421-2012-1222
    Available from: 2018-08-07 Created: 2018-08-07 Last updated: 2019-03-26Bibliographically approved
    2. Can reactivity and regulation in infancy predict inattentive and hyperactive/impulsive behavior in 3-year-olds?
    Open this publication in new window or tab >>Can reactivity and regulation in infancy predict inattentive and hyperactive/impulsive behavior in 3-year-olds?
    2018 (English)In: Development and psychopathology (Print), ISSN 0954-5794, E-ISSN 1469-2198Article in journal (Refereed) Epub ahead of print
    Abstract [en]

    A need to identify early infant markers of later occurring inattentive and hyperactive/impulsive behaviors has come to the fore in the current attention-deficit/hyperactivity disorder literature. The purpose of such studies is to identify driving mechanisms that could enable early detection of attention-deficit/hyperactivity disorder liability and thus facilitate early intervention. Here we study independent and interactive effects of cognitive regulation (inhibition and sustained attention), temperament (reactive and regulatory aspects), and maternal sensitivity (as external regulation) in a sample of 112 typically developing 10-month-old infants (59 boys, 52.7%), in relation to inattentive and hyperactive/impulsive behavior at 3 years. The results showed that infant temperamental regulation and maternal sensitivity made independent contributions to both inattention and hyperactivity/impulsivity, in that higher levels of temperamental regulation and maternal sensitivity were related to less inattentive and hyperactive/impulsive behavior. In addition, the temperamental factor positive affectivity/surgency made a significant contribution to later hyperactivity/impulsivity, in that higher levels of positive affectivity/surgency were related to more hyperactive/impulsive behavior. No interaction effects were found. Our findings suggest temperament and parental regulation as potential and independent markers of later inattentive and hyperactive/impulsive behavior.

    Place, publisher, year, edition, pages
    Cambridge University Press, 2018
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-348127 (URN)10.1017/S0954579418000160 (DOI)
    Funder
    Swedish Research Council, 421-2012-1222
    Available from: 2018-04-10 Created: 2018-04-10 Last updated: 2019-03-26Bibliographically approved
    3. Temperament and Cognitive Regulation During the First 3 Years of Life as Predictors of Inattention and Hyperactivity/Impulsivity at 6 Years.
    Open this publication in new window or tab >>Temperament and Cognitive Regulation During the First 3 Years of Life as Predictors of Inattention and Hyperactivity/Impulsivity at 6 Years.
    2018 (English)In: Journal of Attention Disorders, ISSN 1087-0547, E-ISSN 1557-1246, article id 1087054718804342Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVE: With a wish to identify early markers of inattention and hyperactivity/impulsivity, we examined effects of temperament and cognitive regulation, during the first 3 years of life, on later inattentive and hyperactive/impulsive behavior.

    METHOD: Temperament and cognitive regulation were assessed at 12, 18, 24, and 36 months in 66 typically developing children. Teachers rated inattention and hyperactivity/impulsivity at 6 years.

    RESULTS: Temperamental activity at all studied time points was predictive of later hyperactive/impulsive behavior, thus appearing as a stable marker thereof. Activity at 12 months was also predictive of inattention, whereas temperamental persistence was correlated with inattention and hyperactivity/impulsivity, but with no independent contributions. No significant relations between cognitive regulation and the outcome measures were found.

    CONCLUSION: Our findings add to the scarce literature proposing that markers of inattentive and hyperactive/impulsive behavior in early school age can be found within the first years of life, using parental ratings of child temperament.

    Place, publisher, year, edition, pages
    Sage Publications, 2018
    Keywords
    cognitive regulation, early markers, hyperactivity/impulsivity, inattention, temperament
    National Category
    Applied Psychology
    Identifiers
    urn:nbn:se:uu:diva-367226 (URN)10.1177/1087054718804342 (DOI)30296881 (PubMedID)
    Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2019-03-26Bibliographically approved
    4. A Multi-Factorial Perspecitve on ADHD and ODD in School-Aged Children: What is the Role of Cognitive Regulation, Temperament, and Parental Support?
    Open this publication in new window or tab >>A Multi-Factorial Perspecitve on ADHD and ODD in School-Aged Children: What is the Role of Cognitive Regulation, Temperament, and Parental Support?
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Introduction: It is well established that attention-deficit/hyperactivity disorder (ADHD) is a disorder of self-regulation. As such, ADHD is associated with disturbed cognitive regulation, extreme temperament traits, and deficient extrinsic regulation such as parenting. Despite these associations, cognitive regulation, temperament, and parenting have not previously been examined simultaneously in relation to ADHD symptoms in school-aged children. To bridge this gap of knowledge, we examined effects of these important aspects of self-regulation on symptoms of inattention, hyperactivity/impulsivity, and comorbid symptoms of oppositional defiant disorder (ODD) in children with and without a diagnosis of ADHD. Method: The sample consisted of 77 children aged 8-12 years (~40% had a diagnosis of ADHD). Cognitive regulation (i.e. complex inhibition and working memory) was assessed during a lab visit and parental ratings were used for measures of temperament (negative affect, surgency, and effortful control) and parental support. Parents and teachers rated ADHD and ODD symptoms in the child. Informed by a dimensional perspective on ADHD, continuous analyses were performed. Results: Working memory contributed independently to inattention (β = -.19, p < .05). Effortful control contributed independently to inattention and hyperactivity/impulsivity (βs = -.50 and -.49, ps < .01). Negative affect contributed to ODD as moderated by parental support (β = .58, p < .01). Specifically, for children who received lower levels of parental support there was a significant positive association between negative affect and ODD symptoms. Conclusions: The results propose that both cognitive regulation and effortful control influence ADHD symptoms. Moreover, different factors seem to be involved in ADHD and ODD, with regulatory deficits specifically related to ADHD symptoms, and elevated negative affect specifically related to ODD symptoms. Interestingly, parenting moderated the relationship between negative affect and ODD symptoms, with a suggested protective effect of high parental support for children with high levels of negative affect.

    Keywords
    ADHD, ODD, executive functions, temperament, parenting
    National Category
    Psychology
    Research subject
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-380103 (URN)
    Funder
    Sven Jerring Foundation, 2017/29
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26
  • Westerlund, Kristina
    et al.
    KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Dept Prot Sci, S-10691 Stockholm, Sweden.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Karlström, Amelie Eriksson
    KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Dept Prot Sci, S-10691 Stockholm, Sweden.
    Altai, Mohamed
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting2019In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 203, p. 73-85Article in journal (Refereed)
    Abstract [en]

    Pretargeting is a promising strategy to reach high imaging contrast in a shorter time than by targeting with directly radiolabeled monoclonal antibodies (mAbs). One of problems in pretargeting is a site-specific, reproducible and uniform conjugation of recognition tags to mAbs. To solve this issue we propose a photoconjugation to covalently couple a recognition tag to a mAb via a photoactivatable Z domain. The Z-domain, a 58-amino acid protein derived from the IgG-binding B-domain of Staphylococcus aureus protein A, has a well-characterized binding site in the Fc portion of IgG. We tested the feasibility of this approach using pretargeting based on hybridization between peptide nucleic acids (PNAs). We have used photoconjugation to couple trastuzumab with the PNA-based hybridization probe, HP1. A complementary [Co-57]Co-labeled PNA hybridization probe ([Co-57]Co-HP2) was used as the secondary targeting probe. In vitro studies demonstrated that trastuzumab-ZHP1 bound specifically to human epidermal growth factor receptor 2 (HER2)-expressing cells with nanomolar affinity. The binding of the secondary [Co-57]Co-HP2 probe to trastuzumab-PNA-pretreated cells was in the picomolar affinity range. A two-fold increase in SKOV-3 tumor targeting was achieved when [Co-57]Co-HP2 (0.7 nmol) was injected 48 h after injection of trastuzumab-ZHP1 (0.5 nmol) compared with trastuzumab-ZHP1 alone (0.8 +/- 0.2 vs. 0.33 +/- 0.06 %ID/g). Tumor accumulation of [Co-57]Co-HP2 was significantly reduced by pre-saturation with trastuzumab or when no trastuzumab-ZHP1 was preinjected. A tumor-to-blood uptake ratio of 1.5 +/- 0.3 was achieved resulting in a clear visualization of HER2-expressing xenografts as confirmed by SPECT imaging. In conclusion, the feasibility of stable site-specific coupling of a PNA-based recognition tag to trastuzumab and successful pretargeting has been demonstrated. This approach can hopefully be used for a broad range of mAbs and recognition tags.

  • Ablikim, M.
    et al.
    Andersson, Walter Ikegami
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Search for the decay D-s(+) -> gamma e (+) nu(e)2019In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 99, no 7, article id 072002Article in journal (Refereed)
    Abstract [en]

    A search for the rare radiative leptonic decay D-s(+) -> gamma e(+)nu(e) is performed for the first time using electron-positron collision data corresponding to an integrated luminosity of 3.19 fb(-1), collected with the BESIII detector at a center-of-mass energy of 4.178 GeV. No evidence for the D-s(+) -> gamma e(+)nu(e) decay is seen, and an upper limit of beta(D-s(+) -> gamma e(+)nu(e)) < 1.3 x 10(-4) is set on the partial branching fraction at a 90% confidence level for radiative photon energies E-gamma* > 0.01 GeV.

  • Carstensen, Gunilla
    et al.
    DalarnaUniv, Sch Technol & Business Studies, Falun, Sweden.
    Rosberg, Birgitta
    Uppsala Univ Hosp, Akad Sjukhuset, Dept Rehabil Med, Uppsala, Sweden.
    Mc Kee, Kevin J.
    Dalarna Univ, Sch Educ Hlth & Social Studies, S-79188 Falun, Sweden.
    Åberg, Anna Cristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Dalarna Univ, Sch Educ Hlth & Social Studies, S-79188 Falun, Sweden.
    Before evening falls: Perspectives of a good old age and healthy ageing among oldest-old Swedish men2019In: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 82, p. 35-44Article in journal (Refereed)
    Abstract [en]

    The late life experiences of men in the oldest-old age group have been under-researched, and their perspectives on ageing successfully neglected. This study explored the perspectives of oldest-old Swedish men on what a 'good old age' and ageing successfully meant to them. A purposive sample of 17 men, aged 85-90 years, was drawn from the Uppsala Longitudinal Study of Adult Men. An interview guide explored participants' perspectives on their ageing experiences and how they viewed ageing successfully. Participants were interviewed twice, with 1-2 weeks between interviews, and both interviews were recorded and transcribed. Content analysis identified four themes: i) Adaptation, concerning the ability to adapt to growing old with increasing limitations; ii) Sustaining Independence, related to financial resources and good health as the foundation for independence; iii) Belongingness, representing close relationships, established friendships, and the significance of the spouse; and iv) Perspectives of Time, also a common thread in all themes, in which past life experiences create an existential link between the past, the present and the future, establishing continuity of the self and enhancing life satisfaction. The participants presented themselves as active agents involved in maintaining meaning and achieving life satisfaction; a process related to the ability to manage changes in life. Our findings have resonance with models of healthy or successful ageing, but also diverge in important ways, since such models do not consider the significance of an individual's life history for their present well-being, and primarily conceptualise health as an outcome, rather than as a resource.

