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  • Sun, Song
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada;.
    Weile, Jochen
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Verby, Marta
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Wu, Yingzhou
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Wang, Yang
    Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA;Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA 02115 USA.
    Cote, Atina G.
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Fotiadou, Iosifina
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Kitaygorodsky, Julia
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Vidal, Marc
    Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA;Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA 02115 USA.
    Rine, Jasper
    Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA;Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA.
    Jesina, Pavel
    Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague 12808 2, Czech Republic;Gen Univ Hosp Prague, Prague 12808 2, Czech Republic.
    Kozich, Viktor
    Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague 12808 2, Czech Republic;Gen Univ Hosp Prague, Prague 12808 2, Czech Republic.
    Roth, Frederick P.
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase2020In: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 12, no 1, article id 13Article in journal (Refereed)
    Abstract [en]

    Background For the majority of rare clinical missense variants, pathogenicity status cannot currently be classified. Classical homocystinuria, characterized by elevated homocysteine in plasma and urine, is caused by variants in the cystathionine beta-synthase (CBS) gene, most of which are rare. With early detection, existing therapies are highly effective. Methods Damaging CBS variants can be detected based on their failure to restore growth in yeast cells lacking the yeast ortholog CYS4. This assay has only been applied reactively, after first observing a variant in patients. Using saturation codon-mutagenesis, en masse growth selection, and sequencing, we generated a comprehensive, proactive map of CBS missense variant function. Results Our CBS variant effect map far exceeds the performance of computational predictors of disease variants. Map scores correlated strongly with both disease severity (Spearman's rho = 0.9) and human clinical response to vitamin B-6 (rho = 0.93). Conclusions We demonstrate that highly multiplexed cell-based assays can yield proactive maps of variant function and patient response to therapy, even for rare variants not previously seen in the clinic.

  • Ljungvall, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Rhodin, Annika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Wagner, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Zetterberg, Hedvig
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Åsenlöf, Pernilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    "My life is under control with these medications": an interpretative phenomenological analysis of managing chronic pain with opioids2020In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 21, article id 61Article in journal (Refereed)
    Abstract [en]

    Background: The use of opioids to relieve chronic pain has increased during the last decades, but experiences of chronic opioid therapy (COT) (> 90 days) point at risks and loss of beneficial effects. Still, some patients report benefits from opioid medication, such as being able to stay at work. Guidelines for opioid use in chronic pain do not consider the individual experience of COT, including benefits and risks, making the first person perspective an important scientific component to explore. The aim of this study was to investigate the lived experience of managing chronic pain with opioids in a sample who have severe chronic pain but are able to manage their pain sufficiently to remain at work.

    Methods: We used a qualitative research design: interpretative phenomenological analysis. Ten individuals with chronic pain and opioid therapy were purposively sampled in Swedish tertiary care.

    Results: Three super-ordinate themes emerged from the analyses: Without opioids, the pain becomes the boss; Opioids as a salvation and a curse, and Acknowledgement of the pain and acceptance of opioid therapy enables transition to a novel self. The participants used opioids to regain control over their pain, thus reclaiming their wanted life and self, and sense of control over one's life-world. Using opioids to manage pain was not unproblematic and some of the participants had experienced a downward spiral of escalating pain and uncontrollable opioid use, and stigmatisation.

    Conclusions: All participants emphasised the importance of control, regarding both pain and opioid use. To accomplish this, trust between participants and health care providers was essential for satisfactory treatment. Regardless of the potential sociocultural benefits of staying at work, participants had experiences of balancing positive and negative effects of opioid therapy, similar to what previous qualitative research has found. Measurable improvement of function and quality of life, may justify the long-term use of opioids in some cases. However, monitoring of adverse events should be mandatory. This requires close cooperation and a trusting relationship between the patients and their health care provider.

  • Sibley, Chris G.
    et al.
    Univ Auckland, Auckland, New Zealand.
    Bergh, Robin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Satherley, Nicole
    Univ Auckland, Auckland, New Zealand.
    Osborne, Danny
    Univ Auckland, Auckland, New Zealand.
    Milojev, Petar
    Univ Auckland, Auckland, New Zealand.
    Greaves, Lara M.
    Univ Auckland, Auckland, New Zealand.
    Huang, Yanshu
    Univ Auckland, Auckland, New Zealand.
    Townrow, Carly S.
    Univ Auckland, Auckland, New Zealand.
    Faapoi, Amy
    Univ Auckland, Auckland, New Zealand.
    Yogeeswaran, Kumar
    Univ Canterbury, Christchurch, New Zealand.
    Hawi, Diala
    Doha Inst Grad Studies, Doha, Qatar.
    Duckitt, John
    Univ Auckland, Auckland, New Zealand.
    Profiling authoritarian leaders and followers2019In: TPM - Testing, Psychometrics, Methodology in Applied Psychology, ISSN 1972-6325, Vol. 26, no 3, p. 401-417Article in journal (Refereed)
    Abstract [en]

    Research has long suggested that there may be distinct subpopulations of authoritarian leaders and followers within the broader population. We describe a latent profile analysis of right-wing authoritarianism (RWA) and social dominance orientation (SDO) in a New Zealand national probability sample (N = 18,248) that - for the first time - reliably identifies these two types. Consistent with the positive correlation between SDO and RWA, most people in New Zealand (about 91.2%) expressed comparable levels of RWA and SDO (i.e., moderate-moderate or low-low, but no high-high profile). Two small and distinct subpopulations diverted from this pattern, instead fitting a high-SDO/low-RWA authoritarian leader (1.2%) or low-SDO/high-RWA authoritarian follower (7.6%) profile. Authoritarian leaders tended to show the least concern for human rights, and were least willing to make personal sacrifices for the environment, but tended to support same-sex marriage, while authoritarian followers were particularly opposed to same-sex marriage, and yet highly supportive of human rights. These two profiles represent distinct subpopulations of people within society who are predisposed to seek dominance over others and those predisposed to unquestioningly follow them.

