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  • Persson, Ludwig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Kan alla lära sig bli förskollärare?: En intervjustudie av fyra studenter och en förskollärare2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-02-02 13:00 Lecture hall, Falun
    Källman, Hans-Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Dose Management in Diagnostic Radiology - application of the DICOM imaging standard and a Monte Carlo dose engine for exposure surveillance2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Ionizing radiation is used in diagnostic radiology with a large contribution to the health of the patients. The regulations to limit the detrimental effects, e.g. cancer induction, are based on recommendations from the International Commission on Radiological Protection (ICRP). Epidemiological evidence for radiation induced cancer is expressed as a function of absorbed dose in the irradiated organs. The committee for Biological Effects of Ionizing Radiation has favored the use of Lifetime Attributable Risk, a risk estimator applicable to individuals exposed in medical applications. The imaging in radiology complies with a technical standard that potentiates the retrieval of exposure information that can be used in optimization of patient exposure. The information can also be used as input in organ dose calculations.

    The aims were to apply the benefits of the technical image standard to radiation safety management by automated collection and analysis of exposure data and to adapt a Therapy Planning System (TPS) for radiotherapy to calculate dose for a Computed Tomography (CT) machine.

    An automated workflow for extraction, communication and analysis of exposure data from the image files in the central image archive was defined and implemented at the institution (papers I-II). A source model for Monte Carlo simulation of the CT was developed taking into consideration the energy spectrum of the photons, the spiral movement of the X-ray beam, the beam shaping filter and the tube current modulation (paper III). The source model was used exploring the possibilities to utilize the tissue characterization methods and segmentation tools available in the TPS to devise a strategy to automate organ dose calculations for patients undergoing thorax examinations in a CT (paper IV).

    The exposure data workflow was finalized showing that the technical standard for images could supply a framework for automated assembly and analysis of the data, supporting the local implementation of optimization. The CT was modeled with regard to its irradiation characteristics with uncertainties in the dose calculations below 4%. Dose calculations with the tissue characterization methods available in the TPS deviated by less than 2% from measurements and a strategy for automation of organ dose calculations was devised that could facilitate individual risk estimates in CT.

    List of papers
    1. DICOM Metadata repository for technical information in digital medical images
    Open this publication in new window or tab >>DICOM Metadata repository for technical information in digital medical images
    2009 (English)In: Acta Oncologica, Vol. 48, no 2, 285-288 p.Article in journal (Refereed) Published
    Place, publisher, year, edition, pages
    Taylor & Francis, 2009
    National Category
    Other Physics Topics
    Identifiers
    urn:nbn:se:uu:diva-335529 (URN)
    Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2017-12-08
    2. Automated detection of changes in patient exposure in digital projection radiography using exposure index from DICOM header metadata
    Open this publication in new window or tab >>Automated detection of changes in patient exposure in digital projection radiography using exposure index from DICOM header metadata
    Show others...
    2011 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 50, no 6, 960-965 p.Article in journal (Refereed) Published
    Abstract [en]

    Purpose. Automated collection of image data from DICOM headers enables monitoring of patient dose and image quality parameters. Manual monitoring is time consuming, owing to the large number of exposure scenarios, thus automated methods for monitoring needs to be investigated. The aim of the present work was to develop and optimise such a method. Material and methods. Exposure index values from digital systems in projection radiography were collected over a period of five years, representing data from 1.2 million projection images. The exposure index values were converted to detector dose and an automated method for detection of sustained level shifts in the resulting detector dose time series was applied using the statistical analysis tool R. The method combined handling of outliers, filtering and estimation of variation in combination with two different statistical rank tests for level shift detection. A set of 304 time series representing central body parts was selected and the level shift detection method was optimised using level shifts identified by ocular evaluation as the gold standard. Results. Two hundred and eighty-one level changes were identified that were deemed in need of further investigation. The majority of these changes were abrupt. The sensitivity and specificity of the optimised and automated detection method concerning the ocular evaluation were 0.870 and 0.997, respectively, for detected abrupt changes. Conclusions. An automated analysis of exposure index values, with the purpose of detecting changes in exposure, can be performed using the R software in combination with a DICOM header metadata repository containing the exposure index values from the images. The routine described has good sensitivity and acceptable specificity for a wide range of central body part projections and can be optimised for more specialised purposes.

    National Category
    Radiology, Nuclear Medicine and Medical Imaging
    Identifiers
    urn:nbn:se:uu:diva-156931 (URN)10.3109/0284186X.2011.579622 (DOI)000292841500029 ()
    Available from: 2011-08-20 Created: 2011-08-11 Last updated: 2017-12-08Bibliographically approved
    3. Source modeling for Monte Carlo dose calculation of CT examinations with a radiotherapy treatment planning system
    Open this publication in new window or tab >>Source modeling for Monte Carlo dose calculation of CT examinations with a radiotherapy treatment planning system
    Show others...
    2016 (English)In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 43, no 11, 6118-6128 p.Article in journal (Refereed) Published
    Abstract [en]

    Purpose: Radiation dose to patients undergoing examinations with Multislice Computed Tomography (MSCT) as well as Cone Beam Computed Tomography (CBCT) is a matter of concern. Risk management could benefit from efficient replace rational dose calculation tools. The paper aims to verify MSCT dose calculations using a Treatment Planning System (TPS) for radiotherapy and to evaluate four different variations of bow-tie filter characterizations for the beam model used in the dose calculations. Methods: A TPS (RayStation (TM), RaySearch Laboratories, Stockholm, Sweden) was configured to calculate dose from a MSCT (GE Healthcare, Wauwatosa, WI, USA). The x-ray beam was characterized in a stationary position the by measurements of the Half-Value Layer (HVL) in aluminum and kerma along the principal axes of the isocenter plane perpendicular to the beam. A Monte Carlo source model for the dose calculation was applied with four different variations on the beam-shaping bow-tie filter, taking into account the different degrees of HVL information but reconstructing the measured kerma distribution after the bow-tie filter by adjusting the photon sampling function. The resulting dose calculations were verified by comparison with measurements in solid water as well as in an anthropomorphic phantom. Results: The calculated depth dose in solid water as well as the relative dose profiles was in agreement with the corresponding measured values. Doses calculated in the anthropomorphic phantom in the range 26-55 mGy agreed with the corresponding thermo luminescence dosimeter (TLD) measurements. Deviations between measurements and calculations were of the order of the measurement uncertainties. There was no significant difference between the different variations on the bow-tie filter modeling. Conclusions: Under the assumption that the calculated kerma after the bow-tie filter replicates the measured kerma, the central specification of the HVL of the x-ray beam together with the kerma distribution can be used to characterize the beam. Thus, within the limits of the study, a flat bow-tie filter with an HVL specified by the vendor suffices to calculate the dose distribution. The TPS could be successfully configured to replicate the beam movement and intensity modulation of a spiral scan with dose modulation, on the basis of the specifications available in the metadata of the digital images and the log file of the CT.

    Keyword
    radiation exposure, radiation oncology, tomography, x-ray computed, Monte Carlo method, risk management
    National Category
    Radiology, Nuclear Medicine and Medical Imaging
    Identifiers
    urn:nbn:se:uu:diva-310771 (URN)10.1118/1.4965043 (DOI)000387007500033 ()27806588 (PubMedID)
    Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2017-12-08Bibliographically approved
    4. Towards automated and personalized organ dose determination in CT examinations – influence of tissue data representations for Monte Carlo dose calculation with a Therapy Planning System
    Open this publication in new window or tab >>Towards automated and personalized organ dose determination in CT examinations – influence of tissue data representations for Monte Carlo dose calculation with a Therapy Planning System
    (English)In: Medical physics (Lancaster), ISSN 0094-2405Article in journal (Refereed) Submitted
    National Category
    Other Physics Topics
    Identifiers
    urn:nbn:se:uu:diva-335555 (URN)
    Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2017-12-08
  • Ekblad, Emmy
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Eriksson, Miriam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Omvårdnad vid barnmisshandel via sjukvårdsinsatser: En systematisk litteraturstudie2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Medical child abuse occurs when an adult caretaker induces, fabricates, or

    describes non-existing symptoms in a child. Aim: To investigate the conditions that exist in the medical setting for the child to receive the best care in cases where the caretaker exposes the child to medical-child-abuse. The aim was also to investigate what kind of knowledge required in healthcare to handle medical child abuse and investigate if there are any cultural differences. Methods: Systematic review. 13 articles were included, seven qualitative, four case studies and two quantitative. Results: Analyzed data show consistency in symptoms in children who have been exposed to medical child abuse. Correlation between mother’s mental health and medical-child-abuse was found. Attachment representation and mother-child-relationship matters, as well as the family situation and socioeconomic background. The mothers have a huge need for attention and confirmation. No cultural differences could be found. Screening instrument and video surveillance was important diagnostic tools. Multidisciplinary teamwork and cooperation was important to provide good care for the child. The nurse’s competence, intuition and experience had a great impact on the care. Conclusion: In order to provide the best care for children in cases where the parent / guardian exposes the child to medical-child-abuse certain conditions are required. Knowledge about symptoms and the interaction between mother and child are required. A national system for medical records and screening would lead to more cases of medical child abuse being discovered. It would also give greater understanding of the existence of this type of abuse. More research and cooperation is needed on and around children exposed to medical- child-abuse. 

  • Moa, Larsson
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Emelie, Nilsson
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Assisterad befruktning för ensamstående kvinnor: En kartläggning av vårdrutiner på landets fertilitetskliniker2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Den 1 april 2016 blev det enligt lag möjligt för ensamstående kvinnor att få assisterad befruktning i Sverige. Tidigare reste kvinnor till andra länder för att få hjälp. Den nya lagändringen tyder på förändrade normer och ökad acceptans för alternativa föräldraskap. Syfte: var att kartlägga vårdrutiner på svenska fertilitetskliniker. 

    Metod: Kvantitativ deskriptiv design med postenkätstudie som datainsamlingsmetod. Urvalet var en totalundersökning där samtliga fertilitetskliniker i Sverige som erbjöd assisterad befruktning inkluderades, varav universitetssjukhus (n=6) och privata fertilitetskliniker (n=11). 

    Resultat: Samtliga universitetssjukhus och nio privata fertilitetsklinikerna erbjuder ensamstående kvinnor assisterad befruktning. Den genomsnittliga väntetiden på universitetssjukhusen var 13,5 månader, anledningarna till de långa väntetiderna är brist på spermiedonatorer, ekonomiska skäl, brist på läkare och kuratorer samt lokaler. De privata fertilitetsklinikerna har en genomsnittlig väntetid på 2,6 månader. Totalt är det drygt 900 ensamstående kvinnor som står i kö för utredning och behandling i Sverige. Universitetssjukhusen har fler kvinnor som står i kö. De privata fertilitetsklinikerna har utfört fler utredningar och behandlingar. Lokala riktlinjer eller dokument för vårdrutiner gällande assisterad befruktning av ensamstående kvinnor saknas. Universitetssjukhusen följer de nationella rekommendationerna men de privata fertilitetsklinikerna avviker gällande åldersgränser och antal behandlingar. 