  • Käll, Emma
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Jeppesen, Kajsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Det tysta moderskapet: Kvinnors upplevda barriärer för att söka hjälp för postpartumdepression2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Postpartum depression affects around 8-15 percent of women who have given birth. Symptoms present within a few weeks and can last upwards of a year; and cause a great deal of suffering to the women experiencing it. Evidence suggests women do not seek help for their depressive symptoms, which highlights the need of nurses to identify symptoms and offer treatment and support.

    Aim: The aim of this literature review is to examine the experienced barriers among women to seek help for postpartum depression.

    Method: The studies analysed in this literature review were chosen from the databases PubMed and CINAHL. Ten studies were included. Quality of the articles was identified using a criteria and three categories were found within the findings.

    Results: The three categories concerned the women, their surrounding and the health care as barriers. Stigmatisations attached to mental healt issues and the ‘ideal’ image of motherhood created a major barrier to seek help. Women experienced a lack of knowledge and understanding of PPD, they often normalised the symptoms and explained them with external factors. A lack of support from health care also posed as barriers when seeking help.

    Conclusion: Women experience numerous stigmatisations related to mental health issues and the ‘ideal’ image of motherhood, which figured as a major barrier to seek help. This study reiterates the importance of having supportive health care; with the nurse playing an important role in breaking this stigma and creating a safe environment for women to share their experiences.

  • Lundqvist, Madeleine
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Öhrn, Julia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Känslor hos en tonåring och dennes familj i samband med en cancerdiagnos: En litteraturöversikt2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Puberty may be a difficult time for adolescents. Being diagnosed with cancer at that time can be hard for both the adolescent and its family. What need to be examined more detailed are which emotions that can arise in an adolescent and its family in conjunction with a cancer diagnosis.

    Aim: To examine which emotions can arise in an adolescent and its family members in connection with a cancer diagnosis.

    Method: A descriptive literature study as a method was used. Eleven qualitative studies from CINAHL, PsycInfo and PubMed was received and the results that answered to the purpose of this study got complied. Joyce Travelbees nursing theory was used.

    Results: The cancer diagnosis affected both the adolescent and the family members, which often brought reactions of shock. Feelings like anger, fear and worry were some that frequently occurred. Thoughts surrounding death, the eventual body change often appeared as well as feelings of injustice. It’s important that the actions from health professionals are supporting and permeated by sympathy along with empathy. Every conversation with the involved should be individualized, age adopted and informative.

    Conclusion: When healthcare professionals respond to a shocked adolescent and family, the conversation should be personalized. Along with the shock, the parties involved can among other things feel fear, sadness and uncertainty about the future. Simultaneously with the puberty, the cancer diagnosis can contribute to a complex self-image. Further Research on the subject is required to clarify the exact psychosocial approach in the diagnosis stage.

  • Berglund, Charlotte
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hemmingsson, Ebba
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Jämlik cancervård?: En litteraturöversikt om socioekonomiska skillnader i den skandinaviska cancervården2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: After diseases of the circulatory organs, cancer causes most deaths in Sweden. Previous studies indicate an effect of socioeconomic factors on the risk for being diagnosed with, as well as on survival of cancer in general. Furthermore, disparities in the quality of cancer care, related to socioeconomic status, has been exposed. But what is the current situation regarding disease detection, waiting times and treatment within the Scandinavian cancer care? Do all patients receive equal cancer care and treatment, regardless of socioeconomic status?  Aim: To compile existing literature on disparities in disease detection, waiting times and treatment for patients with different socioeconomic status within the Scandinavian cancer care.  Method: A literature review, including 13 articles of quantitative methodology, reflecting Scandinavian conditions. PubMed and CINAHL were used for data collection. The review is based on the nursing theory by Katie Eriksson. Deductive method was used for the implementation of the results analysis.  Results: The results are presented within three main categories; socioeconomic disparities in disease detection, waiting times and treatment. Cancer is detected earlier among patients with higher education and/or income. These patients also have considerably lower risk of being in an advanced stage of disease at the time of diagnosis. Patients with high socioeconomic status also receive more, and more advanced treatment, compared with patients with lower socioeconomic status.   Conclusion: The Scandinavian tax-funded cancer care is not equal. Not all patients receive equal care and treatment regardless of socioeconomic status. Cancer is detected at an earlier stage among patients with high education or high income, and they receive more treatment, in comparison to individuals with lower socioeconomic status, who are being disadvantaged.

  • Paçacı, Görkem
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Johnson, David
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    McKeever, Steve
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Hamfelt, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    "Why did you do that?": Explaining black box models with Inductive Synthesis2019In: International Conference on Computational Science (ICCS), Faro, Algarve, Portugal, 12-14 June 2019, 2019Conference paper (Refereed)
    Abstract [en]

    By their nature, the composition of black box models is opaque. This makes the ability to generate explanations for the response to stimuli challenging. The importance of explaining black box models has become increasingly important given the prevalence of AI and ML systems and the need to build legal and regulatory frameworks around them. Such explanations can also increase trust in these uncertain systems. In our paper we present RICE, a method for generating explanations of the behaviour of black box models by (1) probing a model to extract model output examples using sensitivity analysis; (2) applying CNPInduce, a method for inductive logic program synthesis, to generate logic programs based on critical input-output pairs; and (3) interpreting the target program as a human-readable explanation. We demonstrate the application of our method by generating explanations of an artificial neural network trained to follow simple traffic rules in a hypothetical self-driving car simulation. We conclude with a discussion on the scalability and usability of our approach and its potential applications to explanation-critical scenarios.

  • Lindmark, Krister
    et al.
    Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden;Umea Univ Hosp, Heart Ctr, S-90187 Umea, Sweden.
    Boman, Kurt
    Umea Univ, Res Unit, Med Geriatr, Skelleftea Cty Hosp,Dept Publ Hlth & Clin Med, Umea, Sweden.
    Olofsson, Mona
    Umea Univ, Res Unit, Med Geriatr, Skelleftea Cty Hosp,Dept Publ Hlth & Clin Med, Umea, Sweden.
    Tornblom, Michael
    IQVIA, Real World & Analyt Solut, Solna, Sweden.
    Levine, Aaron
    IQVIA, Real World & Analyt Solut, Solna, Sweden.
    Castelo-Branco, Anna
    IQVIA, Real World & Analyt Solut, Solna, Sweden.
    Schlienger, Raymond
    Novartis Pharma AG, Quantitat Safety & Epidemiol, Basel, Switzerland.
    Wirta, Sara Bruce
    Novartis Sweden AB, Global RWE Cardiometabol, Stockholm, Sweden.
    Stålhammar, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Wikström, Gerhard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden2019In: Clinical Epidemiology, ISSN 1179-1349, E-ISSN 1179-1349, Vol. 11, p. 231-244Article in journal (Refereed)
    Abstract [en]

    Purpose: The purpose of this study was to examine the trends in heart failure (HF) epidemiology and diagnostic work-up in Sweden.

    Methods: Adults with incident HF (>= 2 ICD-10 diagnostic codes) were identified from linked national health registers (cohort 1, 2005-2013) and electronic medical records (cohort 2, 2010-2015; primary/secondary care patients from Uppsala and Vasterbotten). Trends in annual HF incidence rate and prevalence, risk of all-cause and cardiovascular disease (CVD)-related 1-year mortality and use of diagnostic tests 6 months before and after first HF diagnosis (cohort 2) were assessed.

    Results: Baseline demographic and clinical characteristics were similar for cohort 1 (N=174,537) and 2 (N=8,702), with mean ages of 77.4 and 76.6 years, respectively; almost 30% of patients were aged >= 85 years. From 2010 to 2014, age-adjusted annual incidence rate of HF/1,000 inhabitants decreased (from 3.20 to 2.91, cohort 1; from 4.34 to 3.33, cohort 2), while age-adjusted prevalence increased (from 1.61% to 1.72% and from 2.15% to 2.18%, respectively). Age-adjusted 1-year all-cause and CVD-related mortality was higher in men than in women among patients in cohort 1 (all-cause mortality hazard ratio [HR] men vs women 1.07 [95% CI 1.06-1.09] and CVD-related mortality subdistribution HR for men vs women 1.04 [95% CI 1.02-1.07], respectively). While 83.5% of patients underwent N-terminal pro-B-type natriuretic peptide testing, only 36.4% of patients had an echocardiogram at the time of diagnosis, although this increased overtime. In the national prevalent HF population (patients with a diagnosis in 1997-2004 who survived into the analysis period; N=273,999), death from ischemic heart disease and myocardial infarction declined between 2005 and 2013, while death from HF and atrial fibrillation/flutter increased (P<0.0001 for trends over time).

    Conclusion: The annual incidence rate of HF declined over time, while prevalence of HF has increased, suggesting that patients with HF were surviving longer over time. Our study confirms that previously reported epidemiological trends persist and remain to ensure proper diagnostic evaluation and management of patients with HF.

  • Elestedt, Amanda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Barnets bästa i den europeiska internationella privat- och processrätten: En analys av Bryssel IIa-förordningens behörighetsregler i mål om föräldraansvar2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Public defence: 2019-05-17 09:00 Axel Hambergsalen, Uppsala
    Nordström, Albin
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Biogeochemical Processes in Denitrifying Woodchip Bioreactors and their Application in the Mining Industry2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis evaluates passive denitrifying woodchip bioreactors (DWBs) for the removal of nitrate (NO3-) in neutral pH mine drainage, where water is passed through a carbon-rich porous matrix (e.g. woodchips) for the reduction of NO3- to nitrogen gas. DWBs have been used for the removal of NO3- from water in various settings and are expected to operate with little maintenance for at least a decade; however, the processes controlling the emission of greenhouse gases and other undesirable by-products, as well as the magnitude and variability in NO3- removal rates and how these develop over time, are not completely understood and were the focus of this thesis.

    Water treatment in DWBs was investigated in laboratory-scale column tests and in a pilot-scale bioreactor installed at the Kiruna iron ore mine, northern Sweden. Denitrification was the major pathway for NO3- removal in both experimental systems. Incoming NO3- concentrations (up to 30.0 mg N L-1) were removed to below detection limits at temperatures and hydraulic residence times (HRTs) between 5-22°C and ~1.9-2.6 days, respectively, without substantial production of nitrite or ammonium (NH4+). NO3- removal was incomplete in both systems when HRTs decreased to ~1 day, and/or as temperature decreased below 5°C in the pilot-scale bioreactor, under which conditions an increased production of nitrous oxide (N2O) and NH4+ was observed (relative to the NO3- reduced).

