uu.seUppsala University Publications
3456789 251 - 300 of 606
rss atomLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
  • Ericson, Jenny
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Falun Cent Hosp, Dept Pediat, Falun, Sweden;Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
    Palmer, Lina
    Univ Boras, Fac Caring Sci Work Life & Social Welf, Boras, Sweden.
    Mothers of preterm infants' experiences of breastfeeding support in the first 12months after birth: A qualitative study2019In: Birth, ISSN 0730-7659, E-ISSN 1523-536X, Vol. 46, no 1, p. 129-136Article in journal (Refereed)
    Abstract [en]

    Background

    Breastfeeding support is important for breastfeeding mothers; however, it is less clear how mothers of preterm infants (< 37 gestational weeks) experience breastfeeding support during the first year. Thus, the aim of this study was to describe how mothers of preterm infants in Sweden experience breastfeeding support during the first 12 months after birth.

    Methods

    This qualitative study used data from 151 mothers from questionnaires with open‐ended questions and telephone interviews. The data were analyzed using an inductive thematic network analysis with a hermeneutical approach.

    Results

    The results exposed two organizing themes and one global theme. In the organizing theme “genuine support strengthens,” the mothers described how they were strengthened by being listened to and met with respect, understanding, and knowledge. The support was individually adapted and included both practical and emotional support. In the organizing theme “inadequate support diminishes,” the mothers described how health professionals who were controlling and intrusive diminished them and how the support they needed was not provided or was inappropriate. Thus, the global theme “being thrown into a lottery—dependent on the health professional who provided breastfeeding support” emerged, meaning that the support received was random in terms of knowledge and support style, depending on the individual health professionals who were available.

    Conclusion

    Breastfeeding support to mothers of preterm infants was highly variable, either constructive or destructive depending on who provided support. This finding clearly shows major challenges for health care, which should make breastfeeding support more person‐centered, equal, and supportive in accordance with individual needs.

  • Thulin, Mats
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Decarlo, Anjanette
    Aromat Plant Res Ctr, 230 N 1200 E,Suite 100, Lehi, UT 84604 USA.
    Johnson, Stephen P.
    Aromat Plant Res Ctr, 230 N 1200 E,Suite 100, Lehi, UT 84604 USA.
    Boswellia occulta (Burseraceae), a new species of frankincense tree from Somalia (Somaliland)2019In: Phytotaxa, ISSN 1179-3155, E-ISSN 1179-3163, Vol. 394, no 3, p. 219-224Article in journal (Refereed)
    Abstract [en]

    The new species Boswellia occulta is described from a small area in the Ceel Afweyn District of Somaliland (northwestern Somalia), where it is locally of considerable socio-economic importance. Although used for frankincense production by many generations of local harvesters, it has been unknown to science until now. Apart from the recently collected type material, it is also known from a sterile and hitherto misunderstood collection made in 1945. The simple-leaved Boswellia occulta is morphologically compared with B. sacra and B. frereana, the two major frankincense-producing species in the region, both with imparipinnate leaves, and it appears to be most closely related to B. sacra. The new species is the only simple-leaved species of Boswellia known outside Socotra.

  • Castello, Sveva
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Galaxy clusters and cosmic voids in modified gravity scenarios2019Student paper other, 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The so-called 'cosmic web', comprising cosmic voids and galaxy clusters, has been proven to be extremely sensitive to deviations from General Relativity. This could be further investigated by future large-scale surveys, such as with the European Space Agency satellite Euclid. In this study, the parameter |fR0| from f(R) gravity is constrained by considering the Euclid survey specications to predict the observed numbers of voids and clusters in bins of redshift, mass and, only for voids, density contrast. From these values, the Fisher matrix is computed for three values of |fR0|, 10-4, 10-6 and 10-8, by assuming a flat Universe with a component that mimics the cosmological constant. The probability density functions are obtained for |fR0| and seven other parameters from the fiducial model considered (ns, h, Ωb, Ωm, σ8, w0 and wa).

  • Mansky, Maximilian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Applied Mathematics and Statistics. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Mapping from physical events to words using neural networks: A case study on football2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Public defence: 2019-05-03 13:00 Sal IV, Uppsala
    Juvrud, Joshua
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    The perception of actions and interactions: And the importance of context2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The perception of actions and interactions is a dynamic process linked with perceptual processes, the internal and external states of the individual, prior experiences, and the immediate environment. Given these differential contexts, it is very likely there are differences in how infants perceive, interpret, and respond to actions. The present thesis took a developmental and individual differences approach to understanding action perception and processing in infancy. The overarching aim was to understand the development of action perception and how individual differences contribute to the perception and processing of actions. More specifically, individual differences included the capacity to which variations in a child’s context can affect the development of action perception. Study I demonstrated that, like adults, infants could differentiate between physically possible and physically impossible apparent motion paths, as evidenced by pupil dilation. This perception may be related to the context of whether the motion was performed by a human figure or an object. Study II found that in the context of a more complex social interaction, infants differentiated between appropriate and inappropriate responses to a giving action. Furthermore, infants’ individual differences in perceiving a giving action were related to their own giving behaviors later in childhood, suggesting possible specialized mechanisms. Study III took an integrative perspective on context and demonstrated the joint impact of internal and external emotional contexts for infants’ subsequent selective attention during visual search. Infants’ visual attention was affected by previous exposure to a facial emotion and by the mothers’ negative affect. The results of these three studies demonstrate that given differential environmental contexts and experiences, there are differences in how individuals perceive and interpret actions and interactions. Together, this thesis proposes an integrative role of context in perception and demonstrates that perception can never be truly decontextualized.

    List of papers
    1. Context dependent perception of apparent motion in 12-month-old infants and adults
    Open this publication in new window or tab >>Context dependent perception of apparent motion in 12-month-old infants and adults
    (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322Article in journal (Other academic) Submitted
    Abstract [en]

    The current study examines if 12-month-old infants and adults perceptions of apparent motion stimuli are context dependent by measuring sensitivity to possible and impossible apparent motion performed by a human figure.  In Study 1, infants and adults viewed an apparent motion stimulus comprising of an arm moving from one side of a leg to the other. Results showed that both infants and adults reacted with larger pupil dilation when observing an impossible apparent motion, that is, larger pupil dilation when it appears that a hand passed through the leg as opposed to moving around the leg. Study 2 found no such effect when 12-month-old infants observed an object control stimulus with perceptually similar properties. These findings suggest that apparent motion perception is context dependent and that the constraints of the human body and human actions are taken into account when perceiving rapidly changing static images as fluid motion.

    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-379488 (URN)
    Available from: 2019-03-17 Created: 2019-03-17 Last updated: 2019-03-17
    2. Longitudinal Continuity in Understanding and Production of Giving-Related Behavior From Infancy to Childhood
    Open this publication in new window or tab >>Longitudinal Continuity in Understanding and Production of Giving-Related Behavior From Infancy to Childhood
    Show others...
    2019 (English)In: Child Development, ISSN 0009-3920, E-ISSN 1467-8624, Vol. 90, no 2, p. e182-e191Article in journal (Refereed) Published
    Abstract [en]

    Infants have an early understanding of giving (the transfer of an item by one agent to another), but little is known about individual differences in these abilities or their developmental outcomes. Here, 9-month-olds (N = 59) showing clearer neural processing (Event-related potential, ERP) of a give-me gesture also evidenced a stronger reaction (pupil dilation) to an inappropriate response to a give-me gesture, and at 2 years were more likely to give in response to a give-me gesture. None of the differences in understanding and production of giving-related behaviors were associated with other sociocognitive variables investigated: language, gaze-following, and nongiving helping. The early developmental continuity in understanding and production of giving behavior is consistent with the great importance of giving for humans throughout the life span.

    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-370001 (URN)10.1111/cdev.13131 (DOI)000460664900001 ()30102423 (PubMedID)
    Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-04-11Bibliographically approved
    3. How infants view the world: The functional role of emotional context and maternal affect
    Open this publication in new window or tab >>How infants view the world: The functional role of emotional context and maternal affect
    (English)In: Developmental Science, ISSN 1363-755X, E-ISSN 1467-7687Article in journal (Other academic) Submitted
    Abstract [en]

    Individual differences in their emotional context may differentially impact infants’ ability to selectively encode and learn from their environment. The current study takes an integrative approach in considering three emotional contexts that have independently been found to modulate infants’ allocation of selective attention: maternal negative affect, infant temperament, and an emotional face prime (the mother and a stranger’s face). The study looked at the effects of that these contexts had on 9-month-old infants’ performance on a subsequent eye-tracking visual search task. Results revealed that infants were faster to find the target after viewing their mother’s angry face or a fearful face, regardless of familiarity. When the mother reported high negative affect, infants’ visual search performance was increasingly impacted by a fearful face, resulting in significantly faster visual search times. The findings demonstrate that both immediate emotional face prime and the mother’s negative affect have the capacity to influence what infants attend to and consequently influence their processing of information in their environment.

    National Category
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-379489 (URN)
    Available from: 2019-03-17 Created: 2019-03-17 Last updated: 2019-03-17
  • Wu, Chenglin
    et al.
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Simonetti, Michele
    Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Rossell, Carla
    Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Mignardi, Marco
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Mirzazadeh, Reza
    Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Annaratone, Laura
    Univ Turin, Dept Med Sci, Corso Dogliotti 14, I-10126 Turin, Italy.
    Marchio, Caterina
    Univ Turin, Dept Med Sci, Corso Dogliotti 14, I-10126 Turin, Italy;IRCCS, Candiolo Canc Inst FPO, Pathol Unit, Str Prov 142, I-10060 Candiolo, TO, Italy.
    Sapino, Anna
    Univ Turin, Dept Med Sci, Corso Dogliotti 14, I-10126 Turin, Italy;IRCCS, Candiolo Canc Inst FPO, Pathol Unit, Str Prov 142, I-10060 Candiolo, TO, Italy.
    Bienko, Magda
    Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Crosetto, Nicola
    Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    Nilsson, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Tomtebodavagen 23a, S-17165 Stockholm, Sweden.
    RollFISH achieves robust quantification of single-molecule RNA biomarkers in paraffin-embedded tumor tissue samples2018In: COMMUNICATIONS BIOLOGY, ISSN 2399-3642, Vol. 1, article id 209Article in journal (Refereed)
    Abstract [en]

    Single-molecule RNA fluorescence in situ hybridization (smFISH) represents a promising approach to quantify the expression of clinically useful biomarkers in tumor samples. However, routine application of smFISH to formalin-fixed, paraffin-embedded (FFPE) samples is challenging due to the low signal intensity and high background noise. Here we present RollFISH, a method combining the specificity of smFISH with the signal boosting of rolling circle amplification. We apply RollFISH to quantify widely used breast cancer biomarkers in cell lines and FFPE samples. Thanks to the high signal-to-noise ratio, we can visualize selected biomarkers at low magnification (20 x) across entire tissue sections, and thus assess their spatial heterogeneity. Lastly, we apply RollFISH to quantify HER2 mRNA in 150 samples on a single tissue microarray, achieving a sensitivity and specificity of detection of HER2-positive samples of similar to 90%. RollFISH is a robust method for quantifying the expression and intratumor heterogeneity of biomarkers in FFPE tissues.

