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  • Lundberg, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Implementation of Fast Real-Time Control of Unstable Modes in Fusion Plasma Devices2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In recent years, multi-core graphics processing units (GPUs) have been increasingly used by researchers for other purposes than rendering graphics. This thesis presents the implementation of GPU computing for real-time control of plasma instabilities known as resistive wall modes at the EXTRAP T2R fusion plasma device. A NVIDIA GPU is installed in the device plasma control system. Using the CUDA parallel computing platform, PID and LQG control algorithms are developed for the GPU. It is shown that computation times decrease with up to 80 % for the LQG algorithm and 33 % for the PID algorithm if computations in the control system are shifted from the central processing unit (CPU) to the GPU. The gains of GPU utilization are limited by latencies introduced by the CPU-GPU interaction. To better exploit the potential of the GPU, a zero-copy method is proposed, in which the GPU is allowed to perform read and write operations on CPU memory. 

  • Alm, Tobias
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Energieffektivisering av Saltsjöbaden Grand Hotell2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In a hotel building there are many processes which consume energy, such as lightning and drive fan motor in the ventilation system. These processes needs supplied with electricity. The building is a big consumer of heat. The heating system is supplied with heat pumps and oil. The consumption of electricity is about 1700 MWh and 350 MWh of oil. This thesis affects an energy saving investigation for a hotel and the purpose is to find measures to reduce the energy consumption for this building. The method for the investigation consisted of three steps. First step was to establish how much energy the building consumes today. Second step was to find measures which could be implemented and the third was to calculate the energy saving potential for each measure. If all investigated measures will be implemented the Hotel could save up to 40 % energy. If only the economical and easy measures would be implemented the hotel could save 30 % energy. The easiest measure was to change some parameters in the control system so the oil burners did not go at all times. With that change and a change in the control system for ventilation to reduce the hours the ventilation are on gave reduced energy consumption with 20 %. The economical investments were converting one of the oil burners to an extra heat pump and to change all old lighting to a new LED-Lighting.

  • Hasan, MD. Shakib
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Reactive Power Control for Voltage Management2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis presents methods for voltage management in distribution systems with high photovoltaic (PV) power production. The high PV penetration leads to both new challenges such as voltage profile violation and reverse power flow, and also new opportunities. Traditionally, the voltage control in the distribution network is achieved by common devices in the networks such as capacitor banks, static synchronous compensators (STATCOMs) and on-load tap changers (OLTCs). This thesis has considered existing reactive power capable solar PV inverters together with STATCOMs to provide voltage support for the distribution network. In this thesis, two effective coordination methods using the STATCOM and PV inverters are developed in order to study their interaction and how they together can stabilize the voltage level. Data from existing low-voltage (LV) and medium-voltage (MV) networks are used for a case study. The first control method is developed for LV network’s voltage control by means of PV inverter and STATCOM. The second control method is developed for both LV and MV networks’ voltage control, where reactive power control in PV inverters and STATCOMs are used in the LV network and only STATCOMs in the MV network. The control methods follow a hierarchical structure where reactive power compensation using PV inverters are prioritized. The STATCOMs, first in the LV and thereafter in the MV network in the second control method, are used only when the PV inverters are not able to provide or consume enough reactive power. This is beneficial due to the significant reduction in numbers of STATCOMs and their operation. The simulation results indicate that the proposed method is able to control both the over- and undervoltage situations for the test distribution networks. It is also shown that reactive power supply at night by the PV inverters can be an important resource for effective voltage regulation by using the proposed coordinated voltage control method.

  • Sundin, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    International Science Programme (ISP): Annual Report to Sida 20112012Report (Other (popular science, discussion, etc.))
    Abstract [en]

    ISP provides long-term support to Research Groups and Scientific Networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala University is the base of the operation, ISP functions as an international program and host laboratories may be at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms. ISP also handles other research programs, organised by Sida.

    In 2011, ISP provided support to 31 research groups and 14 regional networks. The supported groups are located in ten countries in Asia and Africa; Bangladesh, Burkina Faso, Cambodia, Ethiopia, Kenya, Laos, Mali, Uganda, Zambia, and Zimbabwe. Supported regional networks are coordinated from countries in Asia, Africa and Latin America. Groups and networks together utilized about 19 million SEK.

    A total of 185 PhD students (24% of which were female) were active in ISP-supported research groups and scientific networks in 2011, of which 54% on a sandwich basis. During the year, 19 students graduated on the PhD level, about a third of them participating in sandwich programs. The number Master students was 319, of which 27% were female, and 12% participated in sandwich programs. Of the 96 graduating, only 1 participated on a sandwich basis.

    Regarding dissemination of scientific findings in 2011 it can be noted that 44% of the in total 148 publications in international scientific journals were in high-ranking journals listed with ISI impact factors. In addition, 23 contributions were made in the form of books, chapters, popular publications and technical reports. Furthermore, 183 contributions were made to scientific conferences, 41% at the international, 33% at the regional, and 26% at the national level, and 42 scientific events were arranged.

  • Sundin, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    International Science Programme (ISP): Annual Report to Sida 20102011Report (Other (popular science, discussion, etc.))
    Abstract [en]

    ISP provides long‐term support to Research Groups and Scientific Networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala University is the base of the operation, ISP functions as an international program and host laboratories may be at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms. ISP also handles other research programs, organised by Sida.

    In 2010, 28 Research Groups were supported in 10 African and 4 Asian countries; 5 groups in Kenya, 4 in Sri Lanka, 3 each in Laos and Zimbabwe, 2 each in Bangladesh, Burkina Faso, Cambodia, and Malawi, and 1 each in Ghana, Mali, Nigeria, Senegal and Zambia. In addition, 15 regional Scientific Networks were supported, 12 in Africa, 2 in Asia, and 1 in Latin America.

    A total of 117 PhD students (12% of which were female) were active in ISP‐supported research groups and scientific networks in 2010, of which 57% on a sandwich basis. During the year, 25 students graduated on the PhD level, about half of them participating in sandwich programs. The number Master students were 232, of which 26% were female and 10% participated in sandwich programs.

    Regarding dissemination of scientific findings in 2010 it can be noted that most (66%) of the in total 83 publications in international scientific journals were in high ranking journals listed with ISI impact factors. International publications clearly dominated over publication in regional (15) and national (2) journals. In addition, 18 contributions were made in the form of books, chapters, popular publications andtechnical reports.

  • Eneroth-Ädel, Joel
    et al.
    Bäsén, Sebastian
    Ett fall för fall A - En studie över hantering av schaktmassor vid anläggningsarbeten2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Kulak, Klaudia
    et al.
    Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Med Prot Chem, Inga Marie Nilssons Gata 53, S-20502 Malmo, Sweden..
    Westermark, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Papac-Milicevic, Nikolina
    Med Univ Vienna, Dept Lab Med, Vienna, Austria..
    Renström, Erik
    Lund Univ, Ctr Diabet, Dept Clin Sci Malmo, Malmo, Sweden..
    Blom, Anna M.
    Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Med Prot Chem, Inga Marie Nilssons Gata 53, S-20502 Malmo, Sweden..
    King, Ben C.
    Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Med Prot Chem, Inga Marie Nilssons Gata 53, S-20502 Malmo, Sweden..
    The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation2017In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, no 8, 1522-1533 p.Article in journal (Refereed)
    Abstract [en]

    Aims/hypothesis: Inflammasome activation and subsequent IL-1 beta production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome activation. C4b-binding protein (C4BP), present in serum, binds to IAPP and affects transition of IAPP monomers and oligomers to amyloid fibrils. We therefore hypothesised that C4BP inhibits IAPP-mediated inflammasome activation and IL-1 beta production.

    Methods: Macrophages were exposed to IAPP in the presence or absence of plasma-purified human C4BP, and inflammasome activation was assessed by IL-1 beta secretion as detected by ELISA and reporter cell lines. IAPP fibrillation was assessed by thioflavin T assay. Uptake of IAPP-C4BP complexes and their effects on phagolysosomal stability were assessed by flow cytometry and confocal microscopy. The effect of C4BP regulation of IAPP-mediated inflammasome activation on beta cell function was assessed using a clonal rat beta cell line. Immunohistochemistry was used to examine the association of IAPP amyloid deposits and macrophage infiltration in isolated human and mouse pancreatic islets, and expression of C4BP from isolated human pancreatic islets was assessed by quantitative PCR, immunohistochemistry and western blot.