    In the column tests, non-ideal flow was detected and solute transport was described using a dual-porosity model. Stagnant zones not transmitting flow did not participate in NO3- removal and the fraction of immobile water increased with increases in the advection velocity, suggesting that bioreactor performance could be enhanced by emphasizing design with low advection velocities.  

    The study demonstrated that dominating biogeochemical processes varied with time in the pilot-scale bioreactor. There was a decline in organic carbon export and increase in pH and alkalinity that, based on a stoichiometric mass-balance, was suggested to be the result of a change in fermentation end-products that provided a carbon source to the denitrifying community. The decline in NO3- removal rates and biogeochemical process diversity, and the preferential selection of denitrifiers with the genetic capacity for reduction to N2O, but not N2, are hypothesized to arise from the temporal development of syntrophic structures between fermenters and denitrifiers.

    List of papers
    1. Denitrification in a low-temperature bioreactorsystem at two different hydraulic residence times: laboratory column studies
    Open this publication in new window or tab >>Denitrification in a low-temperature bioreactorsystem at two different hydraulic residence times: laboratory column studies
    2017 (English)In: Environmental technology, ISSN 0959-3330, E-ISSN 1479-487X, Vol. 38, no 11, p. 1362-1375Article in journal (Refereed) Published
    Abstract [en]

    Nitrate removal rates in a mixture of pine woodchips and sewage sludge were determined in laboratory column studies at 5°C, 12°C, and 22°C, and at two different hydraulic residence times (HRTs; 58.2–64.0 hours and 18.7–20.6 hours). Baffles installed in the flow path were tested as a measure to reduce preferential flow behavior, and to increase the nitrate removal in the columns. The nitrate removal in the columns was simulated at 5°C and 12°C using a combined Arrhenius-Monod equation controlling the removal rate, and a first-order exchange model for incorporation of stagnant zones. Denitrification in the mixture of pine woodchips and sewage sludge reduced nitrate concentrations of 30 mg N L−1 at 5°C to below detection limits at a HRT of 58.2–64.0 hours. At a HRT of 18.7–20.6 hours, nitrate removal was incomplete. The Arrhenius frequency factor and activation energy retrieved from the low HRT data supported abiochemically controlled reaction rate; the same parameters, however, could not be used to simulate the nitrate removal at high HRT. The results show an inversely proportional relationship between the advection velocity and the nitrate removal rate, suggesting that bioreactor performance could be enhanced by promoting low advection velocities.

    National Category
    Oceanography, Hydrology and Water Resources
    Research subject
    Hydrology
    Identifiers
    urn:nbn:se:uu:diva-303686 (URN)10.1080/09593330.2016.1228699 (DOI)000400464400004 ()27603564 (PubMedID)
    Projects
    MiNing
    Funder
    VINNOVA, P31054-1
    Available from: 2016-09-22 Created: 2016-09-22 Last updated: 2019-03-27Bibliographically approved
    2. Determination of major biogeochemical processes in a denitrifying woodchip bioreactor for treating mine drainage
    Open this publication in new window or tab >>Determination of major biogeochemical processes in a denitrifying woodchip bioreactor for treating mine drainage
    2018 (English)In: Ecological Engineering: The Journal of Ecotechnology, ISSN 0925-8574, E-ISSN 1872-6992, Vol. 110, p. 54-66Article in journal (Refereed) Published
    Abstract [en]

    At the Kiruna iron ore mine in northern Sweden, mine drainage and process water contain elevated concentrationsof nitrate (NO3−) from the use of ammonium nitrate fuel oil explosives. In order to investigate thetreatment capacity of a denitrifying woodchip bioreactor technique for the removal of NO3− through denitrification,a bioreactor was installed at the mine site in 2015 and operated for two consecutive years. Neutral-pHmine drainage and process water containing 22 mg NO3−-N and 1132 mg SO42− (average) was passed throughthe bioreactor which was filled with a reactive mixture of pine woodchips and sewage sludge, at treatmenttemperatures ranging between 0.8 and 17 °C. At bioreactor temperatures above ∼5 °C, NO3− removal proceededto below detection limits (0.06 mg N L−1) without substantial production of nitrite (NO2−), ammonium(NH4+), nitrous oxide (N2O), or methane (CH4). The relative production of NH4+ and N2O to the NO3− reducedincreased as bioreactor temperatures decreased below ∼5 °C. Based on the resultant changes in alkalinity andpH from the production of bicarbonate (HCO3−) and carbonic acid (H2CO3), a stoichiometric mass balancemodel indicated that denitrification, nitrate reduction to ammonium (DNRA), sulfate reduction, and fermentationwere the major biogeochemical processes controlling pH, alkalinity and nitrogen, sulfur and carbonconcentrations in the system. It is suggested that fermentation changed from being mainly butyrate producing toacetate producing with time, triggering a decline in biogeochemical process diversity and leaving denitrificationas the sole major electron accepting process.

    Keywords
    Denitrification, sulfate reduction, DNRA, woodchip bioreactor, temperature, biogeochemical processes, mine drainage, nitrogen, denitrifikation, sulfatreduktion, DNRA, bioreaktor med träflis, temperatur, biogeokemiska processes, gruvvatten, kväve
    National Category
    Geochemistry
    Research subject
    Hydrology
    Identifiers
    urn:nbn:se:uu:diva-331698 (URN)10.1016/j.ecoleng.2017.09.018 (DOI)000417048500007 ()
    Projects
    miNing
    Funder
    VINNOVA, 2014-01134
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2019-03-27Bibliographically approved
    3. Identification of the temporal control on nitrate removal rate variability in a denitrifying woodchip bioreactor
    Open this publication in new window or tab >>Identification of the temporal control on nitrate removal rate variability in a denitrifying woodchip bioreactor
    2019 (English)In: Ecological Engineering: The Journal of Ecotechnology, ISSN 0925-8574, E-ISSN 1872-6992, Vol. 127, p. 88-95Article in journal (Refereed) Published
    Abstract [en]

    Nitrate (NO3) removal rates in a denitrifying woodchip bioreactor (DWB) removing NO3 from mine water in a subarctic climate was modeled with the purpose of determining the processes controlling variability in NO3 removal rates over time. The Eyring equation was used to define the temperature dependency, while a rate law was used to describe the NO3 concentration dependency of the NO3 removal rates. The results show that the temperature and NO3 concentration dependency of the NO3 removal rates changes over time in the DWB due to the preferential selection of conceptualized NO3 - reducing bacteria favoring low temperatures, with the mean temperature optimum of the NO3 reducing consortium decreasing from 24.2 °C to 16.0 °C following the first year of DWB operations. It is suggested that the selection of the low temperature NO3 reducers in the DWB represented an increased dependence on cross-feeding between a fermentative community, producing the reactive organic carbon substrate, and a denitrifying community, consuming the organic carbon substrate, with the temporal variability in NO3 removal rates being controlled by the stabilization of the microbial community structure. It is also suggested that the life expectancy of DWBs is more related to the stability of the cross-feeding between the fermenting microbial community and the denitrifying microbial community, than to the total carbon content.

    Keywords
    Woodchip bioreactor, Modeling, Macromolecular rate theory, Selection, Temperature, Longevity
    National Category
    Water Treatment
    Identifiers
    urn:nbn:se:uu:diva-366588 (URN)10.1016/j.ecoleng.2018.11.015 (DOI)000455632500009 ()
    Funder
    VINNOVA, 2014-01134
    Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2019-03-27Bibliographically approved
    4. Microbial Controls on Net Production of NOx Species in a Denitrifying Woodchip Bioreactor
    Open this publication in new window or tab >>Microbial Controls on Net Production of NOx Species in a Denitrifying Woodchip Bioreactor
    (English)Manuscript (preprint) (Other academic)
    National Category
    Water Treatment
    Identifiers
    urn:nbn:se:uu:diva-380384 (URN)
    Projects
    miNing
    Funder
    Vinnova, 2014-011334
    Available from: 2019-03-27 Created: 2019-03-27 Last updated: 2019-03-27
  • Chen, Weili
    et al.
    Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou 510006, Guangdong, Peoples R China;Sun Yat Sen Univ, Natl Engn Res Ctr Digital Life, Guangzhou 510006, Guangdong, Peoples R China.
    Zheng, Zibin
    Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou 510006, Guangdong, Peoples R China;Sun Yat Sen Univ, Natl Engn Res Ctr Digital Life, Guangzhou 510006, Guangdong, Peoples R China.
    Ngai, Edith
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Zheng, Peilin
    Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou 510006, Guangdong, Peoples R China;Sun Yat Sen Univ, Natl Engn Res Ctr Digital Life, Guangzhou 510006, Guangdong, Peoples R China.
    Zhou, Yuren
    Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou 510006, Guangdong, Peoples R China;Sun Yat Sen Univ, Natl Engn Res Ctr Digital Life, Guangzhou 510006, Guangdong, Peoples R China.
    Exploiting Blockchain Data to Detect Smart Ponzi Schemes on Ethereum2019In: IEEE Access, E-ISSN 2169-3536, Vol. 7, p. 37575-37586Article in journal (Refereed)
    Abstract [en]

    Blockchain technology becomes increasingly popular. It also attracts scams, for example, a Ponzi scheme, a classic fraud, has been found making a notable amount of money on Blockchain, which has a very negative impact. To help to deal with this issue and to provide reusable research data sets for future research, this paper collects real-world samples and proposes an approach to detect Ponzi schemes implemented as smart contracts (i.e., smart Ponzi schemes) on the blockchain. First, 200 smart Ponzi schemes are obtained by manually checking more than 3,000 open source smart contracts on the Ethereum platform. Then, two kinds of features are extracted from the transaction history and operation codes of the smart contracts. Finally, a classification model is presented to detect smart Ponzi schemes. The extensive experiments show that the proposed model performs better than many traditional classification models and can achieve high accuracy for practical use. By using the proposed approach, we estimate that there are more than 500 smart Ponzi schemes running on Ethereum. Based on these results, we propose to build a uniform platform to evaluate and monitor every created smart contract for early warning of scams.

  • Public defence: 2019-05-16 09:15 C4:305, Uppsala
    Salomonsson, Maya
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    New Aspects of Mast Cell Progenitors in Health and Disease2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Mast cells are tissue-resident immune cells that are well known for their involvement in asthma and allergy. They originate in the fetal yolk sac, or in the bone marrow. From the bone marrow, they are released as immature progenitors that are transported via the blood circulation to the peripheral tissue, where they mature. Human mast cells accumulate at certain sites in the airways of individuals with asthma, and in a mouse model of allergic airway inflammation, an influx of mast cell progenitors (MCp) to the lung has been demonstrated. We quantified MCp frequency by flow cytometry to determine if there is a correlation between MCp frequency and reduced lung function among allergic asthmatics and controls. We found that individuals with reduced lung function had an increased MCp frequency in the blood circulation. Additionally, women had a higher MCp frequency than men. 

    In the second study, we identified a bone marrow counterpart to the human blood MCp. These two MCp populations had similar mast cell-related gene expression, morphology and proliferation capacity. However, the blood MCp expressed higher levels of the integrin β7 receptor, which in mice has been shown to be required for MCp transmigration into peripheral tissues. 

