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  • Wartiainen, Felicia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Who Takes The Lead?: Investigating Leadership In The Climate Change And Human Mobility Nexus2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Leadership has been claimed to be a critical determinant of success and failure in international negotiations. This thesis brings together the study of leadership in multilateral negotiations with the emerging discipline of climate change-induced human mobility. This is done by investigating the prevalence of leadership in the climate change and human mobility nexus, looking at three different actors: the Alliance of Small Island States, Bangladesh and Norway. These actors were analyzed in two different ways: first, by describing how each actor exercise leadership using an analytical framework informed by leadership theories. Second, by investigating whether these actors seem to be recognized as leaders by others, conducting and analyzing a survey from the United Nations Climate Change Conference 2018, COP24. The results indicate that all three actors can be said to exercise leadership in the area of climate change-induced migration, although they exercise leadership in slightly different ways. Out of the three actors that were analyzed, AOSIS was the only actor that seemed to be recognized by others as a leader in the effort to address climate change-induced human mobility.

  • Sortica, Mauricio A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Paneta, Valentina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Bruckner, Barbara
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics. Johannes Kepler Univ Linz, Atom Phys & Surface, A-4040 Linz, Austria.
    Lohmann, Svenja
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Nyberg, Tomas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Bauer, Peter
    Johannes Kepler Univ Linz, Atom Phys & Surface, A-4040 Linz, Austria.
    Primetzhofer, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    On the Z(1)-dependence of electronic stopping in TiN2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 176Article in journal (Refereed)
    Abstract [en]

    We present a thorough experimental study of electronic stopping of H, He, B, N, Ne and Al ions in TiN with the aim to learn about the energy loss mechanisms of slow ions. The energy loss was measured by means of time-of-flight medium-energy ion scattering. Thin films of TiN on silicon with a delta-layer of W at the TiN/Si interface were used as targets. We compare our results to non-linear density functional theory calculations, examining electron-hole pair excitations by screened ions in a free electron gas in the static limit, with a density equivalent to the expected value for TiN. These calculations predict oscillations in the electronic stopping power for increasing atomic number Z(1) of the projectile. An increasing discrepancy between our experimental results and predictions by theory for increasing Z(1) was observed. This observation can be attributed to contributions from energy loss channels different from electron-hole pair excitation in binary Coulomb collisions.

  • Loborg, Matilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Exploring understandings of quality: A study of stakeholder definitions in a university’s internal quality assurance system2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study asks what quality is and according to whom, through exploring the understandings of quality among stakeholders within a university’s internal quality assurance system. The focus is on teachers, students, and policy, as well as the difference between them. A case-study is made of two faculties within Uppsala University, with material based on both semi-structured interviews and text analysis of evaluation policy and assessor reports. The findings show a large focus on quality as goal fulfilment among both students and teachers. Ideas diverge where students focus more on relative quality and consistency, and teachers on transforming the students’ thinking. Policy is also focused upon goal fulfilment though kept relatively vague, inviting stakeholders to influence how quality is defined. Theoretical quality concepts from Harvey and Green (1993) are used and developed further in their practical application, with emphasis on the somewhat contested use of quality as consistency within the sphere of higher education. The findings also suggest a need for more explicit discussions between stakeholders regarding the view of quality within the university internal evaluations. 

  • Public defence: 2019-02-25 13:00 Ekmansalen, Uppsala
    Weissensteiner, Matthias H.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Evolutionary genomics in Corvids: – From single nucleotides to structural variants2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations.

    In this thesis I aim to comprehensively characterize and quantify genetic variation in a natural system, the songbird genus Corvus.

    First, we expand on previous work from a hybrid zone of different populations of Eurasian crows. All black carrion crows and black-and-grey hooded crows meet in a narrow hybrid zone in central Europe, and also in central and Southeast Asia. Comparing population genetic data acquired from these three hybrid zones yielded no single genetic region as a candidate responsible for phenotypic divergence, yet a parallelism in sets of genes and gene networks was evident.

    Second, we capitalize on varying evolutionary timescales to investigate the driver of the heterogeneous genetic differentiation landscape observed in multiple avian species. Genetic diversity, and thus differentiation, seems to be correlated both between populations within single species and between species which diverged 50 million years ago. This pattern is best explained by conserved broad-scale recombination rate variation, which is in turn likely associated with chromosomal features such as centromeres and telomeres.

    Third, we introduce a de-novo assembly of the hooded crow based on long-read sequencing and optical mapping. The use of this technology allowed a glimpse into previously hidden regions of the genome, and uncovered large-scale tandem repeat arrays consisting of a 14-kbp satellite repeat or its 1.2-kpb subunit. Furthermore, these tandem repeat arrays are associated with regions of reduced recombination rate.

    Lastly, we extend the population genetic analysis to structural genomic variation, such as insertions and deletions. A large-scale population re-sequencing data set based on short-read and long-read technologies, spread across the entire genus is the foundation of a fine-scale genome-wide map of structural variation. A differentiation outlier approach between all-black carrion and black-and-grey hooded crows identified a 2.25-kilobase LTR retrotransposon inserted 20-kb upstream of the NDP gene. The element, which is fixed in the hooded crow population, is associated with decreased expression of NDP and may be responsible for differences in plumage color.

    List of papers
    1. Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex
    Open this publication in new window or tab >>Evolution of heterogeneous genome differentiation across multiple contact zones in a crow species complex
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    2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, article id 13195Article in journal (Refereed) Published
    Abstract [en]

    Uncovering the genetic basis of species diversification is a central goal in evolutionary biology. Yet, the link between the accumulation of genomic changes during population divergence and the evolutionary forces promoting reproductive isolation is poorly understood. Here, we analysed 124 genomes of crow populations with various degrees of genome-wide differentiation, with parallelism of a sexually selected plumage phenotype, and ongoing hybridization. Overall, heterogeneity in genetic differentiation along the genome was best explained by linked selection exposed on a shared genome architecture. Superimposed on this common background, we identified genomic regions with signatures of selection specific to independent phenotypic contact zones. Candidate pigmentation genes with evidence for divergent selection were only partly shared, suggesting context-dependent selection on a multigenic trait architecture and parallelism by pathway rather than by repeated single-gene effects. This study provides insight into how various forms of selection shape genome-wide patterns of genomic differentiation as populations diverge.

    National Category
    Evolutionary Biology Genetics
    Identifiers
    urn:nbn:se:uu:diva-308915 (URN)10.1038/ncomms13195 (DOI)000386500600001 ()27796282 (PubMedID)
    Funder
    Knut and Alice Wallenberg FoundationSwedish Research Council, 621-2010-5553EU, European Research Council, ERCStG-336536
    Available from: 2016-12-01 Created: 2016-12-01 Last updated: 2019-01-07Bibliographically approved
    2. Genomewide patterns of variation in genetic diversity are shared among populations, species and higher-order taxa
    Open this publication in new window or tab >>Genomewide patterns of variation in genetic diversity are shared among populations, species and higher-order taxa
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    2017 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 26, no 16, p. 4284-4295Article in journal (Refereed) Published
    Abstract [en]

    Genomewide screens of genetic variation within and between populations can reveal signatures of selection implicated in adaptation and speciation. Genomic regions with low genetic diversity and elevated differentiation reflective of locally reduced effective population sizes (N-e) are candidates for barrier loci contributing to population divergence. Yet, such candidate genomic regions need not arise as a result of selection promoting adaptation or advancing reproductive isolation. Linked selection unrelated to lineage-specific adaptation or population divergence can generate comparable signatures. It is challenging to distinguish between these processes, particularly when diverging populations share ancestral genetic variation. In this study, we took a comparative approach using population assemblages from distant clades assessing genomic parallelism of variation in N-e. Utilizing population-level polymorphism data from 444 resequenced genomes of three avian clades spanning 50 million years of evolution, we tested whether population genetic summary statistics reflecting genomewide variation in N-e would covary among populations within clades, and importantly, also among clades where lineage sorting has been completed. All statistics including population-scaled recombination rate (rho), nucleotide diversity (pi) and measures of genetic differentiation between populations (F-ST, PBS, d(xy)) were significantly correlated across all phylogenetic distances. Moreover, genomic regions with elevated levels of genetic differentiation were associated with inferred pericentromeric and subtelomeric regions. The phylogenetic stability of diversity landscapes and stable association with genomic features support a role of linked selection not necessarily associated with adaptation and speciation in shaping patterns of genomewide heterogeneity in genetic diversity.

