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  • da Cruz, Vinicius Vaz
    et al.
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.
    Ignatova, Nina
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Siberian Fed Univ, Krasnoyarsk 660041, Russia;Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
    Couto, Rafael C.
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden.
    Fedotov, Daniil A.
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Siberian Fed Univ, Krasnoyarsk 660041, Russia.
    Rehn, Dirk R.
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden.
    Savchenko, Viktoriia
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Siberian Fed Univ, Krasnoyarsk 660041, Russia;Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
    Norman, Patrick
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden.
    Ågren, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden.
    Polyutov, Sergey
    Siberian Fed Univ, Krasnoyarsk 660041, Russia;Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
    Niskanen, Johannes
    Univ Turku, Dept Phys & Astron, FI-20014 Turun, Finland;Helmholtz Zentrum Berlin Mat & Energie, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Eckert, Sebastian
    Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.
    Jay, Raphael M.
    Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.
    Fondell, Mattis
    Helmholtz Zentrum Berlin Mat & Energie, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Schmitt, Thorsten
    Paul Scherrer Inst, Photon Sci Div, CH-5232 Villigen, Switzerland.
    Pietzsch, Annette
    Helmholtz Zentrum Berlin Mat & Energie, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Foehlisch, Alexander
    Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany;Helmholtz Zentrum Berlin Mat & Energie, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Gel'mukhanov, Faris
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Siberian Fed Univ, Krasnoyarsk 660041, Russia;Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
    Odelius, Michael
    Stockholm Univ, AlbaNova Univ Ctr, Dept Phys, S-10691 Stockholm, Sweden.
    Kimberg, Victor
    KTH Royal Inst Technol, Dept Theoret Chem & Biol, S-10691 Stockholm, Sweden;Siberian Fed Univ, Krasnoyarsk 660041, Russia;Fed Res Ctr KSC SB RAS, Kirensky Inst Phys, Krasnoyarsk 660036, Russia.
    Nuclear dynamics in resonant inelastic X-ray scattering and X-ray absorption of methanol2019In: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, Vol. 150, no 23, article id 234301Article in journal (Refereed)
    Abstract [en]

    We report on a combined theoretical and experimental study of core-excitation spectra of gas and liquid phase methanol as obtained with the use of X-ray absorption spectroscopy (XAS) and resonant inelastic X-ray scattering (RIXS). The electronic transitions are studied with computational methods that include strict and extended second-order algebraic diagrammatic construction [ADC(2) and ADC(2)-x], restricted active space second-order perturbation theory, and time-dependent density functional theory-providing a complete assignment of the near oxygen K-edge XAS. We show that multimode nuclear dynamics is of crucial importance for explaining the available experimental XAS and RIXS spectra. The multimode nuclear motion was considered in a recently developed "mixed representation" where dissociative states and highly excited vibrational modes are accurately treated with a time-dependent wave packet technique, while the remaining active vibrational modes are described using Franck-Condon amplitudes. Particular attention is paid to the polarization dependence of RIXS and the effects of the isotopic substitution on the RIXS profile in the case of dissociative core-excited states. Our approach predicts the splitting of the 2a RIXS peak to be due to an interplay between molecular and pseudo-atomic features arising in the course of transitions between dissociative core- and valence-excited states. The dynamical nature of the splitting of the 2a peak in RIXS of liquid methanol near pre-edge core excitation is shown. The theoretical results are in good agreement with our liquid phase measurements and gas phase experimental data available from the literature. (C) 2019 Author(s).

  • Lakka, Antti
    et al.
    Aalto Univ, Dept Elect & Nanoengn, Espoo, Finland.
    Pulkkinen, Tuija I.
    Aalto Univ, Dept Elect & Nanoengn, Espoo, Finland;Univ Michigan, Dept Climate & Space Sci & Engn, Ann Arbor, MI 48109 USA.
    Dimmock, Andrew P.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Kilpua, Emilia
    Univ Helsinki, Dept Phys, Helsinki, Finland.
    Ala-Lahti, Matti
    Univ Helsinki, Dept Phys, Helsinki, Finland.
    Honkonen, Ilja
    Finnish Meteorol Inst, Helsinki, Finland.
    Palmroth, Minna
    Univ Helsinki, Dept Phys, Helsinki, Finland.
    Raukunen, Osku
    Univ Turku, Dept Phys & Astron, Turku, Finland.
    GUMICS-4 analysis of interplanetary coronal mass ejection impact on Earth during low and typical Mach number solar winds2019In: Annales Geophysicae, ISSN 0992-7689, E-ISSN 1432-0576, Vol. 37, no 4, p. 561-579Article in journal (Refereed)
    Abstract [en]

    We study the response of the Earth's magnetosphere to fluctuating solar wind conditions during interplanetary coronal mass ejections (ICMEs) using the Grand Unified Magnetosphere-Ionosphere Coupling Simulation (GUMICS-4). The two ICME events occurred on 15-16 July 2012 and 29-30 April 2014. During the strong 2012 event, the solar wind upstream values reached up to 35 particles cm(-3), speeds of up to 694 km s(-1), and an interplanetary magnetic field of up to 22 nT, giving a Mach number of 2.3. The 2014 event was a moderate one, with the corresponding upstream values of 30 particles cm(-3), 320 km s(-1) and 10 nT, indicating a Mach number of 5.8. We examine how the Earth's space environment dynamics evolves during both ICME events from both global and local perspectives, using well-established empirical models and in situ measurements as references. We show that on the large scale, and during moderate driving, the GUMICS-4 results are in good agreement with the reference values. However, the local values, especially during high driving, show more variation: such extreme conditions do not reproduce local measurements made deep inside the magnetosphere. The same appeared to be true when the event was run with another global simulation. The cross-polar cap potential (CPCP) saturation is shown to depend on the Alfven-Mach number of the upstream solar wind. However, care must be taken in interpreting these results, as the CPCP is also sensitive to the simulation resolution.

  • Hoarfrost, Adrienne
    et al.
    Univ N Carolina, Dept Marine Sci, Chapel Hill, NC 27515 USA;Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA.
    Balmonte, John Paul
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Univ N Carolina, Dept Marine Sci, Chapel Hill, NC 27515 USA.
    Ghobrial, Sherif
    Univ N Carolina, Dept Marine Sci, Chapel Hill, NC 27515 USA.
    Ziervogel, Kai
    Univ New Hampshire, Inst Study Earth Oceans & Space, Durham, NH 03824 USA.
    Bane, John
    Univ N Carolina, Dept Marine Sci, Chapel Hill, NC 27515 USA.
    Gawarkiewicz, Glen
    Woods Hole Oceanog Inst, Dept Phys Oceanog, Woods Hole, MA 02543 USA.
    Arnosti, Carol
    Univ N Carolina, Dept Marine Sci, Chapel Hill, NC 27515 USA.
    Gulf Stream Ring Water Intrusion on the Mid-Atlantic Bight Continental Shelf Break Affects Microbially Driven Carbon Cycling2019In: Frontiers in Marine Science, E-ISSN 2296-7745, Vol. 6, article id 394Article in journal (Refereed)
    Abstract [en]

    Warm core, anticyclonic rings that spin off from the Gulf Stream circulate through the region directly offshore of the Mid-Atlantic Bight. If a warm core ring reaches the continental shelf break, its warm, highly saline water may subduct under cooler, fresher continental shelf surface water, resulting in subsurface waters at the shelf break and over the upper continental slope with high temperatures and salinities and distinct physical and chemical properties characteristic of Gulf Stream water. Such intruding water may also have microbial communities with distinct functional capacities, which may in turn affect the rate and nature of carbon cycling in this coastal/shelf environment. However, the functional capabilities of microbial communities within ring intrusion waters relative to surrounding continental shelf waters are largely unexplored. We investigated microbial community capacity to initiate organic matter remineralization by measuring hydrolysis of a suite of polysaccharide, peptide, and glucose substrates along a transect oriented across the Mid-Atlantic Bight shelf, shelf break, and upper slope. At the outermost sampling site, warm and salty water derived from a Gulf Stream warm core ring was present in the lower portion of the water column. This water exhibited hydrolytic capacities distinct from other sampling sites, and exhibited lower heterotrophic bacterial productivity overall. Warm core rings adjacent to the Mid-Atlantic Bight shelf have increased in frequency and duration in recent years. As the influence of warm core rings on the continental shelf and slope increases in the future, the rate and nature of organic matter remineralization on the continental shelf may also shift.

  • Douchi, Damien
    et al.
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Liang, Feiyan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Cano, Melissa
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Xiong, Wei
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Wang, Bo
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Maness, Pin-Ching
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Lindblad, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Yu, Jianping
    Natl Renewable Energy Lab, Biosci Ctr, Golden, CO 80401 USA.
    Membrane-Inlet Mass Spectrometry Enables a Quantitative Understanding of Inorganic Carbon Uptake Flux and Carbon Concentrating Mechanisms in Metabolically Engineered Cyanobacteria2019In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 1356Article in journal (Refereed)
    Abstract [en]

    Photosynthesis uses solar energy to drive inorganic carbon (Ci) uptake, fixation, and biomass formation. In cyanobacteria, Ci uptake is assisted by carbon concentrating mechanisms (CCM), and CO2 fixation is catalyzed by RubisCO in the Calvin-Benson-Bassham (CBB) cycle. Understanding the regulation that governs CCM and CBB cycle activities in natural and engineered strains requires methods and parameters that quantify these activities. Here, we used membrane-inlet mass spectrometry (MIMS) to simultaneously quantify Ci concentrating and fixation processes in the cyanobacterium Synechocystis 6803. By comparing cultures acclimated to ambient air conditions to cultures transitioning to high Ci conditions, we show that acclimation to high Ci involves a concurrent decline of Ci uptake and fixation parameters. By varying light input, we show that both CCM and CBB reactions become energy limited under low light conditions. A strain over-expressing the gene for the CBB cycle enzyme fructose-bisphosphate aldolase showed higher CCM and carbon fixation capabilities, suggesting a regulatory link between CBB metabolites and CCM capacity. While the engineering of an ethanol production pathway had no effect on CCM or carbon fixation parameters, additional fructose-bisphosphate aldolase gene over-expression enhanced both activities while simultaneously increasing ethanol productivity. These observations show that MIMS can be a useful tool to study the extracellular Ci flux and how CBB metabolites regulate Ci uptake and fixation.