    Mast cells can be activated by antigen crosslinking of IgE bound to FcεRI. Both human and mouse MCp express FcεRI, but it is unknown whether they can be activated via this receptor. In the third study, we demonstrated that human and mouse MCp can become activated in vitro via FcεRI by measuring tyrosine kinases phosphorylation by flow cytometry. Furthermore, we showed the activation in vivo by measuring IL-13 production in MCp in an allergic airway inflammation model.

    In the final study, we investigated the chemokine receptor expression on mouse MCp. We found that MCp in the peritoneal cavity express CCR5 whereas bone marrow MCp express CCR1. 

    To summarize, my thesis has provided novel insights into the significance of circulating human MCp, and reveled an MCp population in human bone marrow. Moreover, the data presented suggest that MCp can be activated and that their chemokine receptor expression depends on tissue localization. 

    List of papers
    1. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma
    Open this publication in new window or tab >>Circulating mast cell progenitors correlate with reduced lung function in allergic asthma
    Show others...
    2019 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222Article in journal (Refereed) Accepted
    National Category
    Immunology
    Identifiers
    urn:nbn:se:uu:diva-379233 (URN)10.1111/cea.13388 (DOI)
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26
    2. Demonstration of human mast cell progenitors in the bone marrow
    Open this publication in new window or tab >>Demonstration of human mast cell progenitors in the bone marrow
    (English)Manuscript (preprint) (Other academic)
    National Category
    Immunology
    Identifiers
    urn:nbn:se:uu:diva-379232 (URN)
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26
    3. Mast cell progenitors can be activated by IgE crosslinking
    Open this publication in new window or tab >>Mast cell progenitors can be activated by IgE crosslinking
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Immunology
    Identifiers
    urn:nbn:se:uu:diva-379231 (URN)
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26
    4. Differential expression of CCR1 and CCR5 on murine mast cell progenitors depending on tissue localization
    Open this publication in new window or tab >>Differential expression of CCR1 and CCR5 on murine mast cell progenitors depending on tissue localization
    (English)Manuscript (preprint) (Other academic)
    National Category
    Immunology
    Identifiers
    urn:nbn:se:uu:diva-379230 (URN)
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26
  • Cazzaniga, Walter
    et al.
    IRCCS Osped San Raffaele, URI, Unit Urol, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy.
    Ventimiglia, Eugenio
    IRCCS Osped San Raffaele, URI, Unit Urol, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy.
    Alfano, Massimo
    IRCCS Osped San Raffaele, URI, Unit Urol, Div Expt Oncol, Milan, Italy.
    Robinson, David
    Ryhov Hosp, Dept Urol, Jonkoping, Sweden.
    Lissbrant, Ingela Franck
    Univ Goteborg, Sahlgrenska Acad, Dept Oncol, Inst Clin Sci, Gothenburg, Sweden.
    Carlsson, Stefan
    Karolinska Univ Hosp, Div Urol, Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg MMK, Stockholm, Sweden.
    Styrke, Johan
    Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.
    Montorsi, Francesco
    IRCCS Osped San Raffaele, URI, Unit Urol, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy.
    Salonia, Andrea
    IRCCS Osped San Raffaele, URI, Unit Urol, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy.
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Mini Review on the Use of Clinical Cancer Registers for Prostate Cancer: The National Prostate Cancer Register (NPCR) of Sweden2019In: FRONTIERS IN MEDICINE, ISSN 2296-858X, Vol. 6, article id 51Article, review/survey (Refereed)
    Abstract [en]

    Given the increasing prevalence of cancer, it is vital to systematically collect data in order to monitor disease trends and quality of cancer care. For this purpose, clinical cancer registries have been developed in some countries. These registers are intended to be used as a basis for quality assurance and quality improvement, but they also constitute a rich resource of real world data for research. The aim of thismini-review was to describe the structure and the organization of the National Prostate Cancer Register (NPCR) with some examples on how data in NPCR have affected prostate cancer care in Sweden.

  • Andersson, Oskar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Eskatologiska tendenser i Svenska kyrkan: En analys av Svenska kyrkans biskopsbrev2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats kommer att undersöka om det går att dra eskatologiska slutsatser från Svenska kyrkans biskopsmöte genom dess biskopsbrev. Uppsatsens idé är sprungen från det prästlöfte som prästen avlägger i sin vigning. Löftet om att rent och klart förkunna Svenska kyrkans tro och lära. Svenska kyrkan tro och bekännelse är reglerad genom kyrkomötets officiellt bejakade dokument. Dessa dokument är den heliga skriften, trosbekännelser, historiska lärodokument och bekännelser, handböcker, psalmboken och andra samtida bejakade och fastslagna dokument av Svenska kyrkans kyrkomöte. Svenska kyrkans kyrkoordning konstaterar att det är kyrkans uppgift att i varje tid tolka och utlägga vad tron och läran innebär för kyrkan och den enskilda kristna i dess samtid.

    Häri finns en problematik av att Svenska kyrkans ledning ofta är motvillig till att fastslå vad som är dess tolkning av sin tro och lära i olika dogmer eller andra lärodokument. Detta kan skapa problem för den enskilda predikanten när det gäller att i sin tid just tolka och utlägga Svenska kyrkans tro och lära. Svenska kyrkan har olika institutioner som på olika sätt reglerar hur kyrkans tro och lära ska uppfattas. Dessa institutioner är kyrkomötet, domkapitel, läronämnden och biskopsmötet. Jag har valt att inrikta uppsatsen till att granska biskopsmötet funktion som en av de normerande instanserna för hur Svenska kyrkans ska tolka sin tro och lära. Tolkningsarbete gör biskopsmötet bland annat genom att skriva biskopsbrev. Biskopsbreven har en normerande funktion för hur Svenska kyrkan ska uppfatta och tolka sin tro och lära. Det som kommer att undersöka i uppsatsen är alltså att undersöka vilken eskatologisk lära som uttrycks i Svenska kyrkans biskopsbrev.

  • Public defence: 2019-05-16 09:15 Enghoffsalen, Uppsala
    Franzon, Kristin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Independent Ageing in Very Old Swedish Men2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Predictors for survival have been investigated thoroughly, but less is known about how to reach high age with preserved physical and cognitive function. These functions are crucial to stay independent in daily life, which is highly valued by the oldest old.

    This thesis was based on data from the Uppsala Longitudinal Study in Adult Men. In 1970, all men born in 1920-24 and living in Uppsala were invited to the study, and 82% (n=2,322) participated in the first investigation. In this thesis, data are used from the investigations cycles at the ages of 50, 71, 87 and 92 years. Independent ageing was defined as follows: having independency in personal care and the ability to walk outdoors alone, being community-dwelling, having a Mini-Mental State Examination score of 25 points or greater, and having no diagnosed dementia.

    Thirty-seven percent of the original cohort survived to the age of 85. At a mean age of 87, 74% of the participants were independently aged, while at a mean age of 92 the prevalence of independent ageing was 64%. In Paper I, non-smoking and normal weight at a mean age of 50 were associated with independent ageing at a mean age of 87 years. In Paper II, never smoking, not being obese, and a high adherence to a Mediterranean-like diet at a mean age of 71 were associated with independent ageing at a mean age of 87. In both Papers I and II, high leisure time physical activity was associated with survival, but not with independent ageing. In Paper III, higher gait speed and hand grip strength and a faster chair stand test were cross-sectionally associated with independent ageing at a mean age of 87. Higher gait speed was also longitudinally associated with independent ageing five years. However, muscle mass and sarcopenia were not associated with the outcome. In Paper IV, a history of stroke, osteoarthritis, hip fracture and chronic obstructive pulmonary disease were associated with loss of independent ageing at a mean age of 92.

    Smoking, weight and diet are all modifiable risk factors associated with independent ageing. If decreased smoking and a normalised weight in the population could diminish stroke, hip fracture, chronic obstructive pulmonary disease and osteoarthritis, the prevalence of independent ageing could rise, even in nonagenarians. Additionally, a Mediterranean-like diet may contribute to both survival and independent ageing.

    List of papers
    1. Modifiable Midlife Risk Factors, Independent Aging, and Survival in Older Men: Report on Long-Term Follow-Up of the Uppsala Longitudinal Study of Adult Men Cohort
    Open this publication in new window or tab >>Modifiable Midlife Risk Factors, Independent Aging, and Survival in Older Men: Report on Long-Term Follow-Up of the Uppsala Longitudinal Study of Adult Men Cohort
    2015 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 63, no 5, p. 877-885Article in journal (Refereed) Published
    Abstract [en]

    ObjectivesTo examine relationships between modifiable midlife factors, aging, and physical and cognitive function (independent aging) and survival in very old age. DesignProspective cohort. SettingUppsala Longitudinal Study of Adult Men, Uppsala, Sweden. ParticipantsSwedish men investigated in 1970-74 (aged 48.6-51.1) and followed up for four decades (N=2,293). MeasurementsConventional cardiovascular risk factors, body mass index (BMI), and dietary biomarkers were measured, and a questionnaire was used to gather information on lifestyle variables at age 50. Four hundred seventy-two men were reinvestigated in 2008-09 (aged 84.8-88.9). Independent aging was defined as survival to age 85, Mini-Mental State Examination score of 25 or greater, not living in an institution, independent in personal care and hygiene, able to walk outdoors without personal help, and no diagnosis of dementia. The National Swedish Death Registry provided survival data. ResultsThirty-eight percent of the cohort survived to age 85. Seventy-four percent of the participants in 2008-09 were aging independently. In univariable analyses, high leisure-time physical activity predicted survival but not independent aging. Low work-time physical activity was associated more strongly with independent aging (odds ratio (OR)=1.84, 95% confidence interval (CI)=1.18-2.88) than with survival (OR=1.27, 95% CI=1.05-1.52). In multivariable analyses, midlife BMI was negatively associated (OR=0.80/SD, 95% CI=0.65-0.99/SD), and never or former smoking was positively associated (OR=1.66, 95% CI=1.07-2.59), with independent aging. As expected, conventional cardiovascular and lifestyle risk factors were associated with mortality. ConclusionA normal midlife BMI and not smoking were associated with independent aging close to four decades later, indicating that normal weight at midlife has the potential not only to increase survival, but also to preserve independence with aging.

    Keywords
    independent aging, successful aging, obesity, smoking, longitudinal
    National Category
    Geriatrics
    Identifiers
    urn:nbn:se:uu:diva-256538 (URN)10.1111/jgs.13352 (DOI)000354726400005 ()25919442 (PubMedID)
    Available from: 2015-06-25 Created: 2015-06-24 Last updated: 2019-03-26Bibliographically approved
    2. Predictors of Independent Aging and Survival: A 16-Year Follow-Up Report in Octogenarian Men
    Open this publication in new window or tab >>Predictors of Independent Aging and Survival: A 16-Year Follow-Up Report in Octogenarian Men
    Show others...
    2017 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 65, no 9, p. 1953-1960Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVES: To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors.