    Slutsats: Alla fertilitetskliniker, utom två privata erbjuder assisterad befruktning för ensamstående kvinnor i Sverige. Det finns brister och förhållanden som behöver åtgärdas för att uppnå en jämlik vård över landet. Många ensamstående kvinnor önskar assisterad befruktning, vilket visar att det finns ett stort antal kvinnor som har behov av att bli förälder på egen hand utan närvaro av en fast partner. 

  • Gustavsson, Sverker
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Skilj på liberal och libertär!2017In: Respons : recensionstidskrift för humaniora & samhällsvetenskap, ISSN 2001-2292, ISSN 2201-2292, Vol. 6, no 6, 14-15 p.Article in journal (Other (popular science, discussion, etc.))
  • Holmén, Janne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History. Samtidshistoriska institutet, Södertörns högskola, Stockholm, Sweden.
    Mapping Historical Consciousness: Mental Maps of Time and Space among Secondary School Students from Ten Locations around the Baltic and Mediterranean Seas2017In: Journal of Autonomy and Security Studies, ISSN 2489-4265, Vol. 1, no 1, 46-75 p.Article in journal (Refereed)
    Abstract [en]

    The article investigates the temporal and spatial structure of historical consciousness among secondary school students from ten locations around the Baltic and Mediterranean seas. It examines what eras and spaces in history that are important to the students, and discusses how the mental maps of individuals at a certain location are affected by geopolitics and interpretations of historical experiences.

    The results are mainly based upon one open survey question: Write down the name of as many important historical figures as possible within five minutes. Psychological theories of memory are used in order to explain how such simple memory retrieval can be used in studies of historical consciousness. The data from the survey is presented in the form of maps, using techniques of mental mapping developed by geographers,

    The empirical investigation reveals three categories of historical consciousness: national, found in Italy and Morocco, Americanized, found in Sweden, and multipolar, found in Estonia and on Åland and Malta. The article argues that each of the three strands of historical consciousness is linked to specific historical and geopolitical circumstances.

  • D'Elia, Domenica
    et al.
    Institute for Biomedical Technologies, CNR, Via Amendola 122/D, 70126 Bari, Italy.
    Gisel, Andreas
    Institute for Biomedical Technologies, CNR, Via Amendola 122/D, 70126 Bari, Italy.
    Eriksson, Nils-Einar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, The Linnaeus Centre for Bioinformatics.
    Kossida, Sophia
    Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
    Mattila, Kimmo
    CSC – IT Center for Science Ltd., Keilaranta 14, 02100 Espoo, Finland.
    Klucar, Lubos
    Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 84551 Bratislava, Slovakia.
    Bongcam-Rudloff, Erik
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 75024 Uppsala, Sweden.
    The 20th anniversary of EMBnet: 20 years of bioinformatics for the Life Sciences community2009In: BMC Bioinformatics, ISSN 1471-2105, E-ISSN 1471-2105, Vol. 10, no Suppl. 6, S1- p.Article in journal (Refereed)
    Abstract [en]

    The EMBnet Conference 2008, focusing on 'Leading Applications and Technologies in Bioinformatics', was organized by the European Molecular Biology network (EMBnet) to celebrate its 20th anniversary. Since its foundation in 1988, EMBnet has been working to promote collaborative development of bioinformatics services and tools to serve the European community of molecular biology laboratories. This conference was the first meeting organized by the network that was open to the international scientific community outside EMBnet. The conference covered a broad range of research topics in bioinformatics with a main focus on new achievements and trends in emerging technologies supporting genomics, transcriptomics and proteomics analyses such as high-throughput sequencing and data managing, text and data-mining, ontologies and Grid technologies. Papers selected for publication, in this supplement to BMC Bioinformatics, cover a broad range of the topics treated, providing also an overview of the main bioinformatics research fields that the EMBnet community is involved in.

  • Amaral, Marcelo Francisco
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Integration of Dynamic Line Rating within a Risk-Based Security Assessment Framework2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The following work applies Dynamic Line Rating (DLR) to a Risk-Based SecurityAssessment (RBSA) methodology with the ultimate goal to perform day-aheadforecastanalysis. DLR quantifies transmission capacities of overhead lines whilst beingdependent on ambient conditions. It takes into account variations in its surroundings,therefore making DLR less conservative compared to the traditional worst-casescenario oriented Static Line Rating (SLR). Applying DLR to overhead transmissionlines (OHLs) entails different spans of potential benefits for solving grid exhaustionproblems due to crescent electrical consumptions.The RBSA methodology allows for the assessment of security of power systemoperations in a future state under uncertainties that arise from contingencies andforecast errors, e.g., loads or renewable infeeds. The methodology models inputuncertainty with a copula integration with Monte-Carlo (MC) sampling framework.Several case-studies are executed for the assessment of DLR impacts, especiallycomparing them to SLR through the evaluation of system risk. Two case-studies areperformed for a specific time of the day, one analyzing risk and ratings and the otherconcerning system impacts upon evolution of system forecast uncertainty (SFU) tovalues above day-ahead analysis usual intervals. The following two cases are theextensions to 24 point analyses, with the same goal, although more generalized. Thefinal case study analyzes the economical impact of DLR applications and assesses analternative system configuration behavior. This alternative setup is in constantcomparison with the original configuration used throughout the project, advantagesand drawbacks of both configurations are discussed. Finally, success of thisintegration and assessment of impact and methodology is addressed in the end.

  • Atesok, Kivanc
    et al.
    University of Alabama at Birmingham, Birmingham, USA.
    Tanaka, Nobuhiro
    Hiroshima University, Hiroshima, Japan.
    O'Brien, Andrew
    Royal Victoria Hospital and Royal Belfast Hospital for Sick Children, Belfast, UK.
    Robinson, Yohan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Pang, Dachling
    University of California, Davis, USA; Kaiser Permanente Hospitals, Oakland, USA; Great Ormond Street Hospital For Children, London, UK.
    Deinlein, Donald
    University of Alabama at Birmingham, Birmingham, USA.
    Manoharan, Sakthivel Rajaram
    University of Alabama at Birmingham, Birmingham, USA.
    Pittman, Jason
    University of Alabama at Birmingham, Birmingham, USA.
    Theiss, Steven
    University of Alabama at Birmingham, Birmingham, USA.
    Posttraumatic Spinal Cord Injury without Radiographic Abnormality2018In: Advances in Orthopedics, ISSN 2090-3464, E-ISSN 2090-3472, Vol. 2018, 7060654Article, review/survey (Refereed)
    Abstract [en]

    “Spinal Cord Injury without Radiographic Abnormality” (SCIWORA) is a term that denotes objective clinical signs of posttraumatic spinal cord injury without evidence of fracture or malalignment on plain radiographs and computed tomography (CT) of the spine. SCIWORA is most commonly seen in children with a predilection for the cervical spinal cord due to the increased mobility of the cervical spine, the inherent ligamentous laxity, and the large head-to-body ratio during childhood. However, SCIWORA can also be seen in adults and, in rare cases, the thoracolumbar spinal cord can be affected too. Magnetic resonance imaging (MRI) has become a valuable diagnostic tool in patients with SCIWORA because of its superior ability to identify soft tissue lesions such as cord edema, hematomas and transections, and discoligamentous injuries that may not be visualized in plain radiographs and CT. The mainstay of treatment in patients with SCIWORA is nonoperative management including steroid therapy, immobilization, and avoidance of activities that may increase the risk of exacerbation or recurrent injury. Although the role of operative treatment in SCIWORA can be controversial, surgical alternatives such as decompression and fusion should be considered in selected patients with clinical and MRI evidence of persistent spinal cord compression and instability.

  • Wallensteen, Peter
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Nordquist, Kjell-Åke
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Hagelin, Björn
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Melander, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Towards a security community in the Baltic region: Patterns of Peace and Conflict1994Book (Other academic)
  • Al-Mashhadi, Ammar Nadhom Farman
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
    Checa, Antonio
    Karolinska Institute.
    Wåhlin, Nils
    Karolinska Institute.
    Nevéus, Tryggve
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Fossum, Magdalena
    Karolinska institute.
    Wheelock, Craig E.
    Karolinska Institute.
    Karanikas, Birgitta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
    Stenberg, Arne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
    Persson, A. Erik G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Carlström, Mattias
    Karolinska Institute.
    Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children2017In: Pediatric nephrology (Berlin, West), ISSN 0931-041X, E-ISSN 1432-198XArticle in journal (Refereed)
    Abstract [en]

    Objective Recent clinical studies have suggested an increased risk of elevated arterial pressure in patients with hydronephrosis. Animals with experimentally induced hydronephrosis develop hypertension, which is correlated to the degree of obstruction and increased oxidative stress. In this prospective study we investigated changes in arterial pressure, oxidative stress, and nitric oxide (NO) homeostasis following correction of hydronephrosis.

    Methods Ambulatory arterial pressure (24 h) was monitored in pediatric patients with hydronephrosis (n = 15) before and after surgical correction, and the measurements were compared with arterial pressure measurements in two control groups, i.e. healthy controls (n = 8) and operated controls (n = 8). Markers of oxidative stress and NO homeostasis were analyzed in matched urine and plasma samples.

    Results The preoperative mean arterial pressure was significantly higher in hydronephrotic patients [83 mmHg; 95% confidence interval (CI) 80–88 mmHg] than in healthy controls (74 mmHg; 95% CI 68–80 mmHg; p < 0.05), and surgical correction of ureteral obstruction reduced arterial pressure (76 mmHg; 95% CI 74–79 mmHg; p < 0.05). Markers of oxidative stress (i.e., 11- dehydroTXB2, PGF2α, 8-iso-PGF2α, 8,12-iso-iPF2α-VI) were significantly increased (p < 0.05) in patients with hydronephrosis compared with both control groups, and these were reduced following surgery (p < 0.05). Interestingly, there was a trend for increased NO synthase activity and signaling in hydronephrosis, which may indicate compensatory mechanism(s).

    Conclusion This study demonstrates increased arterial pressure and oxidative stress in children with hydronephrosis compared with healthy controls, which can be restored to normal levels by surgical correction of the obstruction. Once reference data on ambulatory blood pressure in this young age group become available, we hope cut-off values can be defined for deciding whether or not to correct hydronephrosis surgically.

    Keywords Blood pressure . Hydronephrosis . Hypertension . Nitric oxide . Oxidative stress . Ureteral obstruction 

  • Melander, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Justice or Peace: A Statistical Study of the Relationship between Amnesties and Durable Peace2009Report (Other academic)
  • Donovan, Stephen
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of English.
    The American Serialization of Lord Jim2017In: Journal of European Periodical Studies, ISSN 1684-0186, E-ISSN 1541-4329, Vol. 2, no 2, 3-24 p.Article in journal (Refereed)
    Abstract [en]

    This essay presents the discovery of the American serialization of Joseph Conrad’s Lord Jim in New York’s Evening Telegramin 1903. This ‘lost’ serialization, it argues, invites a new perspective on Conrad’s early career by foregrounding the role of newspaper serialization and syndication in establishing his literary standing. After surveying the principal differences in the respective reading experiences of the periodical versus the book, it concludes by proposing that the prominence of women among Conrad’s first audiences requires us to reassess the basis for his success in North America and elsewhere.