  • Ahi, Ehsan Pashay
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology. Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
    Richter, Florian
    Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
    Lecaudey, Laurene Alicia
    Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
    Sefc, Kristina M.
    Karl Franzens Univ Graz, Inst Biol, Univ Pl 2, A-8010 Graz, Austria.
    Gene expression profiling suggests differences in molecular mechanisms of fin elongation between cichlid species2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 9052Article in journal (Refereed)
    Abstract [en]

    Comparative analyses of gene regulation inform about the molecular basis of phenotypic trait evolution. Here, we address a fin shape phenotype that evolved multiple times independently across teleost fish, including several species within the family Cichlidae. In a previous study, we proposed a gene regulatory network (GRN) involved in the formation and regeneration of conspicuous filamentous elongations adorning the unpaired fins of the Neolamprologus brichardi. Here, we tested the members of this network in the blockhead cichlid, Steatocranus casuarius, which displays conspicuously elongated dorsal and moderately elongated anal fins. Our study provided evidence for differences in the anatomy of fin elongation and suggested gene regulatory divergence between the two cichlid species. Only a subset of the 20 genes tested in S. casuarius showed the qPCR expression patterns predicted from the GRN identified in N. brichardi, and several of the gene-by-gene expression correlations differed between the two cichlid species. In comparison to N. brichardi, gene expression patterns in S. casuarius were in better (but not full) agreement with gene regulatory interactions inferred in zebrafish. Within S. casuarius, the dorsoventral asymmetry in ornament expression was accompanied by differences in gene expression patterns, including potential regulatory differentiation, between the anal and dorsal fin.

  • Joffer, Junia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Umea Univ, Dept Epidemiol & Global Hlth, SE-90187 Umea, Sweden.
    Flacking, Renee
    Dalarna Univ, Sch Educ Hlth & Social Studies, SE-79188 Falun, Sweden.
    Bergstrom, Erik
    Umea Univ, Dept Clin Sci, Pediat, SE-90187 Umea, Sweden.
    Randell, Eva
    Dalarna Univ, Sch Educ Hlth & Social Studies, SE-79188 Falun, Sweden.
    Jerdén, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Umea Univ, Dept Epidemiol & Global Hlth, SE-90187 Umea, Sweden;Dalarna Univ, Sch Educ Hlth & Social Studies, SE-79188 Falun, Sweden.
    Self-rated health, subjective social status in school and socioeconomic status in adolescents: a cross-sectional study2019In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 19, article id 785Article in journal (Refereed)
    Abstract [en]

    BackgroundSocial position, traditionally measured by objective data on socioeconomic status (SES), is linked to health status in adults. In adolescents, the association is more uncertain and there are some studies suggesting that subjective social status (SSS) might be more adequate in relation to health. This study aimed to examine associations between SSS in school, SES and self-rated health (SRH) in adolescent boys and girls.MethodsA descriptive cross-sectional research design with quantitative survey data was used. The study involved 705 Swedish adolescents in upper secondary school (17-18-year-olds). SRH was measured with a single-item question and SSS by a question where adolescents were asked to assess their social position within their school. Formal education level of the parents was used as a proxy for objective SES. Univariable and multivariable ordinal regression analyses were conducted to assess the associations between SRH and SSS in school and SES.ResultsIn the multivariable analysis, SSS in school was positively associated with SRH, whereas no significant association between SES and SRH was found. The proportion of adolescents with high SRH increased with higher steps on the SSS ladder. Significant gender differences were found in that boys rated their SRH and SSS in school higher than girls did.ConclusionsThe study shows that self-rated health in adolescents is related to perceived social position in school. Subjective social status in school seems to be a useful health-related measure of social position in adolescents.

  • Parducci, Laura
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Alsos, Inger Greve
    Univ Tromso, Arctic Univ Norway, Tromso Museum, Tromso, Norway.
    Unneberg, Per
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pedersen, Mikkel W.
    Univ Cambridge, Dept Zool, Cambridge, England.
    Han, Lu
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics. Jilin Univ, Ancient DNA Lab, Coll Life Sci, Changchun, Jilin, Peoples R China.
    Lammers, Youri
    Univ Tromso, Arctic Univ Norway, Tromso Museum, Tromso, Norway.
    Salonen, J. Sakari
    Univ Helsinki, Dept Geosci & Geog, Helsinki, Finland.
    Valiranta, Minna M.
    Univ Helsinki, Ecosyst & Environm Res Programme, ECRU, Helsinki, Finland.
    Slotte, Tanja
    Stockholm Univ, Dept Ecol Environm & Plant Sci, Stockholm, Sweden;Sci Life Lab, Solna, Sweden.
    Wohlfarth, Barbara
    Stockholm Univ, Dept Geol Sci, Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    Shotgun Environmental DNA, Pollen, and Macrofossil Analysis of Lateglacial Lake Sediments From Southern Sweden2019In: Frontiers in Ecology and Evolution, E-ISSN 2296-701X, Vol. 7, article id 189Article in journal (Refereed)
    Abstract [en]

    The lake sediments of Hasseldala Port in south-east Sweden provide an archive of local and regional environmental conditions similar to 14.5-9.5 ka BP (thousand years before present) and allow testing DNA sequencing techniques to reconstruct past vegetation changes. We combined shotgun sequencing with plant micro- and macrofossil analyses to investigate sediments dating to the Allerod (14.1-12.7 ka BP), Younger Dryas (12.7-11.7 ka BP), and Preboreal (<11.7 ka BP). Number of reads and taxa were not associated with sample age or organic content. This suggests that, beyond the initial rapid degradation, DNA is still present. The proportion of recovered plant DNA was low, but allowed identifying an important number of plant taxa, thus adding valid information on the composition of the local vegetation. Importantly, DNA provides a stronger signal of plant community changes than plant micro- and plant macrofossil analyses alone, since a larger number of new taxa were recorded in Younger Dryas samples. A comparison between the three proxies highlights differences and similarities and supports earlier findings that plants growing close to or within a lake are recorded by DNA. Plant macrofossil remains moreover show that tree birch was present close to the ancient lake since the Allerod; together with the DNA results, this indicates that boreal to subarctic climatic conditions also prevailed during the cold Younger Dryas interval. Increasing DNA reference libraries and enrichment strategies prior to sequencing are necessary to improve the potential and accuracy of plant identification using the shotgun metagenomic approach.

  • Moberg, Simon
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Artificial photosynthesis - 4-Aminobenzoic acids effect on charge transfer in a photo catalytic system2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Artificial photosynthesis is used to harvest solar energy and store it in the form of chemical bonds. The system of interest in this study does this by splitting water into hydrogen and oxygen gas through a plasmon assisted process, collective oscillations from free electron gas. This is a renewable way to store energy that could be used as an alternative to fossil based fuel. In this study, a small part of this photo catalytic system is studied, namely the interaction between plasmonically active silver nanoparticles (Ag NPs) transferring photo-excited electrons via a linker molecule, 4-aminobenzoic acid (pABA). The pABA linker molecule transfers charge from the Ag surface to a semiconductor and a catalyst performing the water splitting. The pABA can bind in different ways onto the Ag-surface and the aim of this study is to examine which bond is strongest and which best enables charge transfer. To this purpose three systems where simulated quantum mechanically using a supercomputer. The total free energy of the systems was computed and compared. Out of the three studied binding sites, the hollow-site bond (pABA binding to three silver atoms) was found to have the lowest energy, meaningit's the strongest of the possible bonds. Additionally it was found that the band gap (the energy needed to transfer charge) for the pABA decreased when bound to the Ag-surface. The hollow-site bound pABA also had the smallest band gap, meaning it requires the least energy to transfer a charge and should therefore be the best bond fitted for the photo catalytic system.

  • Asfaw, Harnet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Division of Pharmacokinetics and Drug Therapy.
    Undersökning av samtal om läkemedelsinteraktioner inkomna till Läkemedelsupplysningen på Läkemedelsverket.2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Introduktion: Läkemedelsinteraktion uppstår vid samtidig behandling med flera läkemedel som påverkar varandras effekter. Interaktioner uppkommer inte endast vid samtidig behandling av flera receptbelagda läkemedel. Även natur- och receptfria läkemedel, vissa födoämnen exempelvis grapefruktjuice och kalkhaltiga livsmedel som mjölkprodukter samt alkohol kan ge upphov till interaktioner. Läkemedel påverkar varandras effekter genom farmakokinetiska och farmakodynamiska processer. Läkemedelupplysningen är en upplysningstjänst på Läkemedelverket och har som uppdrag att förmedla information om läkemedelsanvändning till allmänheten. Frågorna varierar och handlar ofta om läkemedels möjliga säkerhetsrisker t.ex. interaktioner och biverkningar.

    Syfte: Syftet med denna studie var att sortera och analysera inkomna frågor till LMU för att ta reda på vilken information som efterfrågas om interaktioner.Metod: Undersökning genomfördes utifrån kvalitativa och kvantitativa perspektiv och Microsoft Excel-dokument innehållande all information om bland annat läkemedelsinteraktioner inkomma till LMU användes.

    Resultat: Undersökningen visade att 25% av alla frågor inkomna till LMU handlade om läkemedelsinteraktioner. Resultatet visade att de flesta frågor handlade om läkemedelsinteraktioner mellan läkemedel för nervsystemet blodtrycks- och blodförtunnade mediciner. Kategorisering för egenvårdsprodukter resulterade i att frågeställarna i de flesta fall frågar om deras receptbelagda läkemedel fungerar ihop med receptfria produkter som smärtstillande NSAID, paracetamol protonpumpshämmare samt vitaminkosttillkott. Validering av ett antal frågor visade i stort sett rätt kategorisering.

