uu.seUppsala universitets publikasjoner
1234567 1 - 50 of 483
rss atomLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
  • Rodin, Sergey
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden.
    Rebellato, Paola
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Lundin, Arne
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Zubarev, Roman A.
    Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden;IM Sechenov First Moscow State Med Univ, Dept Pharmacol & Technol Chem, Moscow, Russia.
    Isotopic resonance at 370 ppm deuterium negatively affects kinetics of luciferin oxidation by luciferase2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 16249Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Since 1930s, it has been known that some biochemical and biological processes exhibit abnormal kinetics at a deuterium concentration in the local environment of 250-600 ppm, which is 2-4 times higher that the normal concentration of 150 ppm D. We sought to test if the kinetics of firefly luciferase oxidizing luciferin, the reaction widely used as a read-out in various biochemical assays, is also affected by an elevated deuterium content. To this end, both luciferase and luciferin substrate solutions were prepared based on water with extra deuterium added to a concentration ranging from 150 ppm and up to 10,000 ppm (1%). Upon mixing the solutions, the luminescence intensity at different times was compared with that of the corresponding control solutions with 150 ppm D. A broad negative resonance was detected (p < 10(-6)), with a approximate to 20% drop in luminescence at 370 ppm D. Given that, on average, about half of hydrogen atoms in proteins are not exchangeable in solution, this value corresponds to approximate to 260 ppm of deuterium in all enzyme's hydrogens, in a very good agreement with the prediction of the Isotopic resonance hypothesis.

  • Karademir, Betul
    et al.
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey.
    Sari, Gulce
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey;Okan Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey.
    Jannuzzi, Ayse Tarbin
    Istanbul Univ, Fac Pharm, Dept Pharmaceut Toxicol, Istanbul, Turkey.
    Musunuri, Sravani
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Wicher, Grzegorz
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Neuroonkologi.
    Grune, Tilman
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Mi, Jia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China.
    Hacioglu-Bay, Husniye
    Marmara Univ, Sch Med, Dept Anat, Istanbul, Turkey.
    Forsberg-Nilsson, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Neuroonkologi.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Jung, Tobias
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 16318Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical applications. However neuropathic side effects are dose limiting for BTZ as many other chemotherapeutic agents. Therefore second-generation proteasome inhibitors have been developed including carfilzomib (CFZ). Aim of the present work was investigating the mechanisms of peripheral neuropathy triggered by the proteasome inhibitor BTZ and comparing the pathways affected by BTZ and CFZ, respectively. Neural stem cells, isolated from the cortex of E14 mouse embryos, were treated with BTZ and CFZ and mass spectrometry was used to compare the global protein pool of treated cells. BTZ was shown to cause more severe cytoskeletal damage, which is crucial in neural cell integrity. Excessive protein carbonylation and actin filament destabilization were also detected following BTZ treatment that was lower following CFZ treatment. Our data on cytoskeletal proteins, chaperone system, and protein oxidation may explain the milder neurotoxic effects of CFZ in clinical applications.

  • Albaalbaky, Ahmed
    et al.
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Kvashnin, Yaroslav
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Patte, Renaud
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Fresard, Raymond
    Normandie Univ, CRISMAT, CNRS, UNICAEN,ENSICAEN, F-14050 Caen, France.
    Ledue, Denis
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Effects of Ga doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2: Ab initio and Monte Carlo approaches2018Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, nr 17, artikkel-id 174403Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The effects of nonmagnetic impurity doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2 are investigated by means of density functional theory calculations and Monte Carlo simulations. Density functional theory calculations show that replacing up to 30% of Cr3+ ions by Ga3+ ones does not significantly affect the remaining Cr-Cr superexchange interactions. Monte Carlo simulations show that CuCr1-xGaxO2 preserves its magnetoelectric properties up to x similar or equal to 0.15 with a spiral ordering, while it becomes disordered at higher fractions. Antiferromagnetic transition shifts towards lower temperatures with increasing x and eventually disappears at x >= 0.2. Our simulations show that Ga3+ doping increases the Curie-Weiss temperature of CuCr1-xGaxO2, which agrees well with experimental observations. Moreover, our results show that the incommensurate ground-state configuration is destabilized by Ga3+ doping under zero applied field associated with an increase of frustration. Finally, coupling between noncollinear magnetic ordering and electric field is reported for x <= 0.15 through simulating P-E hysteresis loops, which leads to ferroelectricity in the extended inverse Dzyaloshinskii-Moriya model.

  • Gao, Tianle
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China.
    Ma, Haisha
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Genetisk utvecklingsbiologi.
    Xu, Bo
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Bergman, Jessica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Larhammar, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Farmakologi.
    Lagerström, Malin C.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Genetisk utvecklingsbiologi.
    The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch2018Inngår i: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 138, nr 11, s. 2405-2411Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y-1 receptor system on scratch behavior in mice. We found that intrathecal administration of the Y-1 agonist [Leu(31), Pro(34)]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck compared with saline treatment, indicating that activation of the spinal NPY/Y-1 system dampens mechanical itch. However, intrathecal administration of LP-NPY also attenuated chemically induced scratching provoked by intradermal application of histamine or the mast cell degranulator 48/80 (histaminergic itch), and the latter effect could be reversed by administration of the Y-1 antagonist BIBO3304. Intrathecal application of the native nonselective agonist NPY also attenuated histamine or 48/80-induced scratching. Our analyses emphasize the importance of including additional quantitative parameters to characterize the full spectrum of itch behavior and show that the NPY/Y-1 system dampens both mechanically and chemically induced scratching and hence is shared by the two submodalities of itch.

  • Pincini, D.
    et al.
    UCL, London Ctr Nanotechnol, Gower St, London WC1E 6BT, England;UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England;Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Fabrizi, F.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Beutier, G.
    Univ Grenoble Alpes, CNRS, Grenoble INP, SIMaP, F-38000 Grenoble, France.
    Nisbet, G.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Elnaggar, H.
    Univ Utrecht, Debye Inst Nanomat Sci, Univ Weg 99, NL-3584 CG Utrecht, Netherlands.
    Dmitrienko, V. E.
    AV Shubnikov Inst Crystallog, FSRC Crystallog & Photon RAS, Moscow 119333, Russia.
    Katsnelson, M. , I
    Kvashnin, Yaroslav
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Lichtenstein, A. , I
    Mazurenko, V. V.
    Ural Fed Univ, Dept Theoret Phys & Appl Math, Mira Str 19, Ekaterinburg 620002, Russia.
    Ovchinnikova, E. N.
    Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119991, Russia.
    Dimitrova, O. , V
    Collins, S. P.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Role of the orbital moment in a series of isostructural weak ferromagnets2018Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, nr 10, artikkel-id 104424Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The orbital contribution to the magnetic moment of the transition-metal ion in the isostructural weak ferromagnets ACO(3) (A = Mn,Co,Ni) and FeBO3 was investigated by a combination of first-principles calculations, nonresonant x-ray magnetic scattering, and x-ray magnetic circular dichroism. A nontrivial evolution of the orbital moment as a function of the 3d orbitals filling is revealed, with a particularly large value found in the Co member of the family. Here, the coupling between magnetic and lattice degrees of freedom produced by the spin-orbit interaction results in a large single-ion anisotropy and a peculiar magnetic-moment-induced electron cloud distortion, evidenced by the appearance of a subtle scattering amplitude at space-group-forbidden reflections and significant magnetostrictive effects. Our results, which complement a previous investigation on the sign of the Dzyaloshinskii-Moriya interaction across the series, highlight the importance of spin-orbit coupling in the physics of weak ferromagnets and prove the ability of modern first-principles calculations to predict the properties of materials where the Dzyaloshinskii-Moriya interaction is a fundamental ingredient of the magnetic Hamiltonian.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zur Nedden, M.
    Prompt and non-prompt J/psi and psi(2S) suppression at high transverse momentum in 5.02 TeV Pb+Pb collisions with the ATLAS experiment2018Inngår i: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, nr 9, artikkel-id 762Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A measurement of J/psi and psi(2S) production is presented. It is based on a data sample from Pb+Pb collisions at root s(NN) = 5.02 TeV and pp collisions at root s = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of 0.42 nb(-1) and 25 pb(-1) in Pb+Pb and pp, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for 9 < p(T)(mu mu) < 40 GeV in dimuon transverse momentum, and -2 < y(mu mu) < 2 in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt J/psi, increasing with event centrality. The suppression of prompt psi(2S) is observed to be stronger than that of J/psi, while the suppression of non-prompt psi(2S) is equal to that of the non-prompt J/psi within uncertainties, consistent with the expectation that both arise from b-quarks propagating through the medium. Despite prompt and non-prompt J/psi arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar.