  • Hossain, Asha
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Ayoub, Meriem
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Individanpassning för motivation -Ur ett lärarperspektiv2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie handlar om individanpassning för omotiverade elever i både undervisning och skolan ur ett lärarperspektiv.

    Lärare jobbar med att anpassa undervisningen på bästa möjliga sätt som gynnar eleverna. De använder sig av olika metoder till att anpassa undervisningen och försöka motivera de elever som är omotiverade. Skolan gör även sitt jobb genom att tillämpa olika typer av resurser de har tillgång till. Detta görs för att hjälpa eleverna med extra behov och anpassningar att klara kunskapskraven och andra mål. Denna studie för fram lärarnas resonemang kring omotiverade elever och individanpassning, vilka metoder de använde sig av och om det finns en gräns för att anpassa undervisningen och i så fall vart den tog stopp. Data samlades in genom utskickade elektroniska enkäter till klass- och ämneslärare från förskoleklasser till och med årskurs 6, både i skolor och i lärargrupper på sociala medier. Totalt fick vi in 69 besvarade enkäter.

    Resultatet visade att lärarna väljer att variera sin undervisning med olika typer av arbetssätt, till exempel par- eller grupparbeten, för att stimulera de omotiverade eleverna. Berömma de omotiverade eleverna är också något som lärarna gjorde för att indikera att eleven gjort bra ifrån sig vilket i sin tur fick omotiverade eleverna att drivas framåt.

    De flesta lärare upplevde att individanpassningen gick utöver tiden för planering. Därför kände vissa lärare att det skulle vara underlättande med gränser för individanpassning. Alltså att det skulle kunna finnas riktlinjer för hur mycket en lärare kan individanpassa för sin omotiverade elev. Lärarna upplevde sig göra sitt bästa för att motivera hela sin klass och även anpassa för eleverna med extra behov. Därmed räckte ibland inte skolans resurser till och därför vände lärarna sig till sina kollegor eller skolledningen för att få stöd.

  • Kaltsas, Gregory
    et al.
    Univ Athens, Dept Pathophysiol, Endocrine Unit.
    Caplin, Martyn
    Royal Free Hosp, Neuroendocrine Tumour Unit.
    Davies, Philippa
    Royal Free Hosp, Neuroendocrine Tumour Unit.
    Ferone, Diego
    Univ Genoa, IRCCS AOU San Martino IST, Dept Internal Med & Med Specialties DiMI, Endocrinol Unit, CEBR.
    Garcia-Carbonero, Rocio
    Hosp Univ Doce Octubre, Med Oncol Dept.
    Grozinsky-Glasberg, Simona
    Hadassah Hebrew Univ, Med Ctr, Endocrinol & Metab Serv, Neuroendocrine Unit.
    Hoersch, Dieter
    Gastroenterol & Endocrinol Ctr Neuroendocrine Tum.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Kianmanesh, Reza
    Robert Debre Hosp, Dept Digest & Endocrine Surg.
    Kos-Kudla, Beata
    Med Univ Silesia, Div Endocrinol, Dept Pathophysiol & Endocrinol.
    Pavel, Marianne
    Charite Univ Med Berlin, Campus Virchow Klinikum, Dept Hepatol & Gastroenterol.
    Rinke, Anja
    UKGM Marburg, Dept Gastroenterol.;Philipps Univ Marburg.
    Falconi, Massimo
    Univ Vita & Salute, Osped San Raffaele, Pancreas Translat & Clin Res Ctr, Chirurg Pancreas.
    de Herder, Wouter W.
    Erasmus MC Canc Ctr, ENETS Ctr Excellence.
    ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors2017In: Neuroendocrinology, ISSN 0028-3835, E-ISSN 1423-0194, Vol. 105, no 3, 245-254 p.Article in journal (Refereed)
    Abstract [en]

    Neuroendocrine tumors of the small intestine are the most common causes of the carcinoid syndrome. Carcinoid heart disease occurs in more than half of the patients with the carcinoid syndrome. Patients with carcinoid heart disease who need to undergo surgery should also undergo preoperative evaluation by an expert cardiologist. Treatment with longacting somatostatin analogs aims at controlling the excessive hormonal output and symptoms related to the carcinoid syndrome and at preventing a carcinoid crisis during interventions. Patients with a gastrinoma require pre- and postoperative treatment with high doses of proton pump inhibitors. Patients with a glucagonoma require somatostatin analog treatment and nutritional supplementation. Patients with a VIPoma also require somatostatin analog treatment and intravenous fluid and electrolyte therapy. Insulinoma patients generally require intravenous glucose infusion prior to operation. In patients with localized operable insulinoma, somatostatin analog infusion should only be considered after the effect of this therapy has been electively studied.

  • Espinosa-Garcia, W. F.
    et al.
    Universidad de San Buenaventura-Medellín, Facultad de Ingenierías, Grupo de Investigación en Modelamiento y Simulación Computacional; Universidad de Antioquia UdeA, Instituto de Física.
    Osorio-Guillen, J. M.
    Universidad de Antioquia UdeA, Instituto de Física.
    Araujo, Carlos Moyses
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Dimension-dependent band alignment and excitonic effects in graphitic carbon nitride: a many-body perturbation and time-dependent density functional theory study2017In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, no 71, 44997-45002 p.Article in journal (Refereed)
    Abstract [en]

    First-principles many-body theory and time-dependent density functional theory were used to study the dimension effects on the band alignment and optical properties of s-triazine and graphitic C3N4. The inclusion of quasiparticle corrections is very important to describe the quantum confinement and the enhancement of the electron-electron (e-e) interaction. The calculated quasiparticle gaps range from 4.0 eV (monolayer) to 3.21 eV (tetralayer). The position of the valence band maxima is found to be almost constant, whereas the conduction band minima show a strong quantum confinement effect with a variation of similar to 0.7 eV respective to the bulk structure. The calculated frequency-dependent imaginary part of the dielectric function using the Bethe-Salpeter equation shows prominent excitonic effects, where there is a strong redistribution of the spectral weight to lower photon energies in the ultraviolet frequencies where the major part of the absorption occurs. On the other hand, a less intense excitonic absorption in the visible region is due to light polarization perpendicular to the surface plane. In contrast, time-dependent density functional theory also shows a redistribution of the spectral weight in the ultraviolet but it fails to describe the excitonic features in the visible region.

  • Ma, Zuheng
    et al.
    Karolinska Institutet, Karolinska University Hospital, Department of Molecular Medicine and Surgery.
    Bjorklund, Anneli
    Karolinska Institutet, Karolinska University Hospital, Department of Molecular Medicine and Surgery.
    Islam, Md. Shahidul
    Karolinska Institutet, Research Center, Södersjukhuset, Department of Clinical Science and Education; Uppsala University Hospital, Department of Emergency Care and Internal Medicine.
    A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans2017In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, 5131785Article in journal (Refereed)
    Abstract [en]

    Pancreatic beta-cells express several ion channels of the transient receptor potential family, which play important roles in mediating the stimulus-secretion coupling. One of these channels, the TRPM4 is a Ca2+-activated monovalent cation channel. This channel is inhibited by 9-phenanthrol, which also inhibits the TMEM16a Cl- channel, and activates the Ca2+-activated K+ channel, K(ca)3.1. The net effects of ion-channel modulation by 9-phenantherol on the insulin secretion remain unclear. We tested the effects of 9-phenanthrol on glucose-and GLP-1-induced insulin secretion from isolated rat islets in static incubations. When applied to the islets in the presence of 3.3mM glucose, 9-phenanthrol caused a small increase in insulin secretion (similar to 7% of the insulin secretion stimulated by 10mM glucose). 10 mu M 9-phenanthrol did not inhibit glucose-or GLP-1-induced insulin secretion. 20 mu M and 30 mu M 9-phenanthrol inhibited glucose-induced insulin secretion by similar to 80% and similar to 85%, respectively. Inhibition of the GLP-1-induced insulin secretion by 20 mu M and 30 mu M 9-phenanthrol was 65% and 94%, respectively. Our study shows that the major effect of 9-phenanthrol on the islets is a strong inhibition of insulin secretion, and we speculate that compounds related to 9-phenanthrol may be potentially useful in treating the pancreatogenous hyperinsulinemic hypoglycemia syndromes.

  • Barbosa, R. N.
    et al.
    Westerdijk Fungal Biodiversity Institute; Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Leong, S. L.
    Swedish University of Agricultural Sciences, Department of Molecular Sciences.
    Vinnere, Olga
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab. Swedish University of Agricultural Sciences, Department of Molecular Sciences.
    Chen, A. J.
    Westerdijk Fungal Biodiversity Institute; Chinese Academy of Medical Sciences, Institute of Medicinal Plant Development; Peking Union Medical College.
    Souza-Motta, C. M.
    Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Frisvad, J. C.
    Technical University of Denmark, Department of Biotechnology and Biomedicine.
    Samson, R. A.
    Westerdijk Fungal Biodiversity Institute.
    Oliveira, N. T.
    Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Houbraken, J.
    Westerdijk Fungal Biodiversity Institute.
    Phylogenetic analysis of Monascus and new species from honey, pollen and nests of stingless bees2017In: Studies in mycology, ISSN 0166-0616, E-ISSN 1872-9797, no 86, 29-51 p.Article in journal (Refereed)
    Abstract [en]

    The genus Monascus was described by van Tieghem (1884) to accommodate M. ruber and M. mucoroides, two species with non-ostiolate ascomata. Species delimitation in the genus is still mainly based on phenotypic characters, and taxonomic studies that include sequence data are limited. The genus is of economic importance. Species are used in fermented Asian foods as food colourants (e.g. 'red rice' (ang-kak, angka)) and found as spoilage organisms, and recently Monascus was found to be essential in the lifecycle of stingless bees. In this study, a polyphasic approach was applied combining morphological characters, ITS, LSU, beta-tubulin, calmodulin and RNA polymerase II second largest subunit sequences and extrolite data, to delimit species and to study phylogenetic relationships in Monascus. Furthermore, 30 Monascus isolates from honey, pollen and nests of stingless bees in Brazil were included. Based on this polyphasic approach, the genus Monascus is resolved in nine species, including three new species associated with stingless bees (M. flavipigmentosus sp. nov., M. mellicola sp. nov., M. recifensis sp. nov., M. argentinensis, M. floridanus, M. lunisporas, M. pallens, M. purpureus, M. ruber), and split in two new sections (section Floridani sect. nov., section Rubri sect. nov.). Phylogenetic analysis showed that the xerophile Monascus eremophilus does not belong in Monascus and monophyly in Monascus is restored with the transfer of M. eremophilus to Penicillium (P. eremophilum comb. nov.). A list of accepted and excluded Monascus and Basipetospora species is given, together with information on (ex-)types cultures and barcode sequence data.