    Konklusion: Resultatet visar att allmänheten har stora behov av information om läkemedelsinteraktioner om läkemedel för nervsystemet, blodtrycks- och blodförtunnade mediciner och egenvårdsprodukter bl.a. smärtstillande läkemedel.

  • Enberg, Rikard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Är universum och naturlagarna permanenta?2019In: Annales Academiae regiae scientiarum Upsaliensis : Kungl. Vetenskapssamhällets i Uppsala årsbok, ISSN 0504-0736, Vol. 42, p. 49-61Article in journal (Other academic)
  • Lindahl, Isabell
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Hilowle, Samira
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Viktor, Karlsson
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Gustaf, Kåreceus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    An investigation of aspects affecting availability and grading of high-risk antibiotics in Sweden.: Group 32019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this report is to investigate aspects affectingavailability and grade high-risk antibiotics in Sweden. 10antibiotics out of 39 antibiotics compiled by the Swedish PublicHealth Authority were studied according to the factors; class(based on chemical structure), industrial production process,number of API manufacturers found, the geographic location of the API manufacturers, number of MAH found in Sweden, number of MAH found in the EEA, number of backorders in Sweden, total length of backorders, currently not provided in Sweden (Number of MAH), assumed profitability per product, uncertainty in annual sales

    volume (relative standard deviation), uncertainty in annual sales (relative standard deviation), average sales (High/Low) and lastly parallel import to Sweden. The same factors were studied for the remaining 29 antibiotics by group 1 and 2 in order to compile a final grading with the parameters high, medium and low. A grading system was constructed to facilitate the grading system. Itresulted in nine antibiotics graded high, 23 antibiotics graded medium and lastly seven antibiotics were graded low. Also, out of the nine antibiotics formulated as tablets, five were graded ashigh. This drew the conclusion that a correlation between high- risk antibiotics and tablet formulation could be made. Another correlation made was that beta-lactam antibiotics were overrepresented in the antibiotics rated as high. There was also a slight overrepresentation of antibiotics formulated as injection/infusion in the low-risk category. A few limitations occurred during the process of the project such as the research for API manufacturers only included the ones approved in the EEA and the U.S. The grading of the antibiotics assigned to Group 1 and 2 was based only on the tables received from these groups, excluding additional details that may have affected the finalgrading. Nevertheless, the project conceived variation in theresult previously compiled by the Swedish Public Health Authority.

  • Trembczyk, Max
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Answer Triggering Mechanisms in Neural Reading Comprehension-based Question Answering Systems2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    We implement a state-of-the-art question answering system based on Convolutional Neural Networks and Attention Mechanisms and include four different variants of answer triggering that have been discussed in recent literature. The mechanisms are included in different places in the architecture and work with different information and mechanisms.

    We train, develop and test our models on the popular SQuAD data set for Question Answering based on Reading Comprehension that has in its latest version been equipped with additional non-answerable questions that have to be retrieved by the systems. We test the models against baselines and against each other and provide an extensive evaluation both in a general question answering task and in the explicit performance of the answer triggering mechanisms.

    We show that the answer triggering mechanisms all clearly improve the model over the baseline without answer triggering by as much as 19.6% to 31.3% depending on the model and the metric. The best performance in general question answering shows a model that we call Candidate:No, that treats the possibility that no answer can be found in the document as just another answer candidate instead of having an additional decision step at some place in the model's architecture as in the other three mechanisms.

    The performance on detecting the non-answerable questions is very similar in three of the four mechanisms, while one performs notably worse. We give suggestions which approach to use when a more or less conservative approach is desired, and discuss suggestions for future developments.

  • Radon, Jenny
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    FILADE TÄNDER I ljuset av sina sammanhang: En studie av individer med modifierade tänder i Skandinavien under yngre järnålder2019Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    This master thesis investigates the phenomenon of men with filed (modified) teeth in Scandinavia during late Iron Age. More than 100 buried men with filed teeth have up till now been discovered. Of these, 92 are included in my analysis. Burials containing men with filed teeth have been discovered on Gotland, in Skåne, Uppland, Västergötland and Öland in Sweden, on Fyn in Denmark and in one mass grave in Dorset, England. Most of the men derive from burials on Gotland.

     

    The men with filed teeth have hitherto mostly been studied from an osteoarchaeological approach. Instead, this study regards the burial contexts in which they were found. In order to study this, I have compiled a data base in which available information about these men and their burial contexts have been gathered. The term ¨burial context¨ in this essay refers to the grave finds and the aspects of the burial itself, as well as the landscape in which it is situated.

     

    The aim of the study is to try to determine what unites, and separates, the men with filed teeth; what can be said about the dating of their occurrence, the men’s origin/provenance and what social status and occupation they may have held. 

  • Malinyerno, Matteo
    et al.
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Maderna, Claudio
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Abu Taha, Abdallah
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Corada, Monica
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Orsenigo, Fabrizio
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Valentino, Mariaelena
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Pisati, Federica
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Cogentech Scarl, Histopathol Unit, I-20139 Milan, Italy.
    Fusco, Carmela
    Fdn IRCCS Casa Sollievo Sofferenza, Div Med Genet, I-71013 Foggia, Italy.
    Graziano, Paolo
    Fdn IRCCS Casa Sollievo Sofferenza, Pathol Unit, I-71013 Foggia, Italy.
    Giannotta, Monica
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy.
    Yu, Qing Cissy
    Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.
    Zeng, Yi Arial
    Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.
    Lampugnani, Maria Grazia
    FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Mario Negri Inst Pharmacol Res, I-20156 Milan, Italy.
    Magnusson, Peetra U.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Dejana, Elisabetta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. FIRC Inst Mol Oncol Fdn, Vasc Biol Unit, I-20139 Milan, Italy;Univ Milan, Sch Med, Dept Oncol & Haematooncol, I-20122 Milan, Italy.
    Endothelial cell clonal expansion in the development of cerebral cavernous malformations2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 2761Article in journal (Refereed)
    Abstract [en]

    Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes. Familial CCM follows a two-hit mechanism similar to that of tumour suppressor genes, while in sporadic cavernomas only a small fraction of endothelial cells shows mutated CCM genes. We reported that in mouse models and in human patients, endothelial cells lining the lesions have different features from the surrounding endothelium, as they express mesenchymal/stem-cell markers. Here we show that cavernomas originate from clonal expansion of few Ccm3-null endothelial cells that express mesenchymal/stem-cell markers. These cells then attract surrounding wild-type endothelial cells, inducing them to express mesenchymal/stem-cell markers and to contribute to cavernoma growth. These characteristics of Ccm3-null cells are reminiscent of the tumour-initiating cells that are responsible for tumour growth. Our data support the concept that CCM has benign tumour characteristics.

  • Holm, Mikael
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Mandava, Chandra Sekhar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
    Ehrenberg, Måns
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
    Sanyal, Suparna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.
    The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation2019In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e46124Article in journal (Refereed)
    Abstract [en]

    Applying pre-steady state kinetics to an Escherichia-coli-based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading. We find that viomycin binds to translating ribosomes associated with a ternary complex (TC) consisting of elongation factor Tu (EF-Tu), aminoacyl tRNA and GTP, and locks the otherwise dynamically flipping monitoring bases A1492 and A1493 into their active conformation. This effectively prevents dissociation of near- and non-cognate TCs from the ribosome, thereby enhancing errors in initial selection. Moreover, viomycin shuts down proofreading-based error correction. Our results imply a mechanism in which the accuracy of initial selection is achieved by larger backward rate constants toward TC dissociation rather than by a smaller rate constant for GTP hydrolysis for near- and non-cognate TCs. Additionally, our results demonstrate that translocation inhibition, rather than error induction, is the major cause of cell growth inhibition by viomycin.

  • Gunnesson, Matilda
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik. 1996.
    Åkelid, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Framtidens byggproduktion: deponifri: En kartläggning av framgångsfaktorer för minskat byggavfall till deponi inom nyproduktion2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This technical report contains a study of the construction industries work regarding landfill waste. More specifically Sweden’s and the company Skanska’s development to prevent landfill and fulfill an ecofriendly society. The construction companies in Sweden are accountable for over a third of the country’s total waste and are prioritized to improve their statistics. Skanska have a goal to reach zero percent landfill waste, therefor should all the construction material be able to reuse or recycle.

    The purpose of this study is to find the causes and background of the landfill waste and to identify the factors of success. The goal is to give recommendations to Skanska on how they progressively can phase out landfill waste.

    The content of the report is built from a background part where the general challenge and goals is explained. Thereafter are the methods for information acquisition, interview study and literature study explained along with some typical landfill material and how it can be reused or recycled. A few projects are listed under chapter four to give the reader an understanding for what the authors have been looking at. Lastly the report will take the reader through the study’s results, discussion and recommendations.

    The results show that some recycling methods are available for the fractions which usually ends up as landfill. But the requirements for recycling and reuse are often too hard to fulfill in the construction industries. The interviews show that a high commitment is necessary for a highly qualified work with the landfill waste.

    Future projects are recommended to early on identify material that easily becomes landfill and avoid them as much as possible. Use smaller bins where there is less space and work continently with waste plans.

  • Härd, Johan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics.
    Skoglund, Mårten
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics.
    Trafikbelastade gårdsbjälklag: En undersökning av beräkningsmetoders lämplighet och möjliga förenklingar i projekteringsprocessen2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    As a structural designer, you are sometimes required to design structures carrying traffic loads, but which are not, for example, bridges or parking garages. In practice, this usually applies to drivable floor layers and culverts under roads. When designing structures such as bridges and parking garages, there are clear standards and regulations to follow. These types of guidelines are not as comprehensive when it comes specifically to dimensioning traffic-load-bearing constructions in connection with building construction. Frequently, an evenly distributed load of 20 kN/m2 is used.