    DESIGN: Cohort study.

    SETTING: Uppsala Longitudinal Study of Adult Men, Sweden.

    PARTICIPANTS: Swedish men (n = 1,104) at a mean age of 71 (range 69.4-74.1) were investigated, 369 of whom were evaluated for independent aging 16 years later, at a mean age of 87 (range 84.8-88.9).

    MEASUREMENTS: A questionnaire was used to obtain information on lifestyle, including education, living conditions, and physical activity. Adherence to a Mediterranean-like diet was assessed according to a modified Mediterranean Diet Score derived from 7-day food records. Cardiovascular risk factors were measured. Independent aging at a mean age of 87 was defined as lack of diagnosed dementia, a Mini-Mental State Examination score of 25 or greater, not institutionalized, independence in personal activities of daily living, and ability to walk outdoors alone. Complete survival data at age 85 were obtained from the Swedish Cause of Death Register.

    RESULTS: Fifty-seven percent of the men survived to age 85, and 75% of the participants at a mean age of 87 displayed independent aging. Independent aging was associated with never smoking (vs current) (odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.05-4.60) and high (vs low) adherence to a Mediterranean-like diet (OR = 2.69, 95% CI = 1.14-6.80). Normal weight or overweight and waist circumference of 102 cm or less were also associated with independent aging. Similar associations were observed with survival.

    CONCLUSION: Lifestyle factors such as never smoking, maintaining a healthy diet, and not being obese at age 71 were associated with survival and independent aging at age 85 and older in men.

    Keywords
    Mediterranean diet, healthy aging, longitudinal, obesity, smoking
    National Category
    Geriatrics Nutrition and Dietetics
    Identifiers
    urn:nbn:se:uu:diva-334423 (URN)10.1111/jgs.14971 (DOI)000411060500016 ()28685810 (PubMedID)
    Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2019-03-26Bibliographically approved
    3. The impact of muscle function, muscle mass and sarcopenia on independent ageing in very old Swedish men
    Open this publication in new window or tab >>The impact of muscle function, muscle mass and sarcopenia on independent ageing in very old Swedish men
    (English)In: Article in journal (Other academic) Submitted
    Keywords
    Sarcopenia, EWGSOP1, EWGSOP2, Muscle mass, Muscle function, Gait speed, Hand grip strength, Chair stand test, Independent ageing
    National Category
    Medical and Health Sciences
    Research subject
    Geriatrics
    Identifiers
    urn:nbn:se:uu:diva-380155 (URN)
    Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-03-26
    4. Influence of somatic morbidity on independent ageing in nonagenarian men. A report from the Uppsala Longitudinal Study of Adult men
    Open this publication in new window or tab >>Influence of somatic morbidity on independent ageing in nonagenarian men. A report from the Uppsala Longitudinal Study of Adult men
    (English)Manuscript (preprint) (Other academic)
    National Category
    Medical and Health Sciences
    Research subject
    Geriatrics
    Identifiers
    urn:nbn:se:uu:diva-380159 (URN)
    Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-03-26
  • Public defence: 2019-05-17 13:15 Sal IX, Uppsala
    Wisell, Kristin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    The Liberalization Experiment: Understanding the political rationales leading to change in pharmacy policy2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In 2009, a pharmacy policy reform was introduced in Sweden whereby the state owned community pharmacy monopoly was abolished. As a result two thirds of the pharmacies were sold. As there were no longer restrictions on ownership and establishment, new pharmacies and new owners appeared. The overall aim of this thesis is to contribute to a more nuanced understanding of the stated and the underlying rationales for the reform, specifically, to understand how key stakeholders view the reform, and the future role of the community pharmacy. Document analysis was the method used to study the preparatory work, plenary debates, and interviews with stakeholders from political, professional and patient organizations.

    The government directive stated that the reform would lead to improvement of availability and efficiency, a pressure on prices and a better use of medicines.  However, the results show that during the reforms’ preparatory phase, the rationales changed and only availability remained throughout the process. Diversity on the market was added later as a rationale. The effects of the reform were perceived in similar ways by the different stakeholder groups. The views on the reform was more negative after the reform.

    Interviewees who were previously in favor of the reform were surprised that diversity had not been achieved; that the counseling in the pharmacies had deteriorated and that the availability of medicines decreased after the reform. Interviewees from political organizations had a more business-oriented view of pharmacies/ists, while participants from professional organizations had a more healthcare-oriented perspective.

    Finally, this thesis studied the diversity rationale behind the pharmacy reform and compared it to the primary care reform. The results show that, in both cases, policy makers definitions of diversity were vague and unclear, which appear to have complicated their implementation.

    Since the pharmacy reform neglected to investigate alternative means of achieving the goals/rationales, it can be argued that the reform was ideologically based and had a preconceived understanding as to how the community pharmacy sector should be regulated. There are several reasons for drawing this conclusion: the reform was launched despite the original rationales being considered as impossible to fulfill, and, except for abolishing the monopoly on state-owned pharmacies, the stakeholders did not seem to know what the reform would lead to, except increasing the number of pharmacies. The latter could have been achieved without the reform as the government had control over the state-owned pharmacy monopoly.

    List of papers
    1. Reregulation of the Swedish pharmacy sector: A qualitative content analysis of the political rationale
    Open this publication in new window or tab >>Reregulation of the Swedish pharmacy sector: A qualitative content analysis of the political rationale
    2015 (English)In: Health Policy, ISSN 0168-8510, E-ISSN 1872-6054, Vol. 119, no 5, p. 648-653Article in journal (Refereed) Published
    Abstract [en]

    In 2009, a reregulation of the Swedish pharmacy sector took place, and a fundamental change in ownership and structure followed. The reregulation provides an opportunity to reveal the politicians' views on pharmacies. The aim of thiS study was to explore and analyze the political arguments for the reregulation of the Swedish pharmacy sector in 2009. The method used was a qualitative content analysis of written political documents regarding the reregulation. The primary rationales for the reregulation were better availability, efficiency, price pressure, and safe usage of medicines. During the preparatory work, the rationales of diversity on the market and entrepreneurship were added, while the original rationales of efficiency, price pressure, and better usage of medicines were abandoned. The reform can be seen as a typical New Public Management reform influenced by the notion that private actors are better equipped to perform public activities. The results point to that the reform was done almost solely in order to introduce private ownership in the pharmacy sector, and was not initiated in order to solve any general problems, or to enhance patient outcomes of medicine use.

    Keywords
    Pharmacy policy, Regulation, Community pharmacy, Sweden
    National Category
    Health Care Service and Management, Health Policy and Services and Health Economy
    Identifiers
    urn:nbn:se:uu:diva-256851 (URN)10.1016/j.healthpol.2015.03.009 (DOI)000355031900011 ()25841749 (PubMedID)
    Available from: 2015-06-26 Created: 2015-06-26 Last updated: 2019-03-24Bibliographically approved
    2. The Raison D’être for the Community Pharmacy and the Community Pharmacist in Sweden: A Qualitative Interview Study
    Open this publication in new window or tab >>The Raison D’être for the Community Pharmacy and the Community Pharmacist in Sweden: A Qualitative Interview Study
    2016 (English)In: Pharmacy, ISSN 2226-4787, Vol. 4, no 1Article in journal (Refereed) Published
    Abstract [en]

    Community pharmacies are balancing between business (selling medicines and other products) and healthcare (using the pharmacists’ knowledge in order to improve drug utilization). This balance could be affected by regulations decided upon by politicians, but also influenced by others. The aim of this study was to explore important stakeholders’ views on community pharmacy and community pharmacists in Sweden. The method used was that of semi-structured qualitative interviews. Political, professional, and patient organization representatives were interviewed.

    The results show that informants who are pharmacists or representatives of a professional pharmacist organization generally have a healthcare-centered view on community pharmacy/pharmacists. However, different views on how this orientation should be performed were revealed, ranging from being specialists to dealing with uncomplicated tasks. Political organization representatives generally had a more business-oriented view, where competition in the market was believed to be the main driving force for development. A third dimension in which competition was not stressed also emerged; that community pharmacies should primarily distribute medicines. This dimension was most prevalent among the political and patient organization representatives. One conclusion to be drawn is that no stakeholder seemed to have a clear vision or was willing to take the lead for the development of the community pharmacy sector.

    Keywords
    community pharmacy; regulation; pharmacy policy; pharmacy reform; legislation; Sweden
    National Category
    Basic Medicine
    Research subject
    Social Pharmacy
    Identifiers
    urn:nbn:se:uu:diva-380060 (URN)10.3390/pharmacy4010003 (DOI)
    Available from: 2019-03-23 Created: 2019-03-23 Last updated: 2019-03-24
    3. Stakeholders’ expectations and perceived effects of the pharmacy ownership liberalization reform in Sweden: a qualitative interview study
    Open this publication in new window or tab >>Stakeholders’ expectations and perceived effects of the pharmacy ownership liberalization reform in Sweden: a qualitative interview study
    2016 (English)In: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 16, article id 379Article in journal (Refereed) Published
    Abstract [en]

    Background: Reforms in the health-care sector, including the pharmacy sector, can have different rationales. The Swedish pharmacies were prior to 2009 organized in a state-owned monopoly. In 2009, a liberalization of the ownership took place, in which a majority of the pharmacies were sold to private owners. The rationales for this liberalization changed profoundly during the preparatory work, making it probable that other rationales than the ones first expressed existed. The aim of this study was to explore the underlying rationales (not stated in official documents) for the liberalization in the Swedish pharmacy sector, and also to compare the expectations with the perceived outcomes.

    Methods: Semi-structured interviews were conducted with representatives from key stakeholder organizations; i.e., political, patient, and professional organizations. The analysis was performed in steps, and themes were developed in an inductive manner.

    Results: One expectation among the political organization participants was that the ownership liberalization would create opportunities for ideas. The competition introduced in the market was supposed to lead to a more diversified pharmacy sector. After the liberalization, the participants in favor of the liberalization were surprised that the pharmacies were so similar.

    Among the professional organization participants, one important rationale for the liberalization was to get better use of the pharmacists’ knowledge. However, all the professional, and some of the patient organization participants, thought that the counseling in the pharmacies had deteriorated after the liberalization.

    As expected in the interviews, the post-liberalization pharmacy sector consists of more pharmacies. However, an unexpected perceived effect of the liberalization was, among participants from all the stakeholder groups, less access to prescription medicines in the pharmacies.

    Conclusions: This study showed that the political organization participants had an ideological basis for their opinion. The political stakeholders did not have a clear view about what the liberalization should lead to, apart from abolishing the monopoly. The perceived effects are quite similar in the different stakeholder groups, and not as positive as were expected.

