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  • Pettersson, Eva
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Megyesi, Beata
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    The HistCorp Collection of Historical Corpora and Resources2018In: DHN 2018: Proceedings of the Digital Humanities in the Nordic Countries 3rd Conference / [ed] Eetu Mäkelä, Mikko Tolonen, Jouni Tuominen, Helsinki: University of Helsinki, 2018, p. 306-320Conference paper (Refereed)
    Abstract [en]

    We present the HistCorp collection, a freely available open platform aiming at the distribution of a wide range of historical corpora and other useful resources and tools for researchers and scholars interested in the study of historical texts. The platform contains a monitoring corpus of historical texts from various time periods and genres for 14 European languages. The collection is taken from well-documented historical corpora, and distributed in a uniform, standardised format. The texts are downloadable as plaintext, and in a tokenised format. Furthermore, a subset of the corpus contains information on the modern spelling variant, and some of the texts are also annotated with part-of-speech and syntactic structure. In addition, preconfigured n-gram language models and spelling normalisation tools are provided to allow the study of historical languages.

  • Ahl, Malin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Alliansens gestaltning av Ryssland: En diskursanalys av hur den moderatledda regeringen framställde Ryssland i samband med krimkrisen 20142018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-06-05 09:00 Häggsalen, Ångströmlaboratoriet, Uppsala
    Mendoza, Victor
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Aerodynamic Studies of Vertical Axis Wind Turbines using the Actuator Line Model2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis addresses the unsteady aerodynamics involved in the operation of vertical axis wind turbines (VAWTs). The main focus is to represent and understand the most relevant phenomena within the resulting flow pattern as the wake structure, loads on the different turbine components and the performance of the rotor. An actuator line model has been used for this purpose.

    This model has been validated against experimental measurements from diverse cases with different operating conditions in both confined wind tunnels and open site locations. Numerical works were carried out considering a wide range of tip speed ratios (TSRs), and therefore covering from the no stall to the deep stall regime. The latter requires the implementation of a dynamic stall model for the proper representation of the unsteady forces on the blades. Also, different inlet conditions such as a uniform flow, a logarithmic wind shear and an atmospheric boundary layer (ABL) have been tested. The so-called recycling method technique was used to produce the fully developed ABL flow. Additionally, the resulting wake and performance of interacting turbines has been studied.

    Once the model was validated, two numerical study cases for large scale turbines were carried out. First, the performance and resulting flow field from both a horizontal axis wind turbine (HAWT) and VAWT were investigated when the turbines were operating at their optimal TSR and within the same ABL inflow boundary conditions. The influence of the variation on the atmospheric turbulence levels was also studied, as well as the differences and similarities on the obtained results for both type of turbines. Later, the performance improvement of two interacting VAWTs was investigated through the deflected wake produced by the pitched struts of the upstream turbine. This is presented as a novel mechanism to mitigate losses on interacting turbine arrangements (i.e. wind farms).

    In general, there is a reasonable good agreement between numerical results and experimental measurements, and therefore, the applied ALM can be considered as a potential tool for VAWTs simulations, characterized by relatively low computational cost showing accuracy and numerical stability.

    List of papers
    1. Validation of an Actuator Line Model Coupled to a Dynamic Stall Model for Pitching Motions Characteristic to Vertical Axis Turbines
    Open this publication in new window or tab >>Validation of an Actuator Line Model Coupled to a Dynamic Stall Model for Pitching Motions Characteristic to Vertical Axis Turbines
    2016 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    Vertical axis wind turbines (VAWT) can be used to extract renewable energy from wind flows. A simpler design, low cost of maintenance, and the ability to accept flow from all directions perpendicular to the rotor axis are some of the most important advantages over conventional horizontal axis wind turbines (HAWT). However, VAWT encounter complex and unsteady fluid dynamics, which present significant modeling challenges. One of the most relevant phenomena is dynamic stall, which is caused by the unsteady variation of angle of attack throughout the blade rotation, and is the focus of the present study. Dynamic stall is usually used as a passive control for VAWT operating conditions, hence the importance of predicting its effects. In this study, a coupled model is implemented with the open-source CFD toolbox OpenFOAM for solving the Navier-Stokes equations, where an actuator line model and dynamic stall model are used to compute the blade loading and body force. Force coefficients obtained from the model are validated with experimental data of pitching airfoil in similar operating conditions as an H-rotor type VAWT. Numerical results show reasonable agreement with experimental data for pitching motion.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-305170 (URN)10.1088/1742-6596/753/2/022043 (DOI)
    Conference
    The Science of Making Torque from Wind (TORQUE 2016)
    Funder
    StandUp for Wind
    Available from: 2016-10-12 Created: 2016-10-12 Last updated: 2018-04-17Bibliographically approved
    2. Wake Flow Simulation of a Vertical Axis Wind Turbine Under the Influence of Wind Shear
    Open this publication in new window or tab >>Wake Flow Simulation of a Vertical Axis Wind Turbine Under the Influence of Wind Shear
    2017 (English)In: Journal of Physics: Conference Series, Volume 854, conference 1, 2017Conference paper, Published paper (Refereed)
    Abstract [en]

    The current trend of the wind energy industry aims for large scale turbines installed in wind farms. This brings a renewed interest in vertical axis wind turbines (VAWTs) since they have several advantages over the traditional Horizontal Axis Wind Tubines (HAWTs) for mitigating the new challenges. However, operating VAWTs are characterized by complex aerodynamics phenomena, presenting considerable challenges for modeling tools. An accurate and reliable simulation tool for predicting the interaction between the obtained wake of an operating VAWT and the flow in atmospheric open sites is fundamental for optimizing the design and location of wind energy facility projects. The present work studies the wake produced by a VAWT and how it is affected by the surface roughness of the terrain, without considering the effects of the ambient turbulence intensity. This study was carried out using an actuator line model (ALM), and it was implemented using the open-source CFD library OpenFOAM to solve the governing equations and to compute the resulting flow fields. An operational H-shaped VAWT model was tested, for which experimental activity has been performed at an open site north of Uppsala-Sweden. Different terrains with similar inflow velocities have been evaluated. Simulated velocity and vorticity of representative sections have been analyzed. Numerical results were validated using normal forces measurements, showing reasonable agreement.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-348342 (URN)10.1088/1742-6596/854/1/012031 (DOI)
    Conference
    Wake Conference 2017, Visby, May 30-June 1, 2017.
    Funder
    StandUp for Wind
    Available from: 2018-04-11 Created: 2018-04-11 Last updated: 2018-04-17Bibliographically approved
    3. Near-Wake Flow Simulation of a Vertical Axis Turbine Using an Actuator Line Model
    Open this publication in new window or tab >>Near-Wake Flow Simulation of a Vertical Axis Turbine Using an Actuator Line Model
    (English)In: Wind Energy, ISSN 1095-4244, E-ISSN 1099-1824Article in journal (Refereed) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-348688 (URN)
    Funder
    StandUp for Wind
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-05-10
    4. Validation of an Actuator Line and Vortex Model using Normal ForcesMeasurements of a Straight-Bladed Vertical Axis Wind Turbine
    Open this publication in new window or tab >>Validation of an Actuator Line and Vortex Model using Normal ForcesMeasurements of a Straight-Bladed Vertical Axis Wind Turbine
    (English)In: Renewable energy, ISSN 0960-1481, E-ISSN 1879-0682Article in journal (Refereed) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-348689 (URN)
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-04-17
    5. Performance and Wake Comparison of Horizontal and VerticalAxis Wind Turbines Under the Influence of the AtmosphericBoundary Layer
    Open this publication in new window or tab >>Performance and Wake Comparison of Horizontal and VerticalAxis Wind Turbines Under the Influence of the AtmosphericBoundary Layer
    (English)In: Wind Energy, ISSN 1095-4244, E-ISSN 1099-1824Article in journal (Refereed) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-348690 (URN)
    Funder
    StandUp for Wind
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-05-10
    6. Improving Farm Efficiency of Interacting Vertical Axis Wind Turbines Through Wake Deflection Using Pitched Struts
    Open this publication in new window or tab >>Improving Farm Efficiency of Interacting Vertical Axis Wind Turbines Through Wake Deflection Using Pitched Struts
    (English)In: Wind Energy, ISSN 1095-4244, E-ISSN 1099-1824Article in journal (Other academic) Submitted
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-348692 (URN)
    Funder
    StandUp for Wind
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-05-10
  • Söderberg, Camilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Diskursiva positioneringar till de estetiska ämnenas legitimitet: En studie om hur lärare talar om sina kurser i estetiska ämnen sedan gymnasiereformen 20112018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte handlar om att undersöka hur lärare med specifik ämnesprofil talar om estetiska ämnen sedan gymnasiereformen 2011. I studien medverkade verksamma lärare från tre gymnasieskolor i Mellansverige som erbjuder estetiska programmet med inriktning mot bild. Teoretiskt utgår studien från socialkonstruktivismen och diskursteori som perspektiv. Detta betyder att studien bygger på ett antagande om att språket är konstituerande för oss själva och omvärlden. Studien fokuserar på språket som konstruktion och teorin används som utgångspunkt för att kartlägga de diskursiva mönster som framträder i deltagarnas språk och tal. Metodologiskt bygger studien på tre fokusgruppsintervjuer med ett par lärare i varje fokusgrupp.

    Resultatet visar två utmärkande diskurser i sättet att tala om estetiska ämnenas legitimitet, med särskilt fokus på bildämnet. Diskursernas åtskillnad visar å ena sidan ett humanistiskt bildningsideal där estetiska ämnen har ett värde i sig, å andra sidan ett instrumentellt utbildningsideal där estetiska ämnen är till nytta för någonting annat. Diskurserna visar att kunskap har betydelse genom självförverkligande och kreativitet och då kontra det resultatinriktade idealet som handlar om att anpassa innehållet till arbetsmarknadens förändrade krav på kunskap relaterat till olika yrkesinriktningar. Lärarnas utmaningar är legitimering av estetiska programmet som högskoleförberedande utbildning då den terapeutiska stämpeln lever kvar i skolans institution både bland huvudmän, lärare, elever och föräldrar. Det har i sin tur skapat legitimeringsproblematik sedan reformen inrättades då estetiska programmet blev ett högskoleförberedande program. Lärarna framhåller allmänbildningen och den kognitiva förmågan att kommunicera och samspela genom praktisk tillämpning som betydelsefull kunskapsutveckling. Detta skapar i sin tur motsättningar mellan Gy11 och läroplanens resultatinriktade måluppfyllelse, kontra lärarnas uppfattningar om estetiska ämnenas värde, funktion och innehåll. Studien ger uttryck för en avsaknad av estetiska inslag som enligt lärarna innan reformen 2011 varit en del av skolans kultur då estetisk verksamhet ingick som gymnasiegemensamt ämne.

  • Eliasson, Hampus
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Values at Risk2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-06-08 13:15 Siegbahnsalen, Uppsala
    Suntornwipat, Nattakarn
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Diamond Devices Based on Valley Polarization2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Diamond is a wide bandgap semiconductor with extreme properties such as high thermal conductivity, high breakdown field, high carrier mobilities and chemical inertness. These properties together with the possibility to synthesize high purity Single-Crystalline (SC) diamond by Chemical Vapor Deposition (CVD), make it a very interesting material and a candidate for use in power electronics and in hazardous environments. The low impurity concentration achieved when fabricating diamond by CVD allows for a detailed study of the intrinsic electronic properties.

    Diamond has six equivalent conduction band valleys oriented along the {100} axes with a uniquely low scattering rate between them. At low temperatures, the intervalley phonon scattering rate in diamond becomes negligible, which leads to a stable valley polarization state. We have observed non-equilibrium valley populations (valley-polarized electron ensembles), which in turn have been found to result in a Negative Differential Mobility (NDM).

    NDM is commonly only observed in direct bandgap materials such as GaAs, InP and CdTe but our group has also observed NDM in diamond at a temperature range of 100 to 150 K. The occurrence of this phenomenon can be explained by electron repopulation, which is the scattering of electrons between different valleys. If NDM is pronounced enough, electric current instabilities build up and give rise to oscillations. By exploiting this phenomenon, a Transferred-Electron Oscillator (TEO) can be constructed for microwave applications.

    Further investigations into the valley-polarized electrons seen in diamond could bring it forward as an alternative material for use in electronic devices. This use, called valleytronics, is similar to spintronics but instead of using the electron spin, the polarization in the conduction band valleys is used to transfer information. Digital electronic circuits use the presence or absence of charge to encode information which relies on a rapid redistribution of mobile charge carriers. This requires energy which results in losses and thus sets a theoretical limit to the maximum switching frequency. This is one of the main issues of electronic devices and can be mitigated by using alternative technologies such as spintronics or valleytronics.

    In order to get a better understanding of the electron valley repopulation effects, the focus of this doctoral thesis is the study of electron charge transport in SC-CVD diamond at low temperatures. The thesis also aims at using valley-polarized states as a foundation for the creation of electronic devices such as TEOs or valley-transistors, out of diamond.

    List of papers
    1. Magnetotransport study of valley-polarized electrons in synthetic diamond
    Open this publication in new window or tab >>Magnetotransport study of valley-polarized electrons in synthetic diamond
    Show others...
    2016 (English)In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 94, no 3, article id 035408Article in journal (Refereed) Published
    Abstract [en]

    We demonstrate that the highly stable valley-polarized electron states in ultrapure single-crystalline diamond allow for investigation of charge transport, magnetoresistivity, and determination of the dominant scattering mechanism. The Hall effect gives rise to nonisotropic contributions in the mobility tensor that were measured at a temperature of 70 K in a time-of-flight setup with an added magnetic field. The observations of the magnetotransport of valley-polarized electrons in diamond are compared with both Monte Carlo simulations and an analytical model based on the Boltzmann transport equation. We establish that acoustic phonon scattering is the dominant electron scattering mechanism at 70 K for each of the valley polarizations in the investigated samples.

    National Category
    Condensed Matter Physics Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-300466 (URN)10.1103/PhysRevB.94.035408 (DOI)000379717700005 ()
    Funder
    Swedish Research Council, 621-2014-6026ÅForsk (Ångpanneföreningen's Foundation for Research and Development), 15-288Swedish National Infrastructure for Computing (SNIC), SNIC2014-3-65
    Available from: 2016-08-09 Created: 2016-08-09 Last updated: 2018-04-15Bibliographically approved
    2. Investigation of transferred-electron oscillations in diamond
    Open this publication in new window or tab >>Investigation of transferred-electron oscillations in diamond
    2016 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 108, no 21, article id 212104Article in journal (Refereed) Published
    Abstract [en]

    The recent discovery of Negative Differential Mobility (NDM) in intrinsic single-crystalline diamond enables the development of devices for high frequency applications. The Transferred-Electron Oscillator (TEO) is one example of such devices that uses the benefit of NDM to generate continuous oscillations. This paper presents theoretical investigations of a diamond TEO in the temperature range of 110 to 140K where NDM has been observed. Our simulations map out the parameter space in which transferred-electron oscillations are expected to occur for a specific device geometry. The results are promising and indicate that it is possible to fabricate diamond based TEO devices.