    The purpose of this work is to investigate which regulations house construction designers should relate to when designing structures that carry traffic loads which are not bridges or parking garages. The work also includes an investigation of how suitable different calculation methods are for different types of load cases. The goal is to make recommendations that can streamline the work for construction designers.

    The material for this work has been obtained through three different methods. In order to gain an understanding of the subject and the current state of knowledge in the field, a literature study has been made. The main part of the work has included qualitative interviews with people who have good experience and knowledge in the field, as well as practical modeling and calculation of load cases. The focus has been on investigating which transverse forces occur for some specific load cases. The study also includes the effect of the fill layer’s thickness on the load spread.

    For larger floor spans, it is confirmed that an evenly distributed load of 20 kN/m2 is a bit heaped. To dimension after this covers most of the load cases that may occur on a floor layer or similar construction. In some cases, this value could be halved without problem. It also turns out that the shorter the span of the floor, the more the evenly distributed load differs between the different fill layer thicknesses. 

  • Möllerberg, Erik
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Tingelöf, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Intern kommunikation inom uppdragsprocessen2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Projects in the construction sector, whether it is of newconstructions or renovations, is a process that includes severaldisciplines that must interact. To facilitate collaborationthere are many different methods and tools for communication. Thisreport aims to create an understanding of the problems thatBjerking, a consulting company in the construction design sector,today has with the internal communication, or if there even isa problem, and to examine solutions to improve communication. Inorder to obtain data, Bjerking employees from Uppsala and Stockholmwere interviewed and a customer who has a far-reaching frameworkagreement with Bjerking. A survey was also sent out to all450 employees at Bjerking. Other secondary data on groupdevelopment, interviewing techniques and more were obtained inliterature through the network library Legimus and the databaseDiva. The results of interviews and the survey show that there isa problem with how communication takes place and that there is adissatisfaction with the handling of documents. The presentedproposals for improvements are based on the shortcomings that existin the communication that emerged in the interview study and thesurvey. These proposals include third-party file management andchatbased communication systems. They will influence how dailycommunication and internal communication within projects take place.This in turn can affect the project’s quality and timeconsumtion.Although Bjerking already has a communication tool, it isprimarily the project that decides on how the work should be done.However, one should be consistent in the choice of communicationtools internally. Proposals for a minor restructuring of thetemplates and control documents presented on Bjerking’s intranetare presented. Proposals concerning project numbering and access todocuments aswell.Finally, recommendations and further studies are presented whereconcrete proposals about which communication system is best suitedto Bjerking and what the next step to increase the efficiency is.

  • Hu, Xuchen
    et al.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Matsumoto, Ken
    VIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium.
    Jung, Rachel S.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Weston, Thomas A.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Heizer, Patrick J.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    He, Cuiwen
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Sandoval, Norma P.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Allan, Christopher M.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Tu, Yiping
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Vinters, Harry V.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.
    Liau, Linda M.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, JCCC, Los Angeles, CA 90095 USA.
    Ellison, Rochelle M.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Morales, Jazmin E.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Baufeld, Lynn J.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA.
    Bayley, Nicholas A.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA.
    He, Liqun
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Betsholtz, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Huddinge, Sweden.
    Beigneux, Anne P., I
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Nathanson, David A.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA.
    Gerhardt, Holger
    VIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium;Max Delbruck Ctr Mol Med, Berlin, Germany.
    Young, Stephen G.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
    Fong, Loren G.
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
    Jian, Haibo
    Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Western Australia, Sch Mol Sci, Perth, WA, Australia.
    GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients2019In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e47178Article in journal (Refereed)
    Abstract [en]

    GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1-LPL complex is crucial for the generation of lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent from the capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in the capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We use NanoSIMS imaging to show that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells.

  • Arousell, Jonna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Maternal and Reproductive Health and Migration.
    Carlbom, Aje
    Malmo Univ, Fac Hlth & Soc, S-20506 Malmo, Sweden.
    Johnsdotter, Sara
    Malmo Univ, Fac Hlth & Soc, S-20506 Malmo, Sweden.
    Essén, Birgitta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Maternal and Reproductive Health and Migration.
    Are 'low socioeconomic status' and 'religiousness' barriers to minority women's use of contraception?: A qualitative exploration and critique of a common argument in reproductive health research2019In: Midwifery, ISSN 0266-6138, E-ISSN 1532-3099, Vol. 75, p. 59-65Article in journal (Refereed)
    Abstract [en]

    Objective: 'Low socioeconomic status' and 'religiousness' appear to have gained status as nearly universal explanatory models for why women in minority groups are less likely to use contraception than other women in the Scandinavian countries. Through interviews with pious Muslim women with immigrant background, living in Denmark and Sweden, we wanted to gain empirical insights that could inform a discussion about what 'low socioeconomic status' and 'religiousness' might mean with regard to women's reproductive decisions.

    Design: Semi-structured interviews were conducted in Denmark and Sweden between 2013 and 2016.

    Findings: We found that a low level of education and a low income were not necessarily obstacles for women's use of contraception; rather, these were strong imperatives for women to wait to have children until their life circumstances become more stable. Arguments grounded in Islamic dictates on contraception became powerful tools for women to substantiate how it is religiously appropriate to postpone having children, particularly when their financial and emotional resources were not yet established.

    Conclusion: We have shown that the dominant theory that 'low socioeconomic status' and 'religiousness' are paramount barriers to women's use of contraception must be problematized. When formulating suggestions for how to provide contraceptive counseling to women in ethnic and religious minority groups in Denmark and Sweden, one must also take into account that factors such as low financial security as well as religious convictions can be strong imperatives for women to use contraception.

    Implications for practice: This study can help inform a critical discussion about the difficulties of using broad group-categorizations for understanding individuals' health-related behavior, as well as the validity of targeted interventions towards large heterogeneous minority groups in Scandinavian contraceptive counseling.

  • Bengtsson, Stefan L.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, SWEDESD - The Swedish International Centre of Education for Sustainable Development.
    Engaging with the Beyond-Diffracting Conceptions of T-Learning2019In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 11, no 12, article id 3430Article in journal (Refereed)
    Abstract [en]

    This paper develops a theory of transgressive learning (t-learning) as it was experimented with in the International Science Council t-learning network. The method applied is a diffractive reading of conceptions of transgression in academic publications emerging from different cases. The results show that there can be no definite conduct to or understanding of transgression, as transgression itself entails a subversion of rules, contexts, and borders. Instead, the results document several overarching categorical positions and axiomatic understandings of transgression that emerge from the background of context-specific wicked sustainability issues. Transgressive learning can be understood as a set of contextually diverse techniques and practices that attempt to bring about change through and in learning. Transgressive learning can result in experiential learning excesses where the excess is the very source of difference and makes change possible. The diversity of conceptions of transgressive learning open up new entry points for engaging with sustainability-oriented learning and education that is open to change rather than to reproducing unsustainable social structures and dynamics.

  • Kourtit, Karima
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography. JADS, Smart Cities & Data Analyt Lab, NL-5211 Shertogenbosch, Netherlands;KTH Royal Inst Technol, Ctr Future Places CFP, S-11428 Stockholm, Sweden;Adam Mickiewicz Univ, Inst Socioecon Geog & Spatial Management, PL-61712 Poznan, Poland;Alexandru Ioan Cuza Univ, Ctr European Studies, Iasi 700506, Romania;Mohammed VI Polytech Univ, Sch Architecture Planning & Design, Ben Guerir 43150, Morocco.
    Nijkamp, Peter
    JADS, Smart Cities & Data Analyt Lab, NL-5211 Shertogenbosch, Netherlands;Adam Mickiewicz Univ, Inst Socioecon Geog & Spatial Management, PL-61712 Poznan, Poland;Alexandru Ioan Cuza Univ, Ctr European Studies, Iasi 700506, Romania;Mohammed VI Polytech Univ, Sch Architecture Planning & Design, Ben Guerir 43150, Morocco.
    Romao, Joao
    Mohammed VI Polytech Univ, Sch Architecture Planning & Design, Ben Guerir 43150, Morocco;Univ Algarve, Ctr Adv Studies Management & Econ CEFAGE UALG, P-8005139 Faro, Portugal.
    Cultural Heritage Appraisal by Visitors to Global Cities: The Use of Social Media and Urban Analytics in Urban Buzz Research2019In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 11, no 12, article id 3470Article in journal (Refereed)
    Abstract [en]

    An attractive cultural heritage is an important magnet for visitors to many cities nowadays. The present paper aims to trace the constituents of the destination attractiveness of 40 global cities from the perspective of historical-cultural amenities, based on a merger of extensive systematic databases on these cities. The concept of cultural heritage buzz is introduced to highlight: (i) the importance of a varied collection of urban cultural amenities; (ii) the influence of urban cultural magnetism on foreign visitors, residents and artists; and (iii) the appreciation for a large set of local historical-cultural amenities by travelers collected from a systematic big data set (emerging from the global TripAdvisor platform). A multivariate and econometric analysis is undertaken to validate and test the quantitative picture of the above conceptual framework, with a view to assess the significance of historical-cultural assets and socio-cultural diversity in large urban agglomerations in the world as attraction factors for visitors. The results confirm our proposition on the significance of urban cultural heritage as a gravity factor for destination choices in international tourism in relation to a high appreciation for historical-cultural amenities.

