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  • Lundin, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Malmborg, Agota
    Linkoping Univ, Dept Clin & Expt Med, Obstet & Gynaecol, Linkoping, Sweden.
    Slezak, Julia
    Linkoping Univ, Dept Clin & Expt Med, Clin Chem, Linkoping, Sweden.
    Danielsson, Kristina Gemzell
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Bixo, Marie
    Umea Univ, Dept Clin Sci Obstet & Gynaecol, Umea, Sweden.
    Bengtsdotter, Hanna
    Orebro Univ, Dept Obstet & Gynaecol, Orebro, Sweden.
    Marions, Lena
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
    Lindh, Ingela
    Gothenburg Univ, Sahlgrenska Univ Hosp, Dept Obstet & Gynaecol, Sahlgrenska Acad, Gothenburg, Sweden.
    Theodorsson, Elvar
    Linkoping Univ, Dept Clin & Expt Med, Clin Chem, Linkoping, Sweden.
    Hammar, Mats
    Linkoping Univ, Dept Clin & Expt Med, Obstet & Gynaecol, Linkoping, Sweden.
    Sundström Poromaa, Inger
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Sexual function and combined oral contraceptives: a randomised, placebo-controlled trial2018In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 7, no 11, p. 1208-1216Article in journal (Refereed)
    Abstract [en]

    Objective: The effect of combined oral contraceptives (COCs) on female sexuality has long been a matter of discussion, but placebo-controlled studies are lacking. Thus, the aim of the present study was to investigate if an oestradiol-containing COC influences sexual function.

    Design: Investigator-initiated, randomised, double-blinded, placebo-controlled clinical trial where 202 healthy women were randomised to a combined oral contraceptive (1.5 mg oestradiol and 2.5 mg nomegestrol acetate) or placebo for three treatment cycles.

    Methods: Sexual function at baseline and during the last week of the final treatment cycle was evaluated by the McCoy Female Sexuality Questionnaire. Serum and hair testosterone levels were assessed at the same time points.

    Results: Compared to placebo, COC use was associated with a small decrease in sexual interest (COC median change score: -2.0; interquartile range (IQR): -5.0 to 0.5 vs placebo: -1.0; IQR: -3.0 to 2.0, P=0.019), which remained following adjustment for change in self-rated depressive symptoms (B= -0.80 +/- 0.30, Wald =7.08, P=0.008). However, the proportion of women who reported a clinically relevant deterioration in sexual interest did not differ between COC or placebo users (COC 18 (22.2%) vs placebo 16 (17.8%), P=0.47). Change in other measured aspects of sexual function as well as total score of sexual function did not differ between the two treatments.

    Conclusions: This study suggests that use of oestradiol-based COCs is associated with reduced sexual interest. However, the changes are minute, and probably not of clinical relevance.

  • Agathangelidis, Andreas
    et al.
    Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
    Sutton, Lesley Ann
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Hadzidimitriou, Anastasia
    Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
    Tresoldi, Cristina
    IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect, Milan, Italy.
    Langerak, Anton W.
    Erasmus Univ, Med Ctr, Lab Med Immunol, Dept Immunol, Rotterdam, Netherlands.
    Belessi, Chrysoula
    Nikea Gen Hosp, Hematol Dept, Piraeus, Greece.
    Davi, Frederic
    Hop La Pitie Salpetriere, AP HP, Dept Hematol, Paris, France;UPMC Univ Paris 06, UMRS 1138, Paris, France.
    Rosenquist, Richard
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Stamatopoulos, Kostas
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
    Ghia, Paolo
    IRCCS Ist Scientifico San Raffaele, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy.
    Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation2018In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 141, article id e57787Article in journal (Refereed)
    Abstract [en]

    During B cell maturation, the complex process of immunoglobulin (IG) gene V(D)J recombination coupled with somatic hypermutation (SHM) gives rise to a unique DNA sequence within each individual B cell. Since B cell malignancies result from the clonal expansion of a single cell, IG genes represent a unique molecular signature common to all the malignant cells within an individual patient; thus, IG gene rearrangements can be used as clonal markers. In addition to serving as an important clonal identifier, the IG gene sequence can act as a 'molecular timeline' since it is associated with specific developmental stages and hence reflects the history of the B cell involved in the neoplastic transformation. Moreover, for certain malignancies, in particular chronic lymphocytic leukemia (CLL), the IG gene sequence holds prognostic and potentially predictive capabilities. That said, extrapolating meaningful conclusions from IG gene sequence analysis would be impossible if robust methods and tools were not available to aid in their analysis. This article, drawing on the vast experience of the European Research Initiative on CLL (ERIC), details the technical aspects and essential requirements necessary to ensure reliable and reproducible IG gene sequence analysis in CLL, a test that is now recommended for all CLL patients prior to treatment. More specifically, the various analytical stages are described ranging from the identification of the clonotypic IG gene rearrangement and the determination of the nucleotide sequence to the accurate clinical interpretation of the IG gene sequence data.

  • Wille, Michelle
    et al.
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden;Peter Doherty Inst Infect & Immun, WHO Collaborating Ctr Reference & Res Influenza, 792 Elizabeth St, Melbourne, Vic 3000, Australia.
    Latorre-Margalef, Neus
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden;Lund Univ, Dept Biol, Ecol Bldg, S-22362 Lund, Sweden.
    Tolf, Conny
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden.
    Halpin, Rebecca
    J Craig Venter Inst, Dept Infect Dis, Rockville, MD USA.
    Wentworth, David
    J Craig Venter Inst, Dept Infect Dis, Rockville, MD USA.
    Fouchier, Ron A. M.
    Erasmus MC, Dept Virol, Rotterdam, Netherlands.
    Raghwani, Jayna
    Univ Oxford, Dept Zool, Oxford OX1 3SY, England.
    Pybus, Oliver G.
    Univ Oxford, Dept Zool, Oxford OX1 3SY, England.
    Olsen, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Waldenström, Jonas
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden.
    Where do all the subtypes go?: Temporal dynamics of H8-H12 influenza A viruses in waterfowl2018In: Virus Evolution, ISSN 0042-725X, E-ISSN 2281-1605, Vol. 4, no 2, article id vey025Article in journal (Refereed)
    Abstract [en]

    Influenza A virus (IAV) is ubiquitous in waterfowl. In the northern hemisphere IAV prevalence is highest during the autumn and coincides with a peak in viral subtype diversity. Although haemagglutinin subtypes H1-H12 are associated with waterfowl hosts, subtypes H8-H12 are detected very infrequently. To better understand the role of waterfowl in the maintenance of these rare subtypes, we sequenced H8-H12 viruses isolated from Mallards (Anas platyrhynchos) from 2002 to 2009. These rare viruses exhibited varying ecological and phylodynamic features. The Eurasian clades of H8 and H12 phylogenies were dominated by waterfowl sequences; mostly viruses sequenced in this study. H11, once believed to be a subtype that infected charadriiformes (shorebirds), exhibited patterns more typical of common virus subtypes. Finally, subtypes H9 and H10, which have maintained lineages in poultry, showed markedly different patterns: H10 was associated with all possible NA subtypes and this drove HA lineage diversity within years. Rare viruses belonging to subtypes H8-H12 were highly reassorted, indicating that these rare subtypes are part of the broader IAV pool. Our results suggest that waterfowl play a role in the maintenance of these rare subtypes, but we recommend additional sampling of non-traditional hosts to better understand the reservoirs of these rare viruses.

  • Kaufmann, Wanja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Vulnerabilities in a Wetter World: A study on migration as an adaptation strategy to climate change, with under-five mortality as an intermediating variable.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis strives to examine firstly if migration is a significant adaptation strategy to the experience of abundant precipitation, and secondly whether under-five mortality works attenuating or enhancing when being an intermediating factor. With cross-country panel data for precipitation and migration percentage for 169 countries over the world for the time period 1950-2005, a fixed effect model has been created for both parts of the analysis — in the first one to estimate the effects of abundant precipitation on migration flows, and in the second one to examine if and how the mortality rates of children under the age of five works as driver on the effect between abundant precipitation and migration. The results illustrated a positive and significant effect of precipitation on migration when same-year data was used. For the five-year lag data and the ten-year lag data, the null hypothesis which indicates that there is no relationship between the variables could not be rejected, but there were still results that indicated that the migration goes up in a five-year perspective and decreases in a ten-year perspective. The results from the first part of the analysis do not illustrate enormous effects. For the second part of the analysis, results show that the effect of precipitation on under-five mortality does, in contrary to the stated hypothesis, implicate an attenuation as opposed to an enhancement of the effect of precipitation on migration. Due to low precision and non-significant results, it is not possible to determine how exactly the effects are directly affecting each other. This thesis has however helped to prove that one can reject that the effects are strongly enhancing each other.

  • Persson, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Centre for Gender Research.
    Experiences of Maternal Birth Injuries: How Gender and Sexuality Norms Affect Diagnostics, Everyday Life and Healthcare in Sweden2018Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    This thesis explores women’s experiences of maternal birth injuries, focusing on how gender and sexuality norms affect diagnostics, everyday life and healthcare in Sweden. The empirical material consists of 383 answers to an online questionnaire. The theoretical approaches are centred on how bodies are viewed and valued in a Western society, especially in connection to the social construction of health and illness in relation to gender and reproduction. Existing medical descriptions of maternal birth injuries are explored in comparison to the participants’ own definitions. No clear definition is found and the analysis demonstrates that maternal birth injuries can cause both mental and physical injuries/consequences, arising from both vaginal and caesarean births, and a shift away from mainly focusing on physical damage caused by vaginal delivery is suggested. Everyday life is affected in several ways by the complications that the birth injuries lead to, and many participants suffer severely, both physically and mentally. A majority of the participants seek care for these complications, and their experiences of Swedish healthcare reveal an attitude wherein maternal birth injuries are seen as something normal. Many do not receive sufficient care, if treated at all, and gender and sexuality norms affect how medical personnel act and speak. This demonstrates patriarchal structures, medical hierarchies and heterosexual norms within Swedish healthcare, which devalue female-coded bodies as well as their pain and pleasures. Hence, this thesis addresses the importance of researching the effect of underlying structures on care of women in general, and of maternal birth injuries in particular.

