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  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis de ambarvalibus sacris, quam ... sub praesidio ... dn. Johannis Hermansson ... publico candidorum examini modeste sistit Petrus G. Kexerus .... In audit. Gust. maj. die 3. Febr. anni MDCCXXVII. horis ante meridiem solitis.1727Dissertation (older thesis) (Other academic)
  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de obedientia civili, quam, suffragante ampliss. senat. Philos. in Reg. Academ. Upsal. sub præsidio ... Dn. Johannis Hermansson ... publico examini modeste submittit S:æ R:æ M:tis alumnus Nicolaus Lindman Arosia-Westmannus, In Audit. Gust. Maj. d. 22. Decemb. Anni MDCCXXVI. Horis post merid. solitis.1726Dissertation (older thesis) (Other academic)
  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertationis politicæ partem priorem, de usu pactorum et foederum, ex consensu ampliss. facult. phil. in reg. Upsalensi lyceo, præside ... mag. Johanne Hermansson ... publicæ bonorum censuræ modeste submittit alumnus regius Olaus Norberg, Westmannus. In audit. Carol. maj. die 22 decembris anni MDCCXXVI. horis ante meridiem solitis.1726Dissertation (older thesis) (Other academic)
  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historico-politica, de bello Mithridatico, cujus partem priorem, consensu ampliss. Senatus Philos. in regio Upsalensium Lycæo, præside ... Dn. Johanne Hermansson ... publice ventilandam sistit S:æ R:æ M:tis Alumnus, Laurentius Portuan, Gestricius. In Audit. Gust. Maj. horis ante merid. consvetis, d. XII. Decemb. A. O. R. MDCCXXVI.1726Dissertation (older thesis) (Other academic)
  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio politica de frugalitate civili, quam ... sub præsidio celeberrimi viri, dn. Johannis Hermansson ... publico bonorum examini modeste submittit Jonas J. Wahlborg, V. Gothus. In audit. Gustav. maj. ad diem IV. Junii M DCC XXVI. Horis ante meridiem solitis.1726Dissertation (older thesis) (Other academic)
  • Hermansson, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Specimen academicum de effectibus avaritiæ, quod, cum consensu ampliss. fac. Philos. in Regia Academ. Upsaliensi, præside ... Dn. Johanne Hermansson ... publicæ ventilationi modeste subjicit Nicolaus Spak Wermelandus. Ad diem 18 Maji A. MDCCXXVI, In Audit. Gustav. Maj. Horis ante meridiem solitis.1726Dissertation (older thesis) (Other academic)
  • Public defence: 2017-12-05 09:00 Rosénsalen, Uppsala
    Emami Khoonsari, Payam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Proteomics Studies of Subjects with Alzheimer’s Disease and Chronic Pain2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Alzheimer’s disease (AD) is a neurodegenerative disease and the major cause of dementia, affecting more than 50 million people worldwide. Chronic pain is long-lasting, persistent pain that affects more than 1.5 billion of the world population. Overlapping and heterogenous symptoms of AD and chronic pain conditions complicate their diagnosis, emphasizing the need for more specific biomarkers to improve the diagnosis and understand the disease mechanisms.

    To characterize disease pathology of AD, we measured the protein changes in the temporal neocortex region of the brain of AD subjects using mass spectrometry (MS). We found proteins involved in exo-endocytic and extracellular vesicle functions displaying altered levels in the AD brain, potentially resulting in neuronal dysfunction and cell death in AD.

    To detect novel biomarkers for AD, we used MS to analyze cerebrospinal fluid (CSF) of AD patients and found decreased levels of eight proteins compared to controls, potentially indicating abnormal activity of complement system in AD.

    By integrating new proteomics markers with absolute levels of Aβ42, total tau (t-tau) and p-tau in CSF, we improved the prediction accuracy from 83% to 92% of early diagnosis of AD. We found increased levels of chitinase-3-like protein 1 (CH3L1) and decreased levels of neurosecretory protein VGF (VGF) in AD compared to controls.

    By exploring the CSF proteome of neuropathic pain patients before and after successful spinal cord stimulation (SCS) treatment, we found altered levels of twelve proteins, involved in neuroprotection, synaptic plasticity, nociceptive signaling and immune regulation.

    To detect biomarkers for diagnosing a chronic pain state known as fibromyalgia (FM), we analyzed the CSF of FM patients using MS. We found altered levels of four proteins, representing novel biomarkers for diagnosing FM. These proteins are involved in inflammatory mechanisms, energy metabolism and neuropeptide signaling.

    Finally, to facilitate fast and robust large-scale omics data handling, we developed an e-infrastructure. We demonstrated that the e-infrastructure provides high scalability, flexibility and it can be applied in virtually any fields including proteomics. This thesis demonstrates that proteomics is a promising approach for gaining deeper insight into mechanisms of nervous system disorders and find biomarkers for diagnosis of such diseases.

    List of papers
    1. Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain
    Open this publication in new window or tab >>Increased levels of extracellular microvesicle markers and decreased levels of endocytic/exocytic proteins in the Alzheimer’s disease brain
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    2016 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 54, no 4, 71 p.1671-1686 p.Article in journal (Refereed) Published
    Abstract [en]

    Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder accounting for more than 50% of all dementia cases. AD neuropathology is characterized by the formation of extracellular plaques and intracellular neurofibrillary tangles consisting of aggregated amyloid-beta and tau, respectively. The disease mechanism has only been partially elucidated and is believed to also involve many other proteins.

    Objective: This study intended to perform a proteomic profiling of post mortem AD brains and compare it with control brains as well as brains from other neurological diseases to gain insight into the disease pathology.

    Methods: Here we used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD, other neurological disorders, and non-demented controls, in order to identify additional proteins that are altered in AD. The mass spectrometry results were verified by antibody suspension bead arrays.

    Results: We found 50 proteins with altered levels between AD and control brains. The majority of these proteins were found at lower levels in AD. Pathway analyses revealed that several of the decreased proteins play a role in exocytic and endocytic pathways, whereas several of the increased proteins are related to extracellular vesicles. Using antibody-based analysis, we verified the mass spectrometry results for five representative proteins from this group of proteins (CD9, HSP72, PI42A, TALDO, and VAMP2) and GFAP, a marker for neuroinflammation.

    Conclusions: Several proteins involved in exo-endocytic pathways and extracellular vesicle functions display altered levels in the AD brain. We hypothesize that such changes may result in disturbed cellular clearance and a perturbed cell-to-cell communication that may contribute to neuronal dysfunction and cell death in AD.

    Publisher
    71 p.
    Keyword
    Brain, Proteomics, Mass spectrometry, Alzheimer's disease
    National Category
    Analytical Chemistry Geriatrics Neurosciences
    Research subject
    Chemistry with specialization in Analytical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-277617 (URN)10.3233/JAD-160271 (DOI)000386749900034 ()27636840 (PubMedID)
    Funder
    VINNOVALars Hierta Memorial FoundationSwedish Research Council, P29797-1; 621-2011-4423Knut and Alice Wallenberg FoundationStiftelsen Gamla Tjänarinnor
    Available from: 2016-02-22 Created: 2016-02-22 Last updated: 2017-10-17Bibliographically approved
    2. Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
    Open this publication in new window or tab >>Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
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    2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 3, e0150672Article in journal (Refereed) Published
    Abstract [en]

    Alzheimer's disease is a neurodegenerative disorder accounting for more than 50% of cases of dementia. Diagnosis of Alzheimer's disease relies on cognitive tests and analysis of amyloid beta, protein tau, and hyperphosphorylated tau in cerebrospinal fluid. Although these markers provide relatively high sensitivity and specificity for early disease detection, they are not suitable for monitor of disease progression. In the present study, we used label-free shotgun mass spectrometry to analyse the cerebrospinal fluid proteome of Alzheimer's disease patients and non-demented controls to identify potential biomarkers for Alzheimer's disease. We processed the data using five programs (DecyderMS, Maxquant, OpenMS, PEAKS, and Sieve) and compared their results by means of reproducibility and peptide identification, including three different normalization methods. After depletion of high abundant proteins we found that Alzheimer's disease patients had lower fraction of low-abundance proteins in cerebrospinal fluid compared to healthy controls (p<0.05). Consequently, global normalization was found to be less accurate compared to using spiked-in chicken ovalbumin for normalization. In addition, we determined that Sieve and OpenMS resulted in the highest reproducibility and PEAKS was the programs with the highest identification performance. Finally, we successfully verified significantly lower levels (p<0.05) of eight proteins (A2GL, APOM, C1QB, C1QC, C1S, FBLN3, PTPRZ, and SEZ6) in Alzheimer's disease compared to controls using an antibody-based detection method. These proteins are involved in different biological roles spanning from cell adhesion and migration, to regulation of the synapse and the immune system.

    National Category
    Neurology Geriatrics
    Identifiers
    urn:nbn:se:uu:diva-283774 (URN)10.1371/journal.pone.0150672 (DOI)000371990100049 ()26950848 (PubMedID)
    Funder
    Knut and Alice Wallenberg FoundationMarianne and Marcus Wallenberg FoundationThe Swedish Brain FoundationSwedish Research Council FormasSwedish Research Council, P29797-1Swedish Research Council, 621-2011-4423
    Available from: 2016-04-14 Created: 2016-04-14 Last updated: 2017-10-17Bibliographically approved
    3. Chitinase-3-like protein 1 (CH3L1) and Neurosecretory protein VGF (VGF) as two novel CSF biomarker candidates for improved diagnostics in Alzheimer’s disease
    Open this publication in new window or tab >>Chitinase-3-like protein 1 (CH3L1) and Neurosecretory protein VGF (VGF) as two novel CSF biomarker candidates for improved diagnostics in Alzheimer’s disease
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by amyloid-β (Aβ) plaque deposition and accumulation of intracellular neurofibrillary tangles. This pathology is mirrored in the cerebrospinal fluid (CSF), where decreased Aβ42 together with increased total (t-tau) and phospho-tau (p-tau) today is used as a diagnostic marker. Although these biomarkers have a fairly good sensitivity and specificity, additional biomarkers are needed to further improve the accuracy for early disease detection and to monitor disease development. In this study, we used mass spectrometry-based shotgun proteomics to investigate the CSF proteome of patients with AD and mild cognitive impairment (MCI) as well as of non-demented controls. By combining the diagnostic markers (Aβ42, total t-tau, and p-tau) with a selection of proteomics biomarkers, the accuracy of predicting MCI to AD conversion increased from 83% to 92% with a specificity of 1.0 and sensitivity of 0.86. Among these markers, the levels of protein chitinase-3-like protein 1 (CH3L1) were significantly higher in AD and MCI converters compared to controls. In addition to Aβ42, t-tau, and p-tau the protein CH3L1 contributed mostly to the prediction accuracy. We also found statistically significant lower CSF levels of the neurosecretory protein VGF (VGF) in AD compared to controls. Taken together, our findings suggest that incorporating new CSF biomarkers can further enhance early diagnosis of AD.

    Keyword
    Alzheimer's disease, cerebrospinal fluid, biomarker, diagnostics, neurodegenerative disorder, dementia
    National Category
    Geriatrics Neurosciences
    Research subject
    Geriatrics; Medical Science; Neurology
    Identifiers
    urn:nbn:se:uu:diva-331711 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-25
    4. Spinal Cord Stimulation Alters Protein Levels in the Cerebrospinal Fluid of Neuropathic Pain Patients: A Proteomic Mass Spectrometric Analysis
    Open this publication in new window or tab >>Spinal Cord Stimulation Alters Protein Levels in the Cerebrospinal Fluid of Neuropathic Pain Patients: A Proteomic Mass Spectrometric Analysis
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    2016 (English)In: Neuromodulation (Malden, Mass.), ISSN 1094-7159, E-ISSN 1525-1403, Vol. 19, no 6, 549-562 p.Article in journal (Refereed) Published
    Abstract [en]

    ObjectivesElectrical neuromodulation by spinal cord stimulation (SCS) is a well-established method for treatment of neuropathic pain. However, the mechanism behind the pain relieving effect in patients remains largely unknown. In this study, we target the human cerebrospinal fluid (CSF) proteome, a little investigated aspect of SCS mechanism of action. MethodsTwo different proteomic mass spectrometry protocols were used to analyze the CSF of 14 SCS responsive neuropathic pain patients. Each patient acted as his or her own control and protein content was compared when the stimulator was turned off for 48 hours, and after the stimulator had been used as normal for three weeks. ResultsEighty-six proteins were statistically significantly altered in the CSF of neuropathic pain patients using SCS, when comparing the stimulator off condition to the stimulator on condition. The top 12 of the altered proteins are involved in neuroprotection (clusterin, gelsolin, mimecan, angiotensinogen, secretogranin-1, amyloid beta A4 protein), synaptic plasticity/learning/memory (gelsolin, apolipoprotein C1, apolipoprotein E, contactin-1, neural cell adhesion molecule L1-like protein), nociceptive signaling (neurosecretory protein VGF), and immune regulation (dickkopf-related protein 3). ConclusionPreviously unknown effects of SCS on levels of proteins involved in neuroprotection, nociceptive signaling, immune regulation, and synaptic plasticity are demonstrated. These findings, in the CSF of neuropathic pain patients, expand the picture of SCS effects on the neurochemical environment of the human spinal cord. An improved understanding of SCS mechanism may lead to new tracks of investigation and improved treatment strategies for neuropathic pain.

    Keyword
    Cerebrospinal fluid, mechanism of action, neuropathic pain, spinal cord stimulation
    National Category
    Neurology Radiology, Nuclear Medicine and Medical Imaging
    Identifiers
    urn:nbn:se:uu:diva-304434 (URN)10.1111/ner.12473 (DOI)000382755300001 ()27513633 (PubMedID)
    Funder
    VINNOVASwedish Research Council
    Available from: 2016-10-05 Created: 2016-10-05 Last updated: 2017-10-17Bibliographically approved
    5. Systematic Analysis of the Cerebrospinal Fluid Proteome of Fibromyalgia patients
    Open this publication in new window or tab >>Systematic Analysis of the Cerebrospinal Fluid Proteome of Fibromyalgia patients
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the clinicians. We have performed shotgun proteomics on cerebrospinal fluid (CSF) from FM patients and non-pain controls to find potential biomarker candidates for this syndrome. Based on our multivariate and univariate analyses, we found that the relative differences in the CSF proteome between FM patients and controls were moderate. Four proteins, important to discriminate FM patients from non-pain controls, were found: Apolipoprotein C-III, Galectin-3-binding protein, Malate dehydrogenase cytoplasmic and the neuropeptide precursor protein ProSAAS. These proteins are involved in lipoprotein lipase (LPL) activity, inflammatory signaling, energy metabolism and neuropeptide signaling.