  • Vorobyeva, Anzhelika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Schulga, Alexey
    Russian Acad Sci, Mol Immunol Lab, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.
    Rinne, Sara S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Günther, Tyran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Deyev, Sergey
    Russian Acad Sci, Mol Immunol Lab, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia;Natl Res Nucl Univ MEPhI, Inst Engn Phys Biomed PhysBio, Bionanophoton Lab, Moscow 115409, Russia;Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Nucl Med Dept, Tomsk 634050, Russia.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging2019In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 12, article id 3047Article in journal (Refereed)
    Abstract [en]

    Radionuclide molecular imaging of human epidermal growth factor receptor 2 (HER2) in breast and gastroesophageal cancer might be used to stratify patients for HER2-targeted therapy as well as monitor treatment response and disease progression. Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins with favorable properties for molecular imaging. Herein we compared two methods for labeling the anti-HER2 DARPin (HE)(3)-G3, direct and indirect radioiodination. We hypothesized that the use of N-succinimidyl-para-iodobenzoate (SPIB) for radioiodination would facilitate the clearance of radiometabolites and improve the contrast of imaging. Both radiolabeled (HE)(3)-G3 variants preserved their binding specificity and high affinity to HER2-expressing cells. The specificity of tumor targeting in vivo was also demonstrated. A biodistribution comparison of [I-125]I-(HE)(3)-G3 and [I-125]I-PIB-(HE)(3)-G3, in mice bearing HER2 expressing SKOV3 xenografts, showed rapid clearance of [I-125]I-PIB-(HE)(3)-G3 from normal organs and tissues and low accumulation of activity in organs with NaI-symporter expression. Both radiolabeled (HE)(3)-G3 variants had equal tumor uptake. Consequently, the indirect label provided higher tumor-to-blood and tumor-to-organ ratios compared with the direct label. Comparative Single Photon Emission Computed Tomography (SPECT)/CT imaging of HER2 expression in SKOV3 xenografts, using both radiolabeled DARPins, demonstrated the superior imaging contrast of the indirect label. Indirect radioiodination of (HE)(3)-G3 using SPIB could be further applied for SPECT and PET imaging with iodine-123 and iodine-124.

  • Strandberg-de Bruijn, Paulien
    et al.
    Lund Univ, Div Bldg Mat, S-22100 Lund, Sweden.
    Donarelli, Anna
    Swedish Natl Heritage Board, S-62122 Visby, Sweden.
    Balksten, Kristin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History, Conservation.
    Full-scale Studies of Improving Energy Performance by Renovating Historic Swedish Timber Buildings with Hemp-lime2019In: Applied Sciences, E-ISSN 2076-3417, Vol. 9, no 12, article id 2484Article in journal (Refereed)
    Abstract [en]

    With an increased focus on reducing greenhouse gas emissions, energy saving is of great importance in all sectors of society. EU directives set targets for member states to reduce energy use in buildings. Energy saving in historic buildings requires special measures, balancing energy-saving renovations against the preservation of heritage values. Traditional constructions are open to vapor diffusion and generally work differently from modern constructions. Modern materials in traditional constructions sometimes damages the original material as they are usually diffusion-tight. The aim of this study was to investigate whether hemp-lime could be used as an insulation material to improve the energy efficiency of historic timber building envelopes with a rendered facade in Sweden. The objective was to determine the actual energy savings for space heating. An additional objective was to determine the actual thermal transmittance and to study thermal buffering through in-situ measurements in a full-scale wall renovated with hemp-lime. Two full-scale wall sections were constructed at the Energy and Building Design laboratory at Lund University: A traditional post-and-plank wall with a lime render (80 mm), and a post-and-plank wall with a hemp-lime render (90 mm). Energy use for space heating was monitored continuously over a period of one year. The wall with a hemp-lime render required 33% less energy for space heating than the traditional post-and-plank wall with a lime render. This was accomplished without changing the framework, appearance or material in the render and without drastically changing the hygric properties of the facade. From the gathered data, the thermal transmittance (U-values) for both walls was calculated using two different methods, one based on material properties and the other based on energy use data. For both walls, thermal transmittance based on actual energy use data during the heating period was lower than what was expected from their material properties. This indicates that more material properties than thermal conductivity and material thickness need to be taken into account when performing energy use calculations. With hemp-lime, a renovation can be accomplished without damaging the timber structure and wooden slats, and it can be done with local traditional materials and building methods with no difference in appearance to a traditional lime render. This allows for heritage values to be preserved, while also allowing the building to comply with modern standards and with increased thermal comfort and reduced energy use.

  • Lundqvist, Therese
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy.
    Faktorer som påverkar implementering av evidensbaserade program i primärvård – Chefers uppfattning2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • Arlestrand, Kamilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Vad sjunger barnen och varför?: En studie av barnkörledares val av repertoar inom Svenska kyrkan2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Svenska kyrkan har en stark musiktradition, en tradition som historiskt sträcker sig ända tillbaka till gammaltestamentlig tid. Det är rimligt att utgå från att barn deltog med sång redan i de första kristna församlingarna. I dagens svenskkyrkliga församlingar finns vanligtvis ett stort utbud av körer. Barnkören finns med som en självklar och viktig del av kyrkans verksamhet.

    Syftet med uppsatsen är att ge en bild av vad som kan bidra till de repertoarval barnkörledare gör inom ramen för Svenska kyrkans barnkörsarbete. För att uppnå studiens syfte har fyra intervjuer med erfarna barnkörledare genomförts och därefter analyserats med en hermeneutisk metod. Intervjumetoden som använts är den kvalitativa forskningsintervjun med en halvstrukturerad form.1Tonvikten på intervjupersonens upplevelser av ämnet har varit viktig. Intervjuerna föregicks av en webbaserad enkät. Enkäten kom att ligga till grund för de kommande intervjuerna.

    Resultatet av studien visar att de intervjuade körledarna har stor frihet i sina val av repertoar. Styr-och policydokument inom Svenska kyrkan centralt, samt i de lokala församlingarna, saknar riktlinjer vad gäller synen på repertoar för barnkörerna. Det visade sig även att körledarnas utbildning i väldigt liten utsträckning har präglat hur de idag arbetar och förhåller sig till repertoarfrågan.Barnkörledarnas val av repertoar visar sig snarare ta avstamp i kyrkoåret och dess berättelser. Körledarnas egna barnkörserfarenheter och det kollegiala lärandet visar sig vara grunden för hur körledarna utformar sitt arbete och förhåller sig till de många aspekter som påverkar repertoarvalet de gör för sin barnkörer.

  • Melin, Tim
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Morphology of electrodeposited Na on Al electrodes2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The demand for alternative secondary batteries to lithium-ion batteries (LIBs) grows. Sodium-ion batteries (SIBs) have been studied for many years and could replace LIBsfor some application. Metallic anodes for both LIBs and SIBs are interesting due totheir high energy densities. Several aspects such as reactivity, stability and depositionmorphology must be properly addressed before metallic Na could be considered apossible anode material. This study aims to evaluate deposition of Na on Alelectrodes using fundamental electrochemical theories. Na deposition was studiedusing pouch cells and sodium triflate (NaOTf) in dimethyl glycol ether (diglyme) aselectrolyte. Galvanostatic deposition using different current densities, electrolyteconcentrations and potential pulses prior to galvanostatic deposition were tested. Theelectrochemical methods used in this study were galvanostatic deposition andchronoamperometry. The morphology of deposited Na was analyzed with ex-situscanning electron microscopy (SEM). A decrease of the size of deposited Na islandswas observed for both increasing current density and decreasing electrolyteconcentration. Fluctuations and poor stability in the deposition potential wereobtained when decreasing the electrolyte concentration under 0.5 M and also whenincreasing the current density over 1 mA cm-2. The most homogeneous depositionwas obtained with a 1030 ms potential pulse amplitude (-3 V vs. Na+/Na) prior togalvanostatic deposition (1 mA cm-2, 0.5 mAh cm-2) using 0.1 M NaOTf in diglyme aselectrolyte. Reproducibility was a major issue in this study and further investigation ofseveral parameters is needed.

  • Rep, Marco
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Musicology.
    Blue Eyes, Lacanian Real: A psychoanalytic reading of Gustav Mahler’s Lieder eines fahrenden Gesellen2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Gustav Mahler’s Lieder eines fahrenden Gesellen (first published 1887) feature as their only character a miserable wayfarer who laments his unrequited love for someone and who, in spite of all his beautiful pastoral surroundings, cannot help but feel deep unhappiness. Using Lacan’s three orders (Imaginary, Symbolic and Real) and further developments of his theory by Slavoj Žižek in The Sublime Object of Ideology, I argue that the eyes of the wayfarer’s beloved are the Lacanian Real that disrupts his symbolic network and thus are the origin of his traumatic existence. His misery becomes an immanent part of his identity and he can therefore only exist through this feeling. Furthermore I suggest that, although he laments the situation, he subconsciously desires the unhappy love affair as a way of guaranteeing his own existence as a wayfarer, in accordance with Freud’s concept of Repetition compulsion.

  • Zhu, Wei
    et al.
    Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China;Peking Union Med Coll, Beijing 100730, Peoples R China.
    Ma, Qi
    Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China;Peking Union Med Coll, Beijing 100730, Peoples R China.
    Borg, Sebastian
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Öhman Mägi, Caroline
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Weng, Xisheng
    Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China;Peking Union Med Coll, Beijing 100730, Peoples R China.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Cemented injectable multi-phased porous bone grafts for the treatment of femoral head necrosis2019In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 7, no 18, p. 2997-3006Article in journal (Refereed)
    Abstract [en]

    Femoral head necrosis (FHN) can induce musculoskeletal disability. It presents a challenge from diagnostic and therapeutic points of view. Open surgery for the treatment of FHN is not an optimal route. To minimize the surgery window, an injectable material with a porous structure and bioactive nature is preferred. The fabrication of an injectable porous bone graft via a simple route was the aim of our study. Therefore, cemented multi-phased calcium phosphate porous granules have been studied with varied phase compositions, pore sizes and porosities, and degradation rates. Granules templated by PEG 100-600 mu m were chosen for cell toxicity and in vitro osteogenic potential testing. Rabbits, making up a femoral head necrosis model, were implanted with granule A. Mature cancellous bone tissue was observed in the femoral head defect after 2 months implantation. The results indicate that the newly formed injectable bioactive porous grafts could be a good candidate for the treatment of femoral head necrosis.