  • Khalifeh, Rozan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology.
    Women refugees are not only vulnerable, they are resilient too!: Does the resilience of women built the reslience of their families?2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • Gignoux, Suzanne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology. Université de Strasbourg, Institut de Traducteurs, d'Interprètes et de Relations Internationales.
    "Why not let us?": Recognition and participation of samebys in a national park project: The case of Vålådalen-Sylarna-Helags2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    With different interests at stake, conservation is at the centre of power relations and negotiations over how best to manage a landscape, and is thus a potential source of conflicts, not only about how to manage the land, but also more importantly about what is just. In 2008 Sweden's National Park Plan, the creation of a national park in the area of Vålådalen-Sylarna-Helags in the county of Jämtland was recommended. This area covers in part the land used by Handölsdalen, Mittådalen and Tåssåsen samebys for reindeer herding, and, in May 2016, the samebys declared that they would oppose the national park project. Negotiations between the samebys on the one hand, and the authorities in charge of running the project – the Swedish Environmental Protection Agency and the County Administrative Board of Jämtland – took place, until, in May 2017, the project actors officially met all for the first time. The samebys most notably demanded that reindeer herding and the Saami culture are recognised in the national park, and that the samebys have a clear influence in the project and later in the park management. Despite being overrepresented in national parks, Saami reindeer herders remain in fact underrepresented in the management of these parks, and still struggle locally to be included in conservation projects. In parallel to the progressive recognition of their rights as an indigenous people and within a national trend fostering local participation, they have been however increasingly included in the discussions on conservation projects at the local scale. This thesis aims at contributing to challenge the way conservation is still conceptualised and practiced in Sweden. It raises the question of what the opportunities are for the affected samebys to anchor their claims in the negotiations over the establishment of a planned national park in the area of Vålådalen-Sylarna-Helags. The question is studied through the lens of the discursive institutional conflict management analysis, which allows to have a deep understanding of the negotiation process, by looking at its procedural as well as contextual aspects, and at the interdependence between the samebys and the authorities. Overall, the procedural aspects of the negotiation process are unfavourable to the samebys, the contextual aspects provide only mixed opportunities for the samebys, and the interdependence of the parties, while positive, is weak in degree which may hamper the anchoring of samebys' claims. This thesis demonstrates the importance of institutional change and building of trust for the effective recognition and participation of the samebys in the process.

  • Aaboud, M.
    et al.
    Université Mohamed Premier, Faculté des Sciences; LPTPM, Oujda.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Maddocks, H.J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander K
    DESY, Hamburg and Zeuthen.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva.
    Studies of Z gamma production in association with a high-mass dijet system in pp collisions at root s=8 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 107Article in journal (Refereed)
    Abstract [en]

    The production of a Z boson and a photon in association with a high-mass dijet system is studied using 20.2 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 8TeV recorded with the ATLAS detector in 2012 at the Large Hadron Collider. Final states with a photon and a Z boson decaying into a pair of either electrons, muons, or neutrinos are analysed. Electroweak and total pp -> Z gamma jj cross-sections are extracted in two fiducial regions with different sensitivities to electroweak production processes. Quartic couplings of vector bosons are studied in regions of phase space with an enhanced contribution from pure electroweak production, sensitive to vector-boson scattering processes VV -> Z gamma. No deviations from Standard Model predictions are observed and constraints are placed on anomalous couplings parameterized by higher-dimensional operators using effective field theory.

  • Boberg, Pia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Koo Clavensjö, Tracey
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    M-hälsa (mHealth) som en integrerad del i hälso- och sjukvården inom kardiovaskulärsjukdom: En litteraturstudie2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background

    Cardiovascular disease is the leading cause of death globally. Today's initiatives regarding prevention and treatment of cardiovascular disease still have unmet needs and improvement potential. One important and relevant part for the health care is to adapt to today's living habits. Digitalization has become a natural part in society and integration in health care is ongoing through so called eHealth. mHealth, which provides health care and prevention remotely, is a part of eHealth. The development of mHealth in health care has intensified and with increasing demands, that it is evidence-based.

    Aim

    Through a literature study, investigate the evidence of mHealth and how mHealth can influence risk factors in the treatment of cardiovascular disease.

    Method

    A descriptive literature study with a systematic approach that included 15 articles in total and all were randomized controlled trials.

    Results

    This literature study showed that motivational focused text message, by using mobile phone or smartphone, was the type of mHealth that was primarily used and was the most effective in influencing risk factors for cardiovascular disease. BMI, unhealthy diet and lack of exercise were the risk factors that were influenced primarily. Information about required resources for implementation of mHealth was not found.

    Conclusion

    mHealth as an integrated part of health care for cardiovascular disease provides advantages as it has shown effects on influential risk factors for cardiovascular disease. This, through text messages of motivational nature to a mobile phone or smartphone. mHealth should be considered in everything that is linked to health care and particularly within cardiovascular disease.

  • Lawler, Katherine
    et al.
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Ins Math & Mol Biomed, Hodgkin Bldg,Guys Campus, London SE1 1UL, England..
    Papouli, Efterpi
    Guys & St Thomas NHS Fdn Trust, NIHR Comprehens Biomed Res Ctr, London WC2R 2LS, England.;Kings Coll London, London WC2R 2LS, England..
    Naceur-Lombardelli, Cristina
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Mera, Anca
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England.;Kings Coll London, Guys Hosp, Canc Epidemiol Unit, London SE1 9RT, England..
    Ougham, Kayleigh
    Kings Coll London, Guys Hosp, Canc Bioinformat, Innovat Ctr,Canc Ctr, London SE1 9RT, England..
    Tutt, Andrew
    Kimbung, Siker
    Kings Coll London, Breast Canc Now Res Unit, Kings Hlth Partners AHSC, Canc Ctr,Guys Hosp,Innovat Ctr,Fac Life Sci & Med, London SE1 9RT, England.;Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden.;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden..
    Hedenfalk, Ingrid
    Kings Coll London, Breast Canc Now Res Unit, Kings Hlth Partners AHSC, Canc Ctr,Guys Hosp,Innovat Ctr,Fac Life Sci & Med, London SE1 9RT, England.;Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden.;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden..
    Zhan, Jun
    Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China.;Peking Univ, Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Hlth Sci Ctr, Beijing, Peoples R China..
    Zhang, Hongquan
    Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China.;Peking Univ, Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Hlth Sci Ctr, Beijing, Peoples R China..
    Buus, Richard
    Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London, England..
    Dowsett, Mitch
    Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London, England..
    Ng, Tony
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Richard Dimbleby Dept Canc Res, Randall Div Cell & Mol Biophys, Guys Campus, London SE1 1UL, England.;UCL, UCL Canc Inst, Paul OGorman Bldg, London WC1E 6DD, England..
    Pinder, Sarah E.
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Parker, Peter
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;London Res Inst, Lincolns Inn Fields, London WC2A 3LY, England..
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Kings Coll London, Guys Hosp, Canc Epidemiol Unit, London SE1 9RT, England.
    Gillett, Cheryl E.
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Grigoriadis, Anita
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England.;Kings Coll London, Guys Hosp, Canc Bioinformat, Innovat Ctr,Canc Ctr, London SE1 9RT, England..
    Purushotham, Arnie
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study2017In: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 19, 113Article in journal (Refereed)
    Abstract [en]

    Background: Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of metastastic spread in a clinical population are limited.

    Methods: A case-control design including 1357 primary breast cancers was used to study three distinct clinical patterns of metastasis, which occur within the first six months of metastatic disease: bone and visceral metasynchronous spread, bone-only, and visceral-only metastasis. Whole-genome expression profiles were obtained using whole genome (WG)-DASL assays from formalin-fixed paraffin-embedded (FFPE) samples. A systematic protocol was developed for handling FFPE samples together with stringent data quality controls to identify robust expression profiling data. A panel of published and novel gene sets were tested for association with these specific patterns of metastatic spread and odds ratios (ORs) were calculated.

    Results: Metasynchronous metastasis to bone and viscera was found in all intrinsic breast cancer subtypes, while immunohistochemically (IHC)-defined receptor status and specific IntClust subgroups were risk factors for visceral-only or bone-only first metastases. Among gene modules, those related to proliferation increased the risk of metasynchronous metastasis (OR (95% CI) = 2.3 (1.1-4.8)) and visceral-only first metastasis (OR (95% CI) = 2.5 (1.2-5.1)) but not bone-only metastasis (OR (95% CI) = 0.97 (0.56-1.7)). A 21-gene module (BV) was identified in estrogen-receptor-positive breast cancers with metasynchronous metastasis to bone and viscera (area under the curve = 0.77), and its expression increased the risk of bone and visceral metasynchronous spread in this population. BV was further orthogonally validated with NanoString nCounter in primary breast cancers, and was reproducible in their matched lymph nodes metastases and an external cohort.

    Conclusion: This case-control study of WG-DASL global expression profiles from FFPE tumour samples, after careful quality control and RNA selection, revealed that gene modules in the primary tumour have differing risks for clinical patterns of metasynchronous first metastases. Moreover, a novel gene module was identified as a putative risk factor for metasynchronous bone and visceral first metastatic spread, with potential implications for disease monitoring and treatment planning.

  • Fridriksson, Jon Orn
    et al.
    Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
    Folkvaljon, Yasin
    Uppsala Univ Hosp, Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden..
    Lundstrom, Karl-Johan
    Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
    Robinson, David
    Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.;Ryhov Hosp, Dept Urol, Jonkoping, Sweden..
    Carlsson, Stefan
    Karolinska Inst, Dept Mol Med & Surg, Sect Urol, Stockholm, Sweden..
    Stattin, Par
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.
    Long-term adverse effects after retropubic and robot-assisted radical prostatectomy: Nationwide, population-based study2017In: Journal of Surgical Oncology, ISSN 0022-4790, E-ISSN 1096-9098, Vol. 116, no 4, 500-506 p.Article in journal (Refereed)
    Abstract [en]

    Background and ObjectivesSurgery for prostate cancer is associated with adverse effects. We studied long-term risk of adverse effects after retropubic (RRP) and robot-assisted radical prostatectomy (RARP). MethodsIn the National Prostate Cancer Register of Sweden, men who had undergone radical prostatectomy (RP) between 2004 and 2014 were identified. Diagnoses and procedures indicating adverse postoperative effects were retrieved from the National Patient Register. Relative risk (RR) of adverse effects after RARP versus RRP was calculated in multivariable analyses adjusting for year of surgery, hospital surgical volume, T stage, Gleason grade, PSA level at diagnosis, patient age, comorbidity, and educational level. ResultsA total of 11212 men underwent RRP and 8500 RARP. Risk of anastomotic stricture was lower after RARP than RRP, RR for diagnoses 0.51 (95%CI=0.42-0.63) and RR for procedures 0.46 (95%CI=0.38-0.55). Risk of inguinal hernia was similar after RARP and RRP but risk of incisional hernia was higher after RARP, RR for diagnoses 1.48 (95%CI=1.01-2.16), and RR for procedures 1.52 (95%CI=1.02-2.26). ConclusionsThe postoperative risk profile for RARP and RRP was quite similar. However, risk of anastomotic stricture was lower and risk of incisional hernia higher after RARP.