  • Perchiazzi, Gaetano
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hedenstierna laboratory. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Wrigge, Hermann
    Univ Hosp Leipzig, Dept Anesthesiol & Intens Care Med, D-04103 Leipzig, Germany;Bergmannstrost Hosp Halle, Dept Anesthesiol Intens Care & Emergency Med Pain, D-06112 Halle, Germany.
    Acute Respiratory Distress Syndrome (ARDS): Pathophysiological Insights and Lung Imaging2019In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, no 12, article id 2171Article in journal (Other academic)
    Abstract [en]

    Acute respiratory distress syndrome (ARDS) is in the center of the scientific debate both for its complex pathophysiology and for the discussion about the remedies that could contribute to its healing. The intricate interplay of different body systems that characterizes ARDS is mirrored by two main research threads, one centered on the pathophysiological mechanisms of the disease and the other on the new approaches to lung imaging. In this Special Issue of the Journal of Clinical Medicine are presented studies using imaging technologies based on electrical impedance tomography, synchrotron radiation computed tomography and intravital probe-based confocal laser endomicroscopy. The studies on the pathophysiological mechanisms pertain to the evaluation of the biomarkers of the disease and the platelet disfunction during extracorporeal membrane oxygenation. These contributions witness the intensity of ARDS research as many of the key problems of the disease are only in part resolved.

  • Hagström, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Ander, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Cernvall, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Ljótsson, Brjánn
    Division of Psychology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Wiman, Henrik W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    von Essen, Louise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Woodford, Joanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Heeding the psychological concerns of young cancer survivors: A single-arm feasibility trial of CBT and a cognitive behavioral conceptualization of distress2020In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 8, article id e8714Article in journal (Refereed)
    Abstract [en]

    Background

    A subgroup of adolescent and young adult (AYA) survivors of cancer during adolescence report high levels of psychological distress. To date, evidence-based psychological interventions tailored to the cancer-related concerns experienced by this population are lacking. The present study aimed to (1) examine the feasibility and preliminary efficacy of an individualized cognitive behavioral therapy (CBT) intervention for AYA survivors of cancer during adolescence; and (2) identify and conceptualize cancer-related concerns as well as maintaining factors using cognitive-behavioral theory.

    Methods

    A single-arm trial, whereby AYA survivors of cancer during adolescence (aged 17–25 years) were provided individualized face-to-face CBT at a maximum of 15 sessions. Clinical outcomes were assessed at baseline, post-intervention, and three-month follow-up. Intervention uptake, retention, intervention delivery, and reliable change index scores were examined. An embedded qualitative study consisted of two unstructured interviews with each participant pre-intervention. Along with individual behavioral case formulations developed to guide the intervention, interview data was analyzed to identify and conceptualize cancer-related concerns and potential maintaining factors.

    Results

    Ten out of 213 potential participants invited into the study were included, resulting in an overall participation rate of 4.7%. Nine participants completed the intervention, with respectively seven and eight participants completing the post-intervention and three month follow-up assessment. The majority of reported cancer-related concerns and maintaining factors were conceptualized into four themes: social avoidance, fear of emotions and bodily symptoms, imbalance in activity, and worry and rumination.

    Conclusions

    Given significant recruitment difficulties, further research is required to examine barriers to help-seeking in the AYA cancer survivor population. However, the conceptualization of cancer-related concerns and maintaining factors experienced by the population may represent an important first step in the development of psychological support tailored toward AYA cancer survivors’ unique needs.

  • Hulsart Billström, Gry
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Stelzl, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Procter, Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Pujari-Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Insley, Gerard
    GPBio Ltd, Unit 4D, Western Business Pk, Shannnon, Clare, Ireland.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Larsson, Sune
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    In vivo safety assessment of a bio-inspired bone adhesive2020In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 31, no 2, article id 24Article in journal (Refereed)
    Abstract [en]

    A new class of materials, bone adhesives, could revolutionise the treatment of highly fragmented fractures. We present the first biological safety investigation of a bio-inspired bone adhesive. The formulation was based upon a modified calcium phosphate cement that included the amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable calcium phosphate cements. Four adhesive groups with the active substance (phosphoserine) and two control groups without phosphoserine were selected for in vitro and in vivo biocompatibility testing. The test groups were subject for cell viability assay and subcutaneous implantation in rats that was followed by gene expression analysis and histology assessment after 6 and 12 weeks. All adhesive groups supported the same rate of cell proliferation compared to the alpha-TCP control and had viability between 45-64% when compared to cell control. There was no evidence of an increased immune response or ectopic bone formation in vivo. To conclude, this bio-inspired bone adhesive has been proven to be safe, in the present study, without any harmful effects on the surrounding soft tissue. 

  • Melkersson, Kristina
    et al.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Wernroth, Lisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Type 1 diabetes mellitus and the risk for schizophrenia or schizoaffective disorder: a Swedish nationwide register-based cohort study2019In: Neuro - endocrinology letters, ISSN 0172-780X, Vol. 40, no 3, p. 125-134Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Type 1 diabetes mellitus (T1DM), resulting from an immune-associated destruction of insulin-secreting pancreatic beta-cells, has been reported in a few earlier studies to be inversely associated with schizophrenia, but not with schizophrenia-like psychoses. The aim of this study was to verify this finding by carrying out a Swedish register study.

    METHODS: Data from the Total Population- and Medical Birth-Registers were used to create a cohort of all individuals born in Sweden 1987-2004. The cohort individuals were linked with the Inpatient- and Outpatient-Registers and followed from birth to 2017 to identify onset of T1DM, schizophrenia and schizoaffective disorder. Cox proportional hazard regression models were used to assess the association between T1DM and risk of developing schizophrenia or schizoaffective disorder during a follow-up from age 13.

    RESULTS: The study population included 1 745 977 individuals and the length of follow-up was maximally 18.0 (median 9.7) years. During the follow-up, 1 280 individuals developed schizophrenia and 649 individuals schizoaffective disorder. The risk of developing schizophrenia was significantly lower among individuals with, than among individuals without, a diagnosis of T1DM, whereas the risk of developing schizoaffective disorder did not differ among individuals with or without a T1DM diagnosis [adjusted hazard ratio (95% confidence interval); schizophrenia: 0.29 (0.09-0.91), p=0.0338, schizoaffective disorder: 1.50 (0.71-3.16), p=0.29091].