    Place, publisher, year, edition, pages
    WILEY, 2017
    Keywords
    background selection, genetic diversity, genetic draft, genetic hitchhiking, linked selection, recombination rate, speciation genetics
    National Category
    Biological Sciences
    Identifiers
    urn:nbn:se:uu:diva-333716 (URN)10.1111/mec.14195 (DOI)000407255100013 ()28570015 (PubMedID)
    Funder
    Swedish Research Council, 621-2010-5553, 2014-6325, 2013-08721EU, European Research Council, ERCStG-336536Knut and Alice Wallenberg FoundationSwedish National Infrastructure for Computing (SNIC)
    Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2019-01-07Bibliographically approved
    3. Combination of short-read, long-read, and optical mapping assemblies reveals large-scale tandem repeat arrays with population genetic implications
    Open this publication in new window or tab >>Combination of short-read, long-read, and optical mapping assemblies reveals large-scale tandem repeat arrays with population genetic implications
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    2017 (English)In: Genome Research, ISSN 1088-9051, E-ISSN 1549-5469, Vol. 27, no 5, p. 697-708Article in journal (Refereed) Published
    Abstract [en]

    Accurate and contiguous genome assembly is key to a comprehensive understanding of the processes shaping genomic diversity and evolution. Yet, it is frequently constrained by constitutive heterochromatin, usually characterized by highly repetitive DNA. As a key feature of genome architecture associated with centromeric and subtelomeric regions, it locally influences meiotic recombination. In this study, we assess the impact of large tandem repeat arrays on the recombination rate landscape in an avian speciation model, the Eurasian crow. We assembled two high-quality genome references using single-molecule real-time sequencing (long-read assembly [LR]) and single-molecule optical maps (optical map assembly [ OM]). A three-way comparison including the published short-read assembly (SR) constructed for the same individual allowed assessing assembly properties and pinpointing misassemblies. By combining information from all three assemblies, we characterized 36 previously unidentified large repetitive regions in the proximity of sequence assembly breakpoints, the majority of which contained complex arrays of a 14-kb satellite repeat or its 1.2-kb subunit. Using whole-genome population resequencing data, we estimated the population-scaled recombination rate (rho) and found it to be significantly reduced in these regions. These findings are consistent with an effect of low recombination in regions adjacent to centromeric or subtelomeric heterochromatin and add to our understanding of the processes generating widespread heterogeneity in genetic diversity and differentiation along the genome. By combining three different technologies, our results highlight the importance of adding a layer of information on genome structure that is inaccessible to each approach independently.

    Place, publisher, year, edition, pages
    COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2017
    National Category
    Biological Sciences
    Identifiers
    urn:nbn:se:uu:diva-323040 (URN)10.1101/gr.215095.116 (DOI)000400392400005 ()28360231 (PubMedID)
    Funder
    Knut and Alice Wallenberg FoundationSwedish National Infrastructure for Computing (SNIC)Swedish Research Council, 621-2010-5553EU, European Research Council, ERCStG-336536
    Available from: 2017-06-01 Created: 2017-06-01 Last updated: 2019-01-07Bibliographically approved
    4. Fine-scale analysis of Structural Genomic Variation in Natural Populations
    Open this publication in new window or tab >>Fine-scale analysis of Structural Genomic Variation in Natural Populations
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    (English)Manuscript (preprint) (Other (popular science, discussion, etc.))
    National Category
    Evolutionary Biology
    Identifiers
    urn:nbn:se:uu:diva-369880 (URN)
    Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07
  • Lindqvist, Sofie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Understanding Participation: A Quantitative Study of the Relationship Between Political Trust and Different Forms of Political Participation in the United Kingdom2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Trust in elected representatives and the political institutions within which they operate is often emphasised as a prerequisite for citizens’ political participation. While research has indeed shown a positive correlation between political trust and participation, it has contrarily also been suggested that low levels of trust might function as a driving force for participation. With empirical evidence remaining equivocal, the relationship between political trust and political participation is yet to be fully comprehended. By focusing on one case, using the latest available European Social Survey data, and examining trust and participation rates over time, this study aims at yielding further insight into this matter. The results from the study show that the relationship between political trust and political participation is indeed ambiguous. As anticipated, political trust correlates positively with voting and negatively with so-called non-institutionalised political participation. However, political trust also correlates negatively with so-called institutionalised participation, contrary to expectation and perhaps quite notable. The results additionally suggest that the categorisation of different participation types might benefit from a revision. Moreover, also perchance remarkable, the results show that levels of political trust and political participation have been stable over time. No decline can be noted for either trust or participation, despitere occurring claims of such developments. Based on the results of this study, low levels of political trust have neither become more widespread nor had a negative impact on political participation.

  • Eklöf, Oskar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Voting behaviour in the 2014 European Parliament election2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The European Parliament election is one of the most extensive elections in the world and affects more than 500 million people within the European Union. Prior research have mainly been using two different frameworks to explain voting behaviour in the European Parliament elections, namely the second-order election theory and the Europe-matters framework. The second-order theory states that national issues play a major role in the voting behaviour and the Europe-matters frameworks basically imply that European issues play a major role in the citizens’ voting behaviour. Prior research has relied too much on aggregate data, has operationalised the frameworks wrongly and has not given equal weight to the frameworks. In this study, I tried to come to terms with these problems and the research question was to test which of the frameworks that best explains the voting behaviour in the European Parliament election of 2014. The results are mixed and no framework seem to explain the voting behaviour better than the other. Nevertheless, other interesting results are possible to find and two of these results are that people tend to cast protest votes against their government if they disapprove it and that EU disapproval affects abstaining from voting more than government disapproval does, in the European Parliament election of 2014.

  • Berry, Tom
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Examining the populist form of representation: The case of Podemos2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis examines the Spanish left-wing party Podemos and their populist way of expressing politics. There is a vast empirical literature which tries to capture the different elements of populist parties. This thesis seeks to go beyond this, through examining populism as a form of representation. Since scholars have claimed that mainstream parties are facing a crisis of representation, it is of great relevance to understand which sort of representation that populist parties offer in turn. Podemos has in previous research been considered as a new form of left-wing party, primarily because they actively have stepped away from using a traditional left-wing terminology. Instead, Podemos has been recognized for their populist way of expressing politics, through dividing the Spanish society into “the people” and “the elite”. However, this division of the Spanish society has not been interpreted and examined in terms of representation. To examine what I have labeled the populist form of representation, the thesis investigates the political style of Podemos secretary general, Pablo Iglesias, and his way of creating the subject which populist parties claims to represent – “the people”.

     

    The result of the study shows that Podemos has a populist form of representation. The secretary general of Podemos, Pablo Iglesias, adopts a populist style and he constructs a populist “people” through claiming to represent several groups and demands in society. Further, the thesis has shown that Iglesias style as well is dependent on several contextual elements, such as technocratic, cultural and left-wing features of performance. Moreover, even though the construction of “the people” is consisting of the claim to represent several demands, they are all tied to a general defense of the Spanish welfare state. The thesis has further shown that Iglesias creation of “the people” consists of characterizing it as the ordinary people, the colorful people, the historical people and the governing people.

  • Matejcic, Marco
    et al.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Saunders, Edward J.
    Inst Canc Res, London SW7 3RP, England..
    Dadaev, Tokhir
    Inst Canc Res, London SW7 3RP, England..
    Brook, Mark N.
    Inst Canc Res, London SW7 3RP, England..
    Wang, Kan
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Sheng, Xin
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Al Olama, Ali Amin
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England..
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA..
    Ingles, Sue A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Govindasami, Koveela
    Inst Canc Res, London SW7 3RP, England..
    Benlloch, Sara
    Inst Canc Res, London SW7 3RP, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England..
    Berndt, Sonja, I
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Muir, Kenneth
    Univ Manchester, Inst Populat Hlth, Manchester M13 9PL, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England..
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA..
    Gapstur, Susan M.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA..
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA..
    Batra, Jyotsna
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia..
    Clements, Judith
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia..
    Gronberg, Henrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
    Pashayan, Nora
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England.;UCL, Dept Appl Hlth Res, London WC1E 7HB, England..
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Dept Med Biochem & Genet, FI-20014 Turku, Finland.;Turku Univ Hosp, Dept Med Genet, Tyks Microbiol & Genet, Turku 20521, Finland.;Univ Tampere, BioMediTech, Tampere 33520, Finland..
    Wolk, Alicja
    Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, SE-17177 Stockholm, Sweden..
    West, Catharine
    Univ Manchester, Christie Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr,Div Canc Sci, Manchester NIHR Biomed Res Ctr,Radiotherapy Relat, Manchester M13 9PL, Lancs, England..
    Mucci, Lorelei
    Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA..
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA..
    Cancel-Tassin, Geraldine
    UPMC Univ Paris 06, Tenon Hosp, GRC ONCOTYPE URO 5, F-75020 Paris, France.;Tenon Hosp, CeRePP, F-75020 Paris, France..
    Sorensen, Karina D.
    Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus N, Denmark..
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway..
    Grindedal, Eli M.
    Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway..
    Strom, Sara S.
    Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA..
    Neal, David E.
    Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 0QQ, England.;Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England..
    Hamdy, Freddie C.
    Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England..
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Canynge Hall,39 Whatley Rd, Bristol BS8 2PS, Avon, England..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol, Oxford OX3 7LF, England..
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON M5G 2M9, Canada..
    Rosenstein, Barry
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA..
    Lu, Yong-Jie
    Queen Mary Univ London, Ctr Mol Oncol, John Vane Sci Ctr, Barts Canc Inst, London EC1M 6BQ, England..
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia..
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA..
    Vega, Ana
    Fdn Publ Galega Med Xenom SERGAS, CIBERER, IDIS, Grp Med Xenom, Santiago De Compostela 15706, Spain..
    Bensen, Jeanette T.
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Columbia, SC 29208 USA..
    Kogevinas, Manolis
    Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Hosp del Mar, IMIM, Res Inst, Barcelona 08003, Spain.;UPF, Barcelona 08002, Spain..
    Penney, Kathryn L.
    Harvard Med Sch, Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, MA 02184 USA..
    Park, Jong Y.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA..
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA..
    Cybulski, Cezary
    Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland..
    Nordestgaard, Borge G.
    Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2200 Copenhagen, Denmark..
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany..
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, D-89075 Ulm, Germany..
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA..
    Teixeira, Manuel R.
    Portuguese Oncol Inst Porto, Dept Genet, P-4200072 Porto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, P-4050313 Porto, Portugal..
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA 91010 USA..
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, B-9000 Ghent, Belgium..
    Razack, Azad
    Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia..
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Dept Urol, Seattle, WA 98195 USA..
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, D-20246 Hamburg, Germany..
    Kaneva, Radka
    Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, Sofia 1431, Bulgaria..
    Usmani, Nawaid
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada.;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, Edmonton, AB T6G 1Z2, Canada..
    Claessens, Frank
    Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, BE-3000 Leuven, Belgium..
    Townsend, Paul A.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Hlth Innovat Manchester, Manchester Canc Res Ctr,NIHR Manchester Biomed Re, Manchester M13 9WL, Lancs, England..
    Dominguez, Manuela G.
    Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med,Serv Galego, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA..
    Roobol, Monique J.
    Erasmus Univ, Dept Urol, Med Ctr, NL-3015 CE Rotterdam, Netherlands..
    Menegaux, Florence
    Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, F-94807 Villejuif, France..
    Khaw, Kay-Tee
    Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England..
    Cannon-Albright, Lisa A.
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA..
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England..
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA..
    Schaid, Daniel J.
    Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA..
    Wiklund, Fredrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Easton, Douglas F.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England..
    Eeles, Rosalind A.
    Inst Canc Res, London SW7 3RP, England.;Royal Marsden NHS Fdn Trust, London SW3 6JJ, England..
    Kote-Jarai, Zsofia
    Inst Canc Res, London SW7 3RP, England..
    Conti, David, V
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Germline variation at 8q24 and prostate cancer risk in men of European ancestry2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 4616Article in journal (Refereed)
    Abstract [en]

    Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 x 10(-15)), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95% CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for similar to 25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

  • Wollter, August
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sensitivity Study of Higgs Boson Pair Production with WWττ Final States at 13 TeV in the ATLAS Experiment2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This feasibility study concerns the implementation and analysis of a Higgs pair decaying to two W bosons, with hadronic final states, and to two τ-leptons, one with a leptonic and one with a hadronic final state, hh→ WhadWhad τlepτhad, in the ATLAS detector at the CERN Large Hadron Collider, by adapting the ``CxAOD framework'' software analysis code of the hh→ bbττ analysis. The purpose is to compare the sensitivity of this final state with other di-Higgs analyses in the ATLAS collaboration.

    Monte Carlo samples are used for the background and signal simulation. A cut based selection is then performed based on several kinematic variables. Finally, a statistical analysis is performed on the MMC mass distribution of the ττ system.

    The cross section can be limited at the 95 %  confidence level to σexpected < 89.8 fb, compared to the theoretical σSM = 0.19 fb.

  • Palmer, Django
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Estimating the LES demand system using Finnish household budget survey data.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Zeiger, Paul Michel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Influence of non-dipole trnasitions on the extraction of EMCD2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    ELNES-spectra of the L3 and L2-edge of bcc-iron are simulated using a Bloch wave method for the calculation of the DDSCS within a 1st-order Born approximation of the inelastic electron scattering process in order to study the influence of non-dipole terms on the EMCD-signal. The necessary electronic structure information is obtained from a DFT-calculation using WIEN2k.Two different different ways of extracting the EMCD-signal are considered: the pEMCD-signal, which is extracted from the pure imaginary part of the MDFF, and the eEMCD-signal, extracted via an EMCD difference method.A non-negligible contribution of the 13 cross term to the eEMCD-signal is found. Furthermore it is shown that the double difference method and the single left-right difference method cancel out the contributions of the 01-term to the eEMCD-signal. The pEMCD-signal is found to be influenced by non-dipole terms only for large scattering angles. Conclusive quantitative results on the influence of non-dipole contributions to the eEMCD-signal remain to be found, however, since it is uncovered that the eEMCD-signal is strongly disturbed by the choice of the post-edge normalization range due to the inaccurate description of the post-edge region in the present simulation. Furthermore a not anticipated "apparent anisotropy" of the real part of the MDFF is found, whose cause is presently unknown.As a byproduct of these investigations deeper insight is gained on a reason, why the double difference method is superior to the other extraction methods. It practically eliminates the effect of non-dipole terms 01 and 12.Lastly two effects are encountered that might pave the way to a deeper understanding of why the L2-edge is experimentally often observed to be weakened or suppressed relative to the L3-edge in comparison with simulations.

  • Ungar, Leo
    et al.
    Univ Calif Irvine, Dept Cardiol, Med Ctr, Orange, CA 92668 USA.
    Clare, Robert M.
    Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA.
    Rodriguez, Fatima
    Stanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA USA.
    Kolls, Bradley J.
    Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA.
    Armstrong, Paul W.
    Univ Alberta, Div Cardiol, Edmonton, AB, Canada.
    Aylward, Philip
    Flinders Univ S Australia, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia;Med Ctr, Adelaide, SA, Australia.
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Moliterno, David J.
    Univ Kentucky, Gill Heart Inst, Div Cardiovasc Med, Lexington, KY USA.
    Strony, John
    Johnson & Johnson, New Brunswick, NJ USA.
    Van de Werf, Frans
    Univ Hosp Leuven, Dept Cardiovasc Sci, Leuven, Belgium.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    White, Harvey D.
    Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.
    Tricoci, Pierluigi
    Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA.
    Harrington, Robert A.
    Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
    Mahaffey, Kenneth W.
    Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
    Melloni, Chiara
    Duke Clin Res Inst, Dept Med, Durham, NC 27710 USA.
    Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial2018In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 7, no 24, article id e009609Article in journal (Refereed)
    Abstract [en]

    Background

    Vorapaxar, a protease‐activated receptor‐1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage.

    Methods and Results

    TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) was a trial of vorapaxar versus placebo among patients with acute coronary syndrome. Strokes were adjudicated by a central events committee. Of 12 944 patients, 199 (1.5%) had ≥1 stroke during the study period (median follow‐up, 477 days). Four patients had a single stroke of unknown type; 195 patients had ≥1 stroke classified as hemorrhagic or nonhemorrhagic (165 nonhemorrhagic, 28 hemorrhagic, and 2 both). Strokes occurred in 96 of 6473 patients (1.5%) assigned vorapaxar and 103 of 6471 patients (1.6%) assigned placebo. Kaplan‐Meier incidence of stroke for vorapaxar versus placebo was higher for hemorrhagic stroke (0.45% versus 0.14% [hazard ratio, 2.74; 95% confidence interval, 1.22–6.15]), lower but not significantly different for nonhemorrhagic stroke (1.53% versus 1.98% at 2 years [hazard ratio, 0.79; 95% confidence interval, 0.58–1.07]), and similar for stroke overall (1.93% versus 2.13% at 2 years [hazard ratio, 0.94; 95% confidence interval, 0.71–1.24]).

    Conclusions

    Stroke occurred in <2% of patients. Vorapaxar‐assigned patients had increased hemorrhagic stroke but a nonsignificant trend toward lower nonhemorrhagic stroke. Overall stroke frequency was similar with vorapaxar versus placebo.

  • Pérez Andrade, Gabriela
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Production of the Σ0-bar hyperon in the PANDA experiment at FAIR2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The PANDA experiment is one of the main pillars of the Facility for Antiproton and Ion Research (FAIR), currently under construction in Darmstadt, Germany. PANDA will be a fixed target experiment designed for the study of non-perturbative phenomena of the strong interaction. Strange hyperon production is governed by m(s)  ~ 100 MeV, which corresponds to the confinement domain. Thus, hyperons are suitable probes in this energy region. This work is a simulation study focused on the feasibility of studying the production of Σ0-bar and Λ hyperons in the pbar p -> Σ0-bar Λ reaction with the PANDA detector. A 10^4 events sample simulated at p(beam) = 1.771 GeV/c is used to perform a single-tag (inclusive) and a double-tag (exclusive) event selection. From the former, it is concluded that the single-tag method does not provide with the clean signal required for spin observables extraction. In contrast, exclusive event selection provides with a signal reasonably clean from combinatorial background and completely clean from generic hadronic background events. A signal (Σ0-bar Λ) reconstruction efficiency of ε = 5.3 ± 0.2 % is obtained for exclusive event selection. The corresponding signal to background ratio is S/B(Total) ~ 6 and the significance value is ~ 21.

    In addition, an exclusive event selection is performed on a 10^4 events sample simulated at p_(beam) = 6 GeV/c. Almost all the generic hadronic background events are removed by the applied selection criteria. At this beam momentum, the obtained signal efficiency is ε = 6.1 ± 0.3%, the signal to total background ratio is S/B(Total) ~ 4 and the significance is ~22. Both efficiencies are smaller compared to a previous simulation study on this channel, but are large enough to enable a study of the exclusive production of the pbar p -> Σ0-bar Λ reaction at PANDA. The difference between the results of this thesis work and the previous work is attributed to the more realistic implementation of the signal production mechanism, as well as the detector and reconstruction algorithms.

  • Panizo, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Type IIB compactifications and string dualities2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the present thesis, we offer an introduction to type IIB string compactifications on $\mathbb{T}^{d}/\Gamma$ toroidal orbifolds. We first describe the technical method to construct these spaces and reduce the string background on it. We will have (non)-geometrical fluxes arising from these spaces which decorate with discrete deformations our four $\mathcal{N}=1$ dimensional supergravity theory. Solving its equations of motion, we find several families of supersymmetric AdS vacua with fixed moduli, which can be related through a set of  $SL(2,\mathbb{Z})$ symmetries.

  • Rokhas, Maria Khihon
    et al.
    KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Chemistry, Div. of Applied Physical Chemistry, Analytical Chemistry, Stockholm, Sweden.
    Rönn, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Wiklund, Christer
    Stockholm University, Dept. of Zoology, Ecology, Stockholm, Sweden.
    Emmer, Åsa
    KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Chemistry, Div. of Applied Physical Chemistry, Analytical Chemistry, Stockholm, Sweden.
    Analysis of butterfly reproductive proteins using capillary electrophoresis and mass spectrometry2019In: Analytical Biochemistry, ISSN 0003-2697, E-ISSN 1096-0309, ISSN 0003-2697, Vol. 566, p. 23-26Article in journal (Refereed)
    Abstract [en]

    A method for analysis of proteins from spermatophores transferred from male to female Pieris napi butterflies during mating has been developed. The proteins were solubilized from the dissected spermatophores using different solubilization agents (water, methanol, acetonitrile and hexafluoroisopropanol). Capillary electrophoresis (CE) analysis was performed using an acidic background electrolyte containing a fluorosurfactant to avoid protein-wall adsorption, and to increase separation performance. The samples were also analyzed with matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), in a lower m/z range (1000-6000) and a higher m/z range (6000-12000). Solubilization with different solvents and the use of alternative matrices gave partly complementary profiles.

  • Åström, Hedvig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Kristnas tal om Gud i ljuset av feministisk kritik2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this essay is to examine how Christians can and should speak about God if they take feminist criticism seriously. This purpose concerns two problems: the first starts with the proposition that God is essentially different from humans and things and at the fact that the language that we use to describe and speak about God is a human language. God is infinite, incorporeal, and timeless, while the human language normally is used to apply to finite, corporeal, and temporal things. How – if ever – can this language apply to God? To examine this problem further, I present four different theories of religious language.

    The second problem is actualized by feminists who criticize the standard within the Christian tradition to characterize God in predominantly masculine terms. Feminists have criticised religious language for being oppressive in several ways, and particularly to establish and maintain hierarchical structures in which women are subordinated men. In this essay I present and discuss feminist criticism of religious language and then distinguish four different strategies for feminists. I further examine three of these strategies, represented by Sallie McFague, Gail Ramshaw and Janet Soskice, dealing with the problem of religious language within the Christian tradition. In all three of these feminist strategies metaphors are found to be of great importance.

    Finally, I promote Soskice metaphor theory combined with an apophatic theory of language. Soskice stresses the importance of anthropomorphous metaphors and offer the possibility of using both male and female images when speaking about God. This strategy positively handles the proposition of God as essentially different but makes it possible for believers to refer to God (through metaphors). This is also the preferable strategy in line with feminist criticism.

  • Ekholm, Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Varberg – en stadsbild i förändring: En studie om genusmönster i staden2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsen undersöker vilka förändringar som har skett i stadsplaneringen i en utvald svensk stad under 1970- och 1980-talen till dagens datum år 2017 ur ett genusperspektiv. Staden som är vald är Varberg, Halland. Studien har gjorts genom att undersöka kartor och intervjupersoner som arbetat med stadsplanering i Varberg under 1970- och 1980-talen, samt personer som arbetar med det idag. Studien är en kvalitativ studie med inriktning på ostrukturerade intervjuer. Följande var mina frågeställningar:• På vilket sätt har stadsbilden förändrats genom årtiondena i Varberg?• Hur har de manliga och kvinnliga rörelsemönster sett ut i Varberg?• Vad är de största skillnaderna på dagens översiktsplanering och den från 1978?Studien visar att rörelsemönster är ständigt skiftande och att Varberg som stad har blivit större än vad som estimerades på 1970-talet. Under 1970-talet var Varberg en industristad, idag kan den snarare benämnas som en turiststad, där turismen har ett starkt fäste och är en stor del av näringslivet. Fler kvinnor har välkomnats in i planeringsrummet och staden har ett annat fokus på utveckling idag. Framförallt för mål mer konkretiserad, skola och utbildning har större plats i översiktsplanering. Det manliga och kvinnliga rörelsemönstret har skilt sig åt, då industrin funnits i nord och skolor, vård och affärer i söder. Staden har utvecklats för att bibehålla en stadskärna och inte utlokalisera detaljhandel och därmed öppna upp för att oavsett vem du är ska ha nära till centrum.

  • Elfström, Per
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy.
    Idé, objekt eller ingenting?: En studie om fiktiva karaktärer2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Detta är en uppsats där jag för en diskussion om ett par aspekter som rör den filosofiska debatten om fiktiva karaktärer. I den första delen av analysen diskuterar jag ett antal olika ontologiska teser om fiktiva karaktärer såsom, till exempel, non-actualism och abstractism. I den andra delen av analysen så diskuteras fiktiva karaktärer utifrån hur deras namn används i olika sorters diskurs (fiktiv diskurs och kritisk diskurs framförallt).           

  • Lindqvist, Cecilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Personalbrist eller brist på kompetensförsörjning?: En studie kring HR-praktikers arbete med att utveckla och behålla kompetens inom organisationer2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I dagens arbetsliv poängteras hur personalen är organisationernas viktigaste resurser, trots det är personalbrist ett vanligt problem inom flera organisationer. Denna studie syftar till att skapa kunskap om HR-praktikers arbete med att utveckla och behålla befintlig kompetens inom organisationen, med en personalbrist i grunden. Specifikt undersöks hur HR-praktiker på ett svenskt sjukhus arbetar med att behålla och utveckla sina sjuksköterskor. Undersökningen lutar sig mot frågeställningarna: vad för typ av problembakgrund föranleder HR-praktikers arbete med behållning och utveckling av sjuksköterskor i organisationen? vilka förutsättningar och strategier utvecklas för att skapa gynnsamma förutsättningar för HR-praktikers arbete med behållning och utveckling av sjuksköterskor? samt vad upplever HR-praktiker att de har för möjligheter och begränsningar i sitt arbete? Med stöd i tankar kring bland annat organisationspedagogik och Human Resource Development undersöker studien hur ett utvecklat arbete med kompetensförsörjning kan skapa möjligheter för HR-praktiker att arbeta med behållning och utveckling av befintlig personal. Med hjälp av dokumentanalys av skrifter från Sveriges Kommuner och Landsting beskrivs den problembakgrund som finns i dagens organisationer och därifrån möjliga lösningar. Personalbrist förväntas öka med åren på grund av demografiska förändringar och kompetensförsörjning kommer tillskrivas än större vikt än idag. Speciellt tre problemlösningar hamnar i fokus: att förändra de rådande arbetssätten, att utnyttja digitaliseringen samt att satsa starkare på kompetensutveckling och bildning. Med hjälp av vidare dokumentanalys går dessa tre problemlösningar att finna i de lokala handlingsplaner och arbetsmaterial som studiens sjukhus arbetar utifrån. På landstingsnivå har material skapats för att mer effektivt arbeta med behållning och utveckling, till exempel kompetensstege för sjuksköterskor och utvecklade roller på sjukhusens avdelningar som ska se till att rätt kompetens finns på rätt plats. Utifrån studiens intervjuer med sjukhusets HR-praktiker blir det än tydligare att sjukhuset anammat de problemlösningar och riktlinjer Sveriges Kommuner och Landsting utvecklat, men att det även finns begränsningar inom arbetet som kan utvecklas. Studien ser att ett utvecklat och genomtänkt arbete med kompetensförsörjning finns levande och att studiens sjukhus både medvetet och omedvetet följer givna lösningsförslag samt forskningens tankar kring ämnet. Bland de medvetna arbetssätten finns specialist-utbildningsprogram för sjuksköterskor och bland de omedvetna kan olika motivationsformer utläsas, utan att organisationen har en tydlig motivationsmodell aktiv.

  • Joelsson, Ingrid
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kajgård, Tyra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Anställdas meningsskapande: En studie av doktoranders meningsskapande till introduktionsprocessen på Uppsala universitet2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In light of a changeable labor market characterized by structural transformation and technical development, organizations today need to work actively on maintaining their labor force. Studies show that employees who consider their work meaningful and are happy with their introduction tend to stay employed longer at the organization, then employees that are dissatisfied. The purpose of this study is to contribute with knowledge of employees’ sensemaking. This purpose has been achieved by study of how PhD students at Uppsala university make sense of their introduction process. In order to capture the individuals’ sensemaking of the introduction process, semi-structured interviews were conducted with six PhD students, all of whom have participated in the same introduction process. To gain further insight into how sensemaking is expressed, in regard to introduction processes, we have used Karl Weick's (1995) theory of sensemaking in organizations. Through coding and thematization of interview transcripts the research questions How do PhD students describe their experience of the introduction process? and How do PhD students experience that they have been affected by the introduction process? are answered. The results demonstrate that employees experience the introduction as a continuous and sequencing process and that their background and expectations affect their experience. Individuals make sense of the introduction process through communication as well as by opposing and adapting to the messages conveyed from the organization. The results also show that sensemaking interacts with identity construction and action.