  • Svedjemo, Gustaf
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Gårdar, byar och social struktur på Gotland under järnålder och medeltid2017In: Arkeologi på Gotland 2: Tillbakablickar och nya forskningsrön / [ed] Paul Wallin och Helene Martinsson-Wallin, Uppsala universitet/Campus Gotland: Institutionen för arkeologi och antik historia, Uppsala universitet & Gotlands museum , 2017, 183-190 p.Chapter in book (Other academic)
  • Larsson, Lennart
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages. Svenska Akademiens ordbok.
    Vilken plats hade kvinnan?: Om grammatiskt och sexuellt genus i SAOL:s sjunde upplaga 19002017In: Språk & Stil, ISSN 1101-1165, Vol. NF 27, 49-66 p.Article in journal (Refereed)
    Abstract [en]

    In the seventh edition of The Swedish Academy Glossary (SAOL) in 1900, biologically based gender was included in addition to grammatical gender. This required the SAOL editor to take a stance as to the sex of the non-neuter nouns referring to persons: Was it a question of men or women or both? Based on the SAOL gender designations, this article discusses those factors, both linguistic and non-linguistic, that were determinative for the editor’s classification. That a word’s traditional grammatical gender continued to play an important role is clear: a significant number of the personal nouns received the designation “m.” (masculine) or “f.” (feminine) regardless of the sex of the reference. And although many of the personal nouns that traditionally were classified as masculine in the 1900 edition were designated as “mf.” (masculine and feminine), a significant discrepancy can be traced between the SAOL gender designations and the reality outside the linguistic world – the place women received in SAOL is considerably narrower than that which was the actual case for women at the turn of the 19th century.

  • Holmqvist, Ulrika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Nordlund, Hanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Bedömning av språk och kommunikation vid 18-månadersbesöket: En intervjustudie med BVC-sjuksköterskor om föräldraformuläret ITC2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Children in Sweden between zero and six years are offered regular health and developmental check-ups at the Child Health Centre (CHC). One of these check-ups, when the child is 18 months old includes a speech-language check-up. Today, the check-up is not evidence-based. Therefore, the parent questionnaire Infant Toddler Checklist (ITC) was introduced in Uppsala county in the check-up at 18 months. The aim of the study was to explore how nurses at the CHC experienced the questionnaire and to get an understanding of how the method functioned in the CHC. The participants were recruited from four Child Health Centres with different catchment areas. The method was qualitative with semi-structured interviews in three focus groups. The interviews were transcribed and the analysis was conducted using systematic text condensation. The analysis resulted in four over all themes addressing the nurses' experiences with the new method. The results indicated that the questionnaire seemed to empower both parents and nurses. The nurses considered that the questionnaire worked as a basis for referral. The questionnaire was also perceived as making parents more aware and involved. The results also indicated that the questionnaire was seen as a useful tool but need to be modified to reach more families.

    Barn i Sverige mellan noll och sex år erbjuds återkommande hälsobedömningar på barnavårdscentralen (BVC). En av dessa bedömningar sker vid 18 månader då det bland annat görs en språklig bedömning. Som det ser ut idag finns ingen evidens för att den språkliga bedömningen i dess nuvarande utformning främjar sitt syfte. Till följd av detta har man i Uppsala län prövat föräldraformuläret Infant Toddler Checklist (ITC) vid 18- månaderbesöket. Syftet med studien var att undersöka hur barnhälsovårdssjuksköterskorna upplevde formuläret ITC samt få en förståelse för hur metoden fungerade i barnhälsovårdens verksamhet. Fjorton deltagare rekryterades från fyra barnavårdscentraler i Uppsala län med varierande upptagningsområden. Studien använde kvalitativ metod med semistrukturerade fokusgruppsintervjuer. Intervjuerna transkriberades och analyserades med systematisk textkondensering. Analysen resulterade i fyra övergripande teman som berörde BVC-sjuksköterskornas upplevelser av den nya metoden. Resultatet visade att formuläret upplevdes stärka både föräldrar och sjuksköterskor. BVC-sjuksköterskorna ansåg att formuläret gav dem underlag för remittering och att föräldrarna upplevdes bli mer delaktiga och medvetna. Vidare indikerade resultatet att formuläret ansågs vara ett användbart verktyg men att det behövde modifieras för att kunna nå ut till fler familjer.

  • Dunne, Lawrence J.
    et al.
    London South Bank University, UK.
    Brändas, Erkki J.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry. Uppsala University.
    Cox, Hazel
    University of Sussex, UK.
    High Temperature Superconductivity in Strongly Correlated Electronic Systems2017In: Advances in Quantum Chemistry, ISSN 0065-3276, E-ISSN 2162-8815, Vol. 74, 183-208 p.Article in journal (Refereed)
    Abstract [en]

    In this paper, we give a selective review of our work on the role of electron correlation in the theory of high-temperature superconductivity. The question of how electronic repulsions might give rise to off-diagonal long-range order (ODLRO) in high-temperature superconductors is currently one of the key questions in the theory of condensed matter. This paper argues that the key to understanding the occurrence of high-temperature superconductivity (HTSC) in cuprates is to be found in the Bohm-Pines Hamiltonian modified to include a polarizable dielectric background. The approach uses reduced electronic density matrices and discusses how these can be used to understand whether ODLRO giving rise to superconductivity might arise from a Bohm-Pines type potential which is comprised of a weak long-range attractive tail and a much stronger short-range repulsive Coulomb interaction. This allows time-reversed electron pairs to undergo a superconducting condensation on alternant Cuprate lattices. Thus, a detailed summary is given of the arguments that such interacting electrons can cooperate to produce a superconducting state in which time-reversed pairs of electrons effectively avoid the repulsive hard-core of the inter-electronic Coulomb interaction but reside on average in the attractive well of the effective potential. In a superconductor, the plasma wave function becomes the longitudinal component of a massive photon by the Anderson-Higgs mechanism. The alternant cuprate lattice structure is the key to achieving HTSC in cuprates with dx2-y2 symmetry condensate symmetry.

  • Öberg, Viktor A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Zhang, Xiaoliang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Johansson, Malin B.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Johansson, Erik M.J.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Solution-Processed Environmentally Friendly Ag2S Colloidal Quantum Dot Solar Cells with Broad Spectral Absorption2017In: Applied Sciences, E-ISSN 2076-3417, Vol. 7, no 10, 1020Article in journal (Refereed)
    Abstract [en]

    A facile heat-up synthesis route is used to synthesize environmentally friendly Ag2S colloidal quantum dots (CQDs) that are applied as light absorbing material in solid state p-i-n junction solar cell devices. The as-synthesized Ag2S CQDs have an average size of around 3.5 nm and exhibit broad light absorption covering ultraviolet, visible, and near infrared wavelength regions. The solar cell devices are constructed with a device architecture of FTO/TiO2/Ag2S CQDs/hole transport material (HTM) /Au using a solution-processed approach. Different HTMs, N2,N2,N2′,N2′,N7,N7,N7′,N7′-octakis(4-methoxyphenyl)-9,9′-spirobi(9H-fluorene)-2,2′,7,7′ tetramine (spiro-OMeTAD), poly(3-hexylthiophene-2,5-diyl) (P3HT), and poly((2,3-bis(3-octyloxyphenyl)-5,8-quinoxalinediyl)-2,5-thiophenediyl) TQ1 are studied for maximizing the device photovoltaic performance. The solar cell device with P3HT as a hole transport material gives the highest performance and the solar cell exhibit broad spectral absorption. These results indicate that Ag2S CQD have high potential for utilization as environmentally friendly light absorbing materials for solar cell application and that the hole transport material is critical to maximize the solar cell photovoltaic performance.

  • Westermark, Pontus
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Analysis and Probability Theory.
    Wavelets, Scattering transforms and Convolutional neural networks: Tools for image processing2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Jansson, Peter
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Lantz, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Räkneuppgifter till Säkerhetsanalyser inom energisektorn2018Book (Other academic)
  • Söderman, Jenny
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Wiborg, Jenny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Logopedi.
    Jämförelse och utvärdering av bedömningsmaterial inom kommunikationspartnerträning vid afasi: Bedömning av inter- och intrabedömarreliabilitet2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Approximately 10 000 individuals in Sweden are diagnosed with aphasia every year, which can result in severe communication difficulties. Conversation partner training (CPT) is a treatment that aims to help the person with aphasia and their communication partner to have a functional communication. CPT has shown to be an efficient treatment and is recommended in the Swedish national stroke rehabilitation guidelines. The present study examines the inter- and intra-rater reliability of five different CPT assessment materials with intraclass correlation (ICC) for CPT in aphasia. The assessment materials evaluated and compared in this study were Measure of skill in supported conversation (MSC), Measure of participation in conversation (MPC) and the Swedish adaptations Measure of interaction in conversation (MIC/MIK), Stöd i konversation (SiK) and Deltagande i konversation (DiK). The study also examines if assessment training increases the inter-rater reliability, and also if there is any correlation between the type and severity of aphasia and inter-rater reliability. Fourteen dyads participated in the study. The analyses are based on 10 minutes long video clips where the dyads are having a conversation on an optional topic. The results indicated that the assessment materials with the highest inter-rater reliability were SiK and DiK (ICC > 0.65, p < 0,001) and the assessment material with highest intra-rater reliability was MSC for assessor number one (0.91, p < 0.001) and MIC for assessor number two (0.83, p < 0.001). The results also imply that there are no significant differences in inter-rater reliability between assessments before and after assessment training. Correlation between type of aphasia and inter-rater reliability was found in SiK (r = 0.65 p = 0.013). No correlation was found for the variable severity of aphasia and inter-rater reliability.