  • Norström, Elin
    et al.
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden.
    Noren, Gabriel
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden;Univ Cologne, Inst Geol & Mineral, D-50923 Cologne, Germany.
    Smittenberg, Rienk H.
    Stockholm Univ, Dept Geol Sci, S-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, S-10691 Stockholm, Sweden.
    Massuanganhe, Elidio A.
    Univ Eduardo Mondlane, Dept Geol, CP 257, Maputo, Mozambique.
    Ekblom, Anneli
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för arkeologi och antik historia, Arkeologi.
    Leaf wax delta D inferring variable medieval hydroclimate and early initiation of Little Ice Age (LIA) dryness in southern Mozambique2018Inngår i: Global and Planetary Change, ISSN 0921-8181, E-ISSN 1872-6364, Vol. 170, s. 221-233Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A sediment sequence from a coastal, hydrologically isolated lake in southern Mozambique was analysed for leaf wax delta D, n-alkane abundance (ACL) and bulk organic geochemistry (delta C-13, TOC, %N), providing a record of past rainfall variability and savanna dynamics over the last 1500 years. The delta D-wax a rainfall reconstruction reveals a stable hydroclimate between 500-700 CE, while ACL and delta C-13 together with previous pollen data suggest savanna vegetation was characterized by a relatively dense woody cover. Highly variable hydroclimate conditions are inferred by delta D-wax between 800-1350 CE, with repeated centennial scale intervals of extreme dry and wet conditions overlapping the Medieval Climate Anomaly (MCA; 950-1250 CE). Savanna tree cover stayed relatively intact over this phase. After ca 1250 CE, a progressive change towards drier conditions was initiated, leading up to maximum aridity during the AD 1700s, a period associated with the Little Ice age (LIA; 1500-1850 CE). Tree cover was now replaced by a more grass-dominated savanna. The clear antiphase rainfall patterns between Nhaucati and equatorial East African proxy records gives support to the notion that Indian Ocean sea surface temperature (SST) gradients act as modulator of southern African climate on a multi-decadal time scale, possibly forced by long-term El Nino Southern Oscillation (ENSO) variability. We suggest that strong ENSO variability and greater occurrence of La Nina events triggered the generally wet and unstable MCA in southern Africa. From around 1250 CE, a shift towards a predominance of El Nino induced drier conditions in south-east Africa during the LIA. Our study of vegetation and hydroclimate proxies in parallel suggests that savanna tree and shrub cover was relatively resilient to the abrupt shifts in hydroclimate over the MCA, but more sensitive to the long-term progressive drying over the LIA.

  • Perotti, Elisabetta
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Kärnfysik.
    Extraction of Polarization Parameters in the ‾pp → Ω̄Ω Reaction2018Inngår i: FAIRNESS 2017: Fair Next Generation Scientists 2017, 2018, artikkel-id UNSP 012019Konferansepaper (Fagfellevurdert)
    Abstract [en]

    A method to extract the polarization of Omega hyperons produced via the strong interaction is presented. Assuming they are spin 3/2 particles, the corresponding spin density matrix can be written in terms of seven non-zero polarization parameters, all retrievable from the angular distribution of the decay products. Moreover by considering the full decay chain Omega ->Lambda K -> p pi K the magnitude of the asymmetry parameters beta Omega and gamma Omega can be obtained. This method, applied here to the specific Omega case, can be generalized to any weakly decaying hyperon and is perfectly suited for the PANDA experiment where hyperon-antihyperon pairs will be copiously produced in proton-antiproton collisions. The aim is to take a step forward towards the understanding of the mechanism that reigns strangeness production in these processes.

  • Wallin, Adéle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Elektricitetslära.
    Structural intrusion, flow disturbance and spillway capacity: CFD modeling of the Torpshammar dam2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    At the Torpshammar dam two rectangular beams are situated upstream of the spillway gates to stabilize the sidewalls holding the embankment of the dam. A computational fluid dynamics (CFD) simulation of the dam with the bottom outlets open was made to investigate how the flow and discharge capacity is affected by the beams. The results can be used to avoid unexpected consequences due to turbulence caused by the beams, make the beams strong enough to hold the pressure from the flow and get an estimation of the discharge capacity with the beams. Turbulence is one of the hardest things to simulate so the results were compared with previous simulation work made without the beams and physical model tests to validate the results. Also, a sensitivity analysis was made to investigate the method used.

    The beams lowered the velocity (to 17 m/s) and the discharge capacity (to 255 m3/s) compared to the previous work. The force on the beams was directed upward and downstream. The beams increased the turbulence and the vortex shedding frequency was higher for the beam closest to the outlet. The velocity and discharge capacity differed with 6 % compared to model test results. The results can therefore only be used as an estimation, a more detailed computational model and more computational cells are needed to get a better result. The sensitivity analysis showed that the velocity and turbulence depend on the method and further studies need to be made to decide which method gives the closest similarity with reality.

  • Löfberg, My
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Tillämpad kärnfysik.
    Förståelse för värmestrålning: En kvalitativ intervjustudie som undersöker om en laboration på universitetsnivå ökar förståelsen för relationen mellan fenomenen inom värmestrålning.2018Independent thesis Advanced level (degree of Master (Two Years)), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Värmestrålning är ett fenomen som studenter har svårt att förstå Studentsframing. Med detta som bakgrund utformades laborationen Förståelse för värmestrålning våren 2017 med målet att ge studenterna som utförde den en bättre förståelse för relationen mellan de fyra fenomenen inom värmestrålning, absorption, emission, reflektion och transmission. Laborationen delades in i två olika experiment som fokuserade på olika fenomen.Syftet med denna studie är att genom kvalitativa halvstrukturerade samtalsintervjuer undersöka om laborationen ger studenterna en bättre förståelse för relationen mellan dessa fyra fenomen inom värmestrålning. Urvalet till studien var tredjeårsstudenter vid Uppsala universitet vilka läste programmet Teknisk fysik och som vid utförandet av studien just påbörjat kursen Teknisk termodynamik där laborationen ingick.Resultatet visade dels att studenterna själva upplevde en förbättrad förståelse för värmestrålning. Dels indikationer på att förberedelserna inför laborationen och förståelse för den värmekamera som användes under laborationen var viktiga för att studenterna skulle ha möjlighet att förstå och förklara sina resultat korrekt. Studenterna reflekterade inte över om deras förklaringar av laborationens resultat var rimliga eller inte och de jämförde aldrig förklaringarna av respektive experiment med varandra. Urvalet, dvs. studenter med cirka tre års erfarenhet av fysikstudier, tycks inte ha spelat en avgörande roll för hur pass mycket studenterna förstod eller kunde förklara sina resultat.

  • Karlsson, Olov
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Tidén, Tobias
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Påverkas vardagslivet av kontinuerlig glukosmätare: Att vara vårdnadshavare till ett barn med typ 1 diabetes2018Independent thesis Advanced level (degree of Master (One Year)), 10 poäng / 15 hpOppgave
  • Henriksson, Göran
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik.
    King David's Altar in Jerusalem Dated by the Bright Appearance of Comet Encke in 964 BC2018Inngår i: Annals of Archaeology, Vol. 1, nr 1, s. 30-37Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    At the time corresponding to our end of May and beginning of June in 964 BC a bright comet with a very long tail dominated the night sky of the northern hemisphere. It was Comet Encke that was very bright during the Bronze Age, but today it is scarcely visible to the naked eye. It first appeared as a small comet close to the zenith, but for every night it became greater and brighter and moved slowly to the north with its tail pointing southwards. In the first week of June the tail was stretched out across the whole sky and at midnight it was visible close to the meridian. In this paper the author wishes to test the hypothesis that this appearance of Comet Encke corresponds to the motion in the sky above Jerusalem of “the sword of the Angel of the Lord”, mentioned in 1 Chronicles, in the Old Testament. Encke was first circumpolar and finally set at the northern horizon on 8 June in 964 BC at 22. This happened according to the historical chronology between 965 and 960 BC. The calculations of the orbit of Comet Encke have been performed by a computer program developed by the author. It has been calibrated from depictions on Swedish rock-carvings, Chinese texts and Sumerian cylinder seals and gives useful results at least back to 2654 BC.

  • Johnsson, Kajsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Icke farmakologiska behandlingsmetoder vid depression under graviditet: En systematisk litteraturöversikt2018Independent thesis Advanced level (degree of Master (One Year)), 10 poäng / 15 hpOppgave
    Abstract [sv]

    SAMMANFATTNING 

    Bakgrund 

    Depression är vanligt bland unga kvinnor i fertil ålder vilket innebär att barnafödande infaller under en del av livet då många kvinnor är psykisk sårbara. Cirka 10 till 20 procent av alla gravida kvinnor drabbas av depression av varierande grad under den antenatala perioden. Depression ökar risken för tillväxthämning hos fostret, prematur förlossning och postpartum-depression samt försvårar anknytningen mellan mor och barn. Den rådande uppfattningen är att kvinnor som medicinerat med antidepressiva läkemedel innan graviditet bör fortsätta medicinera samt att insättning bör göras när behov finns. Många kvinnor vill dock inte använda antidepressiva läkemedel under graviditet av rädsla för negativ påverkan på fostret och för dessa kvinnor behövs alternativ. I barnmorskans arbete ingår att stödja och vårda kvinnor under graviditet varför kunskap om behandlingsalternativ är vikt för yrkesgruppen. 

    Syfte

    Syftet med detta examensarbete var att undersöka vilka icke-farmakologiska behandlingar som finns för depression under graviditet samt dess för- och nackdelar.

    Metod 

    En systematisk litteraturstudie har gjorts där 28 artiklar inkluderades av totalt 659 granskade titlar, 110 granskade abstracts och 44 artiklar granskade i sin helhet. De inkluderade artiklarna analyserades med kvalitativ innehållsanalys och kvalitetsgranskades i enlighet med Willman, Stoltz och Bahtsevani, (2016).