    Keyword
    cerebrospinal fluid, biomarker, chronic pain, fibromyalgia, inflammation, neuroinflammation, mass spectrometry
    National Category
    Health Sciences Neurosciences Clinical Laboratory Medicine Biomedical Laboratory Science/Technology
    Research subject
    Bioinformatics; Biology with specialization in Molecular Biology; Chemistry with specialization in Analytical Chemistry; Medical Science; Clinical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-331615 (URN)
    Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-10-17
    6. Interoperable and scalable metabolomics data analysis with microservices
    Open this publication in new window or tab >>Interoperable and scalable metabolomics data analysis with microservices
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Developing a robust and performant data analysis workflow that integrates all necessary components whilst still being able to scale over multiple compute nodes is a challenging task. We here present a generic method based on microservice architecture, where software tools are encapsulated as Docker containers that can be connected into scientific workflows and executed in parallel using the Kubernetes container orchestrator. The method was developed within the PhenoMeNal consortium to support flexible metabolomics data analysis and was designed as a virtual research environment which can be launched on-demand on cloud resources and desktop computers. IT-expertise requirements on the user side are kept to a minimum, and established workflows can be re-used effortlessly by any novice user. We validate our method on two mass spectrometry studies, one nuclear magnetic resonance spectroscopy study and one fluxomics study, showing that the method scales dynamically with increasing availability of computational resources. We achieved a complete integration of the major software suites resulting in the first turn-key workflow encompassing all steps for mass-spectrometry-based metabolomics including preprocessing, multivariate statistics, and metabolite identification. Microservices is a generic methodology that can serve any scientific discipline and opens up for new types of large-scale integrative data analysis.

    Keyword
    Bioinformatics, e-infrastructure, microservices, metabolomics, kubernetes, Docker, container
    National Category
    Bioinformatics (Computational Biology)
    Research subject
    Bioinformatics
    Identifiers
    urn:nbn:se:uu:diva-331658 (URN)
    Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-10-17
  • Schlegel, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Informationsbeteende i spelskapande: En fallstudie av Paradox Interactive2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis focuses on Paradox Interactive's information seeking as a process in the construction of historical computer games. The study is collecting data through a series of interviews with two professional groups: Content designers and 3D graphics. The study focuses on the role of information gathering as a internal process in the creation of the game but also on how the two professions, which have been involved in the study's interviews, gather information relevant to their specific tasks. The study also touches on whether it exists a connection between how Content designers and 3D graphics conduct their searches for information and the ABM sector (that is archives, libraries and museums) as sources/distributors of information.

    The study has resulted in knowledge regarding the professional groups' information behaviour, what factors that affect the process of gathering information. The study has also resulted in an awareness regarding what kind of information sources that are attractive. Furthermore, the interviews conducted have produced information on how archives, libraries and museums function as information sources for the selected professional groups. The information gathered through the interviews shows that archives, libraries and museums are not used as information sources by the professional groups. Reasons as to why this is the case are a lack of awareness as well as the professional groups' various needs, such as right content and easy accessibility.

    Games which are utilising or relate to popular history are a clear aspect of modern days popular culture. There exists an abundance of games which relate to history whether they are historical strategy-focused computer games or more action-packed videogames constructed around historical events and contexts. There exists an equally abundance of studies which focuses on games in certain aspects; one such area of research is how history is utilised in games. This study, as noted above, doesn't focus on the games themselves or how they utilise history but rather on the specific question of how the developers gather the information about the past, what sources that exists, and how archives, libraries and museums can better accommodate game creators as a specific group of information gatherers and users.

  • Risheim, Lina
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Smedsaas, Klara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Exit game? Any unsaved progress will be lost: En praktikteoretisk analys av relationen mellan svenska spelföretag och ABM-institutioner2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis analyzes the relationship between Swedish video game companies and the institutions for Archive, Libraries and Museums (ALM). The aim is to further the discussion regarding preservation of digital games. The thesis is based on semi-structured interviews with four video game companies and three institutions; an archive, a library and a museum. The theoretical foundation resides within practice theory, with the assumption that a practice is a combination of what people do and what they say. By analyzing what video game companies say they do the authors ascertain which methods of preservation is currently. The analysis is a cross-examination of the seven interviews with the result indicating that while video game companies are interested in the preservation of digital games they do not participate actively in the discussion on the best method of doing so. Communica- tion between video game companies and ALM institutions has room for improvement, as it is virtually non- existent. Furthermore, the findings indicate different motivations for preserving games and it is unclear which perspective the preservation should have; a technical perspective, cultural perspective or for the company’s bene- fit. In conclusion the current situation is that ALM institutions preserve games with a cultural and/or a technical perspective while game companies preserve their games for the company’s benefit. 

  • Legnér, Mattias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History, Conservation.
    1700-talets ortsbeskrivningar2017In: Läroverkssamlingen i ljuset: Almedalsbibliotekets äldre samling / [ed] Maja Markhouss, Uppsala: Uppsala universitetsbibliotek , 2017, 1, 15-21 p.Chapter in book (Other academic)
    Abstract [en]

    Eighteenth century topographical descriptions

     

    The gymnasium library in Visby contains a number of volumes from the time before 1800 describing places (parishes, towns, counties) in Sweden. These topographical descriptions cover topics such as the landscape, customs, history and economic development. In the eighteenth century writing such descriptions became a popular pastime among priests and burghers, and it was seen as an appropriate topic for university students writing their thesis. In the course of the century more than 300 such descriptions were printed in Sweden (including Finland). Some of these descriptions are found in this collection, and three of them are dealt with in the article. The first one was a description of Uppsala and its environs authored by the royal antiquarian Johan Peringskiöld in the early eighteenth century, focusing entirely on the antiquities of the place. The second description was one of the antiquities of Gotland, written in 1730s and 1740s by the superintendent Jöran Wallin. The third one is an account of the county Stora Kopparberg from 1757, written by the merchant Abraham Abrahamsson Hülphers who also published an extensive description of northern Sweden.  

  • Public defence: 2017-12-08 09:15 Å2005, Uppsala
    Rossander, Morgan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Electromechanics of Vertical Axis Wind Turbines2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Wind power is an established mean of clean energy production and the modern horizontal axis wind turbine has become a common sight. The need for maintenance is high and future wind turbines may need to be improved to enable more remote and offshore locations. Vertical axis wind turbines have possible benefits, such as higher reliability, less noise and lower centre of gravity. This thesis focuses on electromechanical interaction in the straight bladed Darrieus rotor (H-rotor) concept studied at Uppsala University.

    One of the challenges with vertical axis technology is the oscillating aerodynamic forces. A force measurement setup has been implemented to capture the forces on a three-bladed 12 kW open site prototype. The normal force showed good agreement with simulations. An aerodynamic torque could be estimated from the system. The total electrical torque in the generator was determined from electrical measurements. Both torque estimations lacked the expected aerodynamic ripple at three times per revolution. The even torque detected is an important result and more studies are required to confirm and understand it.

    The force measurement was also used to study the loads on the turbine in parked conditions. It was discovered that there is a strong dependence on wind direction and that there is a positive torque on the turbine at stand still. The results can assist to determine the best parking strategies for an H-rotor turbine.

    The studied concept also features diode rectification of the voltage from the permanent magnet synchronous generator. Diodes are considered a cheap and robust solution for rectification at the drawback of inducing ripple in the torque and output voltage. The propagation of the torque ripple was measured on the prototype and studied with simulations and analytical expressions. One key conclusion was that the mechanical driveline of the turbine is an effective filter of the diode induced torque ripple.

    A critical speed controller was implemented on the prototype. The controller was based on optimal torque control and according to the experiments and the simulations it was able to avoid a rotational speed span. Finally, the optimal torque control was evaluated for multiple turbines with diode rectification to a common DC-link. The setup can potentially reduce the overall complexity of wind farms. The simulations suggest that stability of the system can be obtained by controlling the DC-link load as a semi constant voltage.

    The thesis is based on nine papers of which six are treated in the thesis summary.

     

    List of papers
    1. Evaluation of a Blade Force Measurement System for a Vertical Axis Wind Turbine Using Load Cells
    Open this publication in new window or tab >>Evaluation of a Blade Force Measurement System for a Vertical Axis Wind Turbine Using Load Cells
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    2015 (English)In: Energies, ISSN 1996-1073, Vol. 8, no 6, 5973-5996 p.Article in journal (Refereed) Published
    Abstract [en]

    Unique blade force measurements on an open site straight-bladed vertical axis wind turbine have been performed. This paper presents a method for measuring the tangential and normal forces on a 12-kW vertical axis wind turbine prototype with a three-bladed H-rotor. Four single-axis load cells were installed in-between the hub and the support arms on one of the blades. The experimental setup, the measurement principle, together with the necessary control and measurement system are described. The maximum errors of the forces and accompanying weather data that can be obtained with the system are carefully estimated. Measured forces from the four load cells are presented, as well as the normal and tangential forces derived from them and a comparison with theoretical data. The measured torque and bending moment are also provided. The influence of the load cells on the turbine dynamics has also been evaluated. For the aerodynamic normal force, the system provides periodic data in agreement with simulations. Unexpected mechanical oscillations are present in the tangential force, introduced by the turbine dynamics. The measurement errors are of an acceptable size and often depend on the measured variable. Equations are presented for the calculation of measurement errors.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-260148 (URN)10.3390/en8065973 (DOI)000357489700067 ()
    Available from: 2015-08-17 Created: 2015-08-17 Last updated: 2017-10-18Bibliographically approved
    2. Frequency analysis of tangential force measurements on a vertical axis wind turbine
    Open this publication in new window or tab >>Frequency analysis of tangential force measurements on a vertical axis wind turbine
    2016 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    This paper presents experimental results of the torque ripple obtained from a three bladed 12 kW experimental H-rotor prototype. The measurements are performed by means of load cells installed on the base of the struts and by electrical measurements on the generator. The resulting torques are analysed in terms of frequency spectrum and order spectrum (synchronized with rotation). The measurements are compared to aerodynamic simulations of the turbine. The expected large torque ripple at three times the rotational speed (3 p) is only weakly represented at the hub and in the generator. This suggests that the system is filtering the ripple and/or that the simulations are overestimating the 3 p component. The torque ripple loads on the drive train are therefore lower than anticipated. Even if highly attenuated, most of the low frequencies correlating to aerodynamics are still represented in the generator electrical torque. Given a certain baseline, this opens for possible online monitoring of unbalances in the turbine by electrical measurements.

    Keyword
    wind power, vertical axis wind turbine, forces
    National Category
    Other Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-306558 (URN)10.1088/1742-6596/753/4/042016 (DOI)
    Conference
    The 6th international conference on “The Science of Making Torque from Wind”, Munich, October 5-7, 2016.
    Available from: 2016-10-28 Created: 2016-10-28 Last updated: 2017-10-18
    3. Mechanical torque ripple from a passive diode rectifier in a 12 kW vertical axis wind turbine
    Open this publication in new window or tab >>Mechanical torque ripple from a passive diode rectifier in a 12 kW vertical axis wind turbine
    2017 (English)In: IEEE transactions on energy conversion, ISSN 0885-8969, E-ISSN 1558-0059, Vol. 32, no 1, 164-171 p.Article in journal (Refereed) Published
    Abstract [en]

    The influence of passive rectification on the mechanical torque of a permanent magnet generator for a directly driven vertical axis wind turbine has been studied. Passive diode rectification introduce electromagnetic torque ripple from the generator. The conversion of electromagnetic torque ripple into mechanical torque ripple and rotational speed ripple has been modeled, analytically evaluated, and simulated. The simulations have been compared to measurements on an open site 12 kW prototype. A parameter study with the model illustrates the impact of shaft torsional spring constant, generator rotor inertia, generator inductance, and dc-link capacitance. The results show that the shaft and generator rotor can be an effective filter of electromagnetic torque ripple from diode rectification. The measured mechanical torque ripple amplitude on the prototype is less than +/- 0.9% of nominal turbine torque. The measurements compare well with the simulations.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-272363 (URN)10.1109/TEC.2016.2626783 (DOI)000396130300016 ()
    Available from: 2016-01-13 Created: 2016-01-13 Last updated: 2017-10-18Bibliographically approved
    4. Critical Speed Control for a Fixed Blade Variable Speed Wind Turbine
    Open this publication in new window or tab >>Critical Speed Control for a Fixed Blade Variable Speed Wind Turbine
    2017 (English)In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 10, no 11, 1699Article in journal (Refereed) Published
    Abstract [en]

    A critical speed controller for avoiding a certain rotational speed is presented. The controller is useful for variable speed wind turbines with a natural frequency in the operating range. The controller has been simulated, implemented and tested on an open site 12 kW vertical axis wind turbine prototype. The controller is based on an adaptation of the optimum torque control. Two lookup tables and a simple state machine provide the control logic of the controller. The controller requires low computational resources, and no wind speed measurement is needed. The results suggest that the controller is a feasible method for critical speed control. The skipping behavior can be adjusted using only two parameters. While tested on a vertical axis wind turbine, it may be used on any variable speed turbine with the control of generator power.

    Keyword
    vertical axis wind turbine, variable speed, control, optimal torque, critical speed, speed exclusion zone, natural frequencies, eigenfrequencies
    National Category
    Energy Systems
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-331782 (URN)10.3390/en10111699 (DOI)
    Funder
    StandUpStandUp for Wind
    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-26
    5. Multiple Vertical Axis Wind Turbines with Passive Rectification to a Common DC-link
    Open this publication in new window or tab >>Multiple Vertical Axis Wind Turbines with Passive Rectification to a Common DC-link
    (English)Manuscript (preprint) (Other academic)
    National Category
    Energy Systems
    Identifiers
    urn:nbn:se:uu:diva-331784 (URN)
    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-26
    6. Force measurements on a VAWT blade in parked conditions
    Open this publication in new window or tab >>Force measurements on a VAWT blade in parked conditions
    (English)Manuscript (preprint) (Other academic)
    National Category
    Energy Systems
    Identifiers
    urn:nbn:se:uu:diva-331818 (URN)
    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-18
    7. Measurements of the Aerodynamic Normal Forces on a 12-kW Straight-Bladed Vertical Axis Wind Turbine
    Open this publication in new window or tab >>Measurements of the Aerodynamic Normal Forces on a 12-kW Straight-Bladed Vertical Axis Wind Turbine
    2015 (English)In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 8, no 8Article in journal (Refereed) Published
    Abstract [en]

    The knowledge of unsteady forces is necessary when designing vertical axis wind turbines (VAWTs). Measurement data for turbines operating at an open site are still very limited. The data obtained from wind tunnels or towing tanks can be used, but have limited applicability when designing large-scale VAWTs. This study presents experimental data on the normal forces of a 12-kW straight-bladed VAWT operated at an open site north of Uppsala, Sweden. The normal forces are measured with four single-axis load cells. The data are obtained for a wide range of tip speed ratios: from 1.7 to 4.6. The behavior of the normal forces is analyzed. The presented data can be used in validations of aerodynamic models and the mechanical design for VAWTs.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-260569 (URN)10.3390/en8088482 (DOI)000360586600052 ()
    Available from: 2015-08-20 Created: 2015-08-20 Last updated: 2017-10-18Bibliographically approved
    8. Permanent Magnet Working Point Ripple in Synchronous Generators
    Open this publication in new window or tab >>Permanent Magnet Working Point Ripple in Synchronous Generators
    2017 (English)In: The Journal of Engineering, ISSN 1872-3284, E-ISSN 2051-3305, 1-8 p.Article in journal (Refereed) Accepted
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Electronics
    Identifiers
    urn:nbn:se:uu:diva-303518 (URN)10.1049/joe.2016.0309 (DOI)000398521800001 ()
    Funder
    Swedish Research Council, 2010-3950Carl Tryggers foundation , 15:152
    Available from: 2016-10-19 Created: 2016-09-20 Last updated: 2017-10-18
    9. Designing, simulations and experiments of a passive permanent magnet bearing
    Open this publication in new window or tab >>Designing, simulations and experiments of a passive permanent magnet bearing
    Show others...
    2016 (English)In: International journal of applied electromagnetics and mechanics, ISSN 1383-5416, E-ISSN 1875-8800, Vol. 51, no 2, 131-149 p.Article in journal (Refereed) Published
    Abstract [en]

    This paper presents simulations and experimental results for two types of Passive Permanent Magnet Bearings. The bearing system under investigation consists of two permanent magnet rings opposing to each other in two different configurations. The influence of parameters, such as thickness and radius of permanent magnets, in the force is presented through FEM calculations. Two setups of passive magnetic bearings have been built. Static measurements of radial and axial forces are reported and results compared with simulations. Also, dynamic tests show the behavior of the bearing and the magnitudes of force in the foothold. The results are presented to show trends in the parameters, so the conclusions are applicable for other sizes and applications. As an example, the application as a top bearing for a 12 kW vertical axis wind turbine is considered.