    Varje år drabbas ca 10 000 personer av afasi i Sverige, vilket kan medföra stora kommunikativa svårigheter. Kommunikationspartnerträning (KPT) är en behandling som hjälper den drabbade och dennes samtalspartner att kommunicera på ett funktionellt sätt. Studier visar att KPT är en effektiv behandlingsmetod och i Socialstyrelsens reviderade nationella strokeriktlinjer rekommenderas denna metod. Föreliggande studie undersöker inter- och intrabedömarreliabiliteten med intraclass correlation (ICC) för fem olika bedömningsmaterial för KPT vid afasi. Bedömningsmaterialen som jämförts och utvärderats är Measure of skill in supported conversation (MSC), Measure of participation in conversation (MPC), och de svenska anpassningarna Mått på interaktion i kommunikation (MiK) och Stöd i konversation (SiK) respektive Deltagande i konversation (DiK). Studien utforskar också om samstämmighetsträning förbättrar interbedömarreliabiliteten samt om det finns något samband mellan typ och grad av afasi och interbedömarreliabilitet. Fjorton dyader deltog i studien. Analysen genomfördes utifrån filmklipp på cirka 10 minuter där deltagarna samtalade om valfritt ämne. Resultaten visade att SiK och DiK hade högst interbedömarreliabilitet (ICC > 0,65, p < 0,001). Bedömningsmaterialet med högst intrabedömarreliabilitet var MSC för bedömare 1 (0,91, p < 0,001), och MIK för bedömare 2 (0,83 p < 0,001). Resultaten i föreliggande studie visade inga signifikanta skillnader i interbedömarreliabilitet mellan testning före respektive efter träning av samstämmighet. Korrelation mellan typ av afasi och interbedömarreliabilitet kunde påvisas för SiK (r = 0,65 p = 0,013). Korrelation mellan grad av afasi och interbedömarreliabilitet kunde ej påvisas.

  • Ujvari, Gabor
    et al.
    Hungarian Academy of Sciences, Budapest, Hungary; Technical University of Denmark, Roskilde, Denmark.
    Stevens, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Molnar, Mihaly
    Hungarian Academy of Sciences, Debrecen, Hungary.
    Demeny, Attila
    Hungarian Academy of Sciences, Budapest, Hungary.
    Lambert, Fabrice
    Geography Institute, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Varga, Gyorgy
    Hungarian Academy of Sciences, Budapest, Hungary.
    Jull, A. J. Timothy
    Department of Geosciences, University of Arizona, Tucson, USA.
    Pall-Gergely, Barna
    Hungarian Academy of Sciences, Budapest, Hungary.
    Buylaert, Jan-Pieter
    Center for Nuclear Technologies, Technical University of Denmark, Roskilde, Denmark; University of Aarhus, Roskilde, Denmark .
    Kovacs, Janos
    Department of Geology and Meteorology, University of Pécs, Hungary; Szentágothai Research Centre, Pécs, Hungary.
    Coupled European and Greenland last glacial dust activity driven by North Atlantic climate2017In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 114, no 50, E10632-E10638 p.Article in journal (Refereed)
    Abstract [en]

    Centennial-scale mineral dust peaks in last glacial Greenland ice cores match the timing of lowest Greenland temperatures, yet little is known of equivalent changes in dust-emitting regions, limiting our understanding of dust−climate interaction. Here, we present the most detailed and precise age model for European loess dust deposits to date, based on 125 accelerator mass spectrometry 14C ages from Dunaszekcső, Hungary. The record shows that variations in glacial dust deposition variability on centennial–millennial timescales in east central Europe and Greenland were synchronous within uncertainty. We suggest that precipitation and atmospheric circulation changes were likely the major influences on European glacial dust activity and propose that European dust emissions were modulated by dominant phases of the North Atlantic Oscillation, which had a major influence on vegetation and local climate of European dust source regions.

  • Hosseinali Khani, Maziar
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanlands Hosp Vasteras, Dept Surg, SE-72189 Vasteras, Swedeno.
    Ji, Jianguang
    Lund Univ, Ctr Primary Hlth Care Res, Dept Clin Sci, Lund, Sweden..
    Leppert, Jerzy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanlands Hosp Vasteras, Dept Med, SE-72189 Vasteras, Sweden..
    Sundquist, Kristina
    Lund Univ, Ctr Primary Hlth Care Res, Dept Clin Sci, Lund, Sweden..
    Chabok, Abbas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanlands Hosp Vasteras, Dept Surg, SE-72189 Vasteras, Sweden.
    Socioeconomic characteristics and comorbidities of diverticular disease in Sweden 1997-20122017In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 32, no 11, 1591-1596 p.Article in journal (Refereed)
    Abstract [en]

    Purpose: This study aimed to evaluate the association of socioeconomic status and comorbidities with uncomplicated and complicated diverticular disease (DD) in Sweden.

    Methods: We identified all individuals aged >= 30 years in Sweden diagnosed with DD between 1997 and 2012 using the Swedish National Population and Housing Census and the Hospital Discharge Register. Data were analyzed by multivariable logistic regression, with individual-level characteristics as covariates.

    Results: A total of 79,481 patients (median age 66 [range 3086] years) were hospitalized for DD, 15,878 (20%) of whom for complicated DD. Admissions for both uncomplicated and complicated DD were more common in women (p < 0.001). A low education level was identified as a risk factor for uncomplicated (unadjusted hazard ratio [HR] 1.79, 95% confidence interval [CI] 1.75-1.82; adjusted HR 1.22, 95% CI 1.19-1.24) and complicated DD(unadjusted HR 1.84, 95% CI 1.77-1.92; adjusted HR 1.26, 95% CI 1.21-1.32). Patients with the lowest income had a lower risk of hospitalization for uncomplicated (adjusted HR 0.94, 95% CI 0.91-0.96) and complicated DD (adjusted HR 0.87, 95% CI 0.83-0.92) than those with the highest income. The correlation coefficient between income and education was 0.25. Diabetes and cardiovascular disease were identified as protective factors against uncomplicated DD (adjusted HR 0.68, 95% CI 0.66-0.69 and HR 0.79, 95% CI 0.74-0.84, respectively).

    Conclusions: Patients with the lowest education level had an increased risk of hospitalization for DD. Further studies are needed to explore the association of diabetes and cardiovascular disease with uncomplicated DD.

  • Flowers, Sarah A.
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, Gothenburg, Sweden..
    Zieba, Agata
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Örnros, Jessica
    Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, Gothenburg, Sweden..
    Jin, Chunsheng
    Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, Gothenburg, Sweden..
    Rolfson, Ola
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Orthopaed, Gothenburg, Sweden..
    Björkman, Lena I.
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden..
    Eisler, Thomas
    Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden..
    Kalamajski, Sebastian
    Lund Univ, Dept Mol Skeletal Biol, Lund, Sweden..
    Kamali-Moghaddam, Masood
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Karlsson, Niclas G.
    Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Med Biochem & Cell Biol, Gothenburg, Sweden..
    Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 13149Article in journal (Refereed)
    Abstract [en]

    Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint. Immunohistochemical analysis of human cartilage biopsies showed lubricin and COMP co-localise to the cartilage surface. COMP knockout mice, however, presented with a lubricin layer on the articular cartilage leading to the further investigation of additional lubricin binding mechanisms. Proximity ligation assays (PLA) on human cartilage biopsies was used to localise additional lubricin binding partners and demonstrated that lubricin bound COMP, but also fibronectin and collagen II on the cartilage surface. Fibronectin and collagen II binding to lubricin was confirmed and characterised by solid phase binding assays with recombinant lubricin fragments. Overall, COMP, fibronectin and collagen II bind lubricin, exposed on the articular cartilage surface suggesting they may be involved in maintaining essential boundary lubrication.

  • Volodina, Elena
    et al.
    Megyesi, Beáta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Wirén, Mats
    Granstedt, Lena
    Prentice, Julia
    Reichenberg, Monica
    Sundberg, Gunlög
    A Friend in Need?: Research agenda for electronic Second Language infrastructure2016In: Proceedings of SLTC 2016, 2016Conference paper (Refereed)
    Abstract [en]

    In this article, we describe the research and societal needs as well as ongoing efforts to shape Swedish as a Second Language (L2) infrastructure. Our aim is to develop an electronic research infrastructure that would stimulate empiric research into learners' language development by preparing data and developing language technology methods and algorithms that can successfully deal with deviations in the learner language.

  • Borin, Lars
    et al.
    Språkbanken, Department of Swedish, University of Gothenburg.
    Tahmasebi, Nina
    Språkbanken, Department of Swedish, University of Gothenburg.
    Volodina, Elena
    Språkbanken, Department of Swedish, University of Gothenburg.
    Ekman, Stefan
    Swedish National Data Service, University of Gothenburg.
    Jordan, Caspar
    Swedish National Data Service, University of Gothenburg.
    Viklund, Jon
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature.
    Megyesi, Beáta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Näsman, Jesper
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Palmér, Anne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Wirén, Mats
    Department of Linguistics, Stockholm University.
    Björkenstam, Kristina
    Department of Linguistics, Stockholm University.
    Grigonytė, Gintaré
    Department of Linguistics, Stockholm University.
    Gustafson Capková, Sofia
    Department of Linguistics, Stockholm University.
    Kosiński, Tomasz
    Department of Applied IT, Chalmers University of Technology.
    Swe-Clarin: Language Resources and Technology for Digital Humanities2016In: Extended Papers of the International Symposium on Digital Humanities, 2016, 29-51 p.Conference paper (Refereed)
    Abstract [en]

    CLARIN is a European Research Infrastructure Consortium (ERIC), which aims at (a) making extensive language-based materials available as primary research data to the humanities and social sciences (HSS); and (b) offering state-of-the-art language technology (LT) as an eresearch tool for this purpose, positioning CLARIN centrally in what is often referred to as the digital humanities (DH). The Swedish CLARIN node Swe-Clarin was established in 2015 with funding from the Swedish Research Council.

    In this paper, we describe the composition and activities of Swe-Clarin, aiming at meeting the requirements of all HSS and other researchers whose research involves using text and speech as primary research data, and spreading the awareness of what Swe-Clarin can offer these research communities. We focus on one of the central means for doing this: pilot projects conducted in collaboration between HSS researchers and Swe-Clarin, together formulating a research question, the addressing of which requires working with large language-based materials. Four such pilot projects are described in more detail, illustrating research on rhetorical history, second-language acquisition, literature, and political science. A common thread to these projects is an aspiration to meet the challenge of conducting research on the basis of very large amounts of textual data in a consistent way without losing sight of the individual cases making up the mass of data, i.e., to be able to move between Moretti’s “distant” and “close reading” modes.

    While the pilot projects clearly make substantial contributions to DH, they also reveal some needs for more development, and in particular a need for document-level access to the text materials. As a consequence of this, work has now been initiated in Swe-Clarin to meet this need, so that Swe-Clarin together with HSS scholars investigating intricate research questions can take on the methodological challenges of big-data language-based digital humanities.

  • Näsman, Jesper
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Megyesi, Beáta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Palmér, Anne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    SWEGRAM: A Web-Based Tool for Automatic Annotation and Analysis of Swedish Texts2017In: Proceedings of the 21st Nordic Conference on Computational Linguistics, Nodalida 2017., Göteborg, 2017, 132-141 p.Conference paper (Refereed)
    Abstract [en]

    We present SWEGRAM, a web-based tool for the automatic linguistic annotation and quantitative analysis of Swedish text, enabling researchers in the humanities and social sciences to annotate their own text and produce statistics on linguistic and other text-related features on the basis of this annotation. The tool allows users to upload one or several documents, which are automatically fed into a pipeline of tools for tokenization and sentence segmentation, spell checking, part-of-speech tagging and morpho-syntactic analysis as well as dependency parsing for syntactic annotation of sentences. The analyzer provides statistics on the number of tokens, words and sentences, the number of parts of speech (PoS), readability measures, the average length of various units, and frequency lists of tokens, lemmas, PoS, and spelling errors. SWEGRAM allows users to create their own corpus or compare texts on various linguistic levels.

