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  • Lejonklo, Caroline
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Friction and wear study of lean powder metallurgy steel in a lubricated sliding contact2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    A fairly new technology used to produce metallic components is powder metallurgy (PM). Among the advantages with this technique are decreased cost of production for complex-shaped parts, new alloys are made possible, reduced end processing, less material loss, and vibrational damping effects. The downside is the number of pores created which can alter the tribological properties of the material.

    The focus of this report is to investigate how lean PM steel behaves under tribological contacts.  Friction and wear will be investigated using a pin-on-disc setup to mimic the sliding part of a gear tooth mesh.

    Previous studies show that the amount of wear, and if the wear increases or decreases with increased density is dependent on the degree of porosity and the pore size. This means that the wear might be minimized by optimizing the number of pores in the material and their shape and size.

    The result of this study shows that the friction coefficient decreases with increasing density. The wear coefficient show signs of the same correlations but further tests are needed. The main wear comes from adhesive wear, with signs of abrasive wear. The amount of abrasive wear seems to increase with an increase in density, supporting previous studies claiming that pores can trap wear debris and decrease the number of abrasive particles in the contact.

  • Persson, Tove
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Bergmark, Linnea
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Uttalet är toppen… av ett isberg: En kvalitativ studie om klasslärare, speciallärare och specialpedagogers arbete med elever som har en språkstörning.2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Diagnosen språkstörning hos barn är något som ofta försummas på de svenska skolorna och okunskapen kring ämnet, trots att diagnosen är så pass vanlig, är fortfarande väldigt stor. Studien belyser hur arbetet kring elever med språkstörning ser ut idag på skolor runt om i Mellansverige och även hur pedagoger reflekterar kring arbetet med dessa elever. Studien genomsyras av Lev Vygotskijs sociokulturella teori som även den svenska läroplanen lutar sig på idag. I studien utfördes sju kvalitativa intervjuer med lärare, speciallärare och en specialpedagog som arbetar med elever och lärare i årskurserna F-6 i olika kommuner i Mellansverige. Intervjumaterialet analyserades med färgteman och utgjorde resultatet. Resultatet visar att bildstöd, struktur och samarbete mellan lärare, speciallärare och specialpedagog är viktigt för ett optimalt lärande för elever med diagnostiserad språkstörning. Resultatet visar även en upplevd okunskap hos klasslärare om elever med diagnostiserad språkstörning som i sin tur kan leda till dåliga förutsättningar för elever med diagnostiserad språkstörning.

  • Rees, Rhianna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Seaweed is Sexy: The consumption and utilisation of seaweed throughout British history and the marketing that surrounds it2019Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Damp, rotting, smelly, rising from the depths, washed up on shorelines. Seaweed (or Macroalgae) has transitioned over time in its position and uses within the British Isles; as discussed in the thesis it has undergone an evolution from its historical use as a source of food in times of desperation, to the superfood it is lauded as today. Other applications, from medicinal to agricultural, have contributed to a narrative of seaweed’s identity over the centuries, to the appeal of seaweed as a food source in the present day. There is an increased interest in seaweed, especially for culinary purposes, in the British Isles. Research by chefs, cookbooks and innovative product ranges also frame the current attitudes in the use of seaweed in common everyday foods. The case study shows the challenges and opportunities in the current revitalised seaweed market, identifying marketing analysis approaches useful for changing the attitudes toward seaweed in the British Isles. Based on interviews with companies marketing seaweed, and a focus on Seagreens®, I draw on advertising theory and consultancy tools (such as SWOT, AGCC, ELM and DAGMAR) to analyse the current seaweed market defining what I call a ‘consumer triad’ of potential consumers. Findings indicate many possibilities for future USP endorsements depending on the target market, from health-orientated to sustainably farmed. Seaweed interest appears to be more knowledge than consumer driven, so the question instead surrounds the prospect of knowledge sharing in an integrated online manner. Meanwhile, challenges in farming, labelling and conservation within the EU hamper advancements in the field, with the balance shifting to invested interest in Blue Economy models and IMTA systems.