  • Public defence: 2019-05-07 09:00 Sal IX, Uppsala
    Hagerman, Heidi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
    Working Life Among First-Line Managers and Their Subordinates in Elderly Care: an Empowerment Perspective2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Aim: The aim of this thesis was to study the working life of first-line managers and their subordinates in elderly care from an empowerment perspective. Methods: Paper I and II used a qualitative approach, and semi-structured interviews were conducted with 14 male and 14 female first-line managers. Data were analyzed using qualitative content analysis. Paper III and IV used a quantitative approach with a longitudinal, correlational and multilevel design. 78 first-line managers and 1398 subordinates filled in the questionnaire at T1 and 56 first-line managers and 769 subordinates at T2. Data were analyzed using descriptive statistics, multivariate analyses (III & IV) and multilevel modelling (IV). Results: In Paper I and II, the first-line managers reported having a challenging and complex work situation. Although the first-line managers sometimes expressed a need for better access to structural empowerment in terms of information, resources and support, they experienced psychological empowerment in their work. In Paper III, the results indicated that the more access the first-line managers had to structural empowerment over time, the more likely they were to feel psychologically empowered over time, resulting in lower ratings of their stress symptoms and higher ratings of their own self-rated leadership-management performance over time. Another finding in Paper III was the influence the number of subordinates per first-line manager had on the first-line managers’ ratings of structural empowerment and the subordinates’ ratings of structural empowerment and stress symptoms. In Paper IV, the results indicate that the more access the first-line managers had to structural empowerment at T1, the more access the subordinates had to structural empowerment at T2, and the higher the subordinates rated their first-line manager’s leadership-management performance at T2, when controlling for psychological empowerment. Conclusions: The working life of first-line managers in elderly care is complex and challenging, and they seem to need better access to structural empowerment (Paper I-IV). However, although deficiencies in access to structural empowerment were reported, the first-line managers experienced their work as a positive challenge (Paper 1) and felt that, though the work was not easy, it was worth it (Paper II).

    List of papers
    1. Male first-line managers' experiences of the work situation in elderly care: an empowerment perspective
    Open this publication in new window or tab >>Male first-line managers' experiences of the work situation in elderly care: an empowerment perspective
    Show others...
    2015 (English)In: Journal of Nursing Management, ISSN 0966-0429, E-ISSN 1365-2834, Vol. 23, no 6, p. 695-704Article in journal (Refereed) Published
    Abstract [en]

    AIM: To describe male first-line managers' experiences of their work situation in elderly care.

    BACKGROUND: First-line managers' work is challenging. However, less attention has been paid to male managers' work situation in health care. Knowledge is needed to empower male managers.

    METHOD: Fourteen male first-line managers were interviewed. The interview text was subjected to qualitative content analysis.

    RESULT: Work situations were described as complex and challenging; challenges were the driving force. They talked about 'Being on one's own but not feeling left alone', 'Having freedom within set boundaries', 'Feeling a sense of satisfaction and stimulation', 'Feeling a sense of frustration' and 'Having a feeling of dejection and resignation'.

    CONCLUSION: Although the male managers report deficiencies in the support structure, they largely experience their work as a positive challenge.

    IMPLICATIONS FOR NURSING MANAGEMENT: To meet increasing challenges, male first-line managers need better access to supportive structural conditions. Better access to resources is needed in particular, allowing managers to be more visible for staff and to work with development and quality issues instead of administrative tasks. Regarding organisational changes and the scrutiny of management and the media, they lack and thus need support and information from superiors.

    National Category
    Nursing
    Identifiers
    urn:nbn:se:uu:diva-244392 (URN)10.1111/jonm.12197 (DOI)000360840300002 ()24283766 (PubMedID)
    Available from: 2015-02-16 Created: 2015-02-16 Last updated: 2019-03-15Bibliographically approved
    2. How do female first-line managers in elderly care experience their work situation? – an interview study
    Open this publication in new window or tab >>How do female first-line managers in elderly care experience their work situation? – an interview study
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Nursing
    Research subject
    Caring Sciences
    Identifiers
    urn:nbn:se:uu:diva-378707 (URN)
    Funder
    AFA Insurance
    Available from: 2019-03-08 Created: 2019-03-08 Last updated: 2019-03-15
    3. A longitudinal study of working life among first-line managers in the care of older adults
    Open this publication in new window or tab >>A longitudinal study of working life among first-line managers in the care of older adults
    Show others...
    2016 (English)In: Applied Nursing Research, ISSN 0897-1897, E-ISSN 1532-8201, Vol. 32, p. 7-13Article in journal (Refereed) Published
    Abstract [en]

    Aim: To study whether the number of subordinates plays a role in first-line managers' and subordinates' ratings of empowerment, stress symptoms, and leadership-management performance. The aim was also to study relationships between managers' empowerment and stress symptoms and leadership-management performance. Methods: A longitudinal and correlational design was used. All first-line managers (n = 98) and their subordinates (n = 2085) working in the care of older adults in five municipalities were approached. Results: With fewer (<= 30) subordinates per manager, there were higher ratings of structural empowerment among managers and subordinates and lower stress symptoms among subordinates, than with >= 31 subordinates. Furthermore, structural empowerment was related to the managers' stress symptoms and leadership management performance, mediated through psychological empowerment Moreover, structural empowerment can control/adjust for large numbers of subordinates in relation to stress symptoms. Conclusion: The higher FLMs rated their access to empowerment, the lower stress symptoms and higher leadership-management performance they rated over time.

    Keywords
    First-line manager, Leadership-management performance, Number of subordinates, Stress symptoms, Structural and psychological empowerment
    National Category
    Nursing
    Identifiers
    urn:nbn:se:uu:diva-310763 (URN)10.1016/j.apnr.2016.03.003 (DOI)000388057100002 ()27969055 (PubMedID)
    Funder
    AFA Insurance
    Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2019-03-15Bibliographically approved
    4. Empowerment and performance of managers and subordinates in elderly care: A longitudinal and multilevel study
    Open this publication in new window or tab >>Empowerment and performance of managers and subordinates in elderly care: A longitudinal and multilevel study
    Show others...
    2017 (English)In: Journal of Nursing Management, ISSN 0966-0429, E-ISSN 1365-2834, Vol. 25, no 8, p. 647-656Article in journal (Refereed) Published
    Abstract [en]

    AIM: To investigate relationships between first-line managers' ratings of structural and psychological empowerment, and the subordinates' ratings of structural empowerment, as well as their ratings of the managers' leadership-management performance.

    BACKGROUND: Work situations in elderly care are complex. To date, few studies have used a longitudinal, correlational and multilevel design to study the working life of subordinates and managers.

    METHOD: In five Swedish municipalities, questionnaires were answered twice during 2010-12 by 56 first-line managers and 769 subordinates working in nursing homes or home-help services.

    RESULTS: First-line managers' empowerment at Time 1 partially predicted subordinate's structural empowerment and ratings of their managers' leadership-management performance at Time 2. Changes over time partially revealed that the more access managers had to structural empowerment, i.e. increase over time, the higher the ratings were for structural empowerment and managerial leadership-management performance among subordinates.

    CONCLUSIONS: Findings strengthen research and theoretical suggestions linking first-line managers' structural empowerment to their subordinates' structural empowerment and ratings of their manager's leadership-management performance.

    IMPLICATIONS FOR NURSING MANAGEMENT: Managers with high access to structural empowerment are more likely to provide subordinates access to structural empowerment.

    Keywords
    first-line manager, leadership-management performance, linear mixed model, structural and psychological empowerment, subordinate
    National Category
    Nursing
    Identifiers
    urn:nbn:se:uu:diva-331770 (URN)10.1111/jonm.12504 (DOI)000414511300009 ()28714218 (PubMedID)
    Funder
    AFA Insurance
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2019-03-15Bibliographically approved
  • Finnes, Anna
    et al.
    Karolinska Inst, Div Psychol, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.
    Enebrink, Pia
    Karolinska Inst, Div Psychol, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.
    Ghaderi, Ata
    Karolinska Inst, Div Psychol, Dept Clin Neurosci, Nobels Vag 9, S-17177 Stockholm, Sweden.
    Dahl, JoAnne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Nager, Anna
    Karolinska Inst, Div Family Med & Primary Hlth Care, Dept Neurobiol Care Sci & Soc, Riddarstigen 30, S-18330 Stockholm, Sweden.
    Öst, Lars-Göran
    Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
    Psychological treatments for return to work in individuals on sickness absence due to common mental disorders or musculoskeletal disorders: a systematic review and meta-analysis of randomized-controlled trials2019In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 92, no 3, p. 273-293Article, review/survey (Refereed)
    Abstract [en]

    Purpose: Common mental disorders (CMDs) and musculoskeletal disorders are highly prevalent in the population and cause significant distress and disability, and high costs to society. The main objective of this systematic review and meta-analysis was to examine the outcome and comparative effectiveness of psychological interventions in reducing sickness absence (SA) due to CMDs or musculoskeletal disorders, compared to a waitlist control group, usual care or another clinical intervention.

    Methods: We reviewed 3515 abstracts of randomized controlled trials published from 1998 to 2017. Of these, 30 studies were included in the analysis.

    Results: The psychological interventions were overall more effective than treatment as usual in reducing SA (small effect sizes), but not compared to other clinical interventions. Results were similar for studies on CMDs and musculoskeletal pain. A few significant moderating effects were found for treatment-specific variables. However, these were difficult to interpret asthey pointed in different directions.