    National Category
    Condensed Matter Physics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-298901 (URN)10.1063/1.4952766 (DOI)000377024400026 ()
    Funder
    Swedish Research Council, 621-2012-5819The Royal Swedish Academy of SciencesÅForsk (Ångpanneföreningen's Foundation for Research and Development), 15-288
    Note

    Correction in: Applied Physics Letters 108(23) article number 239901 DOI: 10.1063/1.4953887

    Available from: 2016-07-12 Created: 2016-07-12 Last updated: 2018-04-15Bibliographically approved
    3. Low temperature conduction-band transport in diamond
    Open this publication in new window or tab >>Low temperature conduction-band transport in diamond
    Show others...
    2016 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 109, no 16, article id 162106Article in journal (Refereed) Published
    Abstract [en]

    By performing Time-of-Flight measurements on high-purity single-crystalline chemical vapor deposited diamond, we are able to extract the electron drift velocity of valley-polarized electrons in the low-injection regime. The aim of this study is to improve the understanding of the mechanisms involved in the conduction-band transport of valley-polarized electrons. The measurements were carried out within the temperature range of 10-80 K, and the experimental results are systematically compared with Monte Carlo charge transport simulations. We observe a rapid enhancement of the electron mobility with decreasing temperature, which reveals that inelastic effects in electron-phonon scattering become important below similar to 40 K. In addition, we obtain the momentum relaxation rate for electrons with different valley polarizations.

    National Category
    Condensed Matter Physics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-310010 (URN)10.1063/1.4964720 (DOI)000386933200020 ()
    Funder
    Swedish Research Council, 621-2014-6026ÅForsk (Ångpanneföreningen's Foundation for Research and Development), 15-288Carl Tryggers foundation , 14:151 15:225Swedish National Infrastructure for Computing (SNIC), SNIC2014-3-65
    Available from: 2016-12-12 Created: 2016-12-09 Last updated: 2018-04-15Bibliographically approved
    4. Stability of polarized states for diamond valleytronics
    Open this publication in new window or tab >>Stability of polarized states for diamond valleytronics
    Show others...
    2014 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 104, no 23, p. 232105-Article in journal (Refereed) Published
    Abstract [en]

    The stability of valley polarized electron states is crucial for the development of valleytronics. A long relaxation time of the valley polarization is required to enable operations to be performed on the polarized states. Here, we investigate the stability of valley polarized states in diamond, expressed as relaxation time. We have found that the stability of the states can be extremely long when we consider the electron-phonon scattering processes allowed by symmetry considerations. We determine electron-phonon coupling constants by Time-of-Flight measurements and Monte Carlo simulations and use these data to map out the relaxation time temperature dependency. The relaxation time for diamond can be microseconds or longer below 100 K and 100 V/cm due to the strong covalent bond, which is highly encouraging for future use in valleytronic applications. (C) 2014 AIP Publishing LLC.

    National Category
    Engineering and Technology Physical Sciences
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-229299 (URN)10.1063/1.4882649 (DOI)000337891200043 ()
    Available from: 2014-08-06 Created: 2014-08-05 Last updated: 2018-04-15Bibliographically approved
    5. Charge Transport Phenomena Unique to Diamond
    Open this publication in new window or tab >>Charge Transport Phenomena Unique to Diamond
    Show others...
    2014 (English)In: MRS Online Proceedings Library, Vol. 1591, p. null-nullArticle in journal (Refereed) Published
    Abstract [en]

    ABSTRACT Diamond is a unique material in many respects. One of the most well-known extreme properties of diamond is its ultrahardness. This property of diamond actually turns out to have interesting consequences for charge transport, in particular at low temperatures. In fact, the strong covalent bonds that give rise to the ultrahardness results in a lack of short wavelength lattice vibrations which has a strong impact on both electron and hole scattering. In some sense diamond behaves more like a vacuum than other semiconductor materials. In this paper we describe some interesting charge transport properties of diamond and discuss possible novel electronic applications.

    Place, publisher, year, edition, pages
    Cambridge Journals Online, 2014
    Keyword
    diamond, electrical properties, electron-phonon interactions
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-237485 (URN)10.1557/opl.2014.295 (DOI)null (ISBN)
    Available from: 2014-12-03 Created: 2014-12-03 Last updated: 2018-04-15
    6. Electrostatic control of valley pseudospin in dual-gate diamond transistors
    Open this publication in new window or tab >>Electrostatic control of valley pseudospin in dual-gate diamond transistors
    Show others...
    (English)In: Nature Materials, ISSN 1476-1122, E-ISSN 1476-4660Article in journal (Refereed) Submitted
    National Category
    Other Materials Engineering
    Identifiers
    urn:nbn:se:uu:diva-348548 (URN)
    Available from: 2018-04-15 Created: 2018-04-15 Last updated: 2018-04-15
    7. Transferred-electron oscillators based on diamond
    Open this publication in new window or tab >>Transferred-electron oscillators based on diamond
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Materials Engineering
    Identifiers
    urn:nbn:se:uu:diva-348550 (URN)
    Available from: 2018-04-15 Created: 2018-04-15 Last updated: 2018-04-15
  • Devera La Rosa, Adriana Patricia
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Business Intelligence and Analyticsapplied to a collaboration platform2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Idefusion AB is a start-up company which has developed a platform tosimplify the collaborative process between companies’ employees,university students and people in private life. Their main focus lieson skilled people such as company employees to produce cases based onproblems in their work life. These problems can be solved togetherwith students in an interactive environment where the employee canask, follow up questions and create a crowdfunding environment ofideas. The platform is created for multiple usage areas, such as tomake possible for students to interact with a company representative(e.g. a recruiter) and build a valuable network with it, this usageincludes interactions between professors and students for differentsubjects. At the same time, employees can use their platform as bothan intranet and a tool to develop ideas and recruit knowledgeablestudents.

    The platform manages profiles with different type or users, where eachuser can have multiple profiles, related them to different type oforganisations such as either companies or universities. These profileshave their own features with separated modules, but the profile typesare accessible from each other but separating their user informationand give them different tools depending on their organisation type.Idefusion AB receives a big amount of data that come from users whouses the features included at the platform.

    In order to gain an increasing insight about their users, Idefusion ABwants to adopt their own BI&A module according to their needs, thisresearch has included a variety usage of different BI&A tools such asTableau, Piwik, Open Web, SAS, Google AdSense + Google Analytics, andclient server insights; all for increasing the understanding on how tosee insight from the extraction of the user’s data hosted in a cloudservice called AWS, all these tools were compared according to their features.

    The insights were possible to extract by creating scripts added toIdefusion pages with the purpose of connecting the platform with thetools for to observe what do they bring, what do they offer and for tosee the usability of the platform in general.

    After getting results from the insights Idefusion AB confirmed theirneeds to create and developed their own BI&A module, this to get theirdata in a specific way, for making a decision of developing furthertheir actual features or creating new ones.

  • Arnberg, Rickard
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Thunqvist, Josefin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    "Vadå undervisning? Dom är väl för små för att lära sig så här mycket saker?": En kvalitativ studie om förskollärares och förskollärarstudenters uppfattning av begreppet undervisning2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie syftar till att undersöka hur förskollärare och förskollärarstudenter uppfattar begreppet undervisning samt hur de anser att undervisning kan bedrivas i förskolan, vidare presenteras även de skillnader som går att utläsa mellan dessa två respondentgrupper.Studiens teoretiska ramverk utgörs av det sociokulturella perspektivet, forskning kring undervisning och lärande ur ett didaktiskt perspektiv samt definitioner av begreppet undervisning. Studien bygger på en kvalitativ forskningsmetod där semistrukturerade intervjuer använts för att samla in empiri som bearbetats genom en analytisk induktion.Resultatet visar att förskollärarstudenter ställer sig skeptiska till användandet av begreppet undervisning då det uppfattas kravfyllt och associeras med en mer strikt planerad verksamhet. Förskollärare uppvisar däremot en mer pragmatisk syn på begreppet och ser generellt inga problem med att använda sig av det i förskolan. Vidare gick att urskilja paralleller mellan förskollärare och förskollärarstudenters uppfattning av begreppet undervisning och hur den kan bedrivas vilket exempelvis yttrar sig genom att förskollärarstudenters mer negativa uppfattning av undervisning gör dem mindre benägna att vilja undervisa i förskolan.

  • Andersson, Sandra
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Olforser, Sanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    "En förskola för alla": Hur inkluderar pedagoger barn med funktionsnedsättning i eller under lässamlingar?2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien är att undersöka hur förskollärare anpassar lässtunden för att inkludera barn med funktionsnedsättning samt hur stor andel barnlitteratur som behandlar barn med funktionsnedsättning som det finns i förskolan. För att hålla en röd tråd i arbetet och för att uppnå studiens syfte utformade vi två frågeställningar:

    Vilka metoder använder förskollärare för att inkludera barn med funktionsnedsättning i vardagliga aktiviteter som lässtunden? I vilken omfattning har barnen och arbetslaget på förskolan tillgång till barnlitteratur som berör barn med funktionsnedsättning?

    Studiens material samlades via två delstudier, en kvantitativ enkätundersökning och fem kvalitativa intervjuer. Dessa metoder valdes ut för att ge ett mätningsbart resultat samt ett reflekterande resultat där det går att urskilja likheter och skillnader i teorin och praktiken. Utifrån sammanställningarna av de båda delstudierna har vi tillsammans kritiskt analyserat resultaten och fört en diskussion.

    Bakgrunden till studien grundas på våra egna erfarenheter av ett inkluderande förhållningssätt i barngruppen samt urvalet av barnlitteratur som finns tillgängligt. Vi har själva uppfattat att pedagoger exkluderar barn med funktionsnedsättning med

    låt-gå-pedagogik istället för att inkluderar in samtliga barn i förskolans verksamhet. Vi har även uppmärksammat hur lite barnlitteratur det finns tillgängligt som handlar om barn med funktionsnedsättning.

    I resultatet framkom det att flera pedagoger i dagens förskoleverksamhet anser att variationen på dagens barnlitteratur inte följer med i samhällets utveckling, det behövs ett bredare utbud. Det framkom även att det endast krävs små förändringar i pedagogernas förhållningssätt för att alla barnen ska inkluderas in i barngruppen för att kunna ta del av lärandet som sker i grupp. Av resultatet kan vi utläsa att barnlitteraturen behöver en större bredd och variation samtidigt som pedagogerna bara behöver göra små förändringar i sin pedagogik för att alla barnen ska känna sig delaktiga.

    Studiens centrala begrepp är inkludering. Vi valde begreppet eftersom det inte bara innefattar verksamhetens miljö och pedagogernas pedagog, begreppet innefattar också materialet som finns tillgängligt och lärande materialet som används i förskolan.

    Studie utgår från ett sociokulturellt perspektiv med fokus på lärande som sker i samspel med andra.

  • Brandell, Klara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Musikskapande barn: En observationsstudie om barns musikaliska skapande i förskolan2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie har haft till syfte att undersöka hur barn skapar och tar sig an musik i förskolan. Huvudfokus har legat på barnen och deras initiativ men jag har även observerat pedagoger eftersom de är en del av den miljö och kontext som barnen befinner sig i. Studien, som är en kvalitativ fallstudie bestående av direkt observation och videoupptagning, utfördes på en förskola i en stor svensk stad under tre dagar i mars 2018. Deltagarna var sexton barn mellan två och tre år samt sju pedagoger; tre förskollärare och fyra barnskötare. Resultaten har analyserats utifrån begreppen kreativitet, improvisation, produktion och reproduktion med fokus på barns spontana ljudskapande.I resultatet framkom att barnen musicerade och skapade ljud nästan konstant och att musiken kunde ha diverse olika funktioner. Några vanliga funktioner var kommunikation, samspel och självuttryck och musiken användes ofta som medierande verktyg i barnens strävan att ta sig an omvärlden. Den vanligaste formen av musikaliskt skapande var dans till förinspelad musik samt spontan sång. Spontan sång uppstod i alla möjliga situationer, så som sångsamling, fri lek och vid lunchen. Pedagogerna visade på två huvudsakliga reaktioner på barns spontana sång; den ena var att de tystade barnen eftersom ljudskapandet inte föll inom ramen för den aktuella aktiviteten och den andra var snarare en icke-reaktion, då pedagogerna i de flesta fall inte lade märke till barnens ljudskapande. Mina slutsatser utifrån denna studie är att barns musikskapande sker hela tiden, men oftast inte uppmärksammas av pedagogerna samt att det behövs mer forskning om barns spontana och kreativa skapande.

  • Public defence: 2018-06-08 14:15 Auditorium Minus, Uppsala
    Nordin, Kristin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Aging Along the Hippocampal Axis: Structure, Function and Whole-brain Connections in Association with Memory2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Hippocampus-dependent functions display marked reductions in older age, an observation that has led to the extensive study of age effects on hippocampal properties. Even though research indicates that the hippocampus is structurally and functionally heterogeneous along its longitudinal axis, its anterior and posterior regions differentially supporting episodic and spatial memory representations, few studies explicitly consider age effects in relation to axis. Relatedly, as men and women commonly differ in episodic and spatial memory performance, and sometimes also in rates of age-related hippocampal atrophy, sex could be a potential modifier of age effects. The aim of this thesis was therefore to assess age effects on the hippocampus and its role in episodic and spatial memory across young (20-35 years), middle-aged (40-50 years) and older (60-70 years) adults, adopting a longitudinal-axis approach while considering interactions with sex. Study I evaluated hippocampal volume and activation in relation to associative memory across middle-aged and older adults. Age differences in associative memory were largest in men and paralleled by smaller volumes and less activation in the anterior hippocampus. Study II assessed hippocampus-dependent network-like organization of gray matter by measures of structural whole-brain covariance. The anterior and posterior hippocampus showed shared and distinct patterns of covariance, which were qualitatively comparable across age groups. However, participants’ expression of these patterns decreased as a function of age, comparably for men and women, and showed significant associations with episodic memory. Study III investigated age effects on resting-state functional connectivity and demonstrated that both the anterior and posterior hippocampus decreased in connectivity with several brain regions across middle-aged and older adults. Memory was only associated with age-related connectivity of the posterior hippocampus: episodic memory negatively with connectivity increasing as a function of age, and spatial memory positively with connectivity that decreased. These studies demonstrate distinct effects of age on the anterior and posterior hippocampus, and show that age-related decline of these regions differentially relates to episodic and spatial memory. Overall, findings highlight the importance of explicitly considering the heterogeneity of the hippocampal axis in the assessment of its role in age-related memory decline.

    List of papers
    1. Overlapping effects of age on associative memory and the anterior hippocampus from middle to older age
    Open this publication in new window or tab >>Overlapping effects of age on associative memory and the anterior hippocampus from middle to older age
    2017 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 317, p. 350-359Article in journal (Refereed) Published
    Abstract [en]

    The anterior hippocampus has been implicated in associative memory, and along with hippocampal volume, this type of memory declines with age. However, few cross-sectional studies include middle-aged samples, making it unclear at what point these age-related changes occur. In addition, although men and women have been shown to differ in associative memory and rates of age-related hippocampal atrophy, sex-differences in aging are rarely studied. To address these issues, we assessed memory for word-pairs, hippocampal volume and activation during encoding and retrieval, across middle-aged (n=39) and older (n=44) participants, specifically in relation to sex. Older adults showed significantly poorer associative memory compared to middle-aged adults, paralleled by smaller anterior hippocampi and less activation during successful retrieval. The age-by-sex interaction observed in memory performance was also mirrored in the volume and activation of the hippocampus, indicating more pronounced age-effects in men as compared to women. These results indicate a specific role of the anterior hippocampus in verbal associative memory and suggest they both decline between middle-age and older age.

    Keyword
    Aging, Episodic memory, Event-related activation, fMRI, Sex, Voxel-based morphometry
    National Category
    Neurology
    Identifiers
    urn:nbn:se:uu:diva-305754 (URN)10.1016/j.bbr.2016.10.002 (DOI)000389086700038 ()27713000 (PubMedID)
    Funder
    Swedish Research Council, VR 2011-1943
    Available from: 2016-10-21 Created: 2016-10-21 Last updated: 2018-04-17Bibliographically approved
    2. Structural whole-brain covariance of the anterior and posterior hippocampus: Associations with age and memory
    Open this publication in new window or tab >>Structural whole-brain covariance of the anterior and posterior hippocampus: Associations with age and memory
    Show others...
    2018 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 28, no 2, p. 151-163Article in journal (Refereed) Published
    Abstract [en]

    The hippocampus (HC) interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole-brain structural covariance. It is also unclear whether the anterior and posterior HC show similar or distinct patterns of whole-brain covariance and to what extent these are related to memory functions organized along the hippocampal longitudinal axis. Using the multivariate approach partial least squares, we assessed structural whole-brain covariance of the HC in addition to regional volume, in young, middle-aged and older adults (n = 221), and assessed associations with episodic and spatial memory. Based on findings of sex differences in both memory and brain aging, we further considered sex as a potential modulating factor of age effects. There were two main covariance patterns: one capturing common anterior and posterior covariance, and one differentiating the two regions by capturing anterior-specific covariance only. These patterns were differentially related to associative memory while unrelated to measures of single-item memory and spatial memory. Although patterns were qualitatively comparable across age groups, participants' expression of both patterns decreased with age, independently of sex. The results suggest that the organization of hippocampal structural whole-brain covariance remains stable across age, but that the integrity of these networks decreases as the brain undergoes age-related alterations.

    Keyword
    aging, episodic memory, longitudinal axis, sex, spatial memory
    National Category
    Neurology
    Identifiers
    urn:nbn:se:uu:diva-335505 (URN)10.1002/hipo.22817 (DOI)29171897 (PubMedID)
    Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2018-05-09Bibliographically approved
    3. Age-related hippocampal resting-state connectivity shows axis-dependent associations with memory
    Open this publication in new window or tab >>Age-related hippocampal resting-state connectivity shows axis-dependent associations with memory
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Functional connectivity across large-scale brain networks alters in older age and changes are often associated with memory decline. Studies assessing hippocampal resting-state functional connectivity (rsFC), however, rarely consider the anterior and posterior hippocampus separately, although evidence suggests they are part of two distinct networks differentially supporting memory. While only a limited number of studies have considered age effects on axis-related hippocampal connectivity, findings suggest that rsFC of the two regions display differential effects of age. Reports on the link between such effects and memory are however inconclusive, and previous findings mainly concern episodic memory, ignoring spatial memory also dependent on the hippocampus. Here, we therefore assessed age effects on axis-related hippocampal rsFC, accounting for associations with both episodic and spatial memory in young, middle-aged and older adults (n=194). The anterior and posterior hippocampus showed different age-related decreases in connectivity assessed across middle and older age, but common to the regions was a decreased coupling with the medial orbitofrontal cortex. Only connectivity between the posterior hippocampus and the lingual gyrus increased as a function of age, displaying negative associations with episodic memory. In contrast, the region’s connectivity with the insula, decreasing with age, was positively related to spatial memory. Consistent with previous reports, our findings indicate that hippocampal rsFC vary with age in an axis-dependent manner, and further add to the knowledge on this differentiation’s relevance to memory by showing that age-related rsFC of the anterior and posterior hippocampus is differentially associated with episodic and spatial memory.

    Keyword
    Aging, Episodic Memory, Hippocampus, Longitudinal axis, Sex, Spatial Memory
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-348685 (URN)
    Available from: 2018-04-17 Created: 2018-04-17 Last updated: 2018-04-17
  • Aaboud, M.
    et al.
    Univ Mohamed Premier, Fac Sci, Oujda, Morocco.;LPTPM, Oujda, Morocco..
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Georg August Univ, Phys Inst 2, Gottingen, Germany.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland..
    Searches for heavy ZZ and ZW resonances in the ℓℓqq and ννqq final states in pp collisions at √s=13 TeV with the ATLAS detector2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 3, article id 009Article in journal (Refereed)
    Abstract [en]

    This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of root s - 13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb(-1), were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of light charged leptons (electrons and muons) or a pair of neutrinos, and the associated W boson or the other Z boson decays hadronically. No evidence of the production of heavy resonances is observed. Upper bounds on the production cross sections of heavy resonances times their decay branching ratios to ZZ or ZW are derived in the mass range 300-5000 GeV within the context of Standard Model extensions with additional Higgs bosons, a heavy vector triplet or warped extra dimensions. Production through gluon-gluon fusion, Drell-Yan or vector-boson fusion are considered, depending on the assumed model.

  • Public defence: 2018-06-05 13:15 Hörsal 2, Ekonomikum, Uppsala
    Edlund, Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Constructing an Arbiter of Status: A Study of the European Research Council's Emergence in the Field of Science2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The aim of this thesis is to shed light on how certain actors are constructed into third-party arbiters of status. Such arbiters mediate the triadic relations in which status is created, assessing and suggesting certain candidates as particularly worthy of deference from audiences.

    While previous literature has provided us with compelling insights into the pervasive authority of status arbiters, less attention has been paid to the ways in which these arbiters reach their authoritative positions. I seek to build new knowledge on the processes through which third-party status arbiters are constructed by exploring how the European Research Council (ERC) was transformed into an authority in science. In a short period of time, the ERC’s evaluations of funding applications and subsequent allocations of research resources came to be approached as a benchmark of scientific quality, which scientists, departments, universities, and countries anxiously compared their research performance with. I suggest that these evaluations and allocations soon became more than instances in which quality was assessed and resources were distributed, thus turning into potent bases for status creation as well.

    In three empirical chapters, which draw upon documents, interviews, and observations, I place the ERC within the context of a field, showing how its construction into a third-party status arbiter needs to be understood as a process that unfolded over time. First, I look at major tensions and struggles that surrounded Europe-level science in the advent of the ERC’s founding. Then, I examine the active efforts with which the ERC attempted to engender acceptance for its evaluations of Starting Grant (StG) funding applications. Finally, I explore the status consequences of ERC StG allocations for the careers of scientists, the milieus within departments, and the relations between universities in Sweden.

    My findings contribute to previous literature by demonstrating how arbiters are constructed through mutually reinforcing relations in which the status-creating potential of evaluations is continuously framed and validated. My findings also contribute by showing how the creation of status over time requires constant maintenance efforts to sustain the agreement between arbiters and audiences in terms of candidates that are worthy of deference.

  • Davidsson, Linus
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Du är alltså är Jag: En undersökning av Martin Bubers teori om skuld i ljuset av hans människosyn och etik2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-06-05 10:00 Hambergssalen, Uppsala
    Svensson, Nina
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Mesoscale Processes over the Baltic Sea2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The objective of this thesis is to study mesoscale processes above the Baltic Sea, which is a small, semi-enclosed sea where land-sea interaction may have a large impact on the offshore conditions. It is only the last tens of years that offshore research has become more popular, and one reason for this is the increasing offshore wind energy, which poses the need for accurate estimates of wind speed and turbulence conditions in the marine environment. In this thesis a range of mesoscale processes over the Baltic Sea are studied using the mesoscale model WRF (Weather Research and Forecasting) and different types of measurements.It is found that mesoscale effects are largest during spring and summer, when stable conditions dominate. The whole Baltic sea surface is affected by warm-air advection and low-level jets. There is very little spatial variation in seasonally averaged fields, which shows that the extent of mesoscale effects is several hundred kilometres. Wind speed and temperature profiles can thus not be described solely by the local conditions even far out over sea surface. Sea breezes are relatively unimportant for modyfing the seasonally averaged wind fields, but other types of low-level jets have a large influence. Results show that most of the low-level jets are likely created by inertial oscillations initiated when air flows across a coastline from the convective land surface to stable sea surface.Evaluation of the model shows that the discrepancies are largest during very stable conditions, but are also quite large during very unstable. The reasons for this are discussed.Several cases of boundary layer rolls are investigated using measurements and simulations and it is found that the rolls are likely created over the convective mainland and advected out over the stable sea surface, which may be a new finding that has not been reported before.

    List of papers
    1. Stable conditions over the Baltic sea: model evaluation and climatology
    Open this publication in new window or tab >>Stable conditions over the Baltic sea: model evaluation and climatology
    2016 (English)In: Boreal environment research, ISSN 1239-6095, E-ISSN 1797-2469, Vol. 21, p. 387-404Article in journal (Refereed) Published
    Abstract [en]

    The WRF (Weather Research and Forecasting model) was evaluated against flight measurements over the Baltic Sea during stable conditions, focusing on vertical profiles of temperature and wind speed. Six different boundary layer parameterization schemes were used. It is shown that there are generally small differences between the boundary layer schemes, and that all schemes have problems in capturing the strength and height of low-level jets. Climatological simulations over the Baltic Sea show that there is a strong sea-sonality in the stability over the sea with up to 80% stable conditions in spring as compared with 10% in winter. Low-level jets are common, and occur up to 45% of the time in spring. The entire Baltic Sea, not only its coastal areas, is affected by stable stratification.

    Keyword
    stable conditions, boundary layer, Baltic sea, WRF, low level jet, coastal area
    National Category
    Meteorology and Atmospheric Sciences
    Research subject
    Meteorology
    Identifiers
    urn:nbn:se:uu:diva-287952 (URN)
    Funder
    StandUp for WindNational Supercomputer Centre (NSC), Sweden, SNIC 2015/1-224
    Available from: 2016-04-27 Created: 2016-04-27 Last updated: 2018-04-12
    2. A Case Study of Offshore Advection of Boundary Layer Rolls over a Stably Stratified Sea Surface
    Open this publication in new window or tab >>A Case Study of Offshore Advection of Boundary Layer Rolls over a Stably Stratified Sea Surface
    Show others...
    2017 (English)In: Advances in Meteorology, ISSN 1687-9309, E-ISSN 1687-9317, Vol. 2017, article id 9015891Article in journal (Refereed) Published
    Abstract [en]

    Streaky structures of narrow (8-9 km) high wind belts have been observed from SAR images above the Baltic Sea during stably stratified conditions with offshore winds from the southern parts of Sweden. Case studies using the WRF model and in situ aircraft observations indicate that the streaks originate from boundary layer rolls generated over the convective air above Swedish mainland, also supported by visual satellite images showing the typical signature cloud streets. The simulations indicate that the rolls are advected and maintained at least 30-80 km off the coast, in agreement with the streaks observed by the SAR images. During evening when the convective conditions over land diminish, the streaky structures over the sea are still seen in the horizontal wind field; however, the vertical component is close to zero. Thus advected feature from a land surface can affect the wind field considerably for long times and over large areas in coastal regions. Although boundary layer rolls are a well-studied feature, no previous study has presented results concerning their persistence during situations with advection to a strongly stratified boundary layer. Such conditions are commonly encountered during spring in coastal regions at high latitudes.

    Keyword
    boundary layer rolls, coastal transition, stable conditions
    National Category
    Meteorology and Atmospheric Sciences
    Research subject
    Meteorology
    Identifiers
    urn:nbn:se:uu:diva-306939 (URN)10.1155/2017/9015891 (DOI)000414082500001 ()
    Projects
    StandUp for Wind
    Funder
    National Supercomputer Centre (NSC), Sweden, 2015/1-224StandUp for Wind
    Available from: 2016-11-07 Created: 2016-11-07 Last updated: 2018-04-12Bibliographically approved
    3. Modification of the Baltic Sea wind field by land-sea interaction
    Open this publication in new window or tab >>Modification of the Baltic Sea wind field by land-sea interaction
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Meteorology and Atmospheric Sciences
    Identifiers
    urn:nbn:se:uu:diva-348369 (URN)
    Available from: 2018-04-12 Created: 2018-04-12 Last updated: 2018-04-12
    4. Offshore wind speed profiles: Investigating variations using WRF simulations and LIDAR measurements
    Open this publication in new window or tab >>Offshore wind speed profiles: Investigating variations using WRF simulations and LIDAR measurements
    (English)Manuscript (preprint) (Other academic)
    National Category
    Meteorology and Atmospheric Sciences
    Identifiers
    urn:nbn:se:uu:diva-348372 (URN)
    Available from: 2018-04-12 Created: 2018-04-12 Last updated: 2018-04-12
  • Medina, Anya
    et al.
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Parween, Saba
    Umea Univ, Umea Ctr Mol Med, Umea, Sweden..
    Ullsten, Sara
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Vishnu, Neelanjan
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Siu, Yuk Ting
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Quach, My
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Bennet, Hedvig
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Balhuizen, Alexander
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Åkesson, Lina
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Wierup, Nils
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Ahlgren, Ulf
    Umea Univ, Umea Ctr Mol Med, Umea, Sweden..
    Lernmark, Åke
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Fex, Malin
    Lund Univ, Ctr Diabet, Clin Res Ctr, Skane Univ Hosp SUS, Jan Waldentromsgata 35, SE-20502 Malmo, Sweden..
    Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats2018In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 4, p. 896-905Article in journal (Refereed)
    Abstract [en]

    Aims/hypothesis Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. Methods We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ littermates (controls) to investigate beta cell function in vivo, and insulin and glucagon secretion in vitro. Beta cell mass was assessed by optical projection tomography (OPT) and morphometry. Additionally, measurements of intra-islet blood flow were performed using microsphere injections. We also assessed immune cell infiltration, cytokine expression in islets (by immunohistochemistry and qPCR), as well as islet Glut2 expression and ATP/ADP ratio to determine effects on glucose uptake and metabolism in beta cells. Results DRLyp/Lyp rats were normoglycaemic and without traces of immune cell infiltrates. However, IVGTTs revealed a significant decrease in the acute insulin response to glucose compared with control rats (1685.3 +/- 121.3 vs 633.3 +/- 148.7; p < 0.0001). In agreement, insulin secretion was severely perturbed in isolated islets, and both first- and second-phase insulin release were lowered compared with control rats, while glucagon secretion was similar in both groups. Interestingly, after 5-7 days of culture of islets from DRLyp/Lyp rats in normal media, glucose-stimulated insulin secretion (GSIS) was improved; although, a significant decrease in GSIS was still evident compared with islets from control rats at this time (7393.9 +/- 1593.7 vs 4416.8 +/- 1230.5 pg islet(-1) h(-1); p < 0.0001). Compared with controls, OPT of whole pancreas from DRLyp/Lyp rats revealed significant reductions in medium (4.1 x 10(9) +/- 9.5 x 10(7) vs 3.8 x 10(9) +/- 5.8 x 10(7) mu m(3); p = 0.044) and small sized islets (1.6 x 10(9) +/- 5.1 x 10(7) vs 1.4 x 10(9) +/- 4.5 x 10(7) mu m(3); p = 0.035). Finally, we found lower intra-islet blood perfusion in vivo (113.1 +/- 16.8 vs 76.9 +/- 11.8 mu l min(-1) [g pancreas](-1); p = 0.023) and alterations in the beta cell ATP/ADP ratio in DRLyp/Lyp rats vs control rats. Conclusions/interpretation The present study identifies a deterioration of beta cell function and mass, and intra-islet blood flow that precedes insulitis and diabetes development in animals prone to autoimmune type 1 diabetes. These underlying changes in islet function may be previously unrecognised factors of importance in type 1 diabetes development.

  • Bohman, Jerker
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy.
    En kritik av Hardins livbåtsetik2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-06-06 09:15 Enghoffsalen, Uppsala
    Schiller, Petter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Thoracic Surgery.
    Mechanical Circulatory Support in Left Ventricular Heart Failure2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Short-term mechanical circulatory support (MCS) with ventricular assist devices or veno-arterial extracorporeal membrane oxygenation (VA ECMO) has become the standard treatment in patients with cardiogenic shock unresponsive to pharmacological treatment. However, the haemodynamic effects of these devices are not yet fully described, nor are their effects on ventricular function and myocardial recovery.

    The aims of this thesis are to increase knowledge of the haemodynamic changes during MCS in different settings and to provide new insights into how MCS therapy should be guided in the specific patient.

    In Studies I and II, we developed experimental animal models to investigate the effect of VA ECMO on left ventricular (LV) performance and size of myocardial infarction in different cannulation strategies. In Study I, we found that the LV performance was negatively affected by VA ECMO in both centrally and peripherally cannulated animals. In Study II, we specifically studied the effect of VA ECMO with and without the addition of LV drainage on the size of experimentally induced myocardial infarction. The results showed that active LV decompression had no effect on infarct size in the acute setting.

    Studies III and IV are retrospective studies on patients in cardiogenic shock treated with short-term mechanical support with either Impella® (Studies III and IV) or VA ECMO (Study IV). In Study IV, we concluded that treatment with Impella® has excellent effects on haemodynamic parameters and an acceptable mortality and complication rate. The studied pre-implantation patient parameters did not significantly affect outcome. In Study IV, we compared the outcome of patients treated with Impella® with those treated with VA ECMO. After adjustment for pre-implantation patient status, as defined by SAVE score, no difference in short- or long-term mortality was seen between the two groups.

    In conclusion, VA ECMO, whether central or peripheral, negatively affects the LV, and the addition of a LV drain has no effect on infarct size in these experimental models. Both Impella® and VA ECMO offer good haemodynamic results with acceptable mortality and complication rates in patients with refractory cardiogenic shock. When adjusted for the SAVE score, the outcomes of both treatment modalities are comparable.

    List of papers
    1. Experimental Venoarterial Extracorporeal Membrane Oxygenation Induces Left Ventricular Dysfunction
    Open this publication in new window or tab >>Experimental Venoarterial Extracorporeal Membrane Oxygenation Induces Left Ventricular Dysfunction
    2016 (English)In: ASAIO journal (1992), ISSN 1058-2916, E-ISSN 1538-943X, Vol. 62, no 5, p. 518-524Article in journal (Refereed) Published
    Abstract [en]

    Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has experienced an increased use in acute cardiac failure. There are some reports on negative effects of VA-ECMO on cardiac function, such as left ventricular (LV) dilatation and cardiac stun, but the support in the literature is scarce. This study investigates the effects of experimental VA-ECMO on LV function in both peripheral and central cannulation. Ten pigs were randomized to VA-ECMO by either peripheral cannulation through the femoral vessels or central cannulation in the right atrium and ascending aorta. Left ventricular performance was measured with pressure-volume catheters during 5 hours of VA-ECMO. The LV enddiastolic and end-systolic volumes increased comparably in both groups during ECMO. Left ventricular ejection fraction, stroke work, and maximum rate of pressure change decreased comparably in both groups as a function of time on ECMO. The site of cannulation had no impact on the LV response to ECMO. In conclusion, VA-ECMO increased LV volumes and reduced LV function, irrespective of cannulation site in this experimental model. Reduced LV ejection fraction and stroke work indicated LV dysfunction during ECMO.

    Keyword
    extracorporeal membrane oxygenation, cannulation, left ventricle, left ventricular assist device
    National Category
    Cardiac and Cardiovascular Systems
    Identifiers
    urn:nbn:se:uu:diva-310680 (URN)10.1097/MAT.0000000000000392 (DOI)000387874900006 ()27195745 (PubMedID)
    Available from: 2017-01-09 Created: 2016-12-19 Last updated: 2018-04-12Bibliographically approved
    2. Left Ventricular Decompression during Extracorporeal Membrane Oxygenation (ECMO) Treatment does not Reduce Size of Myocardial Infarction in an Experimental Model
    Open this publication in new window or tab >>Left Ventricular Decompression during Extracorporeal Membrane Oxygenation (ECMO) Treatment does not Reduce Size of Myocardial Infarction in an Experimental Model
    (English)Manuscript (preprint) (Other academic)
    National Category
    Cardiac and Cardiovascular Systems
    Identifiers
    urn:nbn:se:uu:diva-347425 (URN)
    Available from: 2018-04-02 Created: 2018-04-02 Last updated: 2018-04-12
    3. The Impella® Recover mechanical assist device in acute cardiogenic shock: a single-centre experience of 66 patients
    Open this publication in new window or tab >>The Impella® Recover mechanical assist device in acute cardiogenic shock: a single-centre experience of 66 patients
    2016 (English)In: Interactive Cardiovascular and Thoracic Surgery, ISSN 1569-9293, E-ISSN 1569-9285, Vol. 22, no 4, p. 452-458Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVES: Short-term ventricular assist devices are more frequently used in patients with acute cardiogenic shock. The aim of this study was to evaluate its effect on haemodynamic parameters, as well as the short- and long-term outcome and complication rate associated with the device. METHODS: All patients treated with the ImpellaA (R) Recover device at our centre from 2003 to 2014 (n = 66) were included in this study, and follow-up time was 2.9 (+/- 0.4) years. Data were obtained through patient records and the population register. Patient-related factors, preimplantation and early postimplantation haemodynamic and biochemical parameters were analysed. Characteristics of survivors and non-survivors were compared. RESULTS: The device was implanted in 66 patients and 58% (38/66) were alive at 30 days post-implantation. The mean duration of support was 7.4 (+/- 0.8) days. Mean time in the intensive care unit was 24 (+/- 4) days. Following device implantation, patients' cardiac index improved from 2.1 l/min/m(2) (+/- 0.20) to 3.8 l/min/m(2) (+/- 0.20) at Day 7, mixed venous saturation increased from 56% (+/- 2.0) to 68% (+/- 1.2) and diuresis increased from 69 ml/h (+/- 9) at device insertion to 105 ml/h (+/- 19) at Day 7 on support. Central venous pressure, lactate levels and inotropic support decreased on support. No difference between survivors and non-survivors was established. No correlation was established between preimplant parameters and 30-day mortality. CONCLUSIONS: The ImpellaA (R) Recover device improved haemodynamics in patients with acute cardiogenic shock. Still, 30-day mortality remains high and future studies must focus on the optimal timing of placement of the device.

    Keyword
    Heart failure, Acute cardiogenic shock, Left ventricular assist device
    National Category
    Cardiac and Cardiovascular Systems
    Identifiers
    urn:nbn:se:uu:diva-296864 (URN)10.1093/icvts/ivv305 (DOI)000374228700013 ()26763043 (PubMedID)
    Available from: 2016-06-20 Created: 2016-06-20 Last updated: 2018-04-12Bibliographically approved
    4. Survival after Refractory Cardiogenic Shock is Comparable in Patients with Impella® and Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO) - when Adjusted for SAVE-score
    Open this publication in new window or tab >>Survival after Refractory Cardiogenic Shock is Comparable in Patients with Impella® and Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO) - when Adjusted for SAVE-score
    (English)Manuscript (preprint) (Other academic)
    National Category
    Cardiac and Cardiovascular Systems
    Identifiers
    urn:nbn:se:uu:diva-347426 (URN)
    Available from: 2018-04-02 Created: 2018-04-02 Last updated: 2018-04-12
  • Matikas, Alexios
    et al.
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Margolin, Sara
    Stockholm South Gen Hosp, Dept Oncol, Stockholm, Sweden..
    Hellström, Mats
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Johansson, Hemming
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Bengtsson, Nils-Olof
    Norrland Univ Hosp, Umea, Sweden..
    Karlsson, Lena
    Cty Hosp, Sundsvall, Sweden..
    Edlund, Per
    Gavle Cent Hosp, Gavle, Sweden..
    Karlsson, Per
    Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Oncol,Inst Clin Sci, Gothenburg, Sweden..
    Lidbrink, Elisabet
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Linderholm, Barbro
    Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Oncol,Inst Clin Sci, Gothenburg, Sweden..
    Lindman, Henrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Malmstrom, Per
    Skane Univ Hosp, Dept Oncol & Radiat Phys, Lund, Sweden..
    Villman, Kenneth
    Orebro Univ Hosp, Orebro, Sweden..
    Foukakis, Theodoros
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Bergh, Jonas
    Karolinska Univ Hosp, Radiumhemmet, Dept Oncol, Stockholm, Sweden..
    Long-term safety and survival outcomes from the Scandinavian Breast Group 2004-1 randomized phase II trial of tailored dose-dense adjuvant chemotherapy for early breast cancer2018In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 168, no 2, p. 349-355Article in journal (Refereed)
    Abstract [en]

    Although adjuvant polychemotherapy improves outcomes for early breast cancer, the significant variability in terms of pharmacokinetics results in differences in efficacy and both short and long-term toxicities. Retrospective studies support the use of dose tailoring according to the hematologic nadirs. The SBG 2004-1 trial was a randomized feasibility phase II study which assessed tailored dose-dense epirubicin and cyclophosphamide (EC) followed by docetaxel (T) (group A), the same regimen with fixed doses (group B) and the TAC regimen (group C). Women aged 18-65 years, ECOG PS 0-1 with at least one positive axillary lymph node were randomized 1:1:1. The primary endpoint of the study was the safety and feasibility of the treatment. Toxicity was graded according to CTC-AE version 3.0. The design and short-term toxicity have been previously published. Here, we report safety and efficacy data after 10 years of follow-up. A total of 124 patients were included in the study. After a median follow-up of 10.3 years, the probability for 10-year survival was 78.5, 75.1, and 63.4% and for relapse free survival 64.1, 71.0, and 59.5% for groups A, B, and C, respectively. There were no cases of clinically diagnosed cardiotoxicity or hematologic malignancies. No patient was lost to follow-up. In this randomized phase II trial, tailored dose adjuvant chemotherapy was feasible, without an increased risk for long-term adverse events after a median follow-up of 10 years.

  • Ekstedt, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction.
    A Deep Reinforcement Learning Framework where Agents Learn a Basic form of Social Movement2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    For social robots to move and behave appropriately in dynamic and complex social contexts they need to be flexible in their movement behaviors. The natural complexity of social interaction makes this a difficult property to encode programmatically. Instead of programming these algorithms by hand it could be preferable to have the system learn these behaviors. In this project a framework is created in which an agent, through deep reinforcement learning, can learn how to mimic poses, here defined as the most basic case of social movements. The framework aimed to be as agent agnostic as possible and suitable for both real life robots and virtual agents through an approach called "dancer in the mirror". The framework utilized a learning algorithm called PPO and trained agents, as a proof of concept, on both a virtual environment for the humanoid robot Pepper and for virtual agents in a physics simulation environment. The framework was meant to be a simple starting point that could be extended to incorporate more and more complex tasks. This project shows that this framework was functional for agents to learn to mimic poses on a simplified environment.

  • Isaksson, Raine
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Taylor, Neil
    Intec Services Pty Ltd.
    Drivers for sustainability: Making better use of cement in Dar es Salaam2009In: International Conference - Quality and Service Sciences 2009, Verona Italy, 2009Conference paper (Refereed)
    Abstract [en]

    Background: The Stern Review asserts that “Policy to reduce emissions should be based on three essential elements: carbon pricing, technology policy, and removal of barriers to behavioural change”. The most demanding challenge could be the issue of behavioural change which requires the mobilization of drivers for change towards more sustainable performance. According to reports from the WBCSD, the building supply chain in many countries could account for as much as 40% of man made carbon emissions. Most building growth is taking place in Third World countries with concrete and especially concrete blocks as the most widely used building material. Cement is the most expensive component of these materials and also has the highest carbon footprint. This means that it is of both economic and environmental interest to see that cement is used in the best way in order to make best use of resources.

    Purpose: To diagnose the improvement potential of a typical building supply network. To identify governance, technology and behavioural barriers to change and to propose how drivers for sustainable change could be strengthened.

    Methodology: A process based system model has been used to identify the main elements in the building supply network used for making concrete blocks in Dar es Salaam, Tanzania. The blockmaking process has been studied in some detail, using process walks at five different blockmaking sites. Additionally interviews with block makers, cement manufacturers and control laboratories for brick measurement have also been used to collect data. The resulting material has been summarised in a single unit multiple case study. The collected material has then been subjected to an opportunity study that covers diagnosis, analysis, and to some extent, proposed actions for improvement. The diagnosis provides the theoretical improvement potential in terms of user value per price and user value per carbon footprint. The analysis of the causes for the improvement potential has been carried out using a checklist for resources with focus on Material, Machine, Method, Measurement, Manpower and Management factors. Proposed actions focus on ideas of how to reinforce drivers that will help to overcome the main identified barriers, which are mainly expressed as resource problems.

    Research limitations: Block-making has been used to exemplify the main building supply network in Dar es Salaam. The justification for this choice is that approximately 60% of cement sales in Dar es Salaam go into block-making. In a typical Western context only 15% of the entire carbon footprint over the lifetime of a building comes from building materials with the rest coming mainly from heating and cooling. The situation in an African city like Dar es Salaam is very different with relatively few buildings having cooling and none having heating. Consequently  the role of the building materials, and especially cement use, becomes more important both in terms of initial cost and for the resulting carbon footprint.  

  • Björktomta, Siv-Britt
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology, Centre for Social Work - CESAR.
    Aarum Hansen, Heidi
    Department of Health and Welfare Studies, Østfold University College, Østfold, Norway.
    Child welfare services and social media: childhood, being and becoming in a digital society2018In: Croatian Medical Journal, ISSN 0353-9504, E-ISSN 1332-8166, ISSN 1332-8166, Vol. 59, no 2, p. 90-92Article in journal (Refereed)
    Abstract [en]

    In the internet arena, children have more space for action. Accordingly, their use of social media challenges the public services. Children´s navigating social media landscapes is an example of a change that calls for new research into the following questions: What do social workers think about contacting children via social media? Can social media be used as a tool in case assessment? And can the internet enable social workers to reach children in difficult life situations?

  • Arjmandi-Tash, Hadi
    et al.
    Leiden Univ, Leiden Inst Chem, Fac Sci, NL-2333 CC Leiden, Netherlands..
    Bellunato, Amedeo
    Leiden Univ, Leiden Inst Chem, Fac Sci, NL-2333 CC Leiden, Netherlands..
    Wen, Chenyu
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Olsthoorn, Rene C.
    Leiden Univ, Leiden Inst Chem, Fac Sci, NL-2333 CC Leiden, Netherlands..
    Scheicher, Ralph H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Zhang, Shi-Li
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Schneider, Gregory F.
    Leiden Univ, Leiden Inst Chem, Fac Sci, NL-2333 CC Leiden, Netherlands..
    Zero-Depth Interfacial Nanopore Capillaries2018In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 9, article id 1703602Article in journal (Refereed)
    Abstract [en]

    High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, nanocapillaries of zero depth are formed by dissolving two superimposed and crossing metallic nanorods, molded in polymeric slabs. In an electrolyte, the interface shared by the crossing fluidic channels is mathematically of zero thickness and defines the narrowest constriction in the stream of ions through the nanopore device. This novel architecture provides the possibility to design nanopore fluidic channels, particularly with a robust 3D architecture maintaining the ultimate zero thickness geometry independently of the thickness of the fluidic channels. With orders of magnitude reduced biomolecule translocation speed, and lowered electronic and ionic noise compared to nanopores in 2D materials, the findings establish interfacial nanopores as a scalable platform for realizing nanofluidic systems, capable of single-molecule detection.

  • Stigbrand, Hampus
    et al.
    Länssjukhuset Gävle, Dept Orthopaed Surg, Gävle, Sweden..
    Gustafsson, Oscar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Department of Orthopaedic Surgery, Sunderby Sjukhus, Luleå, Sweden.
    Ullmark, Gösta
    Länssjukhuset Gävle, Dept Orthopaed Surg, Gävle, Sweden..
    A 2-to 16-Year Clinical Follow-Up of Revision Total Hip Arthroplasty Using a New Acetabular Implant Combined With Impacted Bone Allografts and a Cemented Cup2018In: The Journal of Arthroplasty, ISSN 0883-5403, E-ISSN 1532-8406, Vol. 33, no 3, p. 815-822Article in journal (Refereed)
    Abstract [en]

    Background: Treatment of acetabular bone loss with impaction bone grafting (IBG) at revision total hip arthroplasty is highly dependent on mechanical stability and graft compression for clinical success. Here, we describe a new technique to further compress and stabilize the acetabular graft bed with a thin, perforated titanium shell.

    Methods: We retrospectively analyzed 170 cases of acetabular revision arthroplasty 7 years (standard deviation 2.8) after IBG combined with a graft-compressing titanium shell implant. The patients were reviewed by clinical score and radiography. Three patients were lost to follow-up. The medical journals of the 33 deceased cases were reviewed for any reoperation. Of the 170 cases, 74 had a cavitary acetabular bone defect, 93 had combined segmental and cavitary bone defects, and 3 had a pelvic dissociation. Bone graft incorporation was assessed and correction of the hip center of rotation was calculated. Results: Five cases (3%) were reoperated for mechanical loosening. One more was assessed as loose but asymptomatic and was not planned for revision. There were 3 reoperations for recurrent dislocation, 2 for deep infection and 1 for technical error. Reoperation for any reason, as the end point of survivorship, showed a survival rate of 92% after 10 years. Hip score according to Merle, d'Aubigne, and Postel increased from 10.8 (preoperatively) to 16.4 at follow-up. The clinical and radiological results were excellent.

    Conclusion: IBG combined with the compressing shell results in excellent results for this challenging condition.

  • Sandqvist, Anna
    et al.
    Umea Univ, Clin Pharmacol, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden..
    Schneede, Jörn
    Umea Univ, Clin Pharmacol, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden..
    Kylhammar, David
    Lund Univ, Dept Clin Sci Lund, Cardiol, Lund, Sweden.;Skane Univ Hosp, Sect Heart Failure & Valvular Dis, Lund, Sweden..
    Henrohn, D
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Lundgren, Jakob
    Lund Univ, Dept Clin Sci Lund, Cardiol, Lund, Sweden.;Skane Univ Hosp, Sect Heart Failure & Valvular Dis, Lund, Sweden..
    Hedeland, Mikael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Science. Natl Vet Inst SVA, Dept Chem, Uppsala, Sweden..
    Bondesson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Science. Natl Vet Inst SVA, Dept Chem, Uppsala, Sweden..
    Rådegran, Göran
    Lund Univ, Dept Clin Sci Lund, Cardiol, Lund, Sweden.;Skane Univ Hosp, Sect Heart Failure & Valvular Dis, Lund, Sweden..
    Wikström, Gerhard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden..
    Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction2018In: Heart and Vessels, ISSN 0910-8327, E-ISSN 1615-2573, Vol. 33, no 3, p. 255-263Article in journal (Refereed)
    Abstract [en]

    Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from l-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) in PAH compared to left ventricular systolic dysfunction (LVSD) and healthy subjects. This was an observational, multicenter study comparing 21 patients with PAH to 14 patients with LVSD and 27 healthy subjects. Physical examinations were obtained and blood samples were collected. Plasma levels of ADMA, SDMA, l-arginine, l-ornithine, and l-citrulline were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Plasma levels of ADMA and SDMA were higher, whereas l-arginine and l-arginine/ADMA ratio were lower in PAH patients compared to healthy subjects (p < 0.001). Patients with PAH also had lower levels of l-arginine than patients with LVSD (p < 0.05). l-Arginine correlated to 6 min walking distance (6MWD) (r (s) = 0.58, p = 0.006) and l-arginine/ADMA correlated to WHO functional class (r (s) = -0.46, p = 0.043) in PAH. In conclusion, l-arginine levels were significantly lower in treatment na < ve PAH patients compared to patients with LVSD. Furthermore, l-arginine correlated with 6MWD in PAH. l-arginine may provide useful information in differentiating PAH from LVSD.

  • Sjögren, Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Söt och intelligent: Läromedel i italienska på gymnasieskolan ur ett genusperspektiv2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats har undersökt könsstereotypisering och representationen av kvinnor och män i läromedel i italienska på gymnasieskolan. De analyserade läromedlen till antalet fyra (Prego 1, Ciao 1, Comunicare 1 och Amici 1). De är utgivna av Sveriges största läromedelsförlag och utgår från att läsaren talar svenska (i exempelvis inledningar, grammatikavsnitt, gloslistor och anvisningar).

    Läromedel har i allmänhet ett stort inflytande att forma elevers föreställningar om vad som är kvinnligt och manligt. Den svenska läroplanen för gymnasieskolan fäster stor vikt vid värden om jämställdhet och möjligheten att eleven själv ska få skapa sin identitet utan att vara bunden till traditionella könsmönster.

    Studiens frågeställningar syftar till att utforska synligheten av kvinnor och män, representationen av deras givna yrkesroller och hur karaktärerna framställs utifrån genusstereotyper. Metoden som används är både kvantitativ och kvalitativ för att kunna besvara på uppsatsens frågor på ett lämpligt sätt.

    Resultaten visar att skillnaden mellan manliga och kvinnliga karaktärer vad gäller synlighet är marginell, men männen är alltid i majoritet. Det stämmer även gällande yrken: Män tilldelas fler yrkesroller än kvinnor. Trots det finns det något enstaka normbrytande exempel. Slutligen visar analysen på att läromedlen till en viss del ger uttryck för genusstereotyper. 

  • Karlsson, Emelie
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Malm, Josefine
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Visuella semiotiska resurser: En kvalitativ studie av hur och varför material på klassrumsväggar används av lärare i undervisningen2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den här studien har undersökt visuella semiotiska resurser på klassrumsväggar med utgångspunkt i hur de har introducerats och använts samt vilka anledningar som fanns till att de placerades på väggarna i klassrummen. Centrala begrepp i studien har varit visuella semiotiska resurser, semiotiska resurser samt socialsemiotik. De centrala begreppen i vår studie har definierats i avsnitt 2.2 och 4. Socialsemiotik var förutom ett centralt begrepp även det teoretiska perspektiv som studien hade sin grund i. Den tidigare forskningen som vi har relaterat vår studie till berörde den sociokulturella traditionen, barns minne, andraspråkselever samt elever i behov av särskilt stöd. Kvalitativa intervjuer har använts som metod. Underlaget till studien bestod av insamlade data från fyra lärare i olika årskurser på samma skola. Det visade sig att de visuella semiotiska resurser som undersöktes i studien kunde kategoriseras utifrån tre olika sätt att introducera dessa för eleverna.

    Visuella semiotiska resurser som har introducerats genom att:

    • eleverna själva har fått upptäcka dem
    • de har presenterats för eleverna
    • eleverna har fått arbeta med dem

    Att introducera visuella semiotiska resurser genom att presentera dem för eleverna visade sig vara närmare sammankopplat med en fortsatt aktiv användning av den visuella semiotiska resursen än när något av de andra två introduktionssätten användes. Resultatet visade även att anledningarna till att de visuella semiotiska resurserna sattes upp på klassrumsväggarna var för att dessa skulle fungera som inspiration och motivation, eller för att påminna eleverna om vad som hade gjorts eller vad som förväntades av dem. En slutsats som har dragits av studiens resultat var att samtliga lärare har utgått från deras respektive klasser som helhet när de har satt upp de visuella semiotiska resurserna, som omfattats av studien, på klassrumsväggarna. 

  • Nordin, Alice, Davies, Daniel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Mobbning: ett komplext begrepp, en enkät och intervjustudie2016Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studien som vi har utfört är till för att belysa skillnader i definitionen av begreppet mobbning. Studien har utförts genom en enkätundersökning som gjorts på 179 elever där 10 av de 179 eleverna har blivit intervjuade. Intervjuerna blev en metodstudie då de hade som syfte att fördjupa förståelsen av hur eleverna uppfattade enkäten. Ganska omgående in i arbetsprocessen märkte vi att tidigare forskning inom detta specifika område har varit begränsad. Det har tidigare mestadels fokuserats på anledningar och nya motarbetande strategier istället för begreppets definition. Av den tidigare forskning som dock kan anses vara relevant för vår studie finns en antydan till skillnader i uppfattningen av definitionen beroende på ålder. Den tidigare forskningen (se avsnitt tidigare forskning) belyser också vikten av att definiera begreppet mobbning. I den tidigare forskningen(se avsnitt tidigare forskning) urskiljer vi till största del skillnader från de resultat denna studie visar. Vår studies resultat tyder på att faktorer som återupprepning, intentioner och språkliga kunskaper är de parametrar som är mest avgörande för de olika åldersgruppernas definition av mobbning.    

     

    Nyckelbegreppet som huvudsakligen har använts i skapandet av studien är mobbning. Både i den definition som den tidigare forskningen(Olewus, 1999)(Monks & Smith, 2006)(Naylor, Cowie, Cossin & Fabiennes, 2006)(se tidigare forskning) statliga verksamheter och organisationer (Friends, skolor och Skolverket) har tagit fram, är mobbning det begrepp som är mest naturligt för kontexten. Mobbning är även det begrepp som används flitigast i studien. När begreppet mobbning diskuterats har även begreppets definition använts, som då syftar framförallt till det elever tycker beskriver begreppet mobbning. I definitionerna av mobbning används begrepp som kränkningar, kränkande behandling och exkludering. Det är begrepp som är oundvikliga när ämnet diskuteras.            

  • Larslin, Albin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    IKT och lärande: Ett specialpedagogiskt perspektiv2017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det är ingen hemlighet att den svenska specialpedagogiken i skrivandets stund upplever stora förändringar. Den allt mer digitaliserade svenska skolan skapar möjligheter till särskilda anpassningar som för 10 år sedan specialpedagogerna bara kunde drömma om. Digitala verktyg som datorer och iPads möjliggör helt andra typer av det man kallar för ”särskilt stöd”. Plötsligt kan dyslektiker både läsa och skriva och elever med koncentrationssvårigheter kan arbeta hela lektioner i sträck. Samtidigt så måste ju någon veta hur de kompensatoriska verktygen skall användas för att gynna elevernas lärande. Denna någon måste vara en specialpedagog.

    Trots att en hel del forskning redan gjorts på hur elever påverkas av att arbeta med digitala verktyg så är det tydligt att det i den tidigare forskningen också finns ett stort tomrum: Ingen har frågat sig hur specialpedagogerna upplever att skolans digitalisering påverkat deras profession?

    Denna studie vill försöka bidra till att fylla just detta tomrum. Hur påverkas den specialpedagogiska professionen av skolans digitalisering? Och på vilka sätt förändrar digitaliseringen specialpedagogernas möjligheter att bidra till elevers lärande? Det är dessa frågor studien försöker besvara genom att kvalitativt intervjua sex specialpedagoger om deras upplevelser av digitaliseringen. Explicit kan studiens frågeställningar uttryckas enligt följande:

    • På vilka sätt anser verksamma specialpedagoger att deras yrkesutövning påverkats av digitaliseringen av skolan och användningen av ikt-verktyg i undervisningen?
    • På vilka sätt förändrar digitaliseringen av skolan och användandet av ikt-verktyg i undervisningen verksamma specialpedagogers möjligheter att bidra till elevers lärande och utveckling?

    Studiens resultat visar på stora förändringar inom den specialpedagogiska professionen. Många upplever att yrket fått en mer handledande roll, att det är lättare att individualisera och anpassa undervisningen efter elevernas behov, att kommunikationen på arbetsplatsen förändrats till det bättre och att det är lättare att skapa engagemang kring olika uppgifter med hjälp av ikt-verktyg. Specialpedagogerna har också lyft att man arbetar mer i team kring lever och att det är lättare för all personal på skolan att sätta sig in i en elevs specifika behov. 

  • Erdogdu, Iris
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Milutinovic, Karolina
    Läroböcker i religionskunskap En kvalitativ bild- och innehållsanalys om hur kristendomen och islam framställs i läroböcker för grundskolans första skolår 1-32017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Ganibegovic, Merima
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Sigtuna kommuns grundskolelärares inställning till digitala verktyg i undervisningen.: Med grund i revideringarna gjorda i skolans styrdokument rörande digitalisering2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte är att ta reda på vilken syn Sigtuna kommuns grundskolelärare har på användandet av digitala verktyg i undervisningen. Studiens grund är baserat på de förstärkningar som gjorts i skolans styrdokument rörande digitalisering i skolan. En kvalitativ metod med semistrukturerade intervjuer valdes till denna studie för att få en djupare förståelse för Sigtuna kommuns grundskollärares åsikter kring användandet av digitala verktyg i undervisningen. Det var totalt fyra grundskollärare från Sigtuna kommun som ställde upp och deltog i denna studie. Lärarna som intervjuades arbetade på olika skolor, vilket ledde till en mer övergripande bild. I resultatet framgår det att grundskollärarna i Sigtuna kommun generellt har en positiv inställning till de revideringar som har skett i skolans styrdokument angående digitalisering. Tidigare studier visar att det inte finns några bevis för att digitala verktyg påverkar elevers lärande positivt. Trots detta visar denna studies resultat att grundskolelärare i Sigtuna kommun har en generellt positiv inställning till användningen av digitala verktyg i undervisningen. Samtliga lärare upplevde att de digitala verktygen haft en positiv effekt på elevernas studiemotivation och lärande, samt deras eget arbete som lärare. 

  • Pettersson Walldén, Olivia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kopp, Sarah
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Högre utbildning, behövs det?: - En diskursanalys om högre utbildnings funktion och betydelse i rekryteringsprocessen2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This essay presents a study on the function and meaning of higher education within the context of recruitment. The attention was directed towards how employers perceives the role of higher education in the process of recruiting new staff for human resources and recruitment positions and in particular toward the sense making of the relationship between higher education and the persons supposed to be recruited. The empirical data concocted of six semi- structured interviews with employers from five different recruitments and staffing companies in Stockholm. Theoretically the study draws on Foucault’s work on discourse and power.

    The analysis showed that employers prescribed jobseekers with a higher education degree certain kinds of attributes and personal properties. A person with a higher education was viewed as ambitious, driven, instructive, knowledgeable, analytical and source-critical. On the other hand, a person with a higher education was also connected to less advantageous personal properties and attributes such as being too flexible, difficult to shape, too eager and too development-focused. A higher education was in general considered to be beneficial in the recruitment process but was not always a formal requirement. 

    The role of higher education in the recruitment process was also played in relation to work experience and personality. Higher education was sometimes valued as much as a few years of relevant work experience. However, higher education was considered to be subordinate personality in the recruitment process. How employers view higher education and people with higher education can affect the outcome of the recruitment process in many different ways. Among other things it can be a deceive factor in who that actually gets the position as well as the future career paths of those who already are employed. 

  • Al Rifai, Batoul
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Förskollärarens arbetssätt för att utveckla språket hos flerspråkiga barn2017Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet är att undersöka förskollärarnas arbete för barns språkutveckling inom förskoleverksamheten. Undersökningen utgår ifrån två frågeställningar där den första handlar om vilka strategier förskolläraren använder för att stimulera flerspråkiga barns inlärning av svenska språket. Den andra handlar om på vilket sätt förskolläraren kan använda barns perspektiv för att utveckla svenska språket hos flerspråkiga barn.Undersökningen består av kvalitativa samtalsintervjuer och barnobservationer. Tre förskollärare från två olika förskolor i Uppsala kommun har intervjuats, medan observationerna genomfördes på en förskola och fokus lades på måltids- och samlingsstunder. Resultatet av undersökningen visar att förskolläraren använder matsituationen som ett viktigt tillfälle för att utveckla språket hos flerspråkiga barn och att förskolläraren även använder sig av olika strategier för att främja barns språkutveckling.

  • Thuresson, Markus
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Drinfeld Centers2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Gustafsson, Henrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Sportig flicka eller passiv pojke?: En läromedelsanalys av matematikböcker för årskurs 12018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-06-05 09:15 B21, BMC, Uppsala
    Jonsson, Henrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Confined Compression of Single Particles: Development of a Novel Triaxial Testing Instrument and Particle-Scale Modelling2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    When predicting the performance of a powder compaction process, assessing the behaviour of the particles comprising the powder bed is of central relevance. Currently, however, no experimental methods are available for mimicking the multiaxial loading conditions imposed on the individual particles in a powder bed during compaction, and such analyses are therefore usually performed in silico. Thus, the purpose of this thesis is to introduce a novel experimental method that enables experimental evaluation of confined triaxial loading conditions on individual particles in the mm-scale.

    The work underlying the thesis consists of three major parts. Firstly, the triaxial instrument was designed and developed, after which its performance was evaluated using nominally ideal elastic-plastic spheres as model materials. These initial experiments showed that the instrument was able to successfully impose confined triaxial conditions on the particles, something that was verified by finite element method (FEM) simulations.

    Secondly, the triaxial instrument was used to investigate differences in deformation characteristics under uniaxial and triaxial loading conditions for four different microcrystalline cellulose (MCC)-based granules. It was shown that fragmentation, associated with unconfined uniaxial compression, was impeded under confined triaxial conditions, despite the emergence of cracks. In addition, it was observed that the primary crack always occurs in a plane parallel to the most deformed direction, and that the location of the largest pore has a pronounced influence on the path of the crack.

    Thirdly, the influence of different triaxial loading ratios were evaluated on polymer spheres, after which a unified description of contact pressure development was devised. Data from these experiments were then successfully used to calibrate a contact model for simulating bulk powder compression with the discrete element method (DEM).

    All in all, a novel experimental method has been established, which has proven useful as an alternative and complement to numerical studies when studying single particle deformation under confined triaxial conditions.

    List of papers
    1. An apparatus for confined triaxial testing of single particles
    Open this publication in new window or tab >>An apparatus for confined triaxial testing of single particles
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    2015 (English)In: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 270, p. 121-127Article in journal (Refereed) Published
    Abstract [en]

    A novel triaxial apparatus employing overlapping rigid boundaries has been designed and constructed for experimental measurement of contact forces under confined compression of single granules in the mm-scale. The performance of the apparatus was evaluated by performing uniaxial and triaxial compression experiments on ideal elastic-plastic materials. Compression curves were compared with the fully plastic Abbott-Firestone contact model and with results from FEM simulations. The increase in contact force associated with confined conditions was observed in the compression curves from triaxial compression experiments, as supported by predictions from simulations using single particle contact models. Hence, a new method for the assessment of mechanical behaviour of single particles under confined compression can be considered as established.

    Keyword
    Compression, Triaxial, Single particles, Confined conditions, Apparatus design, Contact mechanics
    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-239203 (URN)10.1016/j.powtec.2014.10.016 (DOI)000347579300014 ()
    Funder
    Swedish Research Council, 621-2011-4049
    Available from: 2014-12-19 Created: 2014-12-19 Last updated: 2018-04-12Bibliographically approved
    2. Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression
    Open this publication in new window or tab >>Investigations of single microcrystalline cellulose-based granules subjected to confined triaxial compression
    2016 (English)In: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 289, p. 79-87Article in journal (Refereed) Published
    Abstract [en]

    Confined triaxial compression of single granules was performed in order to assess the contact force development and modes of granule deformation under these conditions. In the study, four microcrystalline cellulose-based granule types of different characteristics were investigated. Results from triaxial single-granule compression experiments were evaluated using an analytical model as well as by comparison to unconfined single-granule compression and to confined bulk compression experiments. It was observed that single granules deform and densify, but tend to keep their integrity during confined triaxial compression, as evident from both compression data and from morphological analysis. Results from confined single granule compression were well represented by the analytical model. These results also largely reflected those from bulk compression experiments, including features of the force-displacement curves as well as rank order between the granule types in terms of contact stiffness. Furthermore, it was shown that intragranular porosity to a high extent governs the onset of plastic incompressibility.

    Keyword
    Compression, Triaxial, Hydrostatic, Single granules, Confined conditions, Contact mechanics
    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-280895 (URN)10.1016/j.powtec.2015.11.051 (DOI)000370095400012 ()
    Funder
    Swedish Research Council, 621-2011-4049
    Available from: 2016-03-16 Created: 2016-03-16 Last updated: 2018-04-12Bibliographically approved
    3. Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions
    Open this publication in new window or tab >>Mechanical behaviour of ideal elastic-plastic particles subjected to different triaxial loading conditions
    2017 (English)In: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 315, p. 347-355Article in journal (Refereed) Published
    Abstract [en]

    The contact force development for two types of polymeric elastoplastic particles subjected to different triaxial loading conditions was studied experimentally utilising a unique triaxial testing apparatus. In order to evaluate the experimental results, a finite element analysis was performed. The experimental findings highlighted the importance of contact dependence, which manifested itself in two principally different ways. Firstly, a reduced stiffness was observed when plastic deformation ceased to be fully contained, which, depending on the loading conditions, occurred at an engineering strain of about 5-10%. Secondly, a markedly increased stiffness was observed when particle confinement inhibited further plastic deformation, making elastic volume reduction the predominant deformation mode. The experimental results could be well reproduced by the numerical simulations, provided that isotropic hardening was included in the elastoplastic model. In an attempt to invariantly describe the data, a nominal contact pressure was determined as a function of the volumetric constraint of the particle. This resulted in an adequate collapse of results obtained for different loading conditions onto a single master curve at large volumetric constraint. In summary, this paper should be considered as a step along the pathway towards our long term goal of introducing novel and improved contact models.

    Keyword
    Particle mechanics, Triaxial, Compression, Spatial confinement, Contact dependence
    National Category
    Applied Mechanics
    Identifiers
    urn:nbn:se:uu:diva-323755 (URN)10.1016/j.powtec.2017.04.005 (DOI)000401593600041 ()
    Funder
    Swedish Research Council, 621-2011-4049
    Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2018-04-12Bibliographically approved
    4. Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load
    Open this publication in new window or tab >>Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Cracking patterns of four kinds of granules, based on the common pharmaceutical excipient microcrystalline cellulose (MCC) and subject to compressive load, were examined. The initial pore structure and the location of initial failure under uniaxial compression were assessed using X-ray micro-computed tomography, whereas contact force development and onset of cracking under more complex compressive load were examined using a triaxial testing apparatus. Smoothed particle hydrodynamics (SPH) simulations were employed for numerical analysis of the stress distributions prior to cracking. For granules subject to uniaxial compression, initial cracking always occurred along the meridian and the precise location of the crack depended on the pore structure. Likewise, for granules subject to triaxial compression, the fracture plane of the primary crack was generally parallel to the dominant loading direction. The occurrence of cracking was highly dependent on the triaxiality ratio, i.e. the ratio between the punch displacements in the secondary and dominant loading directions. Compressive stresses in the lateral directions, induced by triaxial compression, prevented crack opening and fragmentation of the granule, something that could be verified in the SPH simulations. These results provide corroboration as well as further insights into previously observed differences between confined and unconfined compression of granular media.

    National Category
    Pharmaceutical Sciences
    Research subject
    Pharmaceutics
    Identifiers
    urn:nbn:se:uu:diva-347457 (URN)
    Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-04-12
    5. Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles
    Open this publication in new window or tab >>Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Confined compression of bimodal mixtures of ideal spherical cellulose acetate (CA) particles (diameters 1.5 and 2.0 mm) was studied numerically with the discrete element method (DEM) and experimentally using a materials tester equipped with suitable tablet tooling. An extended truncated sphere contact model was used in the simulations, enabling them to be carried out to high relative densities (approaching and sometimes exceeding unity). In order to calibrate this model, the contact pressure development was extracted from prior experimental investigations on single 2.0-mm large CA particles. Results from the simulations were evaluated with the Kawakita and Heckel compression equations and compared to the corresponding data obtained from bulk compression experiments. Generally, a high degree of similarity between experiments and simulations was observed, showing the usefulness of combining confined single particle compression experiments with a suitable numerical model when predicting the performance of powder compression to high relative densities.

    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-347458 (URN)
    Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-04-12
  • Eriksson Baaz, Maria
    et al.
    School of Global Studies, University of Gothenburg, Gothenburg, Sweden.
    Stern, Maria
    School of Global Studies, University of Gothenburg, Gothenburg, Sweden.
    Curious erasures: The sexual in wartime sexual violence2018In: International feminist journal of politics, ISSN 1461-6742, E-ISSN 1468-4470Article in journal (Refereed)
    Abstract [en]

    Wartime sexual violence is especially egregious precisely because it is a sexualform of violence that causes particular harms. Yet, curiously, and in contrast to feminist theory on sexual violence more generally, the sexual has been erased from frames of understanding in dominant accounts of wartime rape. This article places the seeming certainty that “wartime rape is not about sex (it’s about power/violence)” under critical scrutiny and poses questions about the stakes of the erasure of the sexual in explanations of conflict-related sexual violence. It argues that the particular urgency that accompanies this erasure reflects the workings of familiar distinctions between war and peace, as well as efforts to clearly recognize violence and separate it from sex. Erasing the sexual from accounts of wartime rape thus ultimately reinscribes the normal and the exceptional as separate, and reproduces a reductive notion of heterosexual masculine sex (in peacetime) that is ontologically different from the violence of war.

  • Public defence: 2018-06-08 09:00 Rudbecksalen, Rudbecklaboratoriet, Uppsala
    Djureinovic, Dijana
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Transcriptomic and Proteomic Analysis of Tumor Markers in Tissue and Blood from Patients with Lung Cancer2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Despite recent treatment advancements, the survival outcome remains poor for the majority of patients with non-small cell lung cancer (NSCLC). The aim of this thesis was to evaluate protein expression to predict prognosis and identify biomarkers that can be used as targets for immunotherapy or for early detection of NSCLC.

    In Paper I an optimized immunohistochemistry (IHC)-based prognostic model was developed for NSCLC. The prognostic performance of the model was compared to the clinicopathological parameters that are used in the clinical setting to predict outcome. The protein model failed to outperform clinicopathological parameters in predicting survival outcome questioning the potential of IHC-based assessment of prognostic markers in NSCLC.

    In Paper II the human testis-specific proteome was profiled using RNA-sequencing (RNA-seq) data from testis and 26 other organs. More than 1000 genes demonstrated a testis-enriched expression pattern which makes testis the tissue with the most tissue-specific genes. The majority of the testis-enriched genes were previously poorly described and were further profiled by IHC. This analysis provides a starting point to increase the molecular understanding of testicular biology.

    In Paper III the profiling of cancer-testis antigens (CTAs) was performed in NSCLC by using RNA-seq data from 32 normal organs and NSCLC. Ninety genes showed CTA expression profiles. The transcriptomic data were validated by IHC for several CTAs. The comprehensive analysis of CTAs can guide biomarker studies or help to identify targets for immunotherapeutic strategies.

    In Paper IV the reactivity of CTAs was evaluated by measuring the abundance of autoantibodies in plasma from patients with NSCLC and benign lung diseases. Twenty-nine CTAs demonstrated exclusive reactivity in NSCLC and six of them were reactive in an independent NSCLC cohort. These findings suggest that some CTAs are immunogenic and could be utilized in immunotherapy.

    In Paper V an immunoassay was used on lung adenocarcinoma plasma samples and samples from benign lung diseases. The plasma levels of 92 cancer related proteins were used to build a model that discriminated lung adenocarcinoma from benign controls with a sensitivity of 93% and a specificity of 64%. The results indicate that this assay is promising for the early detection of NSCLC.

    In summary, this thesis presents an integrative analysis of lung cancer tissue and blood samples to characterize NSCLC on the transcriptomic and proteomic level and to identify cancer specific proteins.

    List of papers
    1. Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
    Open this publication in new window or tab >>Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
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    2017 (English)In: Modern Pathology, ISSN 0893-3952, E-ISSN 1530-0285, Vol. 30, no 7, p. 964-977Article in journal (Refereed) Published
    Abstract [en]

    Numerous protein biomarkers have been analyzed to improve prognostication in non-small cell lung cancer, but have not yet demonstrated sufficient value to be introduced into clinical practice. Here, we aimed to develop and validate a prognostic model for surgically resected non-small cell lung cancer. A biomarker panel was selected based on (1) prognostic association in published literature, (2) prognostic association in gene expression data sets, (3) availability of reliable antibodies, and (4) representation of diverse biological processes. The five selected proteins (MKI67, EZH2, SLC2A1, CADM1, and NKX2-1 alias TTF1) were analyzed by immunohistochemistry on tissue microarrays including tissue from 326 non-small cell lung cancer patients. One score was obtained for each tumor and each protein. The scores were combined, with or without the inclusion of clinical parameters, and the best prognostic model was defined according to the corresponding concordance index (C-index). The best-performing model was subsequently validated in an independent cohort consisting of tissue from 345 non-small cell lung cancer patients. The model based only on protein expression did not perform better compared to clinicopathological parameters, whereas combining protein expression with clinicopathological data resulted in a slightly better prognostic performance (C-index: all non-small cell lung cancer 0.63 vs 0.64; adenocarcinoma: 0.66 vs 0.70, squamous cell carcinoma: 0.57 vs 0.56). However, this modest effect did not translate into a significantly improved accuracy of survival prediction. The combination of a prognostic biomarker panel with clinicopathological parameters did not improve survival prediction in non-small cell lung cancer, questioning the potential of immunohistochemistry-based assessment of protein biomarkers for prognostication in clinical practice.Modern Pathology advance online publication, 10 March 2017; doi:10.1038/modpathol.2017.14.

    National Category
    Cancer and Oncology Medical Genetics
    Identifiers
    urn:nbn:se:uu:diva-318128 (URN)10.1038/modpathol.2017.14 (DOI)000404718100006 ()28281552 (PubMedID)
    Funder
    Swedish Cancer Society
    Available from: 2017-03-23 Created: 2017-03-23 Last updated: 2018-04-11Bibliographically approved
    2. The human testis-specific proteome defined by transcriptomics and antibody-based profiling
    Open this publication in new window or tab >>The human testis-specific proteome defined by transcriptomics and antibody-based profiling
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    2014 (English)In: Molecular human reproduction, ISSN 1360-9947, E-ISSN 1460-2407, Vol. 20, no 6, p. 476-488Article in journal (Refereed) Published
    Abstract [en]

    The testis' function is to produce haploid germ cells necessary for reproduction. Here we have combined a genome-wide transcriptomics analysis with immunohistochemistry-based protein profiling to characterize the molecular components of the testis. Deep sequencing (RNA-Seq) of normal human testicular tissue from seven individuals was performed and compared with 26 other normal human tissue types. All 20 050 putative human genes were classified into categories based on expression patterns. The analysis shows that testis is the tissue with the most tissue-specific genes by far. More than 1000 genes show a testis-enriched expression pattern in testis when compared with all other analyzed tissues. Highly testis enriched genes were further characterized with respect to protein localization within the testis, such as spermatogonia, spermatocytes, spermatids, sperm, Sertoli cells and Leydig cells. Here we present an immunohistochemistry-based analysis, showing the localization of corresponding proteins in different cell types and various stages of spermatogenesis, for 62 genes expressed at > 50-fold higher levels in testis when compared with other tissues. A large fraction of these genes were unexpectedly expressed in early stages of spermatogenesis. In conclusion, we have applied a genome-wide analysis to identify the human testis-specific proteome using transcriptomics and antibody-based protein profiling, providing lists of genes expressed in a tissue-enriched manner in the testis. The majority of these genes and proteins were previously poorly characterised in terms of localization and function, and our list provides an important starting point to increase our molecular understanding of human reproductive biology and disease.

    Keyword
    immunohistochemistry, RNA sequencing, spermatogenesis, testis, tissue specificity
    National Category
    Evolutionary Biology
    Identifiers
    urn:nbn:se:uu:diva-227710 (URN)10.1093/molehr/gau018 (DOI)000336495100002 ()
    Available from: 2014-07-01 Created: 2014-06-30 Last updated: 2018-04-11Bibliographically approved
    3. Profiling cancer testis antigens in non-small-cell lung cancer
    Open this publication in new window or tab >>Profiling cancer testis antigens in non-small-cell lung cancer
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    2016 (English)In: JCI INSIGHT, ISSN 2379-3708, Vol. 1, no 10, article id e86837Article in journal (Refereed) Published
    Abstract [en]

    Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small-cell lung cancer (NSCLC), we compared RNAseq data from 199 NSCLC tissues to the normal transcriptome of 142 samples from 32 different normal organs. Of 232 CTAs currently annotated in the Caner Testis Database (CTdatabase), 96 were confirmed in NSCLC. To obtain an unbiased CTA profile of NSCLC, we applied stringent criteria on our RNAseq data set and defined 90 genes as CTAs, of which 55 genes were not annotated in the CTdatabase, thus representing potential new CTAs. Cluster analysis revealed that CTA expression is histology dependent and concurrent expression is common. IHC confirmed tissue-specific protein expression of selected new CTAs (TKTL1, TGIF2LX, VCX, and CXORF67). Furthermore, methylation was identified as a regulatory mechanism of CTA expression based on independent data from The Cancer Genome Atlas. The proposed prognostic impact of CTAs in lung cancer was not confirmed, neither in our RNAseq cohort nor in an independent meta-analysis of 1,117 NSCLC cases. In summary, we defined a set of 90 reliable CTAs, including information on protein expression, methylation, and survival association. The detailed RNAseq catalog can guide biomarker studies and efforts to identify targets for immunotherapeutic strategies.

    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:uu:diva-310039 (URN)10.1172/jci.insight.86837 (DOI)000387113300012 ()27699219 (PubMedID)
    Available from: 2016-12-09 Created: 2016-12-09 Last updated: 2018-04-11Bibliographically approved
    4. Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer
    Open this publication in new window or tab >>Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Cancer testis antigens (CTAs) are defined as proteins that are specifically expressed in testis or placenta and their expression is frequently activated in cancer. Due to their ability to induce an immune response, CTAs may serve as suitable targets for immunotherapy. The aim of this study was to evaluate if there is reactivity against CTAs in the plasma of non-small cell lung cancer (NSCLC) patients through the detection of circulating antibodies. 

    To comprehensively analyse auto-antibodies against CTAs the multiplexing capacities of suspension bead array technology was used. Bead arrays were created with 120 protein fragments, representing 112 CTAs. Reactivity profiles were measured in plasma samples from 133 NSCLC patients and 57 cases with benign lung diseases. Altogether reactivity against 69 antigens, representing 81 CTAs, was demonstrated in at least one of the analysed samples. Twenty-nine of the antigens (45 CTAs) demonstrated exclusive reactivity in NSCLC samples. Reactivity against CT47A genes, PAGE3, VCX, MAGEB1, LIN28B and C12orf54 were only found in NSCLC patients at a frequency of 1%-4%. The presence of autoantibodies towards these six antigens was confirmed in an independent group of 34 NSCLC patients.

    In conclusion, we identified autoantibodies against CTAs in the plasma of lung cancer patients. The reactivity pattern of autoantibodies was higher in cancer patients compared to the benign group, stable over time, but low in frequency of occurrence. The findings suggest that some CTAs are immunogenic and that these properties can be utilized as immune targets.

    Keyword
    Lung cancer, adenocarcinoma, squamous cell cancer, cancer immunity, tumor markers, MAGE, PAGE
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-347809 (URN)
    Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2018-04-11
    5. Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
    Open this publication in new window or tab >>Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background:The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that detect NSCLC patients at early stages of the disease are of high clinical relevance. The aim of this study was to identify and validate novel protein markers in plasma using the highly sensitive DNA-assisted multiplex proximity extension assay (PEA) to discriminate NSCLC from other lung diseases. 

    Methods:Plasma samples were collected from a total of 343 patients who underwent surgical resection for different lung diseases, including 144 patients with lung adenocarcinoma (LAC),68 patients with non-malignant lung disease, 83 with lung metastasis of colorectal cancers and 48 patients with typical carcinoid. One microliter of plasma was analyzed using PEA, allowing detection and quantification of 92 established cancer related proteins. The concentrations of the plasma proteins were compared between disease groups.

    Results:The comparison between LAC and benign samples revealed significantly different plasma levels for four proteins; CXL17, CEACAM5, VEGFR2 and ERBB3 (adjusted p-value < 0.05). A multi-parameter classifier was developed to discriminate between samples from LAC patients and from patients with non-malignant lung conditions. With a bootstrap aggregated decision tree algorithm (TreeBagger) a sensitivity of 93% and specificity of 64% was achieved to detect LAC in this risk population. 

    Conclusion:By applying the highly sensitive PEA, reliable protein profiles could be determined in microliter amounts of plasma. We further identified proteins that demonstrated different plasma concentration in defined disease groups and developed a signature that holds potential to be included in a screening assay for early lung cancer detection. 

    Keyword
    lung cancer, tumor markers, blood, serum, screening, biomarker
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-347805 (URN)
    Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2018-04-11
  • Axel, Lindegren
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computing Science.
    Partitioning temporal networks: A study of finding the optimal partition of temporal networks using community detection2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Many of the algorithms used for community detection in temporal networks have been adapted from static network theory. A common approach in dealing with the temporal dimension is to create multiple static networks from one temporal, based on a time condition. In this thesis, focus lies on identifying the optimal partitioning of a few temporal networks. This is done by utilizing the popular community detection algorithm called Generalized Louvain. Output of the Generalized Louvain comes in two parts. First, the created community structure, i.e. how the network is connected. Secondly, a measure called modularity, which is a scalar value representing the quality of the identified community structure. The methodology used is aimed at creating a comparable result by normalizing modularity. The normalization process can be explained in two major steps: 1) study the effects on modularity when partitioning a temporal network in an increasing number of slices. 2) study the effects on modularity when varying the number of connections (edges) in each time slice. The results show that the created methodology yields comparable results on two out of the four here tested temporal networks, implying that it might be more suited for some networks than others. This can serve as an indication that there does not exist a general model for community detection in temporal networks. Instead, the type of network is key to choosing the method.

  • Karlsson, Mattias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Egypt between Kush and Assyria: The Perspective of Tanutamani, King of Kush2018Book (Other academic)
  • Jansson, David
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Deadly exceptionalisms, or, would you rather be crushed by a moral superpower or a military superpower?2018In: Political Geography, ISSN 0962-6298, E-ISSN 1873-5096, Vol. 64, p. 83-91Article in journal (Refereed)
    Abstract [en]

    In this essay, I consider the ways in which nationalism in both the U.S. and Sweden relies on notions of exceptionalism, and I discuss what this means materially for their own populations and for the world. The analysis consists of two lines of attack against both these assumptions of exceptionalism – one focusing on psychological processes and the other political economy processes. I examine the historical development of the ideas of U.S. and Swedish exceptionalism, and consider the roles of ignorance, denial, and projection in maintaining these problematic ideas. Through the use of a materialist definition of racism, I show how the nationalist ideology of exceptionalism in these two cases harms the well-being of their own citizens as well as citizens of other states. I argue that a combination of the psychological and political economy approaches are necessary if we are to both understand the power and impact of exceptionalism as a nationalist ideology and to be able to effectively work against their tendency to “crush” marginalized groups.

  • Matt, C. E.
    et al.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.;Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland..
    Sutter, D.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Cook, A. M.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Sassa, Yasmine
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Mansson, M.
    KTH Royal Inst Technol, Mat Phys, SE-16440 Stockholm, Sweden..
    Tjernberg, O.
    KTH Royal Inst Technol, Mat Phys, SE-16440 Stockholm, Sweden..
    Das, L.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Horio, M.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Destraz, D.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Fatuzzo, C. G.
    Ecole Polytech Fed Lausanne, Inst Phys, CH-1015 Lausanne, Switzerland..
    Hauser, K.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Shi, M.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland..
    Kobayashi, M.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland..
    Strocov, V. N.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland..
    Schmitt, T.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland..
    Dudin, P.
    Diamond Light Source, Harwell Campus, Didcot OX11 0DE, Oxon, England..
    Hoesch, M.
    Diamond Light Source, Harwell Campus, Didcot OX11 0DE, Oxon, England..
    Pyon, S.
    Univ Tokyo, Dept Adv Mat, Kashiwa, Chiba 2778561, Japan..
    Takayama, T.
    Univ Tokyo, Dept Adv Mat, Kashiwa, Chiba 2778561, Japan..
    Takagi, H.
    Univ Tokyo, Dept Adv Mat, Kashiwa, Chiba 2778561, Japan..
    Lipscombe, O. J.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England..
    Hayden, S. M.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England..
    Kurosawa, T.
    Hokkaido Univ, Dept Phys, Sapporo, Hokkaido 0600810, Japan..
    Momono, N.
    Hokkaido Univ, Dept Phys, Sapporo, Hokkaido 0600810, Japan.;Muroran Inst Technol, Dept Appl Sci, Muroran, Hokkaido 0508585, Japan..
    Oda, M.
    Hokkaido Univ, Dept Phys, Sapporo, Hokkaido 0600810, Japan..
    Neupert, T.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Chang, J.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Direct observation of orbital hybridisation in a cuprate superconductor2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 972Article in journal (Refereed)
    Abstract [en]

    The minimal ingredients to explain the essential physics of layered copper-oxide (cuprates) materials remains heavily debated. Effective low-energy single-band models of the copper-oxygen orbitals are widely used because there exists no strong experimental evidence supporting multi-band structures. Here, we report angle-resolved photoelectron spectroscopy experiments on La-based cuprates that provide direct observation of a two-band structure. This electronic structure, qualitatively consistent with density functional theory, is parametrised by a two-orbital (d(x2-y2) and d(z2)) tight-binding model. We quantify the orbital hybridisation which provides an explanation for the Fermi surface topology and the proximity of the van-Hove singularity to the Fermi level. Our analysis leads to a unification of electronic hopping parameters for single-layer cuprates and we conclude that hybridisation, restraining d-wave pairing, is an important optimisation element for superconductivity.

  • Reza, Salim H.
    et al.
    Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Uppsala BioCtr, Dept Plant Biol, Uppsala, Sweden.;Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Uppsala BioCtr, Dept Mol Sci, Uppsala, Sweden..
    Delhomme, Nicolas
    Swedish Univ Agr Sci, Dept Forest Genet & Plant Physiol, Umea Plant Sci Ctr, Umea, Sweden..
    Street, Nathaniel R.
    Umea Univ, Dept Plant Physiol, Umea Plant Sci Ctr, Umea, Sweden..
    Ramachandran, Prashanth
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Physiological Botany.
    Dalman, Kerstin
    Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Uppsala BioCtr, Dept Mol Sci, Uppsala, Sweden..
    Nilsson, Ove
    Swedish Univ Agr Sci, Dept Forest Genet & Plant Physiol, Umea Plant Sci Ctr, Umea, Sweden..
    Minina, Elena A.
    Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Uppsala BioCtr, Dept Mol Sci, Uppsala, Sweden..
    Bozhkov, Peter V.
    Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Uppsala BioCtr, Dept Mol Sci, Uppsala, Sweden..
    Transcriptome analysis of embryonic domains in Norway spruce reveals potential regulators of suspensor cell death2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 3, article id e0192945Article in journal (Refereed)
    Abstract [en]

    The terminal differentiation and elimination of the embryo-suspensor is the earliest manifestation of programmed cell death (PCD) during plant ontogenesis. Molecular regulation of suspensor PCD remains poorly understood. Norway spruce (Picea abies) embryos provide a powerful model for studying embryo development because of their large size, sequenced genome, and the possibility to obtain a large number of embryos at a specific developmental stage through somatic embryogenesis. Here, we have carried out global gene expression analysis of the Norway spruce embryo-suspensor versus embryonal mass (a gymnosperm analogue of embryo proper) using RNA sequencing. We have identified that suspensors have enhanced expression of the NAC domain-containing transcription factors, XND1 and ANAC075, previously shown to be involved in the initiation of developmental PCD in Arabidiopsis. The analysis has also revealed enhanced expression of Norway spruce homologues of the known executioners of both developmental and stress-induced cell deaths, such as metacaspase 9 (MC9), cysteine endopeptidase-1 (CEP1) and ribonuclease 3 (RNS3). Interestingly, a spruce homologue of bax inhibitor-1 (PaBI-1, for Picea abies BI-1), an evolutionarily conserved cell death suppressor, was likewise up-regulated in the embryosuspensor. Since Arabidopsis BI-1 so far has been implicated only in the endoplasmic reticulum (ER)-stress induced cell death, we investigated its role in embryogenesis and suspensor PCD using RNA interference (RNAi). We have found that PaBI-1-deficient lines formed a large number of abnormal embryos with suppressed suspensor elongation and disturbed polarity. Cytochemical staining of suspensor cells has revealed that PaBI-1 deficiency suppresses vacuolar cell death and induces necrotic type of cell death previously shown to compromise embryo development. This study demonstrates that a large number of cell-death components are conserved between angiosperms and gymnosperms and establishes a new role for BI-1 in the progression of vacuolar cell death.

  • Negi, Devendra Singh
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Idrobo, Juan Carlos
    Ctr Nanophase Mat Sci, Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA..
    Rusz, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Probing the localization of magnetic dichroism by atomic-size astigmatic and vortex electron beams2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 4019Article in journal (Refereed)
    Abstract [en]

    We report localization of a magnetic dichroic signal on atomic columns in electron magnetic circular dichroism ( EMCD), probed by beam distorted by four-fold astigmatism and electron vortex beam. With astigmatic probe, magnetic signal to noise ratio can be enhanced by blocking the intensity from the central part of probe. However, the simulations show that for atomic resolution magnetic measurements, vortex beam is a more effective probe, with much higher magnetic signal to noise ratio. For all considered beam shapes, the optimal SNR constrains the signal detection at low collection angles of approximately 6-8 mrad. Irrespective of the material thickness, the magnetic signal remains strongly localized within the probed atomic column with vortex beam, whereas for astigmatic probes, the magnetic signal originates mostly from the nearest neighbor atomic columns. Due to excellent signal localization at probing individual atomic columns, vortex beams are predicted to be a strong candidate for studying the crystal site specific magnetic properties, magnetic properties at interfaces, or magnetism arising from individual atomic impurities.

  • Knoll, Fabien
    et al.
    ARAID Fdn Conjunto Paleontol Teruel Dinopolis, Teruel 44002, Spain.;Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Chiappe, Luis M.
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden..
    Sanchez, Sophie
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology. European Synchrotron Radiat Facil, F-38000 Grenoble, France..
    Garwood, Russell J.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;Nat Hist Museum, Dept Earth Sci, Cromwell Rd, London SW7 5BD, England..
    Edwards, Nicholas P.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;SLAC Natl Accelerator Lab, Stanford Synchrotron Radiat Lightsource, Menlo Pk, CA 94025 USA..
    Wogelius, Roy A.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Sellers, William I.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England..
    Manning, Phillip L.
    Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England.;Coll Charleston, Dept Geol & Environm Geosci, Charleston, SC 29424 USA..
    Ortega, Francisco
    Univ Nacl Educ Distancia, Fac Ciencias, E-28040 Madrid, Spain..
    Serrano, Francisco J.
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden.;Univ Malaga, Fac Ciencias, Malaga 29010, Spain..
    Marugan-Lobon, Jesus
    Nat Hist Museum Los Angeles Cty, Dinosaur Inst, Los Angeles, CA 90007 USA. Uppsala Univ, Dept Organismal Biol, S-75236 Uppsala, Sweden.;Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    Cuesta, Elena
    Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    Escaso, Fernando
    Univ Nacl Educ Distancia, Fac Ciencias, E-28040 Madrid, Spain..
    Luis Sanz, Jose
    Univ Autonoma Madrid, Fac Ciencias, E-28049 Madrid, Spain..
    A diminutive perinate European Enantiornithes reveals an asynchronous ossification pattern in early birds2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 937Article in journal (Refereed)
    Abstract [en]

    Fossils of juvenile Mesozoic birds provide insight into the early evolution of avian development, however such fossils are rare. The analysis of the ossification sequence in these early-branching birds has the potential to address important questions about their comparative developmental biology and to help understand their morphological evolution and ecological differentiation. Here we report on an early juvenile enantiornithine specimen from the Early Cretaceous of Europe, which sheds new light on the osteogenesis in this most species-rich clade of Mesozoic birds. Consisting of a nearly complete skeleton, it is amongst the smallest known Mesozoic avian fossils representing post-hatching stages of development. Comparisons between this new specimen and other known early juvenile enantiornithines support a clade-wide asynchronous pattern of osteogenesis in the sternum and the vertebral column, and strongly indicate that the hatchlings of these phylogenetically basal birds varied greatly in size and tempo of skeletal maturation.

  • Ledesma, Jose L. J.
    et al.
    Swedish Univ Agr Sci SLU, Dept Aquat Sci & Assessment, POB 7050, S-75007 Uppsala, Sweden..
    Futter, Martyn N.
    Swedish Univ Agr Sci SLU, Dept Aquat Sci & Assessment, POB 7050, S-75007 Uppsala, Sweden..
    Blackburn, M.
    Swedish Univ Agr Sci SLU, Dept Forest Ecol & Management, Umea, Sweden..
    Lidman, Fredrik
    Swedish Univ Agr Sci SLU, Dept Forest Ecol & Management, Umea, Sweden..
    Grabs, T.homas J.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Sponseller, Ryan A.
    Umea Univ, Dept Ecol & Environm Sci, Uppsala, Sweden..
    Laudon, Hjalmar
    Swedish Univ Agr Sci SLU, Dept Forest Ecol & Management, Umea, Sweden..
    Bishop, Kevin H.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Swedish Univ Agr Sci SLU, Dept Aquat Sci & Assessment, POB 7050, S-75007 Uppsala, Sweden.
    Köhler, Stephan J.
    Swedish Univ Agr Sci SLU, Dept Aquat Sci & Assessment, POB 7050, S-75007 Uppsala, Sweden..
    Towards an Improved Conceptualization of Riparian Zones in Boreal Forest Headwaters2018In: Ecosystems (New York. Print), ISSN 1432-9840, E-ISSN 1435-0629, Vol. 21, no 2, p. 297-315Article in journal (Refereed)
    Abstract [en]

    The boreal ecoregion supports about one-third of the world's forest. Over 90% of boreal forest streams are found in headwaters, where terrestrial-aquatic interfaces are dominated by organic matter (OM)-rich riparian zones (RZs). Because these transition zones are key features controlling catchment biogeochemistry, appropriate RZ conceptualizations are needed to sustainably manage surface water quality in the face of a changing climate and increased demands for forest biomass. Here we present a simple, yet comprehensive, conceptualization of RZ function based on hydrological connectivity, biogeochemical processes, and spatial heterogeneity. We consider four dimensions of hydrological connectivity: (1) laterally along hillslopes, (2) longitudinally along the stream, (3) vertically down the riparian profile, and (4) temporally through event-based and seasonal changes in hydrology. Of particular importance is the vertical dimension, characterized by a 'Dominant Source Layer' that has the highest contribution to solute and water fluxes to streams. In addition to serving as the primary source of OM to boreal streams, RZs shape water chemistry through two sets of OM-dependent biogeochemical processes: (1) transport and retention of OM-associated material and (2) redox-mediated transformations controlled by RZ water residence time and availability of labile OM. These processes can lead to both retention and release of pollutants. Variations in width, hydrological connectivity, and OM storage drive spatial heterogeneity in RZ biogeochemical function. This conceptualization provides a useful theoretical framework for environmental scientists and ecologically sustainable and economically effective forest management in the boreal region and elsewhere, where forest headwaters are dominated by low-gradient, OM-rich RZs.

  • Duraeus, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de rarefactione aëris in antlia pnevmatica. Qvam, ex consensu ampliss. facult. philos. ad regium lyceum Upsal. moderante ... Samuele Duræo ... in audit. Gustaviano die IX. Junii, anno MDCCLXIV. h. a. m. s. publicæ bonorum censuræ submittit Daniel Hallencreutz.1764Dissertation (older thesis) (Other academic)
  • Duraeus, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de impedimentis philosophiæ naturalis, quam consent. ampliss. senatu philosophico, moderante ... mag. Samuele Duræo ... in illustri ad Salam athenæo et audit. Carol. maj. d. 8 junii 1764. pro laurea obtinenda, publico examini offer [sic] Gideon Herm. de Rogier, O. Gothus.1764Dissertation (older thesis) (Other academic)
  • Duraeus, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historico physica eaqve gradualis, de casu, inventorum fertilissimo. Quam, suffragio ampliss. facult. philos. in illustri academia Upsaliensi, præside, mag. Samuele Duræo ... publico examini modeste subjicit stipendiarius Piperianus Olavus Meurling. Pet. fil. Ostro-Gothus in audit. Gustaviano d. 11 juni. anni MDCCLXIV. H. a. m. s.1764Dissertation (older thesis) (Other academic)
  • Duraeus, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio physica, de elasticitate aquæ, qvam consent. ampliss. fac. philosoph. in regia academia Upsaliensi, præside mag. Samuele Duræo ... publico examini modeste defert pro gradu, Carolus Petr. Fernberg, Westmannus. In audit. Gustav. maj. die XXVI. Maj. anni MDCCLXIV. H. a. m. s.1764Dissertation (older thesis) (Other academic)