  • Public defence: 2019-03-08 13:15 Svedbergsalen (B8), Uppsala
    Al-Amin, Rasel Abdullah
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Science for Life Laboratory, SciLifeLab, Science for Life Laboratory, SciLifeLab.
    Molecular Approaches to Explore Drug-Target Interactions2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Improved means to assess the clinical potential of drug candidates can critically influence development of new therapeutic entities, a central aim in medical life science. Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. This thesis includes new methodology to investigate target engagement - that is the tendency for these drugs and drug candidates to bind their intended target molecules versus any off-targets. This is a matter of great importance and current strong interest in the pharmaceutical industry as well as academically and an important aim for precision medicine. Paper I describes the target engagement-mediated amplification (TEMA) technique, an accurate, selective and physiological relevant techniques to monitor target binding by DNA-conjugated low molecular weight drug molecules. The DNA conjugated forms of the drugs are uniquely suited to accurately and sensitively reveal the binding characteristics of drugs directly in relevant tissues. Paper II describes the evaluation of cellular thermal shift assays (CETSA) by multiplex proximity extension assays (PEA), to sensitively measure binding of drugs to their proper targets and off-targets in minimal samples of cells and tissues, and for many targets and samples in parallel. The technique provides valuable advantages during drug development, and potentially also in clinical care. Paper III describes a high-throughput approach to use in situ proximity ligation assays to investigate protein interactions or modifications along with phenotypic responses to drugs or cytokines. The technique allows responses by large numbers of cells to be evaluated by automated microscopy and computer-based analysis. Our approach expands the scope for combined molecular and morphological profiling, offering an information-rich means to profile cellular responses to drugs and other agents at the single cell level.

    List of papers
    1. Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ
    Open this publication in new window or tab >>Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    It is important to determine the localization of drugs or drug candidates at cellular and subcellular resolution in relevant clinical specimens. This is necessary to evaluate drug candidates from early stages of drug development to clinical evaluation of mutations potentially causing resistance to targeted therapy. We describe a technology where oligonucleotide-conjugated drug molecules are used to visualize and measure target engagement in situ via rolling-circle amplification (RCA) of circularized oligonucleotide probes (padlock probes). We established this target engagement-mediated amplification (TEMA) technique using kinase inhibitor precursor compounds, and we applied the assay to investigate target interactions by microscopy in pathology tissue sections and using flow cytometry for blood samples from patients, as well as in commercial arrays including almost half of all human proteins.  In the variant proxTEMAtechnique, in situ proximity ligation assays were performed by combining drug-DNA conjugates with antibody-DNA conjugates to specifically reveal drug binding to particular on- or off-targets in pathological tissues sections. In conclusion, the TEMA methods successfully visualize drug-target interaction by experimental and clinically approved kinase inhibitors in situ and with kinases among a large collection of arrayed proteins. 

    National Category
    Natural Sciences
    Research subject
    Molecular Biotechnology
    Identifiers
    urn:nbn:se:uu:diva-374262 (URN)
    Available from: 2019-01-18 Created: 2019-01-18 Last updated: 2019-01-21
    2. Sensitive Measurement of Drug-Target Engagement Using Cellular Thermal Shift Assays with Multiplex Proximity Extension Assay Readout
    Open this publication in new window or tab >>Sensitive Measurement of Drug-Target Engagement Using Cellular Thermal Shift Assays with Multiplex Proximity Extension Assay Readout
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The ability to measure target engagement in cellular contexts is key for successful drug discovery and clinical care. The cellular thermal shift assay (CETSA) provides realistic information about drug binding in cells and tissues, revealing drug-target engagement in clinically relevant samples. CETSA combined with mass spectrometry (MS) readout can be applied in the early hit identification phase to generate target engagement data for large sets of proteins. However, the analysis low-throughput and requires substantial amounts of sample material. Here, we combined CETSA and the multiplex proximity extension assay (PEA) for analysis of target engagement of 184 proteins from minimal sample material treated with kinase inhibitors. PEA allows analyses of large numbers of specific target proteins at high sensitivity in small sample aliquots. We observed concordant results for proteins measured by MS or PEA. This highly sensitive CETSA-PEA procedure is promising for monitoring drug-target engagement in small aliquots of patient material for analysis of drug binding in drug development and in clinical settings. 

    National Category
    Natural Sciences
    Research subject
    Medical Biochemistry
    Identifiers
    urn:nbn:se:uu:diva-374264 (URN)
    Available from: 2019-01-18 Created: 2019-01-18 Last updated: 2019-01-21
    3. High-throughput in situ mapping of phosphorylated protein complexes across the cell cycle and in response to drugs
    Open this publication in new window or tab >>High-throughput in situ mapping of phosphorylated protein complexes across the cell cycle and in response to drugs
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Interactions and posttranslational modifications (PTMs) of proteins orchestrate cellular responses to cytokines, drugs or other agents, but it has been difficult to monitor and characterize these dynamic events at high-throughput. Here, we have established a semi-automated system for large-scale in situ proximity ligation assays (isPLA). The protocol combines isPLA in microtiter wells with automated microscopy and computer-based image analysis whereby specific protein phosphorylations and interactions are digitally recorded in cells, along with measurements of morphological features. We demonstrate how this platform can improve analysis of cellular signaling by investigating TGF-b responsive Smad2 linker phosphorylations and complex formations over time and across millions of individual cells. We depict single cell responses in relation to e.g. local cell crowding and cell cycle progression via measurements of DNA content and nuclear size. Finally, we illustrate the application of the protocol for demonstrating drug effects by screening a library of phosphatase inhibitors. In summary, our approach expands the scope for image-based single cell analyses by combining observations of protein interactions and modifications with morphological details of individual cells at high throughput.

    National Category
    Natural Sciences
    Research subject
    Biochemistry; Molecular Cellbiology; Molecular Biotechnology
    Identifiers
    urn:nbn:se:uu:diva-374248 (URN)
    Available from: 2019-01-18 Created: 2019-01-18 Last updated: 2019-01-21
  • Public defence: 2019-03-08 13:15 Polhemsalen, Uppsala
    Wang, JunXin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Angle dependent light scattering of functional nanoparticle composites2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Varies functional nanoparticles play crucial roles in energy- and optical- related applications. The incorporation of functional nanoparticles into non-absorbing polymers to form optical absorption and scattering thin films have attracted considerable interest due to a successful selection of particles and matrices, synergistic effects of separation and fixation of particles, and controllable layer thicknesses and structures. To investigate the optical parameters, especially absorption and scattering coefficients of the nanocomposites, it is critical to evaluate and optimize those particle based functional layers.

    In this thesis, we mainly focus on developing approaches for the inversion of scattering and absorption coefficients from optically measured transmittance and reflectance spectra. A two-flux radiative transfer model is robust for this purpose, but its limitation lies in failing to converge the transmittance and reflectance spectra to experimental data owing to the approximation of the completely diffuse scattering patterns. We carried out thorough characterization of angle- and wavelength-resolved light scattering on those nanocomposites with metallic Au, ferromagnetic Fe3O4 and photocatalytic TiO2 nanoparticles. We further developed an empirical scattering phase function, which can fully represent the scattering distributions for aggregated particles in the multiple scattering regime, as well as the single scattering in the Rayleigh, Mie and geometric optical scattering regimes. The incorporation of angle-resolved data into the two-flux theory to derive scattering and absorption coefficients have been validated using the functional nanoparticle composites. Several approximations are also proposed to obtain the scattering and absorption coefficients when angle resolved measurements were not available.

    The optical performance was investigated on the nanocomposites mentioned above with varied sizes, shapes and concentrations using a spectrophotometer, an in-plane scatterometer and an out-of-plane goniometer. Single particle dark-field scattering spectra were also obtained for Au, Fe3O4, and TiO2 particles in the forward and backward directions.

    List of papers
    1. General Method for Determining Light Scattering and Absorption of Nanoparticle Composites
    Open this publication in new window or tab >>General Method for Determining Light Scattering and Absorption of Nanoparticle Composites
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    2018 (English)In: Advanced Optical Materials, ISSN 2162-7568, E-ISSN 2195-1071, Vol. 6, article id 1801315Article in journal (Refereed) Published
    Abstract [en]

    Scattering and absorption from nanoparticles are of major importance in optical research as well as in a range of applications. The Kubelka–Munk two-flux radiative transfer model gives a simple description of light scattering in nanoparticle composite materials, but inversion of experimental transmittance and reflectance data to obtain backscattering and absorption coefficients remains challenging. Here, a general method for evaluating these parameters from transmittance and reflectance spectra, combined with spectral angle resolved light scattering measurements is developed. The angular dependence is approximatedby an extension of the empirical Reynolds–McCormick phase function, which is fitted to the experimental angle resolved light scattering data. This approach is verified by measurements on three typical nanoparticle/polymer composites containing plasmonic Au, ferromagnetic Fe3O4, and dielectric TiO2 particles. An approximation to the angular scattering pattern is further demonstrated, which can be applied to obtain the optical parameters using only reflectance and transmittance data, in cases where angle-resolved measurements are not available. These results can be extended to a wide range of isotropic, anisotropic, and multiple scattering systems, and will be highly useful in the fields of light scattering coatings/metamaterials, UV-shielding films, displays, absorption/scattering layers in solar cells and biological scatterers.

    Place, publisher, year, edition, pages
    Wiley-VCH Verlagsgesellschaft, 2018
    National Category
    Other Physics Topics Condensed Matter Physics
    Research subject
    Engineering Science with specialization in Solid State Physics
    Identifiers
    urn:nbn:se:uu:diva-370103 (URN)10.1002/adom.201801315 (DOI)
    Available from: 2018-12-19 Created: 2018-12-19 Last updated: 2019-01-31Bibliographically approved
    2. Enhanced UV protection and water adsorption properties of transparent poly(methyl methacrylate) films through incorporation of amorphous magnesium carbonate nanoparticles
    Open this publication in new window or tab >>Enhanced UV protection and water adsorption properties of transparent poly(methyl methacrylate) films through incorporation of amorphous magnesium carbonate nanoparticles
    (English)Manuscript (preprint) (Other academic)
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-354510 (URN)
    Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2019-01-21
    3. Angle dependent light scattering by gold nanospheres
    Open this publication in new window or tab >>Angle dependent light scattering by gold nanospheres
    2015 (English)In: INERA Conference: Book of Abstracts, 2015, p. 71-, article id 012018Conference paper, Poster (with or without abstract) (Refereed)
    Abstract [en]

    Gold nanocrystals exhibit unique optical properties in enhanced light absorption and scattering owing to their extremely large scattering/absorption cross. sections and large electric field enhancements generated by localized surface plasmon resonance. In this work, the optical properties of gold nanospheres with diameters of 60 nm and 200 nm with remarkable uniformity in size were studied both numerically and experimentally. The total transmittance and reflectance as well as the angle. resolved light scattering intensities of the gold nanospheres were measured. The absorption and scattering coefficients were obtained by fitting the experimental data to the two. flux theory and were in qualitative agreement with single. scattering calculations using the Mie theory.

