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  • Forsberg, Love
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Semigroups, multisemigroups and representations2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis consists of four papers about the intersection between semigroup theory, category theory and representation theory. We say that a representation of a semigroup by a matrix semigroup is effective if it is injective and define the effective dimension of a semigroup S as the minimal n such that S has an effective representation by square matrices of size n.

    A multisemigroup is a generalization of a semigroup where the multiplication is set-valued, but still associative.

    A 2-category consists of objects, 1-morphisms and 2-morphisms. A finitary 2-category has finite dimensional vector spaces as objects and linear maps as morphisms. This setting permits the notion of indecomposable 1-morphisms, which turn out to form a multisemigroup.

    Paper I computes the effective dimension Hecke-Kiselman monoids of type A. Hecke-Kiselman monoids are defined by generators and relations, where the generators are vertices and the relations depend on arrows in a given quiver.

    Paper II computes the effective dimension of path semigroups and truncated path semigroups. A path semigroup is defined as the set of all paths in a quiver, with concatenation as multiplication. It is said to be truncated if we introduce the relation that all paths of length N are zero.

    Paper III defines the notion of a multisemigroup with multiplicities and discusses how it better captures the structure of a 2-category, compared to a multisemigroup (without multiplicities).

    Paper IV gives an example of a family of 2-categories in which the multisemigroup with multiplicities is not a semigroup, but where the multiplicities are either 0 or 1. We describe these multisemigroups combinatorially.

    List of papers
    1. Effective Representations of Hecke-Kiselman Monoids of type A
    Open this publication in new window or tab >>Effective Representations of Hecke-Kiselman Monoids of type A
    (English)Manuscript (preprint) (Other academic)
    National Category
    Algebra and Logic
    Identifiers
    urn:nbn:se:uu:diva-327269 (URN)
    Note

    Vidarearbetning av masterarbete med samma titel som ingår i doktorsavhandling

    Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-31
    2. Effective representations of path semigroups
    Open this publication in new window or tab >>Effective representations of path semigroups
    2016 (English)In: Semigroup Forum, ISSN 0037-1912, E-ISSN 1432-2137, Vol. 92, no 2, 449-459 p.Article in journal (Refereed) Published
    Abstract [en]

    We give formulas which determine the effective dimensions of path semigroups over an uncountable field and of truncated path semigroups over a field which is uncountable or of characteristic zero.

    Keyword
    path semigroup, effective dimension, quiver, matrix representation
    National Category
    Algebra and Logic
    Research subject
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-275205 (URN)10.1007/s00233-015-9697-1 (DOI)000372436200007 ()
    Available from: 2016-02-01 Created: 2016-02-01 Last updated: 2017-08-09Bibliographically approved
    3. Multisemigroups with multiplicities and complete ordered semi-rings
    Open this publication in new window or tab >>Multisemigroups with multiplicities and complete ordered semi-rings
    2017 (English)In: Beitraege zur Algebra und Geometrie, ISSN 0138-4821, E-ISSN 2191-0383, Vol. 58, no 2, 405-426 p.Article in journal (Other academic) Published
    Abstract [en]

    Motivated by the apperance of multisemigroups in the study of additive 2-categories, we define and investigate the notion of a multisemigroup with multiplicities. This notion seems to be better siutable for applications in higher representation theory.

    Place, publisher, year, edition, pages
    Berlin: Springer, 2017
    Keyword
    Multi-multisemigroup, multisemigroup, 2-category
    National Category
    Algebra and Logic
    Research subject
    Mathematics
    Identifiers
    urn:nbn:se:uu:diva-275206 (URN)10.1007/s13366-016-0320-8 (DOI)
    Available from: 2016-02-01 Created: 2016-02-01 Last updated: 2017-08-10Bibliographically approved
    4. Sub-bimodules of the identity bimodule for cyclic quivers
    Open this publication in new window or tab >>Sub-bimodules of the identity bimodule for cyclic quivers
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    We describe the combinatorics of the multisemigroup with multiplicities for the tensor category of subbimodules of the identity bimodule, foran arbitrary non-uniform orientation of a finite cyclic quiver

    Keyword
    representation theory, quiver, bimodule, multisemigroup
    National Category
    Algebra and Logic
    Identifiers
    urn:nbn:se:uu:diva-327259 (URN)
    Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-09
  • Målqvist, Mats
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Pun, Asha
    UN Health Section, UNICEF, Nepal.
    Raaijmakers, Hendrikus
    UN Health Section, UNICEF, Nepal.
    KC, Ashish
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH). UN Health Section, UNICEF, Nepal.
    Persistent inequity in maternal health care utilization in Nepal despite impressive overall gains2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, no 1, 1356083Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Maternal health care utilization is at the core of global public health provision and an area of focus in the now-concluded Millennium Development Goal agenda.

    OBJECTIVE: This study aims to examine trends in maternal health care utilization over the last 15 years in Nepal, focusing on coverage and equity.

    METHODS: This paper used data from the Demographic Health Survey (DHS) 2001, 2006 and 2011 and Multiple Indicator Cluster Survey (MICS), 2014. Coverage rates were calculated and logistic regression models used to examine inequity.

    RESULTS: Impressive gains were found in antenatal care (ANC) attendance, which increased from nearly half of women attending (49%) in 2001 to 88% in 2014, and the rate of facility delivery increased from just 7-44%. This development did not, however, influence the equity gap in ANC and skilled attendance at birth, as women from low socioeconomic backgrounds were six times more likely to deliver without skilled assistance than those from high socioeconomic backgrounds (AdjOR 6.38 CI 95% 4.57-8.90) in 2014.

    CONCLUSION: These persistent equity gaps call for targeted interventions focusing on the most disadvantaged and vulnerable women in order to achieve the new Sustainable Development Goal of universal health coverage.

  • Thorup, Emilia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala Child & Babylab.
    Joint Attention in Development: Insights from Children with Autism and Infant Siblings2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Compared to other children, children with Autism Spectrum Disorder (ASD) are known to engage less in joint attention - the sharing of attention between two individuals toward a common object or event. Joint attention behaviors - for example gaze following, alternating gaze, and pointing - play an important role in early development, as they provide a foundation for learning and social interaction. Study I and Study II focused on infant siblings of children with ASD. These infants, often termed high risk (HR) infants, have an increased probability of receiving a later ASD diagnosis. Studying them therefore allows for the detection of early signs of ASD. Live eye tracking was used to investigate different joint attention behaviors at 10 months of age. Study I showed that omitting the head movement that usually accompany experimenters’ eye gaze shifts in similar designs reduced gaze following performance in the HR group, but not in a group of infants at low risk (LR) for ASD. HR infants may thus be less sensitive to eye information, or may need more salient cues in order to follow gaze optimally. Study II focused on the infants’ tendency to initiate joint attention by alternating their gaze between a person and an event. LR infants engaged more in alternating gaze than HR infants, and less alternating gaze in infancy was associated with more ASD symptoms at 18 months. This relation remained when controlling for visual disengagement and general social interest in infancy. Study III explored the role of joint attention later in development, by investigating the microstructure of the looking behaviors of autistic and typically developing children (~6 years old). The results indicated that seeing somebody look at an object influenced the processing of that object less in autistic children than in the typically developing controls. Both groups followed gaze effectively, suggesting that differences in joint attention at this age may be subtle, but detectable with eye tracking technology. Together, the studies contribute to our understanding of the role that joint attention atypicalities play both in the early development of infants at risk for ASD, and later in the development of children with a confirmed diagnosis.

    List of papers
    1. Altered gaze following during live interaction in infants at risk for autism: An eye tracking study
    Open this publication in new window or tab >>Altered gaze following during live interaction in infants at risk for autism: An eye tracking study
    Show others...
    2016 (English)In: Molecular Autism, ISSN 2040-2392, Vol. 7, 12Article in journal (Refereed) Published
    Abstract [en]

    Background: The ability to follow gaze is an important prerequisite for joint attention, which is often compromised in children with autism spectrum disorder (ASD). The direction of both the head and eyes provides cues to other people's attention direction, but previous studies have not separated these factors and their relation to ASD susceptibility. Development of gaze following typically occurs before ASD diagnosis is possible, and studies of high-risk populations are therefore important. Methods: Eye tracking was used to assess gaze following during interaction in a group of 10-month-old infants at high familial risk for ASD (high-risk group) as well as a group of infants with no family history of ASD (low-risk group). The infants watched an experimenter gaze at objects in the periphery. Performance was compared across two conditions: one in which the experimenter moved both the eyes and head toward the objects (Eyes and Head condition) and one that involved movement of the eyes only (Eyes Only condition). Results: A group by condition interaction effect was found. Specifically, whereas gaze following accuracy was comparable across the two conditions in the low-risk group, infants in the high-risk group were more likely to follow gaze in the Eyes and Head condition than in the Eyes Only condition. Conclusions: In an ecologically valid social situation, responses to basic non-verbal orienting cues were found to be altered in infants at risk for ASD. The results indicate that infants at risk for ASD may rely disproportionally on information from the head when following gaze and point to the importance of separating information from the eyes and the head when studying social perception in ASD.

    Keyword
    Autism; Gaze following; Joint attention; Early development; Neurodevelopmental disorders; Social cognition; Communication; Younger siblings
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-275580 (URN)10.1186/s13229-016-0069-9 (DOI)000368885200001 ()26819699 (PubMedID)
    Funder
    Swedish Research Council, 259-2012-24Swedish Research Council, 2015-03670Swedish Research Council, 523-2009-7054Riksbankens Jubileumsfond, P12-0270:1Riksbankens Jubileumsfond, NHS14-1802:1EU, European Research Council, 312292
    Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2017-08-05Bibliographically approved
    2. Reduced alternating gaze during social interaction in infancy is associated with elevated symptoms of autism in toddlerhood
    Open this publication in new window or tab >>Reduced alternating gaze during social interaction in infancy is associated with elevated symptoms of autism in toddlerhood
    Show others...
    (English)Article in journal (Refereed) Submitted
    Abstract [en]

    In typical development, infants often alternate their gaze between their interaction partners and interesting stimuli, increasing the probability of joint attention toward surrounding objects and creating opportunities for communication and learning. Children with Autism Spectrum Disorder (ASD) have been found to engage less in behaviors that can initiate joint attention compared to typically developing children, but the role of such atypicalities in the development of ASD during infancy is not fully understood. Here, using eye tracking technology in a live setting, we show that 10-month-olds at high familial risk for ASD engage less in alternating gaze during interaction with an adult compared to low risk infants. These differences could not be explained by low general social preference or slow visual disengagement, as the groups performed similarly in these respects. We also found that less alternating gaze at 10 months was associated with more ASD symptoms and less showing and pointing at 18 months. These relations were similar in both the high risk and the low risk groups, and remained when controlling for general social preference and disengagement latencies. This study shows that atypicalities in alternating gaze in infants at high risk for ASD emerge already during the first 10 months of life - a finding with theoretical as well as potential practical implications.

    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-327116 (URN)
    Available from: 2017-08-03 Created: 2017-08-03 Last updated: 2017-08-11
    3. Gaze Following in Children with Autism: Do High Interest Objects Boost Performance?
    Open this publication in new window or tab >>Gaze Following in Children with Autism: Do High Interest Objects Boost Performance?
    2017 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432, Vol. 47, no 3, 626-635 p.Article in journal (Refereed) Published
    Abstract [en]

    This study tested whether including objects perceived as highly interesting by children with autism during a gaze following task would result in increased first fixation durations on the target objects. It has previously been found that autistic children differentiate less between an object another person attends to and unattended objects in terms of this measure.  Less differentiation between attended and unattended objects in ASD as compared to control children was found in a baseline condition, but not in the high interest condition. However, typically developing children differentiated less between attended and unattended objects in the high interest condition than in the baseline condition, possibly reflecting reduced influence of gaze cues on object processing when objects themselves are highly interesting.

    Keyword
    Gaze following, Joint attention, Circumscribed interests, Communication, Social cognition
    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-313736 (URN)10.1007/s10803-016-2955-6 (DOI)000396815400011 ()27987062 (PubMedID)
    Funder
    Swedish Research Council, 2015-03670Riksbankens Jubileumsfond, NHS14-1802:1The Karolinska Institutet's Research Foundation
    Available from: 2017-01-23 Created: 2017-01-23 Last updated: 2017-08-05Bibliographically approved
  • Nilsson, Rasmus
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    SOPHIE OCH (DEN RATIONELLA?) KÄRLEKEN: Ekonomi och familj i bildandet av ett 1870-talets kärleksäktenskap2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study considers the changing ideals of marriage during the 19th century as reflected in acollection of Swedish bourgeoisie love-letters from the 1870s. Through a combined quantitative andqualitative effort the goal is to establish how adherents to the relatively new ideal of marriage forthe sake of romantic love; thought, wrote and experienced the material aspects of marriage. It alsoaspires to shed light on how traditional family influence on the marital sphere survived the proposedshift in ideals.The study finds that family, economy and shared feelings were themes that dominated the letters.Individuals that adhered to the ideal of romantic love spent considerable time realizing the materialpre-requisites of marriage. This leads to a conclusion that marriage ideals and marriage practiceevolved at different paces. Family influence largely survived the change of ideals through paternalauthority, individual immersion in the family-dominated socio-economic network and aspirations ofthe young to retain the socio-economic status of their elders.

  • Ånäs, Sofia
    A comparative validation of the human variant simulator SIMdrom2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The past decade’s progress in next generation sequencing has drastically decreased

    the price of whole genome and exome sequencing, making it available as a clinical tool

    for diagnosing patients with genetic disease. However, finding a disease-causing

    mutation among millions of non-pathogenic variants in a patient’s genome, is not an

    easy task. Therefore, algorithms for finding variants relevant for clinicians to

    investigate more closely are needed and constantly developed. To test these

    algorithms a software called SIMdrom has been developed to simulate test data. In

    this project, the simulated data is validated through comparison to real genetic data to

    ensure that it is suitable to use as test data. Through ensuring the data’s reliability and

    finding possible improvements, the development of algorithms for finding

    disease-causing mutations can be facilitated. This in-turn could lead to better

    diagnosing-possibilities for clinicians. When visualizing simulated data together with

    real genomes using principal components analysis, it clusters near it’s real

    counterpart. This shows that the simulated data resembles the real genomes.