  • Eklund, Melissa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Gymnasieskolornas arbete kring ekomålet: 100 procent ekologiska inköp år 20232018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker ett av Uppsala kommuns etappmål inom klimat- och miljöarbete och hur den kommunala målstyrningen påverkar gymnasieskola och anställdas interna arbete. För att analysera det organisatoriska arbetet och implementeringar av målet används teorier kring neoliberalism och new public management (NPM). Till studien har textanalys och semistrukturerade intervjuer genomförts. Resultatet indikerar att målträngsel är ett faktum för skolans verksamheter vilket även påverkar implementeringen och hanteringen av ekomålet. Hur det påverkar de anställda beror mycket på individens kunskap och ansvarsområde. Skolans storlek har stor betydelse på tillämpningen av målet och arbetsbelastningen på ansvarig personal. Vidare visar studien på att den kommunala styrningen både medför en hårdare intern styrning inom verksamheterna samtidigt som utrymmet för ledarskap kan tyckas öka. 

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for heavy charged long-lived particles in proton-proton collisions at root s=13 TeV using an ionisation measurement with the ATLAS detector2019In: Physics Letters B, ISSN 0370-2693, E-ISSN 1873-2445, Vol. 788, p. 96-116Article in journal (Refereed)
    Abstract [en]

    This Letter presents a search for heavy charged long-lived particles produced in proton-proton collisions at root s= 13 TeV at the LHC using a data sample corresponding to an integrated luminosity of 36.1 fb(-1) collected by the ATLAS experiment in 2015 and 2016. These particles are expected to travel with a velocity significantly below the speed of light, and therefore have a specific ionisation higher than any high-momentum Standard Model particle of unit charge. The pixel subsystem of the ATLAS detector is used in this search to measure the ionisation energy loss of all reconstructed charged particles which traverse the pixel detector. Results are interpreted assuming the pair production of R-hadrons as composite colourless states of a long-lived gluino and Standard Model partons. No significant deviation from Standard Model background expectations is observed, and lifetime-dependent upper limits on R-hadron production cross-sections and gluino masses are set, assuming the gluino always decays to two quarks and a 100 GeV stable neutralino. R-hadrons with lifetimes above 1.0 ns are excluded at the 95% confidence level, with lower limits on the gluino mass ranging between 1290 GeV and 2060 GeV. In the case of stable R-hadrons, the lower limit on the gluino mass at the 95% confidence level is 1890 GeV.

  • Volkov, Ivan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Johansson, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.
    Single-Molecule Tracking Approaches to Protein Synthesis Kinetics in Living Cells2019In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 58, no 1, p. 7-14Article in journal (Refereed)
    Abstract [en]

    Decades of traditional biochemistry, structural approaches, and, more recently, single-molecule-based in vitro techniques have provided us with an astonishingly detailed understanding of the molecular mechanism of ribosome-catalyzed protein synthesis. However, in order to understand these details in the context of cell physiology and population biology, new techniques to probe the dynamics of molecular processes inside the cell are needed. Recent years' development in super-resolved fluorescence microscopy has revolutionized imaging of intracellular processes, and we now have the possibility to directly peek into the microcosm of biomolecules in their native environment. In this Perspective, we discuss how these methods are currently being applied and further developed to study the kinetics of protein synthesis directly inside living cells.

  • Trimmer, Charlotte
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Målqvist, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Child Health and Nutrition.
    Clinical communication and caregivers' satisfaction with child healthcare in Nepal: results from Nepal Health Facility Survey 20152019In: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 19, article id 17Article in journal (Refereed)
    Abstract [en]

    Background: Patient satisfaction is an important measure of quality of care and a determinant of health service utilisation and the choice of health facility. Measuring patients' experiences is important for understanding and improving the quality of care at health facilities. The aim of this study was to assess levels and identify associated factors of caregivers' satisfaction and provider-caregiver communication within child healthcare in Nepal.

    Methods: Secondary analysis of Sick Child Exit Interviews (n=2092) sourced from 2015 Nepal Health Facility Survey data. Satisfaction was measured through caregivers' satisfaction with services received and their willingness to recommend the health facility visited. Communication indicators were chosen based on the 2014 WHO IMCI guidelines and aggregate communication scores were calculated based on the number of indicators acknowledged during assessments. Logistic regression was used for analysis.

    Results: Although most respondents (82.1%) reportedly were satisfied with the care provided, only 35.9% experienced good communication with their providers. Caregivers who had ever attended school were more likely to be satisfied with services (1.44, CI 95% 1.04-1.99). Type of provider, sex of child or who the caregiver was had no association with caregivers' satisfaction. Having been given a diagnosis doubled the chances of satisfaction (AOR 2.04, 95% CI 1.38-3.00), as did discussion of the child's growth (OR 1.71, 95% CI 1.06-2.76) and having discussed any of the included topics (AOR 1.98, CI 95% 1.14-3.45).

    Conclusions: Interventions to improve healthcare staff's communication skills are needed in Nepal to further enhance satisfaction with services and increase quality of care. However, this is an area that need further investigation given the high levels of satisfaction displayed despite poor communication. Other factors in the health care exchange between provider and clients are influencing the level of satisfaction and need to be identified and promoted further. High-quality care is no longer a goal for the future or only for high income settings; it is essential for reaching global health goals.

  • Jonsson, Johanna
    et al.
    Karolinska Inst, Unit Occupat Med, Inst Environm Med, Stockholm, Sweden.
    Stein, Mart
    Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, Bilthoven, Netherlands.
    Johansson, Gun
    Karolinska Inst, Unit Occupat Med, Inst Environm Med, Stockholm, Sweden.
    Bodin, Theo
    Karolinska Inst, Unit Occupat Med, Inst Environm Med, Stockholm, Sweden.
    Strömdahl, Susanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infection medicine. Karolinska Inst, Dept Publ Hlth, Stockholm, Sweden.
    A performance assessment of web-based respondent driven sampling among workers with precarious employment in Sweden2019In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 1, article id e0210183Article in journal (Refereed)
    Abstract [en]

    Objectives: Precarious employment (PE) is a social determinant of poor health of workers. However, this population usually lack a sampling frame, making it challenging to identify the characteristics of this group. Web-based respondent driven sampling (webRDS) recruits individuals online through the social network and can provide population estimates. This study aims to assess the performance of webRDS in a population of workers with PE.

    Method: WebRDS was used for recruitment and data collection in the PRecarious EMployment In Stockholm (PREMIS) study. Cross-sectional questionnaire data was collected between November 2016 and May 2017. Eligible participants were living and/or working in Stockholm County, 18-65 years old, had a personal identification number and were currently employed. WebRDS performance was assessed by the total sample size, length of recruitment chains, sample composition, sample proportions and estimated RDSII population proportions with confidence intervals.

    Results: The webRDS process resulted in a sample of 358 recruits and a total sample of 415 participants, recruited over 1-15 waves. Of the participating seeds and recruits, 60% and 48%, respectively, successfully recruited at least one peer. The sample composition stabilized for all variables assessed. The sample proportions and RDSII estimates differed by 1-8% and the confidence intervals included the sample proportions for all variables except one.

    Conclusions: WebRDS successfully recruited a sufficient sample of workers with precarious employment from which population estimates could be made. Future studies should consider implementing webRDS on a national level in order to further study this population.

  • Reutermo, Elin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Axelsson, Mathilda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    “Man startar väl inte ett kaffeföretag för att rädda miljön”: En studie om Generation Y:s attityder och åsikter på kaffeproducenters CSR-arbete och CSR-kommunikation2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The coffee industry affects both people and the environment in a negative way, which is an aspect coffee producers are forced to relate to. Today, more and more organizations are involved in CSR and communication about CSR. Therefore, the aim of this study is to examine young consumers of Generation Y, their attitudes and opinions towards coffee producers' CSR work and its communication on CSR. The study has two research questions “what does Arvid Nordquist communicates about its CSR work through their official website?” and “what kind of attitudes and opinions does a group of young consumers have on coffee producers' CSR work and communication on CSR?” For this study two theories have been used, the CSR theory Triple Bottom Line as a theoretical starting point and Deegan Unerman’s theory on the social contract, based on Freeman’s stakeholder theory, as a theoretical framework. This qualitative study used two methods of data collection. First, a document analysis of Arvid Nordquists offical website. Secondly, a focus group interview with young consumer of Generation Y. The conclusion that can be drawn from our research is that consumers from Generation Y are positive to CSR as a phenomenon, but that communication of CSR is followed by scepticism in combination with ignorance. This paper sheds light on a issue that in previous research has used quantitative methods, while this study uses qualitative methods. The importance of this paper is its contribution to how organizations can improve their communication of CSR to young consumers.

  • Sundström Poromaa, Inger
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Bäckström, Torbjörn
    Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden.
    Bixo, Marie
    Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden.
    Jensen, Peter
    Rigshosp, Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark;Rigshosp, Copenhagen Univ Hosp, Ctr Integrated Mol Brain Imaging, Copenhagen, Denmark.
    Frokjaer, Vibe G.
    Rigshosp, Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark;Rigshosp, Copenhagen Univ Hosp, Ctr Integrated Mol Brain Imaging, Copenhagen, Denmark;Rigshosp, Copenhagen Univ Hosp, Mental Hlth Serv Copenhagen, Copenhagen, Denmark.
    Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age2019In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 9, article id 2767Article in journal (Refereed)
    Abstract [en]

    Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well-being, the molecular and psychological specifics of their relationship are to date poorly understood, especially in women of fertile age who experience regular fluctuations of progesterone across the menstrual cycle. Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer [C-11]DASB. To evaluate sex-specific allopregnanolone-SERT interactions, the present study investigated the relationship between cerebral SERT availability, serum allopregnanolone levels and psychological well-being in women of fertile age. Brain imaging data, self-reported symptoms of mental distress and emotion regulation, and biobank material from ninety healthy women were available from the Center for Integrated Molecular Brain Imaging (CIMBI) database. Age, BMI, and daylight minutes were included as covariates in the analyses and SERT genotype (5-HTTLPR) was considered a potential confounder. Lower serum allopregnanolone levels were associated with higher SERT binding in the prefrontal cortex. Moreover, allopregnanolone levels were negatively associated with measures of alertness, although this finding was not mediated by prefrontal cortex SERT binding. These findings suggest a link between the typical psychological well-being experienced in the follicular phase when allopregnanolone levels are low and higher SERT in the prefrontal cortex, a region for higher cognitive functions and top-down regulation of emotions.

  • Gunnarsson, Jakob
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Wenestam, Arvid
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    En simuleringsstudie på sannolikhet för typ I-fel och styrka hos olika normalitetstest på avrundade data2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    When data is collected sample size and precision in measurements are often limited. In what sense this impacts the size, unadjusted and adjusted power of different normality tests is a relatively unexplored field. Therefore this paper is dedicated to perform a simulation study where these three properties of the normality tests Anderson-Darling, Jarque-Bera and Shapiro-Wilk are examined. The study is based on different combinations of sample sizes and roundings where repeated samples are drawn from both normally and asymmetrically distributed populations. The results from the study indicate that coarser roundings results in increased size and unadjusted power of Anderson-Darling and Shapiro-Wilk, while Jarque-Bera is seemingly unaffected by roundnings. The three tests have in common that a larger sample size leads to an increase in the size, unadjusted and adjusted power of the tests and that roundings have no substantial impact on adjusted power.

  • Åhman, Annika
    et al.
    Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90187 Umea, Sweden.
    Edvardsson, Kristina
    Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90187 Umea, Sweden;La Trobe Univ, Judith Lumley Ctr, Melbourne, Vic, Australia.
    Fagerli, Tove Anita
    Trondheim Reg & Univ Hosp, Natl Ctr Fetal Med, St Olavs Hosp, Trondheim, Norway.
    Darj, Elisabeth
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH). St Olavs Hosp, Dept Obstet & Gynecol, Trondheim, Norway;Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway.
    Holmlund, Sophia
    Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90187 Umea, Sweden.
    Small, Rhonda
    La Trobe Univ, Judith Lumley Ctr, Melbourne, Vic, Australia;Karolinska Inst, Reprod Hlth Womens & Childrens Hlth, Stockholm, Sweden.
    Mogren, Ingrid
    Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90187 Umea, Sweden;La Trobe Univ, Judith Lumley Ctr, Melbourne, Vic, Australia.
    A much valued tool that also brings ethical dilemmas - a qualitative study of Norwegian midwives' experiences and views on the role of obstetric ultrasound2019In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 19, article id 33Article in journal (Refereed)
    Abstract [en]

    Background: Midwives are the main providers of routine antenatal care services including the routine ultrasound examination in Norway. The ultrasound examination can be perceived by expectant parents not only as a medical examination but also as a social event facilitating attachment to their fetus. This study explores Norwegian midwives' experiences and views on the role of ultrasound in clinical management of pregnancy.

    Methods: A qualitative study design was applied. Twenty-four midwives who all performed obstetric ultrasound examinations were recruited for focus group discussions and individual interviews. Data collection took place in 2015 in five hospitals in two different regions of Norway. Data were analyzed using qualitative content analysis.

    Results: Midwives described obstetric ultrasound examinations as very valuable although doing ultrasounds placed high demands on their operational and counselling skills. Increasing requests for ultrasound from pregnant women were mentioned. Advancements in ultrasound diagnosis were considered to have put the fetus in the position of a patient, and that pregnant women declining ultrasound could be viewed as irresponsible by some health professionals. Ethical concerns were raised regarding the possibility of pregnancy termination when fetal anomalies were detected. Fears were also expressed that prenatal diagnoses including those following ultrasound, might create a society where only perfect' children are valued. However, participants stressed that their intention in performing ultrasound was to optimize pregnancy outcome and thereby assist expectant couples and their unborn children.

    Conclusions: Midwives in Norwegian maternity care services describe obstetric ultrasound as very valuable, playing a central role in pregnancy management by optimizing pregnancy outcomes. Although high demands are placed on operators' technical skills and counseling, midwives described performing obstetric ultrasound as very satisfying work. However, midwives believed that expectant parents' approach to the ultrasound examination, both its medical value and the precious images obtained of the fetus, could put extra strain on the midwives performing ultrasounds. The potential of ultrasound to detect fetal anomalies and the possibility that this may lead to termination of pregnancy, seemed to create some ambivalent feelings in midwives towards its use.

  • Zhao, Hongxing
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools.
    Chen, Maoshan
    Monash Univ, Cent Clin Sch, Australian Ctr Blood Dis, Clayton, Vic, Australia.
    Valdes, Alberto
    Univ Alcala De Henares, Dept Analyt Chem Phys Chem & Chem Engn, Madrid, Spain.
    Lind, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Pettersson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Transcriptomic and proteomic analyses reveal new insights into the regulation of immune pathways during adenovirus type 2 infection2019In: BMC Microbiology, ISSN 1471-2180, E-ISSN 1471-2180, Vol. 19, article id 15Article in journal (Refereed)
    Abstract [en]

    Background: Human adenovirus (Ad) infection leads to the changes of host cell gene expression and biosynthetic processes. Transcriptomics in adenovirus type 2 (Ad2)-infected lung fibroblasts (IMR-90) cells has previously been studied using RNA sequencing. However, this study included only two time points (12 and 24 hpi) using constrained 76bp long sequencing reads. Therefore, a more detailed study of transcription at different phases of infection using an up-graded sequencing technique is recalled. Furthermore, the correlation between transcription and protein expression needs to be addressed.

    Results: In total, 3556 unique cellular genes were identified as differentially expressed at the transcriptional level with more than 2-fold changes in Ad2-infected cells as compared to non-infected cells by using paired-end sequencing. Based on the kinetics of the gene expression changes at different times after infection, these RNAs fell into 20 clusters. Among them, cellular genes involved in immune response were highly up-regulated in the early phase before becoming down-regulated in the late phase. Comparison of differentially expressed genes at transcriptional and posttranscriptional levels revealed low correlation. Particularly genes involved in cellular immune pathways showed a negative correlation. Here, we highlight the genes which expose inconsistent expression profiles with an emphasis on key factors in cellular immune pathways including NFB, JAK/STAT, caspases and MAVS. Different from their transcriptional profiles with up- and down-regulation in the early and late phase, respectively, these proteins were up-regulated in the early phase and were sustained in the late phase. A surprising finding was that the target genes of the sustained activators failed to show response.

    Conclusion: There were features common to genes which play important roles in cellular immune pathways. Their expression was stimulated at both RNA and protein levels during the early phase. In the late phase however, their transcription was suppressed while protein levels remained stable. These results indicate that Ad2 and the host cell use different strategies to regulate cellular immune pathways. A control mechanism at the post-translational level must thus exist which is under the control of Ad2.

  • Nardi, F.
    et al.
    Univ Foreigners Perugia, Water Resources Res & Documentat Ctr WARREDOC, Perugia, Italy.
    Annis, A.
    Univ Foreigners Perugia, Water Resources Res & Documentat Ctr WARREDOC, Perugia, Italy.
    Di Baldassarre, Giuliano
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. CNDS, Ctr Nat Hazards & Disaster Sci, Uppsala, Sweden;IHE Delft Inst Water Educ, Delft, Netherlands.
    Vivoni, E. R.
    Arizona State Univ, Sch Earth & Space Explorat, Tempe, AZ USA;Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA.
    Grimaldi, S.
    Univ Tuscia, Dept Innovat Biol Agrofood & Forest Syst DIBAF, Viterbo, Italy;NYU, Tandon Sch Engn, Dept Mech & Aerosp Engn, New York, NY USA.
    GFPLAIN250m, a global high-resolution dataset of Earth's floodplains2019In: Scientific Data, E-ISSN 2052-4463, Vol. 6, article id 180309Article in journal (Refereed)
    Abstract [en]

    Identifying floodplain boundaries is of paramount importance for earth, environmental and socioeconomic studies addressing riverine risk and resource management. However, to date, a global floodplain delineation using a homogeneous procedure has not been constructed. In this paper, we present the first, comprehensive, high-resolution, gridded dataset of Earth's floodplains at 250-m resolution (GFPLAIN250m). We use the Shuttle Radar Topography Mission (SRTM) digital terrain model and set of terrain analysis procedures for geomorphic floodplain delineations. The elevation data are processed by a fast geospatial tool for floodplain mapping available for download at https://github.com/fnardi/GFPLAIN. The GFPLAIN250m dataset can support many applications, including flood hazard mapping, habitat restoration, development studies, and the analysis of human-flood interactions. To test the GFPLAIN250m dataset, we perform a consistency analysis with floodplain delineations derived by flood hazard modelling studies in Europe.

  • Al-Mashhadi, Ammar
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Häggman, Michael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Läckgren, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Ladjevardi, Sam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Nevéus, Tryggve
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Stenberg, Arne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Persson, A. Erik G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Carlstrom, Mattias
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
    Changes of arterial pressure following relief of obstruction in adults with hydronephrosis2018In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 4, p. 216-224Article in journal (Refereed)
    Abstract [en]

    Background: As much as 20% of all cases of hypertension are associated with kidney malfunctions. We have previously demonstrated in animals and in pediatric patients that hydronephrosis causes hypertension, which was attenuated by surgical relief of the ureteropelvic junction (UPJ) obstruction. This retrospective cohort study aimed to investigate: (1) the proposed link between hydronephrosis, due to UPJ obstruction, and elevated arterial pressure in adults; and (2) if elevated blood pressure in patients with hydronephrosis might be another indication for surgery.

    Materials and methods: Medical records of 212 patients undergoing surgical management of hydronephrosis, due to UPJ obstruction, between 2000 and 2016 were assessed. After excluding patients with confounding conditions and treatments, paired arterial pressures (i.e. before/after surgery) were compared in 49 patients (35 years old; 95% CI 29–39). Split renal function was evaluated by using mercaptoacetyltriglycine (MAG3) renography before surgical management of the hydronephrotic kidney.

    Results: Systolic (−11 mmHg; 95% CI 6–15 mmHg), diastolic (−8 mmHg; 95% CI 4–11 mmHg), and mean arterial (-9 mmHg; 95% CI 6–12) pressures were significantly reduced after relief of the obstruction (p < 0.001). Split renal function of the hydronephrotic kidney was 39% (95% CI 37–41). No correlations were found between MAG3 and blood pressure level before surgery or between MAG3 and the reduction of blood pressure after surgical management of the UPJ obstruction.

    Conclusions: In adults with hydronephrosis, blood pressure was reduced following relief of the obstruction. Our findings suggest that elevated arterial pressure should be taken into account as an indication to surgically correct hydronephrosis.

  • Eckman, Oscar
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Ericsson, Oskar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Korruption och bistånd: En studie om korruptionsnivåns påverkan på bistånd2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Korruption utmålas av biståndsorgan som ett av de största hoten mot ett lands utveckling. Detär inte endast ett problem i sig självt, utan korruption genererar även andra samhällsproblem.Detta gör att anti-korruptionsarbete är på agendan för många biståndsgivare, då ett lyckatresultat kan leda till förbättringar inom många områden. I teorin låter det som att länder medhög korruption bör få hjälp att stävja denna, men är det så i praktiken? Denna studieundersöker hur mottagarländernas korruptionsnivå påverkar biståndet de mottar, genom enfixed effects-regression av paneldata över 79 länder för åren 2005 till 2016. Resultaten visaringen statistisk signifikant effekt av mottagarländernas korruptionsnivå på dess bistånd.Däremot går det att säkerställa att korruptionsnivån påverkar Sveriges bilaterala bistånd.

  • Halldorsdottir, Sandra
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Dahlstrand, Hanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Stålberg, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Gynecologists are afraid of prescribing hormone replacement to endometrial/ovarian cancer survivors despite national guidelines-a survey in Sweden2018In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 4, p. 225-229Article in journal (Refereed)
    Abstract [en]

    Background: Prolonged survival in ovarian and endometrial cancer patients increases the importance of paying attention to quality of life. Hormone replacement therapy (HRT) after gynecologic cancer has been controversial. With this survey, we sought to describe Swedish gynecologists’ and gynecologic oncologists’ attitudes towards prescribing HRT to these cancer survivors and see if prescribing practice is consistent with the available evidence and national guidelines.

    Material and methods: A web-based survey containing three hypothetical cases with a total of 15 questions was distributed to gynecologists and gynecologic oncologists in Sweden. Respondents were asked about their HRT prescription practices in endometrial/ovarian cancer patients with moderate to severe menopausal symptoms.

    Results: In total 262 gynecologists and 24 gynecologic oncologists answered the survey. In the low-risk endometrial cancer case a majority of the gynecologists (55%) and gynecologic oncologists (66.7%) would prescribe local estrogen. A total of 30% of the gynecologists would prescribe estrogen replacement therapy (ERT) in the high-risk endometrial cancer case compared to 58.3% of the gynecologic oncologists. The gynecologic oncologists felt more comfortable treating patients with endometrial cancer than did gynecologists, and the gynecologists were more likely to read the national guidelines. In the ovarian cancer case, 63.7% of the gynecologists would prescribe HRT compared to 92% of the gynecologic oncologists.

    Conclusion: Swedish gynecologic oncologists have a more favorable attitude towards HRT for endometrial/ovarian cancer patients and feel more comfortable treating their patients than do gynecologists. This study illustrates a need for education in these matters in order not to withhold HRT from women due to doctors’ sometimes unjustified anxiety.

  • Amaratunga, Chanaki
    et al.
    NIAID, Lab Malaria & Vector Res, Div Intramural Res, NIH, Rockville, MD USA.
    Andrianaranjaka, Voahangy Hanitriniaina
    Inst Pasteur Madagascar, Malaria Res Unit, Antananarivo, Madagascar;Univ Antananarivo, Fac Sci, Antananarivo, Madagascar.
    Ashley, Elizabeth
    MOCRU, Yangon, Myanmar;Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England.
    Bethell, Delia
    Armed Forces Res Inst Med Sci, Bangkok, Thailand.
    Bjorkman, Anders
    Karolinska Inst, Dept Mol Tumor & Cell Biol, Stockholm, Sweden.
    Bonnington, Craig A.
    Shoklo Malaria Res Unit, Mae Sot, Thailand.
    Cooper, Roland A.
    Dominican Univ Calif, Dept Nat Sci & Math, San Rafael, CA USA.
    Dhorda, Mehul
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England.
    Dondorp, Arjen
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England;Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand.
    Erhart, Annette
    ITM Antwerp, Dept Publ Hlth, Antwerp, Belgium;Inst Trop Med, MRC Unit Gambia, Fajara, Gambia;Inst Trop Med, MRC Unit Gambia, Fajara, Gambia.
    Fairhurst, Rick M.
    NIAID, Lab Malaria & Vector Res, Div Intramural Res, NIH, Rockville, MD USA.
    Faiz, Abul
    Dev Care Fdn, Dhaka, Bangladesh.
    Fanello, Caterina
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Mahidol Oxford Res Unit, Bangkok, Thailand.
    Fukuda, Mark M.
    Armed Forces Res Inst Med Sci, Bangkok, Thailand.
    Guerin, Philippe
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England.
    van Huijsduijnen, Rob Hooft
    Med Malaria Venture, Geneva, Switzerland.
    Hien, Tran Tinh
    Hong, N. V.
    Natl Inst Malariol Parasitol & Entomol, Hanoi, Vietnam.
    Htut, Ye
    Dept Med Res, Yangon, Myanmar.
    Huang, Fang
    Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai, Peoples R China.
    Humphreys, Georgina
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England.
    Imwong, Mallika
    Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
    Kennon, Kalynn
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England.
    Lim, Pharath
    NIAID, Lab Malaria & Vector Res, Div Intramural Res, NIH, Rockville, MD USA.
    Lin, Khin
    Dept Med Res, Pyin Oo Lwin Branch, Anesakhan, Myanmar.
    Lon, Chanthap
    Armed Forces Res Inst Med Sci, Bangkok, Thailand.
    Mårtensson, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Mayxay, Mayfong
    Lao Oxford Mahosot Hospital, Wellcome Trust Res Unit, LOMWRU, Viangchan, Laos;Univ Hlth Sci, Minist Hlth, Fac Postgrad Studies, Viangchan, Laos;Churchill Hosp, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England.
    Mokuolu, Olugbenga
    Univ Ilorin, Coll Hlth Sci, Dept Paediat & Child Hlth, Ilorin, Nigeria;Univ Ilorin, Teaching Hosp, Ctr Malaria & Other Trop Dis Care, Ilorin, Nigeria.
    Morris, Ulrika
    Karolinska Inst, Dept Mol Tumor & Cell Biol, Stockholm, Sweden.
    Ngasala, Billy E.
    Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania.
    Amambua-Ngwa, Alfred
    Inst Trop Med, MRC Unit Gambia, Fajara, Gambia.
    Noedl, Harald
    Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.
    Nosten, Francois
    Shoklo Malaria Res Unit, Mae Sot, Thailand;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
    Onyamboko, Marie
    Mahidol Oxford Res Unit, Bangkok, Thailand;Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO.
    Phyo, Aung Pyae
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
    Plowe, Christopher V.
    Duke Univ, Duke Global Hlth Inst, Durham, NC USA.
    Pukrittayakamee, Sasithon
    Mahidol Univ, Dept Clin Trop Med, Bangkok, Thailand;Royal Soc Thailand, Bangkok, Thailand.
    Randrianarivelojosia, Milijaona
    Inst Pasteur Madagascar, Malaria Res Unit, Antananarivo, Madagascar;Univ Toliara, Fac Sci, Toliara, Madagascar.
    Rosenthal, Philip J.
    Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA;Univ Calif San Francisco, Div HIV Infect Dis & Global Med, San Francisco, CA 94143 USA.
    Saunders, David L.
    Armed Forces Res Inst Regenerat Med, Bangkok, Thailand;US Army Med Mat Dev Act, Ft Detrick, MD USA.
    Sibley, Carol Hopkins
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England;Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
    Smithuis, Frank
    Myanmar Oxford Clin Res Unit, Yangon, Myanmar.
    Spring, Michele D.
    Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok, Thailand.
    Sondo, Paul
    Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, WWARN, Oxford, England;CRUN, Ouaga, Burkina Faso.
    Sreng, Sokunthea
    Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
    Starzengruber, Peter
    Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria;Med Univ Vienna, Dept Lab Med, Div Clin Microbiol, Vienna, Austria.
    Stepniewska, Kasia
    Univ Oxford, Ctr Trop Med & Global Hlth, WWARN, Oxford, England.
    Suon, Seila
    Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
    Takala-Harrison, Shannon
    Univ Maryland, Sch Med, Inst Global Hlth, Div Malaria Res, Baltimore, MD 21201 USA.
    Thriemer, Kamala
    Inst Trop Med, Antwerp, Belgium;Menzies Sch Hlth Res, Darwin, NT, Australia.
    Thuy-Nhien, Nguyen
    Tun, Kyaw Myo
    Myanmar Oxford Clin Res Unit, Yangon, Myanmar;Def Serv Med Acad, Yangon, Myanmar.
    White, Nicholas J.
    Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England.
    Woodrow, Charles
    Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England.
    Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments: a WWARN individual patient data meta-analysis2019In: BMC Medicine, ISSN 1741-7015, E-ISSN 1741-7015, Vol. 17, p. 1-20, article id 1Article in journal (Refereed)
    Abstract [en]

    Background: Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular marker of the slow clearance phenotype has been identified: single genetic changes within the propeller region of the Kelch13 protein (pfk13; Pf3D7_1343700). Global searches have identified almost 200 different non-synonymous mutant pfk13 genotypes. Most mutations occur at low prevalence and have uncertain functional significance. To characterize the impact of different pfk13 mutations on parasite clearance, we conducted an individual patient data meta-analysis of the associations between parasite clearance half-life (PC1/2) and pfk13 genotype based on a large set of individual patient records from Asia and Africa.

    Methods: A systematic literature review following the PRISMA protocol was conducted to identify studies published between 2000 and 2017 which included frequent parasite counts and pfk13 genotyping. Four databases (Ovid Medline, PubMed, Ovid Embase, and Web of Science Core Collection) were searched. Eighteen studies (15 from Asia, 2 from Africa, and one multicenter study with sites on both continents) met inclusion criteria and were shared. Associations between the log transformed PC1/2 values and pfk13 genotype were assessed using multivariable regression models with random effects for study site.

    Results: Both the pfk13 genotypes and the PC1/2 were available from 3250 (95%) patients (n=3012 from Asia (93%), n=238 from Africa (7%)). Among Asian isolates, all pfk13 propeller region mutant alleles observed in five or more specific isolates were associated with a 1.5- to 2.7-fold longer geometric mean PC1/2 compared to the PC1/2 of wild type isolates (all p≤0.002). In addition, mutant allele E252Q located in the P. falciparum region of pfk13 was associated with 1.5-fold (95%CI 1.4-1.6) longer PC1/2. None of the isolates from four countries in Africa showed a significant difference between the PC1/2 of parasites with or without pfk13 propeller region mutations.Previously, the association of six pfk13 propeller mutant alleles with delayed parasite clearance had been confirmed. This analysis demonstrates that 15 additional pfk13 alleles are associated strongly with the slow-clearing phenotype in Southeast Asia.

    Conclusion: Pooled analysis associated 20 pfk13 propeller region mutant alleles with the slow clearance phenotype, including 15 mutations not confirmed previously.

  • Yin, Peng
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Gandasi, Nikhil R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Arora, Swati
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Omar-Hmeadi, Muhmmad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Saras, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Barg, Sebastian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Syntaxin clusters at secretory granules in a munc18-bound conformation2018In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 29, no 22, p. 2700-2708Article in journal (Refereed)
    Abstract [en]

    Syntaxin (stx)-1 is an integral plasma membrane protein that is crucial for two distinct steps of regulated exocytosis, docking of secretory granules at the plasma membrane and membrane fusion. During docking, stx1 clusters at the granule docking site, together with the S/M protein munc18. Here we determined features of stx1 that contribute to its clustering at granules. In live insulin-secreting cells, stx1 and stx3 (but not stx4 or stx11) accumulated at docked granules, and stx1 (but not stx4) rescued docking in cells expressing botulinum neurotoxin-C. Using a series of stx1 deletion mutants and stx1/4 chimeras, we found that all four helical domains (Ha, Hb, Hc, SNARE) and the short N-terminal peptide contribute to recruitment to granules. However, only the Hc domain confers specificity, and it must be derived from stx1 for recruitment to occur. Point mutations in the Hc or the N-terminal peptide designed to interfere with binding to munc18-1 prevent stx1 from clustering at granules, and a mutant munc18 deficient in binding to stx1 does not cluster at granules. We conclude that stx1 is recruited to the docking site in a munc18-1-bound conformation, providing a rationale for the requirement for both proteins for granule docking.

  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio de gustu in artibus elegantioribus quam ... præside Mag. Jac. Fred. Neikter, ... exhibet Benj. Car. Henr. Höijer, Stip. Reg. Vestmannus. In Audit. Gust. Maj. d. XXIII. Dec. MDCCLXXXVI.1786Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Underdånigste tal, holdne i Upsala academie den 15 nov. 1786. då hans kongl. höghet kronprinsen, såsom academiens canceller, nådigast behagade afhöra ompröfningen af de theser, som utgåfvos af Jacob Fredric Neikter, och försvarades af :: Pehr Henric Liljensparre. Upsala, tryckte hos directeuren Johan Edman1786Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Under kongl. maj:ts vistande i Upsala och uti hans kongl. höghets, kronprinsens academiens cancellers höga öfvervaro; Theser, på nådigsta befallning utgifne och försvarade, af Jac. Fred. Neikter, biblioth. och prof. samt Pehr Henr. Liliensparre, den 15 november 1786, i den större gustavianske lärosalen.1786Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores, cujus partem decimam sextam, venia ampliss. fac. philos. Ups. præside mag. Jac. Fred. Neikter, eloqu. et polit. profess. reg. et Skytt. Reg. Acad. Litt. Hum. Hist. et Ant. ut et Reg. Soc. Scient. Ups. membro publice ventilandam sistit Carolus Petrus Hagberg, Uplandus. In audit. Gust. maj. d. 13 Decembris 1797. H. a. m. s., d. 161797Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores, cujus partem decimam quintam, venia ampliss. fac. philos. Ups. præside mag. Jac. Fred. Neikter, eloqu. et polit. profess. reg. et Skytt. Reg. Acad. Litt. Hum. Hist. et Ant. ut et Reg. Soc. Scient. Ups. membro publice ventilandam sistit Samuel Johannes Lind, Borgoa-Fenno. In audit. Gust. maj. d. XXII Martii MDCCXCVII. h. a. m. c., d. 151797Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem decimam quartam venia max. ven. fac. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publice ventilandam sistit Johannes Utterman, Wermlandus in audit. Gust. maj. d. XXII Dec. MDCCXCVI. H. a. m. c., d. 141796Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem decimam tertiam venia ampliss. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publice ventilandam sistit Johannes Olavus Sörling, Stockholmiensis. In audit. Gust. maj. d. XIV Dec. MDCCXCVI. H. a. m. s., d. 131796Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica. De efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem duodecimam venia ampliss. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publice ventilandam sistit Hans Pet. Sandahl, Smolandus. In audit. Gust. maj. d. VII Maji MDCCXCIV. H. a. m. s., d. 121794Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem undecimam, venia ampl. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publico examini subjicit Nicolaus Abrahamus Pihlman, ... In audit. Gust. maj. d. XXI. Dec. MDCCXCIII. H. a. m. s., d. 111793Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem decimam, venia ampl. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publice ventilandam sistit Andreas Hållenstedt, Uplandus. In audit. Gust. maj. d. XIV Dec. MDCCXCIII. H. a. m. s., d. 101793Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio historica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem nonam, venia ampl. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publice ventilandam sistit Olavus Kullberg, Gevalia-Gesticus. In audit. Gust. maj. d. XI Dec. MDCCXCIII. H. a. m. s., d. 91793Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem octavam, venia ampl. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publico proponit examini Nathanaël Kinmanson, ... In audit. Gust. maj. d. XIII Maji MDCCXCI. H. a. m. s., d. 81791Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem septimam, venia ampliss. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publico proponit examini Johannes Ericus Lundgren, Sudermannus. In auditorio Gust. maj. d. XX Dec. MDCCLXXXVIII. H. a. m. s., d. 71788Dissertation (older thesis) (Other academic)
  • Neikter, Jacob Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de efficacia climatum ad variam gentium indolem, præcipue ingenia et mores. Cujus partem sextam, venia ampliss. facult. philos. Ups. Præside mag. Jac. Fred. Neikter,... Publico examini modeste submittit Andreas Wångenberg, OstroGothus. In auditorio Gust. maj. d. XIII Dec. MDCCLXXXVIII. H. a. m. s., d. 61788Dissertation (older thesis) (Other academic)