  • Pullen, Sonja
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics. TU Dortmund Univ, Fac Chem & Chem Biol, Otto Hahn Str 6, D-44227 Dortmund, Germany.
    Maji, Somnath
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics. Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India.
    Stein, Matthias
    Max Planck Inst Dynam Complex Tech Syst, Sandtorstr 2, D-39106 Magdeburg, Germany.
    Ott, Sascha
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Restricted rotation of an Fe(CO)(2)(PL3)-subunit in [FeFe]-hydrogenase active site mimics by intramolecular ligation2019In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 48, no 18, p. 5933-5939Article in journal (Refereed)
    Abstract [en]

    A new series of homodinuclear iron complexes as models of the [FeFe]-hydrogenase active site was prepared and characterized. The complexes of the general formula [Fe-2(mcbdt)(CO)(5)PPh2R] (mcbdt = benzene-1,2-dithiol-3-carboxylic acid) feature covalent tethers that link the mcbdt ligand with the phosphine ligands which are terminally coordinated to one of the Fe centres. The synthetic feasability of the concept is demonstrated with the preparation of three novel complexes. A detailed theoretical investigation showes that by introducing a rigid covalent link between the phosphine and the bridging dithiolate ligands, the rotation of the Fe(CO)(2)P unit is hindered and higher rotation barriers were calculated compared to non-linked reference complexes. The concept of restricting Fe(L)(3) rotation is an approach to kinetically stabilize terminal hydrides which are reactive intermediates in catalytic proton reduction cycles of the enzymes.

  • Iakunkov, Artem
    et al.
    Umea Univ, Dept Phys, S-90187 Umea, Sweden.
    Sun, Jinhua
    Umea Univ, Dept Phys, S-90187 Umea, Sweden.
    Rebrikova, Anastasia
    Moscow MV Lomonosov State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia.
    Korobov, Mikhail
    Moscow MV Lomonosov State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia.
    Klechikov, Alexey
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics. Umea Univ, Dept Phys, S-90187 Umea, Sweden.
    Vorobiev, Alexei
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Boulanger, Nicolas
    Umea Univ, Dept Phys, S-90187 Umea, Sweden.
    Talyzin, Alexandr V.
    Umea Univ, Dept Phys, S-90187 Umea, Sweden.
    Swelling of graphene oxide membranes in alcohols: effects of molecule size and air ageing2019In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 7, no 18, p. 11331-11337Article in journal (Refereed)
    Abstract [en]

    Swelling of Hummers graphene oxide (HGO) membranes in a set of progressively longer liquid alcohols (methanol to 1-nonanol) was studied using synchrotron radiation XRD after air ageing over prolonged periods of time. Both precursor graphite oxides and freshly prepared HGO membranes were found to swell in the whole set of nine liquid alcohols with an increase of interlayer spacing from approximate to 7 angstrom (solvent free) up to approximate to 26 angstrom (in 1-nonanol). A pronounced effect of ageing on swelling in alcohols was found for HGO membranes stored in air. The HGO membranes aged for 0.5-1.5 years show progressively slower swelling kinetics, a non-monotonic decrease of saturated swelling in some alcohols and complete disappearance of swelling for alcohol molecules larger than hexanol. Moreover, the HGO membranes stored under ambient conditions for 5 years showed a nearly complete absence of swelling in all alcohols but preserved swelling in water. In contrast, precursor graphite oxide powder showed unmodified swelling in alcohols even after 4 years of ageing. Since the swelling defines the size of permeation channels, the ageing effect is one of the important parameters which could explain the strong variation in reported filtration/separation properties of GO membranes. The time and conditions of air storage require standardization for better reproducibility of results related to performance of GO membranes in various applications. The ageing of GO membranes can be considered not only as a hindrance/degradation for certain applications, but also as a method to tune the swelling properties of HGO membranes for better selectivity in sorption of solvents and for achieving better selective permeability.

  • Scher, Sebastian
    et al.
    Stockholm Univ, Dept Meteorol, Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    Messori, Gabriele
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Stockholm Univ, Dept Meteorol, Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    Weather and climate forecasting with neural networks: using general circulation models (GCMs) with different complexity as a study ground2019In: Geoscientific Model Development, ISSN 1991-959X, E-ISSN 1991-9603, Vol. 12, no 7, p. 2797-2809Article in journal (Refereed)
    Abstract [en]

    Recently, there has been growing interest in the possibility of using neural networks for both weather forecasting and the generation of climate datasets. We use a bottom-up approach for assessing whether it should, in principle, be possible to do this. We use the relatively simple general circulation models (GCMs) PUMA and PLASIM as a simplified reality on which we train deep neural networks, which we then use for predicting the model weather at lead times of a few days. We specifically assess how the complexity of the climate model affects the neural network's forecast skill and how dependent the skill is on the length of the provided training period. Additionally, we show that using the neural networks to reproduce the climate of general circulation models including a seasonal cycle remains challenging - in contrast to earlier promising results on a model without seasonal cycle.

  • Liu, Wei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Kämpfe Nordström, Charlotta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Danckwardt-Lillieström, Niklas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Rask-Andersen, Helge
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study2019In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 10, article id 728Article in journal (Refereed)
    Abstract [en]

    Background: Like the brain, the human inner ear was long thought to be devoid of immune activity. Only the endolymphatic sac (ES) was known to be endowed with white blood cells that could process antigens and serve as an immunologic defense organ for the entire inner ear. Unexpectedly, the cochlear and vestibular organs, including the eighth cranial nerve, were recently shown to contain macrophages whose functions and implication in ear disease are somewhat undefined. Here, we review recent inner ear findings in man and extend the analyses to the vestibular nerve using super-resolution structured illumination microscopy (SR-SIM).

    Materials and Methods: Human ESs and cochleae were collected during surgery to treat patients with vestibular schwannoma and life-threatening petro-clival meningioma compressing the brainstem. The ESs and cochleae were placed in fixative, decalcified, and rapidly frozen and cryostat sectioned. Antibodies against ionized calcium-binding adaptor molecule 1-expressing cells (IBA1 cells), laminin beta 2 and type IV collagen TUJ1, cytokine fractalkine (CX3CL1), toll-like receptor 4 (TLR4), CD68, CD11b, CD4, CD8, the major histocompatibility complex type II (MHCII), and the microglial marker TEME119 were used.

    Results: IBA1-positive cells were present in the ESs, the cochlea, central and peripheral axons of the cochlear nerve, and the vestibular nerve trunk. IBA1 cells were found in the cochlear lateral wall, spiral limbus, and spiral ganglion. Notable variants of IBA1 cells adhered to neurons with "synapse-like" specializations and cytoplasmic projections. Slender IBA1 cells occasionally protracted into the basal lamina of the Schwann cells and had intimate contact with surrounding axons.

    Discussion: The human eighth nerve may be under the control of a well-developed macrophage cell system. A small number of CD4+ and CD8+ cells were found in the ES and occasionally in the cochlea, mostly located in the peripheral region of Rosenthal's canal. A neuro-immunologic axis may exist in the human inner ear that could play a role in the protection of the auditory nerve. The implication of the macrophage system during disease, surgical interventions, and cell-based transplantation should be further explored.

  • Myhr, Peter
    et al.
    MCT Stockholm, Stockholm, Sweden.
    Hursti, Timo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Emanuelsson, Katarina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Löfgren, Elina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Hjemdal, Odin
    Norwegian Univ Sci & Technol, Dept Psychol, Trondheim, Norway;Nidaros DPS, Div Psychiat, St Clays Hosp, Trondheim, Norway.
    Can the Attention Training Technique Reduce Stress in Students?: A Controlled Study of Stress Appraisals and Meta-Worry2019In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 10, article id 1532Article in journal (Refereed)
    Abstract [en]

    The present study tested the impact of attention training on cognition; secondary appraisal of perceived stress, and on metacognition; meta-worry in stressed students. Theoretically derived from the Self-Regulatory Executive Function model (S-REF model; Wells and Matthews, 1994a, 1996), the attention training technique (ATT; Wells, 1990) is intended to promote flexible, voluntary external attention and has been shown to reduce symptoms of psychological distress. The present experimental study explored the effects of ATT on cognitive and metacognitive levels of appraisal, namely perceived stress (primary outcome) and meta-worry (secondary outcome). Stressed students were randomized to an experimental ATT group (n = 23) or a control group (n = 23). The ATT group attended an initial training session followed by 4 weeks of individual (12 min) daily ATT practice. The control group waited for 4 weeks before receiving the intervention. The outcomes were scores on the Perceived Stress Scale 14 (PSS-14) and the Meta-Worry Questionnaire (MWQ) frequency and belief subscales at post study. Both measures decreased significantly following ATT with large pre- to post-effect sizes but there were minimal changes in the control group. The between-group differences were statistically significant. The results add to the literature on the potential effects of ATT by demonstrating effects on the content of cognitive stress appraisals and on meta-worry in an academic setting in a stressed student sample.

  • Aldén, Liselotte
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ridbäck, Ulrika
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nätverket för vindbruk.
    Ny och pågående vindkraftsforskning i Sverige 2018: En sammanställning av svenska forskningsprogram och publikationer inom vindkraftsområdet2019Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Uppsala universitet Campus Gotland producerar årligen en sammanställning av svensk forskning om vindkraft i serien Ny och pågående forskning om vindkraft i Sverige. Syftet med dessa publikationer är att intresserade ska få en lättillgänglig överblick av vad som skett under året inom vindkraftsforskningen i landet. Sammanställningen är indelad i två avsnitt. Det första är en presentation av de forskningsprogram och forskningscentra som är verksamma inom vindkraftsforskning i Sverige med fokus på deras pågående projekt. Därefter följer en ämnesindelad förteckning över publicerad forskning om vindkraft under aktuellt år vid svenska universitet, högskolor och institutioner. Där ingår vetenskapliga artiklar och rapporter, doktors- och licentiatavhandlingar samt uppsatser på kandidat-, magister- och mastersnivå samt sammanfattningar med statistik och jämförelser med tidigare år.