    Keywords
    community pharamcy, regulation, pharmacy policy, Sweden
    National Category
    Social and Clinical Pharmacy
    Research subject
    Social Pharmacy
    Identifiers
    urn:nbn:se:uu:diva-301433 (URN)10.1186/s12913-016-1637-6 (DOI)000381258500001 ()27519573 (PubMedID)
    Projects
    The monopoly experiment
    Available from: 2016-08-23 Created: 2016-08-23 Last updated: 2019-03-24Bibliographically approved
    4. Diversity as salvation?: A comparison of the diversity rationale in the Swedish pharmacy ownership liberalization reform and the primary care choice reform
    Open this publication in new window or tab >>Diversity as salvation?: A comparison of the diversity rationale in the Swedish pharmacy ownership liberalization reform and the primary care choice reform
    2019 (English)In: Health Policy, ISSN 0168-8510, E-ISSN 1872-6054Article in journal (Refereed) Epub ahead of print
    Abstract [en]

    Widespread liberalizing reform of the Swedish community pharmacy and primary care sectors took place in 2009–2010, including opening the market to private providers. One important rationale for the reforms was to increase diversity in the health-care system by providing more choices for individuals. The aim of this study was to increase the understanding how policy makers understood and defined diversity as a concept, and as a rationale for the reforms. The method used was document analysis of preparatory work and plenary parliament debate protocols. The results show that policy makers held vague and unclear definitions of diversity, which complicated its implementation. Diversity was sometimes seen as an effect of competition–a goal–while in other cases it was seen as a condition to be met in order to achieve competition–a means. Thus, policy makers viewed diversity both as a goal and as a means, making the underlying mechanisms unclear. The findings also revealed that policy makers failed to consistently demonstrate how the introduction of competition would lead to diversity.

    National Category
    Pharmaceutical Sciences
    Research subject
    Social Pharmacy
    Identifiers
    urn:nbn:se:uu:diva-380072 (URN)10.1016/j.healthpol.2019.03.005 (DOI)
    Available from: 2019-03-23 Created: 2019-03-23 Last updated: 2019-03-24
  • Public defence: 2019-05-17 13:15 Häggsalen, 10132, Uppsala
    Chatzigiannakou, Maria Angeliki
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Offshore deployments of marine energy converters2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The depletion warning of non-renewable resources, such as gas, coal and oil, and the imminent effects of climate change turned the attention to clean and fossil fuel-free generated electricity. University research groups worldwide are studying solar, wind, geothermal, biomass and ocean energy harvesting. The focus of this thesis is the wave and marine current energy researched at the division of Electricity at Uppsala University (UU). 

    The main drawbacks that hinder the commercialization of marine energy converter devices is a high installation, operation, maintenance and decommissioning cost. Furthermore, these processes are highly weather dependent and thus, can be time consuming beyond planning. In this thesis, an evaluation of the cost, time and safety efficiency of the devices’ offshore deployment (both wave and marine current), and a comparative evaluation regarding the safety in the use of divers and remotely operated vehicles (ROVs) are conducted. Moreover, a risk analysis study for a common deployment barge while installing an UU wave energy converter (WEC) is presented with the aim to investigate the failure of the crane hoisting system.

    The UU wave energy project have been initiated in 2001, and since then 14 WECs of various designs have been developed and deployed offshore, at the Lysekil research site (LRS), on the Swedish west coast and in Åland, Finland. The UU device is a point absorber with a linear generator power take off. It is secured on the seabed by a concrete gravity foundation. The absorbed wave energy is transmitted to shore through the marine substation (MS) where all the generators are interconnected. In 2008 an UU spin-off company, Seabased AB (SAB), was established and so far has developed and installed several WECs and two MSs, after the UU devices main principle. SAB deployments were conducted in Sotenäs, Sweden, at the Maren test site (MTS) in Norway; and in Ada Foah, Ghana. The active participation and the thorough study of the above deployments led to a cost, time and safety evaluation of the methods followed. Four main methods were identified and the most suitable one can be chosen depending on the deployment type, for example, for single or mass device deployment.

    The first UU full scale marine current energy converter (MCEC) was constructed in 2007 at the Ångström Laboratory and deployed at Söderfors, in the river Dalälven in March 2013. The UU turbine is of a vertical axis type and is connected to a directly driven permanent magnet synchronous generator of a low-speed. With this deployment as an example, four MCEC installation methods were proposed and evaluated in terms of cost and time efficiency.

    A comparative study on the use of divers and ROVs for the deployment and maintenance of WECs at the LRS has been carried out, showing the potential time and costs saved when using ROVs instead of divers in underwater operations. The main restrictions when using divers and ROVs were presented. Most importantly, the modelling introduced is generalized for most types of wave energy technologies, since it does not depend on the structure size or type.

    Finally, a table of safe launch operation of a WEC is presented. In this table the safe, restrictive and prohibitive sea states are found for a single WEC deployment, using a barge and a crane placed on it. The table can be utilized as a guidance for offshore operations safety and can be extended for a variety of device types and vessels.

    List of papers
    1. Offshore Deployments of Wave Energy Converters by Seabased Industry AB
    Open this publication in new window or tab >>Offshore Deployments of Wave Energy Converters by Seabased Industry AB
    2017 (English)In: Journal of Marine Science and Engineering, E-ISSN 2077-1312, Vol. 5, no 2, article id 15Article in journal (Refereed) Published
    Abstract [en]

    Since 2008, Seabased Industry AB (SIAB) has manufactured and deployed several units of wave energy converters (WECs) of different design. The WECs are linear generators with point absorber buoy systems that are placed on the seabed, mounted on a gravitation concrete foundation. These deployments have taken place in different areas, using different deployment vessels. Offshore deployments of WECs and underwater substations have so far been complicated procedures, that were both expensive and time-consuming. The focus of this paper is to discuss these deployments in terms of economy and time efficiency, as well as safety. Because seven vessels have been used to facilitate the deployments, an evaluation on the above basis is carried out for them. The main conclusions and certain solutions are presented for the various problems encountered during these deployments and the vessel choice is discussed. It is found that the offshore deployment process can be optimized in terms of cost, time efficiency and safety with a careful vessel choice, use of the latest available technologies and detailed planning and organizing.

    Keywords
    offshore deployment; wave energy converter; specialized vessel; underwater substation
    National Category
    Marine Engineering
    Identifiers
    urn:nbn:se:uu:diva-318633 (URN)10.3390/jmse5020015 (DOI)000423689700001 ()
    Available from: 2017-03-27 Created: 2017-03-27 Last updated: 2019-04-01Bibliographically approved
    2. Offshore Deployments of Wave Energy Converters by Uppsala University
    Open this publication in new window or tab >>Offshore Deployments of Wave Energy Converters by Uppsala University
    2017 (English)In: Article in journal (Refereed) Submitted
    National Category
    Energy Engineering
    Identifiers
    urn:nbn:se:uu:diva-329835 (URN)
    Available from: 2017-09-21 Created: 2017-09-21 Last updated: 2019-04-01
    3. Marine Current Energy Converters deployments modelling
    Open this publication in new window or tab >>Marine Current Energy Converters deployments modelling
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-380858 (URN)
    Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01
    4. Deployment and Maintenance of Wave Energy Converters at the Lysekil Research Site: A Comparative Study on the Use of Divers and Remotely-Operated Vehicles
    Open this publication in new window or tab >>Deployment and Maintenance of Wave Energy Converters at the Lysekil Research Site: A Comparative Study on the Use of Divers and Remotely-Operated Vehicles
    Show others...
    2018 (English)In: Journal of Marine Science and Engineering, E-ISSN 2077-1312, Vol. 6, no 2, article id 39Article in journal (Refereed) Published
    Abstract [en]

    Ocean renewable technologies have been rapidly developing over the past years. However, current high installation, operation, maintenance, and decommissioning costs are hindering these offshore technologies to reach a commercialization stage. In this paper we focus on the use of divers and remotely-operated vehicles during the installation and monitoring phase of wave energy converters. Methods and results are based on the wave energy converter system developed by Uppsala University, and our experience in offshore deployments obtained during the past eleven years. The complexity of underwater operations, carried out by either divers or remotely-operated vehicles, is emphasized. Three methods for the deployment of wave energy converters are economically and technically analyzed and compared: one using divers alone, a fully-automated approach using remotely-operated vehicles, and an intermediate approach, involving both divers and underwater vehicles. The monitoring of wave energy converters by robots is also studied, both in terms of costs and technical challenges. The results show that choosing an autonomous deployment method is more advantageous than a diver-assisted method in terms of operational time, but that numerous factors prevent the wide application of robotized operations. Technical solutions are presented to enable the use of remotely-operated vehicles instead of divers in ocean renewable technology operations. Economically, it is more efficient to use divers than autonomous vehicles for the deployment of six or fewer wave energy converters. From seven devices, remotely-operated vehicles become advantageous.

    National Category
    Marine Engineering
    Identifiers
    urn:nbn:se:uu:diva-348816 (URN)10.3390/jmse6020039 (DOI)000436558500011 ()
    Funder
    StandUpEU, FP7, Seventh Framework Programme, 607656Swedish Energy Agency
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2019-04-01Bibliographically approved
    5. Risk assessment of deployment of an Uppsala University wave energy converter from a barge in different sea states.
    Open this publication in new window or tab >>Risk assessment of deployment of an Uppsala University wave energy converter from a barge in different sea states.
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-380859 (URN)
    Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01
    6. Offshore Deployment of Point Absorbing Wave Energy Converters with a Direct Driven Linear Generator Power Take-Off at the Lysekil Test Site
    Open this publication in new window or tab >>Offshore Deployment of Point Absorbing Wave Energy Converters with a Direct Driven Linear Generator Power Take-Off at the Lysekil Test Site
    2014 (English)In: 33Rd International Conference On Ocean, Offshore And Arctic Engineering, 2014, Vol 9A: Ocean Renewable Energy, 2014Conference paper, Published paper (Refereed)
    Abstract [en]

    Within the year 2013, four linear generators with point absorber buoy systems were deployed in the Lysekil test site. Until now, deployments of these point absorbing wave energy converters have been expensive, time consuming, complicated and raised safety issues. In the present paper, we focus on the analysis and optimization of the offshore deployment process of wave energy converters with a linear generator power take-off which has been constructed by Uppsala University. To address the crucial issues regarding the deployment difficulties, case study of previous offshore deployments at the Lysekil test site are presented regarding such parameters as safety, cost and time efficiency. It was discovered that the deployment process can be improved significantly, mainly by using new technologies, e.g., new specialized deployment vessels, underwater robots for inspections and for connecting cables and an automatized pressurizing process. Addressing the main deployment difficulties and constrains leads us to discovery of methods that makes offshore deployments more cost-efficient and faster, in a safety context.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering Ocean and River Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-222445 (URN)10.1115/OMAE2014-23396 (DOI)000363499000023 ()978-0-7918-4553-0 (ISBN)
    Conference
    Proceedings of the 33rd International Conference on Ocean, Offshore and Arctic Engineering, ASME 2014
    Available from: 2014-04-11 Created: 2014-04-10 Last updated: 2019-04-01Bibliographically approved
    7. Offshore Deployment of Marine Substation in the Lysekil Research Site
    Open this publication in new window or tab >>Offshore Deployment of Marine Substation in the Lysekil Research Site
    2015 (English)Conference paper, Published paper (Refereed)
    Keywords
    energy conversion; marine substation; offshore deployment; offshore deployment optimization; renewable energy.
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-248539 (URN)
    Conference
    25th International Ocean and Polar Engineering Conference, ISOPE 2015, June 21-26, 2015, Kona, Big Island, Hawaii
    Available from: 2015-03-31 Created: 2015-03-31 Last updated: 2019-04-01
    8. Wave Energy Research at Uppsala University and The Lysekil Research Site, Sweden: A Status Update
    Open this publication in new window or tab >>Wave Energy Research at Uppsala University and The Lysekil Research Site, Sweden: A Status Update
    Show others...
    2015 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    This paper provides a summarized status update ofthe Lysekil wave power project. The Lysekil project is coordinatedby the Div. of Electricity, Uppsala University since 2002, with theobjective to develop full-scale wave power converters (WEC). Theconcept is based on a linear synchronous generator (anchored tothe seabed) driven by a heaving point absorber. This WEC has nogearbox or other mechanical or hydraulic conversion systems,resulting in a simpler and robust power plant. Since 2006, 12 suchWECs have been build and tested at the research site located atthe west coast of Sweden. The last update includes a new andextended project permit, deployment of a new marine substation,tests of several concepts of heaving buoys, grid connection,improved measuring station, improved modelling of wave powerfarms, implementation of remote operated vehicles forunderwater cable connection, and comprehensive environmentalmonitoring studies.