    Results: C4BP significantly inhibited IAPP-mediated IL-1 beta secretion from primed macrophages at physiological concentrations in a dose-dependent manner. C4BP bound to and was internalised together with IAPP. C4BP did not affect IAPP uptake into phagolysosomal compartments, although it did inhibit its formation into amyloid fibrils. The loss of macrophage phagolysosomal integrity induced by IAPP incubation was inhibited by co-incubation with C4BP. Supernatant fractions from macrophages activated with IAPP inhibited both insulin secretion and viability of clonal beta cells in an IL-1 beta-dependent manner but the presence of C4BP during macrophage IAPP incubation rescued beta cell function and viability. In human and mouse islets, the presence of amyloid deposits correlated with higher numbers of infiltrating macrophages. Isolated human islets expressed and secreted C4BP, which increased with addition of IL-1 beta.

    Conclusions/interpretation: IAPP deposition is associated with inflammatory cell infiltrates in pancreatic islets. C4BP blocks IAPP-induced inflammasome activation by preventing the loss of macrophage phagolysosomal integrity required for NLRP3 activation. The consequence of this is the preservation of beta cell function and viability. C4BP is secreted directly from human pancreatic islets and this increases in response to inflammatory cytokines. We therefore propose that C4BP acts as an extracellular chaperone protein that limits the proinflammatory effects of IAPP.

  • Sundin, Peter
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Abrahamsson, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    van Groningen, Ernst
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Sjöblom, Linnea
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Kristófi, Zsuzsanna
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    International Science Programme: Annual Report for 20082009Report (Other (popular science, discussion, etc.))
    Abstract [en]

    ISP provides long-term support for the development of active and sustainable research environments within these basic sciences in developing countries. The support is directed to research groups and regional networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala Univ. is the base of the operation, ISP functions as a national programme and host laboratories may be located at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms.

    ISP support includes equipment, spare parts consumables, technical services, literature, computer hard- and software, and all costs associated with participating in meetings, exchange visits, training, etc. Besides what has been achieved in terms of development and maintenance of resources, contacts, etc., the outcome of ISP support in 2008 can be summarized by the following figures (assuming that one € equals 10 SEK):

    • 19 PhD graduations per M€ invested.
    • 54 MSc/MPhil graduations per M€ invested.
    • 80 international publications per M€ invested.
    • 27 regional or national publications per M€ invested.
    • 129 conference contributions (> 40% of which international) per M€ invested.
  • Sundin, Peter
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Abrahamsson, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    van Groningen, Ernst
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Sjöblom, Linnea
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Kristófi, Zsuzsanna
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    International Science Programme: Annual Report for 20092010Report (Other (popular science, discussion, etc.))
    Abstract [en]

    ISP provides long-term support for the development of active and sustainable research environments within these basic sciences in developing countries. The support is directed to research groups and regional networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala University is the base of the operation, ISP functions as a national programme and host laboratories may be at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms.

    ISP funding is used for equipment, spare parts, consumables, technical services, literature, computer hard- and software, and costs associated with arranging and participating in meetings, exchange visits, training, etc. Besides what has been achieved in terms of development and maintenance of resources, contacts, etc., the results of ISP support in 2009 can be summarized based on the expenditures. For each MEUR spent (assuming that one EUR equals 10 SEK) the outcome was:

    • 19 PhD graduations,
    • 59 MSc/MPhil graduations,
    • 45 international publications,
    • 58 regional or national publicationst,
    • 113 conference contributions (34% of which international), and
    • 20 conferences/workshops etc. arranged.
  • Holmén, Janne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Mapping Historical Consciousness: Mental Maps of Time and Space among Secondary School Students from Ten Locations around the Baltic and Mediterranean Seas2017In: Journal of Autonomy and Security Studies, ISSN 2489-4265, Vol. 1, no 1, 46-74 p.Article in journal (Refereed)
    Abstract [en]

    The article investigates the temporal and spatial structure of historical consciousness among secondary school students from ten locations around the Baltic and Mediterranean seas. It examines what eras and spaces in history that are important to the students, and discusses how the mental maps of individuals at a certain location are affected by geopolitics and interpretations of historical experiences.

    The results are mainly based upon one open survey question: Write down the name of as many important historical figures as possible within five minutes. Psychological theories of memory are used in order to explain how such simple memory retrieval can be used in studies of historical consciousness. The data from the survey is presented in the form of maps, using techniques of mental mapping developed by geographers,

    The empirical investigation reveals three categories of historical consciousness: national, found in Italy and Morocco, Americanized, found in Sweden, and multipolar, found in Estonia and on Åland and Malta. The article argues that each of the three strands of historical consciousness is linked to specific historical and geopolitical circumstances.

  • Schneider, Robin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    About Supersymmetric Hydrogen2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Stålhammar, Marcus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Warped D-Brane Inflation and Toroidal Compactifications2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    We set out on the ambitious journey to fuse inflation and string theory. We first give a somewhat extensive, yet free from the most complicated details, review of string inflation, discussing concepts as flux compactifications, moduli stabilization, the η-problem and reheating. Then, we consider two specific configurations of type II supergravity; type IIB on T6 with D3-branes and O3-planes, and type IIA on a twisted torus with D6-branes and O6-planes. In both cases, we calculate the scalar potential from the metric ansatzes, and try to uplift it to one of de-Sitter (dS) type. In the IIA-case, we also derive the scalar potential from a super- and Kähler potential, before we search for stable dS-solutions. 

  • Nyåkers, Elin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Den osynliga revoutionen: En fallstudie av kvinnors utövande av medborgarskapet i Rojava2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Blomén, Victoria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Representing group interests: A study on the substantive representation of women and minority groups in the Jordanian House of Representatives2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the world today there is a tendency that women and minority groups are under-represented in political decision-making. In order to come to terms with the under-representation of women and minorities many countries are taking measures to increase the number of women and minority representatives. However,there is an ongoing debate on whether increased number of group representatives lead to increased representation of group interests. The question is if women and minority representatives are more responsive to their respective group’s interests compared to other representatives. In this study, I have conducted asurvey with members of the Jordanian House of Representatives in order to investigate whether women and minority representatives are more responsive to their respective group’s interests compared to other representatives. The survey has been designed to capture representatives’ priorities and attitudes towards certain policy areas and issues. The results from the survey show that women and minority representatives to a certain extent are more responsive to their respective group’s interests compared to other representatives, indicating that an increased number of women and minority representatives would lead to increased representation of women and minority interests. Furthermore,this study finds that female representatives are more responsive to women’s interests when it comes to priorities than when it comes to attitudes, whereas representatives from the Christian minority are more responsive to Christian issues when it comes to attitudes than when it comes to priorities. These results indicate that there are differences between different groups when it comes to the representation of their groups’ interests. Thus, research on one group might not be directly transferable to other groups.

  • Fröbert, Ole
    et al.
    Orebro Univ, Fac Hlth, Dept Cardiol, S-70185 Orebro, Sweden..
    Götberg, Matthias
    Univ Hosp Lund, Dept Cardiol, Lund, Sweden..
    Angerås, Oskar
    Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden..
    Jonasson, Lena
    Univ Hosp Linkoping, Dept Cardiol, Linkoping, Sweden..
    Erlinge, David
    Univ Hosp Lund, Dept Cardiol, Lund, Sweden..
    Engstrom, Thomas
    Univ Copenhagen, Dept Cardiol, Rigshosp, Copenhagen, Denmark..
    Persson, Jonas
    Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, Stockholm, Sweden..
    Jensen, Svend E.
    Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark..
    Omerovic, Elmir
    Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden..
    James, Stefan K
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Lagerqvist, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Nilsson, Johan
    Umea Univ, Dept Publ Hlth & Clin Med, Heart Ctr, Cardiol, Umea, Sweden..
    Kåregren, Amra
    Vesteras Cty Hosp, Dept Cardiol, Vasteras, Sweden..
    Moer, Rasmus
    Feiring Clin, Feiring, Norway..
    Yang, Cao
    Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.;Karolinska Inst, Inst Evironmentol Med, Unit Biostat, Stockholm, Sweden..
    Agus, David B.
    Univ Southern Calif, Lawrence J Ellison Inst Transformat Med, Los Angeles, CA 90089 USA..
    Erglis, Andrejs
    Pauls Stradins Clin Univ Hosp, Latvian Ctr Cardiol, Riga, Latvia..
    Jensen, Lisette O.
    Odense Univ Hosp, Dept Cardiol, Odense, Denmark..
    Jakobsen, Lars
    Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark..
    Christiansen, Evald H.
    Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark..
    Pernow, John
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Cardiol Unit, Stockholm, Sweden..
    Design and rationale for the Influenza vaccination After Myocardial Infarction (IAMI) trial. A registry-based randomized clinical trial2017In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 189, 94-102 p.Article in journal (Refereed)
    Abstract [en]

    Background: Registry studies and case-control studies have demonstrated that the risk of acute myocardial infarction (AMI) is increased following influenza infection. Small randomized trials, underpowered for clinical end points, indicate that future cardiovascular events can be reduced following influenza vaccination in patients with established cardiovascular disease. Influenza vaccination is recommended by international guidelines for patients with cardiovascular disease, but uptake is varying and vaccination is rarely prioritized during hospitalization for AMI.

    Methods/design: The Influenza vaccination After Myocardial Infarction (IAMI) trial is a double-blind, multicenter, prospective, registry-based, randomized, placebo-controlled, clinical trial. A total of 4,400 patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI undergoing coronary angiography will randomly be assigned either to in-hospital influenza vaccination or to placebo. Baseline information is collected from national heart disease registries, and follow-up will be performed using both registries and a structured telephone interview. The primary end point is a composite of time to all cause death, a new AMI, or stent thrombosis at 1 year.

    Implications: The IAMI trial is the largest randomized trial to date to evaluate the effect of in-hospital influenza vaccination on death and cardiovascular outcomes in patients with STEMI or non-STEMI. The trial is expected to provide highly relevant clinical data on the efficacy of influenza vaccine as secondary prevention after AMI.

  • Oftedal, Bergithe E.
    et al.
    Ctr Canc Biol, Dept Genet & Mol Pathol, Adelaide, SA, Australia.;Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway..
    Lundgren, Brita Ardesjö
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Ctr Canc Biol, Dept Genet & Mol Pathol, Adelaide, SA, Australia.
    Hamm, David
    Adapt Biotechnol, 1551 Eastlake Ave E 200, Seattle, WA 98102 USA..
    Gan, Poh-Yi
    Monash Univ, Ctr Inflammatory Dis, Dept Med, Clayton, Vic, Australia..
    Holdsworth, Stephen R.
    Monash Univ, Ctr Inflammatory Dis, Dept Med, Clayton, Vic, Australia..
    Hahn, Christopher N.
    Ctr Canc Biol, Dept Genet & Mol Pathol, Adelaide, SA, Australia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Schreiber, Andreas W.
    SA Pathol, Ctr Canc Biol, ACRF Canc Genom Facil, Adelaide, SA, Australia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Scott, Hamish S.
    Ctr Canc Biol, Dept Genet & Mol Pathol, Adelaide, SA, Australia.;SA Pathol, Ctr Canc Biol, ACRF Canc Genom Facil, Adelaide, SA, Australia.;Univ South Australia, Div Hlth Sci, Sch Pharm & Med Sci, Adelaide, SA, Australia.;Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia.;Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ2017In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 81, 24-33 p.Article in journal (Refereed)
    Abstract [en]

    Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune diseases. T cells develop in the thymus where they undergo positive and negative selection, and the autoimmune regulator (Aire) is central in the establishment of immunological tolerance. Loss of Aire leads to severe multiorgan autoimmune disease with infiltration of autoreactive T cells in affected organs. Here, we have utilized next generation sequencing technology to investigate the T cell receptor repertoire in autoimmunity induced by immunization of mice with a self-antigen, myeloper-oxidase. By investigating the T cell receptor repertoire in peripheral blood, spleen and lumbar lymph nodes from naive and immunized Aire -/- mice and wild type littermates, changes in the usage of V and J genes were evident. Our results identify TCR clonotypes which could be potential targets for immune therapy. Also, Aire -/- autoimmunity is driven by a variety of autoantigens where the autoimmune response is highly polyclonal, and access to the most adjacent immunologically active tissue is required to identify T cell receptor sequences that are potentially unique to the antigen in Aire-/- immunized mice.

  • Public defence: 2017-10-06 10:00 Lindahlssalen, Uppsala
    Junkunlo, Kingkamon
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Regulation of hematopoiesis in the freshwater crayfish, Pacifastacus leniusculus: role of transglutaminase2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The freshwater crayfish, Pacifastacus leniusculus, has been used as a model for studying hematopoiesis or blood cell production or hematopoiesis and immunity. The work of this thesis aims to investigate the impact of factors such as ROS signaling, Ast1, and the PVF/PVR signaling pathway in controlling stem cell behavior during hematopoiesis and specifically the role of the crosslinking enzyme transglutaminase (TGase) in regulation of hematopoiesis.

    The role of ROS in crayfish hematopoiesis was characterized by using the antioxidant named NAC to inhibit ROS production. Low ROS level resulted in a prolonged decrease in hemocyte numbers and a combined injection of LPS and NAC caused a slower rate of new hemocyte production. A low ROS level in cell cultures supplemented with crude Ast1 was found to inhibit cell spreading and a high extracellular TGase activity was detected on the surfaces of APC and HPT cells. We suggest that ROS serves as a prime signal to control proliferation and differentiation of progenitor cells by affecting extracellular TGase activity. We reported an inhibitory effect of Ast1 on TGase enzyme activity and on its crosslinking activity and consequently Ast1 affects the clot formation and thus coagulation by inhibiting the crosslinking activity of the TGase enzyme. Secretion of the clot protein (CP) and the production of CP filament network between spreading cells were observed in HPT cell cultures in vitro. In the presence of CP together with Ast1 in 3D-collagen-I cultures, HPT cells were found to be more elongated and they formed chains of cells throughout the surrounding matrix. In the HPT tissue, CP was located around the HPT cells or around the lobules of HPT, and thus, CP was demonstrated to be a part of ECM and to possibly function together with collagen in generating a suitable environment for HPT progenitor cells. The inhibition of PVF/PVR downstream signaling pathway by Sunitinib malate resulted in a dramatic change of cell morphology and induction of an increase cell surface area during cell culture. The addition of crude Ast1 into the cell cultures in vitro enhanced this effect. Consequently, cell migration was stimulated and a high extracellular TGase activity on HPT cell surface was found after this inhibition. In conclusion, the work in this thesis provides new insight in understanding the role of the extracellular matrix (ECM) and extracellular TGase activity in controlling stem cell activity.

    List of papers
    1. Reactive oxygen species affect transglutaminase activity and regulate hematopoiesis in a crustacean
    Open this publication in new window or tab >>Reactive oxygen species affect transglutaminase activity and regulate hematopoiesis in a crustacean
    2016 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 291, no 34, 17593-17601 p.Article in journal (Refereed) Published
    Abstract [en]

    Reactive oxygen species (ROS) serve as a prime signal in the commitment to hematopoiesis in both mammals and Drosophila. In this study, the potential function of ROS during hematopoiesis in the crayfish Pacifastacus leniusculus was examined. The antioxidant N-acetylcysteine (NAC) was used to decrease ROS in both in vivo and in vitro experiments. An increase in ROS was observed in the anterior proliferation center (APC) after LPS injection. In the absence of NAC, the LPS-induced increase in ROS levels resulted in the rapid restoration of the circulating hemocyte number. In the presence of NAC, a delay in the recovery rate of the hemocyte number was observed. NAC treatment also blocked the spread of APC and other hematopoietic tissue (HPT) cells, maintaining these cells at an undifferentiated stage. Extracellular transglutaminase (TGase) has been shown previously to play a role in maintaining HPT cells in an undifferentiated form. In this study, we show that extracellular TGase activity increased when the ROS level in HPT or APC cells was reduced after NAC treatment. In addition, collagen, a major component of the extracellular matrix and a TGase substrate were co-localized on the HPT cell surface. Taken together, the results of this study show that ROS are involved in crayfish hematopoiesis, in which a low ROS level is required to maintain hematopoietic progenitor cells in the tissue and to reduce hemocyte release. The potential roles of TGase in this process are investigated and discussed.

    Keyword
    extracellular matrix, hematopoiesis, invertebrate, reactive oxygen species (ROS), transglutaminase
    National Category
    Biochemistry and Molecular Biology
    Research subject
    Biology with specialization in Comparative Physiology
    Identifiers
    urn:nbn:se:uu:diva-305568 (URN)10.1074/jbc.M116.741348 (DOI)000383241300011 ()27339892 (PubMedID)
    Funder
    Swedish Research Council, VR 20114797, VR 621-2012-2418
    Available from: 2016-10-19 Created: 2016-10-19 Last updated: 2017-08-22
    2. Role of astakine 1 in regulating transglutaminase activity
    Open this publication in new window or tab >>Role of astakine 1 in regulating transglutaminase activity
    2017 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 76, 77-82 p.Article in journal (Refereed) Published
    Abstract [en]

    Transglutaminase (TGase) has been implicated in maintaining the undifferentiated stage of hematopoietic stem cells (HSC) in the crayfish Pacifastacus leniusculus. TGase activity has been reported to be regulated by astakine1, an essential crayfish cytokine for inducing new hemocyte synthesis in hematopoietic tissue (HPT). Here, the role of astakine1 in TGase activity regulation and clotting protein (CP) cross-linking was characterized. A reduction in TGase activity was observed by the addition of purified astakine1 in vitro for both endogenous crayfish TGase and a commercial purified guinea pig liver TGase. As a result, we observed that astakine1 inhibits TGase enzyme activity and acts as a non-competitive inhibitor for the TGase enzyme. Additionally, the clotting reaction was impaired in the presence of astakine1. A decrease in TGase-mediated crosslinking of ε(γ-glutamyl)-lysine bonds was also observed in the presence of astakine1. In conclusion, this study shows that astakine1 acts as an inhibitor of TGase activity and that it also affects CP cross-linking during crayfish hematopoiesis.

    Place, publisher, year, edition, pages
    Elsevier, 2017
    Keyword
    Astakine1, Clotting protein, Hematopoiesis, Transglutaminase activity
    National Category
    Developmental Biology Other Biological Topics
    Research subject
    Biology with specialization in Comparative Physiology
    Identifiers
    urn:nbn:se:uu:diva-327217 (URN)10.1016/j.dci.2017.05.015 (DOI)28528959 (PubMedID)
    Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-22Bibliographically approved
    3. PDGF/VEGF-related receptor affects transglutaminase activity to control cell migration during crustacean hematopoiesis
    Open this publication in new window or tab >>PDGF/VEGF-related receptor affects transglutaminase activity to control cell migration during crustacean hematopoiesis
    (English)In: ISSN 1547-3287Article in journal (Refereed) In press
    Keyword
    PDGF/VEGF, hematopoiesis, Transglutaminase, Ast1, crayfish
    National Category
    Developmental Biology Cell Biology Immunology
    Research subject
    Biology with specialization in Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-327243 (URN)
    Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-14
    4. Clotting protein - an extracellular matrix (ECM) protein involved in crustacean hematopoiesis
    Open this publication in new window or tab >>Clotting protein - an extracellular matrix (ECM) protein involved in crustacean hematopoiesis
    (English)In: ISSN 0145-305XArticle in journal (Refereed) Submitted
    Keyword
    clotting protein, ECM, hematopoiesis, crustacean
    National Category
    Immunology Cell Biology
    Identifiers
    urn:nbn:se:uu:diva-327248 (URN)
    Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-14
  • Edblom, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Exploration of big data and machine learning in retail2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    During the last couple of years, there has been an immense increase

    in data generation. This new data era has been referred to as the big

    data paradigm. More and more business areas are today realizing the

    power of capturing more data, and by this hope to reveal hidden

    patterns and gain new insights of their business. ICA is one of the

    largest retail business in Sweden, and saw the potential of utilizing

    the big data technologies to take the next step in digitalisation.

    The objective of this thesis is to investigate the role of these

    techniques in combination with machine learning algorithms and

    highlights advantages and possible limitations. Two use cases were

    implemented and tested which reveals possible application areas and

    important aspects to consider.

  • Hultqvist, Greta
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Åberg, Emma
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Camilloni, Carlo
    Univ Cambridge, Dept Chem, Cambridge, England.;Tech Univ Munich, Dept Chem, Munich, Germany.;Tech Univ Munich, Inst Adv Study, Munich, Germany..
    Sundell, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry.
    Andersson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Dogan, Jakob
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden..
    Chi, Celestine N.
    ETH, Lab Phys Chem, Zurich, Switzerland.
    Vendruscolo, Michele
    Univ Cambridge, Dept Chem, Cambridge, England.
    Jemth, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden..
    Emergence and evolution of an interaction between intrinsically disordered proteins2017In: eLIFE, E-ISSN 2050-084X, Vol. 6, e16059Article in journal (Refereed)
    Abstract [en]

    Protein-protein interactions involving intrinsically disordered proteins are important for cellular function and common in all organisms. However, it is not clear how such interactions emerge and evolve on a molecular level. We performed phylogenetic reconstruction, resurrection and biophysical characterization of two interacting disordered protein domains, CID and NCBD. CID appeared after the divergence of protostomes and deuterostomes 450-600 million years ago, while NCBD was present in the protostome/deuterostome ancestor. The most ancient CID/NCBD formed a relatively weak complex (K(d similar to)5 mu M). At the time of the first vertebrate-specific whole genome duplication, the affinity had increased (K-d\similar to 200 nM) and was maintained in further speciation. Experiments together with molecular modeling using NMR chemical shifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-affinity complex which is optimized by modulating direct interactions as well as dynamics, while tolerating several potentially disruptive mutations.

  • Vithanarachchi, Sashiprabha M.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Kovacs, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Borbas, K. Eszter
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Synthesis and photophysical characterization of luminescent lanthanide complexes of nucleotide-functionalized cyclen-and dipicolinate-based ligands2017In: Inorganica Chimica Acta, ISSN 0020-1693, E-ISSN 1873-3255, Vol. 460, 148-158 p.Article in journal (Refereed)
    Abstract [en]

    Luminescent Eu(III)-and Tb(III)-complexes based on functionalized tetraazamacrocycle (cyclen) or dipicolinic acid (dpa) metal binding sites, and carrying 20-or 50-linked uridine moieties were prepared. The light-harvesting antennae were either a coumarin (in the cyclen-based architectures) or the dpa-moiety itself. Antenna excitation resulted in metal-centered emission for all complexes. The presence of the uridine resulted in less intense lanthanide emission compared to non-nucleotide-modified reference compounds. Nd(III)-complexes of cyclen ligands carrying a uridine but without a sensitizing antenna were also synthesized; these are envisioned as energy transfer acceptors to the Eu(III)-complexes. The possibility for Eu-to-Nd energy transfer was probed. The reported complexes are models for oligonucleotide- attached lanthanide probes. (C) 2016 The Author(s). Published by Elsevier B.V.

  • Lind, Thomas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Öhman, Caroline
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Calounova, Gabriela
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Rasmusson, Annica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Andersson, Goran
    Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden..
    Pejler, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala.
    Melhus, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Excessive dietary intake of vitamin A reduces skull bone thickness in mice2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 4, e0176217Article in journal (Refereed)
    Abstract [en]

    Calvarial thinning and skull bone defects have been reported in infants with hypervitaminosis A. These findings have also been described in humans, mice and zebrafish with loss-of-function mutations in the enzyme CYP26B1 that degrades retinoic acid (RA), the active metabolite of vitamin A, indicating that these effects are indeed caused by too high levels of vitamin A and that evolutionary conserved mechanisms are involved. To explore these mechanisms, we have fed young mice excessive doses of vitamin A for one week and then analyzed the skull bones using micro computed tomography, histomorphometry, histology and immunohistochemistry. In addition, we have examined the effect of RA on gene expression in osteoblasts in vitro. Compared to a standard diet, a high dietary intake of vitamin A resulted in a rapid and significant reduction in calvarial bone density and suture diastasis. The bone formation rate was almost halved. There was also increased staining of tartrate resistant acid phosphatase in osteocytes and an increased perilacunar matrix area, indicating osteocytic osteolysis. Consistent with this, RA induced genes associated with bone degradation in osteoblasts in vitro. Moreover, and in contrast to other known bone resorption stimulators, vitamin A induced osteoclastic bone resorption on the endocranial surfaces.

  • Zanzi Bejemark, Karl Martin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ward, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Svenska företags riskbedömning vid utländska investeringar2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The globalized economy has incentivized Swedish companies to invest abroad, especially in emerging markets. When expanding into foreign markets companies must evaluate the adhering risks associated with that particular market. It is paramount that companies account for the country risk in their investment analysis, as any miscalculations could have detrimental effects on a company. Evaluating country risk has proven to be difficult due to the sheer range of aspects that may affect an investment. This study examines the required return on equity of Swedish companies in six different markets, and compares it to three different evaluation models in order to determine what variables constituted any misevaluations. Our analysis indicated that a majority of Swedish companies require too high return on equity compared to the empirical results of the applied model.    

  • Jonsson, Amanda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Karlsson, Lina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Användningen av didaktiska verktyg i matematikundervisningen: Utifrån lågstadielärares perspektiv2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Med denna uppsats var vi intresserade av att ta reda på hur lärare ser på användningen av iPads, datorer, interaktiva skrivtavlor och laborativt material i matematikundervisningen. Vi ville även veta hur ofta och på vilket sätt dessa används samt om det fanns en skillnad i användningen mellan de olika matematiska områdena. Vi valde att göra en enkätstudie där 82 lärare deltog vars svar ligger till grund för vårt arbete. Utifrån denna studie var majoriteten av lärarna positiva till alla didaktiska verktyg men att tillgängligheten och användningen varierade. Interaktiva skrivtavlor fanns tillgänglig hos mindre än hälften av respondenterna medan laborativt material fanns i närmare 100 % av lärarnas klassrum. Datorer och iPads fanns tillgängligt i 70 av respondenternas klassrum och vi fann även att det var en tydlig överrepresentation av iPads. Enkätstudien visade att alla didaktiska verktygen användes för att variera samt individualisera undervisningen. Dock fanns en stor skillnad på lärares användning av iPads, datorer och laborativt material inom matematikundervisningen. iPads och datorer användes för att uppnå ett roligt och lustfyllt lärande medan laborativt material användes för att eleverna skulle få en ökad förståelse för matematik. Med detta arbete vill vi ge en inblick i hur lågstadielärare använder iPads, datorer, interaktiva skrivtavlor samt laborativt material i matematikundervisningen. 

  • Svedberg, Maria
    et al.
    Stockholm University.
    Tännsjö, Torbjörn
    Stockholm University.
    Consequentialism and Free Will: The Conditional Analysis Resuscitated2017In: Harvard Review of Philosophy, ISSN 1062-6239, E-ISSN 2153-9154, Vol. 24, 23-41 p.Article in journal (Refereed)
    Abstract [en]

    Many moral theories incorporate the idea that when an action is wrong, it is wrong because there was something else that the agent could and should have done instead. Most notable among these are consequentialist theories. Relatively little attention has been given to the question of how to understand the meaning of 'could have' in this specific context. However, without an answer to this question, consequentialist theories fail to yield determinate verdicts about the deontic status of actions in real scenarios. It is here argued that a conditional analysis provides the required answer and gives us the most plausible version of consequentialism. Such a conditional analysis has been universally rejected as an analysis of the general meaning of 'could have,' but we show that in the specific context of specifying the meaning of 'could have' in a criterion of right and wrong action, all the stan­dard objections to it fail.

  • Thyrén, Carl
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Siltala, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hur agerar investerare och vad säger teorierna?: - En studie inom aktiemarknaden2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The stock market has a variety of theories that explains how people act and how they base their decisions. The chosen theories in the study are portfolio theory, the efficient market hypothesis (EMH), behavioral finance, behavioral portfolio theory and the adaptive market hypothesis (AMH). The study uses cross-sectional design in the form of a survey to collect quantitative data. The purpose of the paper is to examine how investors act, how much they diversify and how risk averse they are, and then the results are compared with the theories of this thesis.

    The conclusions drawn by the study are that investors who own stocks are the ones that are the most confident, have studied economics, work at banks and those who prefer to buy stocks themselves, and that men tend to be more confident than women. Those who diversify most are younger investors, those who study economics, are shareholders and/or prefer to trade shares themselves, which means that the more relevant knowledge and experience investors have about stocks, the more they diversify. It has not been decided which theory best explains how investors act; most theories are rather used to clarify the results.

  • Terner, Annika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Research in Disability and Habilitation.
    Halilovic, Amra
    Landstinget i Dalarna.
    Predefined Headings as a Base for Intellectual Capital in Swedish Health Care Sector2017In: International Journal of Biology and Biomedicine, ISSN 2367-9085, Vol. 2, 29-35 p.Article in journal (Refereed)
    Abstract [en]

    The health care sector is a knowledge-intensive sector with valuable assets. This stock of knowledge is defined as intellectual capital. Management of intellectual capital in the health care sector faces several challenges; particularly challenging is the lack of integration between the different IT systems and thereby the lack of integrated information. Semantic interoperability allows the right information to be available to the right people at the right time across systems. Structured and standardized predefined headings can be a tool to enable semantic interoperability. The aim of this article is to argue that predefined headings are an expression of knowledge-based healthcare and therefore can be a base for intellectuell capital in the Swedish health care sector. Predefined headings are employed in both electronic health records and in national quality registries. National quality registries are sources of “knowledge of improvement” because they contain data integrated into clinical workflows which, after analysis, can lead to documented evidence-based practice and practicebased evidence. The predefined headings in national quality registries are expressions of important indicators to follow up. The source for the data in national quality registries is data registered in patients’ electronic health records. The predefined headings in electronic health records are expressions of knowledge and experience of what information is necessary to provide good health care. Consequently, predefined headings are expressions of knowledge-based healthcare and can therefore be a base for intellectual capital in the Swedish health care sector.

  • Martinsson, Jonny
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Church and Mission studies.
    Missionär bakom och bortom Järnridån: En kvalitativ studie kring missionsarbetares livsberättelser2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Fredriksson, Emma
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Game Design.
    Combining Shape, Color and Postures for Ambiguous Character Roles2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study explores how character design guidelines can be combined and remixed to create characters whose motivations are ambiguous to the viewer. I investigate some common guidelines that character artists generally follow when designing characters; summarized in a literature review, and then I test various applications of these guidelines through online surveys. I analyze the qualitative data from these surveys to answer the question of how flexible these guidelines are and how far they can be stretched. The study includes the design guidelines for color, shape and posture of the character, to see how each element is added to different kind of characters and how it affects the interpretation when changed. The final part of the study is done with a second online survey collecting qualitative data, including self-created characters built from the guidelines found for the protagonist or the antagonist and the results of the first survey. Two different designs are created and then changed to different versions, where the color scheme, shape or pose is reversed to the other’s role. The results collected from the online survey showed that by just changing color, shape and posture separately; the character is interpreted in new ways – which can be used when creating characters that are supposed to be hard to read. With the change of each separate element and by having the design elements counteract each other, the characters were read as good by about half the participants, while the other half interpreted it as evil. Depending on which design elements that were changed, opinions ranged between characters that are hiding their true nature, to characters that are trying to be good or a character that is supposed to betray the main character. By changing the two factors of color and shape at the same time, however, showed that the character was interpreted as almost strictly either good or evil.

  • Bergquist, Jonatan
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computing Science.
    Blockchain Technology and Smart Contracts: Privacy-preserving Tools2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of this Master's thesis is to explore blockchain technology and smart contracts as a way of building privacy-sensitive applications. The main focus is on a medication plan containing prescriptions, built on a blockchain system of smart contracts. This is an example use case, but the results can be transferred to other ones where sensitive data is being shared and a proof of validity or authentication is needed. First the problem is presented, why medication plans are in need of digitalisation and why blockchain technology is a fitting technology for implementing such an application. Then blockchain technology is explained, since it is a very new and relatively unfamiliar IT construct. Thereafter, a design is proposed for solving the problem. A system of smart contracts was built to prove how such an application can be built, and suggested guidelines for how a blockchain system should be designed to fulfil the requirements that were defined. Finally, a discussion is held regarding the applicability of different blockchain designs to the problem of privacy-handling applications.

  • Gustafsson, Joel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    What have we become?: Organizational identity in the Västerås Police Department2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The organizational change of the Swedish police force has become the victim of massive criticism due to the negative results that have continued since 2015. After the organization experienced a structural change that was something between a merger and an acquisition the operational results have continued to decline. One aspect that has been left out of the discussion has been the organizational identity change of the police.

    Previous research on organizational identity have been very interested in structural organizational changes and have found a vast number of results in different contexts. Identity ambiguity, who are we as an organization, have been present in many cases. Weakened legitimacy claims and changed operational activities have been noticed in many as well.

    This is studied with a qualitative methodology and an inductive research approach. Information from nine interviews with current and former members of the Västerås police department make up the data that is analysed.

    What is discovered is the emergence of frustration as an organizational characteristic. This is experienced through all levels of the organization and has resulted in superfluity and resignations.

  • Svensson, Josefin
    Uppsala University, University Administration, Communications Division.
    Universen 4:2017: En tidning för Uppsala universitets medarbetare2017Collection (editor) (Other (popular science, discussion, etc.))
  • Guo, Yuanyuan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Intercultural Business Communication- A Comparison of China and Sweden2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Markén, Camilla
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Hultqvist, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Improving the internal efficiency at IKEA After Sales focusing on the development of a warehouse management system2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    A warehouse management system shall handle warehousing operations with the aim of gaining control over the company's storage capacity and inventory management. It should support functions such as goods receiving, warehousing, order receiving and orderpicking. In order for a warehouse management system to function optimally, it must be designed for the company's operations.

    The purpose of this thesis work is to analyze the current warehouse management system and associated processes at IKEA After Sales. By analyzing the current situation, the improvement work will result in a development of current system or system replacement. In addition, an implementation plan will be presented for the chosen solution. The systems that have been analyzed are M3 and Astro.

    The research work began with a visit to IKEA After Sales where observations and interviews were conducted. The focus was on mapping how operations work today and where there is potential for a warehouse management system. A list of requirements was then presented to describe what functions a system should contain. The requirement list was discussed with responsible IT-workers for both systems. The survey showed that a lot of work is done manually and is dependent on competent employees.

    The research work resulted in an implementation of untapped functions in the already used system M3. The implementation plan focuses on Warehouse Mobility, inventory function and Wave Picking features with associated routines. The routines for how the business should work was designed to facilitate the workload after implementing the above functions.

  • Ohlin, Hanna
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Exploratory synthesis and characterisation in the Gd-Au-Si-system: A quest for quasicrystals2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The field of crystallography has recently been expanded to include the science of quasicrystals, crystalline structures lacking unit cells and conventional periodicity. This resulted in a paradigm shift in the field, opening up for a whole new branch on the subject of structural chemistry. Despite this, not much is known about the abilities of quasicrystalline and approximant materials. Quasicrystalline approximants in the RE-Au-SM system have previously shown promising results regarding magnetic properties. To explore and discover properties like this is key to further improve the understanding of quasicrystalline materials.

     

    The scope of the project was to explore the Gd-Au-Si system with compositions theoretically calculated to yield possible quasicrystals. In three batches with varying composition ratios, crystals were synthesised, using an arc-melting self-flux method. These were then analysed with powder X-ray diffraction, single crystal X-ray diffraction and electron dispersive spectroscopy (EDS) to characterise the synthesised compounds using diffraction data and composition data respectively.

    The resulting crystals were determined to be of a ternary composition close to what was theoretically calculated. The phase synthesised is yet to be found in any previous work or database, possibly marking it out as a new phase, albeit the structure not being quasicrystalline in nature. Thus, the exploratory study yielded a so for unobserved composition in the Gd-Au-Si system.

  • Wahlbäck, Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Avbrutna offentliga upphandlingar: Ett oförutsebart område inom upphandlingsrätten2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Mot bakgrund av att upphandlingslagstiftningen inte stadgar någon kontraheringsplikt är det upp till den upphandlande myndigheten att välja hur en upphandling avslutas. Ett sätt att avsluta en upphandling är genom att avbryta den. Förutsättningarna för ett avbrytande finns inte uttryckligen reglerat i LOU utan har istället kommit att utvecklas i praxis. I det fall ett avbrytandebeslut blir föremål för överprövning måste den upphandlande myndigheten övertyga rätten om att beslutet vilat på sakliga skäl för att inte bli upphävt. Vad som kan utgöra sakliga skäl råder det i flera fall tveksamheter kring då praxis är spretig och långt från heltäckande. Det i sin tur kan skapa oförutsebarhet eftersom aktörerna inte alltid vet vad de ska förhålla sig till.

    Idag tycks oförutsebarheten inte ha lika starkt samband med vad som kan utgöra sakliga skäl då avgörandena från domstolarna ändå följer en viss röd tråd. Oförutsebarheten är snarare relaterad till osäkerheten kring om det enskilda fallet omfattas av de skäl som domstolarna tidigare har ansett som sakliga. Som exempel på denna problematik kan anges bristande konkurrens som av samtliga instanser har ansetts vara ett sakligt skäl för ett avbrytande. När det återstår en eller ingen anbudsgivare i upphandlingen är utgången i målet oftast självklar. Men om det istället återstår två eller flera anbudsgivare och skälet bristande konkurrens anförs blir utgången i målet emellertid oviss. Att domstolarna i flera fall också tycks ställa olika beviskrav medför svårigheter att förutspå möjligheterna att nå framgång i en överprövningsprocess. Det i sin tur skulle kunna inverka på rättssäkerheten och troligen processbenägenheten.

    Möjligheten att avbryta en upphandling är däremot inte villkorslös. Utöver att avbrytandebeslutet kan bli upphävt kan den upphandlande myndigheten dessutom ådra sig skadeståndsskyldighet motsvarande den uteblivna vinsten. Att en upphandling som avbrutits kan leda till höga skadestånd är ett nytt fenomen till följd av den senaste rättsutvecklingen. Eftersom skadeståndets funktion bland annat är att verka preventivt kan den senaste rättsutvecklingen tänkas få konsekvenser på benägenheten att vilja avbryta respektive överpröva avbrytandebeslut.

    Vidare tycks den lagstadgade motiveringsskyldigheten avseende avbrytandebeslut inte motsvara anbudsgivarnas förväntningar då ett sådant beslut inte tydligt behöver motiveras. Det i sin tur kan ge upphov till onödiga överprövningar. Då det redan finns en bestämmelse om utvidgad motiveringsskyldighet i LOU för vissa typer av beslut, hade det varit önskvärt att även inkludera avbrytandebeslut i den bestämmelsen.

  • Hjorth, Marcus
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Avtalsrättslig efterverkan: Om tolkning och lojalitetsplikt i samverkansavtal2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Engdahl, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Polysemin hos prepositioner: En språkjämförande korpusundersökning2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Denna masteruppsats handlar om prepositioner och ställer frågan om varför denna ordklass är så svår att lära sig. Syftet med studien är att öka förståelsen för några svenska prepositioners distribution och betydelser, särskilt när de används för att uttrycka abstrakta relationer. Under­sökningen utgår alltså ifrån att de abstrakta användningarna av prepositionerna är svårast att använda och förstå, samtidigt som dessa användningar förmodligen är utvecklade metaforiskt ur en mer spatial användning.

    I undersökningen analyserar jag fem vanliga svenska prepositioner, för, med, till, vid, över och fem vanliga engelska prepositioner, after, at, by, for och with. Genom att söka i parallellkorpusen ESPC har jag kunnat se vilka översättningar som används till de olika prepositionerna. Sedan har de abstrakta användningarna analyserats vidare.

    Undersökningen visar att det finns en omfattande polysemi kring prepositionsbruket, preposi­tionerna används i väldigt många betydelser och detta är en av de främsta anledningarna till att ordklassen blir svår att lära sig. Det visar sig även att de abstrakta användningarna med stor sannolikhet utvecklats ur en spatial grundbetydelse. Ofta är detta dock troligen inte till någon större hjälp för en inlärare. Resultatet tyder på att man nog måste acceptera att vissa konstruktioner lärs in utantill.

    Men det tyder även på att det i någon mån går att precisera vilken preposition som gäller vid vissa semantiska betydelser eller roller, t.ex. att ”förmånstagare” markeras med för – man gör något för någon – och att ”ändamål” markeras med till – man använder något till något. Engelskan har for i båda fallen. Också tvåspråkiga lexikons beskrivningar av prepositioner skulle kanske kunna förbättras.

  • Gradin, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    The design of a fast level-1 track trigger for the high luminosity upgrade of ATLAS2016In: PoS - Proceedings of Science, ISSN 1824-8039, E-ISSN 1824-8039, 1-5 p.Article in journal (Other academic)
    Abstract [en]

    The high-luminosity upgrade of the LHC will increase the rate of the proton-proton collisions by approximately a factor of 5 with respect to the initial LHC design. The ATLAS experiment will upgrade consequently, increasing its robustness and selectivity in the expected high radiation environment. In particular, the earliest, hardware based, ATLAS trigger stage ("Level 1") will require higher rejection power, still maintaining efficient selection on many and various physics signatures. The key ingredient is the possibility of extracting tracking information from the brand new full-silicon detector and use it for the decision process. While fascinating, this solution poses a big challenge in the choice of the architecture, due to the reduced latency available at this trigger level (few tens of micro-seconds) and the high expected working rates (order of MHz). In this paper, we review the design possibilities of such a system in a potential new trigger and readout architecture, and present the performance resulting from a detailed simulation of possible hardware-based algorithms, to be implemented in the context of Associative Memories and FPGA technologies, as foreseen by R&D plans on these devices.

  • Agnew, John
    et al.
    Checkel, Jeffrey T.
    Deudney, Daniel
    Mitzen, Jennifer
    Guzzini, Stefano
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government. Danish Institute for International Studies.
    The return of geopolitics in Europe? Social mechanisms and foreign policy identity crises2017In: Cooperation and Conflict, ISSN 0010-8367, E-ISSN 1460-3691, Vol. 52, no 3, 399-422 p.Article in journal (Refereed)
  • Guzzini, Stefano
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government. Danish Institute for International Studies.
    Militarizing politics, essentializing identities: Interpretivist process tracing and the power of geopolitics2017In: Cooperation and Conflict, ISSN 0010-8367, E-ISSN 1460-3691, Vol. 52, no 3, 423-445 p.Article in journal (Refereed)
    Abstract [en]

    This reply to the Symposium on Stefano Guzzini (ed.) The return of geopolitics in Europe?, answers the criticisms by John Agnew, Jeffrey Checkel, Dan Deudney and Jennifer Mitzen. It justifies (1) its specific definition and critique of geopolitics as a theory – and not just a foreign policy strategy; (2) its proposed interpretivist process tracing; (3) the role of mechanisms in constructivist theorizing and foreign policy theory; and (4) its usage of non-Humean causality in the analysis of multiple parallel processes and their interaction. At the same time, it develops the logic of the book’s main mechanism of foreign policy identity crisis reduction.

  • Engwall, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Bertil Näslund2017In: Ekonomisk Debatt, ISSN 0345-2646, Vol. 45, no 1, 65-68 p.Article in journal (Other (popular science, discussion, etc.))
  • Engwall, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Managementindustrin: Missvisande bild av företagsekonomin2017In: Respons, ISSN 2001-2092, no 2, 14-15 p.Article in journal (Other (popular science, discussion, etc.))
  • Engwall, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Moderna företagsledare som scenartister2016In: Organisation & Samhälle, ISSN 2001-9114, E-ISSN 2002-0287, Vol. 3, no 2, 52-55 p.Article in journal (Other (popular science, discussion, etc.))
  • Engwall, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Grävande granskning: medier, politik och marknad2017In: Organisation & Samhälle, ISSN 2001-9114, E-ISSN 2002-0287, Vol. 4, no 1, 52-56 p.Article in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    Mediernas roll som granskande tredje statsmakt är satt under press, samtidigt som den behövs mer än någonsin för all upprätthålla ett demokratiskt fungerande samhälle.

    demokratiskt fungerande

    samhä

    lle.

  • Roberts, Helen M.
    et al.
    UCL Great Ormond Street Institute of Child Health, London, UK.
    Bradby, Hannah
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ingold, Anne
    Hertfordshire, UK.
    Manzotti, Grazia
    UCL Great Ormond Street Institute of Child Health Library, UK.
    Reeves, David
    UCL Great Ormond Street Institute of Child Health Library, UK.
    Liabo, Kristian
    Institute for Health Research, University of Exeter Medical School, UK.
    Moving on: multiple transitions for unaccompanied child migrants leaving care in England and Sweden2017In: International Journal of Social Science Studies, ISSN 2324-8033, E-ISSN 2324-8041, Vol. 5, no 9, 25-34 p.Article in journal (Refereed)
    Abstract [en]

    This paper explores the priorities of young people who arrived in England or Sweden as unaccompanied minors and are leaving the care of the state to transition to adult life. Policy and practice for these young people are themselves in transition in Europe, and we aim to contribute to the slender first person qualitative evidence base for those delivering services. Our methods comprised a scoping review of scholarly and grey literature, and group and individual interviews. Despite a commitment in both countries to listening to the voices of young people, we identified few studies representing the voices of unaccompanied care leavers. In both the literature and our interviews, health in a clinical sense was rarely among their priorities. Their accounts focused on the determinants of health, and in particular housing, education, food and employment. In Sweden, where services are universal rather than targeted, the Health and Social Care Board (Socialstyrelsen) notes the paradox of unaccompanied children being surrounded by adult supporters, none of whom takes overall responsibility for the young person and his/her everyday life. Those we spoke to describe the vital role played by foster carers, health and social care professionals and friends that they could rely on. The young people whose narratives appear in the research literature and those in our own sample are working hard to cope with multiple transitions and to manage health in its widest sense, whether by finding the right place to live or attending to their education or training.

  • Talbot, Christopher
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Mineralogy Petrology and Tectonics.
    Augustin, Nico
    GEOMAR Helmholtz Ctr Ocean Res Kiel, Kiel, Germany..
    Submarine Salt Karst Terrains2016In: AIMS GEOSCIENCES, ISSN 2471-2132, Vol. 2, no 2, 182-200 p.Article in journal (Refereed)
    Abstract [en]

    Karst terrains that develop in bodies of rock salt (taken as mainly of halite, NaCl) are special not only for developing in one of the most soluble of all rocks, but also for developing in one of the weakest rocks. Salt is so weak that many surface-piercing salt diapirs extrude slow fountains of salt that that gravity spread downslope over deserts on land and over sea floors. Salt fountains in the deserts of Iran are usually so dry that they flow at only a few cm/yr but the few rain storms a decade so soak and weaken them that they surge at dm/day for a few days. We illustrate the only case where the rates at which different parts of one of the many tens of subaerial salt karst terrains in Iran flows downslope constrains the rates at which its subaerial salt karst terrains form. Normal seawater is only 10% saturated in NaCl. It should therefore be sufficiently aggressive to erode karst terrains into exposures of salt on the thousands of known submarine salt extrusions that have flowed or are still flowing over the floors of hundreds of submarine basins worldwide. However, we know of no attempt to constrain the processes that form submarine salt karst terrains on any of these of submarine salt extrusions. As on land, many potential submarine karst terrains are cloaked by clastic and pelagic sediments that are often hundreds of m thick. Nevertheless, detailed geophysical and bathymetric surveys have already mapped likely submarine salt karst terrains in at least the Gulf of Mexico, and the Red Sea. New images of these two areas are offered as clear evidence of submarine salt dissolution due to sinking or rising aggressive fluids. We suggest that repeated 3D surveys of distinctive features (+/- fixed seismic reflectors) of such terrains could measure any downslope salt flow and thus offer an exceptional opportunity to constrain the rates at which submarine salt karst terrains develop. Such rates are of interest to all salt tectonicians and the many earth scientists seeking hydrocarbons associated with salt bodies.

  • Agarwal, Jessica
    et al.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    A'Hearn, M. F.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Vincent, J. -B
    Guettler, C.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hoefner, S.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Sierks, H.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Tubiana, C.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Barbieri, C.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservat 3, I-35122 Padua, Italy..
    Lamy, P. L.
    Aix Marseille Univ, Lab Astrophys Marseille, CNRS, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France..
    Rodrigo, R.
    CSIC, Ctr Astrobiol, INTA, European Space Agcy,ESAC, POB 78, E-28691 Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Koschny, D.
    European Space Agcy, Res & Sci Support Dept, NL-2201 Noordwijk, Netherlands..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland..
    Barucci, M. A.
    Univ Paris Diderot, UPMC Univ Paris 06, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Bertaux, J. -L
    Bertini, I.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy..
    Boudreault, S.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Cremonese, G.
    INAF Osservat Astron Padova, Vicolo Osservat 5, I-35122 Padua, Italy..
    Da Deppo, V.
    CNR IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, B.
    Jet Prop Lab, M-S 183-301,4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Debei, S.
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    De Cecco, M.
    Univ Trento, Via Sommarive 9, I-38123 Trento, Italy..
    Deller, J.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Fornasier, S.
    Univ Paris Diderot, UPMC Univ Paris 06, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Fulle, M.
    INAF Osservat Astron Trieste, Via Tiepolo 11, I-34143 Trieste, Italy..
    Gicquel, A.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Groussin, O.
    Aix Marseille Univ, LAM, CNRS, UMR 7326, F-13388 Marseille, France..
    Gutierrez, P. J.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain..
    Hofmann, M.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hviid, S. F.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Ip, W. -H
    Jorda, L.
    Aix Marseille Univ, LAM, CNRS, UMR 7326, F-13388 Marseille, France..
    Keller, H. U.
    TU Braunschweig, Inst Geophys & Extraterr Phys, D-38106 Braunschweig, Germany..
    Knollenberg, J.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kramm, J. -R
    Kuehrt, E.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kueppers, M.
    ESA ESAC, POB 78, E-28691 Villanueva De La Cananda, Spain..
    Lara, L. M.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain..
    Lazzarin, M.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservat 3, I-35122 Padua, Italy..
    Lopez Moreno, J. J.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain..
    Marzari, F.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservat 3, I-35122 Padua, Italy..
    Naletto, G.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy.;CNR IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy.;Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Oklay, N.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Shi, X.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Thomas, N.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Acceleration of individual, decimetre-sized aggregates in the lower coma of comet 67P/Churyumov-Gerasimenko2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S78-S88 p.Article in journal (Refereed)
    Abstract [en]

    We present observations of decimetre-sized, likely ice-containing aggregates ejected from a confined region on the surface of comet 67P/Churyumov-Gerasimenko. The images were obtained with the narrow angle camera of the Optical, Spectroscopic, and Infrared Remote Imaging System on board the Rosetta spacecraft in 2016 January when the comet was at 2 au from the Sun outbound from perihelion. We measure the acceleration of individual aggregates through a 2 h image series. Approximately 50 per cent of the aggregates are accelerated away from the nucleus, and 50 per cent towards it, and likewise towards either horizontal direction. The accelerations are up to one order of magnitude stronger than local gravity, and are most simply explained by the combined effect of gas drag accelerating all aggregates upwards, and the recoil force from asymmetric outgassing, either from rotating aggregates with randomly oriented spin axes and sufficient thermal inertia to shift the temperature maximum away from an aggregate's subsolar region, or from aggregates with variable ice content. At least 10 per cent of the aggregates will escape the gravity field of the nucleus and feed the comet's debris trail, while others may fall back to the surface and contribute to the deposits covering parts of the Northern hemisphere. The rocket force plays a crucial role in pushing these aggregates back towards the surface. Our observations show the future back fall material in the process of ejection, and provide the first direct measurement of the acceleration of aggregates in the innermost coma (<2 km) of a comet, where gas drag is still significant.

  • Feller, C.
    et al.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Fornasier, S.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Hasselmann, P. H.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Barucci, A.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Preusker, F.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Scholten, F.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Jorda, L.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Freder Joliot Curie, F-13388 Marseille, France..
    Pommerol, A.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Jost, B.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Poch, O.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    ElMaary, M. R.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Thomas, N.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Belskaya, I.
    Kharkov Natl Univ, Inst Astron, Sumska Str 35, UA-61022 Kharkov, Ukraine..
    Pajola, M.
    NASA, Ames Res Ctr, Moett Field, CA 94035 USA.;Univ Padua, Ctr Studies & Activ Space CISAS G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Sierks, H.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Barbieri, C.
    Univ Padua, Dept Phys & Astron Galileo Galilei, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Lamy, P. L.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Freder Joliot Curie, F-13388 Marseille, France..
    Koschny, D.
    ESA, European Space Res & Technol Ctr, Res & Sci Support Off, Keplerlaan 1,Postbus 299, NL-2201 AZ Noordwijk, Netherlands..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland..
    Rodrigo, R.
    CSIC, European Space Agcy, ESAC, Ctr Astrobiol,INTA, POB 78, Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Agarwal, J.
    A'Hearn, M.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Bertaux, J. -L
    Bertini, I.
    Univ Padua, Ctr Studies & Activ Space CISAS G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Boudreault, S.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Cremonese, G.
    INAF, Osservatorio Astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Da Deppo, V.
    CNR, IFN, UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, B. J. R.
    Jet Prop Lab, M-S 183-301,4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Debei, S.
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    De Cecco, M.
    Univ Trento, Via Mesiano 77, I-38100 Trento, Italy..
    Deller, J.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Fulle, M.
    INAF, Osservatorio Astron, Via Tiepolo 11, I-34014 Trieste, Italy..
    Giquel, A.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Groussin, O.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Freder Joliot Curie, F-13388 Marseille, France..
    Gutierrez, P. J.
    CSIC, Inst Astrofis Andalucia, C Glorieta Astron S-N, E-18008 Granada, Spain..
    Guettler, C.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hofmann, M.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hviid, S. F.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Keller, H.
    Tech Univ Carolo Wilhelmina Braunschweig, IGEP, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Ip, W. -H
    Knollenberg, J.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kovacs, G.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Kramm, J. -R
    Kuehrt, E.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kuppers, M.
    ESAC, ESA, POB 78, E-28691 Madrid, Spain..
    Lara, M. L.
    Lazzarin, M.
    Leyrat, C.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Moreno, J. J. Lopez
    Tech Univ Carolo Wilhelmina Braunschweig, IGEP, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Marzari, F.
    Masoumzadeh, N.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Mottola, S.
    Deutsches Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Naletto, G.
    Univ Padua, Ctr Studies & Activ Space CISAS G Colombo, Via Venezia 15, I-35131 Padua, Italy.;CNR, IFN, UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy.;Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Perna, D.
    Sorbonne Univ, UPMC Univ Paris 06, Univ Paris Diderot,CNRS, PSL Res Univ,LESIA,Observ Paris,Sorbanne Paris Ci, 5 Pl J Janssen, F-92195 Meudon, France..
    Oklay, N.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Shi, X.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Tubiana, C.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Vincent, J. -B
    Decimetre-scaled spectrophotometric properties of the nucleus of comet 67P/Churyumov-Gerasimenko from OSIRIS observations2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S287-S303 p.Article in journal (Refereed)
    Abstract [en]

    We present the results of the photometric and spectrophotometric properties of the 67P/Churyumov-Gerasimenko nucleus derived with the Optical, Spectroscopic and Infrared Remote Imaging System instrument during the closest fly-by over the comet, which took place on 2015 February 14 at a distance of similar to 6 km from the surface. Several images covering the 0 degrees-33 degrees. phase angle range were acquired, and the spatial resolution achieved was 11 cm pixel(-1). The flown-by region is located on the big lobe of the comet, near the borders of the Ash, Apis and Imhotep regions. Our analysis shows that this region features local heterogeneities at the decimetre scale. We observed difference of reflectance up to 40 per cent between bright spots and sombre regions, and spectral slope variations up to 50 per cent. The spectral reddening effect observed globally on the comet surface by Fornasier et al. (2015) is also observed locally on this region, but with a less steep behaviour. We note that numerous metre-sized boulders, which exhibit a smaller opposition effect, also appear spectrally redder than their surroundings. In this region, we found no evidence linking observed bright spots to exposed water-ice-rich material. We fitted our data set using the Hapke 2008 photometric model. The region overflown is globally as dark as the whole nucleus (geometric albedo of 6.8 per cent) and it has a high porosity value in the uppermost layers (86 per cent). These results of the photometric analysis at a decimetre scale indicate that the photometric properties of the flown-by region are similar to those previously found for the whole nucleus.

  • Tångring, Anton
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Analysing Search Engine Trends related to Antibiotics2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Edberg, Niklas J. T.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Alho, M.
    Aalto Univ, Sch Elect Engn, Dept Radio Sci & Engn, POB 13000, FI-00076 Aalto, Finland..
    André, Mats
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Andrews, David J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Behar, E.
    Swedish Inst Space Phys, Box 812, SE-98128 Kiruna, Sweden..
    Burch, J. L.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78238 USA..
    Carr, C. M.
    Imperial Coll London, Exhibit Rd, London SW7 2AZ, England..
    Cupido, E.
    Imperial Coll London, Exhibit Rd, London SW7 2AZ, England..
    Engelhardt, Ilka. A. D.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Eriksson, Anders I.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Glassmeier, K. -H
    Goetz, C.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Goldstein, R.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78238 USA..
    Henri, P.
    Lab Phys & Chim Environm & Espace, F-45071 Orleans 2, France..
    Johansson, Fredrik L.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Koenders, C.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Mandt, K.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78238 USA.;Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA..
    Moestl, C.
    Austrian Acad Sci, Space Res Inst, Schmiedlstr 6, A-8042 Graz, Austria..
    Nilsson, H.
    Swedish Inst Space Phys, Box 812, SE-98128 Kiruna, Sweden..
    Odelstad, Elias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Richter, I.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Wedlund, C. Simon
    Univ Oslo, Dept Phys, Box 1048 Blindern, N-0316 Oslo, Norway..
    Wieser, G. Stenberg
    Swedish Inst Space Phys, Box 812, SE-98128 Kiruna, Sweden..
    Szego, K.
    Wigner Res Ctr Phys, Konkoly Thege Miklos Ut 29-33, H-1121 Budapest, Hungary..
    Vigren, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Volwerk, M.
    Austrian Acad Sci, Space Res Inst, Schmiedlstr 6, A-8042 Graz, Austria..
    CME impact on comet 67P/Churyumov-Gerasimenko2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S45-S56 p.Article in journal (Refereed)
    Abstract [en]

    We present Rosetta observations from comet 67P/Churyumov-Gerasimenko during the impact of a coronal mass ejection (CME). The CME impacted on 2015 Oct 5-6, when Rosetta was about 800 km from the comet nucleus, and 1.4 au from the Sun. Upon impact, the plasma environment is compressed to the level that solar wind ions, not seen a few days earlier when at 1500 km, now reach Rosetta. In response to the compression, the flux of suprathermal electrons increases by a factor of 5-10 and the background magnetic field strength increases by a factor of similar to 2.5. The plasma density increases by a factor of 10 and reaches 600 cm(-3), due to increased particle impact ionization, charge exchange and the adiabatic compression of the plasma environment. We also observe unprecedentedly large magnetic field spikes at 800 km, reaching above 200 nT, which are interpreted as magnetic flux ropes. We suggest that these could possibly be formed by magnetic reconnection processes in the coma as the magnetic field across the CME changes polarity, or as a consequence of strong shears causing Kelvin-Helmholtz instabilities in the plasma flow. Due to the limited orbit of Rosetta, we are not able to observe if a tail disconnection occurs during the CME impact, which could be expected based on previous remote observations of other CME-comet interactions.