    Conclusion: There was a small but significant effect of psychological treatments in reducing SA. We identified areas of improvement such as methodological problems among the included studies and failure to specifically address RTW in the interventions that were evaluated. Clinical implications of the findings, and ways of improving methodological rigour of future studies are discussed.

  • Karasu, Ebru
    et al.
    Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Ulm, Germany.
    Nilsson, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Köhl, Jörg
    Univ Lubeck, Inst Syst Inflammat Res ISEF, Lubeck, Germany;Cincinnati Childrens Hosp, Div Immunobiol, Cincinnati, OH USA.
    Lambris, John D.
    Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
    Huber-Lang, Markus
    Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Ulm, Germany.
    Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction2019In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, article id 543Article, review/survey (Refereed)
    Abstract [en]

    Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. However, depending on the origin and extent of the damaged macro- and micro-milieu, the complement system can also be either excessively activated or inhibited. In both cases, this can lead to a maladaptive immune response and subsequent multiple cellular and organ dysfunction. The arsenal of complement-specific drugs offers promising strategies for various critical conditions after trauma, hemorrhagic shock, sepsis, and multiple organ failure. The imbalanced immune response needs to be detected in a rational and real-time manner before the translational therapeutic potential of these drugs can be fully utilized. Overall, the temporal-spatial complement response after tissue trauma and during sepsis remains somewhat enigmatic and demands a clinical triad: reliable tissue damage assessment, complement activation monitoring, and potent complement targeting to highly specific rebalance the fluid phase innate immune response.

  • Scheutwinkel, Kilian Hikaru
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Spectroscopy of the Globular Cluster M302019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Globular Clusters contain very old metal-poor stars in different evolutionary stages evolved from the same primordial cloud. Signatures of atomic in stellar interiors are studied in the metal-poor GC M30. Furthermore, traces of cluster internal pollution depleting alpha elements e.g. Mg & O are also found through high precision spectroscopy, which favors the existence of multiple stellar populations within a Globular Cluster. In this work, I use spectroscopic observations of 177 sample stars using the multi object spectrograph GIRAFFE and increasing the initial size of 12 of Scheutwinkel (2018) by 13 new UVES spectrograph sample stars of the Globular Cluster M30 ([Fe/H] = -2.3). The abundances of Fe, Ti, Mg & Ba (GIRAFFE) and Fe, Na, Al & Mg (UVES) are derived through the graphical spectrum analysis program SIU with VI broadband photometric stellar input parameters. The underlying line-formation theory is in LTE and uses 1-dimensional hydrostatic plan-parallel MAFAGS atmospheres with mixing length convection. We confirm an Al-Mg anti-correlation (Spearman ϱs= -0.583) and a correlation (Spearman ϱs= 0.641) between Al-Na in RGB stars as a direct result of being the partner elements of the depleted alpha elements Mg & O caused through NeNa, ON and MgAl cycles. We find similar element ratios [X/Fe] as Carretta et al. (2018) & O‘Malley et al. (2018) favoring the prior existence of multiple stellar populations within M30. Furthermore, we detected a signifcant restoration of abundances in the elements Fe, Mg & Ba towards RGB stars. Fe, Mg and Ti are matching the predictions of the diffusion model T5.8 (Richard et al. 2005) reasonably well. For Ba, we have no current atomic diffusion modeling, so the validation of the results is not possible. The trend of Ti is v-shaped presumably due to stronger radiative accelaration effects for this element. Overall our relative abundance trends are consistent with other Globular Cluster studies by Gruyters et al. (2013&2016), Korn et al. (2007) & Lind (2007).

  • Schnabel, Georg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Derivation of the Monte Carlo version of the marginal likelihoodManuscript (preprint) (Other academic)
  • Eriksson, Jonas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Roy, Tamal
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Sawadjoon, Supaporn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Bachmann, Kim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Sköld, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Larhed, Mats
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Weis, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Selvaraju, Ramkumar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preclinical PET-MRI Platform.
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Eriksson, Olof
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Odell, Luke R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell massIn: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667Article in journal (Refereed)
    Abstract [en]

    Introduction: MK-7246 is a potent and selective antagonist for chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Within the pancreas CRTH2 is selectively expressed in pancreatic β-cells where it is believed to play a role in insulin release. Reduction in β-cell mass and insufficient insulin secretion in response to elevated blood glucose levels is a hallmark for type 1 and type 2 diabetes. Reported here is the synthesis of [11C]MK-7246 and initial preclinical evaluation towards CRTH2 imaging. The aim is to develop a method to quantify β-cell mass with PET and facilitate non-invasive studies of disease progression in individuals with type 2 diabetes.

    Methods: The precursor N-desmethyl-O-methyl MK-7246 was synthesized in seven steps and subjected to methylation with [11C]methyl iodide followed by hydrolysis to obtain [11C]MK-7246 labelled in the N-methyl position. Preclinical evaluation included in vitro radiography and immune-staining performed in human pancreatic biopsies. Biodistribution studies were performed in rat by PET-MRI and in pig by PET-CT imaging. The specific tracer uptake was examined in pig by scanning before and after administration of MK-7246 (1 mg/kg). Predicted dosimetry of [11C]MK-7246 in human males was estimated based on the biodistribution in rat.

    Results: [11C]MK-7246 was obtained with activities sufficient for the current investigations (270±120 MBq) and a radiochemical purity of 93±2%. The tracer displayed focal binding in areas with insulin positive islet of Langerhans in human pancreas sections. Baseline uptake in pig was significantly reduced in CRTH2-rich areas after administration of MK-7246; pancreas (66% reduction) and spleen (88% reduction). [11C]MK-7246 exhibited a safe human predicted dosimetry profile as extrapolated from the rat biodistribution data.

    Conclusions: Initial preclinical in vitro and in vivo evaluation of [11C]MK-7246 show binding and biodistribution properties suitable for PET imaging of CRTH2. Further studies are warranted to assess its potential in β-cell mass imaging and CRTH2 drug development.

  • Nordlander, Måns
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    A defining issue in a defining time: Climate change as a security threat in the United Nations Security Council2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Andersson, Bo
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, German.
    Kytö, Merja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of English.
    Introduction: Exploring the Multifaceted Faces of Punctuation2018In: Studia Neophilologica, ISSN 0039-3274, E-ISSN 1651-2308, Vol. 90, no Suppl. 1, p. 1-4Article in journal (Other academic)
  • Jennstål, Julia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Öberg, PerOla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    The ethics of deliberative activism: in search of reasonableness and dialogic responsiveness in provocative art exhibitions2019In: Policy Studies, ISSN 0144-2872, E-ISSN 1470-1006Article in journal (Refereed)
    Abstract [en]

    “Deliberative activism” refers to the integration of two ideals of citizen participation: deliberation and activism. While there are strong arguments for bridging the gap between the two ideals, it is equally important to keep what is distinct about deliberative activism because all activism is not (and presumably should not aspire to be) deliberative. In this article, we claim that there are certain ethical and epistemic norms of deliberation that can inform our understanding of “deliberative activism”, thereby help to draw the boundary between activism and deliberative activism. By looking at a particular form of activism—provocative art—that is intuitively antithetical to the deliberative ideal, we argue that simple activism can be differentiated from deliberative activism by considering to what extent activists’ adhere to principles of reasonableness and dialogic responsiveness. Using four cases of controversial, provocative art exhibitions in Sweden that challenges the boundaries of public deliberation we conclude that that it is important to distinguish acts that initiate deliberation from those that are acts of deliberation in themselves. The distinguishing factor must be at the heart of deliberation namely an ethical commitment to dialogue. To the very least, actors must explain their claim as if they were in dialogue.

  • Magnusson, Josefin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Karlsson, Lise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelser av cancerrelaterad smärta: Påverkan på livskvaliteten och vårdens bemötande2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Pain affects most cancer patients, and it is what they fear most about the disease. The pain affects their lives as much as the cancer diagnosis itself.

    Purpose: The purpose of this literature review was to illustrate patients experiences of cancer-related pain and what effects it may have on the quality of life, and to highlight how the healthcare professionals respond to patients’ pain.

    Method: A literature review has been made where eleven scientific articles have been reviewed and analyzed with qualitative content analysis. This generated tree main themes: the experience of the pain, effects on the quality of life, the treatment of care.

    Result: Pain is an individual experience which is difficult to describe. The quality of life of the patients was negatively affected because they were physically, mentally and socially limited. Many were dissatisfied with the care they received and felt that communication was not sufficient. A poor response from caregivers has led to patients’ loss of trust, and inadequate information to loss of hope in being painless.

    Conclusion: Being affected by a cancer diagnosis is hard enough, and at the same time suffer from pain exacerbates the situation. The caregiver has an important role in reducing the patients’ suffering, and by improving the deficiencies, they can make a difference for cancer patients´ suffering from pain.

  • Björkman, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Strömbert Grohs, Linn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Vårdpersonalens erfarenheter av och uppfattningar om stödpersonens roll och betydelse för patienter inom psykiatrisk tvångsvård: En kvalitativ intervjustudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Support persons are an outside resource who are disconnected from the healthcare system and can be assigned to patients who are cared for during involuntary treatment. The support person's work aims to support the patient in an vulnerable period in life through social interaction and encouragement.

    Purpose: To investigate the healthcare staff's experience and opinions about the support person's role and importance for patients in psychiatric compulsory care.

    Methods: Descriptive design with a qualitative approach. As a data collection method, interviews with nine open ended questions were used. A convenience selection was made to achieve eight informants from the healthcare staff at a psychiatric department. As analysis method, content analysis was used. Joyce Travelbees' nursing theory was used as a starting point.

    Results: Overall, the healthcare staff had good knowledge and experience of support persons and their role, despite some variation. The support person was also perceived to have a generally positive and strengthening role for the patient.

    Conclusion: The healthcare staff knew that support persons existed, but there was some uncertainty in what was included in their duties. However, support persons were perceived to have a meaningful role in the patient's well-being. The feeling was that the support person could contribute with a charitable support in a vulnerable situation and that it was of great importance to the patient

  • Westdahl, Josefine
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Ryott, Emelie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Patienters upplevelser av tvångsåtgärder inom psykiatrisk slutenvård: En litteraturstudie2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: People with severe mental illness may need to be cared for in a closed psychiatric ward. In order to improve coercive care, an understanding of these patients' experiences is required.

    Aim: The purpose was to describe patients’experiences of coercive measures in psychiatric inpatient care.

    Method: A literature study with qualitative approach where the results from ten original articles have been analyzed according to a content analysis by Forsberg and Wengström (2015). The theoretical frame of reference selected was Katie Eriksson's nursing theory.

    Result: The result shows that patients have similar experiences of coercive care in the results of all articles. In all results it appears that patients have experienced some form of negative feeling in connection with coercive care. Most of the results show that the patient's integrity, autonomy or human value is being violated in connection with coercion, which in turn leads to deterioration in mental health. A positive experience of coercive care can be achieved when the staff ensures that the patient is well informed, feel trust and is involved, by making the patient feel perceived, heard and respected.

    Conclusion: How patients experience and are affected by coercive care is individual and the experience of care is unique to each patient. The same type of coercive care may in some cases give contradictory results for different patients. However, there are common denominators that can be crucial for the patients' experiences. The nurse has great opportunities to create a positive experience of the care for the patient. Through a humanistic care, which is based on respect, responsiveness and compassion, where the patient becomes involved in their care.

  • Forsberg, Sandra
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Enkvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    HBTQ-personers erfarenheter av bemötande i vården: En litteraturöversikt2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    ABSTRACT

    Background: Through history, homosexuality has been recognized as a psychological or medicational condition. Regardless of present amendments, homosexuality and gender-specific identity may to some extent be seen as tabu. LGBTQ persons generally has an increased risk for developing psychological illnesses, but refrain from seeking care due to previous experiences or fear of poor treatment. The nurse shall generate acceptance and a sense of safety.

    Aim: To compile knowledge of LGBTQ persons´experiences of treatment in health care.

    Method: An overview of 13 original articles. The studies viewed in this overview are performed in varied care units in Sweden, the USA and New Zealand.

    Results: The results point to both strengths and shortcomings of the treatment towards LGBTQ persons in health care. Some informants sensed a heteronormative attitude and ignorance among the healthcare professionals, and in some cases homo- and/or transphobia. Many informants felt uneasy about revealing their sexual orientation to the health care professionals. But the results also show that some healthcare professionals expressed acceptance and neutrality.

    Conclusion: LGBTQ persons experience a sense of heteronormativity and ignorance in regards to treatment in healthcare, but there are healthcare professionals that are educated and accepting.

  • Boström, Johanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Johansson, Sara
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Bemötande kan göra skillnad: Våldsutsatta kvinnors erfarenheter av bemötande och hur de önskar bli bemötta av vårdpersonal2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Violence in close relationships is about all types of violence between relatives and it occurs in all forms of relationships. Every Fourth woman in Sweden is subjected to violence in a close relationship. In 2017, 10 100 cases of violence against women were reported in Close relationships, there are more than 27 cases per day, but about 80 % of cases is never reported to the police. Women who have been subjected to violence in close relationships often suffer from ill-health and there is a correlation between violence and ill-health, which is why it is so important to be able to discover these and offer them help.

    Purpose: The aim was to describe how women subjected to violence in close relationships wish to be met by health professionals Methods: In this qualitative literature, articles were analyzed after Fribergs (2017) method of analysis. Results from each item were aggregated and divided into subcategories and categories.

    Result: Categories that emerged were approach, pay attention to violence and support and help. The most comprehensive finding shows that battered women want health professionals to ask them about violence.

    Conclusion: There is a value in that it appears that all patients are asked for no one to feel convicted or designated. Better knowledge of the subject of all health professionals also contributes to an improvement for the victims of violence who could then be met with a deeper understanding. It is important that the healthcare professional sees the problem even though it is a difficult and sensitive subject. The studies showed that the response is incredibly important for those who are subjected to violence to dare to talk about violence.

  • Axelsson, Linda
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Eriksson Martinez, Olivia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Kvinnors upplevelser av att leva med endometrios - Bemötande och påverkan på livskvalitet2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Aim: The purpose of this study was examine womens’ experience living with a endometriosis diagnosis, the physiological and psychological impacts, as well as their experience and perception of health care encounters.

    Background: Endometriosis is a chronic condition which occurs when cells, naturally found in the endometrium, start to grow elsewhere in the body and form cysts. The characteristic symptoms associated with the condition is chronic pain, infertility and atypical menstruation bleedings.

    Methology: A review of literature research found through two different databases; PubMed and CINAHL. The articles chosen for this study were 12 original research articles, written in English with a qualitative approach.

    Results: Three themes were presented in the study; physiological consequences endometriosis has on women's quality of life, psychological consequences endometriosis hason women’s quality of life, as well as the women’s experiences from health care encounters.The findings show that endometriosis affected different aspects of a woman’s life negativelywith chronic pain, friction on relationships, reduced ability to execute everyday activities and perform at work, reduced psychosocial wellbeing and social isolation.

    Conclusion: The impact on women’s quality of life was greatly reduced due to their inabilityto live fully, related to all the different physiological and psychological consequences that can manifest having endometriosis, as well as bad experiences with healthcare encounters. Women seeking medical care would not get the help and attention they needed in order to live a good and livable life, due to the occurring knowledge gap, the lack of resources and norms of being a woman.

  • Lundvall, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Karlsson, Linda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    HIV-positiva personers upplevelser av stigmatisering och diskriminering i hälso- och sjukvården i Europa och Nordamerika2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: HIV-positive person´s are especially exposed to prejudices from the society which most likely also is reflected in healthcare situations. HIV-positive person´s have an extensive need for medical care and support from healthcare personnel in the process of managing the infection and adherence to the antiviral treatment.

    Aim: To describe HIV-positive person´s experiences of stigmatization and discrimination in healthcare settings and in interaction with healthcare personnel in Europe and north America.

    Method: A literature review with a systematic approach based on 11 qualitative articles. To analyse the articles, coding and thematization was performed.

    Results: Four themes arose: “Offensive experiences in healthcare settings”; “Unequal and inferior care”; “Revelation of HIV status”; “Consequences of stigmatization”.

    Conclusion: HIV-positive person´s experiences stigmatization and discrimination in contact with healthcare in Europe and north America. The discrimination and stigmatization is manifested in different aspects and contexts. A good treatment regimen and regular contact with healthcare is required for a satisfactory treatment outcome. HIV-positive person´s are entitled to a human treatment, just like everyone else, anywhere in the world.

    Keywords: HIV, Stigmatization, discrimination, experience, Healthcare

  • Vestberg, Jessica
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lindblom, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Postoperativ smärta samt upplevd effekt av smärtbehandlingen ur ett patientperspektiv vid planerad höftoperation2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Introduction: Hip arthroplasty is ranked number 11 on the list of the most painful surgical procedures. Developing chronic pain postoperatively is reported to be as high as 10%.

    Aim: Study adult patients' experiences of postoperative pain after planned hip surgery and the patients' experience of pain management.

    Methods: A review of literature based on 10 scientific articles published between 2000 and 2019. Five articles have quantitative approach and five of the articles has qualitative approach.  

    Results: Patients' experiences of postoperative pain after an elective hip operation are individual and described both quantitatively by means of pain estimation scales and qualitatively in their own words. The majority of the studies show that the patients feel sufficiently pain-relieved by the drugs they receive in order to reduce the postoperative pain and in other cases where religious views are recorded, the patients rely on their faith and with the help of their family.

    Conclusion: Postoperative pain after elective hip surgery is a fact. The patients feel pain-relieved or in other cases stand out with the pain for cultural and religious reasons. Patients' involvement during their care period, better follow-up of care after discharge and further research in more effective postoperative pain treatment, are required in the future.

  • Sundkvist, Hillevi
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Business Strategy or Abuse of Dominance: An Analysis of Different Approaches Towards Self-Preferencing Within the Meaning of Article 102 TFEU2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    An undertaking enjoying a dominant position on the internal market has many possibilities to flourish and develop. One way of increasing market power is to expand business activities to downstream markets. An undertaking that is dominant on the upstream market can thus take advantage of its dominance when engaging in business conduct on the downstream market. However, taking advantage of such a position can in some circumstances lead to an infringement of Article 102 TFEU. Recent cases from the EU courts and the EU Commission have, however, demonstrated uncertainties concerning the ways in which the article should be applied.

     

    The purpose of the thesis has been to examine different approaches towards the application of Article 102 TFEU in situations where vertically integrated dominant undertakings are favouring their own downstream operations to the prejudice of competitors. The research question concerns whether there exists a general duty for vertically integrated dominant undertakings not to discriminate in favour of their own downstream operations.

     

    The overall theme of the thesis is the difficulties in drawing a line between legitimate business strategies and abusive business conduct. When intervening against businesses, competition authorities have an important task in balancing the potentially conflicting interests of free competition and counteracting market imperfections. While it is important to encourage business development and innovation, it is also vital to ensure the functioning of the internal market. Discussions concerning these ideas are being held with reference to case law from the EU courts as well as from decisions and statements from the European Commission.

     

    The findings of the thesis show that there has been a noteworthy inconsistency in the application of Article 102 TFEU. A discrepancy in the approaches towards the article has been found, both concerning the main goals of the article as well as the circumstances in which it should be applied. The conclusion is that it is not possible to state that there is a general duty not to discriminate in favour of an undertaking’s own downstream operations. Nevertheless, indications in the direction of such a duty do exist. Finally, the outcome of the analysis suggests that the inconsistency and ambiguities in the law enforcement can result in an infringement of legal certainty.

  • Rodenkirchen, Felicia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Andersson, Sandra
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    När livet tar en vändning: Föräldrars upplevelse av att ha ett cancersjukt barn2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background:Childhood cancer is a recurring and frightening subject. Each year, about 300 children becomes ill in cancer in Sweden. This of course affects the children themselves, but also the parents. To gain more understanding in childhood cancer care, more research is needed on parents' experiences and what was important for them during the disease process.

    Aim:The purpose was to investigate parents' different experiences and feelings of having a child sick in cancer. 

    Method:A literature study was used as method. Ten scientific articles from the databases PubMed and Cinahl were used. Eriksson’s nursing theory was used as theoretical framework of this study.

    Result: A majority of the parents described the first feeling of shock and anxiety when they found out the diagnosis. Many parents felt powerless and inadequate. When their new everyday life changed and adjusted, the focus was only on what happened at that time and nothing could be taken for granted. They were not able to plan the future due to the cancer diagnosis and the long treatment period. The majority of the parents also felt that the nurse had good competence to support and inform about different treatments and with good knowledge of the subject could convey in an empathic and educational way to promote health and good care towards the family.

    Conclusion: When a child gets sick in cancer, it is difficult to know how the child will feel. It is also difficult regardless of knowledge, to know how the parents react when everyone reacts and handles situations differently. It is therefore important that the nurse first of all creates a relationship with the family, and then informs the parents at an early stage about what is happening and will happen in the long, hard time the child will be treated.

  • Płociński, Przemysław
    et al.
    Macios, Maria
    Houghton, Joanna
    Niemiec, Emilia
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland .
    Płocińska, Renata
    Brzostek, Anna
    Słomka, Marcin
    Dziadek, Jarosław
    Young, Douglas
    Dziembowski, Andrzej
    Proteomic and transcriptomic experiments reveal an essential role of RNA degradosome complexes in shaping the transcriptome of Mycobacterium tuberculosis.2019In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, article id gkz251Article in journal (Refereed)
    Abstract [en]

    The phenotypic adjustments of Mycobacterium tuberculosis are commonly inferred from the analysis of transcript abundance. While mechanisms of transcriptional regulation have been extensively analysed in mycobacteria, little is known about mechanisms that shape the transcriptome by regulating RNA decay rates. The aim of the present study is to identify the core components of the RNA degradosome of M. tuberculosis and to analyse their function in RNA metabolism. Using an approach involving cross-linking to 4-thiouridine-labelled RNA, we mapped the mycobacterial RNA-bound proteome and identified degradosome-related enzymes polynucleotide phosphorylase (PNPase), ATP-dependent RNA helicase (RhlE), ribonuclease E (RNase E) and ribonuclease J (RNase J) as major components. We then carried out affinity purification of eGFP-tagged recombinant constructs to identify protein-protein interactions. This identified further interactions with cold-shock proteins and novel KH-domain proteins. Engineering and transcriptional profiling of strains with a reduced level of expression of core degradosome ribonucleases provided evidence of important pleiotropic roles of the enzymes in mycobacterial RNA metabolism highlighting their potential vulnerability as drug targets.

  • Würth, Ines
    et al.
    Univ Stuttgart, Stuttgart Wind Energy, Allmandring 5b, D-70569 Stuttgart, Germany.
    Valldecabres, Laura
    Carl von Ossietzky Univ Oldenburg, ForWind, Inst Phys, Kupkersweg 70, D-26129 Oldenburg, Germany.
    Simon, Elliot
    Tech Univ Denmark, DTU Wind Energy, Riso Campus,Frederiksborgvej 399, DK-4000 Roskilde, Denmark.
    Mohrlen, Corinna
    WEPROG, Willemoesgade 15B, DK-5610 Assens, Denmark.
    Uzunoglu, Bahri
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity. Florida State Univ, Dept Math, Tallahassee, FL 32310 USA.
    Gilbert, Ciaran
    Univ Strathclyde, Dept Elect & Elect Engn, 204 George St, Glasgow G1 1XW, Lanark, Scotland.
    Giebel, Gregor
    Tech Univ Denmark, DTU Wind Energy, Riso Campus,Frederiksborgvej 399, DK-4000 Roskilde, Denmark.
    Schlipf, David
    Flensburg Univ Appl Sci, Wind Energy Technol Inst, Kanzleistr 91-93, D-24943 Flensburg, Germany.
    Kaifel, Anton
    Zentrum Sonnenenergie & Wasserstoff Forsch Baden, Meitnerstr 1, D-70563 Stuttgart, Germany.
    Minute-Scale Forecasting of Wind Power - Results from the Collaborative Workshop of IEA Wind Task 32 and 362019In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 12, no 4, article id 712Article in journal (Refereed)
    Abstract [en]

    The demand for minute-scale forecasts of wind power is continuously increasing with the growing penetration of renewable energy into the power grid, as grid operators need to ensure grid stability in the presence of variable power generation. For this reason, IEA Wind Tasks 32 and 36 together organized a workshop on Very Short-Term Forecasting of Wind Power in 2018 to discuss different approaches for the implementation of minute-scale forecasts into the power industry. IEA Wind is an international platform for the research community and industry. Task 32 tries to identify and mitigate barriers to the use of lidars in wind energy applications, while IEA Wind Task 36 focuses on improving the value of wind energy forecasts to the wind energy industry. The workshop identified three applications that need minute-scale forecasts: (1) wind turbine and wind farm control, (2) power grid balancing, (3) energy trading and ancillary services. The forecasting horizons for these applications range from around 1 s for turbine control to 60 min for energy market and grid control applications. The methods that can be applied to generate minute-scale forecasts rely on upstream data from remote sensing devices such as scanning lidars or radars, or are based on point measurements from met masts, turbines or profiling remote sensing devices. Upstream data needs to be propagated with advection models and point measurements can either be used in statistical time series models or assimilated into physical models. All methods have advantages but also shortcomings. The workshop's main conclusions were that there is a need for further investigations into the minute-scale forecasting methods for different use cases, and a cross-disciplinary exchange of different method experts should be established. Additionally, more efforts should be directed towards enhancing quality and reliability of the input measurement data.

  • Tängmark, Karolina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    #vardeljus: om #metoo-uppropet i Svenska kyrkan2019Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesis
    Abstract [en]

    In the autumn of 2017 the #metoo-movement came to change a whole world. In Sweden, many #metoo-movements started, one of which was #vardeljus. #vardeljus means “Let there be light”, and was a movement of anonymous women in The Church of Sweden. The women wanted to illustrate how women have been sexually harassed in the organization. #vardeljus was also a blog with the same name, where the women shared their stories.

    In this essay, I have studied how the #vardeljus-movement highlighted existing gender structures in The Church of Sweden, and whether or not the movement contributed to an authority displacement. In relation to this, I examined in what way the theory of mediaziation could be useful in the study of these topics.

    In the making of this study, I have mainly relied on the theory of mediaziation as the main theory. In addition I have also benefited from ideas found in the theory of authority displacement as well as from adding a gender perspective. The text material of my choice was the #vardeljus-movement, publicated in the newspaper Kyrkans tidning, and a selection from the associated blog with same name - #vardeljus.

    The method of this study has been a systematic text analysis, wherein I have placed my text material in categories. These categories were power, gender structure, sexually harassment and authority displacement.

    The study found that the #vardeljus-movement illustrated gender structures in The Church of Sweden. These were expressed through sexually harassment, and abuse of power from authorities in the church. Another result of the study was that the movement started a process of an authority displacement, where previously silent stories were heard. In relation to these conclusions, the theory of mediaziation has been used to analyse how these gender structures and authority displacements are presented in the #vardeljus-movement, and how new medias are provided to these conclusions.

  • Stenberg, Lisette
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, The Social Sciences of Religion.
    Religion som orsak till eller lösning på sociala problem.: – En argumentationsanalys av motioner om religiösa friskolor från Socialdemokraterna, Liberalerna och Sverigedemokraterna.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this thesis is to analyze the argumentation used by the Liberals (Liberalerna), Social democrats (Socialdemokraterna) and Sweden democrats (Sverigedemokraterna) in motions regarding religious independent schools in or- der to explore whether they view religion as a cause or as a solution to social problems. The essay focuses on the parliamentary sessions of 2016/17 and 2017/18.

    Three questions were used to guide the study: 1. How do the Liberals, Social democrats and Sweden democrats view religious independent schools - as a solu- tion to, or a cause of social problems? 2. How can we by using Hjelm, El- Menouar and Becker’s development of the theory of religion and social problems understand the political parties descriptions and arguments regarding religious independent schools? 3. What relevance does the results of the study have for the school subject religious education?

    The essay utilizes James A. Beckford’s theory about religion and social prob- lems along with Titus Hjelm, Yasmin El-Menouar and Melanie Becker’s applica- tion of the theory. An argumentative analysis and an abductive approach has been used in this study, which resulted in the finding of six categories of social prob- lems that religious independent schools was deemed to be the cause of: non- democratic values, non-compliance with regulatory documents, integration and parallel societies, unspecified problems, funding, and honor related violence and oppression.

    After analyzing the material, the conclusion was that all of the political parties viewed profiled religion and religious independent schools as a problem. In line with the findings of El-Menouar and Becker the parties expressed a fear for the development of parallel societies, misogyny and honor related violence as well as forcing the pupils to practice a certain religion or be used as a platform for re- cruitment to terror organizations. The results of the study show how religion, mostly Islam, is discussed by three political parties and therefore the results can be used in religious education.

    Keywords: (Independent religious schools, political parties, politics, religion in schools, religion)

  • Public defence: 2019-05-03 09:15 Rudbecksalen, Uppsala
    Gudmundsson, Sanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Translational Research of Mendelian Disorders: Applications of Cutting-Edge Sequencing Techniques and Molecular Tools2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Up to 8% of all live-born children are affected with a congenital disorder. Some are Mendelian disorders of known etiology, but many are of undetermined genetic cause and mechanism, limiting diagnosis and treatment. This project aims to investigate the underlying causes of unresolved Mendelian disorders, and especially syndromes associated with intellectual disability, by using cutting-edge sequencing techniques and molecular tools in a translational setting that intends to directly benefit affected families.

    In Paper I, we report the first keratitis-ichthyosis-deafness syndrome patient presenting with reversion of disease phenotype, a phenomenon known as revertant mosaicism. Third-generation sequencing and a cell assay were used to pin-point the mechanism of the somatic variants giving rise to healthy looking skin in the patient. In Paper II, we describe a novel approach to investigate parental origin, gonadal mosaicism, and estimate recurrence risk of disease in two families. Third-generation sequencing was used for haplotype phasing and detection of low-frequency variants in paternal sperm. The recurrence risk in future offspring in the families affected with Noonan syndrome and Treacher Collins syndrome was determined to be 40% and <0.1% respectively. In Paper III, we describe a novel variant in a patient affected with Cornelia de Lange Syndrome, primarily associated with intellectual disability. The affected gene is linked to an extremely rare form of the syndrome, with limited cases described in the literature, usually associated with mild symptoms. Investigation of rare intellectual disability syndromes was continued in Paper IV, by clinical and genetic characterization of six affected males with a likely pathogenic variant in the TAF1 gene. By creating the first TAF1 orthologue knockout we revealed that taf1 is essential for life and that lack of functional taf1 during embryonic development in zebrafish primarily impacts expression of genes in pathways associated with neurodevelopment. 

    By progressive translational research, using state-of-the-art methodology, this project has illuminated the implication of revertant and gonadal mosaicism in disease (Papers I-II), as well as two extremely rare intellectual disability syndromes (Papers III-IV). In total, five families affected with five different disorders have gained clinical and genetic diagnosis and/or further understanding of prognosis and recurrence risk. The study has led to improved understanding of disease etiology and basic developmental processes, enabling development of new therapies and improved care of future patients.

    List of papers
    1. Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26
    Open this publication in new window or tab >>Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26
    Show others...
    2017 (English)In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 26, no 6, p. 1070-1077Article in journal (Refereed) Published
    Abstract [en]

    Revertant mosaicism(RM) is a naturally occurring phenomenon where the pathogenic effect of a germline mutation is corrected by a second somatic event. Development of healthy-looking skin due to RM has been observed in patients with various inherited skin disorders, but not in connexin-related disease. We aimed to clarify the underlying molecular mechanisms of suspected RM in the skin of a patient with keratitis-ichthyosis-deafness (KID) syndrome. The patient was diagnosed with KID syndrome due to characteristic skin lesions, hearing deficiency and keratitis. Investigation of GJB2 encoding connexin (Cx) 26 revealed heterozygosity for the recurrent de novo germline mutation, c. 148G>A, p. Asp50Asn. At age 20, the patient developed spots of healthy-looking skin that grew in size and number within widespread erythrokeratodermic lesions. Ultradeep sequencing of two healthy-looking skin biopsies identified five somatic nonsynonymous mutations, independently present in cis with the p. Asp50Asn mutation. Functional studies of Cx26 in HeLa cells revealed co-expression of Cx26-Asp50Asn and wild-type Cx26 in gap junction channel plaques. However, Cx26-Asp50Asn with the second-site mutations identified in the patient displayed no formation of gap junction channel plaques. We argue that the second-site mutations independently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative effect of the p. Asp50Asn mutation. To our knowledge, this is the first time RM has been reported to result in the development of healthy-looking skin in a patient with KID syndrome.

    Place, publisher, year, edition, pages
    OXFORD UNIV PRESS, 2017
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-324349 (URN)10.1093/hmg/ddx017 (DOI)000400911000004 ()28158657 (PubMedID)
    Funder
    Swedish Research Council, K2013-57X-22309-3
    Available from: 2017-06-15 Created: 2017-06-15 Last updated: 2019-03-17Bibliographically approved
    2. A novel approach using long-read sequencing and ddPCR to investigate gonadal mosaicism and estimate recurrence risk in two families with developmental disorders
    Open this publication in new window or tab >>A novel approach using long-read sequencing and ddPCR to investigate gonadal mosaicism and estimate recurrence risk in two families with developmental disorders
    Show others...
    2017 (English)In: Prenatal Diagnosis, ISSN 0197-3851, E-ISSN 1097-0223, Vol. 37, no 11, p. 1146-1154Article in journal (Refereed) Published
    Abstract [en]

    Objective

    De novo mutations contribute significantly to severe early-onset genetic disorders. Even if the mutation is apparently de novo, there is a recurrence risk due to parental germ line mosaicism, depending on in which gonadal generation the mutation occurred.

    Methods

    We demonstrate the power of using SMRT sequencing and ddPCR to determine parental origin and allele frequencies of de novo mutations in germ cells in two families whom had undergone assisted reproduction.

    Results

    In the first family, a TCOF1 variant c.3156C>T was identified in the proband with Treacher Collins syndrome. The variant affects splicing and was determined to be of paternal origin. It was present in <1% of the paternal germ cells, suggesting a very low recurrence risk. In the second family, the couple had undergone several unsuccessful pregnancies where a de novo mutation PTPN11 c.923A>C causing Noonan syndrome was identified. The variant was present in 40% of the paternal germ cells suggesting a high recurrence risk.

    Conclusions

    Our findings highlight a successful strategy to identify the parental origin of mutations and to investigate the recurrence risk in couples that have undergone assisted reproduction with an unknown donor or in couples with gonadal mosaicism that will undergo preimplantation genetic diagnosis.

    National Category
    Medical Genetics
    Identifiers
    urn:nbn:se:uu:diva-342916 (URN)10.1002/pd.5156 (DOI)000415897200012 ()28921562 (PubMedID)
    Funder
    Swedish Society for Medical Research (SSMF)
    Available from: 2018-02-26 Created: 2018-02-26 Last updated: 2019-03-17Bibliographically approved
    3. A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 - Review of the literature.
    Open this publication in new window or tab >>A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 - Review of the literature.
    Show others...
    2018 (English)In: European Journal of Medical Genetics, ISSN 1769-7212, E-ISSN 1878-0849, article id S1769-7212(18)30189-7Article in journal (Refereed) Epub ahead of print
    Abstract [en]

    Cornelia de Lange syndrome (CdLS) is a heterogeneous developmental disorder where 70% of clinically diagnosed patients harbor a variant in one of five CdLS associated cohesin proteins. Around 500 variants have been identified to cause CdLS, however only eight different alterations have been identified in the RAD21 gene, encoding the RAD21 cohesin complex component protein that constitute the link between SMC1A and SMC3 within the cohesin ring. We report a 15-month-old boy presenting with developmental delay, distinct CdLS-like facial features, gastrointestinal reflux in early infancy, testis retention, prominent digit pads and diaphragmatic hernia. Exome sequencing revealed a novel RAD21 variant, c.1774_1776del, p.(Gln592del), suggestive of CdLS type 4. Segregation analysis of the two healthy parents confirmed the variant as de novo and bioinformatic analysis predicted the variant as disease-causing. Assessment by in silico structural model predicted that the p.Gln592del variant results in a discontinued contact between RAD21-Lys591 and the SMC1A residues Glu1191 and Glu1192, causing changes in the RAD21-SMC1A interface. In conclusion, we report a patient that expands the clinical description of CdLS type 4 and presents with a novel RAD21 p.(Glu592del) variant that causes a disturbed RAD21-SMC1A interface according to in silco structural modeling.

    Keywords
    Cohesin complex, Cohesin protein, Cohesinopathy, Cornelia de Lange syndrome type 4, RAD21 cohesin complex component
    National Category
    Genetics Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-379362 (URN)10.1016/j.ejmg.2018.08.007 (DOI)30125677 (PubMedID)
    Available from: 2019-03-15 Created: 2019-03-15 Last updated: 2019-03-17
    4. TAF1, associated with intellectual disability in humans, is essential for life and regulates neurodevelopmental processes in zebrafish
    Open this publication in new window or tab >>TAF1, associated with intellectual disability in humans, is essential for life and regulates neurodevelopmental processes in zebrafish
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription factor II D complex that serves a vital function during transcription initiation. Variants of TAF1 have been associated with neurodevelopmental disorders, but TAF1’s molecular function remains elusive. In this study, we present a five-generation family affected with X-linked intellectual disability, co-segregating with a TAF1 c.3568C>T, p.(Arg1190Cys) variant. All affected males presented with intellectual disability and dysmorphic features, while carrier females were asymptomatic and had completely skewed X-chromosome inactivation. We investigated the role of TAF1 and its association to neurodevelopment during early embryogenesis by creating the first complete knockout model of the TAF1 orthologue in zebrafish. A crucial role of human TAF1 during early embryogenesis can be inferred from the model, demonstrating that an intact taf1 is essential for life from early embryonic development. Transcriptome analysis of taf1 zebrafish knockout revealed enrichment of genes in pathways associated with neurodevelopmental processes. In conclusion, we suggest that TAF1 is essential for life and that functional TAF1 is vital for early neurogenesis.

    Keywords
    taf1, intellectual disability, zebrafish
    National Category
    Medical and Health Sciences Genetics
    Research subject
    Medical Genetics
    Identifiers
    urn:nbn:se:uu:diva-379358 (URN)
    Available from: 2019-03-15 Created: 2019-03-15 Last updated: 2019-03-17
  • Höglund, Berit
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
    Larsson, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
    Midwives' work and attitudes towards contraceptive counselling and contraception among women with intellectual disability: focus group interviews in Sweden2019In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 24, no 1, p. 39-44Article in journal (Refereed)
    Abstract [en]

    Objectives: Family planning counselling is an essential part of sexual and reproductive health care; however, health care professionals often fail to offer sexual and reproductive health services to women with intellectual disability (ID), based on a misconception of inactive sexuality. The aims of this study were to gain a deeper understanding of midwives' perceptions of sexual health and contraceptive use of women with ID, and of midwives' practices in providing contraceptive counselling to women with ID.

    Methods: Five focus group interviews were conducted with 19 midwives at five antenatal/family planning clinics in central Sweden between December 2016 and February 2017.

    Results: The findings are presented in a paradigm model comprising the following components: context, causal conditions for women with ID needing contraception, intervening conditions, action and interaction strategies based on the midwives' approach and performance during the consultation, and finally consequences. Midwives strived to enhance informed choice, whenever possible, and tried to maintain a neutral attitude during counselling. They wanted to provide the most suitable contraceptive method balanced against any risk of long-term use and possible side effects. Midwives raised the need for teamwork and inter-professional support to improve health care, security and access to other related services for women with ID.

    Conclusions: Few women with ID request contraceptive counselling, which limits midwives' knowledge, experience and competence. Midwives, therefore, plan consultations carefully and strive to enable women with ID to make informed contraceptive choices. Increased teamwork could be a way to strengthen the role of midwives and thereby improve counselling.

  • Saracevic, Nermina
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Comparison of electricity production between semi-submersible and spar-buoy floating offshore wind turbines2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The paper compares electricity production between the semi-submersible and the spar-buoy floating wind turbine systems under normal, stochastic and extreme wind conditions at Utsira Nord site located on the Norwegian continental shelf in the North Sea. The analysis of complex behavior of the floating wind turbine system and the fluid-structure interaction is performed in aero-servo-hydro-elastic code ASHES.

    The results indicate a slightly better energy performance of the semi-submersible than the spar in all load cases but one. The pitch and heave degrees of freedom are evaluated as the most relevant for the power output. It is shown that pitch and heave platform motions have smaller displacement in the semi-submersible floater than in the spar under average environmental conditions and at the rated wind speed operating range. The simulation also confirmed that the energy yield is very sensitive to the magnitude of the loads: the spar performed best under mild environmental conditions, while the semi-submersible was better under medium environmental conditions. Small difference in energy yield is attributed to the same baseline blade and external controller properties used for both floaters where generator torque was kept constant to limit the power excursions above the rated power.

    The method proposed under this paper has demonstrated that a good approximation of the energy performance of the floating wind turbine system can be performed in a fast and effective manner.

  • Beskow, Anna H.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Uppsala Biobank-the development of a biobank organization in a local, regional, and national setting2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 6-8Article in journal (Refereed)
    Abstract [en]

    A biobank is generally in an international setting considered as a sample collection with linked data. In Sweden we have a lot of sample collections, but the definition of a biobank has changed, and it has become an organization that administrates many sample collections as well as an infrastructure to support research. Uppsala Biobank was started in September 2008 as a joint biobank organization between Uppsala County Council and Uppsala University. At the start there were 138 registered biobanks in Uppsala for these two principals. The decision was to have only one biobank, where all previous biobanks would be transformed to be sample collections. Uppsala Biobank has gone from the wish to centralize biobanking administration to be a research infrastructure, a national model for hospital-integrated biobanking, a support structure for biobanking activities in the health care region, and the local competence center for all biobank issues in Uppsala.

  • Sundström, Johan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Björkelund, Cecilia
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Hansson, Per-Olof
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Koupil, Ilona
    Stockholm Univ, Dept Publ Hlth Sci, Stockholm, Sweden;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Kristenson, Margareta
    Linkoping Univ, Dept Med & Hlth Sci, Div Community Med, Linkoping, Sweden.
    Lagerros, Ylva Trolle
    Karolinska Inst, Dept Med, Unit Clin Epidemiol, Stockholm, Sweden;Karolinska Univ Hosp Huddinge, Dept Endocrinol Metab & Diabet, Huddinge, Sweden.
    Leppert, Jerzy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Lissner, Lauren
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Epidemiol & Social, Gothenburg, Sweden.
    Johansson, Ingegerd
    Umea Univ, Sch Dent, Dept Odontol, Umea, Sweden.
    Ludvigsson, Jonas F.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Orebro Univ, Orebro Univ Hosp, Dept Pediat, Orebro, Sweden.
    Nilsson, Peter M.
    Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden;Lund Univ, Lund, Sweden.
    Olsson, Håkan
    Lund Univ, Dept Clin Sci Canc Epidemiol, Lund, Sweden.
    Pedersen, Nancy L.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Karlsson, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Rosengren, Annika
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.
    Sandin, Sven
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA;Seaver Autism Ctr Res & Treatment Mt Sinai, New York, NY USA.
    Snäckerström, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Stenbeck, Magnus
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Söderberg, Stefan
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden;Umea Univ, Heart Ctr, Umea, Sweden.
    Weiderpass, Elisabete
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Inst Populat Based Canc Res, Dept Res, Canc Registry Norway, Oslo, Norway;Univ Helsinki, Fac Med, Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland;Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway.
    Wanhainen, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Wennberg, Patrik
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Fortier, Isabel
    McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada.
    Heller, Susanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Storgärds, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Svennblad, Bodil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Rationale for a Swedish cohort consortium2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 21-28Article in journal (Refereed)
    Abstract [en]

    We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants' data, better return of funders' investments, and higher benefit to patients and populations. We motivate the proposed infrastructure partly by lessons learned from a pilot study encompassing data from 21 cohorts. We envisage a standing Swedish cohort consortium that would drive development of epidemiological research methods and strengthen the Swedish as well as international epidemiological competence, community, and competitiveness.

  • Liif, Linnea
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Straffrätt och penningtvätt: Ett rättssäkert medel mot smutsig brottslighet? 2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Population-based cardiovascular cohort studies in Uppsala2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 16-20Article in journal (Refereed)
    Abstract [en]

    The first population-based cohort study in Uppsala with the aim to study cardiovascular disease was initiated in 1970 (ULSAM). This cohort of 2300 middle-aged men has since then been followed in a longitudinal fashion for almost 50 years. This study has been followed by the PIVUS study, investigating 1000 men and women at ages 70, 75, and 80. A very detailed examination has also been performed in 500 subjects aged 50 years, the POEM study. In recent years, a high-throughput study conducted in 13000 subjects has also been performed, named EpiHealth. Uppsala also collects data in 5,000 subjects in the nationwide SCAPIS study. Taken together, these cardiovascular-oriented studies constitute a very rich source for cardiovascular epidemiological research in Uppsala. This review summarizes the design of these studies and highlights some of the important results published based on data from these studies.

  • Snäckerström, Tomas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Johansen, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    De-identified linkage of data across separate registers: a proposal for improved protection of personal information in registry-based clinical research2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 29-32Article in journal (Refereed)
    Abstract [en]

    Over the last decades the advent of digital documentation has provided research communities with valuable resources of information for clinical research. To utilize the potential of information about patients, their health care, and its outcome that is already available in different registers, the possibility to cross-reference information from different registers is inevitably required. When performing linkage, we are currently forced to disclose information of participating subjects either to the administration of the other register(s) or to the researcher. Considering the increased concern of issues around personal integrity, this is a limitation that affects the ethical implications of proposed research and that might in the end affect the willingness of subjects to participate in registers. For this reason we propose a different methodology for performing cross-referencing, one that effectively prevents information leakage between the different organizations participating in linking the data. We believe that it is possible to use commonly adopted technologies within the area of data security and encryption to perform linkage without disclosing any sensitive information between different participants. In this paper we demonstrate how common techniques of encryption could be implemented to achieve that and furthermore significantly simplify discovery and feasibility surveying ahead of studies.

  • Nyberg, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Hedman, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Swedish guidelines for registry-based randomized clinical trials2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 33-36Article in journal (Refereed)
    Abstract [en]

    During the last decade Sweden has invested in a national infrastructure for collection of structured clinical data in the form of healthcare registries (in Sweden known as Kvalitetsregister). These data can be combined with other public data using the national personal identifiers that are issued to Swedish citizens. The healthcare registries have an almost complete coverage of Swedish healthcare, and a large network of clinicians is involved in the quality assurance and continuous improvement of healthcare using these registries. Uppsala Clinical Research Center (UCR) has been a technology provider of large-scale national registries and has a strong background in clinical trial management. This effort combines the areas of healthcare registries and clinical trials into a novel way of performing clinical trials to be able to: 1) run clinical trials as an integrated part of normal clinic workflow; and 2) leverage the nationwide network of outcome reporting. This strategy was shown to be successful in the TASTE (Thrombus Aspiration in Myocardial Infarction) study. When TASTE had been published, the New England Journal of Medicine wrote a perspective on the study calling it 'The randomized registry trial-the next disruptive technology in clinical research?' Since then several studies have been conducted in this way with great success. UCR has been appointed, by Clinical Studies Sweden and the Swedish Research Council, to develop the Swedish national guidelines for registry-based randomized clinical trials in order to ensure the possibility for more organizations to run this kind of study. This paper describes key concepts of register-based randomized clinical trials and the development of Swedish national guidelines.

  • Berglund, Lars
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Hambraeus, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Falun Cent Hosp, Dept Cardiol, Falun, Sweden.
    Repeated measures of body mass index and waist circumference in the assessment of mortality risk in patients with myocardial infarction2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 78-82Article in journal (Refereed)
    Abstract [en]

    Aims: Weight loss is recommended for myocardial infarction (MI) patients with overweight or obesity. It has, however, been suggested that obese patients have better prognosis than normal-weight patients have, but also that central obesity is harmful. The aim of this study was to examine associations between repeated measures of body mass index (BMI) and waist circumference (WC), and all-cause mortality.

    Methods and results: A total of 14,224 MI patients aged <75 years in Sweden between the years 2004 and 2013 had measurements of risk factors at hospital discharge. The patients' BMI and WC were recorded in secondary prevention clinics two months and one year after hospital discharge. We collected mortality data up to 8.3 years after the last visit. There were 721 deaths. We used anthropometric measures at the two-month visit and the change from the two-month to the one-year visit. With adjustments for risk factors and the other anthropometric measure the hazard ratio (HR) per standard deviation in a Cox proportional hazard regression model for mortality was 0.64 (95% confidence interval [CI] 0.56-0.74) for BMI and 1.55 (95% CI 1.34-1.79) for WC, and 1.43 (95% CI 1.17-1.74) for a BMI decrease from month two to one year of more than 0.6 kg/m(2). Low BMI and high WC were associated with the highest mortality.

    Conclusion: High WC is harmful regardless of BMI in MI patients. Reduced BMI during the first year after MI is, however, associated with higher mortality, potentially being an indicator of deteriorated health.

  • Jadari, Basim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages, Advanced Studies in Modern Swedish.
    Är röst och kausalitet de hemliga ingredienserna?: Röst och kausalitet i läroböcker i hem- och konsumentkunskap2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna uppsats är att undersöka den språkliga utformningen av två läroböcker med avseende på aspekter som kan antas ha betydelse för andraspråkselevers läsförståelse. Även en jämförelse görs mellan läroböckerna. I analysen undersöks i vilken utsträckning kausalitet framkommer och hur röst kan se ut i läroböckerna. Läroböckerna är avsedda för årskurs 7–9 i ämnet hem- och konsumentkunskap. Resultaten indikerar att de språkliga variablerna röst och kausalitet förekommer i stor utsträckning i de undersökta läroböckerna. Detta kan bidra till en ökad läsförståelse för andraspråkselever. Resultaten indikerar också att läroböckerna generellt sett inte skiljer sig åt i förekomsten av röst och kausalitet.

  • Bäcklund, Alva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Talspråksnära elevtexter i mediesamhället: En kvantitativ studie av förändring av talspråkliga drag i elevtexter2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Meo, Giulia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Ett rättskulturellt skifte i fråga om öppenhet?: - en jämförelse av den moderna offentlighetsprincipen i Sverige, England och Italien2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Soleiman, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems.
    Battery-free Visible Light Sensing2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis, we show that it is possible to design a battery-free light sensing system that can sense and communicate hand gestures while operating fully on harvested power from indoor light. We present two main innovations that push our system to tens of microwatts of power to enable battery-free operation. First, we introduce a novel visible light sensing system that can track variations in light intensity by using a solar cell as a sensor. Solar cells are unlike photodiodes optimized for energy yield in the visible light region and hence do not require any power hungry active components such as an operational amplifier. Furthermore, solar cells can operate under more diverse light conditions as they are not susceptible to saturation under bright light. Second, we devise two ultra-low power communication mechanisms based on radio frequency backscatter to transmit sensor readings at various resolutions without the need of any energy-expensive computational blocks.  We design two battery-free and self-powered hardware prototypes that are based on these two innovations. Our first design utilizes an on-board comparator based circuit to perform a 1-bit digitization of changes in light readings, consuming only sub-microwatt of power for digitization. For our second prototype, we design an analog backscatter mechanism that can map raw sensor readings directly to backscatter transmissions. We demonstrate the feasibility of our designs when sensing significant changes in light intensity caused by shadows from hand gestures, and reconstruct these at a receiving device. Our results demonstrate the ability to sense and communicate various hand gestures at a peak power of 20 microwatts when performing 1-bit digitization, and a mean power of 60 microwatts when performing analog backscatter. Both designs represent orders of magnitude improvement in terms of power consumption over state-of-the-art visible light sensing systems.

  • Andersson, Bo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, German.
    Andreas Gryphius’ Sonette: Eine Interpunktionsgeschichte2018In: Studia Neophilologica, ISSN 0039-3274, E-ISSN 1651-2308, Vol. 90, no Supplement 1, p. 88-113Article in journal (Refereed)
    Abstract [en]

    Die vorliegende Arbeit untersucht die Versionen der 29 Sonette von Andreas Gryphius (1616–1664), die in allen der zu seinen Lebzeiten erschienenen Drucke vorliegen. Drei Aspekte der Gedichte werden im Sinne eines erweiterten Interpunktionsbegriffs berücksichtigt: Die Sonettgraphie und Seitengestaltung, die Interpunktionszeichen und die Hervorhebung durch Großschreibung.

    Die Interpunktion der Sonette wurde ständig revidiert, und es lassen sich bedeutende Unterschiede feststellen. Wer dafür verantwortlich war – der Dichter oder die verschiedenen Buchdrucker – lässt sich mit letzter Sicherheit nicht entscheiden. Doch ist wahrscheinlich, dass den Buchdruckern größere Bedeutung für die Gestaltung der Interpunktion zuzumessen ist als dem Autor selbst.

    Die Analysen machen auch deutlich, wie sich die Unterschiede in der Interpunktion auf die Interpretation der Sonette auswirken.

  • Dahl, Alva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    The Graphic and Grammatical Structure of Written Texts2018In: Studia Neophilologica, ISSN 0039-3274, E-ISSN 1651-2308, Vol. 90, no Supplement 1, p. 24-36Article in journal (Refereed)
    Abstract [en]

    From a linguistic perspective, punctuation relates to grammar and semantics as well as to pragmatics and stylistics. In this paper, I will focus on some grammatical aspects of punctuation in contemporary Swedish, or rather: how awareness of punctuation is necessary for understanding the structure of written texts; but also, how the understanding of punctuation requires an awareness of the partly specific conditions of written language. Punctuation defines entities and hierarchies that may or may not correspond to abstract linguistic categories like phrases and clauses. The graphic word and the graphic sentence, for example, are structural units that in actual written texts follow conventions independent from abstract grammar, as they are defined respectively by word-spacing and initial capital plus final period, exclamation mark or question mark. This makes possible an interesting interplay between grammatical and graphic units. The study is based on a qualitative analysis of the punctuation in three contemporary Swedish novels.

  • Nessen, Thomas
    et al.
    Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Opava, Christina H.
    Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Martin, Cathrin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy.
    Demmelmaier, Ingrid
    Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
    Physiotherapists' management of challenging situations in guiding people with rheumatoid arthritis to health-enhancing physical activity2019In: Physiotherapy Theory and Practice, ISSN 0959-3985, E-ISSN 1532-5040, Vol. 35, no 1, p. 31-39Article in journal (Refereed)
    Abstract [en]

    Objectives: To explore strategies used by physiotherapists (PTs) in guiding people with rheumatoid arthritis to health-enhancing physical activity (HEPA) in a group setting during a 1-year intervention study.

    Methods: Exploratory design with qualitative video analysis performed in three steps. Eleven female PTs were video recorded while leading support group sessions aiming at facilitating HEPA (twice-weekly exercise sessions at public gyms and 150 weekly minutes of moderately intense aerobic physical activity).

    Results: Three categories of challenging situations emerged. They occurred when the HEPA intervention participants reported barriers to performing physical activity, when they neglected to use the planning tool for physical activity as intended in the program, and when they received negative results from physical capacity tests. PTs used different strategies to manage these challenges, with main focus either on information-giving, corresponding to a traditional health professional approach, or utilizing group resources by organizing participation.

    Conclusions: This study provides detailed descriptions of PTs’ clinical behavior in video-recorded sessions. The results imply that motivated PTs can, despite their biomedical and practitioner-focused training, learn to adapt their communication strategies to different situations, altering between traditional information-giving and utilizing group resources by organizing participation.

  • Cars, Thomas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Lindhagen, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    A framework for monitoring of new drugs in Sweden2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 46-50Article in journal (Refereed)
    Abstract [en]

    In order to monitor the net public health benefit of new drugs, especially in the light of recent stepwise approval approaches, there is a need to optimize real-time post-marketing evaluation of new drugs using data collected in routine care. Sweden, with its unique possibilities for observational research, can provide these data. We herein propose a framework for continuous monitoring of the effectiveness, safety, and cost-effectiveness of new drugs, using prospectively determined protocols designed in collaboration between all relevant stakeholders. We believe that this framework can be a useful tool for healthcare authorities and reimbursement agencies in the introduction of new drugs.

  • Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Oldgren, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Latva-Rasku, Aino
    Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Dept Endocrinol, Turku, Finland.
    Johansson, Lars
    Antaros Med AB, Gothenburg, Sweden.
    Lisovskaja, Vera
    AstraZeneca, Gothenburg, Sweden.
    Karlsson, Cecilia
    AstraZeneca, Gothenburg, Sweden.
    Oscarsson, Jan
    AstraZeneca, Gothenburg, Sweden.
    Nuutila, Pirjo
    Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Dept Endocrinol, Turku, Finland.
    Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients - a description of the DAPACARD study2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 59-64Article in journal (Refereed)
    Abstract [en]

    Background: Diabetes increases the risk for cardiovascular (CV) events. It has recently been shown that the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors leads to a reduction in CV outcomes in patients with type 2 diabetes mellitus (T2DM), including mortality and heart failure hospitalization. The exact mechanisms of how SGLT2 inhibitors lead to this CV risk reduction remain incompletely understood. The study of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency and myocardial contractile work in type 2 diabetes patients (DAPACARD) (NCT03387683) explores the possible effects of dapagliflozin, an SGLT2 inhibitor, on cardiac work, metabolism, and biomarker levels.

    Methods: DAPACARD is an international, randomized, double-blind trial that aims to examine the effects of dapagliflozin versus matching placebo in 52 patients with T2DM that are on stable metformin therapy prior to and during the 6 weeks of treatment. The primary efficacy endpoint is change in global longitudinal strain of the left ventricle (GLSLV) measured with magnetic resonance imaging (MRI) between baseline (pre-treatment) and end of study (on-treatment). The secondary endpoint is the corresponding change in myocardial efficiency measured as external left ventricular work divided by total left ventricular work, which is estimated using [11C]-acetate clearance using positron emission tomography (PET).

    Conclusion: The DAPACARD study is an extensive investigation of cardiac function and metabolism, by advanced imaging with PET and MRI, as well as biomarkers, performed in order to further explore how the SGLT2 inhibitor dapagliflozin could influence cardiovascular outcomes in patients with T2DM.

  • Schultzberg, Mårten
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Johansson, Per
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Optimal designs and asymptotic inference2019Report (Other academic)
    Abstract [en]

    Recently an experimental design strategy, called rerandomization, has been proposed as acomplement to traditional blocked designs. The idea of rerandomization is to remove, from consideration, those allocations with large imbalances in observed covariates according to abalance criterion, and then randomize within the set of acceptable allocations. This paper clarifies the concept of an ‘optimal’ rerandomization design for inferences using the mean difference sample estimator, SATE. Based on the Mahalanobis distance criterion for balancing the covariates, we show that standard asymptotic inference to the population, from which the units in the sample are randomly drawn, is possible using only the set of best, or ‘optimal’, allocations.

  • Handels, Ron
    et al.
    Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
    Wimo, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
    Challenges and recommendations for the health-economic evaluation of primary prevention programmes for dementia2019In: Aging & Mental Health, ISSN 1360-7863, E-ISSN 1364-6915, Vol. 23, no 1, p. 53-59Article in journal (Refereed)
    Abstract [en]

    Objective: We aimed to review health-economic evaluations of (hypothetical) intervention programmes for the primary prevention of dementia, and highlight challenges and provide recommendations for future research to estimate its cost-effectiveness.

    Methods: We searched the databases PubMed, MODEM, CEA and NHS for publications on the cost-consequence, -effectiveness, -utility or -benefit analysis of (hypothetical) interventions to reduce the risk of developing dementia for persons without dementia, and described the study characteristics.

    Results: Three publications described the evaluation of a hypothetical risk reduction due to physical activity or a multidomain intervention programme. Two studies reported a reduction of care costs. One study yielded two scenarios of increased care costs and one scenario of reduced care costs. Only one study reported the impact in QALY terms, and found a QALY gain.

    Conclusion: A few studies have evaluated a hypothetical multidomain prevention intervention, and reported that primary dementia prevention is potentially cost-saving or cost-effective. Various challenges remain to evaluate the health-economic impact of prevention interventions, including extrapolation of short-term trial effects, care costs in the dementia-free and life years gained, and accurate representation of usual care. We recommend extensive sensitivity analyses to examine the impact of assumptions regarding these aspects on the outcomes of cost-effectiveness studies.