    Keyword
    Permanent magnetic bearing, finite element method, vertical axis bearing
    National Category
    Applied Mechanics
    Identifiers
    urn:nbn:se:uu:diva-299628 (URN)10.3233/JAE-150162 (DOI)000377871000004 ()
    Funder
    Swedish Research CouncilStandUp
    Available from: 2016-07-25 Created: 2016-07-25 Last updated: 2017-10-18Bibliographically approved
  • Pavek, Maja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Dietary fat intake from fish and dairyproducts in adolescents assessed by the webbased dietary assessment method Riksmaten Flex: a pilot validation2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Milk and dairy products are common compounds of the Swedish diet. Fish, in particular oily fish, is recommended for health effects. Accurate dietary information on individuals diet is of great importance when studying the associations between diet and health. The National Food Agency in Sweden has developed a new web-based method, Riksmaten Flex (RF), for assessing food intake in adolescents.

    Objective: To investigate how well the web-based method Riksmaten Flex (RF) captures intake of fish and dairy products compared to 24-hour recalls. Serum concentrations of fatty acids, biomarkers for fish and dairy products, were used to investigate the reported intake of fish and dairy products from each respective method.

    Method: Participants in the age of 11-12, 14-15 and 17-18 years old were recruited from different schools in Sweden. The adolescents completed two days of dietary recordings in RF and two 24-hour recalls. Blood samples were taken and analyzed.

    Results: More girls than boys completed the study and the reported median energy intake was higher in RF compared to 24-hour recalls (p=0,005). Intake of dairy products correlated with the reported RF and 24-hour recalls. Intake of dairy products correlated significantly with pentadecanoic acid (15:0) in serum cholesterol esters and phospholipids and with heptadecaoic acid (17:0) in serum phospholipids. There was no significant correlation between fatty acids and the reported fish intake from 24-hour recalls but however for fish intake from RF and eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total n-3 fatty acids.

    Conclusion: It is concluded that weak correlations were found between the reported intake in RF, 24-hour recalls and biomarkers for fatty acids in blood. Significance of the correlations cannot be concluded due to the lack of a sample size calculation. Small number of participants, few days of registration and a large drop-out rate are some of the limitations.

  • Public defence: 2017-12-08 13:15 BMC/A1:111a, Uppsala
    Chen, Lei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Molecular Tools for Biomarker Detection2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The advance of biological research promotes the emerging of new methods and solutions to answer the biological questions. This thesis describes several new molecular tools and their applications for the detection of genomic and proteomic information with extremely high sensitivity and specificity or simplify such detection procedures without compromising the performance.

    In paper I, we described a general method namely super RCA, for highly specific counting of single DNA molecules. Individual products of a range of molecular detection reactions are magnified to Giga-Dalton levels that are easily detected for counting one by one, using methods such as low-magnification microscopy, flow cytometry, or using a mobile phone camera. The sRCA-flow cytometry readout presents extremely high counting precision and the assay’s coefficient of variation can be as low as 0.5%. sRCA-flow cytometry readout can be applied to detect the tumor mutations down to 1/100,000 in the circulating tumor cell-free DNA.

    In paper II, we applied the super RCA method into the in situ sequencing protocol to enhance the amplified mRNA detection tags for better signal-to-noise ratios. The sRCA products co-localize with primary RCA products generated from the gene specific padlock probes and remain as a single individual object in during the sequencing step. The enhanced sRCA products is 100% brighter than regular RCA products and the detection efficiency at least doubled with preserved specificity using sRCA compared to standard RCA.

    In paper III, we described a highly specific and efficient molecular switch mechanism namely RCA reporter. The switch will initiate the rolling circle amplification only in the presence of correct target sequences. The RCA reporter mechanism can be applied to recognize single stranded DNA sequences, mRNA sequences and sequences embedded in the RCA products.

    In paper IV, we established the solid phase Proximity Ligation Assay against the SOX10 protein using poly clonal antibodies. Using this assay, we found elevated SOX10 in serum at high frequency among vitiligo and melanoma patients. While the healthy donors below the threshold.

    List of papers
    1. A molecular approach for single molecule counting and rare mutation detection in blood plasma
    Open this publication in new window or tab >>A molecular approach for single molecule counting and rare mutation detection in blood plasma
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Problems in biology and medicine frequently require the ability to observe, evaluate, and count even extremely rare macromolecules directly in biological samples. Examples include the detection of mutant DNA or RNA molecules in plasma or distributed in tissues in tumor patients, and highly precise, digital enumeration of proteins and other molecules of interest in clinical specimens. We describe herein a general means to magnify detection signals from individual molecules to easily recorded levels via a highly specific process - super rolling circle amplification (sRCA). We demonstrate the ability of this technique to vastly enhance in situ detection, to count individual molecules by flow cytometry or using a mobile phone camera, and to enumerate tumor-specific sequence variants in plasma from patients at very high efficiency, with specificity adequate to detect single nucleotide mutant sequences among 100,000 copies of the normal sequence. 

    Keyword
    Rolling circle amplification, cfDNA, single molecule, digital counting, rare mutation detection, PoC application
    National Category
    Genetics
    Identifiers
    urn:nbn:se:uu:diva-331737 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-17
    2. Profiling and genotyping individual mRNA molecules through in situ sequencing of super rolling circle amplification products
    Open this publication in new window or tab >>Profiling and genotyping individual mRNA molecules through in situ sequencing of super rolling circle amplification products
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    We have recently developed a technology for localized sequence library preparation with rolling-circle amplification (RCA) as an approach for in situ sequencing. This method involves generation of clonally amplified and specially confined substrates for next-generation sequencing within the preserved context of cells and tissues. Our approach combines padlock probing, RCA, and sequencing-by-ligation chemistry that can resolve expression profiles of sets of genes and mutations in tissues without loss of histological context. Like other fluorescence-based assays, it can be hindered by high level of background fluorescence. To achieve high signal-to-noise ratios, we now describe a method to boost the amplification generated by RCA of padlock probes in situ by super RCA (sRCA). In this technique, a second padlock probe is hybridized, ligated and amplified on the first RCA product for enhanced, localized amplification. We describe and compare different sRCA strategies where gap-fill ligation was showed to be most efficient. The sRCA products co-localize and have comparable sizes as RCA products but they display at least two fold higher signal intensity. This increase in signal to noise also proved to result in two folds increase in the number of sRCA products detected. By combining sRCA with in situ sequencing for highly multiplex detection in tissue a four-time increase was seen. In summary, we demonstrate that sRCA can significantly increase the performance of padlock-based in situ sequencing for gene expression profiling of tissue sections, enabling detection of low abundant transcripts and the analysis of also highly auto-fluorescent samples. 

    Keyword
    in situ sequencing; super RCA (sRCA); tissue gene expression profiling, gap-fill padlock probe
    National Category
    Genetics
    Identifiers
    urn:nbn:se:uu:diva-331741 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-17
    3. Rolling Circle Amplification (RCA) Reporters – a new generic tool for the detection of DNA, RNA and proteins
    Open this publication in new window or tab >>Rolling Circle Amplification (RCA) Reporters – a new generic tool for the detection of DNA, RNA and proteins
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Many methods to detect biomolecules with rolling circle amplification (RCA), for example padlock probes and proximity ligation assay (PLA), are tedious and includes several reaction steps combined with long incubation times. The present investigation evaluates a new tool to be included in the toolbox of RCA based detection methods that we refer to as RCA Reporter. The main idea with the RCA Reporter is to use pre-ligated circles protected from RCA initiation by almost entire hybridization to a protector molecule that unlocks through a well characterized and highly specific strand displacement process. The RCA Reporters are a generic tool that can be used to directly detect ssDNA or RNA in a sample, to detect proteins via coupling to proximity recognition using a pair of antibodies or to further amplify ongoing RCA reactions. The latter can be used to allow for efficient digital readout of single molecules via flow cytometry with the potential to develop simple and highly accurate molecular counting assays.

    National Category
    Genetics
    Identifiers
    urn:nbn:se:uu:diva-331743 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-10-17
    4. Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay
    Open this publication in new window or tab >>Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay
    Show others...
    2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 4, e0154214Article in journal (Refereed) Published
    Abstract [en]

    Background

    The diagnosis of malignant melanoma currently relies on clinical inspection of the skin surface and on the histopathological status of the excised tumor. The serum marker S100B is used for prognostic estimates at later stages of the disease, but analyses are marred by false positives and inadequate sensitivity in predicting relapsing disorder.

    Objectives

    To investigate SOX10 as a potential biomarker for melanoma and vitiligo.

    Methods

    In this study we have applied proximity ligation assay (PLA) to detect the transcription factor SOX10 as a possible serum marker for melanoma. We studied a cohort of 110 melanoma patients. We further investigated a second cohort of 85 patients with vitiligo, which is a disease that also affects melanocytes.

    Results

    The specificity of the SOX10 assay in serum was high, with only 1% of healthy blood donors being positive. In contrast, elevated serum SOX10 was found with high frequency among vitiligo and melanoma patients. In patients with metastases, lack of SOX10 detection was associated with treatment benefit. In two responding patients, a change from SOX10 positivity to undetectable levels was seen before the response was evident clinically.

    Conclusions

    We show for the first time that SOX10 represents a promising new serum melanoma marker for detection of early stage disease, complementing the established S100B marker. Our findings imply that SOX10 can be used to monitor responses to treatment and to assess if the treatment is of benefit at stages earlier than what is possible radiologically.

    Keyword
    sox10 proximity ligation assay
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-289194 (URN)10.1371/journal.pone.0154214 (DOI)000374970600050 ()27110718 (PubMedID)
    Funder
    EU, FP7, Seventh Framework Programme, 294409EU, FP7, Seventh Framework Programme, 316929Swedish Research Council
    Available from: 2016-04-29 Created: 2016-04-29 Last updated: 2017-10-17Bibliographically approved
  • Blix, Stina
    Stockholms universitet, Sociologiska institutionen.
    Skådespelarens yrkeskunnande: en fenomenologisk studie2004In: Sociologisk forskning, ISSN 0038-0342, no 1, 37-56 p.Article in journal (Refereed)
    Abstract [en]

    Six theatre actors of both sexes differing in education and length of experience were interviewed individually on their professional competence. Phenomenological reduction generated six fundamental constituents of the actors' professional competence interpreted in terms of a ”wheel model”: mastery of technical skills such as being able to control one’s voice and one's body; daring to approach each new role with an open mind; being able to work effectively with co-actors in an ensemble; having a capacity for a high degree of empathy; being able to keep one’s professional and private life separate; doing one’s best at each performance. Each constituent was seen as contributing to the essence of an actor’s skill - the ability to make a role figure come alive. Similarities and differences compared with other professions are pointed out. The significance of daring to have an open mind, that is of encountering personal emotions, such as early experiences of emotional significance, in the "front region", when studying a new role together with the director and with co-actors, is emphasized.

  • Bergman Blix, Stina
    Stockholms universitet, Sociologiska institutionen.
    Professional emotion management as a rehearsal process2015In: Professions & Professionalism, ISSN 1893-1049, E-ISSN 1893-1049, Vol. 5, no 2, 1-15 p.Article in journal (Refereed)
    Abstract [en]

    The work of stage actors has long been used as a simile for every day role playing, generating theoretical concepts to describe how people work to pre-sent themselves in general and how they manage their emotions in particular. Building on this tradition, this article analyses professional stage actors’ deliberate emotion management as an embodied professionalisation process, focusing the relation between emotional experience and expression through the concepts of decoupling, double agency and habituation. Observations and interviews with thea-tre actors rehearsing for a role revealed how they gradually develop a capacity for double agency, decoupling the experience from the expression of emotions, which are eventually habituated in a form adapted to the role character. This process of professionalising emotion management is beneficial to the presentation of role-appropriate emotions and furthers the ability to cope with the endeavour of manag-ing emotions at work. Implications for professions outside the artistic domain are discussed.

  • Bergman Blix, Stina
    Stockholms universitet, Sociologiska institutionen.
    Emotional Participation: the use of the observer’s emotions as a methodological tool when studying professional stage actors rehearsing a role for the stage2009In: Nordic Theatre Studies, ISSN 0904-6380, E-ISSN 2002-3898, Vol. 21, 29-38 p.Article in journal (Refereed)
    Abstract [en]

    This contribution aims to identify and clarify emotional aspects of conducting observation studies. The researcher, in most cases, does not want to interfere with or influence the phenomenon under observation, but uses her/himself as a tool to collect material. Even if the observer does not participate verbally, s/he can be emotionally participative using her/his emotions as a methodological tool, generating reflections and insights relative to the situations and persons that are the object of observation. Earlier contributions from social anthropology and psychotherapy are discussed and compared to examples from observations on the rehearsals of two theatre productions. One crucial point is that the researcher’s emotions can be more or less congruent with the situation at hand; a match as well as a mis-match can be used as information in the research process. Furthermore, the emotional expressions displayed by professional actors can be more or less emotionally anchored within them. Do the observer’s feelings correlate with the research subjects’ felt emotions or their portrayed emotions? Reflections on these issues can be used in interviews with research subjects to attain a more nuanced and tangible interpretation of the studied phenomenon.