    Resultat 

    Analysen av studiernas resultat visade attmånga former av ickefarmakologisk behandling kan ha mildrande eller botande effekt vid depression under graviditet. Det framkommer att behandling med yoga, behandling med mind-body terapibehandling given till par, behandling given digitalt, behandling given i grupp samt behandling med psykoterapi eller samtalsstöd har positiv effekt om än i olika grad.Resultatet ger stöd för att komplement till basprogrammet vid sedvanlig mödrahälsovård är eftersträvansvärt och hjälper kvinnor med antenatal depression och att den positiva effekten ofta kvarstår efter förlossningen.

    Slutsats 

    Detta examensarbete visade att många icke-farmakologiska behandlingsmetoder kan hjälpa kvinnor med antenatal depression. Tilltron till behandlingsmetoderna var oftast hög och få negativa effekter framkom. Kvinnor kan utifrån detta informeras om att forskning visat att utöver antidepressiv medicinering finns icke-farmakologiska behandlingsmetoder med god effekt på depression under graviditet. Vidare forskning får visa om behandlingsformerna skulle kunna erbjudas inom ramen för mödrahälsovårdens basprogram, samt om det är möjligt att genom dessa alternativa terapier minska graviditetskomplikationer orsakade av depression.

    NYCKELORD 

    Antenatal depression, behandling, depression, graviditet, moderskap, perinatal terapi

  • Hawkes, Jeffrey A.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Patriarca, Claudia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Sjöberg, Per J. R.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Tranvik, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Extreme isomeric complexity of dissolved organic matter found across aquatic environments2018Inngår i: Limnology and Oceanography Letters, E-ISSN 2378-2242, Vol. 3, s. 21-30Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The natural aquatic environment contains an enormous pool of dissolved reduced carbon, present as ultra- complex mixtures that are constituted by an unknown number of compounds at vanishingly small concentrations. We attempted to separate individual structural isomers from several samples using online reversedphase chromatography with selected ion monitoring/tandem mass spectrometry, but found that isomeric complexity still presented a boundary to investigation even after chromatographic simplification of the samples. However, it was possible to determine that the structural complexity differed among samples. Our results also suggest that extreme structural complexity was a ubiquitous feature of dissolved organic matter (DOM) in all aquatic systems, meaning that this diversity may play similar roles for recalcitrance and degradation of DOM in all tested environments.

  • Bravo, Andrea Garcia
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. bDepartment of Marine Biology and Oceanography, Institut de Ciències del Mar, Consejo Superior de Investigaciones Científicas, Barcelona, Catalonia, Spain.
    Peura, Sari
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Buck, Moritz
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Osman, Omneya
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mateos-Rivera, Alejandro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Herrero Ortega, Sonia
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Schaefer, Jeffra K.
    Bouchet, Sylvain
    Tolu, Julie
    Björn, Erik
    Bertilsson, Stefan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Methanogens and Iron-Reducing Bacteria: the Overlooked Members of Mercury-Methylating Microbial Communities in Boreal Lakes2018Inngår i: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 84, nr 23, s. 1-16, artikkel-id e01774-18Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Methylmercury is a potent human neurotoxin which biomagnifies in aquatic food webs. Although anaerobic microorganisms containing the hgcA gene potentially mediate the formation of methylmercury in natural environments, the di- versity of these mercury-methylating microbial communities remains largely unex- plored. Previous studies have implicated sulfate-reducing bacteria as the main mer- cury methylators in aquatic ecosystems. In the present study, we characterized the diversity of mercury-methylating microbial communities of boreal lake sediments us- ing high-throughput sequencing of 16S rRNA and hgcA genes. Our results show that in the lake sediments, Methanomicrobiales and Geobacteraceae also represent abun- dant members of the mercury-methylating communities. In fact, incubation experi- ments with a mercury isotopic tracer and molybdate revealed that only between 38% and 45% of mercury methylation was attributed to sulfate reduction. These re- sults suggest that methanogens and iron-reducing bacteria may contribute to more than half of the mercury methylation in boreal lakes.

  • Bravo, Andrea Garcia
    et al.
    Kothawala, Dolly
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Attermeyer, Katrin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Tessier, Emmanuel
    Bodmer, Pascal
    Amouroux, David
    Cleaning and sampling protocol for analysis of mercury and dissolved organic matter in freshwater systems2018Inngår i: MethodsX, ISSN 1258-780X, E-ISSN 2215-0161, Vol. 5, s. 1017-1026Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Mercury (Hg), and in particular its methylated form (methylmercury, MeHg), is a hazardous substance with the potential to produce significant adverse neurological and other health effects. Enhanced anthropogenic emissions and long-range transport of atmospheric Hg have increased Hg concentrations above background levels in aquatic systems. In this context, the Minamata Convention, a global legally binding agreement that seeks to prevent human exposure to Hg, was signed and enforced by 128 countries, and today more than 90 Parties have ratified it. All these Parties have committed to develop Hg monitoring programs to report the effectiveness of the convention. For this purpose, we provide a standardized cleaning and water sampling protocol for the determination of total-Hg and MeHg in freshwaters at ambient levels. As Hg and organic matter are tightly bound, the protocol also describes sample collection for dissolved organic carbon (DOC) concentration and characterization of dissolved organic matter (DOM) composition by fluorescence spectroscopy. This protocol is highly useful to non-experts without a prior background in Hg sampling and analysis, and can serve as a useful basis for national monitoring programs. Furthermore, this protocol should help increase quantitative inventories of DOC, inorganic-Hg (IHg) and MeHg concentrations and DOM composition in freshwater, which are severely lacking at a global scale. • Provides a standardized method to collect water samples for IHg, MeHg, DOC and DOM composition from freshwater ecosystems.

  • Shen, Dandan
    et al.
    Leibniz Inst Balt Sea Res, Sect Biol Oceanog, Warnemunde, Germany.
    Langenheder, Silke
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi.
    Juergens, Klaus
    Leibniz Inst Balt Sea Res, Sect Biol Oceanog, Warnemunde, Germany.
    Dispersal Modifies the Diversity and Composition of Active Bacterial Communities in Response to a Salinity Disturbance2018Inngår i: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, artikkel-id 2188Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dispersal can influence the response of bacterial communities to environmental changes and disturbances. However, the extent to which dispersal contributes to the community response in dependence of the character and strength of the disturbance remains unclear. Here, we conducted a transplant experiment using dialysis bags in which bacterioplankton originating from brackish and marine regions of the Saint Lawrence Estuary were reciprocally incubated in the two environments for 5 days. Dispersal treatments were set-up by subjecting half of the microcosms in each environment to an exchange of cells between the marine and brackish assemblages at a daily exchange rate of 6% (v/v), and the other half of microcosms were kept as the nondispersal treatments. Bacterial 16S rRNA sequencing was then used to examine the diversity and composition of the active communities. Alpha diversity of the marine communities that were exposed to the brackish environment was elevated greatly by dispersal, but declined in the absence of dispersal. This indicates that dispersal compensated the loss of diversity in the marine communities after a disturbance by introducing bacterial taxa that were able to thrive and coexist with the remaining community members under brackish conditions. On the contrary, alpha diversity of the brackish communities was not affected by dispersal in either environment. Furthermore, dispersal led to an increase in similarity between marine and brackish communities in both of the environments, with a greater similarity when the communities were incubated in the brackish environment. These results suggest that the higher initial diversity in the brackish than in the marine starting community made the resident community less susceptible to dispersing bacteria. Altogether, this study shows that dispersal modifies the diversity and composition of the active communities in response to a salinity disturbance, and enables the local adjustment of specific bacteria under brackish environmental conditions.

  • Reimer, C.
    et al.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Rubin, Carl-Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Sharifi, A. R.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Ha, N. -T
    Weigend, S.
    Friedrich Loeffler Inst, Inst Farm Anim Genet, Holtystr 10, D-31535 Neustadt, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Waldmann, K. -H
    Distl, O.
    Univ Vet Med Fdn, Inst Anim Breeding & Genet, Bunteweg 17p, D-30559 Hannover, Germany.
    Pant, S. D.
    Charles Sturt Univ, Sch Anim & Vet Sci, Graham Ctr Agr Innovat, Locked Bag 588,Boorooma St, Wagga Wagga, NSW, Australia.
    Fredholm, M.
    Univ Copenhagen, Dept Vet & Anim Sci, Gronnegardsvej 3, DK-1870 Frederiksberg C, Denmark.
    Schlather, M.
    Univ Mannheim, Sch Business Informat & Math, A5 6, D-68131 Mannheim, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Simianer, H.
    Univ Goettingen, Dept Anim Sci, Anim Breeding & Genet Grp, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany;Univ Goettingen, Ctr Integrated Breeding Res, Albrecht Thaer Weg 3, D-37075 Gottingen, Germany.
    Analysis of porcine body size variation using re-sequencing data of miniature and large pigs2018Inngår i: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 19, artikkel-id 687Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Domestication has led to substantial phenotypic and genetic variation in domestic animals. In pigs, the size of so called minipigs differs by one order of magnitude compared to breeds of large body size. We used biallelic SNPs identified from re-sequencing data to compare various publicly available wild and domestic populations against two minipig breeds to gain better understanding of the genetic background of the extensive body size variation. We combined two complementary measures, expected heterozygosity and the composite likelihood ratio test implemented in "SweepFinder", to identify signatures of selection in Minipigs. We intersected these sweep regions with a measure of differentiation, namely F-ST, to remove regions of low variation across pigs. An extraordinary large sweep between 52 and 61 Mb on chromosome X was separately analyzed based on SNP-array data of F-2 individuals from a cross of Goettingen Minipigs and large pigs. Results: Selective sweep analysis identified putative sweep regions for growth and subsequent gene annotation provided a comprehensive set of putative candidate genes. A long swept haplotype on chromosome X, descending from the Goettingen Minipig founders was associated with a reduction of adult body length by 3% in F-2 cross-breds. Conclusion: The resulting set of genes in putative sweep regions implies that the genetic background of body size variation in pigs is polygenic rather than mono-or oligogenic. Identified genes suggest alterations in metabolic functions and a possible insulin resistance to contribute to miniaturization. A size QTL located within the sweep on chromosome X, with an estimated effect of 3% on body length, is comparable to the largest known in pigs or other species. The androgen receptor AR, previously known to influence pig performance and carcass traits, is the most obvious potential candidate gene within this region.