    CONCLUSIONS: This study, in line with previous studies, shows that a diagnosis of T1DM is associated with a decreased risk of schizophrenia. This finding of an inverse association between T1DM and schizophrenia may bring an interesting piece, related to autoimmunity, into the schizophrenia-aetiology puzzle.

  • Söderbäck, Hanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The "warming war": Securitizing climate change at the UN Security Council2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of this study was to explore the discursive strategies involved when representatives of small island developing States (SIDS) attempt to securitize climate change in the Security Council, in order to understand which, if any, discursive strategies are successful, and if the securitizing attempt itself is successful. The theoretical framework is based on securitization theory as developed by the Copenhagen school, and the material for the analysis is made up of four meeting records from meetings of the Security Council, ranging from 2007 until 2019. The method chosen to carry out the analysis was discourse analysis. The study found three discursive strategies that were used by the representatives of SIDS; "climate change as a conventional threat"; "climate change and moral responsibility"; and "climate change as an encompassing threat". The study ultimately found that the securitizing attempt was partially successful. 

  • Christensson, Victoria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Civil society and peace - a holy relationship?: A case study on the role of faith-based organizations in peacebuilding and their promotion of human rights in Colombia.2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This master thesis deals with civil society peacebuilding and human rights, aiming to explore the relationship between these perspectives. In more detail, the peacebuilding functions of the Colombian faith-based network of DiPaz are examined in a context where the Government of Colombia and the FARC guerilla have signed a peace agreement and officially entered a postconflict phase, and to realize the examination the comprehensive framework of Thania Paffenholz and Christoph Spurk (2010) is used. Moreover, a human rights perspective on the functions is applied in order to examine the possibilities of using the agendas of peacebuilding and human rights simultaneously with that purpose of working towards a sustainable peace in Colombia. The conclusion is that the framework is useful when examining the relationship between civil society and peacebuilding, and that the peacebuilding functions of DiPaz are of relevance. Finally, a human rights agenda is frequently used simultaneously by DiPaz to promote the respect of human rights and sustainable peace.

  • Altai, Mohamed
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Garousi, Javad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Rinne, Sara S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Schulga, Alexey
    Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia.
    Deyev, Sergey
    Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia;Natl Res Tomsk Polytech Univ, Tomsk, Russia;Sechenov Univ, Ctr BioMed Engn, Moscow, Russia.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Natl Res Tomsk Polytech Univ, Tomsk, Russia.
    On the prevention of kidney uptake of radiolabeled DARPins2020In: EJNMMI Research, ISSN 2191-219X, E-ISSN 2191-219X, Vol. 10, article id 7Article in journal (Refereed)
    Abstract [en]

    Background: Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14-18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPins labeled with residualizing labels is a limitation for targeted radionuclide therapy. A better understanding of the mechanisms behind the kidney uptake of DARPins could aid the development of strategies to reduce it. In this study, we have investigated whether the renal uptake of [Tc-99m]Tc(CO)(3)-G3 DARPin could be reduced by administration of compounds that act on various parts of the reabsorption system in the kidney.

    Results: Co-injection of lysine or Gelofusine was not effective for the reduction of kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Administration of sodium maleate before the injection of [Tc-99m]Tc(CO)(3)-G3 reduced the kidney-associated activity by 60.4 +/- 10.3%, while administration of fructose reduced it by 46.9 +/- 7.6% compared with the control. The decrease in the kidney uptake provided by sodium maleate was also observed for [Tc-99m]Tc(CO)(3)-9_29 DARPin. Preinjection of colchicine, probenecid, mannitol, or furosemide had no effect on the kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Kidney autoradiography showed mainly cortical accumulation of activity for all studied groups.

    Conclusion: Common clinical strategies were not effective for the reduction of kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Both fructose and maleate lower the cellular ATP level in the proximal tubule cells and their reduction of the kidney reuptake indicates the involvement of an ATP-driven uptake mechanism. The decrease provided by maleate for both G3 and 9_29 DARPins indicates that their uptake proceeds through a mechanism independent of DARPin structure and binding site composition.

  • Ren, Zhengyong
    et al.
    Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Peoples R China.
    Kalscheuer, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Uncertainty and Resolution Analysis of 2D and 3D Inversion Models Computed from Geophysical Electromagnetic Data2020In: Surveys in geophysics, ISSN 0169-3298, E-ISSN 1573-0956, Vol. 41, no 1, p. 47-112Article in journal (Refereed)
    Abstract [en]

    A meaningful solution to an inversion problem should be composed of the preferred inversion model and its uncertainty and resolution estimates. The model uncertainty estimate describes an equivalent model domain in which each model generates responses which fit the observed data to within a threshold value. The model resolution matrix measures to what extent the unknown true solution maps into the preferred solution. However, most current geophysical electromagnetic (also gravity, magnetic and seismic) inversion studies only offer the preferred inversion model and ignore model uncertainty and resolution estimates, which makes the reliability of the preferred inversion model questionable. This may be caused by the fact that the computation and analysis of an inversion model depend on multiple factors, such as the misfit or objective function, the accuracy of the forward solvers, data coverage and noise, values of trade-off parameters, the initial model, the reference model and the model constraints. Depending on the particular method selected, large computational costs ensue. In this review, we first try to cover linearised model analysis tools such as the sensitivity matrix, the model resolution matrix and the model covariance matrix also providing a partially nonlinear description of the equivalent model domain based on pseudo-hyperellipsoids. Linearised model analysis tools can offer quantitative measures. In particular, the model resolution and covariance matrices measure how far the preferred inversion model is from the true model and how uncertainty in the measurements maps into model uncertainty. We also cover nonlinear model analysis tools including changes to the preferred inversion model (nonlinear sensitivity tests), modifications of the data set (using bootstrap re-sampling and generalised cross-validation), modifications of data uncertainty, variations of model constraints (including changes to the trade-off parameter, reference model and matrix regularisation operator), the edgehog method, most-squares inversion and global searching algorithms. These nonlinear model analysis tools try to explore larger parts of the model domain than linearised model analysis and, hence, may assemble a more comprehensive equivalent model domain. Then, to overcome the bottleneck of computational cost in model analysis, we present several practical algorithms to accelerate the computation. Here, we emphasise linearised model analysis, as efficient computation of nonlinear model uncertainty and resolution estimates is mainly determined by fast forward and inversion solvers. In the last part of our review, we present applications of model analysis to models computed from individual and joint inversions of electromagnetic data; we also describe optimal survey design and inversion grid design as important applications of model analysis. The currently available model uncertainty and resolution analyses are mainly for 1D and 2D problems due to the limitations in computational cost. With significant enhancements of computing power, 3D model analyses are expected to be increasingly used and to help analyse and establish confidence in 3D inversion models.