    Series
    Journal of Physics Conference Series, ISSN 1742-6588 ; 682
    National Category
    Condensed Matter Physics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-266863 (URN)10.1088/1742-6596/682/1/012018 (DOI)000372173400018 ()
    Conference
    Light in Nanoscience and Nanotechnology, LNN 2015, October 20-22, 2015, Hissar, Bulgaria
    Available from: 2015-11-12 Created: 2015-11-12 Last updated: 2019-01-21Bibliographically approved
    4. Light Scattering by 2D- and 3D- Angle-Resolved Spectroscopy
    Open this publication in new window or tab >>Light Scattering by 2D- and 3D- Angle-Resolved Spectroscopy
    2016 (English)In: INERA Conference: Vapor Phase Technologies for Metal Oxide and Carbon Nanostructures, 2016Conference paper, Poster (with or without abstract) (Refereed)
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Solid State Physics
    Identifiers
    urn:nbn:se:uu:diva-307584 (URN)
    Conference
    INERA Conference: Vapor Phase Technologies for Metal Oxide and Carbon Nanostructures, Velingrad, Bulgaria, July 5-9, 2016
    Available from: 2016-11-17 Created: 2016-11-17 Last updated: 2019-01-21Bibliographically approved
  • Wennström, Patrick
    Department of Urban and Rural Development, Swedish University of Agricultural Sciences.
    Perspectives on the pastoral landscape: Combining remote sensing ob- servations and pastoralist per- ceptions in southern Tamil Nadu, India2018In: Asia in Focus: A Nordic journal on Asia by early career researchers, ISSN 2446-0001, no 5, p. 15-27Article in journal (Refereed)
    Abstract [en]

    This article explores how land cover change studies could be advanced through a methodology that integrates remote sensing (RS) observations and perceptions from the ground. This is done through a case study in southern Tamil Nadu, India where changes in the pastoral landscape are investigated from two perspectives: from space through satellite images and from the ground through interviews and participatory mapping. RS results provide valuable insights about large-scale changes in the landscape, which could not have been captured through interviews. Grasslands, an important source of livestock feed, have decreased while agricultural land and built-up land has increased between the years 1992 and 2014. The qualitative data generated a deeper understanding of land cover change dynamics and revealed the complexity of pastoralist livelihoods where shrinking pastures is perceived as one of many challenges. Combining the two data types and analysing the gaps between them indicates that pastoralists are referring to the loss of relatively small but significant grazing lands. Such changes are not within the domain of detectable changes, which indicates that policy intended to improve pastoralist conditions based entirely on RS would most likely fail. This risk could be minimized by integrating qualitative data to the RS analysis.

  • Thörnqvist, Per-Ove
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology. Uppsala Univ, Dept Neurosci, Biomed Ctr BMC, Physiol Unit, Box 593, SE-75124 Uppsala, Sweden.
    McCarrick, Sarah
    Karolinska Inst, Inst Environm Med, Biochem Toxicol Unit, Box 210, SE-17177 Stockholm, Sweden.
    Ericsson, Maja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
    Roman, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Winberg, Svante
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
    Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish2019In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 359, p. 927-934Article in journal (Refereed)
    Abstract [en]

    Individual variation in coping with environmental challenges is a well-known phenomenon across vertebrates, including teleost fish. Dopamine is the major transmitter in the brain reward networks, and important for motivational processes and stress coping. Functions of the endogenous opioid system are not well studied in teleosts. However, in mammals the activity in the brain reward networks is regulated by the endogenous opioid system. This study aimed at investigating if there was a correlation between risk-taking behavior and the expression of dopamine and opioid receptors in the zebrafish (Danio rerio) brain. Risk-taking behavior was assessed in a novel tank diving test, and the most extreme high risk taking, i.e. bold, and low risk taking, i.e. shy, fish were sampled for qPCR analysis of whole brain gene expression. The expression analysis showed a significantly higher expression of the dopamine D2 receptors (drd2a and drd2b) and the delta opioid receptor (DOR; oprd1b) in bold compared to shy fish. Besides reward and reinforcing properties, DORs are also involved in emotional responses. Dopamine D2 receptors are believed to be important for active stress coping in rodents, and taken together the results of the current study suggest similar functions in zebrafish. However, additional experiments are required to clarify how dopamine and opioid receptor activation affect behavior and stress coping in this species.

  • Rångtell, Frida H
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Karamchedu, Swathy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Andersson, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Liethof, Lisanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Bucaro, Marcela Olaya
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Lampola, Lauri
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Schiöth, Helgi B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Cedernaes, Jonathan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Benedict, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner2019In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 28, no 1, article id e12651Article in journal (Refereed)
    Abstract [en]

    Acute sleep deprivation can lead to judgement errors and thereby increases the risk of accidents, possibly due to an impaired working memory. However, whether the adverse effects of acute sleep loss on working memory are modulated by auditory distraction in women and men are not known. Additionally, it is unknown whether sleep loss alters the way in which men and women perceive their working memory performance. Thus, 24 young adults (12 women using oral contraceptives at the time of investigation) participated in two experimental conditions: nocturnal sleep (scheduled between 22:30 and 06:30 hours) versus one night of total sleep loss. Participants were administered a digital working memory test in which eight-digit sequences were learned and retrieved in the morning after each condition. Learning of digital sequences was accompanied by either silence or auditory distraction (equal distribution among trials). After sequence retrieval, each trial ended with a question regarding how certain participants were of the correctness of their response, as a self-estimate of working memory performance. We found that sleep loss impaired objective but not self-estimated working memory performance in women. In contrast, both measures remained unaffected by sleep loss in men. Auditory distraction impaired working memory performance, without modulation by sleep loss or sex. Being unaware of cognitive limitations when sleep-deprived, as seen in our study, could lead to undesirable consequences in, for example, an occupational context. Our findings suggest that sleep-deprived young women are at particular risk for overestimating their working memory performance.

  • Parkash, Vimal
    et al.
    Umea Univ, Dept Med Biochem & Biophys, SE-90187 Umea, Sweden.
    Kulkarni, Yashraj
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry.
    ter Beek, Josy
    Umea Univ, Dept Med Biochem & Biophys, SE-90187 Umea, Sweden.
    Shcherbakova, Polina V.
    Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Fred & Pamela Buffett Canc Ctr, Omaha, NE 68198 USA.
    Kamerlin, Shina C. Lynn
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry.
    Johansson, Erik
    Umea Univ, Dept Med Biochem & Biophys, SE-90187 Umea, Sweden.
    Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 373Article in journal (Refereed)
    Abstract [en]

    The most frequently recurring cancer-associated DNA polymerase epsilon (Pol epsilon) mutation is a P286R substitution in the exonuclease domain. While originally proposed to increase genome instability by disrupting exonucleolytic proofreading, the P286R variant was later found to be significantly more pathogenic than Pol epsilon proofreading deficiency per se. The mechanisms underlying its stronger impact remained unclear. Here we report the crystal structure of the yeast orthologue, Pol epsilon-P301R, complexed with DNA and an incoming dNTP. Structural changes in the protein are confined to the exonuclease domain, with R301 pointing towards the exonuclease site. Molecular dynamics simulations suggest that R301 interferes with DNA binding to the exonuclease site, an outcome not observed with the exonuclease-inactive Pol epsilon-D290A, E292A variant lacking the catalytic residues. These results reveal a distinct mechanism of exonuclease inactivation by the P301R substitution and a likely basis for its dramatically higher mutagenic and tumorigenic effects.

  • Rask-Andersen, Mathias
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Karlsson, Torgny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Ek, Weronica E
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Johansson, Åsa
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 339Article in journal (Refereed)
    Abstract [en]

    Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. 98 independent associations with body fat distribution are identified, 29 that have not previously been associated with anthropometric traits. A high degree of sex-heterogeneity is observed and the effects of 37 associated variants are stronger in females compared to males. Our findings also implicate that body fat distribution in females involves mesenchyme derived tissues and cell types, female endocrine tissues as well as extracellular matrix maintenance and remodeling.

  • He, Minglong
    et al.
    Fic, Krzysztof
    Poznan Univ Tech, Inst Chem & Tech Electrochem, PL-60695 Poznan, Poland.
    Frackowiak, Elzbieta
    Poznan Univ Tech, Inst Chem & Tech Electrochem, PL-60695 Poznan, Poland.
    Novak, Petr
    Paul Scherrer Inst, Electrochem Lab, CH-5232 Villigen, Switzerland.
    Jämstorp, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry. Paul Scherrer Inst, Electrochem Lab, CH-5232 Villigen, Switzerland.
    Towards more Durable Electrochemical Capacitors by Elucidating the Ageing Mechanisms under Different Testing Procedures2019In: CHEMELECTROCHEM, ISSN 2196-0216, Vol. 6, no 2, p. 566-573Article in journal (Refereed)
    Abstract [en]

    Electrical double-layer capacitors (EDLCs) commonly denoted supercapacitors are rechargeable energy storage devices with excellent power and energy delivery metrics intermediate to conventional capacitors and batteries. High-voltage aqueous electrolyte based EDLCs are particularly attractive due to their high-power capability, facile production, and environmental advantages. EDLCs should last for thousands of cycles and evaluation of future cell chemistries require long-term and costly galvanostatic cycling. Voltage holding tests have been proposed to shorten evaluation time by accelerating cell degradation processes. Whether voltage holding can replace cycling completely remains undemonstrated. In this work, a systematic investigation of the influence of testing procedure on cell performance is presented. The state-of-the-art post-mortem and operando experimental techniques are implemented to elucidate ageing mechanisms and kinetics inside EDLC cells under different testing procedures. Carbon corrosion occurring on the positively polarized electrode leads to the lower active surface area and higher oxygen content. On the contrary, an increase of surface area and micropore volume are observed on the negatively polarized electrode. Repeated galvanostatic cycles at U<1.6 V appears to facilitate the depletion of oxygen species on the positively polarized electrode in comparison with voltage holding, which indicates a more complex degradation mechanism during cycling. Caution is advised when comparing results from different test procedures.

  • Tofters, Emelie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    External support in civil wars and its impact on civilians: A comparative study of the Guatemalan and Salvadoran civil wars2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Hedström Andersson, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Westerlund Johansson, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelse av hälso- och sjukvårdens tillgänglighet i svensk glesbygd: En kvalitativ intervjustudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund. Vårdens tillgänglighet i glesbygd skiljer sig från storstäder, både i Sverige och internationellt.

    Syfte. Att undersöka hur patienter i svensk glesbygd upplever tillgängligheten av hälso- och sjukvård.

    Metodbeskrivning. Kvalitativ metod och induktiv ansats med deskriptiv design. Åtta semi-strukturerade telefonintervjuer genomfördes med personer i åldrarna 24-90 år.  Innehållet analyserades med en modifierad version av Graneheim och Lundmans innehållsanalys (2004).

    Resultat. Patienter i Arjeplogs kommun ansåg att hälso- och sjukvårdens tillgänglighet brister på grund av avsaknad av fast anställd läkare på vårdcentralen. Bristen på kontinuitet ledde till att informanterna upplevde att de kände bristande tillit till vården och avstod från att söka vård. Även tillgängligheten till akutsjukvård var bristande eftersom resurser inte alltid fanns tillgängliga och skapade oro hos patienterna ifall de skulle bli akut sjuka. Avstånden och tillgängligheten till sjukvård i Arjeplog gjorde att patienter valde att åka längre sträckor till andra sjukhus där de kunde få den hjälp de behövde även om det innebar besvär. För de äldre innebar de långa ressträckorna att de ibland valde att avstå behandlingar på grund av bristande fysisk ork. Teknologins användning såsom mobiltelefon och videosamtal gav i många fall möjligheter att ersätta fysiska besök.  

    Slutsats. För att utöka tillgängligheten av hälso- och sjukvården i Arjeplog skulle användning av videosamtal kunna utvecklas, då det kan ersätta fysiska besök på avlägsna sjukhus i många fall. Informanterna önskade att det skulle finnas fast anställda läkare på vårdcentralen som kände till förutsättningarna i kommunen. Sjuksköterskor skulle kunna ta över vissa läkaruppgifter för att minska konsekvenserna av läkarbristen i kommunen.

  • Bolander, Elin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Ahlund, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Föräldrar och förskolepersonals skattningar av psykisk hälsa hos treåringar2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Mental health problems are increasing among children and youth. Previous research emphasises the importance of early detection. Signs of mental health and behavior problems can be detected through parents’ and preschool teachers’ assessments using the The Strengths and Difficulties Questionnaire (SDQ). Their assessments identify problems in different areas. Assessment from both parents and preschool teachers may therefore provide the Child Health Services (CHS) a better opportunity to detect early signs of health problems and initiate health promotive measures.

    Purpose: The aim was to map parents’ and preschool teachers’ assessment of three year old children's mental health problems using the SDQ as part of a broad routine health assessment.

    Methods: The study had a cross-sectional design, a consecutive data collection method and a consecutive data selection. Data consists of parents’ and preschool teachers’ SDQ assessments collected at the child’s three-year visit in the CHS between 2016-01-01 and 2018-06-30. Cohen´s kappa and Chi Square was used for data analysis.

    Results: 47 percent of the children were assessed by parents and preschool teachers as having difficulties. Hyperactivity-concentration difficulties were the most common. A low but significant agreement and differences were found between parents’ and preschool teachers’ assessments. Boys were more often assessed as having hyperactivity-concentration difficulties compared with girls.

    Conclusion: Assessments made by parents and preschool teachers using the SDQ complement each other with respect to children’s behavior in this data set. Access to both assessments provides the CHS-nurse with information that enables early detection and early intervention.

  • Kleinteich, Julia
    et al.
    Univ Tubingen, Ctr Appl Geosci, Tubingen, Germany.
    Hildebrand, Falk
    European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany.
    Bahram, Mohammad
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. Univ Tartu, Inst Ecol & Earth Sci, Dept Bot, Tartu, Estonia.
    Voigt, Anita Y.
    European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany;Jackson Lab Genom Med, Farmington, CT USA.
    Wood, Susanna A.
    Cawthron Inst, Coastal & Freshwater, Nelson, New Zealand;Univ Waikato, Environm Res Inst, Hamilton, New Zealand.
    Jungblut, Anne D.
    London Nat Hist Museum, London, England.
    Kupper, Frithjof C.
    Scottish Assoc Marine Sci, Oban, Argyll, Scotland;Univ Aberdeen, Oceanlab, Aberdeen, Scotland.
    Quesada, Antonio
    Autonomous Univ Madrid, Dept Biol, Madrid, Spain.
    Camacho, Antonio
    Univ Valencia, Cavanilles Inst Biodivers & Evolutionary Biol, Valencia, Spain.
    Pearce, David A.
    Univ Northumbria Newcastle, Fac Hlth & Life Sci, Dept Appl Sci, Newcastle Upon Tyne, Tyne & Wear, England;British Antarct Survey, Cambridge, England.
    Convey, Peter
    British Antarct Survey, Cambridge, England.
    Vincent, Warwick F.
    Univ Laval, Dept Biol, Quebec City, PQ, Canada;Univ Laval, Ctr Northern Studies, Quebec City, PQ, Canada.
    Zarfl, Christiane
    Univ Tubingen, Ctr Appl Geosci, Tubingen, Germany.
    Bork, Peer
    European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany;Max Delbruck Ctr Mol Med, Berlin, Germany;Univ Wurzburg, Dept Bioinformat, Wurzburg, Germany.
    Dietrich, Daniel R.
    Univ Konstanz, Human & Environm Toxicol, Constance, Germany.
    Pole-to-Pole Connections: Similarities between Arctic and Antarctic Microbiomes and Their Vulnerability to Environmental Change2017In: Frontiers in Ecology and Evolution, E-ISSN 2296-701X, Vol. 5, article id 137Article in journal (Refereed)
    Abstract [en]

    The global biogeography of microorganisms remains poorly resolved, which limits the current understanding of microbial resilience toward environmental changes. Using high-throughput 16S rRNA gene amplicon sequencing, we characterized the microbial diversity of terrestrial and lacustrine biofilms from the Arctic, Antarctic and temperate regions. Our analyses suggest that bacterial community compositions at the poles are more similar to each other than they are to geographically closer temperate habitats, with 32% of all operational taxonomic units (OTUs) co-occurring in both polar regions. While specific microbial taxa were confined to distinct regions, representing potentially endemic populations, the percentage of cosmopolitan taxa was higher in Arctic (43%) than in Antarctic samples (36%). The overlap in polar microbial OTUs may be explained by natural or anthropogenically-mediated dispersal in combination with environmental filtering. Current and future changing environmental conditions may enhance microbial invasion, establishment of cosmopolitan genotypes and loss of endemic taxa.

  • Höglund, Simon
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Kovacevic, Carlo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Mikrotransaktioner i tv-spel: En studie om spelarnas syn på mikrotransaktioner, och mikrotransaktioners påverkan på spelupplevelsen2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Försäljning av virtuella föremål i tv-spel genom mikrotransaktioner har blivit en vanlig affärsmodell inom spelindustrin. Mikrotransaktioner ger spelföretagen en fortsatt inkomstkälla även efter den initiala försäljningen av ett tv-spel. Det finns skilda åsikter kring mikrotransaktioner, då en av de största konsekvenserna med dessa är att det kan påverka hur spelföretagen designar tv-spelen. Vi har genomfört en kvalitativ studie genom att analysera kommentarer på ett onlineforum. Syftet med studien var att skapa förståelse för vad som motiverar spelare att genomföra mikrotransaktioner eller inte, samt hur mikrotransaktioner kan påverka spelupplevelsen. Studiens resultat visade att den främsta motivationen för att betala var på grund av tidsbrist, och spelare vill därför betala för att slippa investera tid i tråkiga spelmoment för att ta del av dessa föremål. Spelare som valde att inte genomföra dessa betalningar ansåg istället att en stor del av syftet med tv-spelet är att kämpa för att ta del avföremålen. Mikrotransaktioner kan ha både positiv och negativ påverkan på spelupplevelsen.

  • Nordlander, Henrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Mjöberg, Olof
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Användbarhet hos journalsystem: En fallstudie om upplevd användbarhet hos Cosmic på Akademiska Sjukhuset2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det har i Sverige gjorts stora åtaganden om att vara världsledande inom digitalisering av vården. Ett av de verktyg som möjliggör för vårdpersonalen att uppnå dessa åtaganden är de digitala journalsystem som idag används. I detta arbete genomför vi en fallstudie i syfte att undersöka hur användarna av det största digitala journalsystemet Cambio Cosmic upplever användbarheten hos systemet samt vilka förändringar och åtgärder som kan öka användbarheten. Datan i studien har insamlats med hjälp av fem intervjuer, tre läkare och två sjuksköterskor vid Akademiska sjukhuset som sedan analyserats utifrån modellen Quality in Use Integrated Measurement(QUIM) om användbarhet. En modell som används för att mäta användbarhet hos ett informationssystem. Resultatet av studien tyder på att Cosmic är användbart, men användbarheten är bristande vad gäller tillgänglighet av information och möjligheter att överblicka relevanta patientdata är undermålig. Studien visar att datorvana inte nödvändigtvis är synonymt med enkelhet att lära sig använda Cosmic, men att datorvana möjliggör en mer intuitiv navigering. Datorvana räcker däremot inte för att användaren ska bemästra Cosmic. Vi identifierar därför behovet av en introduktionsutbildning och regelbunden fortbildning inom systemet. Sett till hur användare söker kunskap om, och lösningar på, problem som kan uppstå i arbetet, försöker de ofta skapa egna lösningar än de Cosmic förser dem med. Vi identifierar i studien att en större delaktighet av användarna i vidareutvecklingen av systemet krävs för att nå bättre användbarhet. Vidare finner vi även att det bör implementeras utbredd funktionalitet och rutiner för återkoppling mellan användarna och ansvariga av systemet. Delaktigheten och återkopplingen ses som nära sammankopplade i resultatet. Återkoppling kan vara en del av, eller i helhet utgöra den delaktighet användarna efterfrågar och studien visar vara nödvändig. Det är dessa faktorer som studien sammanfattningsvis visar vara avgörande för att genom digitala journalsystem göra vården mer effektiv.

  • Elzvik Nyström, Klara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Rainfall Variation and Food Security in Malawi: A Panel Data Study with Valuable Insights from the Field2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study addresses the question of how climate variability, in terms of seasonal rainfall variation, might affect food security in Malawi. It hypothesizes that seasonal rainfall variation could cause food insecurity and that the consequences of weather hazards possibly differ within the country. An additional aim of this study is therefore to map local resilience in Malawi to estimate the adaptation ability by analyzing two subsamples. The hypothesis is tested by using a two-way fixed effect regression analysis and panel data for 28 districts in Malawi covering the years 2000, 2004, 2010 and 2015. This study finds no statistically significant effect of seasonal rainfall variation on children’s health for the examined years.

  • Lilja, Unni
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Tillväxt som mål, medel eller problem?: En kvalitativ studie av synen på ekonomisk hållbarhet inom Uppsalas samhällsplanering.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In light of the global climate crisis and the worldwide focus on ecological economy policies, this study aims to analyze what role the economy has in the quest for a sustainable future in Uppsala. How do urban planning documents as well as regional and municipality employees interpret and value economic sustainability in relation to ecological sustainability? The methodology includes two different types of document analysis as well as qualitative interviews. Finally, an ideal type analysis has been used to place the urban planning policies of Uppsala on a scale between ecological modernization theory and degrowth theory.

    The thesis shows a view of an economic sustainability in terms of economic growth as being the prerequisite for a sustainable development. Furthermore, the analysis shows an ambiguous portrayal of the relationship between the ecological and economic dimensions of sustainable development. The documents and employees depict the urban planning policies of Uppsala as being ecologically modernized. Despite relatively advanced climate policies, Uppsala has yet to articulate more bold views of a sustainable future.