  • Sundblad, Arvid
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Elektricitetslära.
    Identifieringsmöjligheter av feljusterad bussdörr: - Studie av möjliga signalanalyser av dörrpositioner för att finna dörrar som kan orsaka problem2018Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [en]

    In the bus industry, it is well-known that bus doors often cause buses to stand at a stop after either a door could not be opened or closed. This causes huge costs for the bus owner. Therefore, it is desirable to be able to predict whether a door's behaviour begins to become too close to causing such an event. Based on this background, this study has been completed at Scania CV AB in Södertälje in order to find out which signals from a door system that can be used to determine if a door is at risk of failing. The main problems that this study is based on are: - Which existing sensors can be used to measure the most common errors before causing a bus that cannot drive? - Is it possible to find a model that can indicate how to adjust speed and attenuation to get a "perfect" adjusted door? These questions were studied by making measurements on a Scania City Wide bus with double inswing door leafs where measurements were made only on the rear door leaf and for its closing behaviour. To make measurements on the door an oscilloscope was used which measured the voltage across a potentiometer with a voltage that varied depending on how open the door was. Another measurement was made on the embedded control system in the bus body. The noise-corrupted measurement data was filtered with a simple type of filter, called moving average filter. In order to find different methods that predict if there were any errors on the door's settings or components, curves were examined over the doors' position during a closing event. One thing that was studied was which position value that was present when the door couldn’t get closed more. Another thing was the curve's slope in different segments of the closing. The slope of the curve was calculated by using the least squares method, which is a mathematical method in linear algebra. Based on the slope in some curve segments of a closing event, a model was created that could guess the door closing time as well as the damping. This model functioned in a convincing way for measurements from the test bus that was used when developing the model. Other models that the study resulted in was one that could warn if the potentiometer values began to approach a limit when the door could no longer be closed, as well as a model that calculated the closing and opening times of the door. Through these models, the idea was that a warning signal could be sent to a system that warned that the door should be adjusted. When some measurements for the guess model were made on another bus, it gave indications that the model did not work as well as the test bus. But one conclusion that could be drawn was that there was an indication that the door was misaligned, even though the model guessed wrong for the present settings. Another conclusion was that it is likely possible to proceed further with some research on this model to find a new model that is somewhat more general for all individual bus doors.

  • Dimberg, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Vaskulärbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Osteoglycin - A switch from angiogenesis to T-cell recruitment?2018Inngår i: EBioMedicine, E-ISSN 2352-3964, Vol. 35, s. 22-23Artikkel i tidsskrift (Annet vitenskapelig)
  • Howner, Katarina
    et al.
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Natl Board Forens Med, Div Forens Psychiat Stockholm, Dept Forens Psychiat, Stockholm, Sweden.
    Andine, Peter
    Natl Board Forens Med, Div Forens Psychiat Gothenburg, Dept Forens Psychiat, Gothenburg, Sweden; Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad,Ctr Eth Law & Mental Hlth, Gothenburg, Sweden; Sahlgrens Univ Hosp, Forens Psychiat Clin, Gothenburg, Sweden.
    Bertilsson, Goran
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Hultcrantz, Monica
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Lindström, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
    Mowafi, Frida
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Snellman, Alexandra
    Swedish Agcy Hlth Technol Assessment & Assessment, Stockholm, Sweden.
    Hofvander, Bjorn
    Lund Univ, Dept Clin Sci Lund Child & Adolescent Psychiat, Lund, Sweden.
    Mapping Systematic Reviews on Forensic Psychiatric Care: A Systematic Review Identifying Knowledge Gaps2018Inngår i: Frontiers in Psychiatry, ISSN 1664-0640, E-ISSN 1664-0640, Vol. 9, artikkel-id 452Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background: Forensic psychiatric care treats mentally disordered offenders who suffer mainly from psychotic disorders, although comorbidities such as personality disorders, neurodevelopmental disorders, and substance abuse are common. A large proportion of these patients have committed violent crimes. Their care is involuntary, and their caregivers' mission is complex: not only to rehabilitate the patient, but also to consider their risk for reoffending and their risk to society. The objective of this overview of systematic reviews is to identify, appraise, and summarize the existing knowledge in forensic psychiatric care and identify knowledge gaps that require further research.

    Methods: We undertook a systematic literature search for systematic reviews in five defined domains considered important in daily clinical practice within the forensic psychiatric care: (1) diagnostic assessment and risk assessments; (2) pharmacological treatment; (3) psychological interventions; (4) psychosocial interventions, rehabilitation, and habilitation; and (5) restraint interventions. The target population was mentally disordered offenders (forensic psychiatric patients aged >15 years). Each abstract and full text review was assessed by two of the authors. Relevant reviews then were assessed for bias, and those with moderate or low risk of bias were included.

    Results: Of 38 systematic reviews meeting the inclusion criteria, only four had a moderate risk of bias. Two aimed to incorporate as many aspects of forensic psychiatric care as possible, one investigated non-pharmacological interventions to reduce aggression in forensic psychiatric care, and one focused on women with intellectual disabilities in forensic care. However, most of the primary studies included in these reviews had high risks of bias, and therefore, no conclusions could be drawn. All of our identified domains must be considered knowledge gaps.

    Conclusion: We could not answer any of our research questions within the five domains because of the high risk of bias in the primary studies in the included systematic reviews. There is an urgent need for more research on forensic psychiatric care since all of our studied domains were considered knowledge gaps.

  • Williams, Kathryn J.H.
    et al.
    Lee, Kate E.
    Hartig, Terry
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för bostads- och urbanforskning (IBF). Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Sargent, Leisa D.
    Williams, Nicholas S.G.
    Johnson, Katherine A.
    Conceptualising creativity benefits of nature experience: Attention restoration and mind wandering as complementary processes2018Inngår i: Journal of Environmental Psychology, ISSN 0272-4944, E-ISSN 1522-9610, Vol. 59, s. 36-45Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Accumulating evidence indicates that time spent in natural environments promotes creativity, but few researchers have considered how this occurs. We evaluate two candidate mechanisms, attention restoration and mind wandering. We compare the accounts in terms of attentional focus, brain network activation, cognitive effects, and the temporal progression of these processes across the stages of creativity. Based on this analysis, we propose that (1) gentle shifts between externally oriented soft fascination and internally oriented mind wandering can occur during nature experience; (2) this provides the basis for mutually reinforcing pathways that enhance attention control following nature experience; and (3) mind wandering might support additional benefits for creativity, including flexibility and new associations of ideas. We propose research to test the proposed pathways, including the conditions under which environments influence creativity, the ebb and flow of attention orientation during environmental experience, and the links between attentional focus, brain network activation and creativity.

  • Terranova, Nadia
    et al.
    Merck Serono SA, Merck Inst Pharmacometr, Zurich, Switzerland.
    Smith, Mike K.
    Pfizer, Global Clin Pharmacol, Sandwich, Kent, England.
    Nordgren, Rikard
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Comets, Emmanuelle
    INSERM, UMR 1137, IAME, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, IAME, UMR 1137, Paris, France.
    Lavielle, Marc
    Inria Ile De France, Paris, France;Ecole Polytech, Paris, France.
    Harling, Kajsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Hooker, Andrew
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Sarr, Celine
    Pharmetheus, Uppsala, Sweden.
    Mentre, France
    INSERM, UMR 1137, IAME, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, IAME, UMR 1137, Paris, France.
    Yvon, Florent
    EMBL European Bioinformat Inst, Cambridge, England; Barcelona Supercomp Ctr, Barcelona, Spain.
    Swat, Maciej J.
    EMBL European Bioinformat Inst, Cambridge, England; Simcyp, Sheffield, S Yorkshire, England.
    The Standard Output: A Tool-Agnostic Modeling Storage Format2018Inngår i: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, ISSN 2163-8306, Vol. 7, nr 9, s. 543-546Artikkel i tidsskrift (Annet vitenskapelig)
  • Östling, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    High Accuracy Speed and Angular Position Detection by Dual Sensor2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    For many decades there has been a need in many industries to measure speed and position of ferrous gears. This is commonly done by converting passing gear teeth from trigger wheels to electrical impulses to calculate speed and angular position.

    By using Hall effect sensors or Giant Magnetoresistance sensors (GMR), a zero speed detection of gear teeth is possible while at the same time be cheap to produce and durable for harsh environments.

    A specially designed trigger-wheel (cogwheel created for measurements) with gear teeth in a specific pattern, exact position can be detected by using a dual sensor, even when no earlier information is available. The new design of trigger-wheel also makes this new method more accurate and universal compared to previous solutions.

    This thesis demonstrates and argues for the advantages of using a dual sensor for speed and angular position detection on gear wheels. Were one sensor do quantitative measurements for pattern detection in the teeth arrangements and the other sensor do qualitative measurements for position detection.