    Keywords
    Wave energy, point absorber, experiments, arrays, generators, ROVs
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering Ocean and River Engineering
    Identifiers
    urn:nbn:se:uu:diva-265218 (URN)
    Conference
    Proceedings of the 11th European Wave and Tidal Energy Conference. Nantes, France, September 2015
    Available from: 2015-10-26 Created: 2015-10-26 Last updated: 2019-04-05Bibliographically approved
    9. Experimental Test of Grid Connected VSC to Improve the Power Quality in a Wave Power System
    Open this publication in new window or tab >>Experimental Test of Grid Connected VSC to Improve the Power Quality in a Wave Power System
    Show others...
    2018 (English)Conference paper, Published paper (Refereed)
    National Category
    Other Electrical Engineering, Electronic Engineering, Information Engineering Meteorology and Atmospheric Sciences
    Identifiers
    urn:nbn:se:uu:diva-361208 (URN)
    Conference
    Fifth International Conference on Electric Power and Energy Conversion Systems (EPECS 2018), Kitakyushu, Japan : April 23-25, 2018
    Available from: 2018-09-21 Created: 2018-09-21 Last updated: 2019-04-01Bibliographically approved
    10. Grid Integration and a Power Quality Assessment of a Wave Energy Park.
    Open this publication in new window or tab >>Grid Integration and a Power Quality Assessment of a Wave Energy Park.
    Show others...
    (English)In: Article in journal (Other academic) Submitted
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-380860 (URN)
    Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01
  • Public defence: 2019-05-17 10:15 Room 2446, Uppsala
    Shrestha, Amendra
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems.
    Techniques for analyzing digital environments from a security perspective2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The development of the Internet and social media has exploded in the last couple of years. Digital environments such as social media and discussion forums provide an effective method of communication and are used by various groups in our societies.  For example, violent extremist groups use social media platforms for recruiting, training, and communicating with their followers, supporters, and donors. Analyzing social media is an important task for law enforcement agencies in order to detect activity and individuals that might pose a threat towards the security of the society.

    In this thesis, a set of different technologies that can be used to analyze digital environments from a security perspective are presented. Due to the nature of the problems that are studied, the research is interdisciplinary, and knowledge from terrorism research, psychology, and computer science are required. The research is divided into three different themes. Each theme summarizes the research that has been done in a specific area.

    The first theme focuses on analyzing digital environments and phenomena. The theme consists of three different studies. The first study is about the possibilities to detect propaganda from the Islamic State on Twitter.  The second study focuses on identifying references to a narrative containing xenophobic and conspiratorial stereotypes in alternative immigration critic media. In the third study, we have defined a set of linguistic features that we view as markers of a radicalization.

    A group consists of a set of individuals, and in some cases, individuals might be a threat towards the security of the society.  The second theme focuses on the risk assessment of individuals based on their written communication. We use different technologies including machine learning to experiment the possibilities to detect potential lone offenders.  Our risk assessment approach is implemented in the tool PRAT (Profile Risk Assessment Tool).

    Internet users have the ability to use different aliases when they communicate since it offers a degree of anonymity. In the third theme, we present a set of techniques that can be used to identify users with multiple aliases. Our research focuses on solving two different problems: author identification and alias matching. The technologies that we use are based on the idea that each author has a fairly unique writing style and that we can construct a writeprint that represents the author. In a similar manner,  we also use information about when a user communicates to create a timeprint. By combining the writeprint and the timeprint, we can obtain a set of powerful features that can be used to identify users with multiple aliases.

    To ensure that the technologies can be used in real scenarios, we have implemented and tested the techniques on data from social media. Several of the results are promising, but more studies are needed to determine how well they work in reality.

    List of papers
    1. A Machine Learning Approach Towards Detecting Extreme Adopters in Digital Communities
    Open this publication in new window or tab >>A Machine Learning Approach Towards Detecting Extreme Adopters in Digital Communities
    2017 (English)In: 2017 28th International Workshop on Database and Expert Systems Applications (DEXA) / [ed] Tjoa, AM Wagner, RR, IEEE, 2017, p. 1-5Conference paper, Published paper (Other academic)
    Abstract [en]

    In this study we try to identify extreme adopters on a discussion forum using machine learning. An extreme adopter is a user that has adopted a high level of a community-specific jargon and therefore can be seen as a user that has a high degree of identification with the community. The dataset that we consider consists of a Swedish xenophobic discussion forum where we use a machine learning approach to identify extreme adopters using a number of linguistic features that are independent on the dataset and the community. The results indicates that it is possible to separate these extreme adopters from the rest of the discussants on the discussion forum with more than 80% accuracy. Since the linguistic features that we use are highly domain independent, the results indicates that there is a possibility to use this kind of techniques to identify extreme adopters within other communities as well.

    Place, publisher, year, edition, pages
    IEEE, 2017
    Series
    International Workshop on Database and Expert Systems Applications-DEXA, ISSN 1529-4188
    Keywords
    Discussion forums, Support vector machines, Pragmatics, Manuals, Radio frequency, Electronic mail, Social network services
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-351187 (URN)10.1109/DEXA.2017.17 (DOI)000426078300001 ()978-1-5386-1051-0 (ISBN)
    Conference
    28th International Workshop on Database and Expert Systems Applications (DEXA), AUG 28-31, 2017, Lyon3 Univ, Lyon, FRANCE
    Available from: 2018-05-23 Created: 2018-05-23 Last updated: 2019-03-22Bibliographically approved
    2. Identifying warning behaviors of violent lone offenders in written communication
    Open this publication in new window or tab >>Identifying warning behaviors of violent lone offenders in written communication
    2016 (English)In: Proc. 16th ICDM Workshops, IEEE Computer Society, 2016, p. 1053-1060Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    IEEE Computer Society, 2016
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-306943 (URN)10.1109/ICDMW.2016.0152 (DOI)978-1-5090-5910-2 (ISBN)
    Conference
    ICDM Workshop on Social Media and Risk, SOMERIS 2016, December 12, Barcelona, Spain
    Available from: 2017-02-02 Created: 2016-11-07 Last updated: 2019-03-22Bibliographically approved
    3. Automatic detection of xenophobic narratives: A case study on Swedish alternative media
    Open this publication in new window or tab >>Automatic detection of xenophobic narratives: A case study on Swedish alternative media
    2016 (English)In: Proc. 14th International Conference on Intelligence and Security Informatics, IEEE, 2016, p. 121-126Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    IEEE, 2016
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-306903 (URN)10.1109/ISI.2016.7745454 (DOI)000390129600021 ()978-1-5090-3865-7 (ISBN)
    Conference
    ISI 2016, September 28–30, Tucson, AZ
    Available from: 2016-11-17 Created: 2016-11-04 Last updated: 2019-03-22Bibliographically approved
    4. Linguistic analysis of lone offender manifestos
    Open this publication in new window or tab >>Linguistic analysis of lone offender manifestos
    2016 (English)In: Proc. 4th International Conference on Cybercrime and Computer Forensics, IEEE, 2016Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    IEEE, 2016
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-306941 (URN)10.1109/ICCCF.2016.7740427 (DOI)000390123800007 ()978-1-5090-6096-2 (ISBN)
    Conference
    ICCCF 2016, June 12–14, Vancouver, Canada
    Available from: 2016-11-17 Created: 2016-11-07 Last updated: 2019-03-22Bibliographically approved
    5. Detecting multipliers of jihadism on twitter
    Open this publication in new window or tab >>Detecting multipliers of jihadism on twitter
    2015 (English)In: Proc. 15th ICDM Workshops, IEEE Computer Society, 2015, p. 954-960Conference paper, Published paper (Refereed)
    Abstract [en]

    Detecting terrorist related content on social media is a problem for law enforcement agency due to the large amount of information that is available. In this paper we describe a first step towards automatically classifying twitter user accounts (tweeps) as supporters of jihadist groups who disseminate propaganda content online. We use a machine learning approach with two set of features: data dependent features and data independent features. The data dependent features are features that are heavily influenced by the specific dataset while the data independent features are independent of the dataset and that can be used on other datasets with similar result. By using this approach we hope that our method can be used as a baseline to classify violent extremist content from different kind of sources since data dependent features from various domains can be added.