  • Johansson, Emelie
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Elgström, Carina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Journalistyrkets anpassning till digitala medier: En studie i förändrade arbetsprocesser2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Hallstensson, Gustav
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Zalamans, Filip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    På lika villkor?: En utvärdering av svenska webbplatsers tillgänglighet2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    An important aspect of web development is making websites that are accessible for as manyusers as possible. In 2019, a new law is applied in Sweden which regulates the accessibilitydemands of websites according to an EU directive. This thesis presents an evaluation made onthe accessibility of 32 Swedish websites using the EU directive as a standard. The evaluationshows the most common accessibility problems. The majority of evaluated websites do notcomply with demands on text that can be magnified by 200%, demands on distinct markers offocused elements when navigating with the keyboard, demands on alternative descriptions ofcontent that is not text, and demands on code that validates.

  • Birch-Jensen, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Sylve, Alexander
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Hur ser framtiden ut för mainframes?2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This Essay is meant to look into the possibilities of the mainframe systems and whether they have a spot as one of the leading information system service providers in the foreseeable future. In conclusion, “How does the future of the mainframe look?”. Numerous big IT media providers such as news services, blogs and forums have written about the subject of whether the mainframe is going to last as one of the go-to platforms for core operation information systems. This essay is going to look into the actual state of the mainframe, and where the mainframe is heading in the future. It also delves further into what options there currently are to the mainframe platform and why these options might be better or worse than the mainframe.To answer these questions the essay will present the results of research from multiple large international companies such as IBM, Ericsson and Volvo. During these interviews questions have been answered about the current situation of the mainframe, why it is currently suffering from rumors about being on the brink of death, and what the companies actually think about the mainframe.The Essay does not look too deeply into the technical aspects of the mainframe platform, but more at the system as a whole, and its organizational impact in larger companies. To help do this the essay makes use of the DeLean and McLone model of information system success.As with all matters regarding the future, even this essay could not with certainty state exactly what will happen with the mainframe platform in the future. However multiple interesting conclusions were made about the future and alternatives of the mainframe.

  • Andersson, Ludvig
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Felin, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    AI inom vårdrådgivning: En attitydanalys på 1177 Vårdguidens sjuksköterskor2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Artificial intelligence is a technology that is becoming increasingly common in a number of fields, not least in order to streamline. In Sweden criticism has been directed at the healthcare industry and the long queues that overburden it. The study aims to investigate AI's potential in the healthcare industry in general and 1177 Vårdguiden in particular. Through an attitude analysis based on four interviews with 1177 Vårdguiden nurses, the survey concludes that AI has some potential in terms of administrative matters. When it comes to care-related cases, the attitude towards AI is more negative and its potential is not believed to be sufficient in order to replace the human factor.

  • Bogren, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Chu, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Svenska ungdomars attityd till implantat av mikrochip i kroppen2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Mikrochip, eller integrerad krets, är en samling av elektroniska kretsar på en mindre platta. De går att finna i nästan alla elektroniska produkter, såsom i mobiler eller självkörande bilar. Idag har denna teknik blivit så liten att människor kan implantera den i kroppen, där användningsområdena är många och fortfarande relativt outforskade. Ny teknik kommer ofta med positiva och negativa aspekter, en teknik som kan integreras med kroppen kan för individen kännas integritetskränkande, främmande eller obehagligt. Detta är en kvalitativ studie där vi genom intervjuer har undersökt vilka attityder ungdomar i Sverige har till implantat av mikrochip. Studien har identifierat vad ungdomar har för attityder och åsikter kring mikrochip i kontexten av deras egna privatliv, hälsa, vardagsliv och datasäkerhet.

  • Jonsson, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Relationen mellan människa och naturmiljö: En analys ur ett restorativt perspektiv av naturmiljöer i stadsdelen Rosendal2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Mental illness linked to stress and mental fatigue is increasingly common and some say that urban life is the cause. Science shows that experiences in nature may have a restorative affect on human well-being. The study emphasizes the importance of considering mental health in urban planning by including a restorative perspective. It examines the relationship between humans and their natural environment in the urban planning of Rosendal in Uppsala. Using document analysis, the study analyzes how restorative environments are represented in planning documents for Rosendal and identifies values related to natural environments. An observation of Solvallsparken based on eight restorative characteristics provides further understanding of how natural environments can be used as a restorative environment. The result shows that several different concepts are used to describe restorative environments which can be summarized as recreation, ecosystem services, and public environments. In essence, natural environments are linked to values concerning social gathering, biodiversity, attractiveness and in some cases, natural environments are given lower priority. Above all, the nearby forests adjacent to Rosendal can be used as restorative environments. Solvallsparken as a restorative environment is limited.

  • Lönnqvist, Izabella
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Wallsten, Filiph
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Chatboten Sally: Skillnader i förväntningar och resultat efter införandet av en chatbot hos Helsingborgs kommun2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Chatbotar används idag på en mängd olika sätt. Det är vanligt att chatbotar implementeras som kundservice i olika företag, men att använda sig av en chatbot i en kommun är inte lika förekommande. Chatboten Sally är den första i sitt slag som en servicebot i Helsingborgs kommun och svarar på frågor om Vuxenutbildningen. Denna uppsats är ett resultat av en kvalitativ studie vars syfte har varit att ta reda på vilka förväntningar som fanns på chatboten innan införandet och vad resultat blev. Intervjuerna har gjorts med utvecklarna av chatboten på Helsingborgs kommun, chef samt kommunvägledare på Kontaktcenter. Dessa har haft någon interaktion med chatboten. Studien har identifierat vad som motiverade kommunen till att skapa en chatbot och vad resultat blev, och kunskapsprodukten av den här studien är en genomgång av vad man kan tänka på när man skapar en bot i en kommun.

  • Eiderbrant, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Öppna möten och mellantunga dörrar: En studie av uttalsvariation på vokaler i Uppland2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie om uttalsvariation i Uppsalaområdet har gjorts med fokus på de tre vokalfonemen långt ä, långt ö och kort ö, samt prefixet er-, vars vokal är ett långt ä som varierar uttalet. Bakgrunden till detta ligger framför allt i egna iakttagelser, men även tidigare studier som gjorts från slutet av 1900-talet och framåt har visat dels på ett öppnare uttal av de långa vokalfonemen och på ett närmande av kort ö mot ett u.I ett försök att frammana dessa fyra variabler hos 12 informanter i två olika åldersgrupper har ett analyserbart material framställts och spelats in. Detta har sedan bearbetats och tolkats utifrån en generationsbaserad utvecklingsteori.Studien visar stark tendens till en utveckling av ett öppet uttal av både långa ä och ö, som båda förekommer i flera fall hos de yngre informanterna. Den kan dock inte uppvisa några tecken som talar för ett utbrett bruk av u-haltigt kort ö eller någon variation i uttalet av er-prefixet som mer eller mindre slutet.En särskilt sluten variant av långt ä, som i tidigare generationer varit vanlig i Stockhomsområdet är vanligare än den öppna i den äldre gruppen, även om dessa bara förekommer vid enstaka tillfällen och alltså inte kan påstås vara särskilt levande.Den enda utomspråkliga variabeln som har betydelse för realiseringen av de språkliga varianterna i denna studie är åldern, vilken också är den som uttrycker störst tecken på utvecklingen över tid.

  • Millbert, Sofia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Klimatanpassning i Uppsala kommun: En studie om fokusområden, begränsningar och samverkan2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Samhället står inför både samtida och framtida klimatförändringar. Det finns två primära tillvägagångssätt för att möta klimatförändringar. Dels kan man minska utsläppen och dels kan samhället vi lever i anpassas. Klimatanpassning är idag en aktuell fråga för Sveriges kommuner. En förordning för klimatanpassning väntas komma vilket kommer bidra till att frågan får mer gehör. En kommun som redan har börjat införa klimatanpassning i sin fysiska planering är Uppsala kommun. År 2017 fick de en utmärkelse om att de var högst rankade inom klimatanpassning enligt IVL Svenska Miljöinstitutets rankning. Denna studie syftar till att analysera Uppsala kommuns klimatanpassningsarbete med fokus på deras fysiska planering. Analysen kommer utgå från Uppsala kommuns fokusområden inom klimatanpassning, begränsningar inom deras klimatanpassningsarbete samt samverkan mellan Uppsala kommun och Länsstyrelsen Uppsala. Genom kvalitativa intervjuer och en dokumentanalys kommer studiens frågeställningar att besvaras. Något som framgår av studien är att Uppsala kommun har vatten som ett fokusområde när det kommer till deras klimatanpassningsarbete, vilket kan ses som naturligt i och med Fyrisåns centrala läge. Vidare framkom det att det kan urskiljas ekonomiska och institutionella begränsningar, något som kanske kan förhindras med den framtida förordningen för klimatanpassning. Slutligen framkom det att samverkan mellan Uppsala kommun och Länsstyrelsen Uppsala fungerar bra, där samverkan främst sker genom en regionalgrupp med klimatanpassningssamordnaren från Länsstyrelsen Uppsala i spetsen.

  • Malmback, Jonna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Uppsala - Sveriges bästa cykelstad: Länken mellan identiteten som cykelstad och varumärket cykelstaden2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Många städer försöker utmärka sig på den globala världsmarknaden genom att skapa varumärken för sin stad, så kallade city- och place branding, som översätts till marknadsföring på svenska. Dessa begrepp har fått relativt lite plats inom forskningen, vilket har resulterat i att konsekvenserna av att använda sig av city- och place branding är tämligen okända. Trots att begreppen är outforskade, finns ett fåtal teorier kring kopplingen mellan den identitet som finns på platsen med det brand, som översätts till varumärke på svenska, som skapats för platsen. Syftet med denna uppsats är att studera vilka konsekvenser det finns för cyklister i Uppsala när kommunen satsar på att skapa ett brand kring Sveriges bästa cykelstad, vilket kommer att göras med hjälp av kvalitativa studier. Resultatet i denna studie visar på att kommunen misslyckas med att förankra brandet i den platsidentitet som finns i staden, vilken kan härledas till kommunens arbete med visuella marknadsförningsmedel, istället för ett arbete utifrån cyklisterna.

  • Lundström, Cecilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Utbildning för slutanvändare: En fallstudie om utbildningen som gavs till anställda på Akademiska sjukhuset inför införandet av Cosmic R8.12019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    When the Swedish hospital Akademiska sjukhuset changed its journal system to Cosmic R8.1, training in the new journal system was given to the employees. The purpose of this work was to investigate the training methods and moments used to educate end users about the new journal system before its implementation, and also suggest possible improvement opportunities based on the existing support of the methods in scientific literature. Four interviews were conducted on three different people who have designed the programs, trained end users or have been involved in both design and education. The interviews were analyzed with a qualitative analysis and through a framework for end-user training based on Adaptive Structure Theory. The methods used were collaborative learning, learning from computers and learning with computers. These methods are supported by a few scientific articles, none of these sources have shown that they would be inferior to cathedral teaching. Two methods that have been supported by more scientific articles are observational learning and inactive learning, methods that are based on the reflection of others and their own behaviors.

  • Johansson, Kajsa
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Wenkler, Rebecka
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Information Systems.
    Vem vet var du är?: En kvalitativ studie om användares medvetenhet om säkerhetsrisker med platsdelning2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Platsdelning finns i många olika sociala medier idag och har blivit en populär funktion. Platsdelning kan vara väldigt användbart i olika situationer när det kommer till att lokalisera personer, men många är omedvetna om de säkerhetsrisker som kan komma till följd av platsdelning. Syftet med studien är att uppmärksamma de säkerhetsrisker som finns i samband med platsdelning och undersöka hur medvetna användare är om dessa. Fokus ligger på de tre mest använda sociala medierna i Sverige; Facebook, Instagram och Snapchat. Studien bygger på ett antal semistrukturerade intervjuer där frågor om användandet av sociala medier, platsdelning och kunskap om säkerhetsrisker resulterar i möjligheten att svara på studiens forskningsfråga. Analysen gjordes utifrån ett teoretiskt ramverk sammansatt av flera grenar inom informationssäkerhet, bland annat C.I.A-triangeln. Informanterna diskuterade problem såsom förföljelse och möjlighet till inbrott när det syntes att man inte var hemma. Slutsatser som kan dras av studien är att flera av informanterna inte såg platsdelning som en säkerhetsrisk, en del för att de inte ansåg sig själva tillräckligt viktiga för att det skulle bli ett hot och andra för att de inte hade kunskapen om vilka säkerhetsrisker som kunde uppstå.

  • Hellsing, Edvin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Axenborg Wallér, William
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Relationen kommunikationsbyrå–kund: En kvalitativ studie om vad medarbetare vid kommunikationsbyråer och deras kunder upplever som centralt i sin relation2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of the study is to develop knowledge about what employees in communication agencies and its customers perceive as central to the relationship. The research questions are: What do communication agencies experience as central to the relationship with customers? and What do customers experience as central in the relationship with communication agencies?

    Based on Social Exchange Theory (SET), supplemented with Behaviorally Driven Relationship Marketing Theory (BRM), we have investigated what is central in the communication agency– customer.

    As a basis for achieving our goal, we have in total conducted semi-structured interviews with nine people, six people from a communication agency and three of their customers. We have interviewed employees from both a communication agency and from customers to achieve a more nuanced view of the research problem. In our thematic analysis of our interview transcripts we found the concepts Phases in the Relationship, View of the Relationship, and Cooperation as central aspects. Through these aspects we illustrate the respondents' perceptions of what is central in the relationship.

    The study's results indicate that the longer the relationship is, the better the cooperation gets, which enables both parts possibilities to achieve desired product. In addition, a crucial part of this seems to be the start up phase and an equal view of the relationship. Furthermore, an ongoing relationship should be characterized with trust, commitment and two-way communication.

  • Modin, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    An Interest Rate Benumbed: Evidence from a structural VAR; can a structural break be found in recent monetary policy transmission?2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The reliability of monetary policy as an economic stabilisation tool depends on the understanding of the empirical effects of policy intervention on macroeconomic aggregates. Since investigating the interdependencies between macroeconomic variables necessarily involves studying their interactions over time, time series analysis is an important tool. This thesis sets out to examine the presence and effects of nonstationarity in the form of a structural break in a basic VAR of four endogenous variables. Specifically, the transmission of a monetary policy shock on the macroeconomic aggregate of 11 Euro Area countries is estimated for the period 1999–2017, employing variables based on previous studies. A Quandt-Andrews breakpoint test is used to identify the break date, and a comparison is made between the periods. This study finds support for the presence of a break in the regression estimate from the breakpoint test, although the reults from the IRFs cannot be shown to be statistically significant, nor to be bias-free.

  • Reinthaler, Eva M.
    et al.
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    Graf, Elisabeth
    Helmholtz Zentrum Munchen, Inst Humangenet, Munich, Germany.
    Zrzavy, Tobias
    Med Univ Vienna, Ctr Brain Res, Vienna, Austria.
    Wieland, Thomas
    Helmholtz Zentrum Munchen, Inst Humangenet, Munich, Germany.
    Hotzy, Christoph
    Kopecky, Chantal
    Med Univ Vienna, Dept Internal Med 3, Div Nephrol & Dialysis, Vienna, Austria.
    Pferschy, Sandra
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    Schmied, Christiane
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    Leutmezer, Fritz
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    Keilani, Mohammad
    Med Univ Vienna, Rehabil & Occupat Med, Dept Phys Med, Vienna, Austria.
    Lill, Christina M.
    Univ Lubeck, Inst Neurogenet & Cardiogenet, Lubeck Interdisciplinary Platform Genome Analyt, Lubeck, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Focus Program Translat Neurosci FTN, Dept Neurol, Mainz, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Neuroimaging Ctr NIC, Mainz, Germany.
    Hoffjan, Sabine
    Ruhr Univ Bochum, Dept Human Genet, Bochum, Germany.
    Epplen, Joerg T.
    Ruhr Univ Bochum, Dept Human Genet, Bochum, Germany;Univ Witten, Fac Hlth, ZBAF, Herdecke, Witten, Germany.
    Zettl, Uwe K.
    Univ Rostock, Neuroimmunol Sect, Dept Neurol, Rostock, Germany.
    Hecker, Michael
    Univ Rostock, Neuroimmunol Sect, Dept Neurol, Rostock, Germany.
    Deutschlaender, Angela
    Jeweils Mayo Clin, Dept Neurol, Jacksonville, FL USA;Jeweils Mayo Clin, Dept Clin Genom, Jacksonville, FL USA;Jeweils Mayo Clin, Dept Neurosci, Jacksonville, FL USA.
    Meuth, Sven G.
    Univ Munster, Dept Neurol, Munster, Germany.
    Ahram, Mamoun
    Univ Jordan, Sch Med, Dept Physiol & Biochem, Amman, Jordan.
    Mustafa, Baha
    Univ Jordan, Sch Med, Dept Physiol & Biochem, Amman, Jordan.
    El-Khateeb, Mohammed
    Natl Ctr Inst Diabet, Endocrinol & Genet NCDEG, Amman, Jordan.
    Vilarino-Guell, Cartes
    Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.
    Sadovnick, Dessa
    Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.
    Zimprich, Fritz
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    Tomkinson, Birgitta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Strom, Tim
    Helmholtz Zentrum Munchen, Inst Humangenet, Munich, Germany.
    Kristoferitsch, Wolfgang
    SMZ Ost Donauspital, Karl Landsteiner Inst Neuroimmunol & Neurodegener, Vienna, Austria;SMZ Ost Donauspital, Inst Neuroimmunol & Neurodegenerat Disorders, Vienna, Austria.
    Lassmann, Hans
    Med Univ Vienna, Ctr Brain Res, Vienna, Austria.
    Zimprich, Alexander
    Med Univ Vienna, Dept Neurol, Vienna, Austria.
    TPP2 mutation associated with sterile brain inflammation mimicking MS2018In: NEUROLOGY-GENETICS, ISSN 2376-7839, Vol. 4, no 6, article id UNSP e285Article in journal (Refereed)
    Abstract [en]

    Objective To ascertain the genetic cause of a consanguineous family from Syria suffering from a sterile brain inflammation mimicking a mild nonprogressive form of MS.

    Methods We used homozygosity mapping and next-generation sequencing to detect the disease-causing gene in the affected siblings. In addition, we performed RNA and protein expression studies, enzymatic activity assays, immunohistochemistry, and targeted sequencing of further MS cases from Austria, Germany, Canada and Jordan.

    Results In this study, we describe the identification of a homozygous missense mutation (c.82T>G, p.Cys28Gly) in the tripeptidyl peptidase II (TPP2) gene in all 3 affected siblings of the family. Sequencing of all TPP2-coding exons in 826 MS cases identified one further homozygous missense variant (c.2027C>T, p.Thr676Ile) in a Jordanian MS patient. TPP2 protein expression in whole blood was reduced in the affected siblings. In contrast, TPP2 protein expression in postmortem brain tissue from MS patients without TPP2 mutations was highly upregulated.

    Conclusions The homozygous TPP2 mutation (p.Cys28Gly) is likely responsible for the inflammation phenotype in this family. TPP2 is an ubiquitously expressed serine peptidase that removes tripeptides from the N-terminal end of longer peptides. TPP2 is involved in various biological processes including the destruction of major histocompatibility complex Class I epitopes. Recessive loss-of-function mutations in TPP2 were described in patients with Evans syndrome, a rare autoimmune disease affecting the hematopoietic system. Based on the gene expression results in our MS autopsy brain samples, we further suggest that TPP2 may play a broader role in the inflammatory process in MS.

  • Bergström, Ida
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Uggla, Laura
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Hur är det att vara god man till ensamkommande barn?: En kvalitativ studie om hur gode män upplever uppdraget som god man till ensamkommande barn i Sverige2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Mycket forskning har bedrivits med syfte att förstå ensamkommande barn i relation till gode män, i samband med flykten till ett främmande land. Vad som inte studerats i samma utsträckning är gode män till ensamkommande barn och deras perspektiv på uppdraget som god man. Denna uppsats ämnar därför att studera de gode männens upplevelser av uppdraget som god man till ensamkommande barn. Uppsatsen fokuserar på de gode männens upplevelser av relationen med barnet, kontakten med olika myndigheter, hur de upplever att uppdraget som roll karaktäriseras och hur gode männens motivation till uppdraget påverkas av deras upplevelse av rollen som god man. Förhoppningen med studien är att få en djupare inblick i hur gode män upplever uppdraget som god man till ensamkommande barn, samt öka förståelsen för den som engagerar sig. Vi hoppas även att studien ska öppna upp för diskussion i det svenska samhället kring huruvida godmanskapet, som det är utformat idag, verkligen är lämpligt i bemötandet av ensamkommande barn. Genom kvalitativa intervjuer har 12 informanter med erfarenhet som god man till ensamkommande barn i Sverige delat med sig av berättelser från deras tid som god man. Den insamlade empirin analyserades med hjälp av en kvalitativ innehållsanalys med syftet att se hur sociologen Johan Asplunds teorier om social responsivitet kunde genomsyra materialet. Dessutom har Arlie Hochschilds och Mikael Allvins teorier använts som ett komplement till Johan Asplunds teorier. Resultatet visar att gode män upplever arbetsuppgifterna inom uppdraget som otydliga, vilket påverkar sociala interaktioner med olika parter inom uppdraget, samt den gode mannens välmående.

  • Ensor, Jonathan Edward
    et al.
    Stockholm Environment Institute, Department of Environment and Geography, University of York.
    Wennström, Patrick
    Department of Urban and Rural Development, Swedish University of Agricultural Sciences.
    Anil, Bhatterai
    Department of Geography, University of Toronto.
    Nightingale, Andrea Joslyn
    Department of Urban and Rural Development, Swedish University of Agricultural Sciences.
    Eriksen, Siri
    International Environment and Development Studies, Norwegian University of Life Sciences.
    Sillmann, Jana
    CICERO Center for International Climate Research.
    Asking the right questions in adaptation research and practice: Seeing beyond climate impacts in rural Nepal2019In: Environmental Science and Policy, ISSN 1462-9011, E-ISSN 1873-6416, Vol. 94, p. 227-236Article in journal (Refereed)
    Abstract [en]

    Adaptation research and practice too often overlooks the wider social context within which climate change is experienced. Mainstream approaches frame adaptation problems in terms of the consequences that flow from biophysical impacts and as a result, we argue, ask the wrong questions. A complementary approach gaining ground in the field, foregrounding the social, economic and political context, reveals differentiation in adaptation need, and how climate impacts interconnect with wider processes of change. In this paper, we illustrate how this kind of approach frames a different set of questions about adaptation using the case of Nepal. Drawing on fieldwork and a review of literature, we contrast the questions that emerge from adaptation research and practice that take climate risk as a starting point with the questions that emerge from examination of contemporary rural livelihoods. We find that while adaptation efforts are often centred around securing agricultural production and are predicated on climate risk management, rural livelihoods are caught in a wider process of transformation. The numbers of people involved in farming are declining, and households are experiencing the effects of rising education, abandonment of rural land, increasing wages, burgeoning mechanisation, and high levels of migration into the global labour market. We find the epistemological framing of adaptation too narrow to account for these changes, as it understands the experiences of rural communities through the lens of climate risk. We propose that rather than seeking to integrate local understandings into a fixed, impacts-orientated epistemology, it is necessary to premise adaptation on an epistemology capable of exploring how change occurs. Asking the right questions thus means opening up adaptation by asking: ‘what are the most significant changes taking place in people's lives?’, along with the more standard: ‘what are the impacts of climate change?’ Viewing adaptation as occurring between and within these two perspectives has the potential to reveal new vulnerabilities and opportunities for adaptation practice to act upon.

  • Wendel, Jessica
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Andraspråkselever i styrdokumenten. En jämförande analys mellan Lgr80 och Lgr11.2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Huvudsyftet med uppsatsen är att jämföra de allmänna delarna från läroplanerna Lgr80 och Lgr11 för att undersöka om och hur andraspråkselever synliggörs i styrdokumenten. Delsyftet är att undersöka om och hur kursplanerna i svenska som främmande språk från Lgr80 och svenska som andraspråk i Lgr11 skiljer sig från varandra i avseende till kunskapskrav.

     

    Frågeställningarna som undersöks är följande:

    • Skiljer sig de allmänna delarna i läroplanerna Lgr80 och Lgr11 i synen på andraspråkselever? I så fall, hur?

    • Finns det skillnader och likheter mellan kursplanerna i svenska som främmande språk i Lgr80 och svenska som andraspråk i Lgr11? Om så är fallet, hur ser dessa skillnader och likheter ut?

    Metoden som används är en kvalitativ innehållsanalys som kompletteras med ett diskursanalytiskt perspektiv och ett konstruktivistiskt perspektiv. Materialet som analyseras är utöver de allmänna delarna av läroplanerna även kursplanerna med speciellt fokus på innehåll som rör årskurs F-3. Uppsatsen utgår från ett läroplansteoretiskt perspektiv där begrepp som läroplanskoder och formuleringsarena är centrala.

     

    Resultatet visar att mångkulturella identiteter så som andraspråkselever inte finns framskrivna i framförallt Lgr11, medan Lgr80 har framskrivna andraspråkselever som kan tolkas som endimensionella och saknar komplexitet. Resultat som rör Lgr11 ligger i linje med tidigare forskning som utförts. Kursplanerna som jämförs har både likheter och skillnader, den främsta likheten är kopplad till den rationella läroplanskoden som innebär att läroplanen bör utgå från individen och individens lärande (Lundgren, 1989, s. 84). Den största skillnaden är att kursplanen i svenska som främmande språk ses som ett komplement till den reguljära svenskundervisningen, medan svenska som andraspråk är en egen kursplan som täcker hela grundskolan upp till åk 9. I diskussionen jämförs resultatet med tidigare forskning, metoden samt teoretiska utgångspunkter. Även pedagogiska konsekvenser diskuteras i slutet av uppsatsen.

     

    Nyckelord: formuleringsarena, läroplanskoder, läroplansteori, andraspråkselever.

  • Korshed Lejon, Kani
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Millqvist, Ludvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Tyst Kunskap: En kvalitativ studie om hur tyst kunskap tas tillvara på inom detaljhandeln2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In a society where knowledge is more and more valuable, every moment that knowledge can be shared between colleagues is of great importance. According to our earlier personal experiences, we thought that organizations prioritised explicit knowledge and not tacit knowledge. 

    To contribute to knowledge on the subject we choose to do a study where we focused on the experiences of coworkers that works in shops. The purpose of the study then became: “to investigate how tacit knowledge is made use of in shops from the perspective of coworkers”. With the purpose in mind, we created two questions: “How does the coworkers of shops perceive that tacit knowledge occurs on their workplace?” and “how does coworkers perceive that they share their tacit knowledge”? 

    The study is made with a qualitative approach the collection of data has been made through seven semistructured interviews with coworkers. When we analyzed the empiric material, we’ve analyzed it through the theory of situated learning by Lave and Wenger that is included in the sociocultural perspective. Some things that the result showed according to our interpretation was observation and social interactions with other colleagues is the most common way that tacit knowledge can be shared through on the respondent’s workplaces, that the organizations do have a plan to make use of the explicit knowledge in greater extent than tacit knowledge, the respondents views trust as an important factor when it comes to sharing their tacit knowledge. 

  • Cauchard, Laure
    et al.
    Univ Montreal, Dept Sci Biol, Montreal, PQ, Canada.
    Angers, Bernard
    Univ Montreal, Dept Sci Biol, Montreal, PQ, Canada.
    Boogert, Neeltje J.
    Univ Exeter, Ctr Ecol & Conservat, Penryn, England.
    Lenarth, Melissa
    Univ Lausanne, Dept Ecol & Evolut, Lausanne, Switzerland.
    Bize, Pierre
    Univ Lausanne, Dept Ecol & Evolut, Lausanne, Switzerland;Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland.
    Doligez, Blandine
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ Lyon 1, Dept Biometry & Evolutionary Biol, CNRS, Villeurbanne, France.
    An Experimental Test of a Causal Link between Problem-Solving Performance and Reproductive Success in Wild Great Tits2017In: Frontiers in Ecology and Evolution, E-ISSN 2296-701X, Vol. 5, article id 107Article in journal (Refereed)
    Abstract [en]

    Recent studies have uncovered relationships between measures of various cognitive performances and proxies of fitness such as reproductive success in non-human animals. However, to better understand the evolution of cognition in the wild, we still have to determine the causality of these relationships and the underlying mechanisms. The cognitive ability of an individual may directly influence its ability to raise many and/or high quality young through for example its provisioning ability. Conversely, large and/or high quality broods may lead to high parental motivation to solve problems related to their care. To answer this question, we manipulated reproductive success through brood size and measured subsequent problem-solving performance in wild great tit parents. Our results show that brood size manipulation did not affect the probability to solve the task. Moreover, solver pairs fledged more young than non-solver pairs independently of brood size treatment in one of the two experimental years and they showed higher nestling provisioning rate in both years. Overall, it shows that problem-solving performance was not driven by motivation and suggest that problem-solvers may achieve higher fledging success through higher provisioning rates. Our study constitutes a first key step toward a mechanistic understanding of the consequences of innovation ability for individual fitness in the wild.

  • Gustafson, Elisabet K.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Larsson, Therese
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Danielson, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Controlled outcome of Hirschsprung's disease beyond adolescence: a single center experience2019In: Pediatric surgery international (Print), ISSN 0179-0358, E-ISSN 1437-9813, Vol. 35, no 2, p. 181-185Article in journal (Refereed)
    Abstract [en]

    PurposeThe aim of this study was to assess the function and quality of life of Hirschsprung's Disease (HD) beyond adolescence and relate it to matched controls.MethodsAll 203 patients diagnosed with HD at our department from 1961 to 1995 were identified. 21 had died, 43 had unclear diagnosis and 16 could not be traced. The remaining 123 patients were sent bowel function and SF-36 quality of life questionnaires. 69 patients (mean age 37.8, range 22-58, 13 female) responded and were matched with 138 age and sex-matched controls.ResultsFunction: HD-patients had significantly higher number of bowel movements per week, higher incidence of soiling, urgency, permanent stomas, use of laxatives, enemas and loperamide. HD-patients also scored significantly lower in their satisfaction with their bowel function. There was, however, no significant difference in Miller Incontinence score.QOL: HD-patients reported a significantly higher incidence of negative impact by their bowel function on daily life, social interaction and ability to go on vacation. There were no significant differences in SF-36-scores.ConclusionsBowel function has a lifelong negative impact on the lives of patients with HD. This strongly indicates a need for structured follow-up beyond adolescence.

  • Public defence: 2019-03-06 09:15 C8:301, Uppsala
    Pietrini, Alberto
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.
    Statistical processing of Flash X-ray Imaging of protein complexes2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Flash X-ray Imaging (FXI) at X-ray Free Electron Lasers (XFELs) is a promising technique that permits the investigation of the 3D structure of molecules without the need for crystallization, by diffracting on single individual sample particles.

    In the past few years, some success has been achieved by using FXI on quite large biological complexes (40 nm-1 μm in diameter size). Still, the desired dream-goal of imaging a single individual of a molecule or a protein complex (<15 nm in diameter size) has not been reached yet. The main issue that prevented us from a complete success has been the low signal strength, almost comparable to background noise. That is particularly true for experiments performed at the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS).

    In this thesis, we provide a brief review of the CXI instrument (focusing on experiments there performed) and present a statistical method to deal with low signal-to-noise ratios. We take into account a variety of biological particles, showing the benefits of estimating a background model from sample data and using that for processing said data. Moreover, we present the results of some computer simulations in order to explore the limits and potentials of the proposed approach.

    Last, we show another method (named COACS) that, being fed with the previous findings from the background model, helps obtaining clearer results in the phase retrieval problem.

    List of papers
    1. Artifact reduction in the CSPAD detectors used for LCLS experiments
    Open this publication in new window or tab >>Artifact reduction in the CSPAD detectors used for LCLS experiments
    2017 (English)In: Journal of Synchrotron Radiation, ISSN 0909-0495, E-ISSN 1600-5775, Vol. 24, p. 1092-1097Article in journal (Refereed) Published
    National Category
    Biophysics
    Identifiers
    urn:nbn:se:uu:diva-328543 (URN)10.1107/S160057751701058X (DOI)000408902800025 ()28862634 (PubMedID)
    Projects
    eSSENCE
    Available from: 2017-07-18 Created: 2017-08-25 Last updated: 2019-01-14Bibliographically approved
    2. A statistical approach to detect protein complexes at X-ray free electron laser facilities
    Open this publication in new window or tab >>A statistical approach to detect protein complexes at X-ray free electron laser facilities
    Show others...
    2018 (English)In: Communications Physics, E-ISSN 2399-3650, Vol. 1, p. 92:1-11, article id 92Article in journal (Refereed) Published
    National Category
    Biophysics
    Identifiers
    urn:nbn:se:uu:diva-369876 (URN)10.1038/s42005-018-0092-6 (DOI)000452676300003 ()
    Projects
    eSSENCE
    Available from: 2018-12-07 Created: 2018-12-17 Last updated: 2019-01-17Bibliographically approved
    3. Using convex optimization of autocorrelation with constrained support and windowing for improved phase retrieval accuracy
    Open this publication in new window or tab >>Using convex optimization of autocorrelation with constrained support and windowing for improved phase retrieval accuracy
    2018 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 26, p. 24422-24443Article in journal (Refereed) Published
    National Category
    Computational Mathematics Biophysics
    Identifiers
    urn:nbn:se:uu:diva-360037 (URN)10.1364/OE.26.024422 (DOI)000444705000012 ()30469561 (PubMedID)
    Projects
    eSSENCE
    Available from: 2018-09-05 Created: 2018-09-09 Last updated: 2019-01-14Bibliographically approved
  • Meyer-Rodrigues, Sims
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Recruiting Cyclists in Uppsala: Why do exchange students cycle?2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The current trend of emissions from the transport sector is unsustainable. To increase cycling mitigates these emissions, while also actively promoting health and alleviating congestion within cities. However, the clear benefits from cycling, along with efforts from municipalities around the world to promote cycling, have not translated in a sufficient change in behavior to reverse the global trends in emissions. Rather than looking at individual behavior, Social Practice Theory (SPT) is concerned with the practice (of cycling) as a whole. Primarily through interviews with international students about their experiences cycling and how they picked up cycling in Uppsala, voted best bike city in Sweden in 2018, I present an analysis of the recruitment process, and the overall practice of cycling in Uppsala through the lens of SPT. In this thesis I found that the pervasiveness of cycling throughout Uppsala and the social networks created by exchange students work together to recruit practitioners and spread the practice of cycling.

  • Biyikli, Güliz
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Modersmålsundervisning i turkiska: En studie om vad modersmålslärare och modersmålselever i turkiska har för syn på turkiska modersmålsundervisningen2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Ahnesjö, Ingrid
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Berglund, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Forsgren, Elisabet
    Norsk institutt for naturforskning i Trondheim, Norway.
    Karlsson, Anna
    Enheten för biologisk mångfald och områdesskydd, Havs och Vattenmyndigheten, Göteborg.
    Kvarnemo, Charlotta
    Zoologi, Göteborgs universitet, Göteborg.
    Magnhagen, Carin
    Fiskbiologi, Sveriges lantbruksuniversitet (SLU), Umeå.
    Rosenqvist, Gunilla
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development. Etologi, NTNU, Trondheim, Norway.
    Östlund Nilsson, Sara
    Nasjonalbiblioteket, Oslo, Norway.
    En beteende-ekologisk forskningsperiod på Klubbans biologiska station: Rapport från återträff med Doktorer som disputerade (1983-2001) på avhandlingar med fältarbete på Klubbans Biologiska station. I en värld av kantnålar, stubbar, spiggar och nudingar.2018Report (Other (popular science, discussion, etc.))
    Abstract [en]

    We had the fortune as PhD-students and scientists in Animal Ecology at Uppsala University, to spend joyful and creative field work summers at Klubban Biological Station, during the 1980-90’s. A reunion in June 2018 resulted in this report highlighting research on pipefishes, gobies, sticklebacks and nudibranchs. Our research on these animals have provided novel insights and knowledge of the process of sexual selection and paternal care. These animals have, in many aspects, now become model organisms in evolutionary behavioral ecology in marine environments. Our list of publications provides many examples of how environmental factors influence how sexual selection and mate choice operate, how predictors like potential reproductive rates, operational sex ratios work and how male parental care is prominent in influencing selection. This research, that started at Klubban, has broadened our understanding of the ecological importance of shallow marine areas. The evolutionary understanding of how males and females can behave and how adaptive traits are selected in interaction with social and an increasingly changing ambient environment is in focus in our continued scientific endeavors. We have happily compiled this report illustrating how science and scientist can stimulate each other at a wonderful place like Klubban Biological Station, with the access to amazing organisms like pipefishes, gobies, sticklebacks and nudibranchs.

  • Söderlund Castillo, Emelie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    "Jag vill inte sträckas ut": En studie om översättning av Pippi Långstrump på kinesiska2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis uses the problems and strategies categorised by Mona Baker for non-equivalence in translations on word level. These theories are applied on a material made up of selected parts from the book “Boken om Pippi Långstrump” – Chang wazi Pipi《长袜子皮皮》– the source text by Astrid Lindgren (1952) in translation to Chinese by Li Zhiyi 李之义 (1983). The text is analysed through a close-read and examples are given of Bakers strategies for translation. Additional categories are identified in the text, developed by alumni of sinology at the department of linguistics at Uppsala University. In addition to these pre-exiting categories, an additional eight have been identified. The four problems were: the use of the nonsense genre, the use of semantic/pragmatic fouls, the use of sociolectic neologisms and difference in written language. The four identified strategies were: translating by a less neutral/more expressive word, translating by idiom, translation by paraphrase using a related pronunciation and translation by transliteration. These can be argued to be particularly common, for the specific cases of translations to Chinese, translation of children’s literature, and translation of the specific work.

  • Salles, Arleen
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    Stahl, Bernd
    Bjaalie, Jan
    Domingo-Ferrer, Josep
    Rose, Nikolas
    Rainey, Stephen
    Spranger, Tade
    Bitsch, Lise
    Christen, Marcus
    Farisco, Michele
    Opinion and Action Plan on 'Data Protection and Privacy'2017Other (Other academic)
    Abstract [en]

    A fuller understanding of the human brain, better diagnoses and treatment of brain disorders, as well as the development of new brain-like technologies are all goals of the Human Brain Project. Realizing these goals requires the collection, storage, curation, and analysis of data of various sorts over extended periods of time.

    Securing privacy interests and advancing data protection measures are key concerns of the Human Brain Project. Their importance was recognized during the proposal development, taken up by the Ethics and Society Subproject (SP12) and reinforced by the Ethics Review in Jan 2015. The HBP needs to comply with national and European data protection legislation. But it is clear that the HBP must go beyond existing legal protections and show not only that it is ethically sensitive to privacy concerns even when such concerns fall outside regulatory frameworks, but also that it makes appropriate use of data and is able to identify and respond to new, unanticipated threats to privacy as they emerge. This document expresses the opinion concerning data protection and privacy by those involved in the Ethics and Society section of the HBP. This includes the members of the sub-project on Ethics and Society (SP12), members of the Ethics Advisory Board and the Ethics Rapporteurs. We identify some of the main privacy-related concerns within HBP, articulate the basic ethical principles that should guide examination of the issues, and present a brief review of the history of data protection and regulation in Europe, focusing on the current state of such regulation. While aware that misuse of the information must be prevented, we are mindful that a form of privacy protection that would prohibit use of any medical or other records for research would stifle medical and scientific progress making it impossible to achieve expected benefits to health that are in the public interest. Therefore, we offer final recommendations that are intended to minimize potential risks while securing the public benefit anticipated from HBP research.

    Finally, it is worth noting that there is a more general context to current debates on data protection and privacy. A variety of well publicised events have revealed the extent to which the security apparatuses of different national states acquire covert access to data stored on the internet and mine it in various ways in the course of their work. These revelations influence how citizens think about and how policymakers legislate data protection.

    The structure of the the Opinion is as follows: it starts with a description of some of the key privacy challenges and concerns raised by the HBP. The Opinion then describes conceptual and empirical research on privacy and data protection undertaken in the context of the HBP. It outlines technical options and the regulatory environment within which the HBP operates. The Opinion concludes with a set of recommendations to the HBP.

  • Fathimah, Fida
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    The Extractive Institutions as Legacy of Dutch Colonialism in Indonesia: A Historical Case Study2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    While some countries are thriving in political stability and economicprosperity, others are struggling with political instability and poverty. The fundamental difference between the successful and the failed nations boildown to their institutions, as stated by Acemoglu and Robinson in their influential institutional economics work, “Why Nations Fail”. Inclusive institution is the reason why some countries achieved economic success and prosperity because they allow the population to participate and take advantage of the economic activities while extractive institutions hinder it incase of failed nations.

    The purpose of this study is to explore more closely how extractive institutions persist in an ex-colonised country in spite of institutional drift andthe political disruptions of post-colonial governments avowedly vying to rid the present of the past. Indonesia is chosen as the subject for this historical desk research case study wherein the relevant history surrounding thecolonial period and the subsequent development will be explored andanalysed through the lens of secondary literature. In addition to being based on textual evidence, the institutional economics approach will be used as a theoretical framework to break down the social, economic, and political aspects of the history. Furthermore, the mechanism of how the institutions evolve will be seen through the political development framework. The result will show that patrimonialism is present as an extractive feature in both modern and colonial Indonesia and how it has been sustained after independence. This study also suggests other extractive features as a legacy ofthe Dutch colonialism that is separate from the native tradition and customs which are Javacentrism and racism in the form of social stratification between races as a result of colonial policies.

  • Kihlberg, Emelie
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. University of medicine and pharmacy, Ho Chi Minh City.
    Rosenkvist, Nadine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. University of medicine and pharmacy, Ho Chi Minh City.
    Vietnamese nursing students' knowledge in Cardiopulmonary resuscitation (CPR) and perceptions of training in CPR2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background

    Cardiopulmonary resuscitation (CPR) increases significantly the chance of survival in cases of a cardiac arrest. The ability to respond quickly and effectively to a cardiac arrest rests on nurses being competent, prepared and up-to-date. Nursing student’s knowledge in CPR and perceptions of their own training are crucial for the pursuit of the education of professional nurses. 

     

    Aim

    Investigate the prerequisites for a good care of patients in need of CPR by assessing  Vietnamese nursing students' knowledge in CPR as well as their perceptions on their education in CPR.   

     

    Method

    A quantitative, cross sectional-study was conducted. A modified version of a questionnaire developed by the Swedish council of CPR was used. Nursing students at University of Medicine and Pharmacy in Ho Chi Minh City were asked to participate. The gathered data were analyzed with descriptive statistics, t-test and chi2 -test.

     

    Result

    The participants answered right on 41 % of the questions (571/1404). The mean-score was 5.25 and the score ranged from 0 to 9 out of 13 points on the questionnaire. Participants answered correctly on most questions regarding basic CPR and were foremost wrong about questions regarding defibrillation. There was no association between a high result on the questionnaire and students rating a high grading on preparedness and/or satisfaction. No significant difference could be found based on gender.

     

    Conclusion

    The knowledge in CPR, based on this survey, is generally low. One plausible explanation could be that the questionnaire did not fit the education of the participants.