  • Nilsson, Joacim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper.
    Laddinfrastruktur för elbilar vid stora trafikflöden och event: När uppstår problem och vilka är dess portabla lösningar?2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    The share of cars being powered by electricity is rising in Sweden. So far, this has seldom been causing queues at charging stations but if the rise continues as expected, it might potentially be a problem in the future. This thesis aims to shed light on when this might become a problem in a certain area and give example of a potential solution for that case. Three scenarios with different shares of cars being electric is analyzed with a simple model of a system with fast chargers for an area with a highly variable traffic flow. The arrival times to the system is derived from measured traffic flow and extrapolated up until 2030 and a charging time is set based on assumed travel behavior. A comparison is made between the expected electricity consumption using this approach and actual data from a fast charging station. The comparison indicates that electric cars are not being used for the winter time cross-country trips analyzed here in the same extent as conventional cars. The potential to keep the number of stationary fast chargers down using a portable solution with Li-ion battery storage with and without attached production of electricity for situations with a higher than normal charging demand is then investigated. A containerized Li-ion battery solution of 760 kWh has the potential to replace two 50 kW fast chargers in the studied case.

  • Vilhelmsson, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Elektricitetslära.
    Förebyggande underhåll av elmotorer2018Independent thesis Basic level (university diploma), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Den här rapporten berättar om mitt examensarbete inom förebyggande underhåll på Pappersmaskin 12 hos Holmen Paper i Hallstavik. Förebyggande underhåll är en väldigt viktig del av underhållsarbetet för att öka anläggningens tillgänglighet. Ett stopp kostar upp mot 100tkr per timme så även en liten ökning i tillgänglighet kan spara stora pengar. De frågeställningar som rapporten ämnade att svara var:

    - Hur ser ett optimalt förebyggande underhåll ut? - Varför går motorer sönder, finns det något samband mellan motorhaverier? - Finns det vissa problempositioner i processen, och hur ska FU utformas där? - Hur ser det förebyggande motorunderhållet ut på Hallstaviks pappersbruk idag? - finns det likheter/skillnader mellan det arbetet och leverantörernas rekommendationer?

    För att visa på detta så genomfördes intervjuer med personal, genomgång av data från historiska arbetsordrar samt studiebesök vid ABB service center.  I rapporten beskriver jag olika rekommenderade underhållsåtgärder och jämför dessa med hur man arbetar i Hallstavik. Utöver detta så presenterar jag resultat på vilka positioner det är mest problem med och vilka symptom och orsaker som visats i samband med att en arbetsorder har skrivits. Det framgick att den position som var hårdast drabbad var motorn för formervalsen och att den vanligaste orsaken var vibrationer.

  • Holmberg, Måns
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Dancila, Dragos
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Rydberg, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Hjörvarsson, Björgvin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialfysik.
    Jansson, Ulf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Marattukalam, Jithin J.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialfysik.
    Johansson, Niklas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi.
    Andersson, Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Direct metal laser sintering printed millimeter and submillimeter waveguides2018Konferansepaper (Annet vitenskapelig)
  • Halvarsson, Hampus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper.
    Automated Testing of HVDC Control & Protection Systems: A study on Automated Regression Testing2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    Testing is an important activity when developing a system. Testing requires resources in terms of time, labour and money. By correctly automating the tests, the development time may either be shortened or there will be a possibility to run more tests. ABB in Ludvika has developed MACH, a control & protection system for HVDC (high power electrical transmission over long distances) applications. During development of the control & protection system for each HVDC project, which are all unique, the system is today tested manually, which takes considerable time.This thesis project studies the possibility of automating parts of the MACH system tests, by investigating current testing procedures, the control & protection system itself, and how a test tool may interact with the system. Using this information a test framework, aimed towards test automation, was created, and a simple test execution tool was developed. A new test case, a combination of multiple smaller test cases, ranon the system using the test execution tool.The outcome proves the proof of concept of automating parts of the system tests.The economics and the scope of the automated testing however, is dependent on how automation is implemented.

  • Brykt, Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Signaler och System.
    Development of a Digital Optimal Filter Platform2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    This report is the result of a Master Thesis project which is a part of the Master programme in Electrical Engineering at Uppsala universitet.

    The purpose of this Master Thesis project is to develop an embedded platform for the design and implementation of optimal digital filters, in particular, the Kalman and the Wiener filter. In this project these filters are used for noise reduction on noisy signals. The project is a further development of a previous Master Thesis project where a Universal Filter Bank was developed. The Filter Bankis used for designing and implementing various linear digital filters such as lowpass, highpass, bandpass and bandstop. The Filter Bank is a hand held box with two input and two output connections and a human-device interface (HDI) including a Liquid Crystal Display (LCD) and a keypad. It contains anti-aliasing and reconstruction (analog) filters and an ARM 32-bit Microcontroller Unit (MCU) which is programmed in the C programming language. The HDI lets the user specify a desired digital filter.

    In this project the Kalman and Wiener filtering algorithms were first developed in MATLAB and tested with simulated autoregressive–movingaverage (ARMA) processes (signals) in additive white noise. Aftershown to work, they were implemented on the ARM 32-bit MCU development kit, and finally ported to the Filter Bank. A user interface specially for the specifications of the filters has been created.

    The Kalman and Wiener filtering algorithms have been tested using the same noisy ARMA processes and assessed in terms of the Normalized Mean Square Error (NMSE). The results have shown that both the Wiener and Kalman filters running on the development kit and the Filter Bank are successful in reducing noise. The Kalman filter is shown to perform better than the Wiener filter, which can be due to the extra information about the signal used in the Kalman filter. The performance of both algorithms are heavily dependent on the pre knowledge about the desired signal.

  • Åborg, Annika
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Fakulteten för utbildningsvetenskaper, Institutionen för pedagogik, didaktik och utbildningsstudier.
    Discourse markers and English acquisition.: A corpus-based comparison of essays in year 9 of junior high school and year 3 of senior high school in Sweden2018Independent thesis Advanced level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [en]

    Using a corpus of school essays of Swedish students in year 9 and 12 of junior and senior high school, the present study compares the level of formality and frequency of discourse markers in the respective year groups. Based on previous literature, discourse markers found in the essays are categorized as either formal or informal. Ten randomly selected essays from each year group are analyzed. The results show that there are discrepancies between grade 9 and year 12 in both formality and frequency of discourse markers. The differences can be connected to second language acquisition and contexts in which the Swedish students acquire English. Outer input of English, made possible by new technology and globalization, has a significant impact on language acquisition, a phenomenon which is new and relatively unexplored.  The results of the current study are discussed in the light of the relevance and impacts of the frequent exposure to English through internet activities and media consumption and how it effects language learning. By focusing on discourse markers, which make up an important part of written and spoken language, I attempt to point out patterns that may be relevant and useful for English teachers. Awareness of how combined mechanisms effect and develop students´ acquisition and how to interpret differences in how students use specific grammatical elements such as discourse markers may be useful as a pedagogical analyzing tool. Not least when it comes to the assessment of essays.

  • Gunnarsson, Hampus
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Filosofiska institutionen, Avdelningen för praktisk filosofi.
    The Replaceability Argument: An evaluation of a utilitarian argument for the permissibility of purchasing meat2018Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    The thesis is an evaluation of a utilitarian argument for the permissibility of purchasing meat. The argument, which I call the replaceability argument, rests on four premises:

    1. Meat purchases cause animals to be brought into existence.

    2. The animals brought into existence by meat purchases live lives of positive final value.

    3. If the first two premises are true, then meat purchases cause at least as good consequences as any alternative act.

    4. If meat purchases cause at least as good consequences as any alternative act, then meat purchases are permissible.

    The first three premises are examined while the fourth one, representing consequentialism, is assumed to be true. The evaluation results in the conclusion that the argument is unsound because all of the premises evaluated turn out to be either doubtful or false. 

  • Williams, Kathryn J. H.
    et al.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Lee, Kate E.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Hartig, Terry
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för bostads- och urbanforskning (IBF).
    Sargent, Leisa D.
    UNSW, UNSW Business Sch, Sydney, NSW, Australia.
    Williams, Nicholas S. G.
    Univ Melbourne, Sch Ecosyst & Forest Sci, Baldwin Spencer Bldg, Parkville, Vic 3010, Australia.
    Johnson, Katherine A.
    Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
    Conceptualising creativity benefits of nature experience: Attention restoration and mind wandering as complementary processes2018Inngår i: Journal of Environmental Psychology, ISSN 0272-4944, E-ISSN 1522-9610, Vol. 59, s. 36-45Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Accumulating evidence indicates that time spent in natural environments promotes creativity, but few researchers have considered how this occurs. We evaluate two candidate mechanisms, attention restoration and mind wandering. We compare the accounts in terms of attentional focus, brain network activation, cognitive effects, and the temporal progression of these processes across the stages of creativity. Based on this analysis, we propose that (1) gentle shifts between externally oriented soft fascination and internally oriented mind wandering can occur during nature experience; (2) this provides the basis for mutually reinforcing pathways that enhance attention control following nature experience; and (3) mind wandering might support additional benefits for creativity, including flexibility and new associations of ideas. We propose research to test the proposed pathways, including the conditions under which environments influence creativity, the ebb and flow of attention orientation during environmental experience, and the links between attentional focus, brain network activation and creativity.

  • Ekstrand, Elisabeth
    et al.
    Lund Univ, Dept Hlth Sci, Lund, Sweden;Skane Univ Hosp, Dept Hand Surg, Malmo, Sweden.
    Lexell, Jan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Rehabiliteringsmedicin. Lund Univ, Dept Hlth Sci, Lund, Sweden.
    Brogårdh, Christina
    Lund Univ, Dept Hlth Sci, Lund, Sweden;Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden.
    Test-Retest Reliability of The Participation Domain of the Stroke Impact Scale in Persons with Chronic Stroke2018Inngår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 50, nr 9, s. 843-846Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To evaluate the test-retest reliability and variability of the Participation domain of the Stroke Impact Scale (SIS Participation) in persons with stroke as it is widely used to assess perceived participation in rehabilitation after stroke.

    Design: A test-retest design. Subjects: Forty-five persons (mean age 65 years) with mild to moderate disability at least 6 months post-stroke.

    Methods: The SIS Participation domain was rated on 2 occasions, 1 week apart. The test-retest reliability of the total score was evaluated using Kappa statistics. The 8 item scores were evaluated by the proportion of participants who rated the same score (percentage agreement, PA) or +/- 1 point (PA <= 1 point) at T1 and T2. The Svensson method was used to evaluate systematic and random disagreement.

    Results: The test-retest reliability of the total score showed excellent agreement (Kappa coefficient = 0.79). The items showed high PA <= 1 point (> 82%). No items, except 2, showed a systematic disagreement, and no items showed a random disagreement according to the Svensson method.

    Conclusion: The SIS Participation domain is reliable in persons with chronic stroke and mild to moderate disability and can be used to assess perceived participation in this population.

  • Woube, Annie
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Centrum för genusvetenskap.
    Racing against age?: Gender, age, and body among senior participants in women-only sports races2018Inngår i: Loisir et Société, ISSN 0705-3436, E-ISSN 1705-0154, Vol. 41, nr 2, s. 297-310Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of this study is to investigate experiences and meaning-making of exercise and participation in races for women-only among Swedish senior women. Positioned within the framework of discourse theory, post-structuralism, and feminism, the article contains an analysis of how the intersection of gender, age, and the aging body affects articulations of meaning among senior participants in written accounts, interviews, and ethnographical fieldwork on women-only races in Sweden. The study shows that the senior women participate in women-only races in relation to (1) an aging, deteriorating body, (2) a health and exercise trend in Western society, (3) a desire for a single-gendered social context, (4) their own imagined physical (in)capability, (5) male-connoted capacities of physical strength, speed, and stamina, and (6) other senior female athletes who function as role models.

  • Baunsgaard, Carsten Bach
    et al.
    Univ Copenhagen, Rigshosp, Clin Spinal Cord Injuries, Havnevej 25, DK-3100 Hornbaek, Denmark.
    Nissen, Ulla Vig
    Univ Copenhagen, Rigshosp, Clin Spinal Cord Injuries, Havnevej 25, DK-3100 Hornbaek, Denmark.
    Brust, Anne Katrin
    SPC, Nottwil, Switzerland.
    Frotzler, Angela
    SPC, Nottwil, Switzerland.
    Ribeill, Cornelia
    Ulm Univ, SCI Ctr Orthopaed Dept, Ulm, Germany.
    Kalke, Yorck-Bernhard
    Ulm Univ, SCI Ctr Orthopaed Dept, Ulm, Germany.
    Leon, Natacha
    FLM, Madrid, Spain.
    Gomez, Belen
    FLM, Madrid, Spain.
    Samuelsson, Kersti
    Linkoping Univ, Dept Rehabil Med, Linkoping, Sweden;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
    Antepohl, Wolfram
    Linkoping Univ, Dept Rehabil Med, Linkoping, Sweden;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
    Holmstrom, Ulrika
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi. Uppsala Univ Hosp, Spinal Cord Rehabil Unit, Uppsala, Sweden.
    Marklund, Niklas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi. Uppsala Univ Hosp, Spinal Cord Rehabil Unit, Uppsala, Sweden.
    Glott, Thomas
    Sunnaas Rehabil Hosp, Nesoddtangen, Norway.
    Opheim, Arve
    Sunnaas Rehabil Hosp, Nesoddtangen, Norway;Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Rehabil Med, Gothenburg, Sweden;Reg Vastra Gotaland, Habilitat & Hlth, Gothenburg, Sweden.
    Benito Penalva, Jesus
    Neurorehabil Hosp, Inst Guttmann, Barcelona, Spain.
    Murillo, Narda
    Neurorehabil Hosp, Inst Guttmann, Barcelona, Spain.
    Nachtegaal, Janneke
    Heliomare Rehabil Ctr, Wijk Aan Zee, Netherlands.
    Faber, Willemijn
    Heliomare Rehabil Ctr, Wijk Aan Zee, Netherlands.
    Biering-Sorensen, Fin
    Univ Copenhagen, Rigshosp, Clin Spinal Cord Injuries, Havnevej 25, DK-3100 Hornbaek, Denmark.
    Exoskeleton Gait Training After Spinal Cord Injury: An Exploratory Study on Secondary Health Conditions2018Inngår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 50, nr 9, s. 806-813Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To explore changes in pain, spasticity, range of motion, activities of daily living, bowel and lower urinary tract function and quality of life of individuals with spinal cord injury following robotic exoskeleton gait training.

    Design: Prospective, observational, open-label multicentre study. Methods: Three training sessions per week for 8 weeks using an Ekso GT robotic exoskeleton (Ekso Bionics). Included were individuals with recent (<1 year) or chronic (>1 year) injury, paraplegia and tetraplegia, complete and incomplete injury, men and women.

    Results: Fifty-two participants completed the training protocol. Pain was reported by 52% of participants during the week prior to training and 17% during training, but no change occurred longitudinally. Spasticity decreased after a training session compared with before the training session (p< 0.001), but not longitudinally. Chronically injured participants increased Spinal Cord Independence Measure (SCIM III) from 73 to 74 (p= 0.008) and improved life satisfaction (p= 0.036) over 8 weeks of training. Recently injured participants increased SCIM III from 62 to 70 (p<0.001), but no significant change occurred in life satisfaction. Range of motion, bowel and lower urinary function did not change over time.

    Conclusion: Training seemed not to provoke new pain. Spasticity decreased after a single training session. SCIM III and quality of life increased longitudinally for subsets of participants.

  • Skuladottir, Gudrun Valgerdur
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi. Univ Iceland, Dept Physiol, Fac Med, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland.
    Oskarsdottir, Harpa
    Univ Iceland, Dept Physiol, Fac Med, Vatnsmyrarvegur 16, IS-101 Reykjavik, Iceland.
    Pisanu, Claudia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi. Univ Cagliari, Dept Biomed Sci, Cagliari, Italy.
    Sjodin, Marcus
    Karolinska Inst, Unit Toxicol Sci, Swetox, Sodertalje, Sweden.
    Lindberg, Johan
    Karolinska Inst, Unit Toxicol Sci, Swetox, Sodertalje, Sweden.
    Mwinyi, Jessica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Schiöth, Helgi Birgir
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the FTO gene2018Inngår i: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, ISSN 1178-7007, E-ISSN 1178-7007, Vol. 11, s. 611-618Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. We investigated the association between the polymorphic expression of the fat mass and obesity-associated (FTO) gene and its relationship with SCD activity indices and primary BA concentrations after a low-fat meal. Subjects and methods: Blood plasma samples were collected from 56 young (20-36 years) healthy subjects with different rs9939609 FTO genotypes. Fasting and post-meal (2 hours after a low-fat breakfast) blood samples were collected on the subsequent morning for the analysis of DNA methylation, SCD activity indices (product-to-precursor fatty acid ratios; 16:1n-7/16:0 and 18: 1n-9/18:0), and chenodeoxycholic acid (CDCA) and cholic acid (CA) concentrations. Expression of lipogenic genes was investigated post-meal to assess the relationship between the CDCA and CA concentrations and mRNA levels of lipogenic genes. Results: The FTO AA (obesity risk) genotype group (n = 18) had higher (P<0.05) post-meal SCD-16 activity index than the FTO TT (wild type) genotype group (n=26). In both the FTO TT (n=16) and AA (n=8) genotype groups, the post-meal concentrations of CDCA and CA were lower (P<0.05) compared with the fasted state. No difference in BA concentrations between the FTO TT and AA genotype groups in both meal states was observed. After adjusting for the body mass index, the highest 50% post-meal concentrations of CA were inversely (P=0.010) correlated with the level of mRNA SCD expression. Conclusion: FTO AA carriers may be at a higher risk for obesity through higher SCD activity in a low-fat diet environment. This effect may be partly pronounced by very low CA concentrations.

  • Hanh, Tong Thi Hai
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Naturresurser och hållbar utveckling.
    Boonstra, Wiebren J.
    Stockholm Resilience Centre.
    Can income diversification resolve social-ecological traps in small-scale fisheries and aquaculture in the global south? A case study of response diversity in the Tam Giang lagoon, central Vietnam2018Inngår i: Journal of Ecology and Society, ISSN 1708-3087, Vol. 23, nr 5, artikkel-id 16Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Small-scale fishers and aquaculturists in the global south often face reinforcing feedbacks between resource degradation and livelihood impoverishment, a situation conceptualized as a social-ecological trap. It is argued that these traps can be overcome through income diversification, i.e., livelihoods that are maintained from variable income sources. Our aim was to further scrutinize that claim using the concept of response diversity. To do so, we applied the concept and analyzed income diversification in the Tam Giang lagoon, central Vietnam. Based on our analysis, we argue that high diversity in income activities does not necessarily lead to an escape from social-ecological traps. Although diversity in income activities in the case of the Tam Giang lagoon is relatively high, fisheries- and aquaculture-related income activities continue to dominate livelihood portfolios. The various gear and structures that these activities include all exploit the same ecologies, habitats, and niches of the lagoon. This finding triggers questions concerning the relative contribution of income activities to household income, but also how activities are (differently) connected to natural environments. Income diversification can only sustain natural resources and improve human well-being if it truly transforms livelihoods by connecting local users in new ways to ecologies and societies.

  • Hansen, Julie
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för Rysslands- och Eurasienstudier.
    Introduction: Translingualism and transculturality in Russian contexts of translation2018Inngår i: Translation Studies, ISSN 1478-1700, E-ISSN 1751-2921, Vol. 11, nr 2, s. 113-121Artikkel i tidsskrift (Annet vitenskapelig)
  • Farida, Seyed Hamed Moazzami
    et al.
    Bu Ali Sina Univ, Dept Biol, Fac Sci, Hamadan, Iran.
    Ghorbani, Abdolbaset
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi. Shahid Beheshti Univ Med Sci, Tradit Med & Mat Med Res Ctr, Tehran, Iran.
    Ajani, Yousef
    IBRC, Plant Bank, Karaj, Iran.
    Sadr, Mohammad
    Encyclopedia Islamica Res Ctr, Hist Sci, Tehran, Iran.
    Mozaffarian, Valiollah
    Res Inst Forests & Rangelands, Tehran, Iran.
    Ethnobotanical Applications and Their Correspondence with Phylogeny in Apiaceae-Apioideae2018Inngår i: RESEARCH JOURNAL OF PHARMACOGNOSY, ISSN 2345-5977, Vol. 5, nr 3, s. 79-97Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The Apiaceae family includes some of the most known medicinal, food and spice species in the world some of which have been used by humans since antiquity. Local people in different regions use many species of the family but the information regarding their uses is scattered. Traditionally used species are good candidates for bioprospecting. Combining traditional uses with phylogenetic data helps in selecting species for bioprospecting. In the present study, an ethnobotanical literature review was conducted to outline a comprehensive overview of the ethnobotanical importance of the family in Iran. To highlight the most ethnobotanically used groups in the family, ethnobotanical data were overlapped with generic phylogeny tree of the subfamily Apioideae. In total, 72 species (17.27%) from 42 genera (33.87%) were found to have ethnobotanical uses. Main uses of the family members were medicinal purposes (67.30%) followed by culinary (25%) and ethnoveterinary (11.11%) uses. Two categories of potential species groups for further bioprospecting investigations have been identified based on the phylogenetic analysis. Based on the findings of the present study, phylogenetic analysis can help in identifying potential groups for bioprospecting studies. More rigorous phylogenetic analysis that combines chemotaxonomy data, ethnomedicinal data and phylogenetic data are necessary to pinpoint exact lineages for specific medicinal properties.

  • Leonard, Dag
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Svenungsson, E.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Dahlqvist, Johanna
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Alexsson, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Ärlestig, L.
    Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden.
    Taylor, K. E.
    Univ Calif San Francisco, Rosalind Russell Ephraim P Engleman Rheumatol Res, San Francisco, CA 94143 USA.
    Sandling, Johanna K.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Bengtsson, C.
    Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden.
    Frodlund, M.
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Jönsen, A.
    Skane Univ Hosp, Dept Rheumatol, Lund, Sweden.
    Eketjäll, S.
    Karolinska Inst, Cardiovasc & Metab Dis, Innovat Med & Early Dev Biotech Unit, AstraZeneca,ICMC, Huddinge, Sweden.
    Jensen-Urstad, K.
    Karolinska Inst, Dept Clin Physiol, Stockholm, Sweden.
    Gunnarsson, I.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Sjöwall, C.
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Bengtsson, A. A.
    Skane Univ Hosp, Dept Rheumatol, Lund, Sweden.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Rantapää-Dahlqvist, S.
    Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden.
    Criswell, L. A.
    Univ Calif San Francisco, Rosalind Russell Ephraim P Engleman Rheumatol Res, San Francisco, CA 94143 USA.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis2018Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 77, s. 1063-1069Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have increased risk of cardiovascular disease (CVD). We investigated whether single nucleotide polymorphisms (SNPs) at autoimmunity risk loci were associated with CVD in SLE and RA. Methods Patients with SLE (n=1045) were genotyped using the 200K Immunochip SNP array (Illumina). The allele frequency was compared between patients with and without different manifestations of CVD. Results were replicated in a second SLE cohort (n=1043) and in an RA cohort (n=824). We analysed publicly available genetic data from general population, performed electrophoretic mobility shift assays and measured cytokine levels and occurrence of antiphospholipid antibodies (aPLs). Results We identified two new putative risk loci associated with increased risk for CVD in two SLE populations, which remained after adjustment for traditional CVD risk factors. An IL19 risk allele, rs17581834(T) was associated with stroke/myocardial infarction (MI) in SLE (OR 2.3 (1.5 to 3.4), P=8.5×10−5) and RA (OR 2.8 (1.4 to 5.6), P=3.8×10−3), meta-analysis (OR 2.5 (2.0 to 2.9), P=3.5×10−7), but not in population controls. The IL19 risk allele affected protein binding, and SLE patients with the risk allele had increased levels of plasma-IL10 (P=0.004) and aPL (P=0.01). An SRP54-AS1 risk allele, rs799454(G) was associated with stroke/transient ischaemic attack in SLE (OR 1.7 (1.3 to 2.2), P=2.5×10−5) but not in RA. The SRP54-AS1 risk allele is an expression quantitative trait locus for four genes. Conclusions The IL19 risk allele was associated with stroke/MI in SLE and RA, but not in the general population, indicating that shared immune pathways may be involved in the CVD pathogenesis in inflammatory rheumatic diseases.

  • Boer, Jeltje
    et al.
    Netherlands Pharmacovigilance Ctr Lareb, Shertogenbosch, Netherlands.
    Ederveen, Ellen
    Netherlands Pharmacovigilance Ctr Lareb, Shertogenbosch, Netherlands.
    Grundmark, Birgitta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi. Uppsala Monitoring Ctr, Uppsala, Sweden.
    Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 174-178Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Desloratadine, a third-generation antihistamine, is claimed to cause fewer central nervous system (CNS) adverse drug reactions (ADRs) than antihistamines of the first- and second-generation. While literature is inconclusive regarding the possible CNS effects, symptoms like somnolence and hallucinations are acknowledged ADRs of desloratadine, indeed suggesting some passage of this drug across the blood-brain barrier. Depression is currently not described as an ADR in the approved desloratadine product labelling.

    Materials and methods: In a joint signal detection workshop with the Uppsala Monitoring Centre and the Netherlands Pharmacovigilance Centre Lareb, case reports of suspected drug-ADR associations were analysed.

    Results: Forty-nine unique case reports of desloratadine associated with depression or depressed mood were detected in the WHO global ADR database. In these reports, the median time to onset of depression was three days. Most patients recovered after withdrawal of desloratadine, and in five patients the symptoms of depression recurred after re-administration of desloratadine.

    Conclusion: We hypothesize that desloratadine may enter the CNS and that it hence in rare cases may cause a clinically relevant state of depression, a relation that patients and their treating physicians should be made aware of.

  • Jansson, Emil
    et al.
    Avesta Hosp, Dept Internal Med, Avesta, Sweden.
    Nevéus, Tryggve
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Rectal diameter assessment in enuretic children-exploring the association between constipation and bladder function2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 179-182Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: Detrusor overactivity and constipation often co-exist in children with enuresis. Constipation is known to be linked to detrusor overactivity. The voiding chart is the best non-invasive way to investigate bladder function, whereas the ultrasonographical detection of rectal dilatation is the best way to objectify constipation. We wanted to investigate a possible relationship between the rectal diameter and voiding chart data in enuretic children.

    Methods: Children with therapy-resistant enuresis were retrospectively evaluated. All had completed a voiding chart for at least 48 h. The rectal diameter was assessed ultrasonographically. The cutoff for rectal dilatation was set at 30 mm.

    Results: We evaluated 74 patients (12 girls) aged 10.2 +/- 2.8years, 35 of whom had rectal dilatation. No significant differences in voiding chart parameters were found between children with normal versus dilated rectum. Neither did urgency or a history of daytime incontinence differ between the groups. Boys were more likely to have rectal dilatation than girls (p = 0.02).

    Conclusions: The absence of differences regarding voiding chart data may be explained as two mechanisms neutralizing each other: behavioral factors may make the constipated children void seldom and with large volumes, whereas detrusor overactivity caused by rectal compression of the bladder may have the opposite effect. Another option may be that the voiding chart is too blunt an instrument to detect detrusor overactivity. Constipation, and thus presumably bladder dysfunction, seems to be more important in enuretic boys than girls.

  • Karlsson, Torbjörn
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi. Uppsala Univ Hosp, Ctr Oslers Dis, Uppsala, Sweden;Vastmanlands Hosp, Dept Med, Vasteras, Sweden.
    Cherif, Honar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi. Uppsala Univ Hosp, Ctr Oslers Dis, Uppsala, Sweden.
    Mutations in the ENG, ACVRL1, and SMAD4 genes and clinical manifestations of hereditary haemorrhagic telangiectasia: experience from the Center for Osler's Disease, Uppsala University Hospital2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 153-157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim: The aim of this retrospective single-centre study was to evaluate whether mutations in the ENG, ACVRL1, and SMAD4 genes were associated with different phenotypes in hereditary haemorrhagic telangiectasia (HHT).

    Methods: The case records of 21 HHT patients with verified mutations in ENG, ACVRL1, or SMAD4 genes were reviewed. The numbers of HHT diagnostic criteria fulfilled for the three genotypes were compared, as was the prevalence of complications such as iron deficiency anaemia, gastrointestinal haemorrhage, stroke, and cerebral abscess.

    Results: Our results indicate that mutations in the ENG (HHT1), ACVRL1 (HHT2), and SMAD4 genes result in different HHT phenotypes. Epistaxis debuts earlier and may be more severe in HHT1 than in HHT2. The prevalence of pulmonary arteriovenous malformations (AVM) is higher in HHT type 1, whereas hepatic AVMs are more common in HHT2. One patient with mutations in both ENG and ACVRL1 genes was identified, as were two SMAD4-mutated patients suffering from the overlapping juvenile polyposis-HHT syndrome. Nearly one in five patients in our HHT population has been diagnosed with stroke or cerebral abscess, indicating a high prevalence of cerebral complications.

    Conclusion: Our results showing that ENG and ACVRL1 gene mutations result in different HHT phenotypes confirm the results from other HHT centres worldwide. Cerebral complications of HHT are common, underscoring the importance of regular screening for pulmonary AVMs and early intervention against such AVMs. We have identified an HHT patient with simultaneous mutations in the ENG and ACVRL1 genes. Surprisingly, this patient has had a mild course of the disease.

  • Barkelind, Malin
    Bobcatsss 2018 i Riga2018Inngår i: Tidskrift för ABM, ISSN 2002-4614, Vol. 3, nr 1, s. 40-48Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Bobcatsss är en biblioteks- och informationsvetenskapskonferens som anordnas årligen av studenter. Årets tema var läsning och författaren berättar här om några intressanta föredrag och infallsvinklar som inspirerade denne. Konferensen hölls i Riga och författaren besökte bland annat Lettlands nya nationalbibliotek och världsarvet Vecrīga, Rigas historiska centrum

  • Hayashi, Masaki
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Neurodrug: Slapstick Effects by Destroying Neurons in a Neural Network2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    We propose a method to possibly generate slapstick effects by deliberately cutting out, tampering and re-connecting neurons in the neural network which has been trained in a proper way. We have developed two applications of a drumbeat generator and a CG character animation as the experiments to try out the idea. The results look interesting and show a certain potential for entertainment and also a viable way of interactive art.

  • Hayashi, Masaki
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Bachelder, Steven
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Tsuruta, Naoya
    Tokyo University of Technology, Tokyo, Japan.
    Sasaki, Kazuo
    Tokyo University of Technology, Tokyo, Japan.
    Kondo, Kunio
    Tokyo University of Technology, Tokyo, Japan.
    Wordpress-based Blog System with a Capability of Showing Entries by TV-program-like CG Animations2018Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    We have developed a blog system with Wordpress which has a capability of automatically converting its blog entries into CG animations. By embedding necessary functions in Wordpress' s theme, a user can select this theme and construct a blog where readers can watch CG animation instead of reading the blog entry. The CG animation is created by TVML (TV program Making Language) technology which enables to make a TV-program-like animation with CG characters with synthesized voices, image data display, sound data playback, superimposing and so on. Not only to contribute to the Wordpress community, in particular, expected as an auxiliary function of the blog service, but also this could work as a production tool for creating various types of CG animations rather than blogging assistance.

  • Apruzzi, Fabio
    et al.
    Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA;Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA.
    Heckman, Jonathan J.
    Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA.
    Morrison, David R.
    Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA;Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA.
    Tizzano, Luigi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    4D gauge theories with conformal matter2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 9, artikkel-id 088Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One of the hallmarks of 6D superconformal field theories (SCFTs) is that on a partial tensor branch, all known theories resemble quiver gauge theories with links comprised of 6D conformal matter, a generalization of weakly coupled hypermultiplets. In this paper we construct 4D quiverlike gauge theories in which the links are obtained from compactifications of 6D conformal matter on Riemann surfaces with flavor symmetry fluxes. This includes generalizations of super QCD with exceptional gauge groups and quarks replaced by 4D conformal matter. Just as in super QCD, we find evidence for a conformal window as well as confining gauge group factors depending on the total amount of matter. We also present F-theory realizations of these field theories via elliptically fibered Calabi-Yau fourfolds. Gauge groups (and flavor symmetries) come from 7-branes wrapped on surfaces, conformal matter localizes at the intersection of pairs of 7-branes, and Yukawas between 4D conformal matter localize at points coming from triple intersections of 7-branes. Quantum corrections can also modify the classical moduli space of the F-theory model, matching expectations from effective field theory.

  • Hagberg, Niklas
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Joelsson, M.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Leonard, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Reid, Sarah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mo, J.
    AstraZeneca, Resp Inflammat & Autoimmun, IMED Biotech Unit, Gothenburg, Sweden.
    Nilsson, M.
    AstraZeneca, Resp Inflammat & Autoimmun, IMED Biotech Unit, Gothenburg, Sweden.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Bryceson, Y. T.
    Karolinska Inst, Dept Med, Ctr Hematol & Regenerat Med, Karolinska Univ Hosp Huddinge, Stockholm, Sweden;Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE2018Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 77, s. 668-668Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. This study aimed to clarify how the SLE-associated intronic STAT4 risk allele rs7574865[T] affects the function of immune cells in SLE. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from 52 genotyped patients with SLE. Phosphorylation of STAT4 (pSTAT4) and STAT1 (pSTAT1) in response to interferon (IFN)-α, IFN-γ or interleukin (IL)-12, total levels of STAT4, STAT1 and T-bet, and frequency of IFN-γ+ cells on IL-12 stimulation were determined by flow cytometry in subsets of immune cells before and after preactivation of cells with phytohaemagglutinin (PHA) and IL-2. Cellular responses and phenotypes were correlated to STAT4 risk allele carriership. Janus kinase inhibitors (JAKi) selective for TYK2 (TYK2i) or JAK2 (JAK2i) were evaluated for inhibition of IL-12 or IFN-γ-induced activation of SLE PBMCs. Results In resting PBMCs, the STAT4 risk allele was neither associated with total levels of STAT4 or STAT1, nor cytokine-induced pSTAT4 or pSTAT1. Following PHA/IL-2 activation, CD8+ T cells from STAT4 risk allele carriers displayed increased levels of STAT4 resulting in increased pSTAT4 in response to IL-12 and IFN-α, and an augmented IL-12-induced IFN-γ production in CD8+ and CD4+ T cells. The TYK2i and the JAK2i efficiently blocked IL-12 and IFN-γ-induced activation of PBMCs from STAT4 risk patients, respectively. Conclusions T cells from patients with SLE carrying the STAT4 risk allele rs7574865[T] display an augmented response to IL-12 and IFN-α. This subset of patients may benefit from JAKi treatment.

  • Ye, Zou
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Challenges and Status of the ESSnuSB Accumulator Design2018Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    The 2.0 GeV, 5 MW proton linac for the European Spallation Source, ESS, will have the capacity to accelerate additional pulses, interleaved with the proton pulses for neutron production, and send them to a neutrino target, providing an excellent opportunity to produce an unprecedented high- performance neutrino beam, the ESS neutrino Super Beam (ESSnuSB), to measure, with precision, the CP violating phase at the 2nd oscillation maximum. In order to comply with the acceptance of the target and horn systems that will form the neutrino super beam, the long pulses from the linac must be compressed by about three orders of magnitude with minimal particle loss, something that will be achieved in an accumulator ring. This ring will accommodate about 1015 protons, which means that several design challenges are encountered. Strong space charge forces, low-loss injection, efficient collimation, and e-p instabilities are some of the aspects central to the design work. Different pulse structures and injection painting schemes have been studied, with the goal of mitigating space charge effects and of minimizing the heating of the stripping foil despite the very high beam intensity. This paper presents the status of the accumulator ring design, with multi- particle simulations of the injection procedure.

  • Hayashi, Masaki
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Bachelder, Steven
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Nakajima, Masayuki
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Automatic Generation of CG Animation from the Internet Forum "2 Channeru"2018Inngår i: Journal of the Institute of Image Information and Television Engineers, ISSN 1342-6907, Vol. 72, nr 10, s. 189-196Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [ja]

    Web サイトをはじめとする様々な情報をテレビ番組的なCG アニメーションに自動変換する研究開発を進めている.今回,その試みの一つとして,「2ちゃんねる掲示板」からコンピュータ・グラフィックス(CG) アニメーションを自動生成するアプリケーションを開発した.基本的な方法は,実際のテレビ番組映像を分析し,そこで使われている制作ノウハウを抽出して,これをルール化および数値化し,ソフトウェアに実装することで,テレビ番組を真似たCG アニメーションを得るというものである.今回,実際に放送された1 時間分の討論番組映像のカメラスイッチングを解析しアルゴリズム化した.本論文では,このプロセスの詳細を説明し,この方法により作成した実際のアプリケーションについて述べる.また,得られたCG アニメーションについて評価実験を行い,本手法の有効性と今後の課題を明らかにしたので,これについて述べる.