  • de Lhoneux, Miryam
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Stymne, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Nivre, Joakim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Arc-Hybrid Non-Projective Dependency Parsing with a Static-Dynamic Oracle2017In: IWPT 2017 15th International Conference on Parsing Technologies: Proceedings of the Conference, Pisa, Italy: Association for Computational Linguistics, 2017, 99-104 p.Conference paper (Refereed)
    Abstract [en]

    We extend the arc-hybrid transition system for dependency parsing with a SWAP transition that enables reordering of the words and construction of non-projective trees. Although this extension potentially breaks the arc-decomposability of the transition system, we show that the existing dynamic oracle can be modified and combined with a static oracle for the SWAP transition. Experiments on five languages with different degrees of non-projectivity show that the new system gives competitive accuracy and is significantly better than a system trained with a purely static oracle.

  • de Lhoneux, Miryam
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Yan, Shao
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Basirat, Ali
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Kiperwasser, Eliyahu
    Bar-Ilan University.
    Stymne, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Goldberg, Yoav
    Bar-Ilan University.
    Nivre, Joakim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    From raw text to Universal Dependencies: look, no tags!2017In: Proceedings of the CoNLL 2017 Shared Task: Multilingual Parsing from Raw Text to Universal Dependencies, Vancouver, Canada: Association for Computational Linguistics, 2017, 207-217 p.Conference paper (Refereed)
    Abstract [en]

    We present the Uppsala submission to the CoNLL 2017 shared task on parsing from raw text to universal dependencies. Our system is a simple pipeline consisting of two components. The first performs joint word and sentence segmentation on raw text; the second predicts dependency trees from raw words. The parser bypasses the need for part-of-speech tagging, but uses word embeddings based on universal tag distributions. We achieved a macroaveraged LAS F1 of 65.11 in the official test run and obtained the 2nd best result for sentence segmentation with a score of 89.03. After fixing two bugs, we obtained an unofficial LAS F1 of 70.49.

  • Ward, Ashley J. W.
    et al.
    Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia..
    Schaerf, Timothy M.
    Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia.;Univ New England, Sch Sci & Technol, Armidale, NSW, Australia..
    Herbert-Read, James E.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Applied Mathematics and Statistics. Stockholm Univ, Dept Biol, Stockholm, Sweden..
    Morrell, Lesley
    Univ Hull, Sch Biol Biomed & Environm Sci, Kingston Upon Hull, N Humberside, England..
    Sumpter, David J. T.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Applied Mathematics and Statistics.
    Webster, Mike M.
    Univ St Andrews, Sch Biol, St Andrews, Fife, Scotland..
    Local interactions and global properties of wild, free-ranging stickleback shoals2017In: Royal Society Open Science, E-ISSN 2054-5703, Vol. 4, no 7, 170043Article in journal (Refereed)
    Abstract [en]

    Collective motion describes the global properties of moving groups of animals and the self-organized, coordinated patterns of individual behaviour that produce them. We examined the group-level patterns and local interactions between individuals in wild, free-ranging shoals of three-spine sticklebacks, Gasterosteus aculeatus. Our data reveal that the highest frequencies of near-neighbour encounters occur at between one and two body lengths from a focal fish, with the peak frequency alongside a focal individual. Fish also show the highest alignment with these laterally placed individuals, and generally with animals in front of themselves. Furthermore, fish are more closely matched in size, speed and orientation to their near neighbours than to more distant neighbours, indicating local organization within groups. Among the group-level properties reported here, we find that polarization is strongly influenced by group speed, but also the variation in speed among individuals and the nearest neighbour distances of group members. While we find no relationship between group order and group size, we do find that larger groups tend to have lower nearest neighbour distances, which in turn may be important in maintaining group order.

  • Kurtenbach, Stefan
    et al.
    Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany..
    Giessl, Andreas
    Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, D-91058 Erlangen, Germany..
    Strömberg, Siv
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Molecular Cell Biology.
    Kremers, Jan
    Univ Hosp Erlangen, Dept Ophthalmol, D-91054 Erlangen, Germany.;Friedrich Alexander Univ Erlangen Nurnberg, Dept Anat 2, D-91054 Erlangen, Germany..
    Atorf, Jenny
    Univ Hosp Erlangen, Dept Ophthalmol, D-91054 Erlangen, Germany..
    Rasche, Sebastian
    Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany..
    Neuhaus, Eva M.
    Univ Hosp Jena, Dept Pharmacol & Toxikol, D-07747 Jena, Germany..
    Herve, Denis
    Univ Paris 06, Inst Fer Moulin, INSERM, UMR S839, F-75005 Paris, France..
    Brandstaetter, Johann Helmut
    Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, D-91058 Erlangen, Germany..
    Asan, Esther
    Univ Wurzburg, Inst Anat & Cell Biol, D-97070 Wurzburg, Germany..
    Hatt, Hanns
    Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany..
    Kilimann, Manfred W
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Molecular Cell Biology. Max Planck Inst Expt Med, Dept Mol Neurobiol, Gottingen, Germany.
    The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 8409Article in journal (Refereed)
    Abstract [en]

    BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause severe immune deficiency. Here, we report a first functional and molecular phenotype outside the immune system of LRBA-knockout mice: compromised olfaction, manifesting in reduced electro-olfactogram response amplitude, impaired food-finding efficiency, and smaller olfactory bulbs. LRBA is prominently expressed in olfactory and vomeronasal chemosensory neurons of wild-type mice. Olfactory impairment in the LRBA-KO is explained by markedly reduced concentrations (20-40% of wild-type levels) of all three subunits alpha(olf), beta(1) and gamma(13) of the olfactory heterotrimeric G-protein, G(olf), in the sensory cilia of olfactory neurons. In contrast, cilia morphology and the concentrations of many other proteins of olfactory cilia are not or only slightly affected. LRBA is also highly expressed in photoreceptor cells, another cell type with a specialized sensory cilium and heterotrimeric G-protein-based signalling; however, visual function appeared unimpaired by the LRBA-KO. To our knowledge, this is the first observation that a BEACH protein is required for the efficient subcellular localization of a lipid-anchored protein, and of a ciliary protein.

  • Goryashko, Vitaliy A.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Quasi-half-cycle pulses of light from a tapered undulator2017In: PHYSICAL REVIEW ACCELERATORS AND BEAMS, ISSN 2469-9888, Vol. 20, no 8, 080703Article in journal (Refereed)
    Abstract [en]

    Strong-field few-cycle terahertz (THz) pulses are an invaluable tool for engineering highly non-equilibrium states of matter. A scheme is proposed to generate quasi-half-cycle GV/m-scale THz pulses with a multikilohertz repetition rate. It makes use of coherent spontaneous emission from a prebunched electron beam traversing an optimally tapered undulator. The scheme is the further development of the slippage control in free-electron lasers [T. Tanaka, Phys. Rev. Lett. 114, 044801 (2015)]. An explicit condition for the spectral amplitude of undulator radiation and a phase condition for the electron density distribution, required for the generation of desired pulses, are presented. The amplitude condition is met by proper undulator tapering, and a generic optimal undulator profile is found analytically. In order to meet the phase condition, the distance between the adjacent bunches is varied according to the instantaneous resonant undulator wavelength. A 3D analytical theory is complemented by a detailed numerical study based on a direct solution to the 3D wave equation.

  • Dareiotis, Konstantinos
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Probability Theory.
    Symmetrization of exterior parabolic problems and probabilistic interpretation2017In: STOCHASTICS AND PARTIAL DIFFERENTIAL EQUATIONS-ANALYSIS AND COMPUTATIONS, ISSN 2194-0401, Vol. 5, no 1, 38-52 p.Article in journal (Refereed)
    Abstract [en]

    We prove a comparison theorem for the spatial mass of the solutions of two exterior parabolic problems, one of them having symmetrized geometry, using approximation of the Schwarz symmetrization by polarizations, as it was introduced in Brock and Solynin (TransAmMath Soc 352(4): 1759-1796, 2000). This comparison provides an alternative proof, based on PDEs, of the isoperimetric inequality for the Wiener sausage, which was proved in Peres and Sousi (Geom Funct Anal 22(4): 10001014, 2012).

  • Journath, Gunilla
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Cardiol Unit, Stockholm, Sweden..
    Hambraeus, Kristina
    Falun Cent Hosp, Dept Cardiol, Falun, Sweden..
    Hagström, Emil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Pettersson, Billie
    Amgen Inc, Thousand Oaks, CA 91320 USA..
    Lothgren, Mickael
    Amgen Europe GmbH, Zug, Switzerland..
    Predicted impact of lipid lowering therapy on cardiovascular and economic outcomes of Swedish atherosclerotic cardiovascular disease guideline2017In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 17, 224Article in journal (Refereed)
    Abstract [en]

    Background: The effects on cardiovascular disease (CVD) by treatment recommendations on prevention of atherosclerotic CVD remain to be evaluated. The objectives were to assess treatment gap for low density lipoprotein cholesterol (LDL-C) according to guidelines, potential impact on CVD outcomes, and possible avoided economic costs, in post myocardial infarction (MI) patients, if target LDL-C levels of <= 1.8 mmol/L would be achieved. Methods: All patients registered in the Swedish Secondary Prevention after Heart Intensive care Admission register, with one-year post-MI follow-up during 2013 were selected. The REACH risk prediction and a calibrated model for recurrent cardiovascular events and death were used to estimate unadjusted risk prediction based on the REACH equation henceforth called base case, and calibrated CVD outcomes based on gender-specific risk factors. The predicted impact of the LDL-C reduction on the risk of CVD was based on the Cholesterol Treatment Trialists' Collaboration findings. Results: A sample of n = 5904 patients (74% men) with a mean age of 64 years were included. Around 70% did not reach LDL-C target = 1.8 mmol/L. Over a 10-year period, 820-2262 events were predicted to occur in those who did not reach target corresponding to 20%-55% risk of CVD events. To achieve LDL-C target, the mean LDL-C had to be reduced by 0.73 mmol/L (29%). If this LDL-C reduction was achieved, 195-544 life years, 132-343 CVD events, and 7.9-20.9 million Swedish crowns (MSEK) of direct costs, and 19.3-51.0 MSEK of total costs would be avoided. Conclusion: Lowering of LDL cholesterol to achieve target levels according to guidelines for post-MI patients may lead to fewer cardiovascular events and avoidance of event costs.

  • Public defence: 2017-12-04 13:15 Room 80101, Uppsala
    Elamalayil Soman, Deepak
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Multilevel Power Converters with Smart Control for Wave Energy Conversion2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The main focus of this thesis is on the power electronic converter system challenges associated with the grid integration of variable-renewable-energy (VRE) sources like wave, marine current, tidal, wind, solar etc. Wave energy conversion with grid integration is used as the key reference, considering its high energy potential to support the future clean energy requirements and due the availability of a test facility at Uppsala University. The emphasis is on the DC-link power conditioning and grid coupling of direct driven wave energy converters (DDWECs). The DDWEC reflects the random nature of its input energy to its output voltage wave shape. Thereby, it demands for intelligent power conversion techniques to facilitate the grid connection.

    One option is to improve and adapt an already existing, simple and reliable multilevel power converter technology, using smart control strategies. The proposed WECs to grid interconnection system consists of uncontrolled three-phase rectifiers, three-level boost converter(TLBC) or three-level buck-boost converter (TLBBC) and a three-level neutral point clamped (TLNPC) inverter. A new method for pulse delay control for the active balancing of DC-link capacitor voltages by using TLBC/TLBBC is presented. Duty-ratio and pulse delay control methods are combined for obtaining better voltage regulation at the DC-link and for achieving higher controllability range. The classic voltage balancing problem of the NPC inverter input, is solved efficiently using the above technique. A synchronous current compensator is used for the NPC inverter based grid coupling. Various results from both simulation and hardware testing show that the required power conditioning and power flow control can be obtained from the proposed multilevel multistage converter system.

    The entire control strategies are implemented in Xilinx Virtex 5 FPGA, inside National Instruments’ CompactRIO system using LabVIEW. A contour based dead-time harmonic analysis method for TLNPC and the possibilities of having various interconnection strategies of WEC-rectifier units to complement the power converter efforts for stabilizing the DC-link, are also presented. An advanced future AC2AC direct power converter system based on Modular multilevel converter (MMC) structure developed at Siemens AG is presented briefly to demonstrate the future trends in this area.

    List of papers
    1. Control and Implementation of Three Level BoostConverter for Load Voltage Regulation
    Open this publication in new window or tab >>Control and Implementation of Three Level BoostConverter for Load Voltage Regulation
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    2013 (English)In: Industrial Electronics Society, IECON 2013 - 39th Annual Conference of the IEEE, IEEE conference proceedings, 2013, 561-565 p.Conference paper, Published paper (Refereed)
    Abstract [en]

       The multilevel converters offer significant advantages for high power applications. The use of multilevel DC/DC converters provides improved efficiency for power conversion and transmission at high voltage. This paper investigates the control and implementation of a three level boost converter for regulating the load voltages. A PI controller based switch signal phase delay control (SSPDC) method is used for adjusting the load voltages at equal turn on and turn off time of the converter switches. The circuit simulation is done in Matlab/Simulink. The controller is realized by using the FPGA in Labview/Compact-Rio module. Software waiting loop length control technique is used for implementing the switch signal delay control. The hardware circuit is implemented and tested. The results show a validation of the controller for regulating the voltages. This method can easily be applied for voltage balancing in a three level neutral point clamped inverter where neutral voltage imbalance is always an issue.

    Place, publisher, year, edition, pages
    IEEE conference proceedings, 2013
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-218177 (URN)10.1109/IECON.2013.6699196 (DOI)
    Conference
    39th Annual Conference of the IEEE Industrial Electronics Society, IECON 2013
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2014-02-09 Created: 2014-02-09 Last updated: 2017-11-01
    2. Pulse delay Control for Capacitor VoltageBalancing in a Three Level Boost Neutral PointClamped Inverter
    Open this publication in new window or tab >>Pulse delay Control for Capacitor VoltageBalancing in a Three Level Boost Neutral PointClamped Inverter
    2015 (English)In: IET Power Electronics, ISSN 1755-4543, Vol. 8, no 2, 268-277 p.Article in journal (Refereed) Published
    Abstract [en]

    The cross regulation effect in multi-output DC/DC converters offers a reliable support for the grid integration of multilevel inverters by balancing the capacitor voltages. The capacitor voltage balancing by single input dual output boost converter is often realised by conventional three-level switching scheme. The three-level operation benefits lower inductor ripple current, but it limits the maximum possible compensation voltages. In this study, the entire operating modes of the boost converter is presented and all the possible cases which contribute to the voltage balancing are employed for balancing the capacitor voltages in a three-level neutral point clamped inverter. A proportional-integral controller based duty ratio control and pulse delay control are used for DC link voltage regulation and capacitor voltage balancing. Since the classical state-space averaging technique is not suitable for SIDO converters, inductor current ripple averaging technique is utilised for controller design. The circuit simulation is performed in Matlab/Simulink. The digital controller is realised using the Virtex-5FPGA in Labview/CompactRIO module. Both simulation and experimental results are presented to validate the controller performance.