    Place, publisher, year, edition, pages
    IEEE Computer Society, 2015
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-272243 (URN)10.1109/ICDMW.2015.9 (DOI)000380556700127 ()9781467384926 (ISBN)
    External cooperation:
    Conference
    ICDM Workshop on Intelligence and Security Informatics, ISI-ICDM 2015, November 14, Atlantic City, NJ
    Available from: 2015-11-14 Created: 2016-01-12 Last updated: 2019-03-22Bibliographically approved
    6. Detecting multiple aliases in social media
    Open this publication in new window or tab >>Detecting multiple aliases in social media
    2013 (English)In: Proc. 5th International Conference on Advances in Social Networks Analysis and Mining, New York: ACM Press, 2013, p. 1004-1011Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    New York: ACM Press, 2013
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-216568 (URN)10.1145/2492517.2500261 (DOI)978-1-4503-2240-9 (ISBN)
    Conference
    ASONAM 2013, August 25-29, Niagara Falls, Canada
    Funder
    Vinnova
    Available from: 2013-08-29 Created: 2014-01-23 Last updated: 2019-03-22Bibliographically approved
    7. Timeprints for identifying social media users with multiple aliases
    Open this publication in new window or tab >>Timeprints for identifying social media users with multiple aliases
    2015 (English)In: Security Informatics, ISSN 2190-8532, Vol. 4, p. 7:1-11, article id 7Article in journal (Refereed) Published
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-272242 (URN)10.1186/s13388-015-0022-z (DOI)
    Available from: 2015-09-24 Created: 2016-01-12 Last updated: 2019-03-22Bibliographically approved
    8. Multi-domain alias matching using machine learning
    Open this publication in new window or tab >>Multi-domain alias matching using machine learning
    2016 (English)In: Proc. 3rd European Network Intelligence Conference, IEEE, 2016, p. 77-84Conference paper, Published paper (Refereed)
    Abstract [en]

    We describe a methodology for linking aliases belonging to the same individual based on a user's writing style (stylometric features extracted from the user generated content) and her time patterns (time-based features extracted from the publishing times of the user generated content). While most previous research on social media identity linkage relies on matching usernames, our methodology can also be used for users who actively try to choose dissimilar usernames when creating their aliases. In our experiments on a discussion forum dataset and a Twitter dataset, we evaluate the performance of three different classifiers. We use the best classifier (AdaBoost) to evaluate how well it works on different datasets using different features. Experiments show that combining stylometric and time based features yield good results on our synthetic datasets and a small-scale evaluation on real-world blog data confirm these results, yielding a precision over 95%. The use of emotion-related and Twitter-related features yield no significant impact on the results.

    Place, publisher, year, edition, pages
    IEEE, 2016
    National Category
    Computer and Information Sciences
    Identifiers
    urn:nbn:se:uu:diva-306944 (URN)10.1109/ENIC.2016.019 (DOI)000399097600011 ()9781509034550 (ISBN)
    Conference
    ENIC 2016, September 5–7, Wroclaw, Poland
    Available from: 2017-02-02 Created: 2016-11-07 Last updated: 2019-03-22Bibliographically approved
    9. Assessment of risk in written communication: Introducing the Profile Risk Assessment Tool (PRAT)
    Open this publication in new window or tab >>Assessment of risk in written communication: Introducing the Profile Risk Assessment Tool (PRAT)
    Show others...
    2018 (English)Report (Other academic)
    Place, publisher, year, edition, pages
    Belgium: EUROPOL, 2018. p. 24
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-367346 (URN)
    Note

    This paper was presented at the 2nd European Counter-Terrorism Centre (ECTC) Advisory Groupconference, 17-18 April 2018, at Europol Headquarters, The Hague.

    Available from: 2018-11-30 Created: 2018-11-30 Last updated: 2019-03-22Bibliographically approved
    10. Linguistic markers of a radicalized mind-set among extreme adopters
    Open this publication in new window or tab >>Linguistic markers of a radicalized mind-set among extreme adopters
    2017 (English)In: Proc. 10th ACM International Conference on Web Search and Data Mining, New York: ACM Press, 2017, p. 823-824Conference paper, Published paper (Refereed)
    Abstract [en]

    The words that we use when communicating in social media can reveal how we relate to ourselves and to others. For instance, within many online communities, the degree of adaptation to a community-specific jargon can serve as a marker of identification with the community. In this paper we single out a group of so called extreme adopters of community-specific jargon from the whole group of users of a Swedish discussion forum devoted to the topics immigration and integration. The forum is characterized by a certain xenophobic jargon, and we hypothesize that extreme adopters of this jargon also exhibit certain linguistic features that we view as markers of a radicalized mind-set. We use a Swedish translation of LIWC (linguistic inquiry word count) and find that the group of extreme adopters differs significantly from the whole group of forum users regarding six out of seven linguistic markers of a radicalized mind-set.

    Place, publisher, year, edition, pages
    New York: ACM Press, 2017
    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:uu:diva-379919 (URN)10.1145/3018661.3022760 (DOI)978-1-4503-4675-7 (ISBN)
    Conference
    WSDM 2017, 1st International Workshop on Cyber Deviance Detection
    Available from: 2017-02-02 Created: 2019-03-21 Last updated: 2019-04-08Bibliographically approved
  • Enander, Lukas
    Implementering och utvärdering av algoritmer för identifiering av läckor från flödesdata2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Uppsala Vatten, which is the water supply provider in Uppsala Municipality, has a leakage of 14 percent in their water distribution network. This amounts to a yearly loss of 2.4 million cubic meters of processed drinking water and 1.8 GWh of wasted energy. Uppsala Vatten has a set goal of lowering the leakage from 14 to 10 percent by 2022. 

    The company has around 40 wireless flow meters and is interested in using data analysis on flow data collected by these to find leaks more rapidly and thus decrease water loss. In this paper five algorithms for change detection were implemented and evaluated for the application of identifying leaks in water flow data.

    Implementation and testing of these algorithms on both real flow data and artificially created data was conducted to determine their suitability for the application and for relative comparison. Successful identification of leaks in real data was achieved for all five algorithms although the performance varied among them.

  • Bergström, Filip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages.
    España e Hispanoamérica - ¿un equilibrio?: Una comparación de tres libros de enseñanza en el Bachillerato sueco2017Independent thesis Basic level (degree of Bachelor), 300 HE creditsStudent thesis
    Abstract [es]

    ¿Qué significa aprender un idioma? Es probable que lo primero que respondamos a esta pregunta sea: “la capacidad de hablar y comunicarse bien, conocer la gramática, tener un vocabulario extenso”, etc., pero una parte imprescindible del proceso de aprendizaje es adquirir conocimientos de las muchas culturas diferentes donde hablan la lengua. En este trabajo presentamos tres materiales didácticos actualmente usados en el bachillerato sueco, y los estudiamos desde la perspectiva de representación y diversidad. Hemos analizado los contenidos de los textos para ver el grado de variedad cultural, así como una investigación de qué dicen los planes de estudios que los libros han de contener. Llegamos a la conclusión de que hay una sobrerrepresentación de España, en comparación con Hispanoamérica, en cuanto al número de países representados del continente ultramar y el espacio de texto que ocupan los diferentes países en los libros de enseñanza, lo cual no solo indica un desequilibrio en la representación de las culturas hispanohablantes, sino también una pérdida en términos de diversidad. 

  • Wallerström, Therese
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Romance Languages.
    "Bandy del flor [...] se puede discutir si es una estrategia exitosa o no": Un estudio sobre las dificultades de los profesores de español en la identificación y la evaluación de las estrategias compensatorias léxicas en la comunicación escrita2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    En el presente trabajo se ha estudiado la problemática que algunos profesores de español en Suecia enfrentan al identificar y evaluar estrategias comunicativas en una prueba escrita por un alumno del nivel A2. Entrevistas cualitativas semiestructuradas han sido llevadas a cabo con seis profesores de seis escuelas suecas con el objetivo de resaltar sus pensamientos y experiencias acerca la identificación y la evaluación de las estrategias compensatorias léxicas en la comunicación escrita. El resultado de las respuestas analizadas destaca ciertos aspectos problemáticos que los informantes enfrentan al identificar y evaluar las estrategias que pueden resultar en una diferencia evaluativa a nivel nacional y afectar el principio de equidad establecido en la ley escolar sueca.

  • Coleman, Itai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Personuppgifter, anonymisering och pseudonymisering: En kritisk analys av begreppsbildningen i GDPR2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Sarah, Nordström
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Skyddsregeln vid brusten anknytning: En analys av förutsättningarna för enhetlig och ändamålsenlig tillämpning av 5 kap. 16 § 3 st. 2 p. UtlL2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Eker, Nicole
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Pettersson, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Omvårdnadsåtgärder för att minska procedursmärta hos spädbarn: En litteraturstudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    ABSTRACT

    Background:Infants are exposed to several medical technical procedures that can cause procedural pain. To ensure that infants do not experience procedural pain, it is required to find nursing methods that can reduce this type of pain. Nursing methods that prevent and reduce procedural pain in infants can be pharmacological and non-pharmacological. Procedural pain in infants leads to infants suffering from disease, which should be avoided.

    Aim:The aim of this literature study is to chart if preventive pharmacological and non-pharmacological nursing methods can reduce procedural pain in infants during medical technical procedures.

    Method:To answer the aim of the study, a literature study with 11 quantitative articles were conducted. 

    Result:The pharmacological methods that reduce procedural pain in infants are sucrose and glucose while paracetamol is a method that is not effective. The non-pharmacological methods that reduce procedural pain are for example breastfeeding, familiar auditory stimulus and swaddling. Swaddling was also effective in combination with sucrose and non-nutritive sucking while non-nutritive sucking had an preventing effect in combination with oral breastmilk and facilitated tucking. Skin-to-skin contact reduces procedural pain both alone and in combination with breastfeeding. There is no evidence that classical music reduces procedural pain in infants.

    Conclusion:There is evidence that pharmacological and non-pharmacological nursing methods reduce procedural pain in infants during medical technical procedures. Comfortability, physical contact and closeness are important factors in the prevention of pain in infants and can be achieved by use of various non-pharmacological methods. Although the use of pain prevention nursing methods reduces procedural pain, the absence of pain and suffering from disease can not be ensured.

  • Thoms, Ebba
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Är staten en eller flera?: Fråga om avtal mellan statliga myndigheter måste upphandlas2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Köpsell, Stephanie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Trovärdighetsbedömningar och sexuell läggning: Metoder för att fastställa sexuell läggning och rätten till värdighet, integritet och privatliv i asylärenden2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Andersson, Emma
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Nylén, Melina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Anhörigas upplevelser av att vårda en närstående med demenssjukdom: En litteraturstudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background:As the life expectancy of the population increases, more people are diagnosed with dementia. The diagnosis causes a lack of self-care for the affected person, which can result in a relative taking up the role of caregiver. Thus, the quality of life of the relatives may deteriorate when their own needs are disregarded. Relatives support is important in everyday life. Aim: The aim of the study was to investigate family caregivers experiences of caring for a relative with dementia. Method:A literature review based on 13 qualitative articles, selected on the basis of inclusion criteria. Results: After compiling 13 scientific articles, four themes emerged; the life situation gets a turnaround, the disease changed everyday life, the caregiver's experience of health and the importance of knowledge and support for a good care.The caregiver experienced the changed life situation demanding. New roles as well as changing family relationships caused difficulties in life. The dementia disease caused personality changes that forced the relative to adapt the everyday life to the relative. The physical and mental health of the caregiver was adversely affected by the situation. Relatives felt that feelings of anxiety dominated over the loved one and in the thoughts of the future. Lack of information and knowledge caused difficulties in the care of the dementia patient. The importance of support in everyday life emerged. Conclusion: The life situation changes and life forces adaptation after dementia. Formal support is significant in everyday life. Relatives experience psychological and physical illness. Lack of knowledge and information can be an important cause of perceived bad health, access to support should be facilitated.

  • Larsson, Tove
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of English.
    Review of Ditte Kimps. Tag questions in conversation: A typology of their interactional and stance meanings. Amsterdam/