  • Stymne, Sara
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Pettersson, Eva
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Megyesi, Beáta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Palmér, Anne
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    Annotating Errors in Student Texts: First Experiences and Experiments2017In: Proceedings of Joint 6th NLP4CALL and 2nd NLP4LA Nodalida workshop, Göteborg, 2017, 47-60 p.Conference paper (Refereed)
    Abstract [en]

    We describe the creation of an annotation layer for word-based writing errors for a corpus of student writings. The texts are written in Swedish by students between 9 and 19 years old. Our main purpose is to identify errors regarding spelling, split compounds and merged words. In addition, we also identify simple word-based grammatical errors, including morphological errors and extra words. In this paper we describe the corpus and the annotation process, including detailed descriptions of the error types and guidelines. We find that we can perform this annotation with a substantial inter-annotator agreement, but that there are still some remaining issues with the annotation. We also report results on two pilot experiments regarding spelling correction and the consistency of downstream NLP tools, to exemplify the usefulness of the annotated corpus.

  • Fornes, Alicia
    et al.
    Computer Vision Center, Universitat Autònoma de Barcelona, Spain.
    Megyesi, Beáta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Mas, Joan
    Computer Vision Center, Universitat Autònoma de Barcelona, Spain.
    Transcription of Encoded Manuscripts with Image Processing Techniques2017In: Proceedings of Digital Humanities 2017., Canada, 2017Conference paper (Refereed)
  • Björklund, Erik
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Brandell, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Hahlin, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Edström, Kristina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Younesi, Reza
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    The influence of counter electrode on the capacity fading in LiNi0.33Mn0.33Co0.33O2-based Li-ion battery cells2017Conference paper (Other academic)
  • Etman, Ahmed S.
    et al.
    Berzelii Center EXSELENT on Porous Materials, Department of Material and Environmental Chemistry (MMK), Stockholm University, Sweden.
    Inge, Andrew Kentaro
    Berzelii Center EXSELENT on Porous Materials, Department of Material and Environmental Chemistry (MMK), Stockholm University, Sweden.
    Jiaru, Xu
    College of Chemistry and Molecular Engineering, Peking University, China.
    Younesi, Reza
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Edström, Kristina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Sun, Junliang
    Berzelii Center EXSELENT on Porous Materials, Department of Material and Environmental Chemistry (MMK), Stockholm University, Sweden; College of Chemistry and Molecular Engineering, Peking University, China.
    Simple and Green Method for Fabricating V2O5·nH2O Nanosheets for Lithium Battery Application2017Conference paper (Other academic)
    Abstract [en]

    During the last few years, the synthesis of inorganic two dimensional (2D) materials tremendously increased, due to their promising surface area1,2. However, the synthesis of these 2D materials can significantly influence our environment, by the use of harmful chemicals and severe reaction conditions3,4.

    Herein, we report on a simple and green strategy for fabricating hydrated vanadium pentoxide (V2O5.nH2O) nanosheets from commercially available vanadium oxides precursors via water based exfoliation technique. Operando and ex situ X-ray diffraction (XRD) studies were conducted to track the structural changes during the exfoliation process. The vanadium oxidation states and the water content of the material were determined by X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA), respectively. Electron microscopy and atomic force microscopy (AFM) showed that the V2O5.nH2O is composed of a few nanometer thick nanosheets. A composite material of the V2O5∙nH2O nanosheets and multi-walled carbon nanotube (MW-CNT) were fabricated and then tested as a free standing electrodes (FSE) and conventionally casted electrodes (CCE) for lithium battery. Both electrodes showed promising capacities and rate capabilities for lithium-ion intercalation.

    References:

    (1) Nicolosi, V.; Chhowalla, M.; Kanatzidis, M. G.; Strano, M. S.; Coleman, J. N. Liquid Exfoliation of Layered Materials. Science (80-. ). 2013, 340 (6139), 1226419.

    (2) Etman, A. S.; Asfaw, H. D.; Yuan, N.; Li, J.; Zhou, Z.; Peng, F.; Persson, I.; Zou, X.; Gustafsson, T.; Edström, K.; Sun, J. A One-Step Water Based Strategy for Synthesizing Hydrated Vanadium Pentoxide Nanosheets from VO2 (B) as Free-Standing Electrodes for Lithium Battery Applications. J. Mater. Chem. A 2016, 4 (46), 17988–18001.

    (3) Wei, Q.; Liu, J.; Feng, W.; Sheng, J.; Tian, X.; He, L.; An, Q.; Mai, L. Hydrated Vanadium Pentoxide with Superior Sodium Storage Capacity. J. Mater. Chem. A 2015, 3, 8070–8075.

    (4) Zhou, K.-G.; Mao, N.-N.; Wang, H.-X.; Peng, Y.; Zhang, H.-L. A Mixed-Solvent Strategy for Efficient Exfoliation of Inorganic Graphene Analogues. Angew. Chem. Int. Ed. Engl. 2011, 50 (46), 10839–10842.

  • Edström, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Brant, William
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Probing the origins of electrochemical properties in electrodes for lithium ion batteries through in operando diffraction2017Conference paper (Other academic)
    Abstract [en]

    In operando diffraction methods are widely employed to qualitatively follow the reaction progression in operating battery electrodes. However, performing thorough structural analysis with the aim of understanding the origins of battery performance during electrochemical cycling is significantly less common. There exists a unique opportunity to further exploit in operando diffraction to extract detailed information on the dynamic changes taking place to the electrode materials during battery operation. With careful experimental design, in operando methods provide a unique perspective on understanding the electrochemical processes in electrode materials. Tracking the rate of phase conversion throughout a battery electrode, for example, provides insight into the competing sources of resistance in an electrode under different cycling conditions. Further, subtleties in the electrochemical reaction of battery electrodes, such as differences in structural changes between lithium insertion and extraction from a host material, can be identified.

    By changing the focus from simple phase identification towards more detailed structural analyses, in operando neutron diffraction becomes increasingly attractive. While there has been rapidly growing interest in performing in operando neutron diffraction experiments for lithium ion batteries, it remains a relatively inaccessible technique due to the difficulty of preparing custom cells with adequate electrochemical performance. Multiple custom cells inspired by commercial cell designs have been investigated within our group with the aim of fine tuning the electrochemical performance while maintaining high quality diffraction data for Rietveld analysis.

    Using LiFePO4, LiNi0.5Mn1.5O4 and LiFeSO4F as case study materials, this contribution will focus on investigations of electrochemical properties of battery electrodes using the dynamic structural response taking place during cell operation.

  • Public defence: 2018-01-29 09:15 Room B42, Uppsala
    Maturi, Varun
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Gene regulation by different proteins of TGFβ superfamily2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling.

    The importance of the poly ADP-ribose polymerase (PARP) family in controlling gene expression in response to TGFβ and bone morphogenetic protein (BMP) is analyzed first. PARP2, along with PARP1, ADP-ribosylates Smad2 and Smad3, the signaling mediators of TGFβ. On the other hand, poly ADP-ribose glycohydrolase (PARG) removes the ADP-ribose from Smad2/3 and antagonizes PARP1 and PARP2. ADP-ribosylation of Smads in turn affects their DNA binding capacity. We then illustrate how PARP1 and PARG can regulate gene expression in response to BMP that signals via Smad1, 5. Over-expression of PARP1 suppressed the transcriptional activity of Smad1/5. Knockdown of PARP1 or over-expression of PARG enhanced the transcriptional activity of BMP-Smads on target genes. Hence our data suggest that ADP-ribosylation of Smad proteins controls both TGFβ and BMP signaling. 

    I then focus on elucidating novel genes that are regulated by ZEB1 and Snail1, two key transcriptional factors in TGFβ signaling, known for their ability to induce EMT and cancer metastasis. Chromatin immunoprecipitation-sequencing (ChIP-seq) and targeted whole genome transcriptomics in triple negative breast cancer cells were used, to find binding regions and the functional impact of ZEB1 and Snail1 throughout the genome. ZEB1 binds to the regulatory sequences of a wide range of genes, not only related to cell invasion, pointing to new functions of ZEB1. On the other hand, Snail1 regulated only a few genes, especially related to signal transduction and cellular movement. Further functional analysis revealed that ZEB1 could regulate the anchorage-independent growth of the triple negative breast cancer cells, whereas Snail1 could regulate the expression of BMP6 in these cells. We have therefore elucidated novel functional roles of the two transcription factors, Snail1 and ZEB1 in triple negative breast cancer cells.

    List of papers
    1. Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
    Open this publication in new window or tab >>Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
    Show others...
    2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 8, e103651- p.Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND:

    Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation. We previously reported that ADP-ribosylation of Smads by poly(ADP-ribose) polymerase 1 (PARP-1) negatively influences Smad-mediated transcription. PARP-1 is known to functionally interact with PARP-2 in the nucleus and the enzyme poly(ADP-ribose) glycohydrolase (PARG) can remove poly(ADP-ribose) chains from target proteins. Here we aimed at analyzing possible cooperation between PARP-1, PARP-2 and PARG in regulation of TGFβ signaling.

    METHODS:

    A robust cell model of TGFβ signaling, i.e. human HaCaT keratinocytes, was used. Endogenous Smad3 ADP-ribosylation and protein complexes between Smads and PARPs were studied using proximity ligation assays and co-immunoprecipitation assays, which were complemented by in vitro ADP-ribosylation assays using recombinant proteins. Real-time RT-PCR analysis of mRNA levels and promoter-reporter assays provided quantitative analysis of gene expression in response to TGFβ stimulation and after genetic perturbations of PARP-1/-2 and PARG based on RNA interference.

    RESULTS:

    TGFβ signaling rapidly induces nuclear ADP-ribosylation of Smad3 that coincides with a relative enhancement of nuclear complexes of Smads with PARP-1 and PARP-2. Inversely, PARG interacts with Smads and can de-ADP-ribosylate Smad3 in vitro. PARP-1 and PARP-2 also form complexes with each other, and Smads interact and activate auto-ADP-ribosylation of both PARP-1 and PARP-2. PARP-2, similar to PARP-1, negatively regulates specific TGFβ target genes (fibronectin, Smad7) and Smad transcriptional responses, and PARG positively regulates these genes. Accordingly, inhibition of TGFβ-mediated transcription caused by silencing endogenous PARG expression could be relieved after simultaneous depletion of PARP-1.

    CONCLUSION:

    Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFβ signaling.