  • Aurell, Sandra
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Hosp Vastmanland, Dept Ophthalmol, Vasteras, Sweden.
    Sjövall, Kersti
    Hosp Vastmanland, Dept Ophthalmol, Vasteras, Sweden.
    Paul, Anna
    Hosp Vastmanland, Dept Ophthalmol, Vasteras, Sweden.
    Morén, Åsa
    Hosp Vastmanland, Dept Ophthalmol, Vasteras, Sweden.
    Granstam, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Hosp Vastmanland, Dept Ophthalmol, Vasteras, Sweden.
    Better visual outcome at 1 year with antivascular endothelial growth factor treatment according to treat-and-extend compared with pro re nata in eyes with neovascular age-related macular degeneration2019In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 97, no 5, p. 519-524Article in journal (Refereed)
    Abstract [en]

    Purpose: To evaluate treatment outcome at 12 months in eyes with neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) injections according to either pro re nata (PRN)- or treat-and-extend (TE)-regimen in one clinical setting in Sweden.

    Methods: Data were obtained retrospectively from the Swedish Macula Register, optical coherence tomography-database and electronic patient charts. The study included 443 eyes; 223 PRN- and 220 TE-treated eyes. Baseline (BL) characteristics and follow-up data at 6 and 12 months were collected. Statistical regression analysis was performed to evaluate association between treatment strategy and visual outcome at 12 months.

    Results: Baseline (BL) characteristics were well balanced between cohorts. Visual acuity at 12 months was higher in TE-cohort 66.5 (13.1) compared to PRN-cohort 60.1 (17.6) (p = 0.000). Visual improvement at 12 months was +5.2 (11.8) and +1.2 (12.7) letters Early Treatment Diabetic Retinopathy Study (ETDRS) in TE- and PRN-cohorts, respectively (p = 0.002). Number of administered injections at 12 months was 10.2 (2.1) and 6.3 (2.1) in the two cohorts (p = 0.000). Statistical analysis demonstrated a strong association between TE treatment strategy and improvement in visual acuity at 12 months.

    Conclusion: Eyes treated according to TE had better visual outcome at 12 months. The results indicate that treatment according to proactive TE-regimen is superior to treatment according to PRN-regimen in clinical routine care of nAMD.

  • Donczew, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    An Innovative In-Tunnel Seismic Study for Sustainably Extracting Apatite Ore at the Siilinjärvi Mine, Eastern Finland2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Siilinjärvi located in eastern Finland is presently the only phosphate mine with significant phosphorus production in western Europe. Phosphate rock and phosphorus are known as a critical raw material for the European Union due to their economic importance and being prone to the supply risks. Securing their sustainable exploration as well as extraction is hence important. At Siilinjärvi, the phosphate rocks appear within a major Archean alkaline and carbonatite system deformed by several shear zones and intruded by dike systems. By understanding their spatial and temporal relationships an improved exploration and extraction of the ore is possible, which in turn will contribute to the sustainable extraction of this critical material. In October 2018 a novel in-tunnel seismic survey was conducted in the Siilinjärvi open-pit mine. The objective of the study was to employ an in-tunnel seismic survey intersecting several major shear zones running on the eastern side of the main pit, with the idea of characterising its geometry and relationship with the mineralization. The use of the existing mine infrastructure (a water-drainage tunnel) makes the acquisition of the data quite novel in open-pit mines. The water-drainage tunnel nearly in the bottom of the pit crosscutting several major shear zones and dikes was used to enable bench-tunnel seismic data acquisition. High-quality data were acquired using 144 receivers inside the tunnel, with the sources located both inside the tunnel (Bobcat-mounted vertical drophammer) and on the surface (combined explosives and Bobcat-drophammer). Results obtained show at least two reflections interpreted to originate from subvertical shear zones intersecting the tunnel illustrating the importance of such surveys for shear-zone imaging and site characterization. Based on a careful study of a number of shot records, delay in arrival times and partial amplitude lose, these reflections are interpreted to be backscattered surface-waves generated from the shear zones.

  • Staunton, Ciara
    et al.
    Middlesex Univ, Sch Law, London, England;EURAC, Ctr Biomed, Bolzano, Italy.
    Slokenberga, Santa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. Lund Univ, Fac Law, Lund, Sweden.
    Mascalzoni, Deborah
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. EURAC, Ctr Biomed, Bolzano, Italy.
    The GDPR and the research exemption: considerations on the necessary safeguards for research biobanks2019In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 27, no 8, p. 1159-1167Article in journal (Refereed)
    Abstract [en]

    The General Data Protection Regulation (GDPR) came into force in May 2018. The aspiration of providing for a high level of protection to individuals' personal data risked placing considerable constraints on scientific research, which was contrary to various research traditions across the EU. Therefore, along with the set of carefully outlined data subjects' rights, the GDPR provides for a two-level framework to enable derogations from these rights when scientific research is concerned. First, by directly invoking provisions of the GDPR on a condition that safeguards that must include 'technical and organisational measures' are in place and second, through the Member State law. Although these derogations are allowed in the name of scientific research, they can simultaneously be challenging in light of the ethical requirements and wellestablished standards in biobanking that have been set forth in various research-related soft legal tools, international treaties and other legal instruments. In this article, we review such soft legal tools, international treaties and other legal instruments that regulate the use of health research data. We report on the results of this review, and analyse the rights contained within the GDPR and Article 89 of the GDPR vis-a-vis these instruments. These instruments were also reviewed to provide guidance on possible safeguards that should be followed when implementing any derogations. To conclude, we will offer some commentary on limits of the derogations under the GDPR and appropriate safeguards to ensure compliance with standard ethical requirements.

  • von Witting, Emma
    et al.
    KTH Royal Inst Technol, Dept Prot Sci, SE-10691 Stockholm, Sweden.
    Garousi, Javad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Lindbo, Sarah
    KTH Royal Inst Technol, Dept Prot Sci, SE-10691 Stockholm, Sweden.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Altai, Mohamed
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Oroujeni, Maryam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Hober, Sophia
    KTH Royal Inst Technol, Dept Prot Sci, SE-10691 Stockholm, Sweden.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Selection of the optimal macrocyclic chelators for labeling with 111In and 68Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT62019In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 140, p. 109-120Article in journal (Refereed)
    Abstract [en]

    Radionuclide molecular imaging is a promising tool that becomes increasingly important as targeted cancer therapies are developed. To ensure an effective treatment, a molecular stratification of the cancer is a necessity. To accomplish this, visualization of cancer associated molecular abnormalities in vivo by molecular imaging is the method of choice. ADAPTs, a novel type of small protein scaffold, have been utilized to select and develop high affinity binders to different proteinaceous targets. One of these binders, ADAPT6 selectively interacts with human epidermal growth factor 2 (HER2) with low nanomolar affinity and can therefore be used for its in vivo visualization. Molecular design and optimization of labeled anti-HER2 ADAPT has been explored in several earlier studies, showing that small changes in the scaffold affect the biodistribution of the domain. In this study, we evaluate how the biodistribution properties of ADAPT6 is affected by the commonly used maleimido derivatives of the macrocyclic chelators NOTA, NODAGA, DOTA and DOTAGA with the aim to select the best variants for SPECT and PET imaging. The different conjugates were labeled with 111In for SPECT and 68Ga for PET. The acquired data show that the combination of a radionuclide and a chelator for its conjugation has a strong influence on the uptake of ADAPT6 in normal tissues and thereby gives a significant variation in tumor-toorgan ratios. Hence, it was concluded that the best variant for SPECT imaging is 111In-(HE)3DANS-ADAPT6-GSSC-DOTA while the best variant for PET imaging is 68Ga-(HE)3DANS-ADAPT6-GSSC-NODAGA.

  • Dogurevich, Pavel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Kinetic simulation of spherically symmetric collisionless plasma in the inner part of a cometary coma2019Student paper other, 10 credits / 15 HE creditsStudent thesis
  • Robinson, David
    et al.
    Ryhov Hosp, Dept Urol, Jonkoping, Sweden.
    Garmo, Hans
    Regional Cancer Centre Uppsala Örebro, Uppsala university hospital, Sweden;Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England.
    Van Hemelrijck, Mieke
    Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England.
    Damber, Jan-Erik
    Univ Gothenburg, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden.
    Bratt, Ola
    Univ Gothenburg, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden.
    Holmberg, Lars
    Kings Coll London, TOUR, Sch Canc & Pharmaceut Sci, London, England.
    Wahlund, Lars-Olof
    Karolinska Inst, Karolinska Univ Hosp, NVS Dept, Sect Clin Geriatr, Huddinge, Sweden.
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Adolfsson, Jan
    Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.
    Androgen deprivation therapy for prostate cancer and risk of dementia2019In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 124, no 1, p. 87-92Article in journal (Refereed)
    Abstract [en]

    Objectives

    To study whether androgen deprivation therapy (ADT), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia.

    Methods

    Risk of dementia in men with prostate cancer primarily managed with ADT or watchful waiting (WW) in the Prostate Cancer Database Sweden, PCBaSe, was compared with that in prostate cancer-free men, matched on birth year and county of residency. We used Cox regression to calculate the hazard ratios (HRs) for Alzheimer's and non-Alzheimer's dementia (vascular dementia, dementia secondary to other diseases or unspecified dementias) for different types and duration of ADT and oral antiandrogens (AAs) as well as for men managed with WW.