    Simulated exomes also performed well when used as a part in one of three training

    sets for the classifier in the Prioritization of Exome Data by Image Analysis study.

    Here they perform second best after an in-house data set consisting of real exomes.

    To conclude, the SIMdrom simulated data performs well in both parts of this project.

    Additional tests of its validity should include testing against larger real data sets, an

    improvement possibility could be to implement a simulation option for spiking in

    noise.

  • Ocklind, Henrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Högerpopulistiska partiers politiska inflytande: En komparativ analys av Danmark, Norge och Sverige2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    De tre skandinaviska länderna Danmark, Norge och Sverige har samtliga ett högerpopulistiskt parti i de nationella parlamenten. Inflytandet som partierna har fått över den nationella politiken skiljer dem åt, i Danmark agerar Dansk Folkeparti stödparti till regeringen och i Norge sitter Fremskrittspartiet i regeringen. I Sverige däremot har Sverigedemokraterna inte fått något direkt inflytande över regeringens politik, trots att partierna är lika stora. 

    Studien har tittat på tre olika variabler utifrån teorin om att högerpopuistiska partier som närmar sig mitten har lättare att samarbeta med andra partier än de som väljer ena sidan, vilket har varit den beroende variabeln. Genom att analysera partiernas politiska program från två tidpunkter går det att se om partierna har anpassat sin politik för att ligga närmare de andra partierna. Även ländernas historia av politiska koalitioner och andra partier i parlamenten har undersökts, vilka har varit de oberoende variablerna. 

    Studiens resultat visar att partierna inte har närmat sig mitten. Dansk Folkeparti har en stark högerprofil i sociokulturella frågor och står i mitten i socioekonomiska frågor. Fremskrittspartiet har haft och har en tydlig högerpolitik i både socioekonomiska och sociokulturella frågor. Sverigedemokraterna har haft ett stort fokus på de sociokulturella frågorna där de står till höger, men har även fått en större socioekonomisk politik, där de står i mitten. Därför går det inte att säga att partier som närmar sig mitten lättare kan samarbeta och få ett större politiskt inflytande. 

  • Af Petersens, Jennifer
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Clason, Alicja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Äldres rapporterade tilltro till egen handlingsförmåga, avsikt och handlingsplanering för att äta enligt Livsmedelsverkets kostråd för frukt och grönsaker samt fisk2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Sverige har ett växande antal äldre medborgare vars medellivslängd ökar. Det blir allt viktigare att förebygga ohälsosamma matvanor hos äldre för att de ska kunna leva inte bara längre, utan också friskare liv så långt det är möjligt.

    Syfte: Syftet var att undersöka äldres kännedom om och följsamhet till Livsmedelsverkets kostråd för frukt och grönsaker samt fisk. Vidare var syftet att undersöka den rapporterade tilltron till egen handlingsförmåga, avsikt och handlingsplanering hos äldre i ordinärt boende att äta enligt dessa kostråd samt om det finns samband mellan samtliga ovan nämnda faktorer.

    Metod: Kvantitativ pappers och webbenkät delades ut efter ett bekvämlighetsurval. Tre ovannämnda faktorer av beteendeförändringsmodellen Health Action Process Approach (HAPA) undersöktes.

    Resultat: Enkäten besvarades av 210 personer. En stark majoritet (82,5%) hade kännedom om varför rekommendationer finns för frukt och grönt samt för fisk (87%). Endast ett fåtal (6%) rapporterade att de följde Livsmedelsverkets rekommendation om 5 portioner frukt och grönt per dag. Samtidigt rapporterade över hälften (52%) att de följde den rekommenderade mängden 2-3 portioner fisk i veckan. En majoritet av respondenterna angav att de hade en avsikt och även tilltro till egen handlingsförmåga att äta både frukt och grönt och fisk enligt rekommendationerna. Av respondenterna angav 43 % att de planerar för att äta frukt och grönt enligt rekommendationen om 5 portioner per dag och 50 % angav att de planerar för att äta fisk enligt rekommendationen om 2-3 portioner per vecka. Sambanden var svaga och positiva. Sex av dessa var statistiskt signifikanta (p<0,001).

    Slutsats: Majoriteten av de äldre rapporterade att de hade kännedom om kostråden samtidigt var det färre som rapporterade att de följde dessa. Majoriteten av de äldre har en hög rapporterad tilltro till egen handlingsförmåga och en hög rapporterad avsikt att äta enligt kostråden för både frukt och grönt samt fisk, men det var färre äldre som rapporterade att de handlingsplanerade för det. De svaga och positiva sambanden visar att det i princip inte fanns någon korrelation mellan faktorerna. En mera omfattande studie behövs för att undersöka om stärkande av respondenternas handlingsplanering skulle få flera att följa kostråden.

  • Marklund, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Control of a high temperature DLTS setup2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis deals with a DLTS-setup and how this can be controlled. The controlling program is constructed in LABVIEW, where a previous built program measuring transients at varying pulses been handled and tried to be implemented for this setup. Parts of the program was implemented successfully, other part needs more work. The heater in the setup has further been connected directly to the sample. This one has been tested to see that the setup can handle the heat and that the difference between the temperature at the sample and the setup did not differ too much. The result showed that the difference was not so big. Finally, DLTS tests was performed at samples of silicon carbide as well as on diamond, where transients could be measured up to 723 °C on the silicon carbide sample, while the tests of diamond only gave noise. 

  • Perland, Emelie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Pharmaceutical Biosciences, Molecular neuropharmacology, Uppsala University.
    Atypical Solute Carriers: Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Solute carriers (SLCs) constitute the largest family of membrane-bound transporter proteins in humans, and they convey transport of nutrients, ions, drugs and waste over cellular membranes via facilitative diffusion, co-transport or exchange. Several SLCs are associated with diseases and their location in membranes and specific substrate transport makes them excellent as drug targets. However, as 30 % of the 430 identified SLCs are still orphans, there are yet numerous opportunities to explain diseases and discover potential drug targets. Among the novel proteins are 29 atypical SLCs of major facilitator superfamily (MFS) type. These share evolutionary history with the remaining SLCs, but are orphans regarding expression, structure and/or function. They are not classified into any of the existing 52 SLC families. The overall aim in this thesis was to study the atypical SLCs with a focus on their phylogenetic clustering, evolutionary conservation, structure, protein expression in mouse brains and if and how their gene expressions were affected upon changed food intake. In Papers I-III, the focus was on specific proteins, MFSD5 and MFSD11 (Paper I), MFSD1 and MFSD3 (Paper II), and MFSD4A and MFSD9 (Paper III). They all shared neuronal expression, and their transcription levels were altered in several brain areas after subjecting mice to food deprivation or a high-fat diet. In Paper IV, the 29 atypical SLCs of MFS type were examined. They were divided into 15 families, based on phylogenetic analyses and sequence identities, to facilitate functional studies. Their sequence relationships with other SLCs were also established. Some of the proteins were found to be well conserved with orthologues down to nematodes and insects, whereas others emerged at first in vertebrates. The atypical SLCs of MFS type were predicted to have the common MFS structure, composed of 12 transmembrane segments. With single-cell RNA sequencing and in situ proximity ligation assay, co-expression of atypical SLCs was analysed to get a comprehensive understanding of how membrane-bound transporters interact.

     

    In conclusion, the atypical SLCs of MFS type are suggested to be novel SLC transporters, involved in maintaining nutrient homeostasis through substrate transport.

    List of papers
    1. The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis
    Open this publication in new window or tab >>The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis
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    2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 6, e0156912Article in journal (Refereed) Published
    Abstract [en]

    Background Solute carriers (SLCs) are membrane bound transporters responsible for the movement of soluble molecules such as amino acids, ions, nucleotides, neurotransmitters and oligopeptides over cellular membranes. At present, there are 395 SLCs identified in humans, where about 40% are still uncharacterized with unknown expression and/or function(s). Here we have studied two uncharacterized atypical SLCs that belong to the Major Facilitator Superfamily Pfam clan, Major facilitator superfamily domain 5 (MFSD5) and Major facilitator superfamily domain 11 (MFSD11). We provide fundamental information about the histology in mice as well as data supporting their disposition to regulate expression levels to keep the energy homeostasis. Results In mice subjected to starvation or high-fat diet, the mRNA expression of Mfsd5 was significantly down-regulated (P<0.001) in food regulatory brain areas whereas Mfsd11 was significantly up-regulated in mice subjected to either starvation (P<0.01) or high-fat diet (P< 0.001). qRT-PCR analysis on wild type tissues demonstrated that both Mfsd5 and Mfsd11 have a wide central and peripheral mRNA distribution, and immunohistochemistry was utilized to display the abundant protein expression in the mouse embryo and the adult mouse brain. Both proteins are expressed in excitatory and inhibitory neurons, but not in astrocytes. Conclusions Mfsd5 and Mfsd11 are both affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. Moreover, the first histological mapping of MFSD5 and MFSD11 shows ubiquitous expression in the periphery and the central nervous system of mice, where the proteins are expressed in excitatory and inhibitory mouse brain neurons.

    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-299580 (URN)10.1371/journal.pone.0156912 (DOI)000377561000047 ()27272503 (PubMedID)
    Funder
    Swedish Research CouncilThe Swedish Brain FoundationNovo Nordisk
    Available from: 2016-07-22 Created: 2016-07-22 Last updated: 2017-08-01Bibliographically approved
    2. The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake
    Open this publication in new window or tab >>The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake
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    2017 (English)In: Journal of Molecular Neuroscience, ISSN 0895-8696, E-ISSN 1559-1166, Vol. 61, no 2, 199-214 p.Article in journal (Refereed) Published
    Abstract [en]

    Membrane-bound solute carriers (SLCs) are essential as they maintain several physiological functions, such as nutrient uptake, ion transport and waste removal. The SLC family comprise about 400 transporters, and we have identified two new putative family members, major facilitator superfamily domain containing 1 (MFSD1) and 3 (MFSD3). They cluster phylogenetically with SLCs of MFS type, and both proteins are conserved in chordates, whileMFSD1 is also found in fruit fly. Based on homology modelling, we predict 12 transmembrane regions, a common feature for MFS transporters. The genes are expressed in abundance in mice, with specific protein staining along the plasma membrane in neurons. Deprivingm ouse embryonic primary cortex cells of amino acids resulted in upregulation of Mfsd1, whereas Mfsd3 is unaltered. Furthermore, in vivo, Mfsd1 and Mfsd3 are down-regulated in anterior brain sections in mice subjected to starvation, while upregulated specifically in brainstem. Mfsd3 is also attenuated in cerebellum after starvation. In mice raised on high-fat diet, Mfsd1 was specifically downregulated in brainstem and hypothalamus, while Mfsd3 was reduced consistently throughout the brain.

    Place, publisher, year, edition, pages
    HUMANA PRESS INC, 2017
    Keyword
    MFSD1, MFSD3, SLC, Protein expression
    National Category
    Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
    Identifiers
    urn:nbn:se:uu:diva-320771 (URN)10.1007/s12031-016-0867-8 (DOI)000396263800008 ()27981419 (PubMedID)
    Funder
    Swedish Research CouncilThe Swedish Brain FoundationSwedish Society for Medical Research (SSMF)Novo Nordisk
    Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-08-01Bibliographically approved
    3. Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice
    Open this publication in new window or tab >>Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    Keyword
    MFSD4A, MFSD9, solute carrier, major facilitator superfamily, transporter, homology models, protein expression, nutrition.
    National Category
    Neurosciences
    Identifiers
    urn:nbn:se:uu:diva-326695 (URN)
    Available from: 2017-08-01 Created: 2017-08-01 Last updated: 2017-08-02
    4. Characteristics of 29 novel atypical SLCs of MFS type: evolutionary conservation, predicted structure and neuronal co-expression
    Open this publication in new window or tab >>Characteristics of 29 novel atypical SLCs of MFS type: evolutionary conservation, predicted structure and neuronal co-expression
    2017 (English)In: Open Biology, ISSN 2046-2441, E-ISSN 2046-2441, Vol. 7, no 8Article in journal (Refereed) In press
    Abstract [en]

    Solute carriers (SLCs) are vital as they are responsible for a major part of the molecular transport over lipid bilayers. At present, there are 430 identified SLCs, of which 28 are called atypical SLCs of major facilitator superfamily (MFS) type. These are MFSD1, 2A, 2B, 3, 4A, 4B, 5, 6, 6L, 7, 8, 9, 10, 11, 12, 13A, 14A, 14B; SV2A, SV2B, SV2C, SVOP, SVOPL; SPNS1, SPNS2, SPNS3; UNC93A and UNC93B1, and we studied their fundamental properties. We also included CLN3, an atypical SLC not yet belonging to any Pfam clan, because its involvement in the same neuronal degenerative disorders as MFSD8. With phylogenetic analyses and bioinformatic sequence comparisons, the proteins were divided into 15 families, denoted Atypical MFS Transporter Families (AMTF1-15). Hidden Markov models were used to identify orthologues from human to D.melanogaster and C.elegans. Topology predictions revealed 12 transmembrane segments (for all except CLN3), corresponding to the common MFS structure. With single-cell RNA sequencing and in situ proximity ligation assay on brain cells, co-expressions of several atypical SLC were identified. Finally, the transcription levels of all genes were analysed in the hypothalamic N25/2 cell line after complete amino acid starvation, showing altered expression levels for several atypical SLCs. 