    Keyword
    invertors, DC-DC power convertors, PI control, control system synthesis, field programmable gate arrays, digital control, virtual instrumentation, voltage control, delays, pulse delay control, capacitor voltage balancing, three level boost neutral point clamped inverter, multioutput DC-DC converters, cross regulation effect, grid integration, single input dual output boost converter, three-level switching scheme, inductor ripple current, proportional-integral controller, DC link voltage regulation, state-space averaging technique, inductor current ripple averaging technique, controller design, Matlab, Simulink, digital controller, Vertex 5-FPGA, Labview-Compact-Rio module
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-218163 (URN)10.1049/iet-pel.2014.0103 (DOI)000349535400011 ()
    Available from: 2014-02-09 Created: 2014-02-09 Last updated: 2017-11-01Bibliographically approved
    3. Discontinuous conduction mode of a three-level boost DC-DC converter and its merits and limits for voltage cross regulation applications
    Open this publication in new window or tab >>Discontinuous conduction mode of a three-level boost DC-DC converter and its merits and limits for voltage cross regulation applications
    Show others...
    2014 (English)In: Industrial Electronics Society, IECON 2014 - 40th Annual Conference of the IEEE, IEEE conference proceedings, 2014, 4268-4272 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    Distributed generation and smart grid integration of renewable energy sources introduce a lot of challenges for the enabling power electronic converter technology. Some of these challenges include wide controllability range, high power handling and good reliability. Three-level boost converter is one of the attractive solution for applications requiring voltage cross regulation such as three-level neutral point clamped inverter based grid integration of renewable sources. The present work shows the advantages and disadvantages of using discontinuous conduction mode of a Three-level boost converter for voltage cross regulation. The converter working principle, modes of operation and operating cases are listed briefly. The simulation results compare the DCM and CCM cross regulation effects. Based on these results, the controllability range of the converter is analyzed to understand the suitability of the converter for various applications.

    Place, publisher, year, edition, pages
    IEEE conference proceedings, 2014
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-253956 (URN)10.1109/IECON.2014.7049144 (DOI)
    Conference
    Industrial Electronics Society, IECON 2014 - 40th Annual Conference of the IEEE
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2015-06-04 Created: 2015-06-04 Last updated: 2017-11-01
    4. Cross-Regulation Assessment of DIDO Buck-BoostConverter for Renewable Energy Application
    Open this publication in new window or tab >>Cross-Regulation Assessment of DIDO Buck-BoostConverter for Renewable Energy Application
    2017 (English)In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 10Article in journal (Refereed) Published
    Abstract [en]

    When medium- or high-voltage power conversion is preferred for renewable energy sources, multilevel power converters have received much of the interest in this area as methods for enhancing the conversion efficiency and cost effectiveness. In such cases, multilevel, multi-input multi-output (MIMO) configurations of DC-DC converters come to the scenario for integrating several sources together, especially considering the stringent regulatory needs and the requirement of multistage power conversion systems. Considering the above facts, a three-level dual input dual output (DIDO) buck-boost converter, as the simplest form of MIMO converter, is proposed in this paper for DC-link voltage regulation. The capability of this converter for cross regulating the DC-link voltage is analyzed in detail to support a three-level neutral point clamped inverter-based grid connection in the future. The cross-regulation capability is examined under a new type of pulse delay control (PDC) strategy and later compared with a three-level boost converter (TLBC). Compared to conventional boost converters, the high-voltage three-level buck boost converter (TLBBC) with PDC exhibits a wide controllability range and cross regulation capability. These enhanced features are extremely important for better regulating variable output renewable energy sources such as solar, wind, wave, marine current, etc. The simulation and experimental results are provided to validate the claim.

    Keyword
    dual input dual output (DIDO) converter; three-level buck boost converter (TLBBC); pulse delay control (PDC); neutral point clamped inverter; cross-regulation; renewable energy conversion
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-332725 (URN)10.3390/en10070846 (DOI)
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2017-11-01 Created: 2017-11-01 Last updated: 2017-11-01
    5. Analysis of Three-level Buck-Boost Converter Operation for Improved Renewable Energy Conversion and Smart Grid Integration
    Open this publication in new window or tab >>Analysis of Three-level Buck-Boost Converter Operation for Improved Renewable Energy Conversion and Smart Grid Integration
    Show others...
    2014 (English)In: 2014 IEEE International Energy Conference (ENERGYCON 2014), IEEE conference proceedings, 2014, 76-81 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    The increased smart grid integration of renewable energy sources demands high power handling and wide controllability for the enabling power conversion technologies. The conventional energy conversion techniques are inadequate to efficiently handle the highly varying nature of renewable energy sources like wave, solar, tidal and wind. The present work examines the advantages of using a three-level buck-boost DC-DC converter to aid three-level neutral-point-clamped inverter based grid integration. There are two main reasons for using this converter. It can provide the conventional buck-boost capability at higher power levels for absorbing and conditioning the renewable source output. Besides, it can be used as a voltage balancing device to satisfy the input requirement for the three-level neutral-point-clamped inverter. The work includes complete operating range analysis of the converter for the combined buck-boost action and voltage balancing effects to understand its suitability for various applications. The converter switching modes of operation are also presented in detail along with essential example waveforms. The final results show good controllability bandwidth for the converter which makes it an attractive solution for smart grid integration of renewable energy sources.

    Place, publisher, year, edition, pages
    IEEE conference proceedings, 2014
    Series
    IEEE International Energy Conference, ISSN 2164-4322 ; 76-81
    Keyword
    Three-level buck-boost converter, Renewable energy conversion, Smart grid integration, Neutral-point-clamped inverter
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-240677 (URN)10.1109/ENERGYCON.2014.6850409 (DOI)000343646400013 ()978-1-4799-2449-3 (ISBN)
    Conference
    IEEE International Energy Conference (ENERGYCON), MAY 13-16, 2014, Dubrovnik, CROATIA
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2017-11-01
    6. Contour-Based Dead-Time Harmonic Analysis in a Three-Level Neutral-Point-Clamped Inverter
    Open this publication in new window or tab >>Contour-Based Dead-Time Harmonic Analysis in a Three-Level Neutral-Point-Clamped Inverter
    2015 (English)In: IEEE transactions on industrial electronics (1982. Print), ISSN 0278-0046, E-ISSN 1557-9948, Vol. 62, no 1, 203-210 p.Article in journal (Refereed) Published
    Abstract [en]

    The term dead time refers to a prime safety factor for most power electronic converter topologies, and it is included either in the control software or in the gate/base driver hardware, depending on the application as well as the control requirements. In this paper, the authors present a comprehensive numerical analysis of dead-time effects on the output voltage of a three-level neutral-pointclamped (NPC) inverter. To incorporate the dead-time effect in the output voltage, 3-D models of three-level carrier pulse width modulation (PWM) methods are modified for two dead-time implementations. Closed-form expressions of inverter phase voltage harmonics for phase opposition disposition (POD) PWM are derived based on the double Fourier series approach and modified contour plots. The harmonic spectra from numerical evaluations, simulations, and experiments for natural sampling (NS), symmetrical regular sampling (SRS), and asymmetrical regular sampling (ARS) are compared to validate the mathematical models. In addition, the fundamental voltage with respect to the dead time and the load phase angle is presented based on analytical results and simulation.

    Place, publisher, year, edition, pages
    IEEE, 2015
    Keyword
    DC–AC power conversion, dead time, neutral-point-clamped (NPC) inverter, pulse width modulation (PWM), voltage harmonics
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-218169 (URN)10.1109/TIE.2014.2327579 (DOI)000346767400022 ()
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy StorageSwedish Energy AgencyStandUp
    Available from: 2014-02-09 Created: 2014-02-09 Last updated: 2017-11-01Bibliographically approved
    7. Synchronous Current Compensator for a Self Balanced Three-Level Neutral Point Clamped Inverter
    Open this publication in new window or tab >>Synchronous Current Compensator for a Self Balanced Three-Level Neutral Point Clamped Inverter
    2014 (English)In: Advances in Power Electronics, ISSN 2090-181X, E-ISSN 2090-1828, 620607Article in journal (Refereed) Published
    Abstract [en]

    This paper presents a synchronous current control method for a three-level neutral point clamped inverter. Synchronous reference frame control based on two decoupled proportional-integral (PI) controllers is used to control the current in direct and quadrature axes. A phase disposition pulse width modulation (PDPWM) method in regular symmetrical sampling is used for generating the inverter switching signals. To eliminate the harmonic content with no phase errors, two first-order low pass filters (LPFs) are used for the dq currents. The simulation of closed-loop control is done in Matlab/Simulink. The Vertex-5 field programmable gate array (FPGA) in Labview/CompactRio is used for the implementation of the control algorithm. The control and switch pulse generation are done in independent parallel loops. The synchronization of both loops is achieved by controlling the length of waiting time for each loop. The simulation results are validated with experiments. The results show that the control action is reliable and efficient for the load current control.

    Place, publisher, year, edition, pages
    Hindawi Publishing Corporation, 2014
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-218168 (URN)10.1155/2014/620607 (DOI)
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2014-02-09 Created: 2014-02-09 Last updated: 2017-11-01
    8. DC-Link Stress Analysis for the Grid Connection of Point Absorber Type Wave Energy Converters
    Open this publication in new window or tab >>DC-Link Stress Analysis for the Grid Connection of Point Absorber Type Wave Energy Converters
    2015 (English)In: 2015 International Conference On Clean Electrical Power (ICCEP), 2015, 61-66 p.Conference paper, Oral presentation only (Refereed)
    Abstract [en]

    Highly random nature of input power from wave energy converters (WEC), especially from direct-driven point absorbers, demands customized power electronic converters for grid connection. In this paper, analysis and comparison of the DC-link stresses in the converter systems for two cases - a single and three collective units, of wave energy converters is given. The AC/DC/AC converter system includes a conventional uncontrolled three phase rectifier, a DC/DC converter to boost the DC-link voltage and an inverter with RL load. The system has been studied under two different controller actions for the DC/DC converter: with constant boost factor and with constant DC-link voltage. A Proportional Integral controller has been used to regulate the voltage in the latter case. Matlab/Simulink based system simulation has been done to compare the DC-link stress. The analysis shows the comparison in DC-link stresses and the requirements of the system for different cases, proving the advantages and the importance of having customized active power conversion methods for minimizing the DC-link stresses.

    Keyword
    DC-link stress analysis; harmonic distortion; passive rectifier; wave energy converter
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-258208 (URN)10.1109/ICCEP.2015.7177601 (DOI)000380609800010 ()9781479987047 (ISBN)
    Conference
    5th International Conference on Clean Electrical Power (ICCEP)
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2015-07-10 Created: 2015-07-10 Last updated: 2017-11-01Bibliographically approved
    9. Interconnection Strategies of Point Absorber Type Wave Energy Converters and Rectifier Units
    Open this publication in new window or tab >>Interconnection Strategies of Point Absorber Type Wave Energy Converters and Rectifier Units
    (English)Manuscript (preprint) (Other academic)
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-332728 (URN)
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2017-11-01 Created: 2017-11-01 Last updated: 2017-11-01
    10. Status Update of the Wave Energy Research at Uppsala University
    Open this publication in new window or tab >>Status Update of the Wave Energy Research at Uppsala University
    Show others...
    2013 (English)Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Aalborg, Denmark: , 2013
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-212701 (URN)
    Conference
    10th European Wave and Tidal Conference (EWTEC)
    Available from: 2013-12-13 Created: 2013-12-13 Last updated: 2017-11-01
    11. Development of Power Electronics Based Test Platform for Characterization and Testing of Magnetocaloric Materials
    Open this publication in new window or tab >>Development of Power Electronics Based Test Platform for Characterization and Testing of Magnetocaloric Materials
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    2015 (English)In: Advances in Electrical Engineering, ISSN 2356-6655, Vol. 2015, no 670624, 7- p.Article in journal (Refereed) Published
    Abstract [en]

    Magnetocaloric effects of various materials are getting more and more interesting for the future, as they can significantly contribute towards improving the efficiency of many energy intensive applications such as refrigeration, heating, and air conditioning. Accurate characterization of magnetocaloric effects, exhibited by various materials, is an important process for further studies and development of the suitable magnetocaloric heating and cooling solutions. The conventional test facilities have plenty of limitations, as they focus only on the thermodynamic side and use magnetic machines with moving bed of magnetocaloric material or magnet. In this work an entirely new approach for characterization of the magnetocaloric materials is presented, with the main focus on a flexible and efficient power electronic based excitation and a completely static test platform. It can generate a periodically varying magnetic field using superposition of an ac and a dc magnetic field. The scale down prototype uses a customized single phase H-bridge inverter with essential protections and an electromagnet load as actuator. The preliminary simulation and experimental results show good agreement and support the usage of the power electronic test platform for characterizing magnetocaloric materials.

    Place, publisher, year, edition, pages
    Hindawi Publishing Corporation, 2015
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-245221 (URN)10.1155/2015/670624 (DOI)
    Projects
    Magnetocaloric
    Available from: 2015-02-25 Created: 2015-02-25 Last updated: 2017-11-01
    12. Kalman Filter Based Grid Synchronization in Stationary Reference Frame
    Open this publication in new window or tab >>Kalman Filter Based Grid Synchronization in Stationary Reference Frame
    (English)Manuscript (preprint) (Other academic)
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-332729 (URN)
    Funder
    SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
    Available from: 2017-11-01 Created: 2017-11-01 Last updated: 2017-11-01
  • Eriksson, Daniel
    et al.
    Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden..
    Karlsson, Linda
    Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden..
    Eklund, Oskar
    Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden..
    Dieperink, Hans
    Odense Univ Hosp, Dept Nephrol, Sdr Blvd 29, DK-5000 Odense C, Denmark..
    Honkanen, Eero
    Univ Helsinki, Cent Hosp, Dept Med, Div Nephrol, Haartmaninkatu 4,POB 372, FIN-00029 Hus Helsinki, Finland..
    Melin, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
    Selvig, Kristian
    Vestre Viken Hosp Trust, Dept Nephrol, Postboks 800 3004, Drammen, Norway..
    Lundberg, Johan
    Otsuka Pharma Scandinavia, Birger Jarlsgatan 27, S-11145 Stockholm, Sweden..
    Real-world costs of autosomal dominant polycystic kidney disease in the Nordics2017In: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 17, 560Article in journal (Refereed)
    Abstract [en]

    Background: There is limited real-world data on the economic burden of patients with autosomal dominant polycystic kidney disease (ADPKD). The objective of this study was to estimate the annual direct and indirect costs of patients with ADPKD by severity of the disease: chronic kidney disease (CKD) stages 1-3; CKD stages 4-5; transplant recipients; and maintenance dialysis patients. Methods: A retrospective study of ADPKD patients was undertaken April-December 2014 in Denmark, Finland, Norway and Sweden. Data on medical resource utilisation were extracted from medical charts and patients were asked to complete a self-administered questionnaire. Results: A total of 266 patients were contacted, 243 (91%) of whom provided consent to participate in the study. Results showed that the economic burden of ADPKD was substantial at all levels of the disease. Lost wages due to reduced productivity were large in absolute terms across all disease strata. Mean total annual costs were highest in dialysis patients, driven by maintenance dialysis care, while the use of immunosuppressants was the main cost component for transplant care. Costs were twice as high in patients with CKD stages 4-5 compared to CKD stages 1-3. Conclusions: Costs associated with ADPKD are significant and the progression of the disease is associated with an increased frequency and intensity of medical resource utilisation. Interventions that can slow the progression of the disease have the potential to lead to substantial reductions in costs for the treatment of ADPKD.