  • Wang, Shunguo
    et al.
    Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
    Bastani, Mehrdad
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics. Geol Survey Sweden, SE-75236 Uppsala, Sweden.
    Constable, Steven
    Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
    Kalscheuer, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Malehmir, Alireza
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Boat-towed radio-magnetotelluric and controlled source audio-magnetotelluric study to resolve fracture zones at Äspö Hard Rock Laboratory site, Sweden2019In: Geophysical Journal International, ISSN 0956-540X, E-ISSN 1365-246X, Vol. 218, no 2, p. 1008-1031Article in journal (Refereed)
    Abstract [en]

    Boat-towed radio-magnetotelluric (RMT) measurements using signals between 14 and 250 kHz have attracted increasing attention in the near-surface applications for shallow water and archipelago areas. A few large-scale underground infrastructure projects, such as the Stockholm bypass in Sweden, are planned to pass underneath such water zones. However, in cases with high water salinity, RMT signals have a penetration depth of a few metres and do not reach the geological structures of interest in the underlying sediments and bedrock. To overcome this problem, controlled source signals at lower frequencies of 1.25 to 12.5 kHz can be utilized to improve the penetration depth and to enhance the resolution for modelling deeper underwater structures. Joint utilization of boat-towed RMT and controlled source audio-magnetotellurics (CSAMT) was tested for the first time at the Aspo Hard Rock Laboratory (HRL) site in south-eastern Sweden to demonstrate acquisition efficiency and improved resolution to model fracture zones along a 600-m long profile. Pronounced galvanic distortion effects observed in 1-D inversion models of the CSAMT data as well as the predominantly 2-D geological structures at this site motivated usage of 2-D inversion. Two standard academic inversion codes, EMILIA and MARE2DEM, were used to invert the RMT and CSAMT data. EMILIA, an object-oriented Gauss-Newton inversion code with modules for 2-D finite difference and 1-D semi-analytical solutions, was used to invert the RMT and CSAMT data separately and jointly under the plane-wave approximation for 2-D models. MARE2DEM, a Gauss-Newton inversion code for controlled source electromagnetic 2.5-D finite element solution, was modified to allow for inversions of RMT and CSAMT data accounting for source effects. Results of EMILIA and MARE2DEM reveal the previously known fracture zones in the models. The 2-D joint inversions of RMT and CSAMT data carried out with EMILIA and MARE2DEM show clear improvement compared with 2-D single inversions, especially in imaging uncertain fracture zones analysed in a previous study. Our results show that boat-towed RMT and CSAMT data acquisition systems can be utilized for detailed 2-D or 3-D surveys to characterize near-surface structures underneath shallow water areas. Potential future applications may include geo-engineering, geohazard investigations and mineral exploration.

  • Caramori, Stefano
    et al.
    Univ Ferrara, Dept Chem & Pharmaceut Sci, Ferrara, Italy.
    Freitag, Marina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Pastore, Mariachiara
    Univ Lorraine, Lab Phys & Chim Theor, Nancy, France;CNRS, Nancy, France.
    Editorial: Photoactive Interfaces for Solar Energy Conversion2019In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 7, article id 492Article in journal (Other academic)
  • Frisk, Sofia
    et al.
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Karolinska Univ Lab, Dept Clin Genet, Stockholm, Sweden.
    Taylan, Fulya
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden.
    Blaszczyk, Izabela
    Umea Univ Hosp, Dept Surg & Perioperat Sci, Hand & Plast Surg, Umea, Sweden.
    Nennesmo, Inger
    Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden.
    Annerén, Göran
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Herm, Bettina
    Ostersunds Hosp, Child & Adolescent Habilitat Ctr, Ostersund, Sweden.
    Stattin, Evalena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Zachariadis, Vasilios
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden.
    Lindstrand, Anna
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Karolinska Univ Lab, Dept Clin Genet, Stockholm, Sweden.
    Tesi, Bianca
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Karolinska Univ Lab, Dept Clin Genet, Stockholm, Sweden.
    Laurell, Tobias
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden.
    Nordgren, Ann
    Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Karolinska Univ Lab, Dept Clin Genet, Stockholm, Sweden.
    Early activating somatic PIK3CA mutations promote ectopic muscle development and upper limb overgrowth2019In: Clinical Genetics, ISSN 0009-9163, E-ISSN 1399-0004, Vol. 96, no 2, p. 118-125Article in journal (Refereed)
    Abstract [en]