    Results

    A total of 25 967 men with prostate cancer and 121 018 prostate cancer-free men were followed for a median of 4 years. In both groups 6% of the men were diagnosed with dementia. In men with prostate cancer, gonadotropin-releasing hormone agonist treatment ( HR 1.15, 95% confidence interval [CI] 1.07-1.23) and orchiectomy (HR 1.60, 95% CI 1.32-1.93) were associated with an increased risk of dementia, as compared to no treatment in prostate cancer-free men; however, this increase in risk was only observed for non-Alzheimer's dementia and occurred from year 1-4 after start of ADT. No increase in risk for any type of dementia was observed for men treated with AAs or for men on WW.

    Conclusion

    This population-based cohort study does not support previous observations of an increased risk of Alzheimer's dementia for men on ADT; however, there was a small increase in risk of non-Alzheimer's dementia.

  • Nacke, Filip
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Division of Pharmacokinetics and Drug Therapy.
    External validation of a tool to assess medication-related admissions in four Swedish hospitals2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    External validation of a tool to assess medication-related admissions in four Swedish hospitals

    Background

    The MedBridge trial is a large ongoing clinical trial on medication reviews in elderly patients in Sweden with participating hospitals from Uppsala, Enköping, Västerås and Gävle. A tool for assessing medication-related admissions (MRAs) has been developed and validated in Uppsala: Assessment Tool for identifying Hospital Admissions Related to Medications (AT-HARM10). MRAs is often used as an outcome for medication reviews and similar interventions. Validation of AT-HARM10 outside of Uppsala is therefore warranted.

    Aim

    The aim was to externally validate AT-HARM10. This was needed since AT-HARM10 was for the first time used outside Uppsala.

    Materials and methods

    The readmissions of elderly patients within the MedBridge trial were collected from all participating hospitals. The assessors in this study were two final-year pharmacy students. First, the assessors assessed the readmissions independently of each other and then a consensus meeting was held where the readmissions were discussed, and a consensus was reached. The outcomes in this study were the assessment time, inter-rater reliability and content validity between the hospitals from Uppsala, Enköping, Västerås, and Gävle. The time was measured every day during the assessment period. The inter-rater reliability was calculated for every consensus meeting. The content validity was based on the questions from AT-HARM10 and was collected for each of the assessed readmissions and compared between the four participating hospitals. The content validity of the distribution of questions U1-P10 between the hospitals was tested with a χ2-test.

    Results

    In this study, 1687 unplanned readmissions from 893 patients were assessed. Uppsala University Hospital had 6.6 minutes as total mean assessment time including consensus meeting. The total mean time from Enköping, Västerås and Gävle were 6.48, 6.32 and 6.16 minutes respectively. The strength of agreement between the two assessors was substantial in Uppsala, Västerås and Gävle (ĸ 0.80, 0.79 and 0.76 respectively) and perfect in Enköping (ĸ 0.89). For the content validity were there no differences between the hospitals in the distribution of question U1-P10.

    Conclusion

    AT-HARM10 was for the first time used outside Uppsala and has been externally validated with data from the hospitals in Enköping, Västerås, and Gävle. The time needed per admission for the two assessors was low which confirms that it is possible to have final-year pharmacy students as assessors. This information is important both within the MedBridge trial and if the tool would be used in outer clinical studies.

  • Lagerqvist, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Purification of photosystem II for future spectroscopic characterization2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Volkov, Ivan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Seefeldt, A. Carolin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Johansson, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Tracking of single tRNAs for translation kinetics measurements in chloramphenicol treated bacteria2019In: Methods, ISSN 1046-2023, E-ISSN 1095-9130, Vol. 162-163, p. 23-30Article in journal (Refereed)
    Abstract [en]

    Chloramphenicol is a broad-spectrum antibiotic targeting the protein synthesis machinery by binding to the bacterial ribosome. Chloramphenicol has been considered a classic general inhibitor of translation, blocking the accommodation of aa-tRNA into the A site of the large ribosomal subunit. However, recent studies suggest that this proposed mechanism is a simplification and that the effect of chloramphenicol on mRNA translation is much more dynamic. By tracking single dye-labelled elongator and initiator tRNAs in Escherichia coli cells treated with chloramphenicol, we observe the direct effect of chloramphenicol on translation kinetics. We find clear indications of slow but significant mRNA translation on drug bound ribosomes.

  • Östlund, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Influence of pH on the size and shape of micellesformed by an amphiphilic drug in normal salinitystudied with static and dynamic light scattering2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Hagag, Naglaa M.
    et al.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Erfan, Ahmed M.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    El-Husseiny, Mohamed
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Shalaby, Azhar G.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Saif, Mohamed A.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Tawakol, Maram M.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Nour, Ahmed A.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Selim, Abdullah A.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Arafa, Abdel-Satar
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Hassan, Mohamed K.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Hassan, Wafaa M. M.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Fahmy, Hanan A.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Ibraheem, Essam
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Attia, Mohamed
    Gen Org Vet Serv, Nadi El Said St, Cairo 12619, Dokki Giza, Egypt.
    Abdelhakim, Ali M. M.
    Gen Org Vet Serv, Nadi El Said St, Cairo 12619, Dokki Giza, Egypt.
    Shahein, Momtaz A.
    Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Naguib, Mahmoud
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod, 7 Nadi El Seid St, Cairo 12618, Dokki Giza, Egypt.
    Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt2019In: Viruses, ISSN 1999-4915, E-ISSN 1999-4915, Vol. 11, no 6, article id 565Article in journal (Refereed)
    Abstract [en]

    Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.

  • Sjöberg, Josefine
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Coincidences between neutrons and gammas2019Student paper other, 10 HE creditsStudent thesis
    Abstract [en]

    The neutron is a valuable tool in many fields of science due to its properties regarding electric charge and magnetic moment. However, these properties also makes it difficult to detect. Through simulation one can optimize the detector environment to best correspond with the needs for a specific experiment. In this project, a detector environment is simulated, consisting of a neutron and gamma point source and one detector for each type of particle. The simulated results were in good agreement with the underlying theory and the simulation can, therefore, be used in future work.

  • Dreyer, Joshua
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division. The University Centre in Svalbard.
    A detailed study of auroral fragments2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Aurora occurs in various shapes, one of which is the hitherto unreported phenomenon of auroral fragments. For three periods of occurrence of these fragments their properties were studied in detail during this master’s thesis, using mainly ground-based instrumentation located near Longyearbyen on Svalbard, Norway. A base dataset was constructed from 103 all-sky camera images, manually marking 305 fragments for further analysis. This thesis reports and describes the fragment observations during the observed events, including the auroral and geomagnetic context. Fragments generally seem to fall into two categories, the first being singular, apparently randomly distributed fragments, and the second being periodic fragments that occur in groups with a regular spacing close to auroral arcs. A typical fragment has a small horizontal size below 20 km, a short lifetime of less than a minute and shows no field-aligned extent in the emission. The fragments appear mainly west of zenith (73%) during the three observation nights, whereas their north-south distribution is symmetric around the zenith. Almost all of them exhibit westward drift, the estimated speed for one of the fragments passing the field of view of ASK is ∼1 km/s. A spectral signature can be seen in the green auroral wavelength of O at 557.7 nm and red emission line of N2 at 673.0 nm, but no emission enhancement was observed in the blue wavelengths. One fragment passing the EISCAT Svalbard radar’s field of view shows a local ion temperature increase in a small altitude range of ∼15 km, whereas there is no visible increase in electron density. This could be explained by fragment generation due to locally strong horizontal electric fields. A potential mechanism for this might be electric fields of atmospheric waves superposing with the converging electric fields of auroral arcs created by particle precipitation and the corresponding field-aligned currents. The resulting field would be perpendicular to the magnetic field and the auroral arcs, leading to wave-like density variations of excited plasma close to the arcs. Further study is required to verify this hypothesis and improve the understanding of fragment properties determined from the limited dataset used for this thesis.

  • Ferdous, Md Ruknul
    et al.
    IHE Delft Inst Water Educ, Dept Integrated Water Syst & Governance, NL-2611 AX Delft, Netherlands;Univ Amsterdam, Fac Social & Behav Sci, NL-1012 WX Amsterdam, Netherlands.
    Wesselink, Anna
    IHE Delft Inst Water Educ, Dept Integrated Water Syst & Governance, NL-2611 AX Delft, Netherlands.
    Brandimarte, Luigia
    KTH, Dept Sustainable Dev Environm Sci & Engn, SE-10044 Stockholm, Sweden.
    Slager, Kymo
    Deltares, NL-2600 MH Delft, Netherlands.
    Zwarteveen, Margreet
    IHE Delft Inst Water Educ, Dept Integrated Water Syst & Governance, NL-2611 AX Delft, Netherlands;Univ Amsterdam, Fac Social & Behav Sci, NL-1012 WX Amsterdam, Netherlands.
    Di Baldassarre, Giuliano
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. IHE Delft Inst Water Educ, Dept Integrated Water Syst & Governance, NL-2611 AX Delft, Netherlands;CNDS, Ctr Nat Hazards & Disaster Sci, SE-75236 Uppsala, Sweden.
    The Costs of Living with Floods in the Jamuna Floodplain in Bangladesh2019In: Water, ISSN 2073-4441, E-ISSN 2073-4441, Vol. 11, no 6, article id 1238Article in journal (Refereed)
    Abstract [en]

    Bangladeshi people use multiple strategies to live with flooding events and associated riverbank erosion. They relocate, evacuate their homes temporarily, change cropping patterns, and supplement their income from migrating household members. In this way, they can reduce the negative impact of floods on their livelihoods. However, these societal responses also have negative outcomes, such as impoverishment. This research collects quantitative household data and analyzes changes of livelihood conditions over recent decades in a large floodplain area in north-west Bangladesh. It is found that while residents cope with flooding events, they do not achieve successful adaptation. With every flooding, people lose income and assets, which they can only partially recover. As such, they are getting poorer, and therefore less able to make structural adjustments that would allow adaptation in the longer term.

  • Löfgren, André
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Simulations of the inuence of atomic vibrations on the magneticsignal observed in scattering of electron vortex beams on bcc ironcrystal2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis