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  • Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Noden med ansvar för utbildnings- och kompetensfrågor i det nationella nätverket för vindbruk.
    Barney, Andrew
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Engberg Ekman, Marita
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Ny och pågående vindkraftsforskning i Sverige 20132014Report (Other (popular science, discussion, etc.))
  • Cassia, Luca
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Lodin, Rebecca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Popolitov, Aleksandr
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Moscow Inst Phys & Technol, Dolgoprudnyi, Russia;ITEP, Moscow 117218, Russia;Inst Informat Transmiss Problems, Moscow 127994, Russia.
    Zabzine, Maxim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Exact SUSY Wilson loops on S-3 from q-Virasoro constraints2019In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 121Article in journal (Refereed)
    Abstract [en]

    Using the ideas from the BPS/CFT correspondence, we give an explicit recur- sive formula for computing supersymmetric Wilson loop averages in 3d N = 2 Yang-Mills-Chern-Simons U(N) theory on the squashed sphere Sb3 with one adjoint chiral and two antichiral fundamental multiplets, for specific values of Chern-Simons level kappa(2) and Fayet- Illiopoulos parameter kappa(1). For these values of kappa(1) and kappa(2) the north and south pole turn out to be completely independent, and therefore Wilson loop averages factorize into answers for the two constituent D(2)x S-1 theories. In particular, our formula provides results for the theory on the round sphere when the squashing is removed.

  • Barney, Andrew
    et al.
    Gotland University. National Network for Wind Power Utilization.
    Aldén, Liselotte
    Gotland University.
    Engberg Ekman, Marita
    Gotland University.
    New and Ongoing Wind Power Research in Sweden 2011-20122013Report (Other (popular science, discussion, etc.))
  • Barney, Andrew
    et al.
    Gotland University. Noden för utbildnings- och kompetensfrågor i Nätverket för vindbruk.
    Aldén, Liselotte
    Gotland University.
    Engberg Ekman, Marita
    Gotland University.
    Ny och pågående vindkraftsforskning i Sverige 2011-20122013Report (Other (popular science, discussion, etc.))
  • Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Noden för utbildning- och kompetensfrågor i Nätverket för vindbruk.
    Barney, Andrew
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Engberg Ekman, Marita
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Vindkraftteknikerutbildningar i Sverige åren 2014-2018 - en analys2016Report (Other (popular science, discussion, etc.))
  • Bettoni, S.
    et al.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Divall, M. Csatari
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Ganter, R.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Pedrozzi, M.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Prat, E.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Reiche, S.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Schietinger, T.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Trisorio, A.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Vicario, C.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland.
    Goryashko, Vitaliy
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    Impact of laser stacking and photocathode materials on microbunching stability in photoinjectors2020In: PHYSICAL REVIEW ACCELERATORS AND BEAMS, ISSN 2469-9888, Vol. 23, no 2, article id 024401Article in journal (Refereed)
    Abstract [en]

    Microbunching instability is a well-known phenomenon that may deteriorate the performance of accelerators. The instability may be triggered by a shot-noise mechanism or by some initial intensity modulations at the generation of the electron bunch (or both) and can be amplified all along the machine. At SwissFEL, the free-electron laser (FEL) facility operating at the Paul Scherrer Institute (PSI), the initial design stipulated a shaping of the photocathode laser output to obtain a flat-top longitudinal profile. This scheme is attractive in terms of the uniformity of the beam properties along the bunch. The drawback of this approach is that some unavoidable modulations are generated along the laser pulse. We investigate, both experimentally and by numerical simulations, the longitudinal dynamics of a beam obtained illuminating a copper cathode with a laser profile shaped by the stacking technique. We repeat the analysis for several compression factors and initial laser profile modulations. We find that the microbunching instability gain renders the use of the stacking technique not efficient to run a free-electron laser facility using as photocathode a material with a short response time. We experimentally demonstrate that the use of a material with a longer response time efficiently damps the structures originating from the laser profile obtained with stacking, and helps to improve the performance of the facility. In general, this is an approach to minimize the microbunching instability at any FEL (also not using stacking) or at least reduce the use of other countermeasures, which, such as the laser heater, may degrade the final FEL performance.

  • Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Noden för utbildning och kompetensfrågor i Nätverket för vindbruk.
    Engberg Ekman, Marita
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Liljenfeldt, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Mardi, Josefin
    Att kommunicera vindkraftsforskning: Rapport om kommunikationsinsatser vid forskningsprogram inom vindkraftsområdet2017Report (Other (popular science, discussion, etc.))
  • Bergengren, Oskar
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Garmo, Hans
    Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.
    Bratt, Ola
    Sahlgrens Acad, Dept Urol, Gothenburg, Sweden.
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    Johansson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Bill-Axelson, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Determinants for choosing and adhering to active surveillance for localised prostate cancer: a nationwide population-based study2019In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 9, no 12, article id e033944Article in journal (Refereed)
    Abstract [en]

    Objective: Knowledge about factors influencing choice of and adherence to active surveillance (AS) for prostate cancer (PC) is scarce. We aim to identify which factors most affected choosing and adhering to AS and to quantify their relative importance.

    Design, setting and participants; In 2015, we sent a questionnaire to all Swedish men aged <= 70 years registered in the National Prostate Cancer Register of Sweden who were diagnosed in 2008 with low-risk PC and had undergone prostatectomy, radiotherapy or started on AS.

    Outcome measurements and statistical analysis: Logistic regression was used to calculate ORs with 95% CIs for factors potentially affecting choice and adherence to AS.

    Results: 1288 out of 1720 men (75%) responded, 451 (35%) chose AS and 837 (65%) underwent curative treatment. Of those starting on AS, 238 (53%) diverted to treatment within 7 years. Most men (83%) choose AS because 'My doctor recommended AS'. Factors associated with choosing AS over treatment were older age (OR 1.81, 95% CI 1.29 to 2.54), a Charlson Comorbidity Index >2 (OR 1.50, 95% CI 1.06 to 2.13), being unaccompanied when notified of the cancer diagnosis (OR 1.45, 95% CI 1.11 to 1.89). Men with a higher prostate-specific antigen (PSA) at the time of diagnosis were less likely to adhere to AS (OR 0.26, 95% CI 0.10 to 0.63). The reason for having treatment after initial AS was 'the PSA level was rising' in 55% and biopsy findings in 36%.

    Conclusions: A doctors recommendation strongly affects which treatment is chosen for men with low-risk PC. Rising PSA values were the main factor for initiating treatment for men on AS. These findings need be considered by healthcare providers who wish to increase the uptake of and adherence to AS.

  • Carlson, Erik
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Ethics and Social Philosophy.
    Johansson, Jens
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Ethics and Social Philosophy.
    Bontly on Harm and the Non-Identity Problem2019In: Utilitas, ISSN 0953-8208, E-ISSN 1741-6183, Vol. 31, no 4, p. 477-481Article in journal (Other academic)
    Abstract [en]

    The 'non-identity problem' raises a well-known challenge to the person-affecting view, according to which an action can be wrong only if it affects someone for the worse. In a recent article, however, Thomas D. Bontly proposes a novel way to solve the non-identity problem in person-affecting terms. Bontly's argument is based on a contrastive causal account of harm. In this response, we argue that Bontly's argument fails even assuming that the contrastive causal account is correct.

  • Broqvist, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Dissolved organic matter (DOM) quality in agricultural streams and its impact on carbon dioxide concentrations in stream water2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Inland waters have lately been recognized to be an important component in the carbon cycle, having a significant role in carbon sequestration and carbon dioxide (CO2) emissions. Attention has also been drawn to the impact of the quality (i.e. composition and source) of dissolved organic matter (DOM) on CO2 production.

    The objective of this study was to identify geographical and hydrochemical controls on DOM quality and quantity in agricultural streams, and to investigate if DOM quality has an impact on CO2 concentrations in stream water. Water samples were collected in July-November from ten streams in agricultural catchments in Uppsala, in which partial pressure of CO2 (pCO2) had been measured in a related M.Sc. thesis project. Fluorescence measurements and Parallel Factor Analysis (PARAFAC) were carried out to analyse DOM quality. Fluorescence Index (FI), Freshness Index (β/α), Humification Index (HIX) and a five-component PARAFAC model were derived and used to parametrize DOM quality. Dissolved organic carbon (DOC) concentration was used as a measure of DOM quantity.

    The fraction of arable land in the catchment was found to be positively correlated with FI, indicating a shift towards more microbially derived DOM with more arable land in the catchment. Two PARAFAC components associated with terrestrial and highly decomposed DOM were found to correlate positively with pCO2 at one site. Specific discharge and electrical conductivity were correlated with DOM quality and quantity at several sites. The correlations indicated that both the discharge magnitude as well as the flow paths affected the quality and the quantity of DOM.

  • Ekenhill, Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Att göra läsningen angelägen: Didaktiska möjligheter och hinder i arbetet med att väcka elevers intresse för läsning2020Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of the study has been to contribute with knowledge of opportunities and obstacles in teachers' work creating reading interest in students with varied linguistic backgrounds and abilities. Previous research, international and national reviews and reports show a trend of a declining interest in reading among our students and research on how the trend can be reversed. The study was conducted through a qualitative approach where seven teachers with different teaching experience from preschool class to high school were selected on the basis that they were deemed to have succeeded particularly well in their work in promoting reading interest in their student groups. One of the teachers interviewed has been studied more closely through observation and interview with five students in the teacher's teaching group.The informants have been interviewed. Interviews have been transcribed and analyzed through meaning concentration and after that thematic content analysis. The analysis has culminated in seven didactic themes that may be thought to arouse reading interest and six themes that are perceived as obstacles in reading promotion. Didactic aspects that appear to be important in the work of creating reading interest have been compiled under the following seven themes: Making the reading relevant, Emotional touch, Together, the art of asking questions, Empathic curiosity towards the student’s choice, Time and accessibility and finally Didactic development in the meeting with the difficult. Obstacles that have emerged in the study have been described under the following themes: Goals and assessment, Inadequate teaching and negative reading experiences, Reading behavioral norms, Inadequate collaboration, Competition with other things and School segregation. In the pupils interviews a separate theme can be discerned for the group named Concentration and Fatigue. The results have been discussed in relation to previous research and most of the study's themes can be related to - and confirmed by the results of previous research.The results have been discussed in relation to  didactic theory through Liberg's (2017) five dimensions of Didactic Relief. The dimensions that are most evident in relation to the study's empirical data are the student experience dimension, the generalizing dimension, and the creative, forward-looking dimension, the disciplinary and perspectival dimensions characterize the relief on the basis of a critical perspective on teaching content and regulations and can be linked to the study's themes on obstacles in the work of attracting reading interest.

  • Hedeland, Ylva
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. Uppsala University Hospital, Uppsala, Sweden.
    Gustafsson, Christina M
    Uppsala University Hospital, Uppsala, Sweden.
    Touza, Zinah
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Ridefelt, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. Uppsala University Hospital, Uppsala, Sweden.
    Hemolysis interference in 10 coagulation assays on an instrument with viscosity-based, chromogenic, and turbidimetric clot detection2020In: International Journal of Laboratory Hematology, ISSN 1751-5521, E-ISSN 1751-553XArticle in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Hemolysate in plasma samples from patients may cause misleading results in coagulation assays. Even though modern coagulation instruments often are equipped with modules that can detect hemolysis, icterus, and lipemia (HIL), studies that report the influence of these interferences are still limited. The present paper focuses on the influence of hemolysis on 10 coagulation assays.

    METHODS: Artificial hemolysis was created by freezing/thawing, and the hemolysates generated were added to pools of patient plasma. Pathological and normal levels were pooled separately. These spiked samples were analyzed on a STA R Max 2 instrument. The coagulation assays evaluated utilize clot, chromogenic, or immunoturbidimetric detection.

    RESULTS: Four of the evaluated assays were not influenced by hemolysis: fibrinogen, von Willebrand factor antigen, activated partial thromboplastin time, and factor VIII. Interestingly, normal and slightly elevated prothrombin time (INR < 2.0) was insensitive to hemolysis, whereas samples with a high INR (≥2.0) exhibited falsely high readings. The assays for antithrombin and fibrin D-dimer displayed an intermediate sensitivity to hemolysis. The most sensitive assay turned out to be anti-Xa, followed by protein C and protein S. For the anti-Xa assay, the results are decreased by 10% already at 0.5 g/L hemoglobin.

    CONCLUSION: The present study shows that hemolysis affects several of commonly used coagulation assays. Since the sensitivity for hemolysis is dependent on the brand of the assay as well as the instrument and principle of measurement, it is necessary to evaluate the influence of each specific combination.

  • Krebs, Alice
    et al.
    Univ Konstanz, Dept inaugurated Doerenkamp Zbinden Fdn, Vitro Toxicol & Biomedicine, Univ Str 10, D-78464 Constance, Germany;Univ Konstanz, Konstanz Res Sch Chem Biol KoRS CB, Constance, Germany.
    Waldmann, Tanja
    Univ Konstanz, Dept inaugurated Doerenkamp Zbinden Fdn, Vitro Toxicol & Biomedicine, Univ Str 10, D-78464 Constance, Germany.
    Wilks, Martin F.
    Univ Basel, Swiss Ctr Appl Human Toxicol, Basel, Switzerland.
    van Vugt-Lussenburg, Barbara M. A.
    BioDetect Syst BV, Amsterdam, Netherlands.
    van der Burg, Bart
    BioDetect Syst BV, Amsterdam, Netherlands.
    Terron, Andrea
    European Food Safety Author, Parma, Italy.
    Steger-Hartmann, Thomas
    Bayer AG, Invest Toxicol Drug Discovery Pharmaceut, Wuppertal, Germany.
    Ruegg, Joelle
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Rovida, Costanza
    Univ Konstanz, CAAT Europe, Constance, Germany.
    Pedersen, Emma
    RISE Res Inst Sweden, Gothenburg, Sweden.
    Pallocca, Giorgia
    Univ Konstanz, CAAT Europe, Constance, Germany.
    Luijten, Mirjam
    Natl Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands.
    Leite, Sofia B.
    European Commiss, Joint Res Ctr JRC, Ispra, Italy.
    Kustermann, Stefan
    Pharmaceut Sci Roche Innovat Ctr, F Hoffmann Roche, Pharma Res & Early Dev, Basel, Switzerland;Philip Morris Int R&D, Neuchatel, Switzerland.
    Kamp, Hennicke
    Philip Morris Int R&D, Neuchatel, Switzerland.
    Hoeng, Julia
    Philip Morris Int R&D, Neuchatel, Switzerland.
    Hewitt, Philip
    Merck KGaA, Non Clin Safety, Darmstadt, Germany.
    Herzler, Matthias
    German Fed Inst Risk Assessment, Dept Chem Safety, Berlin, Germany.
    Hengstler, Jan G.
    Tech Univ Dortmund, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany.
    Heinonen, Tuula
    Tampere Univ, Fac Med & Life Sci, FICAM, Tampere, Finland.
    Hartung, Thomas
    Johns Hopkins Univ, Ctr Alternat Anim Testing CAAT, Baltimore, MD USA.
    Hardy, Barry
    Edelweiss Connect GmbH, Technol Pk Basel, Basel, Switzerland.
    Gantner, Florian
    Boehringer Ingelheim Pharma GmbH Co KG, Translat Med Clin Pharmacol, Biberach, Germany.
    Fritsche, Ellen
    IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.
    Fant, Kristina
    Ezendam, Janine
    Exner, Thomas
    Dunkern, Torsten
    Grunenthal GmbH, Aachen, Germany.
    Dietrich, Daniel R.
    Univ Konstanz, Human & Environm Toxicol, Constance, Germany.
    Coecke, Sandra
    Busquet, Francois
    Univ Konstanz, CAAT Europe, Constance, Germany;ALTERTOX SPRL, Ixelles, Brussels, Belgium.
    Braeuning, Albert
    German Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany.
    Bondarenko, Olesja
    NICPB, Lab Environm Toxicol, Tallinn, Estonia.
    Bennekou, Susanne H.
    Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
    Beilmann, Mario
    Boehringer Ingelheim Pharma GmbH Co KG, Nonclin Drug Safety, Biberach, Germany.
    Leist, Marcel
    Univ Konstanz, Dept inaugurated Doerenkamp Zbinden Fdn, Vitro Toxicol & Biomedicine, Univ Str 10, D-78464 Constance, Germany;Univ Konstanz, Konstanz Res Sch Chem Biol KoRS CB, Constance, Germany;Univ Konstanz, CAAT Europe, Constance, Germany.
    Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data2019In: Altex, ISSN 1868-596X, E-ISSN 1868-8551, Vol. 36, no 4, p. 682-699Article in journal (Other academic)
    Abstract [en]

    Only few cell-based test methods are described by Organisation for Economic Co-operation and Development (OECD) test guidelines or other regulatory references (e.g., the European Pharmacopoeia). The majority of toxicity tests still falls into the category of non-guideline methods. Data from these tests may nevertheless be used to support regulatory decisions or to guide strategies to assess compounds (e.g., drugs, agrochemicals) during research and development if they fulfill basic requirements concerning their relevance, reproducibility and predictivity. Only a method description of sufficient clarity and detail allows interpretation and use of the data. To guide regulators faced with increasing amounts of data from non-guideline studies, the OECD formulated Guidance Document 211 (GD211) on method documentation for the purpose of safety assessment. As GD211 is targeted mainly at regulators, it leaves scientists less familiar with regulation uncertain as to what level of detail is required and how individual questions should be answered. Moreover, little attention was given to the description of the test system (i.e., cell culture) and the steps leading to it being established in the guidance. To address these issues, an annotated toxicity test method template (ToxTemp) was developed (i) to fulfill all requirements of GD211, (ii) to guide the user concerning the types of answers and detail of information required, (iii) to include acceptance criteria for test elements, and (iv) to define the cells sufficiently and transparently. The fully annotated ToxTemp is provided here, together with reference to a database containing exemplary descriptions of more than 20 cell-based tests.

  • Passén, Anders Wilhelm
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Dissertatio de caussis controversiarum theologicarum, quam ... publicæ censuræ subjiciunt mag. And. Wilh. Passén ... et Laurentius Hillberg, stipend. reg. helsingus. In audit. Gustaviano d. XXIV aprilis MDCCCII.1802Dissertation (older thesis) (Other academic)
  • Loncarski, Jelena
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity. Politecn Bari, Dept Elect & Informat Engn, Via E Orabona 4, I-70125 Bari, Italy.
    Monopoli, Vito Giuseppe
    Politecn Bari, Dept Elect & Informat Engn, Via E Orabona 4, I-70125 Bari, Italy.
    Leuzzi, Riccardo
    Politecn Bari, Dept Elect & Informat Engn, Via E Orabona 4, I-70125 Bari, Italy.
    Risti, Leposava
    Univ Belgrade, Dept Elect Engn, Belgrade 11120, Serbia.
    Cupertino, Francesco
    Politecn Bari, Dept Elect & Informat Engn, Via E Orabona 4, I-70125 Bari, Italy.
    Analytical and Simulation Fair Comparison of Three Level Si IGBT Based NPC Topologies and Two Level SiC MOSFET Based Topology for High Speed Drives2019In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 12, no 23, article id 4571Article in journal (Refereed)
    Abstract [en]

    Wide bandgap (WBG) power devices such as silicon carbide (SiC) can viably supply high speed electrical drives, due to their capability to increase efficiency and reduce the size of the power converters. On the other hand, high frequency operation of the SiC devices emphasizes the effect of parasitics, which generates reflected wave transient overvoltage on motor terminals, reducing the life time and the reliability of electric drives. In this paper, a SiC metal-oxide-semiconductor field-effect transistor (MOSFET) based two level (2L) inverter is systematically studied and compared to the performance of Si insulated-gate bipolar transistor (IGBT) based three level (3L) neutral point clamped (NPC) inverter topologies, for high speed AC motor loads, in terms of efficiency, overvoltages, heat sink design, and cost. A fair comparison was introduced for the first time, having the same output voltage capabilities, output current total harmonic distortion (THD), and overvoltages for the three systems. The analysis indicated the convenience of using the SiC MOSFET based 2L inverter for lower output power. In the case of the maximum output power, the heat sink volume was found to be 20% higher for the 2L SiC based inverter when compared to 3L NPC topologies. Simulations were carried out by realistic dynamic models of power switch modules obtained from the manufacturer's experimental tests and verified both in the LTspice and PLECS simulation packages.

  • Grandi, Nicole
    et al.
    Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato SS554, Cagliari, Italy.
    Pisano, Maria Paola
    Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato SS554, Cagliari, Italy.
    Demurtas, Martina
    Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato SS554, Cagliari, Italy.
    Blomberg, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology.
    Magiorkinis, Gkikas
    Univ Saarland, Inst Human Genet, Homburg, Germany.
    Mayer, Jens
    Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece.
    Tramontano, Enzo
    Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato SS554, Cagliari, Italy;CNR, IRGB, Cagliari, Italy.
    Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primates2020In: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 11, article id 6Article in journal (Refereed)
    Abstract [en]

    Background: Endogenous Retroviruses (ERVs) constitute approximately 8% of every human genome and are relics of ancestral infections that affected the germ line cells. The ERV-W group contributed to primate physiology by providing an envelope protein (Syncytin-1) that has been adopted for placenta development in hominoids. Expression of Human ERV-W (HERV-W) sequences is investigated for a pathological role in various human diseases.

    Results: We previously characterized ERV-W group genomic sequences in human and non-human Catarrhini species. We now investigated ERV-W-like sequences in the parvorder Platyrrhini, especially regarding two species with complete genome assemblies, namely marmoset (Callithrix jacchus) and squirrel monkey (Saimiri boliviensis). We identified in both species proviral sequences, annotated as ERV1-1 in respective genome assemblies, sharing high sequence similarities with Catarrhini ERV-W. A total of 130 relatively intact proviruses from the genomes of marmoset and squirrel monkey were characterized regarding their structural and evolutionarily relationships with Catarrhini ERV-W elements. Platyrrhini ERV-W sequences share several structural features with Catarrhini ERV-W elements and are closely related phylogenetically with the latter as well as with other ERV-W-related gammaretrovirus-like ERVs. The ERV-W group colonized Platyrrhini primates of both Callitrichidae and Atelidae lineages, with provirus formations having occurred mostly between 25 and 15 mya. Two LTR subgroups were associated with monophyletic proviral bodies. A pre-gag region appears to be a sequence feature common to the ERV-W group: it harbors a putative intron sequence that is missing in some ERV-W loci, holding a putative ORF as well. The presence of a long pre-gag portion was confirmed among all gammaretroviral ERV analyzed, suggesting a role in the latter biology. It is noteworthy that, contrary to Catarrhini ERV-W, there was no evidence of L1-mediated mobilization for Platyrrhini ERV-W sequences.

    Conclusions: Our data establish that ERV-W is not exclusive to Catarrhini primates but colonized both parvorders of Simiiformes, providing further insight into the evolution of ERV-W and the colonization of primate genomes.

  • Cayao, Jorge
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Triola, Christopher
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Black-Schaffer, Annica M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Odd-frequency superconducting pairing in one-dimensional systems2020In: The European Physical Journal Special Topics, ISSN 1951-6355, E-ISSN 1951-6401, Vol. 229, no 4, p. 545-575Article, review/survey (Refereed)
    Abstract [en]

    Odd-frequency superconductivity represents a truly unconventional ordered state which, in contrast to conventional superconductivity, exhibits pair correlations which are odd in relative time and, hence, inherently dynamical. In this review article we provide an overview of recent advances in the study of odd-frequency superconducting correlations in one-dimensional systems. In particular, we focus on recent developments in the study of nanowires with Rashba spin-orbit coupling and metallic edges of two-dimensional topological insulators in proximity to conventional superconductors. These systems have recently elicited a great deal of interest due to their potential for realizing one-dimensional topological superconductivity whose edges can host Majorana zero modes. We also provide a detailed discussion of the intimate relationship between Majorana zero modes and odd-frequency pairing. Throughout this review, we highlight the ways in which odd-frequency pairing provides a deeper understanding of the unconventional superconducting correlations present in each of these intriguing systems and how the study and control of these states holds the potential for future applications.

  • Gentili, Charlotte
    et al.
    Karolinska Univ Hosp, Funct Unit Behav Med, Funct Area Med Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Westin, Vendela Zetterqvist
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Karolinska Univ Hosp, Funct Unit Behav Med, Funct Area Med Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Rickardsson, Jenny
    Karolinska Univ Hosp, Funct Unit Behav Med, Funct Area Med Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Holmström, Linda
    Karolinska Univ Hosp, Funct Unit Behav Med, Funct Area Med Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
    Simons, Laura E.
    Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94304 USA.
    Wicksell, Rikard K.
    Karolinska Univ Hosp, Funct Unit Behav Med, Funct Area Med Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    ACTsmart - development and feasibility of digital Acceptance and Commitment Therapy for adults with chronic pain2020In: NPJ DIGITAL MEDICINE, ISSN 2398-6352, Vol. 3, article id 20Article in journal (Refereed)
    Abstract [en]

    Accessibility of evidence-based behavioral health interventions is one of the main challenges in health care and effective treatment approaches are not always available for patients that would benefit from them. Digitization has dramatically changed the health care landscape. Although mHealth has shown promise in addressing issues of accessibility and reach, there is vast room for improvements. The integration of technical innovations and theory driven development is a key concern. Digital solutions developed by industry alone often lack a clear theoretical framework and the solutions are not properly evaluated to meet the standards of scientifically proven efficacy. On the other hand, mHealth interventions developed in academia may be theory driven but lack user friendliness and are commonly technically outdated by the time they are implemented in regular care, if they ever are. In an ongoing project aimed at scientific innovation, the mHealth Agile Development and Evaluation Lifecycle was used to combine strengths from both industry and academia in the development of ACTsmart - a smartphone-based Acceptance and Commitment Therapy treatment for adult chronic pain patients. The present study describes the early development of ACTsmart, in the process of moving the product from alpha testing to a clinical trial ready solution.

  • Graf, Wilhelm
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    Birgisson, Helgi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    ASO Author Reflections: Can Patient Selection for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy be Improved?2020In: Annals of Surgical Oncology, ISSN 1068-9265, E-ISSN 1534-4681, Vol. 27, no 1, p. 301-302Article in journal (Other academic)
  • Wärnberg, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    Karakatsanis, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    ASO Author Reflections: SPIO, a New Sentinel Node Tracer with Interesting Future Clinical Applications2019In: Annals of Surgical Oncology, ISSN 1068-9265, E-ISSN 1534-4681, Vol. 26, p. S639-S640Article in journal (Other academic)
  • Panda, Pritam Kumar
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Grigoriev, Anton
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Mishra, Yogendra Kumar
    Univ Southern Denmark, NanoSYD, Mads Clausen Inst, Alsion 2, DK-6400 Odense, Denmark.
    Ahuja, Rajeev
    Royal Inst Technol KTH, Dept Mat & Engn, SE-10044 Stockholm, Sweden.
    Progress in supercapacitors: roles of two dimensional nanotubular materials2020In: NANOSCALE ADVANCES, ISSN 2516-0230, Vol. 2, no 1, p. 70-108Article, review/survey (Refereed)
    Abstract [en]

    Overcoming the global energy crisis due to vast economic expansion with the advent of human reliance on energy-consuming labor-saving devices necessitates the demand for next-generation technologies in the form of cleaner energy storage devices. The technology accelerates with the pace of developing energy storage devices to meet the requirements wherever an unanticipated burst of power is indeed needed in a very short time. Supercapacitors are predicted to be future power vehicles because they promise faster charging times and do not rely on rare elements such as lithium. At the same time, they are key nanoscale device elements for high-frequency noise filtering with the capability of storing and releasing energy by electrostatic interactions between the ions in the electrolyte and the charge accumulated at the active electrode during the charge/discharge process. There have been several developments to increase the functionality of electrodes or finding a new electrolyte for higher energy density, but this field is still open to witness the developments in reliable materials-based energy technologies. Nanoscale materials have emerged as promising candidates for the electrode choice, especially in 2D sheet and folded tubular network forms. Due to their unique hierarchical architecture, excellent electrical and mechanical properties, and high specific surface area, nanotubular networks have been widely investigated as efficient electrode materials in supercapacitors, while maintaining their inherent characteristics of high power and long cycling life. In this review, we briefly present the evolution, classification, functionality, and application of supercapacitors from the viewpoint of nanostructured materials to apprehend the mechanism and construction of advanced supercapacitors for next-generation storage devices.

  • Rojas-Lopez, Laura
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology. Publ Hlth Agcy Sweden, S-17182 Solna, Sweden.
    Elwin, Kristin
    Singleton Hosp Sgeti, Cryptosporidium Reference Unit, Publ Hlth Wales Microbiol & Hlth Protect, Swansea SA2 8QA, W Glam, Wales;Swansea Univ, Med Sch, Grove Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
    Chalmers, Rachel M.
    Singleton Hosp Sgeti, Cryptosporidium Reference Unit, Publ Hlth Wales Microbiol & Hlth Protect, Swansea SA2 8QA, W Glam, Wales;Swansea Univ, Med Sch, Grove Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
    Enemark, Heidi L.
    Natl Vet Inst, Ullevalsveien 68, N-0454 Oslo, Norway.
    Beser, Jessica
    Publ Hlth Agcy Sweden, S-17182 Solna, Sweden.
    Troell, Karin
    Natl Vet Inst, S-75189 Uppsala, Sweden.
    Development of a gp60-subtyping method for Cryptosporidium felis2020In: Parasites & Vectors, ISSN 1756-3305, E-ISSN 1756-3305, Vol. 13, article id 39Article in journal (Refereed)
    Abstract [en]

    Background: Feline cryptosporidiosis is an increasing problem, especially in catteries. In humans, close contact with cats could be a potential source of infection although the risk of contracting cryptosporidiosis caused by Cryptosporidium felis is considered to be relatively low. Sequencing of the 60-kDa glycoprotein gene is a commonly used tool for investigation of the genetic diversity and transmission dynamics of Cryptosporidium species. However, until now the sequence of gp60 from C. felis has not been available and genotyping has been limited to less discriminatory markers, such as 18S rRNA, COWP and HSP70.

    Methods: We have identified the gp60 orthologue within the genome sequence of C. felis, and used the sequence to design a nested PCR for subtyping purposes. A total of 128 clinical isolates of both feline and human origin, were used to evaluate the marker.

    Results: Sequence analysis revealed large variations between the different samples. The C. felis gp60 lack the characteristic serine-tract found in many other cryptosporidian orthologues, instead it has an insertion of variable length (361-742 nt). Also, two cases of suspected zoonotic transmission of C. felis between cats and humans were successfully confirmed.

    Conclusions: We have identified the gp60 gene in C. felis and show how this highly variable marker can be used in epidemiological investigations.

  • David, Markström
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Vikström, Dan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Likaviktad eller Värdeviktad: - Slår en likaviktad portfölj det värdeviktade indexet OMXS30GI?2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study contains the results of an equally-weighted portfolio, rebalanced semi-annually, and its performance compared to the value-weighted index OMXS30GI. Both the portfolio and the index contain the 30 most traded stocks at Nasdaq Stockholm during the period 2003–2016. The results show that the equally-weighted portfolio performs at a better risk-adjusted rate than the value-weighted index during the entire period and both two sub-periods. However, the higher risk-adjusted return is not statistically significant, which instead suggest that the higher rate of return is due to an exposure to the market risk factor and the HML-factor.

  • Björklund, Kajsa
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Falk, Kerstin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Den goda viljans förmåga att skapa goda förvärv: Påverkar reaktionen på aktiemarknaden efter ett uppköp avskrivningen av goodwill?2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna uppsats ämnar undersöka om det finns ett samband mellan reaktionen på stockholmsbörsen direkt efter ett uppköp tillkännages och hur svenska börsnoterade företag har valt att genomföra goodwillavskrivningar de efterföljande två åren. Studien har begränsats till företag med huvudkontor i Sverige inom tidsperioden 2011–2016, detta gav ett slutgiltigt urval på 74 företag. Sambandet som granskas är det mellan den beroende variabeln goodwillavskrivningar och den oberoende variabeln aktiemarknadens reaktion på tillkännagivandet, förutom dessa har även möjliga samband med kontrollvariablerna storlek på tillgångar och EBITDA undersökts. Detta har analyserats med hjälp av en eventstudie med ett eventfönster på tre dagar, en korrelationsmatris samt en linjär regressionsanalys.

    Resultaten antyder att aktiemarknadens reaktion kan påverka de efterföljande goodwillavskrivningarna under både det första och det andra året. Likaså fann vi ett samband mellan goodwillavskrivningar det första och andra året.

  • Isaac, Andreas
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Haglund, Joel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hur påverkar digitaliseringen internationaliseringsprocessen för ett International New Venture?2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Internationaliseringsprocessen är ett forskningsområde som har studerats under en lång tid. Men många modeller är äldre, tar inte tillräcklig hänsyn till digitaliseringen som fenomen och tar inte hänsyn till mindre bolag. Därför ställs frågan ​på vilket sätt påverkar digitaliseringen ett International New Ventures internationaliseringsprocess? För att kunna besvara på detta har en kvalitativ studie gjorts där totalt tre personer har intervjuats från tre olika företag. Utifrån dessa intervjuer har analyser gjorts som sedan har återkopplat till den teoretiska bakgrunden. Slutsatsen som dras är att digitaliseringen har förenklat internationaliseringsprocessen främst genom framsteg i hur kunskap kan insamlas och delas över stora avstånd.

  • Karem, Allan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sjögren, Mårten
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Företagsförvärv av teknik och industribolag: hur branschtillhörighet påverkar abnorm avkastning2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Förvärvsaktiviteten i världen har ökat drastiskt de senaste decennierna. Likaså har en stor mängd forskning publicerats om vad förvärvarens konsekvenser blir för de berörda bolagen. Idag utgörs en allt större andel av dessa förvärv av teknikbolag. De är särskilt intressanta då de särskiljer sig från bolag i andra branscher med dess potentiella snabba värdeökning samt de möjliga synergieffekter som kan uppstå. Samtidigt anses de vara osäkra i och med att avkastningen baseras på resultaten av dess forskning och utveckling. Genom en eventstudie med 69 stycken genomförda förvärv, 33 från industribranschen och 36 från teknologibranschen undersöks om det finns någon skillnad på den kortsiktiga reaktionen för det uppköpta bolaget på den nordiska marknaden mellan 2000-01-01 och 2019-01-01. Resultatet av eventstudien visade att det finns en skillnad på hur företagens abnorma avkastning påverkas av branschtillhörighet vid företagsförvärv.

  • Vogel, Jonathan
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Stänkelström, Aedan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Varumärkesrelationer och smartphones: En kvantitativ studie på unga konsumenter2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Franquiz, Ludwing
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Jonsson, Jonathan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hur återetableras företagsrelationer?2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna kvalitativa studie, som har genomförts hos ett stort svenskt IT-företag, beskriver vilka skillnader och likheter det finns på hur företag återetablerar relationer till företag inom offentlig och privat sektor. Syftet med denna uppsats är att undersöka skillnader och likheter mellan hur processen ser ut för företag att återetablera relationer till privata företag och offentliga myndigheter. För att besvara hur företag återetablerar sina företagsrelationer undersöktes anledning till avslut i tidigare relation och hur avslutet hanterades av företag och kund.

    Data samlades in genom att intervjua sex stycken kundansvariga säljare som hade ansvar för kunder inom både offentlig och privat sektor. Studien har visat på att det både finns skillnader och likheter mellan offentlig och privat sektor om anledning till avslut, hur avslut hanteras och hur relationer återetableras. Resultaten från studien visar att tidigare forskning om hur företag återetablerar relationer överensstämmer mer inom privat än offentlig sektor.

  • Kälin, Gregor
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Porto, Rafael A.
    Deutsch Elektronen Synchrotron DESY, Notkestr 85, D-22607 Hamburg, Germany;Abdus Salam Int Ctr Theoret Phys, Str Costiera 11, I-34151 Trieste, Italy.
    From boundary data to bound states2020In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, article id 72Article in journal (Refereed)
    Abstract [en]

    We introduce a - somewhat holographic - dictionary between gravitational observables for scattering processes (measured at the boundary) and adiabatic invariants for bound orbits (in the bulk), to all orders in the Post-Minkowskian (PM) expansion. Our map relies on remarkable connections between the relative momentum of the two-body problem, the classical limit of the scattering amplitude and the deflection angle in hyperbolic motion. These relationships allow us to compute observables for generic orbits (such as the periastron advance increment phi) through analytic continuation, via a radial action depending only on boundary data. A simplified (more geometrical) map can be obtained for circular orbits, enabling us to extract the orbital frequency as a function of the (conserved) binding energy, omega(E), directly from scattering information. As an example, using the results in Bernet al. [36, 37], we readily derive omega(E) and increment phi(J, E) to two-loop orders. We also provide closed-form expressions for the orbital frequency and periastron advance at tree-level and one-loop order, respectively, which capture a series of exact terms in the Post-Newtonian expansion. We then perform a partial PM resummation, using a no-recoil approximation for the amplitude. This limit is behind the map between the scattering angle for a test-particle and the two-body dynamics to 2PM. We show that it also captures a subset of higher order terms beyond the test-particle limit. While a (rather lengthy) Hamiltonian may be derived as an intermediate step, our map applies directly between gauge invariant quantities. Our findings provide a starting point for an alternative approach to the binary problem. We conclude with future directions and some speculations on the classical double copy.

  • Danielsson, Johanna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ahlberg, Elin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Alltid nåbar - aldrig fri: En studie om hur unga vuxna upplever mobiltelefoner2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Utvecklingen av modern teknologi går fort framåt. Det är inte länge sedan mobiltelefoner var stora, klumpiga och endast kunde användas till att ringa samtal. Dagens smartmobiler erbjuder många fler funktioner än så. Utöver att vara ett verktyg för att upprätthålla sociala relationer gör mobiler det möjligt att enkelt och snabbt uträtta en mängd ärenden, något som uppskattas i vårt moderna samhälle. Mobiltelefonen utgör en central del av många människors liv. I Sverige äger i stort sett alla en mobiltelefon och personer som blickar ner i sin mobil syns överallt. Eftersom att utvecklingen skett så snabbt vet vi inte säkert hur all mobilanvändning påverkar oss och vårt samhälle i det långa loppet. Forskning som gjorts visar på potentiella faror och allvarliga konsekvenser med att spendera mycket tid med sin mobil. Förutom att mycket mobilanvändning kan orsaka sämre fysisk hälsa kan det även vara skadligt för människors mentala hälsa. Ökad ångest och stress över att ständigt vara uppkopplad är exempel på vad mobilanvändandet kan orsaka. Denna studies syfte är att undersöka hur unga vuxna upplever sin mobiltelefon och hur de upplever att mobiltelefoner påverkar sociala relationer. Genom att använda oss av en fenomenologisk analysmetod har vi sammanställt resultatet från tio intervjuer där vi bett unga vuxna berätta om sina upplevelser. I vår analys har vi använt Herbert Marcuses kritiska teori och Erving Goffmans dramaturgiska teori. Vårt resultat pekar på att unga vuxna upplever både för- och nackdelar med sina mobiltelefoner. Samtliga respondenter upplever sig vara beroende av sina mobiltelefoner, och spenderar mer tid med sina mobiler än vad de trodde. När det gäller mobiltelefonens roll i sociala situationer upplever många att mobiler kan störa umgänget. Trots detta är alla de vi har intervjuat överens om att en mobiltelefon idag är en social nödvändighet för att inte hamna utanför.

  • Lundahl, Viviane
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Helt vanlig tjej eller manipulativ och häxlik?: En kritisk diskurspsykologisk analys av hur kvinnliga mördare representeras i kvällspressen2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I denna uppsats undersöks hur gärningspersonerna i fallen Arbogakvinnan och Styckmordet i Askersund representerats i svensk kvällspress. Syftet med uppsatsen är att med en kritiskt diskurspsykologisk ansats studera hur de kvinnliga mördarna representerades i brottsrapporteringen av fallen under de första sex månaderna efter att brotten begåtts. För att besvara syftet har jag analyserat artiklar publicerade av Expressen och Aftonbladet i samband med fallen. Analysen har gjorts på totalt 40 nyhetsartiklar som är av olika längd. Studien motiveras delvis av bristfällig aktuell forskning av kvinnliga mördare i media i Sverige, delvis av vikten att undersöka hur meningsproducenter, såsom kvällstidningar, (re)producerar bilder av kvinnliga kriminella.  Jag har använt mig av diskurspsykologisk teori och Stuart Halls teori om representation för att identifiera tolkningsrepertoarer, subjektspositioner och könade föreställningar om kvinnliga förövare som ligger till grund för brottsrapporteringen. Analysen visar på två tolkningsrepertoarer som jag valt att benämna som Relaterbar normalitet och Icke-relaterbar avvikelse. Vidare urskildes fem subjektspositioner: den okvinnliga kvinnan, den helt vanliga kvinnan, den känslostyrda kvinnan, den beräknande kvinnan och den oberäkneliga kvinnan. I tillägg till detta fanns tendenser till att konstruera den kvinnliga mördaren som häxlik och en reducerande kategorisering av henne som antingen “mad”, det vill säga galen, eller “bad”, det vill säga ond och farlig.

  • Vejbrink Kildal, Adrian
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Maarof, Mohammad
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Den bortglömda förändringen: En kvalitativ studie om Arbetsförmedlingens förnyelseresa2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Vi lever i en tid då förändringar är en naturlig del av organisationers vardag. Det finns ett stort krav på att organisationer ska vara flexibla för att kunna möta de omvärldskrav som ständigt skiftar. Förändringsprocesser innebär ofta en mer eller mindre omfattande omstrukturering av verksamheten vilket kan påverka tryggheten i organisationen under en period. Det är inte ovanligt att förändringar avlöser varandra och att nya förändringsprocesser initieras innan de tidigare har hunnit avslutas. Men vad innebär detta för implementeringen av de tidigare förändringarna när energi och fokus riskerar att riktas mot nya förändringar? Det finns få studier som berör just detta område och med grund i dagens dynamiska och föränderliga klimat är det av vikt att undersöka hur implementeringen av nya förändringar påverkar förutsättningarna för de äldre förändringinsatserna. Därför har vi i denna studie undersökt hur en ny förändring påverkar bilden och implementeringen av den tidigare påbörjade förändringen och hur detta tar sig uttryck. Vi har gjort en kvalitativ studie i form av en textanalys och semistrukturerade intervjuer vid Arbetsförmedlingen. Myndigheten har genomgått en skakig period det senaste året, där en Reformering implementerats samtidigt som myndigheten befinner sig mitt i en långsiktig förändringsprocess, Förnyelseresan, som pågått i många år. Materialet bestod dels av en rapport från Statskontoret samt intervjuer med medarbetare och enhetschef från ett lokalt Arbetsförmedlingskontor. Det insamlade materialet har bearbetats och analyserats med hjälp av Hirschmans tre uttryck för missnöje samt Nyinstitutionell teori. I resultatet  identifierades en skillnad i representationen av Reformeringen påverkan på Förnyelseresan på nationell nivå, utifrån Statskontorets rapport, och den lokala nivån, utifrån intervjuerna. I rapporten förmedlades en bild av fungerande process som mottagits väl av organisationens medlemmar. På den lokala nivån framkom istället hur Reformeringen förflyttade fokus från Förnyelseresan och skapade en osäkerhet på arbetsplatsen. Medarbetare uppgav att de i princip hade glömt bort arbetet med Förnyelseresan och att man i dagsläget inte arbetade mot de mål som var uppställda i förändringen. Genom studien kunde vi även identifiera att medarbetarna upplevde ett missnöje i sin arbetssituation, vilket uttrycktes genom att lämna organisationen men även genom yttringar i media. Med den här studien hoppas vi kunna bidra med en bredare förståelse för hur parallella förändringar kan påverka varandras förutsättningar

  • Jansson, Ulrika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Döva i arbetslivet: En studie om upplevelser av utanförskap2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsen handlar om döva i arbetslivet. Meningen med uppsatsen är att undersöka om döva upplever sig utanför på sina arbetsplatser och i vilka situationer det uppstår. En av frågeställningarna är hur döva beskriver den språkliga interaktionen. Tidigare forskning visar att döva hamnar utanför på grund av de språkliga barriärerna. Det teoretiska ramverket som använts utgår från symbolisk interaktionism, känslohantering och interaktionistisk teori kring avvikelse. Insamlandet av data har skett genom kvalitativa intervjuer med åtta döva och gravt hörselskadade informanter på svenskt teckenspråk. Tolkande fenomenologisk analys, Interpretative phenomenological analysis, IPA, har använts och som fungerar särskilt bra när det handlar om upplevelser och känslor. Resultatet visar bland annat att några informanter upplever sig utanför på sina arbetsplatser och det beror på begränsade interaktioner eller helt enkelt att känna sig ensam som den enda döva på arbetsplatsen. Brister i kommunikationen som några av informanterna berättar om visar sig vara brister i interaktioner med sina kollegor.

  • Zojaji, Romina
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Salah, Robar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    "Jag lyckades inte i rollen som den duktiga flickan": En kvalitativ studie om tio före detta kriminella, dömda kvinnors livsberättelser och upplevelser av kriminalitet.2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie redogör för tio före detta kriminella, dömda kvinnors livsberättelser. Med utgångspunkt i kvalitativa, semistrukturerade intervjuer tar vi reda på hur kvinnorna påbörjade deras kriminalitet och hur de lyckades avsluta den kriminella perioden. Studien riktar sig även in på hur kvinnorna själva såg på sina identiteter samt vilka upplevelser av konsekvenser en kriminell livsstil haft på dessa kvinnor. Den fenomenologiska metodansatsen valdes för att få en djupare inblick i kvinnornas subjektiva upplevelser av kriminalitet. Resultatet från samtliga intervjuer har analyserats med hjälp av Hirschis social kontrollteori, Beckers teori om stämpling samt Goffmans teori om stigmatisering, roller och identitet. Resultatet visar att de potentiella faktorerna till att kvinnorna påbörjade en kriminell livsstil var på grund av deras uppväxtförhållanden, bekantskaper och psykisk ohälsa. Den största bakomliggande faktorn i den kriminella livsstilen var för nio av tio kvinnor ett missbruk. Skälen som angavs vid avslutandet av en kriminell livsstil var bland annat motivation, stöd och en högre grad av empati till sina närstående samt när kvinnorna nått sin personliga botten och fått nog av sin kriminella period och missbruk. Samtliga kvinnor har idag lyckats bryta de kriminella vanorna, lyckats skapa nya relationer och stärkt sina sociala band. När det gäller kvinnornas identitet visar resultatet att de under deras återberättande haft en negativ inställning till en kriminell livsstil samt att den påverkat deras självbild. Slutligen, vid talandet om upplevelser kring könsskillnader framställer kvinnorna den kriminella världen som mansdominerad. Utifrån kvinnornas egna åsikter tycks kriminalitet associeras med det manliga könet och att en kvinna i större utsträckning betraktas som en normbrytare om hon utför kriminella handlingar.

  • Källgren, Marcus
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Tohidi, Tina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Institutionalisering av CSR: Corporate Social Responsibility – en vedertagen praktik2020Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesis
    Abstract [sv]

    Corporate social responsibility (CSR) är en praktik som trots sin frivilliga innebörd blivit ett välförankrat element i organisationer och den verksamhet de bedriver. Mot bakgrund av detta syftar denna uppsats att utifrån ett nyinstitutionellt perspektiv undersöka de kontextuella sammanhang och villkor som ligger till grund för att CSR idag betraktas som ett vedertaget instrument inom företagsstyrning. Studien ämnar att kartlägga gemensamma uppfattningar om dessa villkor samt på vilket sätt företag väljer att adressera CSR utifrån dessa villkor. Med hjälp av semistrukturerade intervjuer har vi hört nio chefer inom CSR och hållbarhet belyser en tilltro till mellanstatliga direktiv; där FN:s Global Compactfungerar som ett ledsnöre för organisatorisk styrning som följaktligen utgör en interorganisatorisk standard för företag att förhålla sig till. Vidare konceptualiseras denna styrning genom verksamhetsnära strategier och processer, där omfattande delar av värdekedjan ses över och åtgärdas med olika CSR-inriktade initiativ. Denna verksamhetsnära förankring av CSR betraktas av respondenterna som ett konkurrensmedel för att vinna affärer, med uppfattningen om att det är en vital del i affärsverksamheten för att kunna legitimera sig gentemot andra kundföretag, i synnerhet större företag. Detta skapar en rationell mytbildning; en gemensam uppfattning om att företag måste involvera CSR i verksamheten för att ha en möjlighet att vara långsiktigt lönsamma. Det är i dessa interorganisatoriska relationer som vi, genom att betrakta CSR som en institution, belyser praktikens “tvingande” påverkan på stora företag, och därigenom ifrågasätter dess frivillighet ur ett organisationssociologiskt perspektiv.

  • Hedberg, Andreas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature, Sociology of Literature.
    Det diktade bruket: Skönlitterära berättelser om vallonbruk i Uppland 1787–20122013Book (Other academic)
  • Junker, Olov
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Helicity amplitudes for the transition from the spin-3/2 Sigma to the Lambda hyperon2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The helicity amplitudes of the scattering reaction Sigma* bar Lambda -> pi+ pi- at energies below 1 GeV are calculated. They are part of a project of determining the low energy Sigma* to Lambda transition form factors using dispersion theory. The helicity amplitudes require the Feynman amplitudes of Sigma* bar Lambda -> pi+ pi- as input. They are calculated to leading order in baryon chiral perturbation theory, where they contain intermediate Sigma and Sigma* hyperons. A projector formalism that facilitates the calculation of the Feynman amplitudes is developed. An anomalous cut contributes to the helicity amplitudes, making them discontinuous when Sigma is exchanged. The continuity of the helicity amplitudes is restored by an analytic continuation from the physical scattering region. The helicity amplitudes are found to converge fast to zero at energies above 1 GeV, as is desired in this low energy calculation. 

  • Petrenko, Volodymyr
    et al.
    Univ Geneva, Dept Med, Div Endocrinol Diabet & Nutr, CH-1211 Geneva, Switzerland;Univ Geneva, Fac Med, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland;Univ Geneva, Fac Med, Diabet Ctr, CH-1211 Geneva, Switzerland;Univ Geneva, Inst Genet & Genom Geneva, CH-1211 Geneva, Switzerland.
    Gandasi, Nikhil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Univ Goteborg, Inst Neurosci & Physiol, Dept Physiol, SE-40530 Gothenburg, Sweden.
    Sage, Daniel
    Ecole Polytech Fed Lausanne, Biomed Imaging Grp, CH-1015 Lausanne, Switzerland.
    Tengholm, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Barg, Sebastian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Dibner, Charna
    Univ Geneva, Dept Med, Div Endocrinol Diabet & Nutr, CH-1211 Geneva, Switzerland;Univ Geneva, Fac Med, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland;Univ Geneva, Fac Med, Diabet Ctr, CH-1211 Geneva, Switzerland;Univ Geneva, Inst Genet & Genom Geneva, CH-1211 Geneva, Switzerland.
    In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis2020In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 117, no 5, p. 2484-2495Article in journal (Refereed)
    Abstract [en]

    Circadian clocks operative in pancreatic islets participate in the regulation of insulin secretion in humans and, if compromised, in the development of type 2 diabetes (T2D) in rodents. Here we demonstrate that human islet alpha- and beta-cells that bear attenuated clocks exhibit strongly disrupted insulin and glucagon granule docking and exocytosis. To examine whether compromised clocks play a role in the pathogenesis of T2D in humans, we quantified parameters of molecular clocks operative in human T2D islets at population, single islet, and single islet cell levels. Strikingly, our experiments reveal that islets from T2D patients contain clocks with diminished circadian amplitudes and reduced in vitro synchronization capacity compared to their nondiabetic counterparts. Moreover, our data suggest that islet clocks orchestrate temporal profiles of insulin and glucagon secretion in a physiological context. This regulation was disrupted in T2D subjects, implying a role for the islet cell-autonomous clocks in T2D progression. Finally, Nobiletin, an agonist of the core-clock proteins ROR alpha/gamma, boosted both circadian amplitude of T2D islet clocks and insulin secretion by these islets. Our study emphasizes a link between the circadian clockwork and T2D and proposes that clock modulators hold promise as putative therapeutic agents for this frequent disorder.

  • Franco, Irene
    et al.
    Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden.
    Helgadottir, Hafdis T.
    Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden.
    Moggio, Aldo
    Karolinska Inst, Integrated Cardio Metab Ctr, Dept Med Huddinge, Huddinge, Sweden.
    Larsson, Malin
    Linkoping Univ, Dept Phys Chem & Biol, Sci Life Lab, Linkoping, Sweden.
    Vrtacnik, Peter
    Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden.
    Johansson, Anna C. V.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Norgren, Nina
    Umea Univ, Dept Mol Biol, Sci Life Lab, Umea, Sweden.
    Lundin, Par
    Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden;Stockholm Univ, DBB, Sci Life Lab, Stockholm, Sweden.
    Mas-Ponte, David
    Barcelona Inst Sci & Technol, Genome Data Sci, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain.
    Nordstrom, Johan
    Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Transplantat Surg, Huddinge, Sweden.
    Lundgren, Torbjorn
    Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Transplantat Surg, Huddinge, Sweden.
    Stenvinkel, Peter
    Karolinska Univ Hosp, Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Huddinge, Sweden.
    Wennberg, Lars
    Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Transplantat Surg, Huddinge, Sweden.
    Supek, Fran
    Barcelona Inst Sci & Technol, Genome Data Sci, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain;ICREA, Barcelona, Spain.
    Eriksson, Maria
    Karolinska Inst, Ctr Innovat Med, Dept Biosci & Nutr, Huddinge, Sweden.
    Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type2019In: Genome Biology, ISSN 1465-6906, E-ISSN 1474-760X, Vol. 20, no 1, article id 285Article in journal (Refereed)
    Abstract [en]

    Background: The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of somatic mutation patterns, based on both types and genomic distribution of variants, can shed light on specific processes active in different human tissues and their effect on the transition to cancer. Results: To analyze somatic mutation patterns, we compile a comprehensive genetic atlas of somatic mutations in healthy human cells. High-confidence variants are obtained from newly generated and publicly available whole genome DNA sequencing data from single non-cancer cells, clonally expanded in vitro. To enable a well-controlled comparison of different cell types, we obtain single genome data (92% mean coverage) from multi-organ biopsies from the same donors. These data show multiple cell types that are protected from mutagens and display a stereotyped mutation profile, despite their origin from different tissues. Conversely, the same tissue harbors cells with distinct mutation profiles associated to different differentiation states. Analyses of mutation rate in the coding and non-coding portions of the genome identify a cell type bearing a unique mutation pattern characterized by mutation enrichment in active chromatin, regulatory, and transcribed regions. Conclusions: Our analysis of normal cells from healthy donors identifies a somatic mutation landscape that enhances the risk of tumor transformation in a specific cell population from the kidney proximal tubule. This unique pattern is characterized by high rate of mutation accumulation during adult life and specific targeting of expressed genes and regulatory regions.

  • Sun, Song
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada;.
    Weile, Jochen
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Verby, Marta
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Wu, Yingzhou
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Wang, Yang
    Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA;Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA 02115 USA.
    Cote, Atina G.
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Fotiadou, Iosifina
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Kitaygorodsky, Julia
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Vidal, Marc
    Dana Farber Canc Inst, CCSB, Boston, MA 02215 USA;Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA 02115 USA.
    Rine, Jasper
    Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA;Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA.
    Jesina, Pavel
    Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague 12808 2, Czech Republic;Gen Univ Hosp Prague, Prague 12808 2, Czech Republic.
    Kozich, Viktor
    Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague 12808 2, Czech Republic;Gen Univ Hosp Prague, Prague 12808 2, Czech Republic.
    Roth, Frederick P.
    Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada;Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase2020In: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 12, no 1, article id 13Article in journal (Refereed)
    Abstract [en]

    Background For the majority of rare clinical missense variants, pathogenicity status cannot currently be classified. Classical homocystinuria, characterized by elevated homocysteine in plasma and urine, is caused by variants in the cystathionine beta-synthase (CBS) gene, most of which are rare. With early detection, existing therapies are highly effective. Methods Damaging CBS variants can be detected based on their failure to restore growth in yeast cells lacking the yeast ortholog CYS4. This assay has only been applied reactively, after first observing a variant in patients. Using saturation codon-mutagenesis, en masse growth selection, and sequencing, we generated a comprehensive, proactive map of CBS missense variant function. Results Our CBS variant effect map far exceeds the performance of computational predictors of disease variants. Map scores correlated strongly with both disease severity (Spearman's rho = 0.9) and human clinical response to vitamin B-6 (rho = 0.93). Conclusions We demonstrate that highly multiplexed cell-based assays can yield proactive maps of variant function and patient response to therapy, even for rare variants not previously seen in the clinic.

  • Ljungvall, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Rhodin, Annika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Wagner, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Zetterberg, Hedvig
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Åsenlöf, Pernilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    "My life is under control with these medications": an interpretative phenomenological analysis of managing chronic pain with opioids2020In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 21, article id 61Article in journal (Refereed)
    Abstract [en]

    Background: The use of opioids to relieve chronic pain has increased during the last decades, but experiences of chronic opioid therapy (COT) (> 90 days) point at risks and loss of beneficial effects. Still, some patients report benefits from opioid medication, such as being able to stay at work. Guidelines for opioid use in chronic pain do not consider the individual experience of COT, including benefits and risks, making the first person perspective an important scientific component to explore. The aim of this study was to investigate the lived experience of managing chronic pain with opioids in a sample who have severe chronic pain but are able to manage their pain sufficiently to remain at work.

    Methods: We used a qualitative research design: interpretative phenomenological analysis. Ten individuals with chronic pain and opioid therapy were purposively sampled in Swedish tertiary care.

    Results: Three super-ordinate themes emerged from the analyses: Without opioids, the pain becomes the boss; Opioids as a salvation and a curse, and Acknowledgement of the pain and acceptance of opioid therapy enables transition to a novel self. The participants used opioids to regain control over their pain, thus reclaiming their wanted life and self, and sense of control over one's life-world. Using opioids to manage pain was not unproblematic and some of the participants had experienced a downward spiral of escalating pain and uncontrollable opioid use, and stigmatisation.

    Conclusions: All participants emphasised the importance of control, regarding both pain and opioid use. To accomplish this, trust between participants and health care providers was essential for satisfactory treatment. Regardless of the potential sociocultural benefits of staying at work, participants had experiences of balancing positive and negative effects of opioid therapy, similar to what previous qualitative research has found. Measurable improvement of function and quality of life, may justify the long-term use of opioids in some cases. However, monitoring of adverse events should be mandatory. This requires close cooperation and a trusting relationship between the patients and their health care provider.

  • Sibley, Chris G.
    et al.
    Univ Auckland, Auckland, New Zealand.
    Bergh, Robin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Satherley, Nicole
    Univ Auckland, Auckland, New Zealand.
    Osborne, Danny
    Univ Auckland, Auckland, New Zealand.
    Milojev, Petar
    Univ Auckland, Auckland, New Zealand.
    Greaves, Lara M.
    Univ Auckland, Auckland, New Zealand.
    Huang, Yanshu
    Univ Auckland, Auckland, New Zealand.
    Townrow, Carly S.
    Univ Auckland, Auckland, New Zealand.
    Faapoi, Amy
    Univ Auckland, Auckland, New Zealand.
    Yogeeswaran, Kumar
    Univ Canterbury, Christchurch, New Zealand.
    Hawi, Diala
    Doha Inst Grad Studies, Doha, Qatar.
    Duckitt, John
    Univ Auckland, Auckland, New Zealand.
    Profiling authoritarian leaders and followers2019In: TPM - Testing, Psychometrics, Methodology in Applied Psychology, ISSN 1972-6325, Vol. 26, no 3, p. 401-417Article in journal (Refereed)
    Abstract [en]

    Research has long suggested that there may be distinct subpopulations of authoritarian leaders and followers within the broader population. We describe a latent profile analysis of right-wing authoritarianism (RWA) and social dominance orientation (SDO) in a New Zealand national probability sample (N = 18,248) that - for the first time - reliably identifies these two types. Consistent with the positive correlation between SDO and RWA, most people in New Zealand (about 91.2%) expressed comparable levels of RWA and SDO (i.e., moderate-moderate or low-low, but no high-high profile). Two small and distinct subpopulations diverted from this pattern, instead fitting a high-SDO/low-RWA authoritarian leader (1.2%) or low-SDO/high-RWA authoritarian follower (7.6%) profile. Authoritarian leaders tended to show the least concern for human rights, and were least willing to make personal sacrifices for the environment, but tended to support same-sex marriage, while authoritarian followers were particularly opposed to same-sex marriage, and yet highly supportive of human rights. These two profiles represent distinct subpopulations of people within society who are predisposed to seek dominance over others and those predisposed to unquestioningly follow them.

  • Perchiazzi, Gaetano
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hedenstierna laboratory. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Wrigge, Hermann
    Univ Hosp Leipzig, Dept Anesthesiol & Intens Care Med, D-04103 Leipzig, Germany;Bergmannstrost Hosp Halle, Dept Anesthesiol Intens Care & Emergency Med Pain, D-06112 Halle, Germany.
    Acute Respiratory Distress Syndrome (ARDS): Pathophysiological Insights and Lung Imaging2019In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, no 12, article id 2171Article in journal (Other academic)
    Abstract [en]

    Acute respiratory distress syndrome (ARDS) is in the center of the scientific debate both for its complex pathophysiology and for the discussion about the remedies that could contribute to its healing. The intricate interplay of different body systems that characterizes ARDS is mirrored by two main research threads, one centered on the pathophysiological mechanisms of the disease and the other on the new approaches to lung imaging. In this Special Issue of the Journal of Clinical Medicine are presented studies using imaging technologies based on electrical impedance tomography, synchrotron radiation computed tomography and intravital probe-based confocal laser endomicroscopy. The studies on the pathophysiological mechanisms pertain to the evaluation of the biomarkers of the disease and the platelet disfunction during extracorporeal membrane oxygenation. These contributions witness the intensity of ARDS research as many of the key problems of the disease are only in part resolved.

  • Hagström, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Ander, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Cernvall, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Ljótsson, Brjánn
    Division of Psychology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Wiman, Henrik W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    von Essen, Louise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Woodford, Joanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Psychology in Healthcare.
    Heeding the psychological concerns of young cancer survivors: A single-arm feasibility trial of CBT and a cognitive behavioral conceptualization of distress2020In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 8, article id e8714Article in journal (Refereed)
    Abstract [en]

    Background

    A subgroup of adolescent and young adult (AYA) survivors of cancer during adolescence report high levels of psychological distress. To date, evidence-based psychological interventions tailored to the cancer-related concerns experienced by this population are lacking. The present study aimed to (1) examine the feasibility and preliminary efficacy of an individualized cognitive behavioral therapy (CBT) intervention for AYA survivors of cancer during adolescence; and (2) identify and conceptualize cancer-related concerns as well as maintaining factors using cognitive-behavioral theory.

    Methods

    A single-arm trial, whereby AYA survivors of cancer during adolescence (aged 17–25 years) were provided individualized face-to-face CBT at a maximum of 15 sessions. Clinical outcomes were assessed at baseline, post-intervention, and three-month follow-up. Intervention uptake, retention, intervention delivery, and reliable change index scores were examined. An embedded qualitative study consisted of two unstructured interviews with each participant pre-intervention. Along with individual behavioral case formulations developed to guide the intervention, interview data was analyzed to identify and conceptualize cancer-related concerns and potential maintaining factors.

    Results

    Ten out of 213 potential participants invited into the study were included, resulting in an overall participation rate of 4.7%. Nine participants completed the intervention, with respectively seven and eight participants completing the post-intervention and three month follow-up assessment. The majority of reported cancer-related concerns and maintaining factors were conceptualized into four themes: social avoidance, fear of emotions and bodily symptoms, imbalance in activity, and worry and rumination.

    Conclusions

    Given significant recruitment difficulties, further research is required to examine barriers to help-seeking in the AYA cancer survivor population. However, the conceptualization of cancer-related concerns and maintaining factors experienced by the population may represent an important first step in the development of psychological support tailored toward AYA cancer survivors’ unique needs.

  • Hulsart Billström, Gry
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Stelzl, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Procter, Philip
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Pujari-Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Insley, Gerard
    GPBio Ltd, Unit 4D, Western Business Pk, Shannnon, Clare, Ireland.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science and Engineering, Applied Material Science.
    Larsson, Sune
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    In vivo safety assessment of a bio-inspired bone adhesive2020In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 31, no 2, article id 24Article in journal (Refereed)
    Abstract [en]

    A new class of materials, bone adhesives, could revolutionise the treatment of highly fragmented fractures. We present the first biological safety investigation of a bio-inspired bone adhesive. The formulation was based upon a modified calcium phosphate cement that included the amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable calcium phosphate cements. Four adhesive groups with the active substance (phosphoserine) and two control groups without phosphoserine were selected for in vitro and in vivo biocompatibility testing. The test groups were subject for cell viability assay and subcutaneous implantation in rats that was followed by gene expression analysis and histology assessment after 6 and 12 weeks. All adhesive groups supported the same rate of cell proliferation compared to the alpha-TCP control and had viability between 45-64% when compared to cell control. There was no evidence of an increased immune response or ectopic bone formation in vivo. To conclude, this bio-inspired bone adhesive has been proven to be safe, in the present study, without any harmful effects on the surrounding soft tissue. 

  • Melkersson, Kristina
    et al.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Wernroth, Lisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Type 1 diabetes mellitus and the risk for schizophrenia or schizoaffective disorder: a Swedish nationwide register-based cohort study2019In: Neuro - endocrinology letters, ISSN 0172-780X, Vol. 40, no 3, p. 125-134Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Type 1 diabetes mellitus (T1DM), resulting from an immune-associated destruction of insulin-secreting pancreatic beta-cells, has been reported in a few earlier studies to be inversely associated with schizophrenia, but not with schizophrenia-like psychoses. The aim of this study was to verify this finding by carrying out a Swedish register study.

    METHODS: Data from the Total Population- and Medical Birth-Registers were used to create a cohort of all individuals born in Sweden 1987-2004. The cohort individuals were linked with the Inpatient- and Outpatient-Registers and followed from birth to 2017 to identify onset of T1DM, schizophrenia and schizoaffective disorder. Cox proportional hazard regression models were used to assess the association between T1DM and risk of developing schizophrenia or schizoaffective disorder during a follow-up from age 13.

    RESULTS: The study population included 1 745 977 individuals and the length of follow-up was maximally 18.0 (median 9.7) years. During the follow-up, 1 280 individuals developed schizophrenia and 649 individuals schizoaffective disorder. The risk of developing schizophrenia was significantly lower among individuals with, than among individuals without, a diagnosis of T1DM, whereas the risk of developing schizoaffective disorder did not differ among individuals with or without a T1DM diagnosis [adjusted hazard ratio (95% confidence interval); schizophrenia: 0.29 (0.09-0.91), p=0.0338, schizoaffective disorder: 1.50 (0.71-3.16), p=0.29091].

    CONCLUSIONS: This study, in line with previous studies, shows that a diagnosis of T1DM is associated with a decreased risk of schizophrenia. This finding of an inverse association between T1DM and schizophrenia may bring an interesting piece, related to autoimmunity, into the schizophrenia-aetiology puzzle.

  • Söderbäck, Hanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The "warming war": Securitizing climate change at the UN Security Council2020Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of this study was to explore the discursive strategies involved when representatives of small island developing States (SIDS) attempt to securitize climate change in the Security Council, in order to understand which, if any, discursive strategies are successful, and if the securitizing attempt itself is successful. The theoretical framework is based on securitization theory as developed by the Copenhagen school, and the material for the analysis is made up of four meeting records from meetings of the Security Council, ranging from 2007 until 2019. The method chosen to carry out the analysis was discourse analysis. The study found three discursive strategies that were used by the representatives of SIDS; "climate change as a conventional threat"; "climate change and moral responsibility"; and "climate change as an encompassing threat". The study ultimately found that the securitizing attempt was partially successful. 

  • Christensson, Victoria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Civil society and peace - a holy relationship?: A case study on the role of faith-based organizations in peacebuilding and their promotion of human rights in Colombia.2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This master thesis deals with civil society peacebuilding and human rights, aiming to explore the relationship between these perspectives. In more detail, the peacebuilding functions of the Colombian faith-based network of DiPaz are examined in a context where the Government of Colombia and the FARC guerilla have signed a peace agreement and officially entered a postconflict phase, and to realize the examination the comprehensive framework of Thania Paffenholz and Christoph Spurk (2010) is used. Moreover, a human rights perspective on the functions is applied in order to examine the possibilities of using the agendas of peacebuilding and human rights simultaneously with that purpose of working towards a sustainable peace in Colombia. The conclusion is that the framework is useful when examining the relationship between civil society and peacebuilding, and that the peacebuilding functions of DiPaz are of relevance. Finally, a human rights agenda is frequently used simultaneously by DiPaz to promote the respect of human rights and sustainable peace.

  • Altai, Mohamed
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Garousi, Javad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Rinne, Sara S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Schulga, Alexey
    Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia.
    Deyev, Sergey
    Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia;Natl Res Tomsk Polytech Univ, Tomsk, Russia;Sechenov Univ, Ctr BioMed Engn, Moscow, Russia.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Natl Res Tomsk Polytech Univ, Tomsk, Russia.
    On the prevention of kidney uptake of radiolabeled DARPins2020In: EJNMMI Research, ISSN 2191-219X, E-ISSN 2191-219X, Vol. 10, article id 7Article in journal (Refereed)
    Abstract [en]

    Background: Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14-18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPins labeled with residualizing labels is a limitation for targeted radionuclide therapy. A better understanding of the mechanisms behind the kidney uptake of DARPins could aid the development of strategies to reduce it. In this study, we have investigated whether the renal uptake of [Tc-99m]Tc(CO)(3)-G3 DARPin could be reduced by administration of compounds that act on various parts of the reabsorption system in the kidney.

    Results: Co-injection of lysine or Gelofusine was not effective for the reduction of kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Administration of sodium maleate before the injection of [Tc-99m]Tc(CO)(3)-G3 reduced the kidney-associated activity by 60.4 +/- 10.3%, while administration of fructose reduced it by 46.9 +/- 7.6% compared with the control. The decrease in the kidney uptake provided by sodium maleate was also observed for [Tc-99m]Tc(CO)(3)-9_29 DARPin. Preinjection of colchicine, probenecid, mannitol, or furosemide had no effect on the kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Kidney autoradiography showed mainly cortical accumulation of activity for all studied groups.

    Conclusion: Common clinical strategies were not effective for the reduction of kidney uptake of [Tc-99m]Tc(CO)(3)-G3. Both fructose and maleate lower the cellular ATP level in the proximal tubule cells and their reduction of the kidney reuptake indicates the involvement of an ATP-driven uptake mechanism. The decrease provided by maleate for both G3 and 9_29 DARPins indicates that their uptake proceeds through a mechanism independent of DARPin structure and binding site composition.

  • Ren, Zhengyong
    et al.
    Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Peoples R China.
    Kalscheuer, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Uncertainty and Resolution Analysis of 2D and 3D Inversion Models Computed from Geophysical Electromagnetic Data2020In: Surveys in geophysics, ISSN 0169-3298, E-ISSN 1573-0956, Vol. 41, no 1, p. 47-112Article in journal (Refereed)
    Abstract [en]

    A meaningful solution to an inversion problem should be composed of the preferred inversion model and its uncertainty and resolution estimates. The model uncertainty estimate describes an equivalent model domain in which each model generates responses which fit the observed data to within a threshold value. The model resolution matrix measures to what extent the unknown true solution maps into the preferred solution. However, most current geophysical electromagnetic (also gravity, magnetic and seismic) inversion studies only offer the preferred inversion model and ignore model uncertainty and resolution estimates, which makes the reliability of the preferred inversion model questionable. This may be caused by the fact that the computation and analysis of an inversion model depend on multiple factors, such as the misfit or objective function, the accuracy of the forward solvers, data coverage and noise, values of trade-off parameters, the initial model, the reference model and the model constraints. Depending on the particular method selected, large computational costs ensue. In this review, we first try to cover linearised model analysis tools such as the sensitivity matrix, the model resolution matrix and the model covariance matrix also providing a partially nonlinear description of the equivalent model domain based on pseudo-hyperellipsoids. Linearised model analysis tools can offer quantitative measures. In particular, the model resolution and covariance matrices measure how far the preferred inversion model is from the true model and how uncertainty in the measurements maps into model uncertainty. We also cover nonlinear model analysis tools including changes to the preferred inversion model (nonlinear sensitivity tests), modifications of the data set (using bootstrap re-sampling and generalised cross-validation), modifications of data uncertainty, variations of model constraints (including changes to the trade-off parameter, reference model and matrix regularisation operator), the edgehog method, most-squares inversion and global searching algorithms. These nonlinear model analysis tools try to explore larger parts of the model domain than linearised model analysis and, hence, may assemble a more comprehensive equivalent model domain. Then, to overcome the bottleneck of computational cost in model analysis, we present several practical algorithms to accelerate the computation. Here, we emphasise linearised model analysis, as efficient computation of nonlinear model uncertainty and resolution estimates is mainly determined by fast forward and inversion solvers. In the last part of our review, we present applications of model analysis to models computed from individual and joint inversions of electromagnetic data; we also describe optimal survey design and inversion grid design as important applications of model analysis. The currently available model uncertainty and resolution analyses are mainly for 1D and 2D problems due to the limitations in computational cost. With significant enhancements of computing power, 3D model analyses are expected to be increasingly used and to help analyse and establish confidence in 3D inversion models.