  • Ahlberg, Per
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Follow the footprints and mind the gaps: a new look at the origin of tetrapods2019In: Earth and environmental science transactions of the Royal Society of Edinburgh, ISSN 1755-6910, E-ISSN 1755-6929, Vol. 109, no 1-2, p. 115-137Article in journal (Refereed)
    Abstract [en]

    The hypothesis that tetrapods evolved from elpistostegids during the Frasnian, in a predominantly aquatic context, has been challenged by the discovery of Middle Devonian tetrapod trackways predating the earliest body fossils of both elpistostegids and tetrapods. Here I present a new hypothesis based on an overview of the trace fossil and body fossil evidence. The trace fossils demonstrate that tetrapods were capable of performing subaerial lateral sequence walks before the end of the Middle Devonian. The derived morphological characters of elpistostegids and Devonian tetrapods are related to substrate locomotion, weight support and aerial vision, and thus to terrestrial competence, but the retention of lateral-line canals, gills and fin rays shows that they remained closely tied to the water. Elpistostegids and tetrapods both evolved no later than the beginning of the Middle Devonian. The earliest tetrapod records come from inland river basins, sabkha plains and ephemeral coastal lakes that preserve few, if any, body fossils; contemporary elpistostegids occur in deltas and the lower reaches of permanent rivers where body fossils are preserved. During the Frasnian, elpistostegids disappear and these riverine-deltaic environments are colonised by tetrapods. This replacement has, in the past, been misinterpreted as the origin of tetrapods.

  • Södersten, Jan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies.
    Why the Norwegian shareholder income tax is neutral2020In: International Tax and Public Finance, ISSN 0927-5940, E-ISSN 1573-6970, Vol. 27, no 1, p. 32-37Article in journal (Refereed)
    Abstract [en]

    This note extends the work by Sorensen (Int Tax Public Finance 12:777-801, 2005) and others by demonstrating why the Norwegian Shareholder Income Tax may be neutral between the two sources of equity funds, i.e., new share issues and retained earnings, despite the fact that the retention of earnings to finance new investment does not add to the tax benefits. The analysis crucially relies on the assumption that the deduction for the imputed rate of return is capitalized into the market prices of corporate shares. Absent capitalization, the shareholder tax is rather likely to leave the distortions caused by the double taxation of corporate source income unaffected.

  • Svanberg, Ingvar
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Russian and Eurasian Studies.
    Berggren, Åsa
    Swedish Univ Agr Sci, Dept Ecol, Box 7070, SE-75007 Uppsala, Sweden.
    Ant schnapps for health and pleasure: the use of Formica rufa L. (Hymenoptera: Formicidae) to flavour aquavit2019In: Journal of Ethnobiology and Ethnomedicine, ISSN 1746-4269, E-ISSN 1746-4269, Vol. 15, article id 68Article in journal (Refereed)
    Abstract [en]

    Background: The relationship between humans and insects goes long back and is important. Insects provide a multitude of ecosystem services for humans, e g. by pollinating crops and decomposing matter. Our current knowledge about the cultural ecosystem services that insects provide is limited and not much examined.

    Method: Scattered ethnographical descriptions and folklore records from pre-modern Sweden and other Scandinavian countries give us insights into local knowledge and use of insects among the peasantry in various parts of the country. These data have been analysed and critically reviewed. Source pluralism has been used as a method.

    Results: The mound-building red wood ant, Formica rufa L., is one of the species that were used in Sweden for their healing properties. It was a widespread belief that the formic acid could be used to cure various diseases, especially gout and rheumatism. Both anthills and the ants themselves were used for that purpose. It was also common to flavour distilled liquor (brannvin) with ants; a remedy used for medicinal purposes. However, already in the eighteenth century, this was also used as schnapps. The cultural services provided by this species stretches throughout history and still exists today.

    Conclusion: While the use of ants in medicine has vanished, the custom of making homemade ant flavoured alcoholic beverage survives in Sweden. Nowadays it is a hobby among people who flavour their own aquavit. It is appreciated as a tasty and interesting drink.

  • Niaudet, Colin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Petkova, Milena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Jung, Bongnam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Lu, S.
    Max Planck Inst Heart & Lung Res, Dept Pharmacol, D-61231 Bad Nauheim, Germany.
    Laviña, Bàrbara
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Offermanns, S.
    Max Planck Inst Heart & Lung Res, Dept Pharmacol, D-61231 Bad Nauheim, Germany.
    Brakebusch, C.
    Univ Copenhagen, Biotech Res & Innovat Ctr, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark.
    Betsholtz, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Adgrf5 contributes to patterning of the endothelial deep layer in retina2019In: Angiogenesis, ISSN 0969-6970, E-ISSN 1573-7209, Vol. 22, no 4, p. 491-505Article in journal (Refereed)
    Abstract [en]

    Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular pathways preventing subretinal vascularization remain largely unknown. In most murine models of RAP, pathological neo-vascularization occurs concomitantly with the development of the retinal vasculature. Here, we demonstrate that disturbing the sequence of morphogenetic events that shape the three-layered retinal vascular network leads to subretinal vascularization. Sprouts emerging from the perivenous region after the first postnatal week extended toward the retinal space where they merged into the deep layer. The small GTPase Rac1 was required for the formation of these vascular extensions and the vascular inner plexus is formed coaxially to the overarching veins. The adhesion receptor Adgrf5 was highly expressed in the endothelium of the central nervous system, where it regulates blood-brain barrier formation. The vascular superficial plexus of Adgrf5 mutant mouse retinae exhibited an increased vascular density in the perivenous areas with increased projections toward the inner plexus where they subsequently created hyper-dense endothelial cells (EC) clusters. Disturbing the perivenous pool of EC thus significantly altered the inner plexus formation. These abnormalities culminated in transient vascular protrusions in the inner retinal space. Taken together, these results reveal a previously unobserved vascular morphogenetic defect in Adgrf5 knockout mice, implicating a role for ADGRF5 in the initiation of subretinal vascularization. Our findings also illustrate how vein-derived EC shape the inner retinal layer formation and could control the appearance of angiomatous malformations.

  • Rider, Sharon
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Logic and Metaphysics.
    Modal Power, Self-Conscious Science, and the Critique of Epistemic Paternalism, or How to Change your Mind: An Interview with Steve Fuller2019In: DISPUTATIO-PHILOSOPHICAL RESEARCH BULLETIN, ISSN 2254-0601, Vol. 8, no 11, p. 597-615Article in journal (Other academic)
    Abstract [en]

    This interview with Steve Fuller was conducted by e-mail between 3 September and 31 October, 2019, Professor Steve Fuller was sent six detailed, written questions regarding a number of his fundamental concerns as these have been articulated throughout his work. The broad themes covered have to do, inter alia, with his views on philosophy as a discipline, the conditions of scientific progress, the role of traditions in human thinking, and the implications of his position on these and other issues for the future of higher education. The interview consists of the questions together with his written responses.  A list of references to published works relevant to Professor Fuller’s answers in the interview is appended.

  • Huang, Hongyun
    et al.
    Peoples Liberat Army Gen Hosp, Inst Neurorestoratol, Med Ctr 3, 69 Yongding Rd, Beijing 100039, Peoples R China;Hongtianji Neurosci Acad, Lingxiu Bldg,1 Gucheng St, Beijing, Peoples R China.
    Young, Wise
    Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, Piscataway, NJ USA.
    Skaper, Stephen
    Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, Italy.
    Chen, Lin
    Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Beijing, Peoples R China.
    Moviglia, Gustavo
    Maimonides Univ, Ctr Res & Engineer Tissues & Cellular Therapy, Buenos Aires, DF, Argentina.
    Saberi, Hooshang
    Univ Tehran Med Sci, Brain & Spinal Injury Res Ctr, Dept Neurosurg, Tehran, Iran.
    Al-Zoubi, Ziad
    Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan.
    Sharma, Hari Shanker
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Muresanu, Dafin
    Univ Med & Pharm, Dept Neurosci Iuliu Hatieganu, Cluj Napoca, Romania.
    Sharma, Alok
    LTMG Hosp, LTM Med Coll, Dept Neurosurg, Mumbai, Maharashtra, India.
    El Masry, Wagih
    Robert Jones & Agnes Hunt Orthopaed Hosp, Spinal Injuries Unit, Oswestry, Shrops, England.
    Feng, Shiqing
    Tianjin Med Univ, Dept Orthopaed, Gen Hosp, 154 Anshan Rd, Tianjin 300052, Peoples R China.
    Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)2020In: JOURNAL OF ORTHOPAEDIC TRANSLATION, ISSN 2214-031X, Vol. 20, p. 14-24Article, review/survey (Refereed)
    Abstract [en]

    Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, "Clinical Therapeutic Guidelines of Neurorestoration for Spinal Cord Injury (China Version 2016)" was first proposed in 2016 by the Chinese Association of Neurorestoratology (CANR). Given the rapid advances in this field in recent years, the International Association of Neurorestoratology (IANR) and CANR formed and approved the "Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)". These guidelines mainly introduce restoring damaged neurological structure and functions by varying neurorestorative strategies in acute, subacute, and chronic phases of SCI. These guidelines can provide a neurorestorative therapeutic standard or reference for clinicians and researchers in clinical practice to maximally restore functions of patients with SCI and improve their quality of life. The translational potential of this article: This guideline provided comprehensive management strategies for SCI, which contains the evaluation and diagnosis, pre-hospital first aid, treatments, rehabilitation training, and complications management. Nowadays, amounts of neurorestorative strategies have been demonstrated to be benefit in promoting the functional recovery and improving the quality of life for SCI patients by clinical trials. Also, the positive results of preclinical research provided lots of new neurorestorative strategies for SCI treatment. These promising neurorestorative strategies are worthy of translation in the future and can promote the advancement of SCI treatments.

  • Martinez-Sancho, Elisabet
    et al.
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    Slamova, Lenka
    Morganti, Sandro
    Grefen, Claudio
    Philipps Univ Marburg, Dept Biol, Karl von Frisch Str 8, D-35043 Marburg, Germany.
    Carvalho, Barbara
    Natl Museum Nat Sci MNCN CSIC, Dept Biogeog & Global Change, Serrano 115 Dpdo, Madrid 28006, Spain.
    Dauphin, Benjamin
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    Rellstab, Christian
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    Gugerli, Felix
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    Opgenoorth, Lars
    Philipps Univ Marburg, Dept Biol, Karl von Frisch Str 8, D-35043 Marburg, Germany.
    Heer, Katrin
    Philipps Univ Marburg, Dept Biol, Karl von Frisch Str 8, D-35043 Marburg, Germany.
    Knutzen, Florian
    Bavarian Off Forest Seeding & Planting ASP, Forstamtspl 1, D-83317 Teisendorf, Germany.
    von Arx, Georg
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    Valladares, Fernando
    Natl Museum Nat Sci MNCN CSIC, Dept Biogeog & Global Change, Serrano 115 Dpdo, Madrid 28006, Spain.
    Cavers, Stephen
    Ctr Ecol & Hydrol NERC, Edinburgh EH26 0QB, Midlothian, Scotland.
    Fady, Bruno
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Alia, Ricardo
    Ctr Invest Forestal INIA CIFOR, Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctra Coruna Km 7-5, Madrid 28040, Spain.
    Aravanopoulos, Filippos
    Aristotle Univ Thessaloniki, Sch Forestry & Nat Environm, Lab Forest Genet & Tree Breeding, Thessaloniki 54124, Greece.
    Avanzi, Camilla
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Bagnoli, Francesca
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Barbas, Evangelos
    Aristotle Univ Thessaloniki, Sch Forestry & Nat Environm, Lab Forest Genet & Tree Breeding, Thessaloniki 54124, Greece.
    Bastien, Catherine
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Benavides, Raquel
    Natl Museum Nat Sci MNCN CSIC, Dept Biogeog & Global Change, Serrano 115 Dpdo, Madrid 28006, Spain.
    Bernier, Frederic
    INRA, Route Arcachon 69, F-33610 Cestas, France.
    Bodineau, Guillaume
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Bastias, Cristina C.
    Natl Museum Nat Sci MNCN CSIC, Dept Biogeog & Global Change, Serrano 115 Dpdo, Madrid 28006, Spain.
    Charpentier, Jean-Paul
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Climent, Jose M.
    Ctr Invest Forestal INIA CIFOR, Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctra Coruna Km 7-5, Madrid 28040, Spain.
    Correard, Marianne
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Courdier, Florence
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Danusevicius, Darius
    Vytautas Magnus Univ, Studentu St 11, LT-53361 Akademija, Lithuania.
    Farsakoglou, Anna-Maria
    Aristotle Univ Thessaloniki, Sch Forestry & Nat Environm, Lab Forest Genet & Tree Breeding, Thessaloniki 54124, Greece.
    Garcia del Barrio, Jose M.
    Ctr Invest Forestal INIA CIFOR, Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctra Coruna Km 7-5, Madrid 28040, Spain.
    Gilg, Olivier
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Gonzalez-Martinez, Santiago C.
    INRA, Route Arcachon 69, F-33610 Cestas, France.
    Gray, Alan
    Ctr Ecol & Hydrol NERC, Edinburgh EH26 0QB, Midlothian, Scotland.
    Hartleitner, Christoph
    LIECO GmbH & Co KG, Forstgarten 1, A-8775 Kalwang, Austria.
    Hurel, Agathe
    INRA, Route Arcachon 69, F-33610 Cestas, France.
    Jouineau, Arnaud
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Kaerkkaeinen, Katri
    Univ Oulu, Nat Resources Inst Finland, Paavo Havaksen Tie 3, Oulu 90014, Finland.
    Kujala, Sonja T.
    Univ Oulu, Nat Resources Inst Finland, Paavo Havaksen Tie 3, Oulu 90014, Finland.
    Labriola, Mariaceleste
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Lascoux, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Lefebvre, Marlene
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Lejeune, Vincent
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Liesebach, Mirko
    Thunen Inst Forest Genet, Sieker Landstr 2, D-22927 Grosshansdorf, Germany.
    Malliarou, Ermioni
    Aristotle Univ Thessaloniki, Sch Forestry & Nat Environm, Lab Forest Genet & Tree Breeding, Thessaloniki 54124, Greece.
    Mariotte, Nicolas
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Matesanz, Silvia
    Univ Rey Juan Carlos, Area Biodiversidad & Conservac, Calle Tulipan S-N, Mostoles 28933, Spain.
    Myking, Tor
    Norwegian Inst Bioecon Res NIBIO, Div Forestry & Forest Resources, POB 115, N-1431 As, Norway.
    Notivol, Eduardo
    Ctr Invest & Tecnol Agroalimentaria Aragon, Unidad Recursos Forest CITA, Avda Montanana 930, Zaragoza 50059, Spain.
    Pakull, Birte
    Thunen Inst Forest Genet, Sieker Landstr 2, D-22927 Grosshansdorf, Germany.
    Piotti, Andrea
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Pringarbe, Mehdi
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Pyhaejaervi, Tanja
    Univ Oulu, Pentti Kaiteran Katu 1, Oulu 90014, Finland.
    Raffin, Annie
    INRA, Route Arcachon 69, F-33610 Cestas, France.
    Ramirez-Valiente, Jose A.
    Ctr Invest Forestal INIA CIFOR, Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctra Coruna Km 7-5, Madrid 28040, Spain.
    Ramskogler, Kurt
    LIECO GmbH & Co KG, Forstgarten 1, A-8775 Kalwang, Austria.
    Robledo-Arnuncio, Juan J.
    Ctr Invest Forestal INIA CIFOR, Inst Nacl Invest & Tecnol Agr & Alimentaria, Ctra Coruna Km 7-5, Madrid 28040, Spain.
    Savolainen, Outi
    Univ Oulu, Pentti Kaiteran Katu 1, Oulu 90014, Finland.
    Schueler, Silvio
    Austrian Res Ctr Forests BFW, Seckendorff Gudent Weg 8, A-1131 Vienna, Austria.
    Semerikov, Vladimir
    RAS, Ural Branch, Inst Plant & Anim Ecol, 8 Marta St 202, Ekaterinburg 620144, Russia.
    Spanu, Ilaria
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Thevenet, Jean
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Mette Tollefsrud, Mari
    Univ Rey Juan Carlos, Area Biodiversidad & Conservac, Calle Tulipan S-N, Mostoles 28933, Spain.
    Turion, Norbert
    INRA, Domaine St Paul, Site Agroparc, F-84914 Avignon, France.
    Veisse, Dominique
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Vendramin, Giovanni Giuseppe
    Natl Res Council CNR, Inst Biosci & BioResources, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy.
    Villar, Marc
    INRA, Ave Pomme Pin 2163, F-45075 Orleans, France.
    Westin, Johan
    Skogforsk, Tomterna 1, S-91821 Savar, Sweden.
    Fonti, Patrick
    Swiss Fed Inst Forest Snow & Landscape Res WSL, Zurcherstr 111, CH-8903 Birmensdorf, Switzerland.
    The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe2020In: Scientific Data, E-ISSN 2052-4463, Vol. 7, article id 1Article in journal (Refereed)
    Abstract [en]

    The dataset presented here was collected by the GenTree project (EU-Horizon 2020), which aims to improve the use of forest genetic resources across Europe by better understanding how trees adapt to their local environment. This dataset of individual tree-core characteristics including ring-width series and whole-core wood density was collected for seven ecologically and economically important European tree species: silver birch (Betula pendula), European beech (Fagus sylvatica), Norway spruce (Picea abies), European black poplar (Populus nigra), maritime pine (Pinus pinaster), Scots pine (Pinus sylvestris), and sessile oak (Quercus petraea). Tree-ring width measurements were obtained from 3600 trees in 142 populations and whole-core wood density was measured for 3098 trees in 125 populations. This dataset covers most of the geographical and climatic range occupied by the selected species. The potential use of it will be highly valuable for assessing ecological and evolutionary responses to environmental conditions as well as for model development and parameterization, to predict adaptability under climate change scenarios.

  • Sakr, Mahmoud A.
    et al.
    AUC, Grad Program Nanotechnol, New Cairo 11835, Egypt;AUC, Dept Mech Engn, New Cairo 11835, Egypt.
    Elgammal, Karim
    KTH Royal Inst Technol, Sch Engn Sci, Dept Appl Phys, Electrum 229, SE-16440 Kista, Sweden;KTH Royal Inst Technol, Swedish E Sci Res Ctr SeRC, SE-10044 Stockholm, Sweden.
    Delin, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Sch Engn Sci, Dept Appl Phys, Electrum 229, SE-16440 Kista, Sweden;KTH Royal Inst Technol, Swedish E Sci Res Ctr SeRC, SE-10044 Stockholm, Sweden.
    Serry, Mohamed
    AUC, Dept Mech Engn, New Cairo 11835, Egypt.
    Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure2020In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 20, no 1, article id 145Article in journal (Refereed)
    Abstract [en]

    Non-enzymatic glucose sensing is a crucial field of study because of the current market demand. This study proposes a novel design of glucose sensor with enhanced selectivity and sensitivity by using graphene Schottky diodes, which is composed of graphene (G)/platinum oxide (PtO)/n-silicon (Si) heterostructure. The sensor was tested with different glucose concentrations and interfering solutions to investigate its sensitivity and selectivity. Different structures of the device were studied by adjusting the platinum oxide film thickness to investigate its catalytic activity. It was found that the film thickness plays a significant role in the efficiency of glucose oxidation and hence in overall device sensitivity. 0.8-2 mu A output current was obtained in the case of 4-10 mM with a sensitivity of 0.2 mu A/mM.cm(2). Besides, results have shown that 0.8 mu A and 15 mu A were obtained by testing 4 mM glucose on two different PtO thicknesses, 30 nm and 50 nm, respectively. The sensitivity of the device was enhanced by 150% (i.e., up to 30 mu A/mM.cm(2)) by increasing the PtO layer thickness. This was attributed to both the increase of the number of active sites for glucose oxidation as well as the increase in the graphene layer thickness, which leads to enhanced charge carriers concentration and mobility. Moreover, theoretical investigations were conducted using the density function theory (DFT) to understand the detection method and the origins of selectivity better. The working principle of the sensors puts it in a competitive position with other non-enzymatic glucose sensors. DFT calculations provided a qualitative explanation of the charge distribution across the graphene sheet within a system of a platinum substrate with D-glucose molecules above. The proposed G/PtO/n-Si heterostructure has proven to satisfy these factors, which opens the door for further developments of more reliable non-enzymatic glucometers for continuous glucose monitoring systems.

  • Gedin, David
    Replik till Åsa Warnqvist2019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 442-443Article, book review (Other academic)
  • Lysell, Roland
    Marianne Stidsen, Levende litterater. Samtaler om kritikkens guldalder. U-Press. København 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 437-442Article, book review (Other academic)
  • Warnqvist, Åsa
    Slutreplik till David Gedin2019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 443-443Article, book review (Other academic)
  • Olsson, Ulf
    Birthe Sjöberg, Dialog eller dynamit. Viktor Rydberg och August Strindberg – förtryckets fiender. Gidlunds förlag. Möklinta 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 434-437Article, book review (Other academic)
  • Sävborg, Daniel
    Nordic Literature. A Comparative History. Volume I: Spatial nodes. Red. Thomas A. DuBois & Dan Ringgaard. John Benjamin Publishing Company. Amsterdam and Philadelphia 20172019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 429-431Article, book review (Other academic)
  • Haverty Rugg, Linda
    Anna Sofia Rossholm, Ingmar Bergman och den lekfulla skriften. Studier av anteckningar, utkast och filmidéer i arkivets samlingar. Makadam. Göteborg och Stockholm 20172019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 431-434Article, book review (Other academic)
  • Sävborg, Daniel
    Nordens litteratur. Red. Margareta Petersson och Rikard Schönström. Studentlitteratur. Lund 20172019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 422-429Article, book review (Other academic)
  • Jonsson, Bibi
    Martin Kylhammar, Ett hemligt liv. Verner von Heidenstam och Kate Bang. Albert Bonniers förlag. Stockholm 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 412-417Article, book review (Other academic)
  • Sjöberg, Birthe
    Monica Lauritzen, Karl Warburg. Den varsamme vägvisaren. Albert Bonniers förlag. Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 418-422Article, book review (Other academic)
  • Bäckström, Per
    Anders Juhl Rasmussen, Under stadig skælven. Peter Seebergs arkiv og værk. Syddansk Universitetsforlag. Odense 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 406-412Article, book review (Other academic)
  • Israelsson, Per
    Jonas Ingvarsson, Bomber, virus, kuriosakabinett. Texter om digital epistemologi. Rojal Förlag. Göteborg 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 401-406Article, book review (Other academic)
  • Öhrberg, Ann
    Christina Holst Færch, Smædeskrifter, sladder og erotiske vers i 1700-tallet. Hans Nordrups forfatterskab. Med et udvalg af hans digte. Tidlig Moderne, band 14. Museum Tusculanums forlag. Köpenhamn 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 396-399Article, book review (Other academic)
  • Henning, Peter
    Carin Franzén, När vi talar om oss själva. Nedslag i subjektivitetens historia från Montaigne till Norén. Ariel litterär kritik 10. Ariel förlag. Linderöd 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 390-392Article, book review (Other academic)
  • Öhman, Marie
    Henning Howlid Wærp, ”Hele livet en vandrer i naturen”. Økokritiske lesninger i Knut Hamsuns forfatterskap. Orkana Akademisk. Stamsund 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 399-401Article, book review (Other academic)
  • Dahl, Per
    Paula Henrikson, Detta tryckpapperstidevarv. Litterär editionshistoria i Sverige under det långa 1800-talet. Gidlunds förlag. Möklinta 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 393-396Article, book review (Other academic)
  • Svensson, Christina
    Esaias Tegnérs kyrkliga tal del I och II, åren 1813–1823 samt 1824–1830. Utgivna av Barbro Wallgren Hemlin på uppdrag av Tegnérsamfundet. Artos. Skellefteå 2017 och 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 383-387Article, book review (Other academic)
  • Lenemark, Christian
    Margaretha Fahlgren & Birgitta Wistrand, Älska eller älskas. Makt och känslor i politiska biografier. Appell förlag. Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 387-390Article, book review (Other academic)
  • Lindberg, Bo
    Efter Tegnér. Experiment med traditionen. Red. Alfred Sjödin & Jimmie Svensson. Absalon. Lund 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 382-383Article, book review (Other academic)
  • Stenström, Thure
    Jean−François Battail, Alfred Nobel, inconnu célèbre. Regards sur sa vie, son oeuvre et sa postérité. Sorbonne Université Press. Paris 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 376-378Article, book review (Other academic)
  • Haettner Aurelius, Eva
    Almqvistvariationer. Receptionsstudier och omläsningar. Red. Anders Burman och Jon Viklund. Almqviststudier 7. Makadam. Göteborg och Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 371-376Article, book review (Other academic)
  • Pettersson, Jonatan
    Alexanderlegenderna i tid och rum. Alexander den stores gränslösa historia. Red. Karin Hult & Gunhild Vidén. Appell förlag. Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 367-370Article, book review (Other academic)
  • Rydén, Per
    Böckernas tid. Svenska Förläggareföreningen och svensk bokmarknad sedan 1943. Red. Johan Svedjedal. Natur & Kultur. Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 378-382Article, book review (Other academic)
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    Lisa Schmidt, Radera. Tippex, tusch, tråd och andra poetiska tekniker. Glänta produktion. Göteborg 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 363-366Article, book review (Other academic)
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    Lars Liljegren, The Taming of a Viking: August Strindberg, Translation and Post-Victorian Censorship. Linköping Studies in Arts and Sciences 754; Studies in Language and Culture 31. Department of Culture and Communication, Linköping University. Linköping 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 348-353Article, book review (Other academic)
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    Isak Hyltén-Cavallius, Den ofärdiga vetenskapen. Om krisen i svensk litteraturforskning och litteraturtolkningens villkor. Critica Litterarum Lundensis 16, Lunds universitet. Lund 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 337-344Article, book review (Other academic)
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    Hilda Jakobsson, Jag var kvinna. Flickor, kärlek och sexualitet i Agnes von Krusenstjernas tidiga romaner. Stockholms universitet. Makadam. Göteborg och Stockholm 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 344-348Article, book review (Other academic)
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    Sofia Pulls, Skrivande och blivande. Konstruktioner av skönlitterärt skrivande i handböcker och läromedel 1979–2015. Umeå Studies in Educational Sciences 31. Umeå 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 358-363Article, book review (Other academic)
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    Victor Malm, Är det detta som kallas postmodernism? En studie i Katarina Frostensons och Stig Larssons diktning. Lunds Universitet. Lund 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 353-358Article, book review (Other academic)
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    Olga Engfelt, Barndomens poetik. Oscar Parlands Riki-trilogi i den ryska litterära kontexten. Åbo akademis förlag. Åbo 20182019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 333-337Article, book review (Other academic)
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    Matilda Amundsen Bergström, Som en Sapfo. Publiceringsstrategier, självframställning och retorik hos tre tidigmoderna kvinnliga författare. Avhandlingar framlagda vid Institutionen för litteratur, idéhistoria och religion 59, Göteborgs universitet. Göteborg 20192019In: Samlaren: tidskrift för svensk litteraturvetenskaplig forskning, ISSN 0348-6133, E-ISSN 2002-3871, Vol. 140, p. 329-333Article, book review (Other academic)
  • Aydemir, Ufuk
    et al.
    Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China;Huazhong Univ Sci & Technol, Sch Phys, Wuhan 430074, Hubei, Peoples R China.
    Mandal, Tanumoy
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Delhi, Dept Phys & Astrophys, Delhi 110007, India.
    Mitra, Subhadip
    Int Inst Informat Technol, Ctr Computat Nat Sci & Bioinformat, Hyderabad 500032, Telangana, India.
    Addressing the R-D(*) anomalies with an S-1 leptoquark from SO(10) grand unification2020In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 101, no 1, article id 015011Article in journal (Refereed)
    Abstract [en]

    Motivated by the R-D(*) anomalies, we investigate an SO(10) grand unification scenario where a charge -1/3 scalar leptoquark (S-1) remains as the only new physics candidate at the TeV scale. This leptoquark along with the Standard Model (SM) Higgs doublet originates from the same ten-dimensional real scalar multiplet in the SO(10) grand unification framework taking its mass close to the electroweak scale. We explicitly show how the gauge coupling unification is achieved with only one intermediate symmetrybreaking scale at which the Pati-Salam gauge group is broken into the SM group. We investigate the phenomenological implications of our scenario and show that an S-1 with a specific Yukawa texture can explain the R-D(*) anomalies. We perform a multiparameter scan considering the relevant flavor constraints on R-D(*), F-L(D*), P-tau(D*) and R-K(*)(vv) as well as the constraint coming from the Z -> tau tau decay and the latest Dr resonance search data at the LHC. Our analysis shows that a single leptoquark solution to the observed R-D(*) anomalies with S-1 is still a viable solution.