  • Public defence: 2017-12-08 10:15 Room 2446, TDB, Uppsala
    Dorostkar, Ali
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Numerical Analysis.
    Analysis and Implementation of Preconditioners for Prestressed Elasticity Problems: Advances and Enhancements2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In this work, prestressed elasticity problem as a model of the so-called glacial isostatic adjustment (GIA) process is studied. The model problem is described by a set of partial differential equations (PDE) and discretized with a mixed finite element (FE) formulation. In the presence of prestress the so-constructed system of equations is non-symmetric and indefinite. Moreover, the resulting system of equations is of the saddle point form.

    We focus on a robust and efficient block lower-triangular preconditioning method, where the lower diagonal block is and approximation of the so-called Schur complement. The Schur complement is approximated by the so-called element-wise Schur complement. The element-wise Schur complement is constructed by assembling exact local Schur complements on the cell elements and distributing the resulting local matrices to the global preconditioner matrix.

    We analyse the properties of the element-wise Schur complement for the symmetric indefinite system matrix and provide proof of its quality. We show that the spectral radius of the element-wise Schur complement is bounded by the exact Schur complement and that the quality of the approximation is not affected by the domain shape.

    The diagonal blocks of the lower-triangular preconditioner are combined with inner iterative schemes accelerated by (numerically) optimal and robust algebraic multigrid (AMG) preconditioner. We observe that on distributed memory systems, the top pivot block of the preconditioner is not scaling satisfactorily. The implementation of the methods is further studied using a general profiling tool, designed for clusters.

    For nonsymmetric matrices we use the theory of Generalized Locally Toeplitz (GLT) matrices and show the spectral behavior of the element-wise Schur complement, compared to the exact Schur complement. Moreover, we use the properties of the GLT matrices to construct a more efficient AMG preconditioner. Numerical experiments show that the so-constructed methods are robust and optimal.

    List of papers
    1. Numerical and computational aspects of some block-preconditioners for saddle point systems
    Open this publication in new window or tab >>Numerical and computational aspects of some block-preconditioners for saddle point systems
    2015 (English)In: Parallel Computing, ISSN 0167-8191, E-ISSN 1872-7336, Vol. 49, 164-178 p.Article in journal (Refereed) Published
    National Category
    Computational Mathematics Computer Science
    Identifiers
    urn:nbn:se:uu:diva-253717 (URN)10.1016/j.parco.2015.06.003 (DOI)000364892500012 ()
    Available from: 2015-06-26 Created: 2015-06-01 Last updated: 2017-10-18Bibliographically approved
    2. Spectral analysis of coupled PDEs and of their Schur complements via Generalized Locally Toeplitz sequences in 2D
    Open this publication in new window or tab >>Spectral analysis of coupled PDEs and of their Schur complements via Generalized Locally Toeplitz sequences in 2D
    2016 (English)In: Computer Methods in Applied Mechanics and Engineering, ISSN 0045-7825, E-ISSN 1879-2138, Vol. 309, 74-105 p.Article in journal (Refereed) Published
    National Category
    Computational Mathematics
    Identifiers
    urn:nbn:se:uu:diva-296265 (URN)10.1016/j.cma.2016.05.042 (DOI)000383828400004 ()
    Available from: 2016-06-08 Created: 2016-06-14 Last updated: 2017-10-18Bibliographically approved
    3. Schur complement matrix and its (elementwise) approximation: A spectral analysis based on GLT sequences
    Open this publication in new window or tab >>Schur complement matrix and its (elementwise) approximation: A spectral analysis based on GLT sequences
    2015 (English)In: Large-Scale Scientific Computing, Springer, 2015, 419-426 p.Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Springer, 2015
    Series
    Lecture Notes in Computer Science, 9374
    National Category
    Computational Mathematics
    Identifiers
    urn:nbn:se:uu:diva-267963 (URN)10.1007/978-3-319-26520-9_47 (DOI)000373881700047 ()978-3-319-26519-3 (ISBN)
    Conference
    LSSC 2015
    Funder
    Knut and Alice Wallenberg Foundation
    Available from: 2015-11-29 Created: 2015-11-30 Last updated: 2017-10-18Bibliographically approved
    4. Multidimensional performance and scalability analysis for diverse applications based on system monitoring data
    Open this publication in new window or tab >>Multidimensional performance and scalability analysis for diverse applications based on system monitoring data
    Show others...
    2017 (English)In: Parallel Processing and Applied Mathematics, Springer, 2017Conference paper, Published paper (Refereed)
    Place, publisher, year, edition, pages
    Springer, 2017
    Series
    Lecture Notes in Computer Science
    National Category
    Computer Science Computational Mathematics
    Identifiers
    urn:nbn:se:uu:diva-331839 (URN)
    Conference
    PPAM 2017
    Projects
    eSSENCE
    Note

    to appear

    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-20Bibliographically approved
    5. Function-based block multigrid strategy for a two-dimensional linear elasticity-type problem
    Open this publication in new window or tab >>Function-based block multigrid strategy for a two-dimensional linear elasticity-type problem
    Show others...
    2017 (English)In: Computers and Mathematics with Applications, ISSN 0898-1221, E-ISSN 1873-7668, Vol. 74, 1015-1028 p.Article in journal (Refereed) Published
    National Category
    Computational Mathematics
    Identifiers
    urn:nbn:se:uu:diva-323893 (URN)10.1016/j.camwa.2017.05.024 (DOI)
    Funder
    Knut and Alice Wallenberg Foundation
    Available from: 2017-06-03 Created: 2017-06-10 Last updated: 2017-10-18Bibliographically approved
    6. Function-based algebraic multigrid method for the 3D Poisson problem on structured meshes
    Open this publication in new window or tab >>Function-based algebraic multigrid method for the 3D Poisson problem on structured meshes
    2017 (English)Report (Other academic)
    Series
    Technical report / Department of Information Technology, Uppsala University, ISSN 1404-3203 ; 2017-022
    National Category
    Computational Mathematics
    Identifiers
    urn:nbn:se:uu:diva-331778 (URN)
    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-19Bibliographically approved
  • Holm, Jonas
    et al.
    Orebro Univ, Sch Med Sci, Orebro, Sweden..
    Brus, Ole
    Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden..
    Båve, Ullvi
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Landen, Mikael
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Gothenburg Univ, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden..
    Lundberg, Johan
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden..
    Nordanskog, Pia
    Linkoping Univ, Dept Clin & Expt Med, Ctr Social & Affect Neurosci, Fac Hlth Sci, Linkoping, Sweden.;Reg Ostergotland, Dept Psychiat, Linkoping, Sweden..
    von Knorring, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Nordenskjöld, Axel
    Orebro Univ, Sch Med Sci, Orebro, Sweden..
    Improvement of cycloid psychosis following electroconvulsive therapy2017In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 71, no 6, 405-410 p.Article in journal (Refereed)
    Abstract [en]

    Background: The treatment of choice for cycloid psychosis has traditionally been electroconvulsive therapy (ECT), but there is a lack of studies on its effectiveness.

    Aims: The primary aim of this register study was to determine the rates of remission and response after ECT for cycloid psychosis. The secondary aim was to examine possible predictors of outcome.

    Methods: Data were obtained from the National Quality Register for ECT in Sweden. The study population was patients (n=42) who received ECT for acute polymorphic psychotic disorder without symptoms of schizophrenia or for cycloid psychosis between 2011-2015 in 13 hospitals. Remission and response rates were calculated using Clinical Global Impression-Severity (CGI-S) and -Improvement scores, respectively. Variables with possible predictive value were tested using Chi-square and Fisher's exact test.

    Results: The response rate was 90.5%. The remission rate was 45.2%. Of 42 patients, 40 improved their CGI-S score after ECT (p<0.001). The mean number of ECT treatments was 2.5 for non-responders and 7.0 for responders (p=0.010). The mean number of ECT treatments did not differ significantly between remitters and non-remitters (7.2 vs 6.1, p=0.31). None of the other investigated potential predictors was statistically significantly associated with outcome.

    Conclusions: ECT is an effective treatment for cycloid psychosis. Future studies need to compare the outcome of ECT to that of other treatment strategies. Clinical implications: The high response rate with ECT indicates that cycloid psychosis is a clinically useful diagnosis.

  • Hedén, Victoria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Efverström, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Hur blir det nu? Personers upplevelser av att diagnostiseras med typ 2-diabetes: En intervjustudie2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Type 2 diabetes is a growing public health problem. Despite this, there are few studies exploring how people react to this diagnosis, how they deal with the necessary lifestyle changes and what they think about the support offered by the diabetes nurse.

    Aim: To describe individuals’ perceptions and experiences of being diagnosed with type 2 diabetes as well as their impressions of the support offered by the diabetes nurse at the primary health center during the initial period after the diagnosis.

    Methods: Qualitative interview study with semi structured questions. Nine participants were selected through convenience sampling. The interviews were analysed through both manifest and latent content analysis in accordance with the Graneheim and Lundman method.

    Results: The analysis of the interviews resulted in two themes and seven subthemes. The first theme concerns Perceptions and emotions during the initial period of a diabetes diagnosis with the following subthemes: Perceptions at the time of diagnosis, Views and emotions regarding life with diabetes and Handling of everyday life. The second theme concerns Views on and experiences of diabetes care with the following subthemes: Views on the support received from the diabetes nurse, Multi-professional team, Areas of improvement and Health literacy.

    Conclusion: The announcement of a type 2 diabetes diagnosis sometimes came as a chock and sometimes as a relief. Despite being aware of the necessary lifestyle changes, the interviewees had difficulties applying sustainable strategies and solutions in their daily lives. Support from the diabetes nurse was important and could influence the participants’ commitment to introducing healthy habits into their lives. 

  • Falk, Adrian
    Super Duplex Stainless Steel Surfaces and their Effects on Marine Biofouling2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Some of the world’s most ancient, but still viable, organisms have since the beginning of maritime caused problems for the industry. The problems affect both the longlivety and efficiency of ships which is caused by the mere presence of organisms attached to the ship hulls. The organisms, called biofoulers, causes problems with longlivety related to moisture and crevice corrosion which break down the hull material. The problem regarding efficiency of the ship is related to the added hydrodynamical resistance that the biofoulers cause. To limit fouling in the marine industry, paint poisonous to the biofoulers is applied to prohibit growth. Until recent the paint seemed to be a long-term solution but severe damage to the sea life has been traced to the use of antifouling paint. This master thesis aims on exploring one putative solution to the problems related to biofouling. In a maritime perspective, advanced stainless steels are modern materials with use limited to fittings and certain high strength parts. However, in 2014 a small ship constructed completely in super duplex stainless steel 2507 was launched. Immediately the longlivety of the ship increased by several times. The approach was that no antifouling paint was necessary, but biofoulers will grow on the now non-poisonous surface. Surprisingly, in some areas of the ship the biofoulers adhered seemed to detach when driving the ship in certain speeds. This lead to the initiative to examine this mechanism further in the form of this master thesis. The master thesis was held at Sandvik Materials TechnologyAB. The main hypothesis was that adhesion of biofoulers will decrease with decreasing surface roughness. Few studies on the subject stainless steel, biofouling and surface roughness have been performed. Even fewer studies on stainless steel with metallic surface coatings and biofoulers have been performed why another hypothesis was driven: There are surface coatings which will affect growth and adhesion of biofoulers. 22 different stainless steel 2507, 3207 and 316L surface setups were produced by either polishing, coating, bending or magnetizing. Plates were analysed before being immersed in natural seawater in Brest, France for 70 days. After 70 days, the plates were taken up and two major tests were performed at site; fouling amount rank analysis and barnacle adhesion strength measurements. SEM and GDOES were used in the post-experment analysis. No sign of corrosion on the plates were found. The data was processed and results were obtained: Maximum corrosion potential, surface roughness, barnacle adhesion strength and biofouling has quite strong or strong correlations. The lowest barnacle mean adhesion strength was measured to 0.02 MPa. In practical, based on experimental formulated formulas, the low adhesion barnacles would detach in a water flow of 11 m/s. 

  • Zhang, Zhiliang
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology. Northwest University, Xi’an.
    Zhang, Zhifei
    Northwest University, Xi’an.
    Holmer, Lars E.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology. Northwest University, Xi’an.
    Chen, Feiyang
    Northwest University, Xi’an.
    Post-metamorphic allometry in the earliest acrotretoid brachiopods from the lower Cambrian (Series 2) of South China, and its implications2017In: Palaeontology, ISSN 0031-0239, E-ISSN 1475-4983Article in journal (Refereed)
    Abstract [en]

    The earliest growth of post-metamorphic (post-larval) shells in two species of Eohadrotreta is described from the Cambrian Shuijingtuo Formation of South China. Two different growth patterns can be observed by quantifying developmental variations in size and shape of successive stages of post-metamorphic shell growth (including the pedicle foramen forming stage, pedicle foramen enclosing stage and intertrough increasing stage) of Eohadrotreta zhenbaensis and Eohadrotreta? zhujiahensis. The pedicle foramen is never enclosed within the metamorphic shell of E. zhenbaensis, while the enclosed pedicle foramen of E.? zhujiahensis is located directly outside the metamorphic shell after the pedicle foramen enclosing stage. A strongly allometric growth pattern of E. zhenbaensis is demonstrated by the early enclosure of the pedicle foramen; an accelerated lengthening of the ventral intertrough is associated with the development of a more complex dorsal median septum during the intertrough increasing stage. By contrast, E.? zhujiahensis demonstrates possible paedomorphic development by delayed enclosure of pedicle foramen and an associated decreased lengthening of ventral intertrough during the intertrough increasing stage. This ontogenetic developmental sequence represents the marginal accretionary formation and growth of the pedicle foramen, which resembles that of linguloid brachiopods. Furthermore, the developmental process of the pedicle foramen of Eohadrotreta seems to recapitulate the likely evolutionary transition from the Botsfordiidae, with open delthyrium, to the Acrotheloidea, with an enclosed foramen. This study provides a unique opportunity to obtain a complete understanding of the ontogenetic development of the earliest acrotretoids, and casts new light on the phylogeny of lingulate brachiopods.

  • Björktomta, Siv-Britt
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Aarum Hansen, Heidi
    Högskolan i Östfold, Fredrikstad.
    Digital Society: the tension between child protection and children’s agency2017In: Navigating Knowledge Landscapes' 1st International Conference on Health and Person-Centered Care in Digital Society Proceedings of the Conference / [ed] Anna Lydia Svalastog och Srećko Gajović, 2017, 11-12 p.Conference paper (Other academic)
    Abstract [sv]

    Socialtjänsten står inför nya utmaningar i den digitala tidsåldern

    Den digitala tidsåldern med en ökande användning av internet och sociala medier medför nya utmaningar för socialt arbete, och i synnerhet för socialtjänstens arbete med barn och ungdomar. Internetvärldens sociala dynamik behöver finnas med när samhället drar upp riktlinjer och socialtjänsten utvecklar arbetssätt kring barns- och ungas psykosociala hälsa.

    I dag har nära häften av svenska nioåringar tillgång till en surfplatta och fem procent av ettåringarna är dagligen ute på internet. Det är de unga som i högre grad lägger ut texter, bilder, och videos som de själva producerat.  Det är också de unga som är mest aktiva på olika sociala nätverk där de interagerar (samspelar) med både vänner, bekanta och främlingar; inom närområdet men också nationellt och även globalt. Aktiviteterna på internet har många positiva sidor (aspekter) och dagens föräldrar är överlag engagerade i sina barns vardag och har en insikt i sin barns internetanvändning. Samtidigt visar forskning att ett stort antal föräldrar har liten eller ingen kunskap om vad deras barn gör ute på nätet och att många föräldrar underskattar de risker barnen utsätts för online/på nätet.

    Gruppen unga som befinner sig i en riskzon på nätet sammanfaller till stor del med de unga som överlag lever i olika utsatta livssituationer, t.ex. med föräldrar som missbrukar, har psykisk ohälsa eller är arbetslösa. Det kan även vara barn som är utsatta över våld och/eller sexuella övergrepp. I socialtjänstlagen poängteras barns delaktighet i alla beslut som rör deras liv. Detta innebär att socialarbetaren behöver samtala med barn, öga mot öga, för att få del av deras synpunkter när besluta ska fattas.

    I dag behärskar många barn och unga internet och sociala medier bättre än vuxenvärlden. I en kommande studie undersöker Aarum Hansen och Björktomta hur socialtjänsten med hjälp av internet och sociala medier kan utveckla nya metoder för att ge stöd åt unga men också utveckla skydd för barn i riskzonen.

  • Zdanowicz, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    The signature of the large 2015-16 winter storms in Svalbard snowpacks2017Conference paper (Other academic)
  • Ljunggren, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre. Department of Aquatic Resources, Swedish University of Agricultural Sciences.
    Prey choice of great cormorants (Phalacrocorax carbo) in a marine protected area: potential impact on collapsed fish stocks and implications for future monitoring2017Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Great cormorant (Phalacrocorax carbo) populations have experienced a rapid growth in Europe since the 1980s, resulting in conflicts with fisheries over local fish resources. The 8-fjords area is a marine protected area on the Swedish west coast, where long term overfishing has led to a collapse of several local demersal fish stocks. Subsequently, fishing regulations have been implemented to protect and re-establish the stocks of cod- and flatfish species, at the same time as cormorants have increased largely in numbers. The increased predation pressure has raised concerns about the recovery of local fish stocks, although knowledge about cormorant feeding habits are lacking. Here, cormorant prey choice in two subareas of the 8-fjords area is investigated, using morphological identification of prey remains in regurgitated pellets. An estimated 15 077 fishes were identified from a total of 480 pellets. The most important prey families based on relative abundance were flatfish (Pleuronectidae 48%), gobies (Gobiidae 21%) and codfish (Gadidae 13%). Pairwise ANOSIM analyses showed extremely small differences in diet composition between sites (p≤0.003, R<0.08). In comparison to available monitoring fishery data, the diet did not correspond to prey abundance. Estimated fish sizes of a subsample of flat- and codfish showed that juveniles seemed to be preferred. Pellet analysis provided limited information about consumed species and should be combined with other methods for more detailed assessments of cormorant prey choice in the 8-fjords area.

  • Edvinsson, Marie
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Tallkvist, Jonas
    Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, Uppsala, Sweden..
    Nyström-Rosander, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases. Natl Food Agcy, Risk Benefit Assessment Dept, Uppsala, Sweden..
    Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice2017In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, 3642301Article in journal (Refereed)
    Abstract [en]

    Chlamydia pneumoniae (C. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. For its growth C. pneumoniae depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. C. pneumoniae-infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40. Mice had bacteria in the lungs and liver on all days. Inflammatory markers, chemokine Cxcl2 and interferon-gamma, were not affected in the liver on day 40. The copper (Cu)/zinc (Zn) ratio in serum, another marker of infection/inflammation, increased on day 4 and tended to increase again on day 40. The Fe markers, transferrin receptor (TfR), Hepcidin (Hamp1), and ferroportin 1 (Fpn1), increased in the liver on day 4 and then normalized except for TfR that tended to decrease. TfR responses were similar to Fe in serum that increased on day 4 but tended to decrease thereafter. In the liver, Fe was increased on day 4 and also on day 40. The reappearing increases in Cu/Zn on day 40 concomitant with the increase in liver Fe on day 40, even though TfR tended to decrease, and the fact that viable C. pneumoniae was present in the lungs and liver may indicate the early phase of activation of recurrent infection.

  • Boeije, M. F. J.
    et al.
    Delft Univ Technol, Fundamental Aspects Mat & Energy, Fac Sci Appl, Mekelweg 15, NL-2629 JB Delft, Netherlands..
    Delczeg-Czirjak, Erna Krisztina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    van Dijk, N. H.
    Delft Univ Technol, Fundamental Aspects Mat & Energy, Fac Sci Appl, Mekelweg 15, NL-2629 JB Delft, Netherlands..
    Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Bruck, E.
    Delft Univ Technol, Fundamental Aspects Mat & Energy, Fac Sci Appl, Mekelweg 15, NL-2629 JB Delft, Netherlands..
    On the phase stability of CaCu5-type compounds2017In: Journal of Alloys and Compounds, ISSN 0925-8388, E-ISSN 1873-4669, Vol. 722, 549-554 p.Article in journal (Refereed)
    Abstract [en]

    We present a hybrid method to inspect the phase stability of compounds having a CaCu5-type crystal structure. This is done using 2D stability plots using the Miedema parameters that are based on the work function and electron density of the constituent elements. Stable compounds are separated from unstable binary compounds, with a probability of 94%. For stable compounds, a linear relation is found, showing a constant ratio of charge transfer and electron density mismatch. DFT calculations show the same trend. Elements from the s, d, f-block are all reliably represented, elements from the p-block are still challenging.

  • Wikborg, Jonas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Skelettgravarna på Bastubacken: Skelettgravskicket i Mälardalen under romersk järnålder.1996In: TOR, ISSN 0495-8772, Vol. 28, 105-152 p.Article in journal (Other academic)
  • Erixson, Oscar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies. Res Inst Ind Econ IFN, S-10401 Stockholm, Sweden..
    Health responses to a wealth shock: evidence from a Swedish tax reform2017In: Journal of Population Economics, ISSN 0933-1433, E-ISSN 1432-1475, Vol. 30, no 4, 1281-1336 p.Article in journal (Refereed)
    Abstract [en]

    This paper makes two contributions to the literature on the effects of wealth on health. First, it deals with reverse causality and omitted variable bias by exploiting exogenous variation in inherited wealth generated by the repeal of the Swedish inheritance tax. Second, it analyzes responses in health outcomes through the use of administrative registers. The results show that increased wealth has limited short to medium run impacts on objective adult health. This is in line with what has previously been reported in the literature.

  • Isendahl, Christian
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, African and Comparative Archaeology.
    The Archaeology of the Lowland Maya and in Eastern Africa: A Discussion of Some Selected Common Issues.1996In: TOR, ISSN 0495-8772, Vol. 28, 91-104 p.Article in journal (Other academic)
  • Dahl, Caroline
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Källspårning och åtgärdsförslag för rening av dagvatten från Lunda industriområde i Stockholm2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    When more and more people move to the city and the cities expand, so does the amount of impermeable surfaces. This leads to reduced surfaces where rain is allowed to infiltrate the ground. This in turn leads to an increased amount of surface runoff and large amounts of storm water within our cities. On its way through the city the storm water adsorbs pollutants that have been deposited on the surface by traffic and from the air and transports them to nearby waterways and lakes. Since storm water is often released to the recipient without treatment it can have a significant effect on the water quality.

    Bällstaån is one waterway that receives large amounts of storm water from urbanized areas which has resulted in it being one of the most polluted waterways in Stockholm. Mainly high concentrations of nutrients, such as phosphorus, nitrogen, and metals have been recorded during the most recent sampling in 2016. High concentrations of PAH and PFOS have also been detected and to improve the chemical and ecological status of the waterway possible sources of these contaminants are being investigated within the area.

    One possible source that has been identified is storm water from Lunda industrial area located within the runoff area of Bällstaån. Lunda industrial area is about 76 ha and is mainly composed of a mix of industry buildings and offices. To determine potential sources of contaminants within the area an inventory of the site was conducted as well as a storm water simulation in the model SEWSYS with site specific data within this project. The results show that traffic is the largest contributor to pollutants in the storm water from the area but also that zinc corrosion, mainly from fences, is the largest source of zinc. The results from SEWSYS also show that storm water from roofs had lower concentrations of metals and PAH than storm water from roads and other hard surfaces on the ground.

    To improve the quality of the storm water from the area and reduce concentrations of pollutants several different methods were investigated. Since the area is an urban area with limited amount of open areas for large-scale treatment of storm water mainly small-scale methods have been investigated. Since the soil matrix is mainly composed of hard rock and clay the infiltration capacity of the area is considered poor and therefore solutions only based on infiltration have been deemed unsuitable. The main focus of the project has been on investigating how well the methods can treat the water but their ability to delay and store water have also been briefly estimated.

    The solutions considered to be most suitable for the area are ditches or trenches in connection to roads since most of the contaminants originate from these areas and these methods have a high reduction capacity for most contaminants. Biofilters or permeable surfaces could also be used as a complement to increase the amount of storm water that can be treated and stored and to reduce the amount of impermeable surfaces within the area and thereby reduce the amount of storm water in the first place. For roof runoff both biofilters and underground storage performed well enough to reduce concentrations of all pollutants except nitrogen below the guidelines.

  • Kristensson, Anna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Olsson, Carina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Ecofacts Indicating Late Neolithic and Early Bronze Age Farming in Sweden1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 53-68 p.Article in journal (Other academic)
  • Lindgren, Christina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Kvarts som källmaterial: exempel från den mesolitiska boplatsen Hagtorp1996In: TOR, ISSN 0495-8772, Vol. 28, 29-52 p.Article in journal (Other academic)
  • Topsholm, Max
    CHARM Transformation: A case study on change and release management Catella Bank2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of the thesis is to conduct a case study for investigating change and release management at Catella Bank, within the context of IT Service Management (ITSM), by measuring and to provide suggestions for improvements. Incident and operations management is included to enhance the understanding of the historical performance at Catella. The case study is set out to answer the following research questions:

    1. “How does a transition in change management structure impact the performance of successfully delivering both changes and releases of IT services at a financial institution?”

    2. “What are the causes of delays in the delivering changes and releases?”

    3. “How does stakeholder involvement alter the performance of implementing a successful change and release?”

    4. “How do Information Technology, and the corresponding departments manage and control necessary changes and releases of software at present?”

    Research methodology utilized in the thesis includes both qualitative and quantitative research, including interviews, participation in meetings and empirical investigation of internal material at Catella.

    The result from the research has provided a significant collection of issues, as well as suggested solutions for Catella to take to improve organizational maturity in enhancing the capabilities in performing work related to the four managerial disciplines within ITSM. The research culminated in the creation of the CHARM (CHange And Release Management) model, which consists of integrating change and release management into project management, split between three different components for the three organizational levels. The author has created the following components: Strategy matrix, a governance model, and a process model.

  • Boström, Adrian
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Ciuculete, Diana-Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Attwood, Misty M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Krattinger, Regina
    Univ Zurich, Univ Zurich Hosp, Dept Clin Pharmacol & Toxicol, Zurich, Switzerland..
    Nikontovic, Lamia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Titova, Olga E
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Kullak-Ublick, Gerd A.
    Univ Zurich, Univ Zurich Hosp, Dept Clin Pharmacol & Toxicol, Zurich, Switzerland..
    Mwinyi, Jessica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Schiöth, Helgi B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    A MIR4646 associated methylation locus is hypomethylated in adolescent depression2017In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 220, 117-128 p.Article in journal (Refereed)
    Abstract [en]

    Background: Studies of epigenetics and transcriptional activity in adolescents may provide knowledge about possible preventive strategies of depression. Methods: We present a methylome-wide association study (MWAS) and cohort validation analysis of depression in adolescents, in two separate cohorts: discovery (n = 93) and validation data set 1 (n = 78). The genome-wide methylation pattern was measured from whole blood using the Illumina 450K array. A second validation cohort, validation data set 2, consists of post-mortem brain biopsies from depressed adults (n = 58). We performed a MWAS by robust multiple linear regressions of methylation to a modified risk-score assessment of depression. Methylation levels of candidate CpG sites were correlated with expression levels of the associated gene in an independent cohort of 11 healthy volunteers. Results: The methylation state of two CpG sites reliably predicted ratings of depression in adolescents (cg13227623 and cg04102384) (p < 10E-06). Cohort validation analysis confirmed cg04102384 - located in the promoter region of microRNA 4646 (MIR4646) - to be hypomethylated in both validation data set 1 and validation data set 2 (p < 0.05). Cg04102384 was inversely correlated to expression levels of MIR4646-3p in healthy controls (p < 0.05). Limitations: MIR4646 was not differentially expressed in a subset of samples with adolescent depression measured by qRT-PCR measurements. Conclusion: We identify a specific MIR4646 associated epigenetic risk site to be associated with depression in adolescents. Cg04102384 putatively regulates gene expression of MIR4646-3p. Target gene prediction and gene set overrepresentation analysis revealed involvement of this miRNA in fatty acid elongation, a process related to omega-3 fatty acids, previously associated with depression.

  • Chao, Cai
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Shirazi Nasab, Fatemeh
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Linked Data Search and Browse Application2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In order to achieve the ISO 26262 standard on the perspective of requirementstraceability, a huge volume of data has been converted into RDF format, and been stored in a Triple store. The need to have a web application to search and browse that RDF data has been raised. In order to build this application, several open source components such as Apache Solr, Apache Jena, Fuseki and Technologiessuch as Java, HTML, CSS, and Javascript have been used. The application has been evaluated with SUS method, an industry standard and reliable tool formeasuring the system usability, by six engineers from Scania, the evaluation resultin general is positive, five out of six participants successfully retrieved their desiredsearch results.

  • Haxsen, Sören
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    SUITABILITY OF THE EMD-CONWX EUROPE MESOSCALE DATA FOR WIND RESOURCE ASSESSMENTS2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The compilation of wind resource assessments and the implicit long-term correction ofwind measurements require comprehensive data sets. Commonly employed data sets forthis purpose are wind measurements from weather stations as well as SupervisoryControl and Data Acquisition (SCADA) data from existing wind farms. In addition,reanalysis data are a consistent data source. Reanalysis data are a combination ofmeteorological models with measurements of climatology parameters. To increase theperformance of reanalysis data the corresponding data sets are processed with mesoscalemodels. The present study determines the suitability of the readily accessible EMDConWxEurope Mesoscale Data (EMD-ConWx Data) for wind resource assessments.EMD-ConWx Data include hourly wind velocities at seven heights in the range of 10 mup to 200 m and have a spatial resolution of 3 x 3 km. EMD-ConWx Data are based onthe primary reanalysis data set ERA-Interim. The EMD-ConWx Data are compared toSonic Detecting and Ranging (Sodar) measurements at 22 sites in Germany regardingthe parameters wind speed, wind direction and wind speed frequency distribution. Inaddition, the statistical correlation (R) and linear regression (R²) are determined.It was found, that EMD-ConWx Data reveal a moderate accuracy for wind resourceassessments. The determined average wind speed bias of 1.02 m/s, the average rootmeans square error (RMSE) of 1.91 m/s, the average wind direction bias of -0.89° andthe monthly correlation indicate overall an adequate match with the Sodarmeasurements. However, these results entail considerable uncertainties and variances.To reduce these variances and the wind speed overestimation a height shift of 50 m forthe EMD-ConWx wind velocity heights is introduced. The comparison of the EMDConWxwind data at 50 m to Sodar measurements at 100 m leads to a significantreduction of the wind speed bias, but it improves neither the wind direction accuracy northe wind speed correlation. Overall, the EMD-ConWx Data are suitable for windresource assessments and the implicit long-term correction of wind data. The EMDConWxData with the height shift imply the advantage of a proper representation of thewind profile in relation to common reanalysis data, even at sites with complex terrain.

  • Hallgren, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Sociala territorier och exogamirelationer i senmesolitisk tid: En diskussion utifrån boplatsen Pärlängsberget, Södermanland1996In: TOR, ISSN 0495-8772, Vol. 28, 5-28 p.Article in journal (Other academic)
  • Holmberg, Kristin
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Establishing a sustainable water supply in Chonyonyo, Karagwe, Tanzania2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The small village Chonyonyo, in the district Karagwe in the northwest of Tanzania has a shortage of safe drinking water. Women and children spend several hours a day fetching water and gathering firewood to boil the water to make it more suitable for drinking. The need of new sustainable water supply solutions is fundamental for providing more people with safe drinking water.  

    Two water distribution alternatives was suggested by Engineers Without Borders and MAVUNO as possible solutions to supply the community with water.  Alternative 1 consisted of a 10 km distribution system from an already existing groundwater well at the MAVUNO office to Chonyonyo. Alternative 2 consisted of a 3.5 km distribution system from the most neighboring valley to Chonyonyo, where no groundwater well exists today. Both alternatives would be powered by solar panels and operated six hours a day. The most sustainable distribution solution was chosen by modeling the distribution alternatives in the modeling software EPANET. Input parameters to simulate the model were position, elevation and dimension of storage tanks and pipes. Other required input parameters were absolute roughness, water withdrawal, operation hours, description of the withdrawal pattern for the water outlet and other modelling conditions such as a suitable simulation time. The selection of water distribution system was based on minimum requirements of energy used for operation weighed with lowest possible water residence time in the storage tank.

    Water quality analyses of the raw water source for distribution alternative 1 were performed in order to classify the water and select suitable water treatment solutions. The analyses consisted of microbiological and metal/metalloid analyses, and measurements of EC and pH.

    The result of the simulation showed that neither of the distribution alternatives met all the pipe design criteria. The main reason is that the system can not be constantly operated. If this criterion is excluded the optimal solution is distribution alternative 1 with an outer pipe diameter of 110 mm throughout the whole distribution system and a water residence time in the storage tank of 57.1 hours.

    The water quality analysis showed that the ground water source for distribution alternative 1 was affected by surface water and is thus classified as unusable because of high levels of harmful bacteria and lead. The most suitable water treatment solution due to the aspects of sustainable water supply are the microbiological barriers ultrafiltration and UV-light in combination with a treatment method to remove lead from the water. 

  • Gräslund, Bo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Relativ datering.: Om kronologisk metod i nordisk arkeologi1974In: TOR, ISSN 91-7222-057-0, Vol. 16, 7-248 p.Article in journal (Other academic)
  • Public defence: 2017-12-01 13:00 Häggsalen, Ångström, Uppsala
    Nordh, Tim
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    A Quest for the Unseen: Surface Layer Formation on Li4Ti5O12 Li-Ion Battery Anodes2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The electric vehicle itself today outlives its battery, necessitating battery replacement. Lithium titanium oxide (LTO) has, in this context, been suggested as a new anode material in heavy electric vehicle applications due to intrinsic properties regarding safety, lifetime and availability.

    The work presented here is focused on the LTO electrode/electrolyte interface. Photoelectron spectroscopy (PES) has been applied to determine how and if the usage of LTO could prevent extensive anode-side electrolyte decomposition and build-up of a surface layer. The presence of a solid electrolyte interphase (SEI) comprising LiF, carbonates and ether compounds was found in half-cells utilizing a standard ethylene:diethylcarbonate electrolyte with 1 M LiPF6. Via testing of symmetrical LTO-LTO cells, the stability of the formed SEI was put in to question. Moreover, the traditional polyvinylidene difluoride (PVdF) binder was replaced by more environmentally benign carboxylmethyl cellulose (CMC) and polyacrilic acid (PAA) binders in LTO electrodes, and it was found that CMC helped to form a more stable surface-layer that proved beneficial for long term cycling.

    Following the half-cell studies, full-cells were investigated to observe how different cathodes influence the SEI of LTO. The SEI in full-cells displayed characteristics similar to the half-cells, however, when utilizing a high voltage LiNi0.5Mn1.5O4 cathode, more electrolyte decomposition could be observed. Increasing the operational temperature of this battery cell generated even more degradation products on the LTO electrodes. Mn was also found on the anode when using Mn-based cathodes, however, it was found in its ionic state and did not significantly affect the composition or behavior of the observed SEI layer. Furthermore, by exchanging the electrolyte solvent for propylene carbonate, the thickness of the SEI increased, and by replacing the LiPF6 salt for LiBF4 the stability of the SEI improved. Thus is it demonstrated that such a passivation can be beneficial for the long-term surface stability of the electrode. These findings can therefore help prolong the lifetime of LTO-based battery chemistries.

    List of papers
    1. Depth profiling the solid electrolyte interphase on lithium titanate (Li4Ti5O12) using synchrotron-based photoelectron spectroscopy
    Open this publication in new window or tab >>Depth profiling the solid electrolyte interphase on lithium titanate (Li4Ti5O12) using synchrotron-based photoelectron spectroscopy
    2015 (English)In: Journal of Power Sources, ISSN 0378-7753, E-ISSN 1873-2755, Journal of Power Sources, Vol. 294, 173-179 p.Article in journal (Refereed) Published
    Abstract [en]

    The presence of a surface layer on lithium titanate (Li4Ti5O12, LTO) anodes, which has been a topic of debate in scientific literature, is here investigated with tunable high surface sensitive synchrotron-basedphotoelectron spectroscopy (PES) to obtain a reliable depth profile of the interphase. LijjLTO cells with electrolytes consisting of 1 M lithium hexafluorophosphate dissolved in ethylene carbonate:diethyl carbonate (LiPF6 in EC:DEC) were cycled in two different voltage windows of 1.0e2.0 V and 1.4e2.0 V. LTO electrodes were characterized after 5 and 100 cycles. Also the pristine electrode as such, and an electrode soaked in the electrolyte were analyzed by varying the photon energies enabling depth profiling of the outermost surface layer. The main components of the surface layer were found to be ethers, PeO containing compounds, and lithium fluoride.

    Keyword
    Li-ion batteries, LTO, PES, XPS, Surface layer, SEI
    National Category
    Materials Chemistry
    Research subject
    Chemistry with specialization in Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-331106 (URN)10.1016/j.jpowsour.2015.06.038 (DOI)
    Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2017-10-13
    2. Different Shades of Li4Ti5O12 Composites: The Impact of the Binder on Interface Layer Formation
    Open this publication in new window or tab >>Different Shades of Li4Ti5O12 Composites: The Impact of the Binder on Interface Layer Formation
    Show others...
    2017 (English)In: ChemElectroChem, 10.1002/celc.201700395- p.Article in journal (Refereed) Published
    Abstract [en]

    Replacing the traditional PVdF(-HFP) electrode binder by water-soluble alternatives can potentially render electrode fabrication more environmentally benign. Herein, the surface layer formation of stored and cycled samples of two water-based Li4Ti5O12 composites employing either poly(sodium acrylate) (PAA-Na) or sodium carboxymethyl cellulose (CMC-Na) as binders are studied by X-ray photoelectron spectroscopy. In all three formulations, the surface layer composition formed upon storage differed notably from the solid-electrolyte interphase (SEI) layer formed on cycled samples. The surface layer under open-circuit conditions seems to originate mostly from the electrolyte salt (LiPF6) degradation. The comparison with cycled samples after 10 and 100 cycles shows a continuous build-up of an SEI layer on PAA-Na and PVdF-HFP electrodes. In contrast, on CMC-Na containing electrodes the SEI composition remains nearly unchanged. The results correlate well with the electrochemical behavior.

    Keyword
    Li-ion batteries, LTO, binder, interface layer, photoelectron spectroscopy
    National Category
    Materials Chemistry
    Research subject
    Chemistry with specialization in Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-331107 (URN)10.1002/celc.201700395 (DOI)
    Funder
    Swedish Energy AgencyStandUp
    Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2017-10-13
    3. Manganese in the SEI layer of Li4Ti5O12 studied using combined NEXAFS and HAXPES techniques
    Open this publication in new window or tab >>Manganese in the SEI layer of Li4Ti5O12 studied using combined NEXAFS and HAXPES techniques
    Show others...
    2016 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 120, no 6, 3206-3213 p.Article in journal (Refereed) Published
    Abstract [en]

    A combination of hard X-ray photoelectron spectroscopy (HAXPES) and near edge X-ray absorption fine structure (NEXAFS) are here used to investigate the presence and chemical state of crossover manganese deposited on Li-ion battery anodes. The synchrotron based experimental techniques-using HAXPES and NEXAFS analysis on the same sample in one analysis chamber-enabled us to acquire complementary sets of information. The Mn crossover and its influence on the anode interfacial chemistry has been a topic of controversy in the literature. Cells comprising lithium manganese oxide (LiMn2O4, LMO) cathodes and lithium titanate (Li4Ti5O12, LTO) anodes were investigated using LP40 (1 M LiPF6, EC:DEC 1:1) electrolyte. LTO electrodes at lithiated, delithiated, and open circuit voltage (OCV-stored) states were analyzed to investigate the potential dependency of the manganese oxidation state. It was primarily found that a solid surface layer was formed on the LTO electrode and that this layer contains deposited Mn from the cathode. The results revealed that manganese is present in the ionic state, independent of the lithiation of the LTO electrode. The chemical environment of the deposited manganese could not be assigned to simple compounds such as fluorides or oxides, indicating that the state of manganese is in a more complex form.

    National Category
    Other Chemical Engineering
    Research subject
    Chemistry with specialization in Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-267788 (URN)10.1021/acs.jpcc.5b11756 (DOI)000370678700012 ()
    Funder
    Swedish Energy Agency
    Available from: 2015-11-26 Created: 2015-11-26 Last updated: 2017-10-13Bibliographically approved
    4. Understanding the capacity loss in LNMO-LTO lithium-ion cells at ambient and elevated temperatures
    Open this publication in new window or tab >>Understanding the capacity loss in LNMO-LTO lithium-ion cells at ambient and elevated temperatures
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Keyword
    High voltage spinel, cross-talk, electrode interactions, LNMO-LTO, Mn dissolution
    National Category
    Materials Chemistry
    Research subject
    Chemistry with specialization in Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-331117 (URN)
    Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2017-10-13
    5. Surface Layer Formation on Li4Ti5O12 Electrodes in Li-ion Cells with Propylene Carbonate-Based Electrolyte
    Open this publication in new window or tab >>Surface Layer Formation on Li4Ti5O12 Electrodes in Li-ion Cells with Propylene Carbonate-Based Electrolyte
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The increasing usage of lithium titanate (Li4Ti5O12; LTO) as anode material in Li-ion batteries creates challenges and possibilities for the electrolytes. Traditional Li-ion battery electrolytes are tailored primarily for chemistries that use graphite as anode, and are therefore not optimized for LTO electrodes. In this study, propylene carbonate is, together with LiPF6 salt, investigated as an alternative electrolyte system in such batteries. The LTO surface is investigated with photoelectron spectroscopy after the formation cycle and after 10 cycles to characterize the decomposition products. The results show the presence of a surface layer formed on the LTO electrode irrespective of counter electrode used, but with varying thickness. Contrary to conventional ethylene carbonate based electrolytes, no manganese crossover could be observed when using either lithium manganese oxide or lithium nickel manganese oxide/lithium cobalt oxide composite as cathodes in LTO cells.

    Keyword
    Li-ion battery, LTO anode, Interface layer, Propylene carbonate, Photoelectron spectroscopy
    National Category
    Materials Chemistry
    Research subject
    Chemistry with specialization in Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-331116 (URN)
    Available from: 2017-10-10 Created: 2017-10-10 Last updated: 2017-10-13
  • Wikén, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Optimering av blåsmaskinstyrning på Bromma reningsverk2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The aeration step is the most energy consuming process in the wastewater treatment plant, i.e. making the energy usage in this step more efficient is of great concern both in Sweden and world wide. There are some examples of previous studies investigating ways to make the ae- ration control more efficient, though most of these have focused on for example ammonium feedback control rather than blower control which is the main focus of this study.

    Bromma wastewater treatment plant installed three new blowers in december 2016 functioning as suppliers of air to the aeration step in the bioreactor. Since there are still three old blowers operating at the WWTP, there is a need to control two different types of blowers efficiently. This is challenging since the two blower types have different capacities, efficiency and maxi- mum/minimum air flows and a control strategy that optimizes the operation of these two blower types combined needs to take this into account.

    Operational data for the blowers was used to generate a second grade polynome for each blower type which gives the efficiency as a function of produced air flow. These polynomes were further utilized to build a script in MATLAB that chooses the most efficient number of blowers operating and at what air flows for a certain total aeration need. The least square method was used to calibrate a model for calculating energy consumption for the simulated control strate- gy. Calculations for energy consumption from the current control strategy and another strategy proposed by the blower deliverer Sulzer were made in order to decide whether the optimized control strategy was an improvement or not.

    The simulation results and the calculations for energy consumption indicates that the current control strategy at Bromma WWTP is almost as effective as the optimized control strategy. Both strategies sets the new blowers at the first places in the queue. The optimized strategy appears to be more efficient for flows that requires both new and old blowers operating. From the calculations of energy consumption, it was shown that the control strategy from Sulzer de- mands an energy consumption on levels in between the one for the current control strategy and the optimized control strategy.