    National Category
    Clinical Medicine
    Identifiers
    urn:nbn:se:uu:diva-231920 (URN)10.1371/journal.pone.0103651 (DOI)000341302700014 ()25133494 (PubMedID)
    Available from: 2014-09-11 Created: 2014-09-11 Last updated: 2017-12-05Bibliographically approved
    2. Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation
    Open this publication in new window or tab >>Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation
    Show others...
    2016 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 291, no 24, 12706-12723 p.Article in journal (Refereed) Published
    Abstract [en]

    We previously established a mechanism of negative regulation of transforming growth factor beta signaling mediated by the nuclear ADP-ribosylating enzyme poly-(ADP-ribose) polymerase 1 (PARP1) and the deribosylating enzyme poly-(ADP-ribose) glycohydrolase (PARG), which dynamically regulate ADP-ribosylation of Smad3 and Smad4, two central signaling proteins of the pathway. Here we demonstrate that the bone morphogenetic protein (BMP) pathway can also be regulated by the opposing actions of PARP1 and PARG. PARG positively contributes to BMP signaling and forms physical complexes with Smad5 and Smad4. The positive role PARG plays during BMP signaling can be neutralized by PARP1, as demonstrated by experiments where PARG and PARP1 are simultaneously silenced. In contrast to PARG, ectopic expression of PARP1 suppresses BMP signaling, whereas silencing of endogenous PARP1 enhances signaling and BMP-induced differentiation. The two major Smad proteins of the BMP pathway, Smad1 and Smad5, interact with PARP1 and can be ADP-ribosylated in vitro, whereas PARG causes deribosylation. The overall outcome of this mode of regulation of BMP signal transduction provides a fine-tuning mechanism based on the two major enzymes that control cellular ADP-ribosylation.

    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-299724 (URN)10.1074/jbc.M116.729699 (DOI)000378119900024 ()27129221 (PubMedID)
    Funder
    Swedish Research Council, K2010-67X-14936-07-3 K2013-66X-14936-10-5
    Available from: 2016-07-26 Created: 2016-07-26 Last updated: 2018-01-10Bibliographically approved
    3. Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
    Open this publication in new window or tab >>Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
    (English)Manuscript (preprint) (Other academic)
    Keyword
    ZEB1, EMT, ChIP-seq, CRISPR-Cas9
    National Category
    Cell Biology
    Research subject
    Biochemistry; Biology with specialization in Molecular Cell Biology
    Identifiers
    urn:nbn:se:uu:diva-334438 (URN)
    Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2017-11-30
    4. Genome-wide binding of transcription factor Snail1 in triple-negative breast cancer cells
    Open this publication in new window or tab >>Genome-wide binding of transcription factor Snail1 in triple-negative breast cancer cells
    (English)Manuscript (preprint) (Other academic)
    Keyword
    ChIP-Seq, Snail1, Ampliseq, EMtT, BMP6
    National Category
    Cell Biology
    Research subject
    Biochemistry; Biology with specialization in Molecular Cell Biology
    Identifiers
    urn:nbn:se:uu:diva-334433 (URN)
    Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2017-11-30
  • Bergstrand, Carl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Lydahl, Felicia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Depressionssymtom hos män vid blivande och nyblivet föräldraskap: En litteraturstudie2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Research on mental health related to parenting has for a long time been linked to the woman and the child's needs. Since the 1990s, research has increased in the field of postpartum depression (PPD). It is not until recently that the mental health of the fathers has been investigated more thoroughly. According to studies, between 6-10 % of future and first-time fathers suffer from depression symptoms. In addition to suffering in the father, negative consequences for both the partner and the child have been identified. Aim: The purpose was to illustrate depression symptoms in future and first-time fathers. Method: A literature study with a descriptive purpose with an inductive approach that examined relevant original articles that responded to the aim and issues of this study. The articles were quality tested initially with qualitative and quantitative quality assessment templates and then the result was analyzed. Results: Future and first-time fathers are at risk of depression before and after the child’s birth. The experience of this depression is associated with destructive thoughts and behavioral changes, which, apart from affecting the father's everyday life, have negative consequences for the family and for the child. Risk factors, including the partner’s depression, have been identified to further increase the risk of depression in fathers. Screening and strategies for identifying father’s depression are motivated, but proven to be insufficient. Routines, nursing and skills to include fathers need improvement in both maternity care center and child health care center. Dad groups are highly valued and have been shown to normalize first-time fathers existence. Conclusion: Fathers describe a wide range of negative emotions and behavioral changes. Fathers risk developing depression symptoms in the event of a possible depression in the mother. Support such as dad groups and being included by nurses and healthcare professionals are described as health factors that fathers appreciated.

  • Larsson, Julia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Nilsson, Angelica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Sexuell läggning och suicidala tankar hos ungdomar2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Mental illness is an increasing problem among adolescents. Suicidal ideation is an early stage of suicide and different risk factors can increase the risk of suicidal ideations. All over the world suicide is the third most common cause of death among adolescents aged 15 – 19 years. Suicide is a care-damage if the health service had the possibility to prevent a person to commit suicide with adequate interventions. Therefore, the health service is required to work preventive towards suicide. Suicide attempts is reported in higher rate among adolescents who are lesbian, gay or bisexual (LGB). Some patients perceived that health personnel sometimes saw homosexuality as something abnormal.

    Aim: The aim of the study was to describe the presence of suicidal ideations based on sexual orientation among adolescents.

    Method: The literature study includes ten articles. The quality of the articles was analyzed. Then the articles similarities and differences were described.   

    Results: Sexual orientation has an impact on suicidal ideations. Adolescents who were defined as LGB, sexual minority or had sexual contact with a person of the same gender reported suicidal ideation in a higher rate than heterosexual adolescents. Girls reported suicidal ideations in a higher rate than boys, regardless of sexual orientation.

    Conclusion: Studies shows that there is a correlation between sexual orientation and suicidal ideation. Suicidal ideation is a severe problem that can’t be disregard, and neither the correlation between sexual orientation and suicidal ideation. Therefore, research need to be done, both in Sweden and worldwide. 

  • Hansson, Per
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Complaints about Priests in the Church of Sweden from 2001–20132017In: Scandinavian Journal for Leadership & Theology, ISSN 0281-0573, E-ISSN 1891-473X, Vol. 4Article in journal (Refereed)
    Abstract [en]

    Media coverage of complaints about priests has generally focused on sexual misbehavior. This case study of complaints about priests in the Church of Sweden from 2001–2013 gives a much more varied picture. Documentation of all the complaints received during 2001, 2004, 2007, 2010 and 2013 was collected. In all, there are 199 complaints, which correspond to approximately 1.2% of priests every year. The rate of complaints rose and doubled, peaking in 2010. The complaints are categorized in three categories: general complaints, complaints that can lead to prohibition and other complaints. The most common complainant was the private individual (42%), although bishops and colleagues were also responsible for some of the complaints. During the years studied, private complaints increased. This finding is interpreted to reflect an increasing tendency in Swedish society to complain. Com- plaints about female priests are increasing and are now occurring at the same rate as for male priests. However, no female priests have been prohibited yet; only males have been. Sexual issues account for 15% of the complaints, which are outnumbered by other complaints. Decisions made by the Church chapters have changed during the studied years; earlier, the most common decision was to take no ac- tion, but later, the chapters generally decided on some type of action (for example, commissioning someone to talk to the priest or to give a statement).

  • Farisco, Michele
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics. Biogem, Genetic Research Centre, Ariano Irpino, Italy.
    Evers, Kathinka
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    The ethical relevance of the unconscious2017In: Philosophy Ethics and Humanities in Medicine, ISSN 1747-5341, E-ISSN 1747-5341, Vol. 12, no 11Article in journal (Refereed)
    Abstract [en]

    Background

    Ethical analyses of disorders of consciousness traditionally focus on residual awareness. Going one step further, this paper explores the potential ethical relevance of the unawareness retained by patients with disorders of consciousness, focusing specifically on the ethical implications of the description of the unconscious provided by recent scientific research.

    Methods

    A conceptual methodology is used, based on the review and analysis of relevant scientific literature on the unconscious and the logical argumentation in favour of the ethical conclusions.

    Results

    Two conditions (experiential wellbeing and having interests) that are generally considered critical components in the ethical discussion of patients with disorders of consciousness might arguably be both conscious and unconscious.

    Conclusions

    The unconscious, as well as consciousness, should be taken into account in the ethical discussions of patients with disorders of consciousness.

  • Robinson, Yohan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Olerud, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Willander, Johan
    Högskolan i Gävle.
    Do biological disease-modifying antirheumatic drugs reduce the spinal fracture risk related to ankylosing spondylitis?: A longitudinal multiregistry matched cohort study2017In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 12, e016548Article in journal (Refereed)
    Abstract [en]

    Objectives Ankylosing spondylitis (AS) is associated with an increased spinal fracture risk due to the loss of elasticity in spinal motion segments. With the introduction of biological disease-modifying antirheumatic drug (bDMARD) treatment for AS, the individual course of the disease has been ameliorated. This study aims to examine the association of bDMARD treatment and risk of spinal fracture.

    Design Longitudinal population-based multiregistry observational matched cohort study.

    Setting Swedish Patient Registry 1987–2014 and Swedish Prescribed Drugs Registry 2005–2014.

    Participants Included were patients ≥18 years of age receiving treatment at a healthcare facility for the primary diagnosis of AS. About 1352 patients received more than one prescription of bDMARD from 2005 to 2014. An untreated control group was created by propensity score matching for age, sex, comorbidity, antirheumatic prescriptions and years with AS (n=1352).

    Main outcome measures Spinal fracture-free survival.

    Results No bDMARD treatment-related effect on spinal fracture-free survival was observed in the matched cohorts. Male gender (HR=2.54, 95% CI 1.48 to 4.36) and Charlson Comorbidity Index score (HR=3.02, 95% CI 1.59 to 5.75) contributed significantly to spinal fracture risk.

    Conclusion bDMARD had no medium-term effect on the spinal fracture-free survival in patients with AS.

    Trial registration number NCT02840695

  • Boshuijzen-van Burken, Christine
    et al.
    Linnaeus University, Växjö, Sweden; Eindhoven University of Technology, Eindhoven, The Netherlands.
    Haftor, Darek
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media. Linnaeus University, Växjö, Sweden.
    An Assessment of the Uber App’s Normative Practice2017In: Philosophia Reformata, ISSN 0031-8035, Vol. 82, no 2, 192-215 p.Article in journal (Refereed)
    Abstract [en]

    This study analyzes a complex case in society, namely, how to distinguish ride-sharing applications, such as Uber, from ordinary taxi enterprises. We conduct a structural analysis of normative practices with distinctions at the following levels: (1) aspects; (2) radical types, genotypes, and phenotypes; (3) part-whole, enkaptic relationships, and interlinkages; and (4) the distinction between qualifying and foundational functions as it is captured in the theory of normative practices. We conclude that the genotype of taxi matchmaking enterprises, of which Uber is an example, represents a novel normativity that could positively serve society and also produce normative challenges, depending on its governance. Therefore, regulators should not dismiss the entire  genotype of taxi matchmaking enterprises, but should address the phenotypes that are illegal or that cannot thrive without the illegal behaviors of its users. This conclusion is clear from the structural and directional sides of the practice.