    Keyword
    Major facilitator superfamily, solute carrier, atypical SLC, family clustering, topology, nutrition
    National Category
    Neurosciences
    Identifiers
    urn:nbn:se:uu:diva-326696 (URN)10.1098/rsob.170142 (DOI)
    Available from: 2017-07-28 Created: 2017-07-28 Last updated: 2017-08-03Bibliographically approved
  • Näsvall, Joakim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 8, e0184126Article in journal (Refereed)
    Abstract [en]

    The need for generating precisely designed mutations is common in genetics, biochemistry, and molecular biology. Here, I describe a new λ Red recombineering method (Direct and Inverted Repeat stimulated excision; DIRex) for fast and easy generation of single point mutations, small insertions or replacements as well as deletions of any size, in bacterial genes. The method does not leave any resistance marker or scar sequence and requires only one transformation to generate a semi-stable intermediate insertion mutant. Spontaneous excision of the intermediate efficiently and accurately generates the final mutant. In addition, the intermediate is transferable between strains by generalized transductions, enabling transfer of the mutation into multiple strains without repeating the recombineering step. Existing methods that can be used to accomplish similar results are either (i) more complicated to design, (ii) more limited in what mutation types can be made, or (iii) require expression of extrinsic factors in addition to λ Red. I demonstrate the utility of the method by generating several deletions, small insertions/replacements, and single nucleotide exchanges in Escherichia coli and Salmonella enterica. Furthermore, the design parameters that influence the excision frequency and the success rate of generating desired point mutations have been examined to determine design guidelines for optimal efficiency.

  • Edin, Martin
    et al.
    Erlanson, Nils
    Mathematical modeling of interactions between colonic crypts.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Nordin, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Relational Destination Development: Case Studies on the Significance of Tourism Networks2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Destination development has become a key issue in local and regional development. In particular, many governments recognize the industry's potential for fostering economic growth and development. The tourist destination is often conceptualized as a complex network with several levels of interaction – both networks of actors within the destination, but also networks linking it to its surrounding environment with potential and actual customers, other destinations, government bodies and so on. It is hence the assumption here that we cannot fully understand destination development in a particular community unless we have a good understanding of how the key stakeholders interact.

    By applying different network approaches that are based upon and united by a relational economic geography perspective to the study of destination development, we can widen our understanding of why some destinations struggle to survive and often decline, others maintain a threshold of success as tourist visiting areas, whereas there are still others, which exhibit a high level of competitiveness with local entrepreneurial milieus characterized by growth and long-term development.

    More generally, this thesis deals with a traditional core issue in economic geography, i.e., to explain what it is that makes a place or region characterized by growth and development. This thesis explores this issue, and expands our knowledge on the links between various types of network structures and growth in a destination context, as demonstrated by case studies of two successful tourism areas. These studies of the Swedish mountain resort of Åre, and of Icehotel in northern Sweden, explore relational destination development and the significance of tourism networks.

    List of papers
    1. Social capital and the life cycle model: The transformation of the destination of Åre
    Open this publication in new window or tab >>Social capital and the life cycle model: The transformation of the destination of Åre
    2009 (English)In: Tourism, ISSN 1332-7461, Vol. 57, no 3, 259-284 p.Article, review/survey (Refereed) Published
    Abstract [en]

    This article analyzes the development of the Swedish tourism destination of Åre and its transformation from one of many mountain villages into Scandinavia’s leading alpine ski resort. In reference to Butler’s life cycle model, this evolution is analyzed and some historical turning points in Åre’s development identified. The role of social capital is added to the historical analysis, based on the assumption that there is a link between a destination’s development and its ability to reproduce its social capital. The analysis shows that the social capital at the early stage was, to a large extent, built by and around local actors which predominated the village. The transformation to an international ski resort was possible only by the entrance of new actors, increasingly from the national and international arenas. These new actors have largely come to play leading roles in Åre’s development. At the same time, the new actors’ different values and networks have impacted Åre’s social capital.

    Keyword
    Tourism, Turism, turismforskning
    National Category
    Economics and Business
    Identifiers
    urn:nbn:se:uu:diva-327326 (URN)
    Available from: 2010-01-12 Created: 2017-08-09 Last updated: 2017-08-09Bibliographically approved
    2. Innovative destination governance: The Swedish ski resort of Åre
    Open this publication in new window or tab >>Innovative destination governance: The Swedish ski resort of Åre
    2007 (English)In: International Journal of Entrepreneurship and Innovation, ISSN 1465-7503, E-ISSN 2043-6882, Vol. 8, no 1, 53-66 p.Article in journal (Refereed) Published
    Abstract [en]

    This article explores the impact of governance on destination development, focusing on public-private relations, formal and informal networks as well as resource dependencies. The empirical contribution is based on a single case study of the Swedish ski resort of Åre. In the concluding section, some of the results are developed into suggestions about if and how the governance structure matters in terms of performance. The results indicate that trustful public-private relations, joint risk-taking, informal structures and strategic consensus can have a positive impact on the level of growth in a destination.

    Keyword
    Governance, public-private networks, destination development, growth, innovation.
    National Category
    Social and Economic Geography Political Science (excluding Public Administration Studies and Globalization Studies)
    Identifiers
    urn:nbn:se:uu:diva-327327 (URN)10.5367/000000007780007416 (DOI)
    Available from: 2008-09-30 Created: 2017-08-09 Last updated: 2017-08-09Bibliographically approved
    3. Destination Governance Transitions in the Evolution of Mountain Resorts
    Open this publication in new window or tab >>Destination Governance Transitions in the Evolution of Mountain Resorts
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Social Sciences
    Identifiers
    urn:nbn:se:uu:diva-327328 (URN)
    Available from: 2017-08-09 Created: 2017-08-09 Last updated: 2017-08-09
    4. A Cluster Approach to Destination Development - Network Structures and Contextual Factors in the Evolution of the Mountain Resort of Åre, Sweden
    Open this publication in new window or tab >>A Cluster Approach to Destination Development - Network Structures and Contextual Factors in the Evolution of the Mountain Resort of Åre, Sweden
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Social Sciences
    Identifiers
    urn:nbn:se:uu:diva-327329 (URN)
    Available from: 2017-08-09 Created: 2017-08-09 Last updated: 2017-08-09
    5. Doing, Using, Interacting - Towards a New Understanding of Tourism Innovation Processes
    Open this publication in new window or tab >>Doing, Using, Interacting - Towards a New Understanding of Tourism Innovation Processes
    2017 (English)In: Driving tourism through creative destinations and activities / [ed] A. Kiralova, IGI Global , 2017Chapter in book (Refereed)
    Abstract [en]

    Innovation is a critical factor for long-term economic development, also in tourism. Based on two commonly referred to modes of innovation (Jensen et al., 2007), that is, two types of innovation processes: Science, Technology and Innovation (STI) and Doing, Using and Interacting (DUI), this chapter examines the processes that lead to new products and services in a tourism context. Based on this, DUI seems to capture the essence of innovation in tourism enterprises better than STI, as it acknowledges the intrinsic nature of services and the typical size and working modes of touristic actors. The case study of Icehotel furthermore, illustrates how working in partnerships and in close cooperation with customers enhances the advantages of the DUI model. The handling of externally induced events and difficulties and the critical partnerships are better understood through the DUI than the STI lens. The DUI-framework leads to a more correct picture of tourism innovation, and could also provide a better guidance for policy processes in the field. 

    Place, publisher, year, edition, pages
    IGI Global, 2017
    Keyword
    Innovation Process, Innovation Management, Tourism Innovation, Modes of Innovation, Doing Using Interacting-Mode, DUI, Knowledge, Networks, Customer-driven Innovation, Open Innovation, Icehotel
    National Category
    Social Sciences
    Identifiers
    urn:nbn:se:uu:diva-327330 (URN)10.4018/978-1-5225-2016-0.ch008 (DOI)9781522520160 (ISBN)9781522520177 (ISBN)
    Available from: 2017-08-09 Created: 2017-08-09 Last updated: 2017-08-09Bibliographically approved
  • Clement, Yves
    et al.
    Montpellier SupAgro, UMR AGAP, Montpellier, France.;Univ Montpellier, CNRS IRD EPHE, UMR ISEM 5554, Montpellier, France.;PSL Res Univ, Ecole Normale Super, CNRS, IBENS,INSERM, Paris, France..
    Sarah, Gautier
    INRA, UMR AGAP, Montpellier, France.;SouthGreen Platform, Montpellier, France..
    Holtz, Yan
    Montpellier SupAgro, UMR AGAP, Montpellier, France..
    Homa, Felix
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab. SouthGreen Platform, Montpellier, France..
    Pointet, Stephanie
    SouthGreen Platform, Montpellier, France.;CIRAD, UMR AGAP, Montpellier, France.;ALCEDIAG CNRS Sys2Diag FRE3690, Biol Complex Syst Modelling & Engn Diag, Montpellier, France..
    Contreras, Sandy
    SouthGreen Platform, Montpellier, France.;GenoScreen, Lille, France..
    Nabholz, Benoit
    Univ Montpellier, CNRS IRD EPHE, UMR ISEM 5554, Montpellier, France..
    Sabot, Francois
    SouthGreen Platform, Montpellier, France.;IRD, UMR DIADE, Montpellier, France..
    Saune, Laure
    INRA, CBGP UMR1062, Montferrier Sur Lez, France..
    Ardisson, Morgane
    INRA, UMR AGAP, Montpellier, France..
    Bacilieri, Roberto
    INRA, UMR AGAP, Montpellier, France..
    Besnard, Guillaume
    Univ Toulouse III, CNRS ENSFEA IRD, UMR EDB 5174, Toulouse, France..
    Berger, Angelique
    CIRAD, UMR AGAP, Montpellier, France..
    Cardi, Celine
    CIRAD, UMR AGAP, Montpellier, France..
    De Bellis, Fabien
    CIRAD, UMR AGAP, Montpellier, France..
    Fouet, Olivier
    CIRAD, UMR AGAP, Montpellier, France..
    Jourda, Cyril
    CIRAD, UMR AGAP, Montpellier, France.;CIRAD, UMR PVBMT, St Pierre, Reunion, France..
    Khadari, Bouchaib
    INRA, UMR AGAP, Montpellier, France..
    Lanaud, Claire
    CIRAD, UMR AGAP, Montpellier, France..
    Leroy, Thierry
    CIRAD, UMR AGAP, Montpellier, France..
    Pot, David
    Sauvage, Christopher
    INRA, GAFL UR1052, Montfavet, France..
    Scarcelli, Nora
    IRD, UMR DIADE, Montpellier, France..
    Tregear, James
    IRD, UMR DIADE, Montpellier, France..
    Vigouroux, Yves
    IRD, UMR DIADE, Montpellier, France..
    Yahiaoui, Nabila
    CIRAD, UMR AGAP, Montpellier, France..
    Ruiz, Manuel
    SouthGreen Platform, Montpellier, France.;CIRAD, UMR AGAP, Montpellier, France..
    Santoni, Sylvain
    INRA, UMR AGAP, Montpellier, France..
    Labouisse, Jean-Pierre
    CIRAD, UMR AGAP, Montpellier, France..
    Pham, Jean-Louis
    IRD, UMR DIADE, Montpellier, France..
    David, Jacques
    Montpellier SupAgro, UMR AGAP, Montpellier, France..
    Glemin, Sylvain
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Univ Montpellier.
    Evolutionary forces affecting synonymous variations in plant genomes2017In: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 13, no 5, e1006799Article in journal (Refereed)
    Abstract [en]

    Base composition is highly variable among and within plant genomes, especially at third codon positions, ranging from GC-poor and homogeneous species to GC-rich and highly heterogeneous ones (particularly Monocots). Consequently, synonymous codon usage is biased in most species, even when base composition is relatively homogeneous. The causes of these variations are still under debate, with three main forces being possibly involved: mutational bias, selection and GC-biased gene conversion (gBGC). So far, both selection and gBGC have been detected in some species but how their relative strength varies among and within species remains unclear. Population genetics approaches allow to jointly estimating the intensity of selection, gBGC and mutational bias. We extended a recently developed method and applied it to a large population genomic dataset based on transcriptome sequencing of 11 angiosperm species spread across the phylogeny. We found that at synonymous positions, base composition is far from mutation-drift equilibrium in most genomes and that gBGC is a widespread and stronger process than selection. gBGC could strongly contribute to base composition variation among plant species, implying that it should be taken into account in plant genome analyses, especially for GC-rich ones.

  • Yang, Fan
    et al.
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.;Univ Toronto, Dept Comp Sci, Toronto, ON, Canada.;Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada..
    Sun, Song
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.;Univ Toronto, Dept Comp Sci, Toronto, ON, Canada.;Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada..
    Tan, Guihong
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada..
    Costanzo, Michael
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada..
    Hill, David E.
    Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA.;Harvard Med Sch, Dept Genet, Boston, MA USA..
    Vidal, Marc
    Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA.;Harvard Med Sch, Dept Genet, Boston, MA USA..
    Andrews, Brenda J.
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada..
    Boone, Charles
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.;Canadian Inst Adv Res, Toronto, ON, Canada..
    Roth, Frederick P.
    Donnelly Ctr, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.;Univ Toronto, Dept Comp Sci, Toronto, ON, Canada.;Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.;Dana Farber Canc Inst, CCSB, Boston, MA 02115 USA.;Canadian Inst Adv Res, Toronto, ON, Canada..
    Identifying pathogenicity of human variants via paralog-based yeast complementation2017In: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 13, no 5, e1006779Article in journal (Refereed)
    Abstract [en]

    To better understand the health implications of personal genomes, we now face a largely unmet challenge to identify functional variants within disease-associated genes. Functional variants can be identified by trans-species complementation, e.g., by failure to rescue a yeast strain bearing a mutation in an orthologous human gene. Although orthologous complementation assays are powerful predictors of pathogenic variation, they are available for only a few percent of human disease genes. Here we systematically examine the question of whether complementation assays based on paralogy relationships can expand the number of human disease genes with functional variant detection assays. We tested over 1,000 paralogous human-yeast gene pairs for complementation, yielding 34 complementation relationships, of which 33 (97%) were novel. We found that paralog-based assays identified disease variants with success on par with that of orthology-based assays. Combining all homology-based assay results, we found that complementation can often identify pathogenic variants outside the homologous sequence region, presumably because of global effects on protein folding or stability. Within our search space, paralogy-based complementation more than doubled the number of human disease genes with a yeast-based complementation assay for disease variation.

  • Restadh, Petter
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    The Ratliff-Rush Operation for Certain Monomial Ideals in K[x, y]2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Tönqvist, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Finding Patterns in Lock-Free Algorithms2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Lock-free algorithms are an approach to concurrent programming wherethreads access shared state without mutual exclusion. Writing correctcomplex lock-free programs can come with great difficulties. The typesystem Capable aims to aid the programmer in writing concurrentsoftware, such as lock-free algorithms. This thesis presents ananalysis of the current state of Capable and how applicable it is tomodern lock-free data structures. It also presents common patternsfound in various lock-free data structures, which can be reused whenwriting new lock-free data structures.

  • Lan, Fangming
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Filtering Redundant Features by Similarity Comparisons2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the field of Biology, exposure to diseases is dependent on several factors which areintricately correlated. Statistical analyses of these diseases often suffer from too manyfactors generated, resulting in complexity of these analyses. In order to solve theseissues, we propose a program that would identify the correlated factors and thenremove some insignificant factors, thus reducing the total number of factors. As aresult, the efficiency of calculation will be improved. The new algorithms detailed hereare based on Apriori and Chi-square tests. They work by reducing the size of theinitial data. Consequently, two algorithms have been suggested and the insignificancefeatures in test dataset efficiently removed as well. It is evident that using reasonablealgorithms can help improve the efficiency and performance in statistical analyses.

  • Ingmar, Linnea
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    Implementation and Evaluation of a Compact-Table Propagator in Gecode2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In constraint programming, which is a programming paradigm for solvingcombinatorial(optimisation) problems, relations among variables are expressed using constraints —one suchuseful constraint is Table, which expresses the possible combinations that thevariables cantake as a set of tuples. All constraints have a propagation algorithm, whose purpose istoimplement the reasoning for a particular constraint. Gecode [7], which is anopen-sourceconstraint-programming solver written in C++ with state-of-the-art performance,currently hastwo propagation algorithms for the Table constraint, and one for a closely relatedconstraintcalled Regular. In this bachelor dissertation, a new propagation algorithm for theTableconstraint, called compact-table, first proposed in [6], is for the first time designedandoptimised for, and implemented and evaluated in Gecode. The implementation isevaluated on alarge variety of benchmarks, and the results indicate that compact-table outperformstheexisting propagators for Table in Gecode, as well as the propagator for the Regularconstraint.These results suggest that compact-table should be included in Gecode.

  • Ekegren, Sanna
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Tierney, Lisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hållbarhetsredovisning: En kvantitativ studie på faktorers påverkan på mängd hållbarhetsredovisning2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Hållbarhet är idag ett högaktuellt ämne och svenska bolag är bland de bättre i världen på att redovisa sitt hållbarhetsarbete. Hållbarhetsredovisning har länge varit frivilligt och det kan vara svårt att se de bakomliggande motiven till bolagens frivilliga redovisning. Om motiven bakom den frivilliga redovisningen är svårbedömda minskar möjligheterna för intressenter att ta välinformerade investeringsbeslut. Genom en kvantitativ undersökning på svenska börsnoterade bolag är syftet med studien att undersöka hur branschtillhörighet, storlek och lönsamhet påverkar mängd hållbarhetsrelaterad information bolaget förmedlar. I den multivariata regressionsanalysen finner vi positiva samband mellan mängd hållbarhetsredovisning och de faktorer som undersökts vilket ligger i linje med tidigare forskning. Det starkaste variabelsambandet är det mellan storlek och mängd hållbarhetsredovisning. Däremot uppmättes inte signifikant samband för variabeln lönsamhet.

  • Riihimäki, Jessica
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Performing internal communication with the help of digital tools: A study of how employees utilize internal communication together with digital tools2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Eriksson, Alexander
    et al.
    Eriksson, Andreas
    Nyström, Ville
    Odelgard, Kajsa
    Pierrou, Clara
    En giftfri konstgräsplan2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    EPDM and R-EPDM granules are used as infill on all of the artificial football fields in Uppsala. The aim of the study was to establish possible health risks related to the infill for players on artificial turf in Uppsala. Furthermore the aim was to investigate the possible ecotoxicological effect on surrounding waterways by the infill material. A comparative analysis concerning health and ecotoxicological effects for these materials was carried out. Eight different granules from the artificial turf in Uppsala was collected and analysed using TGA. The TGA results were modelled in two different scenarios to show possible air concentrations of 100-300 µg/m3 VOC over artificial football fields with EPDM granules. Calculations based on the tolerable daily dose of substances found in the granules were carried out. The conclusions of the study shows that the EPDM granules used today are safe from a health perspective. SBR granules from recycled tires does not constitute to any health risks either. The ecotoxicological risk for surrounding waterways is low. EPDM is less cost and energy efficient compared to SBR from recycled tires. Reduction of granular spill is very important from an environmental and cost point of view, regardless of the choice of material for artificial turf.

  • Nyström, Ville
    et al.
    Odelgard, Kajsa
    Pierrou, Clara
    Eriksson, Andreas
    Eriksson, Alexander
    En giftfri konstgräsplan2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    EPDM and R-EPDM granules are used as infill on all of the artificial football fields in Uppsala. The aim of the study was to establish possible health risks related to the infill for players on artificial turf in Uppsala. Furthermore the aim was to investigate the possible ecotoxicological effect on surrounding waterways by the infill material. A comparative analysis concerning health and ecotoxicological effects for these materials was carried out. Eight different granules from the artificial turf in Uppsala was collected and analysed using TGA. The TGA results were modelled in two different scenarios to show possible air concentrations of 100-300 µg/m3 VOC over artificial football fields with EPDM granules. Calculations based on the tolerable daily dose of substances found in the granules were carried out. The conclusions of the study shows that the EPDM granules used today are safe from a health perspective. SBR granules from recycled tires does not constitute to any health risks either. The ecotoxicological risk for surrounding waterways is low. EPDM is less cost and energy efficient compared to SBR from recycled tires. Reduction of granular spill is very important from an environmental and cost point of view, regardless of the choice of material for artificial turf.

  • Alnebo, Carl
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Von Sydow, Sara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Effektiv repatriering: Outnyttjad eller överflödig resurs?2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Internationella forskare har genom åren försökt få praktiker att inse hur mycket som finns att vinna på en tydlig och effektiv repatrieringsprocess, men få företag världen över verkar ha tagit fasta på råden och problemet med repatriater som inte känner sig uppskattade eller inte får tillräckligt stöd och slutar i bolagen är fortfarande aktuellt. Att undersöka om och hur de verktyg som tagits fram för att effektivisera repatrieringen används i multinationella bolag ger en djupare förståelse för repatrieringsprocessen och hur den nyttjas.

    Studiens syfte är att, genom intervjuer med hemkomna expatriater och ansvariga på personalavdelningen, utforska och beskriva repatrieringsprocessen på Ericsson ur ett organisations- och individperspektiv samt undersöka hur effektiv den processen är. Ericsson använder, trots sitt stora nyttjande av expatriater, ytterst få verktyg för att effektivisera hemkomsten. Studien visar också att det finns en rad verktyg som kan användas för att skapa en smidig och mer effektiv repatriering för både organisation och individ, men att varje företag måste välja ut de som passar verksamheten bäst och satsa på att ge det stöd som tas emot av de anställda.

  • Andersson, Rebecca
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP).
    Marta, Zdravkovic
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, International Science Programme (ISP). Örebro universitet.
    The International Science Programme in Sri Lanka and Thailand: Three decades of research cooperation2017 (ed. 1)Book (Other (popular science, discussion, etc.))
    Abstract [en]

    Developing capacity for research and higher education takes time, especially in resource scarce environments. Equipping laboratories, building human capacity, and establishing research cultures at teaching oriented universities are complex and slow processes. This book focuses on the long-term cooperation with chemistry and physics research groups at universities in Sri Lanka and Thailand, provided by the International Science Programme (ISP) at Uppsala University, Sweden. It traces and gathers experiences from graduated students and other collaborating partners from supported groups. It addresses questions of if, and how, capacity for research and higher education has developed over the decades of ISP support, and the possible effects, efficiency, sustainability and improvements of it.

  • Lindkvist, Marcus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Simulating the Response of the Ocean for a Doubling of Carbon Dioxide in the Atmosphere2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The uptake of carbon in the ocean may change with global warming, which can have significant feedback effects on the climate. To investigate the change, a two box ocean model has been used to simulate the temperature and carbon content in the atmosphere, in a shallow and deep layer of the ocean, when doubling the amount of carbon dioxide in the atmosphere. The results were compared with a low-resolution Earth system model called cGENIE, which is a more complex model. The two box ocean model showed an increase of temperature in the ocean by 1.2°C. A similar response was simulated in cGENIE where the shallow ocean (0-80 meters depth) increased by 0.22°C. The deep ocean (down to 3600 meters) warmed by 0.48°C. The carbon content followed the same behavior in both models. Carbon dioxide in the atmosphere was absorbed by the ocean after the initial doubling. As the ocean absorbed carbon dioxide the radiative forcing decreased again, reducing the warming effect. The two box model is a conceptual model of the carbon cycle in the ocean that can provide a useful illustration of the key balance of carbon in the climate system, despite the many simplifications.

  • Silversparf, Agneta
    Silbonah Sámesijdda.
    Samisk släktforskning som motstånd och verktyg: mot etnisk rensning och för att återta vårt minne, vår historia och kultur2017In: Uppsala mitt i Sápmi – Sábme – Saepmie II: En supradisciplinär antologi härrörande från vårsymposium organiserat av Uppsam –Föreningen for samiskrelaterad forskning i Uppsala, Uppsala universitet, 28–29 april 2014 / [ed] May-Britt Öhman, Cecilia Hedlund, Gunilla Larsson, Uppsala: Uppsam - föreningen för samiskrelaterad forskning i Uppsala , 2017, 16-24 p.Chapter in book (Other academic)
    Abstract [en]

    This article accounts for the history of Swedish state regulations against the Sami people in terms of numbers, heritage and decision-making. For instance, currently it is not the Sami People as People that are considered to be Sami. The current official number of Sami often referred to in official documents are based on Sami working in the profession of reindeer herding. The actual number of Sami persons is hidden by State-based regulations and categorizations. This is due to a century long racist policy called “Lap should be Lap” aiming at reducing the official number of Sami individuals, and thereby erasing the Sami cultures. The article discusses the work by Sami genealogist to counter this categorization. By doing the genealogy work and publishing it four times per year to the members of the Sami association Silbonah Sámesijdda, the genealogy work becomes both an act of resistance as well as an act of reclaiming Sami history and memory. The author also shares memories of her own family history, and how this is linked with her work to do genealogy and reclaim heritage of the Sami in general. Lastly, some reflections regarding the future of Sami genealogy are presented.

    The work with this article has partly been financed through the research project "Rivers, Resistance, Resilience: Sustainable Futures in Sápmi" led by Dr. May-Britt Öhman, and financed by Formas, 2012-2015.

  • Fichtel, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Inkubatorers logik: en studie av svenska inkubatorers institutionella logik2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Business incubators have become an integrated part of innovation systems worldwide, designed to support innovative entrepreneurship and regional development. However, empirical research on incubated firms show mixed results on innovation and growth. In this paper, 18 Swedish incubators, top-ranked and funded by government innovation programs, are studied through the lens of the institutional logics perspective. Multiple conflicts in state and market logics are highlighted and discussed, as well as implications for new venture creation and future research on business incubators as influential institutional actors.

  • Michaelsdotter, Rebecka
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Öhlund, Sanna
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Ett traineeprogram (o)möjligt inom byggbranschen: En fallstudie av Veidekke och erfarenheter från traineer inom Skanska och Scania2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Ahlgren Peters, Adam
    et al.
    Söderholm, Robin
    Wahlmark, Rickard
    Analog gitarrförstärkare: med rörliknande egenskaper2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Lindqvist, Elias
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Olsson, Christoffer
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Vikten av hållbart byggande: En studie över användandet av livscykelanalyser för bättre miljöval inom byggbranschen2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Purpose:

    To use theory about organization, stakeholders, knowledge management and powerstructures to analyze the challenges regarding life-cycle assessments in theconstruction industry in Sweden. The study aims to provide a deeper understandingof why the challenges exists and how companies can work to manage them.

    Research questions:

    How are life-cycle assessments used within the construction industry today?- What challenges exists in the use of life-cycle assessments today?- What stakeholders affect the use of life-cycle assessments today?- How does the organisation within construction companies affect the use oflifecycle assessment?- How are life-cycle assessments affected by the different degree of knowledge thestakeholders have?

    Methodology:

    This is a study of inductive character and is performed as a case study at a largeconstruction company. The study starts with an initial literature study and identifiesrelevant theory to answer the research questions. Then the gathering of empiricaldata is made by industry and government reports, interviews and a focus group.The findings were then analysed and compared to the theory.

    Results:

    The results show that the client is the stakeholder with the highest influence of theuse of life-cycle assessments. However, this stakeholder category was identified tohave insufficient knowledge about life-cycle assessments and the benefits of it.There is also no accepted standard for comparison between different actors.Therefore, demand remain low but the study show that the knowledge and demandfrom clients are growing and will do so in the future. The organisation need to workcloser to the suppliers and external contractors to efficiently conduct life-cycleassessments. This could lead to competitive advantage as the demand for theservice grows.

  • Barregren, Simon
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Spjutets plats i kultur och tro: En undersökning av dekorerade spjut i Birkas kammargravar2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The Viking Age town Birka has since long been a central part of archaeological studies and excavations in Sweden. It has brought much light and information about the people living there from the late 8th century to the late 10th century. The purpose of this thesis is to explore the decorated spears found in a selected number of Birka's chamber graves to see if any visual traces of religious expressions are present. The spears and their context will then be put into contrast with the clear patterns of the worship of Odin in Birka's Garrison area and religious studies from pre-Christian Scandinavia. This is done in the hopes of shedding some light on the spear’s relevance in the Viking Age's culture and religious contexts.

  • Inkapööl, Julia
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Framtagande av platsspecifik grundvattenmodell samt modellering av klorerade lösningsmedels spridning i grundvatten kring industritomt: – Utvärdering av nuvarande samt framtida föroreningssituation2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    One of the Government's environmental quality objectives is to achieve a poison free environment, meaning that the presence of anthropogenic substances in the environment should not pose a threat to human health or biodiversity. Such a substance is chlorinated aliphatic hydrocarbons which have been used historically in dry cleaning and as degreasing agents within industrial processes. In recent years, negative effects on human health have been found since exposure to chlorinated solvents is associated with toxic and carcinogen effects, which has resulted in constrictions against such substances today.At the former Whirlpool industry in Himmelstalund, in Norrköping, the chlorinated solvents perchlorethylene (PCE) and trichlorethylene (TCE) have been used historically during production. Concentrations of PCE and TCE and their degradation products cis–1,2–dichloroethylene (cis–1,2–DCE) and vinyl chloride (VC) have been detected in groundwater at the site. This Master´s thesis aimed to develop a site–specific groundwater flow model and a mass transport model to simulate the spread of these compounds through the saturated zone after 10, 30 and 75 years. The groundwater model was developed in MODFLOW and calibrated based on known hydrological and geological conditions after which a sensitivity analysis was performed regarding hydraulic conductivity and effective porosity. It was found that the flow model generated flows which corresponded to measured ones when hydraulic conductivity was employed within the range 10–5–10–2 m/s and effective porosity in the range 5–25%.It was found that PCE, TCE and cis–1,2–DCE did not reach the surface water recipient Motala river within 75 years, the compounds traveled 500 meters west of the source zone as furthest. However, VC reached Motala river within ten years, depending on which initial concentration were applied. The plume of VC remained in the aquifer after 75 years containing concentrations exceeding the guideline values in groundwater. This is considered severe since chlorinated solvents are toxic and cancerogenic to humans.A sensitivity analysis with regard to adsorption and reaction parameters was performed where it was found that the adsorption greatly affected the spread of the plumes and was more influencing than how the reaction parameters were applied. When maximum adsorption was employed, PCE, TCE and cis–1,2–DCE remained adjacent to the source zone while VC moved about 500 meters. It was seen that the mobile properties of the compounds were considerably larger for all components when minimal adsorption was applied. Hydraulic conductivity had a major impact on transport times where higher hydraulic conductivity resulted in faster transportation through the aquifer.As the spread through the aquifer was largely affected by which parameters were chosen, it was assessed relevant to measure hydraulic conductivity, adsorption constants and measure groundwater levels in more points spread in the model area in order to improve the reliability of the mass transport model.

  • Dumanski, Jan P.
    et al.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Rasi, Chiara
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Björklund, Peyman
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Experimental Surgery.
    Davies, Hanna
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Ali, Abir S
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine oncology.
    Grönberg, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine oncology.
    Welin, Staffan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine oncology.
    Sorbye, Halfdan
    Grønbæk, Henning
    Cunningham, Janet L
    Forsberg, Lars A.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Lind, Lars
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Ingelsson, Erik
    Stålberg, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    Hellman, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors.2017In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 24, no 8, 427-443 p.Article in journal (Refereed)
    Abstract [en]

    The genetics behind predisposition to small intestinal neuroendocrine tumors (SI-NETs) is largely unknown, but there is growing awareness of a familial form of the disease. We aimed to identify germline mutations involved in the carcinogenesis of SI-NETs. The strategy included next-generation sequencing of exome- and/or whole-genome of blood DNA, and in selected cases, tumor DNA, from 24 patients from 15 families with the history of SI-NETs. We identified seven candidate mutations in six genes that were further studied using 215 sporadic SI-NET patients. The result was compared with the frequency of the candidate mutations in three control cohorts with a total of 35,688 subjects. A heterozygous variant causing an amino acid substitution p.(Gly396Asp) in the MutY DNA glycosylase gene (MUTYH) was significantly enriched in SI-NET patients (minor allele frequencies 0.013 and 0.003 for patients and controls respectively) and resulted in odds ratio of 5.09 (95% confidence interval 1.56-14.74; P value = 0.0038). We also found a statistically significant difference in age at diagnosis between familial and sporadic SI-NETs. MUTYH is involved in the protection of DNA from mutations caused by oxidative stress. The inactivation of this gene leads to specific increase of G:C- > T:A transversions in DNA sequence and has been shown to cause various cancers in humans and experimental animals. Our results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 gene) might be involved in driving the tumorigenesis leading to familial and sporadic SI-NETs.

  • Löfgren, Max
    et al.
    Geirsson, Gunnlaugur
    Huotila, Kristian
    Konstruktion av effektpedaler för elgitarrer2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Maleka, Aglaia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Enblad, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Sjörs, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Lindqvist, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Ullenhag, Gustav
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Treatment of metastatic malignant melanoma with vemurafenib during pregnancy2013In: Journal of Clinical Oncology, ISSN 0732-183X, Vol. 31, no 11, e192-e193 p.Article in journal (Refereed)
  • Eggefalk, Jennifer
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Skärpt straff vid återfall - En granskning av BrB 29:4 och dess förankring i destraffrättsliga teorierna2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Landau, Robin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Tiderna förändras: En statistisk studie om den svenska arbetstidsutvecklingen 1960-20142017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I uppsatsen studeras den svenska arbetstidens utveckling mellan 1960 och 2014, en tidsperiodsom enligt Schön ungefär motsvarar en strukturcykel. Med hjälp av regressionsanalysundersöks förhållandet mellan den svenska årsarbetstiden och variablerna BNP,arbetsproduktivitet, arbetslöshet och löneandel, för att se vilka faktorer som i högst gradsamverkar med förändrad arbetstid. Syftet är att se om det finns statistiskt stöd förmaktresursteorin och/eller synen att förkortad arbetstid är en konsekvens av ekonomiskutveckling. Resultatet visar att det inte finns stöd för att svensk arbetstid påverkats avmaktresursfördelningar, samtidigt som det höga statistiska sambandet mellan årsarbetstid ochBNP och arbetsproduktivitet indikerar att arbetstid och ekonomisk utveckling samverkar.

  • Wang, Shunguo
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics. Scripps Institution of Oceanography, UC San Diego.
    Joint inversion and integration of multiple geophysical data for improved models of near-surface structures2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Geophysical methods are non-invasive and allow an effective way of understanding subsurface structures and their physical properties. One of the main challenges is the often non-uniqueness of the geophysical models and that several different models can explain a dataset to an agreeable fit. Moreover, noise and limitations in resolution, which are inherent to field data, are additional obstacles for obtaining a true physical property model of the subsurface. Facing all these challenges, geophysicists have dedicated their efforts for decades to recover models that represent, as close as possible, the true subsurface. Joint inversion and integration of multiple geophysical data are two main approaches that I studied to better resolve subsurface structures. I further used these approaches, together with new software and hardware implementations for data acquisition and inversion, for near-surface applications. 

    In this thesis, radio-magnetotelluric (RMT), boat-towed RMT, boat-towed controlled source MT (CSMT), electrical resistivity tomography (ERT), and first-arrival traveltime tomography are jointly used for quick clay investigations and fracture zone delineation under shallow water-bodies. The joint approach, as compared with any individual method, shows a better ability to both resolve the geological targets and to assist in understanding the subsurface geology that hosts these targets. For examples: by performing the joint inversion of lake-floor ERT and boat-towed RMT data, a fracture zone is better delineated with greater details compared with single inversion; by employing boat-towed CSMT measurements and jointly inverting with boat-towed RMT data, the subsurface structures, especially at greater depth, are better resolved than by inverting each dataset alone.

    During my PhD studies, two types of new implementations were employed. (1) Boat-towed data acquisition system was implemented to expand the RMT and CSMT method from land to shallow-water applications. This is significant since many large-scale underground infrastructures are likely to cross these water zones (for example multi-lane train or bypass tunnels, such as the Stockholm bypass). (2) The modification of a well-structured code EMILIA allows joint inversion of boat-towed RMT and lake-floor ERT datasets, and the modification of another well-structured code MARE2DEM can accurately model high frequency CSMT data and handle joint inversion of boat-towed RMT and boat-towed CSMT datasets. Thus, the code modification as another type of new implementation guarantees the success of near-surface applications using the boat-towed RMT and CSMT data acquisition systems.

    Studies conducted during my PhD work, included under the SEG-GWB (the Society of Exploration Geophysicists - Geoscientists Without Borders) program and the TRUST (TRansparent Underground STructure) umbrella project, are useful for near-surface applications including, for examples, engineering purposes such as planning of underground infrastructures, site characterization in connection with energy or waste storage, and geohazard investigations.

    List of papers
    1. Geophysical characterization of areas prone to quick-clay landslides using radio-magnetotelluric and seismic methods
    Open this publication in new window or tab >>Geophysical characterization of areas prone to quick-clay landslides using radio-magnetotelluric and seismic methods
    2016 (English)In: Tectonophysics, ISSN 0040-1951, E-ISSN 1879-3266, Vol. 677, 248-260 p.Article in journal (Refereed) Published
    Abstract [en]

    Landslides attributed to quick clays have not only considerable influences on surface geomorphology, they have caused delays in transportation systems, environmental problems and human fatalities, especially in Scandinavia and North America. If the subsurface distributions of quick clays are known, potential damages can be mitigated and the triggers of landslides can better be studied and understood. For this purpose, new radio-magnetotelluric (RMT) and seismic data were acquired in an area near the Gota River in southwest Sweden that contains quick clays and associated landslides. High-resolution data along 4 new lines, in total 3.8 km long, were acquired and merged with earlier acquired data from the site. Velocity and resistivity models derived from first breaks and RMT data were used to delineate subsurface geology, in particular the bedrock surface and coarse-grained materials that overlay the bedrock. The latter often are found underlying quick clays at the site. Comparably high resistivity and sometimes high-velocity regions within marine clays are attributed to a combination of leached salt from marine clays or potential quick clays and coarse-grained materials. The resistivity and tomographic velocity models suggest a much larger role of the coarse-grained materials at the site than previously thought, but they also suggest two different scenarios for triggering quick-clay landslides at the site. These scenarios are related to the erosion of the riverbank, increased pore-pressure and surface topography when close to the river and human activity when away from the river and where bowl-shaped bedrock surrounds the sediments.

    Keyword
    Quick clay, Landslide, Radio-magnetotelluric, Seismic, Tomography, Coarse grain
    National Category
    Geophysics
    Identifiers
    urn:nbn:se:uu:diva-299505 (URN)10.1016/j.tecto.2016.04.020 (DOI)000377311700018 ()
    Funder
    Swedish Research Council Formas, 25220121907
    Available from: 2016-07-22 Created: 2016-07-22 Last updated: 2017-08-03Bibliographically approved
    2. Joint inversion of lake-floor electrical resistivity tomography and boat-towed radio-magnetotelluric data illustrated on synthetic data and an application from the Äspö Hard Rock Laboratory site, Sweden
    Open this publication in new window or tab >>Joint inversion of lake-floor electrical resistivity tomography and boat-towed radio-magnetotelluric data illustrated on synthetic data and an application from the Äspö Hard Rock Laboratory site, Sweden
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Geophysics
    Identifiers
    urn:nbn:se:uu:diva-327094 (URN)
    Available from: 2017-08-02 Created: 2017-08-02 Last updated: 2017-08-04Bibliographically approved
    3. Using boat-towed controlled source radio-magnetotellurics to resolve fracture zones at Äspö Hard Rock Laboratory site, Sweden
    Open this publication in new window or tab >>Using boat-towed controlled source radio-magnetotellurics to resolve fracture zones at Äspö Hard Rock Laboratory site, Sweden
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Geophysics
    Identifiers
    urn:nbn:se:uu:diva-327095 (URN)
    Available from: 2017-08-02 Created: 2017-08-02 Last updated: 2017-08-03Bibliographically approved
  • Pavliuk, Mariia V.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Fernandes, Arthur B.
    Abdellah, Mohamed
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Fernandes, Daniel L. A.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Machado, Caroline O.
    Rocha, Igor
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Hattori, Yocefu
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Paun, Cristina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Bastos, Erick L.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Sá, Jacinto
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Nano-hybrid plasmonic photocatalyst for hydrogen production at 20% efficiency2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, no 8670Article in journal (Refereed)
    Abstract [en]

    The efficient conversion of light energy into chemical energy is key for sustainable human development. Several photocatalytic systems based on photovoltaic electrolysis have been used to produce hydrogen via water reduction. However, in such devices, light harvesting and proton reduction are carried separately, showing quantum efficiency of about 10–12%. Here, we report a nano-hybrid photocatalytic assembly that enables concomitant reductive hydrogen production and pollutant oxidation with solar-to-fuel efficiencies up to 20%. The modular architecture of this plasmonic material allows the fine-tuning of its photocatalytic properties by simple manipulation of a reduced number of basic components.

  • Granjon, Valentin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Benedic, Romain
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Instagram's Social Media Influencers: A study of Online Popularity From Source Credibility to Brand Attitude2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Social Media Influencers (SMIs) and their sponsored posts on the Social Media represent a growing part of tomorrow’s digital marketing landscape. Marketers hire them to recommend their products to their large audiences through friendly and engaging social media posts. To please marketers, increasing and maintaining their audience size is of the utmost importance. Consequently, number of followers, likes, and comments have become the metrics of SMIs success. However, recent contradictory publications of business magazines and academic research raised the question of SMIs’ online popularity, credibility, and their efficiency as brand endorsers. Hence, an online-based survey experiment based examined the audience’s attitude of SMI credibility across three different level of online popularity using Ohanian’s (1990) source credibility model. Further, the relationship between SMI credibility and brand attitude, and the mediating effect of attitude toward sponsored post were investigated using a research model adapted from Attitude toward advertising models. The findings revealed that the more an SMI is popular, the more he is perceived as a credible brand advocate, and SMI credibility was found to positively and directly influences brand attitude. Semi-structured interviews strengthened the discussion of the quantitative results. Theoretical and managerial contributions of the study are presented and suggestions for future research ensue.

  • Galand, M.
    et al.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Heritier, K. L.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Odelstad, Elias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Henri, P.
    Univ Orleans, CNRS, LPC2E, 3A,Ave Rech Sci, F-45071 Orleans 2, France..
    Broiles, T. W.
    Southwest Res Inst, PO Drawer 28510, San Antonio, TX 78228 USA..
    Allen, A. J.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Altwegg, K.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Beth, A.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Burch, J. L.
    Southwest Res Inst, PO Drawer 28510, San Antonio, TX 78228 USA..
    Carr, C. M.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Cupido, E.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Eriksson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Glassmeier, K. -H
    Johansson, Fredrik L.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Lebreton, J. -P
    Mandt, K. E.
    Southwest Res Inst, PO Drawer 28510, San Antonio, TX 78228 USA..
    Nilsson, H.
    Swedish Inst Space Phys, POB 812, SE-98128 Kiruna, Sweden..
    Richter, I.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Rubin, M.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Sagnieres, L. B. M.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Schwartz, S. J.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England..
    Semon, T.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Tzou, C. -Y
    Vallieres, X.
    Univ Orleans, CNRS, LPC2E, 3A,Ave Rech Sci, F-45071 Orleans 2, France..
    Vigren, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Wurz, P.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Ionospheric plasma of comet 67P probed by Rosetta at 3 au from the Sun2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S331-S351 p.Article in journal (Refereed)
    Abstract [en]

    We propose to identify the main sources of ionization of the plasma in the coma of comet 67P/Churyumov-Gerasimenko at different locations in the coma and to quantify their relative importance, for the first time, for close cometocentric distances (< 20 km) and large heliocentric distances (> 3 au). The ionospheric model proposed is used as an organizing element of a multi-instrument data set from the Rosetta Plasma Consortium (RPC) plasma and particle sensors, from the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis and from the Microwave Instrument on the Rosetta Orbiter, all on board the ESA/Rosetta spacecraft. The calculated ionospheric density driven by Rosetta observations is compared to the RPC-Langmuir Probe and RPC-Mutual Impedance Probe electron density. The main cometary plasma sources identified are photoionization of solar extreme ultraviolet (EUV) radiation and energetic electron-impact ionization. Over the northern, summer hemisphere, the solar EUV radiation is found to drive the electron density - with occasional periods when energetic electrons are also significant. Over the southern, winter hemisphere, photoionization alone cannot explain the observed electron density, which reaches sometimes higher values than over the summer hemisphere; electron-impact ionization has to be taken into account. The bulk of the electron population is warm with temperature of the order of 7-10 eV. For increased neutral densities, we show evidence of partial energy degradation of the hot electron energy tail and cooling of the full electron population.

  • Fuselier, S. A.
    et al.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA.;Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA..
    Altwegg, K.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Balsiger, H.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Berthelier, J. J.
    LATMOS, 4 Ave Neptune, F-94100 St Maur, France..
    Beth, A.
    Imperial Coll London, Dept Phys, Space & Atmospher Phys Grp, Prince Consort Rd, London SW7 2AZ, England..
    Bieler, A.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland.;Univ Michigan, Dept Atmospher Ocean & Space Sci, 2455 Hayward, Ann Arbor, MI 48109 USA..
    Briois, C.
    Univ Orleans, CNRS, Lab Phys & Chim Environm & Espace LPC2E, UMR 6115, F-45071 Orleans, France..
    Broiles, T. W.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA..
    Burch, J. L.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA..
    Calmonte, U.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Cessateur, G.
    Belgian Inst Space Aeron BIRA IASB, Ringlaan 3, B-1180 Brussels, Belgium..
    Combi, M.
    Imperial Coll London, Dept Phys, Space & Atmospher Phys Grp, Prince Consort Rd, London SW7 2AZ, England..
    De Keyser, J.
    Belgian Inst Space Aeron BIRA IASB, Ringlaan 3, B-1180 Brussels, Belgium..
    Fiethe, B.
    TU Braunschweig, Inst Comp & Network Engn IDA, Hans Sommer Str 66, D-38106 Braunschweig, Germany..
    Galand, M.
    Imperial Coll London, Dept Phys, Space & Atmospher Phys Grp, Prince Consort Rd, London SW7 2AZ, England..
    Gasc, S.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Gombosi, T. I.
    Univ Michigan, Dept Atmospher Ocean & Space Sci, 2455 Hayward, Ann Arbor, MI 48109 USA..
    Gunell, H.
    Belgian Inst Space Aeron BIRA IASB, Ringlaan 3, B-1180 Brussels, Belgium..
    Hansen, K. C.
    Univ Michigan, Dept Atmospher Ocean & Space Sci, 2455 Hayward, Ann Arbor, MI 48109 USA..
    Hassig, M.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA..
    Heritier, K. L.
    Imperial Coll London, Dept Phys, Space & Atmospher Phys Grp, Prince Consort Rd, London SW7 2AZ, England..
    Korth, A.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Le Roy, L.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Luspay-Kuti, A.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA..
    Mall, U.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Mandt, K. E.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA.;Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA..
    Petrinec, S. M.
    Lockheed Martin Adv Technol Ctr, Palo Alto, CA 94304 USA..
    Reme, H.
    Univ Toulouse, UPS OMP, IRAP, F-31400 Toulouse, France.;CNRS, IRAP, 9 Ave Colonel Roche,BP 44346, F-31028 Toulouse 4, France..
    Rinaldi, M.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA..
    Rubin, M.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Semon, T.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Trattner, K. J.
    Univ Colorado, Lab Atmospher & Space Phys, Boulder, CO 80303 USA..
    Tzou, C. -Y
    Vigren, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Waite, J. H.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA.;Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA..
    Wurz, P.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Ion chemistry in the coma of comet 67P near perihelion2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S67-S77 p.Article in journal (Refereed)
    Abstract [en]

    The coma and the comet-solar wind interaction of comet 67P/Churyumov-Gerasimenko changed dramatically from the initial Rosetta spacecraft encounter in 2014 August through perihelion in 2015 August. Just before equinox (at 1.6 au from the Sun), the solar wind signal disappeared and two regions of different cometary ion characteristics were observed. These 'outer' and 'inner' regions have cometary ion characteristics similar to outside and inside the ion pileup region observed during the Giotto approach to comet 1P/Halley. Rosetta/Double-Focusing Mass Spectrometer ion mass spectrometer observations are used here to investigate the H3O+/H2O+ ratio in the outer and inner regions at 67P/Churyumov-Gerasimenko. The H3O+/H2O+ ratio and the H3O+ signal are observed to increase in the transition from the outer to the inner region and the H3O+ signal appears to be weakly correlated with cometary ion energy. These ion composition changes are similar to the ones observed during the 1P/Halley flyby. Modelling is used to determine the importance of neutral composition and transport of neutrals and ions away from the nucleus. This modelling demonstrates that changes in the H3O+/H2O+ ratio appear to be driven largely by transport properties and only weakly by neutral composition in the coma.

  • Goetz, C.
    et al.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Koenders, C.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Hansen, K. C.
    Univ Michigan, Dept Atmospher Ocean & Space Sci, 2455 Hayward St, Ann Arbor, MI 48109 USA..
    Burch, J.
    Southwest Res Inst, PO Drawer 28510, San Antonio, TX 78228 USA..
    Carr, C.
    Imperial Coll London, Space & Atmospher Phys Grp, Exhibit Rd, London SW7 2AZ, England..
    Eriksson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Fruehauff, D.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Guettler, C.
    Max Planck Inst Sonnensyst Forschung, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Henri, P.
    Univ Orleans, CNRS, UMR 7328, Lab Phys & Chim Environm & Espace, F-45100 Orleans, France..
    Nilsson, H.
    Swedish Inst Space Phys, POB 812, SE-98128 Kiruna, Sweden..
    Richter, I.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Rubin, M.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Sierks, H.
    Max Planck Inst Sonnensyst Forschung, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Tsurutani, B.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Volwerk, M.
    Austrian Acad Sci, Inst Weltraumforsch, Schmiedlstr 6, A-8042 Graz, Austria..
    Glassmeier, K. H.
    TU Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany.;Max Planck Inst Sonnensyst Forschung, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Structure and evolution of the diamagnetic cavity at comet 67P/Churyumov-Gerasimenko2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S459-S467 p.Article in journal (Refereed)
    Abstract [en]

    The long duration of the Rosetta mission allows us to study the evolution of the diamagnetic cavity at comet 67P/Churyumov-Gerasimenko in detail. From 2015 April to 2016 February 665 intervals could be identified where Rosetta was located in a zero-magnetic-field region. We study the temporal and spatial distribution of this cavity and its boundary and conclude that the cavity properties depend on the long-term trend of the outgassing rate, but do not respond to transient events at the spacecraft location, such as outbursts or high neutral densities. Using an empirical model of the outgassing rate, we find a functional relationship between the outgassing rate and the distance of the cavity to the nucleus. There is also no indication that this unexpectedly large distance is related to unusual solar wind conditions. Because the deduced shape of the cavity boundary is roughly elliptical on small scales and the distances of the boundary from the nucleus are much larger than expected we conclude that the events observed by Rosetta are due to a moving instability of the cavity boundary itself.

  • Gicquel, A.
    et al.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Vincent, J. -B
    Agarwal, J.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    A'Hearn, M. F.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Bertini, I.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy..
    Bodewits, D.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Sierks, H.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Li, Z. -Y
    Barbieri, C.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Lamy, P. L.
    Aix Marseille Univ, Lab Astrophys Marseille, UMR 7326, F-13388 Marseille, France..
    Rodrigo, R.
    ESAC, European Space Agcy, CSIC, Ctr Astrobiol,INTA, POB 78, E-28691 Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Koschny, D.
    European Space Agcy, Res & Sci Support Dept, NL-2201 AZ Noordwijk, Netherlands..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland.
    Keller, H. U.
    TU Braunschweig, Inst Geophys & Extraterr Phys, D-38106 Braunschweig, Germany..
    Barucci, M. A.
    Univ Paris Diderot, UPMC Univ Paris 06, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon Pricipal, France..
    Bertaux, J. -L
    Besse, S.
    European Space Agcy, Res & Sci Support Dept, NL-2201 AZ Noordwijk, Netherlands..
    Cremonese, G.
    INAF Osservatorio Astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Da Deppo, V.
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Debei, S.
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    Deller, J.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    De Cecco, M.
    Univ Trento, Via Sommarive 9, I-38123 Trento, Italy..
    Frattin, E.
    INAF Osservatorio Astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    El-Maarry, M. R.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Fornasier, S.
    Univ Paris Diderot, UPMC Univ Paris 06, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon Pricipal, France..
    Fulle, M.
    Osserv Astron Trieste, INAF, Via Tiepolo 11, I-34143 Trieste, Italy..
    Groussin, O.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France..
    Gutierrez, P. J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Gutierrez-Marquez, P.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Guettler, C.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hoefner, S.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany.;TU Braunschweig, Inst Geophys & Extraterr Phys, D-38106 Braunschweig, Germany..
    Hofmann, M.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hu, X.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hviid, S. F.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Ip, W. -H
    Jorda, L.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France..
    Knollenberg, J.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kovacs, G.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany.;Budapest Univ Technol & Econ, Dept Mechatron Opt & Engn Informat, Muegyet Rkp 3, H-1111 Budapest, Hungary..
    Kramm, J. -R
    Kuehrt, E.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kueppers, M.
    ESAC, ESA, POB 78, E-28691 Villanueva De La Canada, Spain..
    Lara, L. M.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Lazzarin, M.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Lopez Moreno, J. J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Lowry, S.
    Univ Kent, Sch Phys Sci, Ctr Astrophys & Planetary Sci, Canterbury CT2 7NH, Kent, England..
    Marzari, F.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Masoumzadeh, N.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Massironi, M.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy..
    Moreno, F.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Mottola, S.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Naletto, G.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy.;CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy.;Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Oklay, N.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Pajola, M.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giuseppe Colom, Via Venezia 15, I-35131 Padua, Italy..
    Pommerol, A.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Preusker, F.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Scholten, F.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Shi, X.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Thomas, N.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Toth, I.
    Aix Marseille Univ, Lab Astrophys Marseille, UMR 7326, F-13388 Marseille, France.;Observ Hungarian Acad Sci, POB 67, H-1525 Budapest, Hungary..
    Tubiana, C.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Sublimation of icy aggregates in the coma of comet 67P/Churyumov-Gerasimenko detected with the OSIRIS cameras on board Rosetta2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S57-S66 p.Article in journal (Refereed)
    Abstract [en]

    Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov-Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance R-h = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness as a function of the distance of the jet is much steeper than the background coma, which is a first indication of sublimation. We adapted a model of sublimation of icy aggregates and studied the effect as a function of the physical properties of the aggregates (composition and size). The major finding of this paper was that through the sublimation of the aggregates of dirty grains (radius a between 5 and 50 mu m) we were able to completely reproduce the radial brightness profile of a jet beyond 4 km from the nucleus. To reproduce the data, we needed to inject a number of aggregates between 8.5 x 10(13) and 8.5 x 10(10) for a = 5 and 50 mu m, respectively, or an initial mass of H2O ice around 22 kg.

  • Lee, Jui-Chi
    et al.
    Natl Cent Univ, Dept Earth Sci, 300 Chung Rd, Chungli 32054, Taiwan..
    Massironi, Matteo
    Univ Padua, Dept Geosci, Via G Gradenigo 6, I-35131 Padua, Italy.;Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Ip, Wing-Huen
    Natl Cent Univ, Inst Astron, 300 Chung Da Rd, Chungli 32054, Taiwan.;Natl Cent Univ, Inst Space Sci, 300 Chung Da Rd, Chungli 32054, Taiwan.;Macau Univ Sci & Technol, Space Sci Inst, Ave Wai Long, Taipa, Macao, Peoples R China..
    Giacomini, Lorenza
    Univ Padua, Dept Geosci, Via G Gradenigo 6, I-35131 Padua, Italy..
    Ferrari, Sabrina
    Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Penasa, Luca
    Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    El-Maarry, Mohamed Ramy
    Univ Bern, Phys Inst, CH-3012 Bern, Switzerland..
    Pajola, Maurizio
    Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy.;NASA, Ames Res Ctr, Moffett Field, CA 94035 USA..
    Lai, Ian-Lin
    Natl Cent Univ, Inst Space Sci, 300 Chung Da Rd, Chungli 32054, Taiwan..
    Lin, Zhong-Yi
    Natl Cent Univ, Inst Astron, 300 Chung Da Rd, Chungli 32054, Taiwan..
    Ferri, Francesca
    Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Sierks, Holger
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Barbieri, Cesare
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Lamy, Philippe
    CNRS, Lab Astrophys Marseille, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France.;Aix Marseille Univ, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France..
    Rodrigo, Rafael
    CSIC, INTA, Ctr Astrobiol, E-28850 Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Koschny, Detlef
    Sci Support Off, European Space Res & Technol Ctr ESA, Keplerlaan 1,Postbus 299, NL-2201AZ Noordwijk ZH, Netherlands..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland.
    Keller, Horst Uwe
    Tech Univ Carolo Wilhelmina Braunschweig, IGEP, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Agarwal, Jessica
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    A'Hearn, Michael F.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany.;Univ Maryland, Dept Astron, College Pk, MD 20742 USA.;Akad Wissensch Gottingen Geschaftsstelle, Theaterstr 7, D-37073 Gottingen, Niedersachsen, Germany..
    Barucci, Maria Antonella
    Univ Paris Diderot, Univ Pierre & Marie Curie, CNRS, LESIA,Observatoire Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Bertaux, Jean-Loup
    Univ Paris Diderot, Univ Pierre & Marie Curie, CNRS, LESIA,Observatoire Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Bertini, Ivano
    Univ Padua, CISAS, Ctr Studies & Activ Space G Colombo, Via Venezia 15, I-35131 Padua, Italy..
    Cremonese, Gabriele
    Osserv Astron Padova, INAF, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Da Deppo, Vania
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Debei, Stefano
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    De Cecco, Mariolino
    Univ Trent, Via Mesiano 77, I-38100 Trento, Italy..
    Deller, Jakob
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Fornasier, Sonia
    Univ Paris Diderot, Univ Pierre & Marie Curie, CNRS, LESIA,Observatoire Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Fulle, Marco
    Osserv Astron Trieste, INAF, Via Tiepolo 11, I-34014 Trieste, Italy..
    Groussin, Olivier
    CNRS, Lab Astrophys Marseille, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France.;Aix Marseille Univ, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France..
    Gutierrez, Pedro J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Guettler, Carsten
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hofmann, Marc
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hviid, Stubbe F.
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany.;Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany..
    Jorda, Laurent
    CNRS, Lab Astrophys Marseille, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France.;Aix Marseille Univ, 38 Rue Frederic Joliot Curie, F-13388 Marseille 13, France..
    Knollenberg, Joerg
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kovacs, Gabor
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Kramm, J. -Rainer
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Kuehrt, Ekkehard
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kuppers, Michael
    European Space Astron Ctr ESA, Operat Dept, POB 78, E-28691 Madrid, Spain..
    Lara, Luisa M.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Lazzarin, Monica
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Marzari, Francesco
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Lopez Moreno, Jose J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Naletto, Giampiero
    Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Oklay, Nilda
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Shi, Xian
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Thomas, Nicolas
    Natl Cent Univ, Inst Astron, 300 Chung Da Rd, Chungli 32054, Taiwan..
    Tubiana, Cecilia
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Vincent, Jean-Baptiste
    Max Planck Inst Sonnensyst Forsch, Justus Von Liebig Weg 3, D-37077 Gottingen, Germany..
    Geomorphological mapping of comet 67P/Churyumov-Gerasimenko's Southern hemisphere2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S573-S592 p.Article in journal (Refereed)
    Abstract [en]

    In 2015 May, the Southern hemisphere of comet 67P/Churyumov-Gerasimenko became visible by the OSIRIS cameras on-board the Rosetta spacecraft. The resolution was high enough to carry out a detailed analysis of the surface morphology, which is quite different from the Northern hemisphere. Previous works show that fine particle deposits are the most extensive geological unit in the Northern hemisphere. In contrast, the Southern hemisphere is dominated by outcropping consolidated terrain. In this work, we provide geomorphological maps of the Southern hemisphere with the distinction of both geological units and linear features. The geomorphological maps described in this study allow us to gain a better understanding of the processes shaping the comet nucleus and the distribution of primary structures such as fractures and strata.

  • Lennström, Lovisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Varumärkesskydd för varuutstyrslar: Särskilt om kravet på särskiljningsförmåga och former med tekniskt resultat eller betydande värde2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Ett varumärke används för att skydda ett kännetecken som en näringsidkare använder för att särskilja sina varor och tjänster från andra näringsidkares varor och tjänster. Varumärken fyller även ett konsumentintresse genom att garantera en varas ursprung. Vid en första anblick består varumärken framförallt av ord- och figurmärken t.ex. slogans och logotyper, men varumärkesbegreppet har förändrats i takt med den tekniska utvecklingen och numera kan även varuutstyrslar, färger, ljud och dofter varumärkesregistreras.

     

    För att formen på en vara, ofta kallad varuutstyrsel, ska kunna varumärkesregistreras krävs att den har särskiljningsförmåga dvs. den ska kunna användas för att särskilja en vara från andra varor på marknaden. Det uppställs formellt sett inte högre krav på särskiljningsförmåga för formvarumärken än för traditionella varumärken. Konsumenter är dock inte vana vid att uppfatta en varuutstyrsel som ett varumärke, vilket medför att en hög tröskel uppställs för varumärkes-registrering. För att en varuutstyrsel ska ha ursprunglig särskiljningsförmåga krävs att formen avviker från normen eller vad som är sedvanligt i branschen. En varuutstyrsel som saknar särskiljningsförmåga kan dock förvärva särskiljningsförmåga genom användning enligt artikel 4.4 VMD, vilket kräver att konsumenter identifierar varan som härrörande från en viss näringsidkare till följd av varuutstyrseln och inte något annat förekommande varumärke. Det är således inte tillräckligt att konsumenter känner igen formvarumärket och associerar det med näringsidkaren. Detta medför att förekomsten av ordmärken och andra varumärken som lättare uppfattas som ursprungsangivelser av konsumenter försvårar möjligheten att nå upp till kravet på särskiljningsförmåga för formvarumärken.

     

    Det uppställs vidare registreringshinder för former som endast är nödvändiga för att uppnå ett tekniskt resultat eller ger varan ett betydande värde i artikel 4.1.e) VMD. Det huvudsakliga syftet med artikel 4.1.e) VMD är att förhindra att skyddet för ett varumärke får konkurrensbegränsande effekter genom att ge innehavaren en ensamrätt till egenskaper hos en vara som konsumenter sannolikt kan komma att kräva hos konkurrenters varor.

     

    Enligt EU-domstolen är det endast när alla väsentliga särdrag hos en form är nödvändiga för att uppnå ett tekniskt resultat som registrering kan hindras enligt artikel 4.1.e.ii) VMD. Har ett varumärke en icke-funktionell beståndsdel som är en del av formens väsentliga karaktärsdrag kan dock varumärkesregistrering inte hindras, vilket medför problem med varumärkesregistrerade hybridformer som är delvis funktionella. En lösning är att tillämpa en generell syftesbaserad metod framtagen av AG Mengozzi i Lego-målet, där avgörande är om en varumärkesregistrering av en varuutstyrsel kan få en sådan konkurrensbegränsande effekt som registreringshindret i artikel 4.1.e) VMD syftar till att förhindra.

     

    Det generella syftet bakom registreringshindret i artikel 4.1.e.iii) VMD för former som ger varan ett betydande värde är, förutom att hindra konkurrensbegränsande varumärkesregistreringar, att dra en gräns mellan vad som ska skyddas varumärkesrättsligt och vad som ska skyddas genom t.ex. mönster- och upphovsrätten. Enligt min uppfattning kan detta syfte ifrågasättas, om en varuutstyrsel har särskiljningsförmåga och fungerar som ett varumärke saknas skäl att neka registrering till följd av att former traditionellt sett skyddas genom mönsterrätten. Det är även oförenligt med varumärkesbegreppets ständiga utveckling. Vidare kan de konkurrensmässiga effekterna vid varumärkesregistrering av en form som ger en vara ett betydande värde inte likställas med effekterna av varumärkesregistrering av en form nödvändig för att uppnå ett tekniskt resultat. Således finns det skäl att slopa registreringshindret för former som ger varan ett betydande värde.

  • Lai, Ian-Lin
    et al.
    Natl Cent Univ, Inst Space Sci, 300 Zhongda Rd, Taoyuan 32001, Taiwan..
    Ip, Wing-Huen
    Natl Cent Univ, Inst Space Sci, 300 Zhongda Rd, Taoyuan 32001, Taiwan.;Natl Cent Univ, Inst Astron, 300 Zhongda Rd, Taoyuan 32001, Taiwan.;Macau Univ Sci & Technol, Space Sci Inst, Taipa, Macau, Peoples R China..
    Su, Cheng-Chin
    Natl Chiao Tung Univ, Dept Mech Engn, 1001 Univ Rd, Hsinchu 300, Taiwan..
    Wu, Jong-Shinn
    Natl Chiao Tung Univ, Dept Mech Engn, 1001 Univ Rd, Hsinchu 300, Taiwan..
    Lee, Jui-Chi
    Natl Cent Univ, Dept Earth Sci, 300 Zhongda Rd, Taoyuan 32001, Taiwan..
    Lin, Zhong-Yi
    Natl Cent Univ, Inst Astron, 300 Zhongda Rd, Taoyuan 32001, Taiwan..
    Liao, Ying
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Thomas, Nicolas
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Sierks, Holger
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Barbieri, Cesare
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Lamy, Philippe
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille, France..
    Rodrigo, Rafael
    CSIC, INTA, Ctr Astrobiol, E-28850 Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Koschny, Detlef
    ESA, European Space Res & Technol Ctr, Sci Support Off, Keplerlaan 1,Postbus 299, NL-2201 AG Noordwijk, Netherlands..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland.
    Keller, Horst Uwe
    Tech Univ Carolo Wilhelmina Braunschweig, IGEP, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Agarwal, Jessica
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    A'Hearn, Michael F.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.;Univ Maryland, Dept Astron, College Pk, MD 20742 USA.;Akad Wissensch Gottingen, Gottingen, Germany..
    Barucci, Maria Antonella
    Univ Paris Diderot, Univ Pierre & Marie Curie, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Bertaux, Jean-Loup
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Bertini, Ivano
    Univ Padua, CISAS, Ctr Studies & Act Space G Colombo, Padua, Italy..
    Boudreault, Steven
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Cremonese, Gabriele
    INAF, Osservatorio Astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Da Deppo, Vania
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Debei, Stefano
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    De Cecco, Mariolino
    Univ Trento, Via Mesiano 77, I-38100 Trento, Italy..
    Deller, Jakob
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Fornasier, Sonia
    Univ Paris Diderot, Univ Pierre & Marie Curie, CNRS, LESIA,Observ Paris, 5 Pl J Janssen, F-92195 Meudon, France..
    Fulle, Marco
    INAF, Osservatorio Astron, Via Tiepolo 11, I-34014 Trieste, Italy..
    Groussin, Olivier
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille, France..
    Gutierrez, Pedro J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Guttler, Carsten
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Hofmann, Marc
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Hviid, Stubbe F.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Jorda, Laurent
    Aix Marseille Univ, CNRS, LAM, UMR 7326, 38 Rue Frederic Joliot Curie, F-13388 Marseille, France..
    Knollenberg, J. Org
    Kovacs, Gabor
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Kramm, J. -Rainer
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Kuhrt, Ekkehard
    Deutsch Zentrum Luft & Raumfahrt DLR, Inst Planeten Forsch, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kuppers, Michael
    ESA, European Space Astron Ctr, Operat Dept, POB 78, E-28691 Madrid, Spain..
    Lara, Luisa M.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Lazzarin, Monica
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Moreno, Jose J. Lopez
    Marzari, Francesco
    Univ Padua, Dept Phys & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy..
    Naletto, Giampiero
    Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Oklay, Nilda
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Shi, Xian
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Tubiana, Cecilia
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Vincent, Jean-Baptiste
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Gas outflow and dust transport of comet 67P/Churyumov-Gerasimenko2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S533-S546 p.Article in journal (Refereed)
    Abstract [en]

    Because of the diurnal thermal cycle and the irregular shape of the nucleus, gas outflow of comet 67P/Churyumov-Gerasimenko could be highly anisotropic as indicated by the colliminated dust jet structures on the sunlit side. Based on the OSIRIS imaging observations of the outgassing effect, a simple model of surface sublimation can be constructed by taking into account the dependence on the solar insolation. With preliminary information on the time variability of the global gas production rate, a sequence of gas coma models can be generated at different epochs before and after perihelion. We also investigate different patterns of dust particle dynamics under the influences of nuclear rotation and gas drag. From these considerations, a consistent picture of the spatial distribution of dusty materials across the surface of comet 67P as it moves around the perihelion can be developed. It is found that because of the redeposition of the ejected dust from the Southern hemisphere to the Northern hemisphere during the southern summer season the Hapi region could gain up to 0.4 m while the Wosret region would lose up to 1.8 m of dust mantle per orbit.

  • Grun, E.
    et al.
    Max Planck Inst Kernphys, Saupfercheckweg 1, D-69127 Heidelberg, Germany.;Univ Colorado, Lab Atmospher & Space Phys, 1234 Innovat Dr, Boulder, CO 80303 USA..
    Agarwal, J.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Altobelli, N.
    ESA, Camino Bajo Castillo S-N, E-28692 Madrid, Spain..
    Altwegg, K.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Bentley, M. S.
    Austrian Acad Sci, Space Res Inst, Schmiedlstr 6, A-8042 Graz, Austria..
    Biver, N.
    Univ Paris Diderot, UPMC, CNRS, LESIA,Observ Paris, 5 Pl Jules Janssen, F-92195 Meudon, France..
    Della Corte, V.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy..
    Edberg, Niklas J. T.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Feldman, P. D.
    Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA..
    Galand, M.
    Imperial Coll, South Kensington Campus, London SW7 2AZ, England..
    Geiger, B.
    ESA, Camino Bajo Castillo S-N, E-28692 Madrid, Spain..
    Goetz, C.
    TU Braunschweig, Inst Geophys & Extraterr Phys, D-38106 Braunschweig, Germany..
    Grieger, B.
    ESA, Camino Bajo Castillo S-N, E-28692 Madrid, Spain..
    Guettler, C.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Henri, P.
    CNRS, LPC2E, Orleans, France..
    Hofstadter, M.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Horanyi, M.
    Univ Colorado, Lab Atmospher & Space Phys, 1234 Innovat Dr, Boulder, CO 80303 USA..
    Jehin, E.
    Univ Liege, Inst Astrophys & Geophys, B-4000 Liege, Belgium..
    Krueger, H.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Lee, S.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Mannel, T.
    Austrian Acad Sci, Space Res Inst, Schmiedlstr 6, A-8042 Graz, Austria..
    Morales, E.
    Jaicoa Observ, Aguadilla, PR USA..
    Mousis, O.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France..
    Mueller, M.
    ESOC, ESA, Robert Bosch Str 5, Darmstadt, Germany..
    Opitom, C.
    Univ Liege, Inst Astrophys & Geophys, B-4000 Liege, Belgium..
    Rotundi, A.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy.;Univ Napoli Parthenope, Dip Sci & Tecnol, CDN IC4, I-80143 Naples, Italy..
    Schmied, R.
    Austrian Acad Sci, Space Res Inst, Schmiedlstr 6, A-8042 Graz, Austria.;Graz Univ, Inst Phys, Univ Pl 3, A-8010 Graz, Austria..
    Schmidt, F.
    Univ Stuttgart, Inst Raumfahrtsyst IRS, Pfaffenwaldring 29, D-70569 Stuttgart, Germany..
    Sierks, H.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Snodgrass, C.
    Open Univ, Dept Phys Sci, Planetary & Space Sci, Milton Keynes MK7 6AA, Bucks, England..
    Soja, R. H.
    Univ Stuttgart, Inst Raumfahrtsyst IRS, Pfaffenwaldring 29, D-70569 Stuttgart, Germany..
    Sommer, M.
    Univ Stuttgart, Inst Raumfahrtsyst IRS, Pfaffenwaldring 29, D-70569 Stuttgart, Germany..
    Srama, R.
    Univ Stuttgart, Inst Raumfahrtsyst IRS, Pfaffenwaldring 29, D-70569 Stuttgart, Germany..
    Tzou, C. -Y
    Vincent, J. -B
    Yanamandra-Fisher, P.
    Space Sci Inst, 13456 Cajon Creek Court, Rancho Cucamonga, CA 91739 USA..
    A'Hearn, M. F.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Eriksson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Barbieri, C.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Barucci, M. A.
    Univ Paris Diderot, UPMC, CNRS, LESIA,Observ Paris, 5 Pl Jules Janssen, F-92195 Meudon, France..
    Bertaux, J. -L
    Bertini, I.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giusepp Colomb, Via Venezia 15, I-35131 Padua, Italy..
    Burch, J.
    Southwest Res Inst, 6220 Culebra Rd, San Antonio, TX 78238 USA..
    Colangeli, L.
    European Space Agcy, European Space Res & Technol Ctr, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    Cremonese, G.
    Osserv Astron Padova, INAF, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Da Deppo, V.
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy..
    Davidsson, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Debei, S.
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy..
    De Cecco, M.
    Osserv Astron Trieste, INAF, Via Tiepolo 11, I-34143 Trieste, Italy..
    Deller, J.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Feaga, L. M.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Ferrari, M.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy..
    Fornasier, S.
    Univ Paris Diderot, UPMC, CNRS, LESIA,Observ Paris, 5 Pl Jules Janssen, F-92195 Meudon, France..
    Fulle, M.
    Osserv Astron Trieste, INAF, Via Tiepolo 11, I-34143 Trieste, Italy..
    Gicquel, A.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Gillon, M.
    Univ Liege, Inst Astrophys & Geophys, B-4000 Liege, Belgium..
    Green, S. F.
    Open Univ, Dept Phys Sci, Planetary & Space Sci, Milton Keynes MK7 6AA, Bucks, England..
    Groussin, O.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France..
    Gutierrez, P. J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Hofmann, M.
    Hviid, S. F.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Ip, W. -H
    Ivanovski, S.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy..
    Jorda, L.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France..
    Keller, H. U.
    TU Braunschweig, Inst Geophys & Extraterr Phys, D-38106 Braunschweig, Germany..
    Knight, M. M.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA..
    Knollenberg, J.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Koschny, D.
    European Space Agcy, European Space Res & Technol Ctr, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    Kramm, J. -R
    Kuehrt, E.
    DLR, Inst Planetary Res, Rutherfordstr 2, D-12489 Berlin, Germany..
    Kuppers, M.
    ESA, Camino Bajo Castillo S-N, E-28692 Madrid, Spain..
    Lamy, P. L.
    CNRS, UMR 7326, Lab Astrophys Marseille, 38 Rue Federic Joliot Curie, F-13388 Marseille 13, France.;Aix Marseille Univ, 38 Rue Federic Joliot Curie, F-13388 Marseille 13, France..
    Lara, L. M.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron, E-18008 Granada, Spain..
    Lazzarin, M.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Lopez-Moreno, J. J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron S-N, E-18008 Granada, Spain..
    Manfroid, J.
    Univ Liege, Inst Astrophys & Geophys, B-4000 Liege, Belgium..
    Epifani, E. Mazzotta
    OAR, INAF, Via Frascati 33, I-00078 Rome, Italy..
    Marzari, F.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Osservatorio 3, I-35122 Padua, Italy..
    Naletto, G.
    Univ Padua, Ctr Ateneo Studi Attivita Spaziali Giusepp Colomb, Via Venezia 15, I-35131 Padua, Italy.;Univ Padua, Dept Informat Engn, Via Gradenigo 6-B, I-35131 Padua, Italy..
    Oklay, N.
    Palumbo, P.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy.;Univ Napoli Parthenope, Dip Sci & Tecnol, CDN IC4, I-80143 Naples, Italy..
    Parker, J. Wm.
    Southwest Res Inst, 1050 Walnut St,Suite 300, Boulder, CO 80302 USA..
    Rickman, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics. PAS Space Res Ctr, Poland.
    Rodrigo, R.
    ESA, Camino Bajo Castillo S-N, E-28692 Madrid, Spain.;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland..
    Rodriguez, J.
    CSIC, Inst Astrofis Andalucia, Glorieta Astron S-N, E-18008 Granada, Spain..
    Schindhelm, E.
    Southwest Res Inst, 1050 Walnut St,Suite 300, Boulder, CO 80302 USA..
    Shi, X.
    Sordini, R.
    INAF, IAPS, Via Fosso Cavaliere, I-00133 Rome, Italy..
    Steffl, A. J.
    Southwest Res Inst, 1050 Walnut St,Suite 300, Boulder, CO 80302 USA..
    Stern, S. A.
    Southwest Res Inst, 1050 Walnut St,Suite 300, Boulder, CO 80302 USA..
    Thomas, N.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Tubiana, C.
    Max Planck Inst Sonnensyst Forsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany..
    Weaver, H. A.
    Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA..
    Weissman, P.
    Planetary Sci Inst, 1700 East Ft Lowell,Suite 106, Tucson, AZ 85719 USA..
    Zakharov, V. V.
    Univ Paris Diderot, UPMC, CNRS, LESIA,Observ Paris, 5 Pl Jules Janssen, F-92195 Meudon, France.;UPMC Univ Paris 06, CNRS, Sorbonne Univ, Lab Meteorol Dynam, 4 Pl Jussieu, F-75252 Paris, France..
    The 2016 Feb 19 outburst of comet 67P/CG: an ESA Rosetta multi-instrument study2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, S220-S234 p.Article in journal (Refereed)
    Abstract [en]

    On 2016 Feb 19, nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ranging from UV over visible to microwave wavelengths, in situ gas, dust and plasma instruments, and one dust collector. At 09: 40 a dust cloud developed at the edge of an image in the shadowed region of the nucleus. Over the next two hours the instruments recorded a signature of the outburst that significantly exceeded the background. The enhancement ranged from 50 per cent of the neutral gas density at Rosetta to factors > 100 of the brightness of the coma near the nucleus. Dust related phenomena (dust counts or brightness due to illuminated dust) showed the strongest enhancements (factors > 10). However, even the electron density at Rosetta increased by a factor 3 and consequently the spacecraft potential changed from similar to-16 V to -20 V during the outburst. A clear sequence of events was observed at the distance of Rosetta ( 34 km from the nucleus): within 15 min the Star Tracker camera detected fast particles (similar to 25 m s(-1)) while 100 mu m radius particles were detected by the GIADA dust instrument similar to 1 h later at a speed of 6 m s(-1). The slowest were individual mm to cm sized grains observed by the OSIRIS cameras. Although the outburst originated just outside the FOV of the instruments, the source region and the magnitude of the outburst could be determined.

  • Deijen, Charlotte L.
    et al.
    Vrije Univ Amsterdam.
    Vasmel, Jeanine E.
    Vrije Univ Amsterdam.
    de Lange-de Klerk, Elly S. M.
    Vrije Univ Amsterdam.
    Cuesta, Miguel A.
    Vrije Univ Amsterdam.
    Coene, Peter-Paul L. O.
    Maasstad Hosp, Rotterdam, Netherlands..
    Lange, Johan F.
    Erasmus MC, Rotterdam, Netherlands..
    Meijerink, W. J. H. Jeroen
    Vrije Univ Amsterdam.
    Jakimowicz, Jack J.
    Delft Univ Technol.
    Jeekel, Johannes
    Erasmus MC, Dept Surg, Rotterdam.
    Kazemier, Geert
    Vrije Univ Amsterdam.
    Janssen, Ignace M. C.
    Rijnstate Hosp, Dept Surg, Arnhem.
    Påhlman, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Haglind, Eva
    Sahlgrens Univ Hosp.
    Bonjer, H. Jaap
    Vrije Univ Amsterdam.
    Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer2017In: Surgical Endoscopy, ISSN 0930-2794, E-ISSN 1432-2218, Vol. 31, no 6, 2607-2615 p.Article in journal (Refereed)
    Abstract [en]

    Laparoscopic surgery for colon cancer is associated with improved recovery and similar cancer outcomes at 3 and 5 years in comparison with open surgery. However, long-term survival rates have rarely been reported. Here, we present survival and recurrence rates of the Dutch patients included in the COlon cancer Laparoscopic or Open Resection (COLOR) trial at 10-year follow-up. Between March 1997 and March 2003, patients with non-metastatic colon cancer were recruited by 29 hospitals in eight countries and randomised to either laparoscopic or open surgery. Main inclusion criterion for the COLOR trial was solitary adenocarcinoma of the left or right colon. The primary outcome was disease-free survival at 3 years, and secondary outcomes included overall survival and recurrence. The 10-year follow-up data of all Dutch patients were collected. Analysis was by intention-to-treat. The trial was registered at ClinicalTrials.gov (NCT00387842). In total, 1248 patients were randomised, of which 329 were Dutch. Fifty-eight Dutch patients were excluded and 15 were lost to follow-up, leaving 256 patients for 10-year analysis. Median follow-up was 112 months. Disease-free survival rates were 45.2 % in the laparoscopic group and 43.2 % in the open group (difference 2.0 %; 95 % confidence interval (CI) -10.3 to 14.3; p = 0.96). Overall survival rates were 48.4 and 46.7 %, respectively (difference 1.7 %; 95 % CI -10.6 to 14.0; p = 0.83). Stage-specific analysis revealed similar survival rates for both groups. Sixty-two patients were diagnosed with recurrent disease, accounting for 29.4 % in the laparoscopic group and 28.2 % in the open group (difference 1.2 %; 95 % CI -11.1 to 13.5; p = 0.73). Seven patients had port- or wound-site recurrences (laparoscopic n = 3 vs. open n = 4). Laparoscopic surgery for non-metastatic colon cancer is associated with similar rates of disease-free survival, overall survival and recurrences as open surgery at 10-year follow-up.

  • Jonsson, Diana
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Lindberg, Fanny
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Comparisons of sulfate deposition rates in arctic and alpine ice cores with anthropogenic sulfur dioxide emission rates in the northern hemisphere2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Sulfur is a naturally occurring element on the Earth and in the atmosphere. When sulfur reacts with oxygen it forms sulfur dioxide (SO2), which later forms sulfate (SO42-). Historically, SO2 has been emitted to the atmosphere from volcanic eruptions, oceanic sea-spray and by forest fires. Since the beginning of the industrial revolution, anthropogenic emissions have increased dramatically. This is due to the increased industrial emissions, in particular sulfide ore mining and smelting of nonferrous metals. Burning of fossil fuels is also one of the biggest contributing factors. The increased SO2 emissions have greatly affected the climate and environment. An increased amount of SO42- in the atmosphere have resulted in less solar radiation and increased acid precipitation. Acid precipitation lowers the pH in soils, lakes and streams, which adversely affects the wildlife. This study investigates how changes in anthropogenic SO2 emissions from ten regions in the Northern Hemisphere over the past ~40-50 years are reflected in records of atmospheric SO42- deposition from seven arctic and alpine glacier ice cores. The correlation betweenSO2 emissions and SO42- deposition is quantified using least-squares linear regression. The study shows that over the period of interest, SO2 emissions have decreased in all regions except China/Mongolia and Japan/Korea. It also shows that SO42- deposition has decreased in nearly all ice-core records over the same approximate period, with the exception of a core from Tibet. The results show a generally correlation between SO2 emission trends in Northern Hemisphere regions and SO42- deposition in ice cores, but since many regression lines are similar, the most influential SO2 emission regions for any given ice-core site cannot always be identified with certainty.