    PIK3CA-related overgrowth spectrum is a group of rare genetic disorders with asymmetric overgrowth caused by somatic mosaic PIK3CA mutations. Here, we report clinical data and molecular findings from two patients with congenital muscular upper limb overgrowth and aberrant anatomy. During debulking surgery, numerous ectopic muscles were found in the upper limbs of the patients. DNA sequencing, followed by digital polymerase chain reaction, was performed on DNA extracted from biopsies from hypertrophic ectopic muscles and identified the somatic mosaic PIK3CA hotspot mutations c.3140A > G, p.(His1047Arg) and c.1624G > A, p.(Glu542Lys) in a male (patient 1) and a female (patient 2) patient, respectively. Patient 1 had four ectopic muscles and unilateral isolated muscular overgrowth while patient 2 had 13 ectopic muscles and bilateral isolated muscular overgrowth of both upper limbs, indicating that her mutation occurred at early pre-somitic mesoderm state. The finding of PIK3CA mutations in ectopic muscles highlights the importance of PIK3CA in cell fate in early human embryonic development. Moreover, our findings provide evidence that the disease phenotype depends on the timing of PIK3CA mutagenesis during embryogenesis and confirm the diagnostic entity PIK3CA-related muscular overgrowth with ectopic accessory muscles.

  • Duffy, J. Emmett
    et al.
    Smithsonian Inst, Edgewater, MD 21037 USA.
    Benedetti-Cecchi, Lisandro
    Univ Pisa, Dept Biol, Pisa, Italy;CoNISMa, Pisa, Italy.
    Trinanes, Joaquin
    Univ Santiago de Compostela, Inst Invest Tecnolox, Santiago, Spain;NOAA, Phys Oceanog Div, Atlantic Oceanog & Meteorol Lab, Miami, FL USA;Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Cooperat Inst Marine & Atmospher Studies, 4600 Rickenbacker Causeway, Miami, FL 33149 USA.
    Muller-Karger, Frank E.
    Univ S Florida, Coll Marine Sci, St Petersburg, FL USA.
    Ambo-Rappe, Rohani
    Hasanuddin Univ, Dept Marine Sci, Makassar, Indonesia.
    Boström, Christoffer
    Abo Akad Univ, Fac Sci & Engn, Environm & Marine Biol, Turku, Finland.
    Buschmann, Alejandro H.
    Univ Los Lagos, Ctr I Mar, Puerto Montt, Chile;Univ Los Lagos, Ctr Biotecnol & Bioingn CeBiB, Puerto Montt, Chile.
    Byrnes, Jarrett
    Univ Massachusetts, Dept Biol, Boston, MA 02125 USA.
    Coles, Robert G.
    James Cook Univ, Ctr Trop Water & Aquat Ecosyst Res, Douglas, Qld, Australia.
    Creed, Joel
    Univ Estado Rio de Janeiro, Dept Ecol, Rio De Janeiro, Brazil.
    Cullen-Unsworth, Leanne C.
    Cardiff Univ, Sustainable Pl Res Inst, Cardiff, S Glam, Wales.
    Diaz-Pulido, Guillermo
    Griffith Univ, Sch Environm & Sci, Brisbane, Qld, Australia;Griffith Univ, Australian Rivers Inst Coast & Estuaries, Brisbane, Qld, Australia.
    Duarte, Carlos M.
    King Abdullah Univ Sci & Technol, Red Sea Res Ctr, Thuwal, Saudi Arabia.
    Edgar, Graham J.
    Univ Tasmania, Hobart, Tas, Australia.
    Fortes, Miguel
    Univ Philippines, Marine Sci Inst CS, Quezon City, Philippines.
    Goni, Gustavo
    NOAA, Atlantic Oceanog & Meteorol Lab, Miami, FL 33149 USA.
    Hu, Chuanmin
    Univ S Florida, Coll Marine Sci, St Petersburg, FL USA.
    Huang, Xiaoping
    Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China.
    Hurd, Catriona L.
    Univ Tasmania, Inst Marine & Antarctic Studies, Hobart, Tas, Australia.
    Johnson, Craig
    Univ Tasmania, Hobart, Tas, Australia.
    Konar, Brenda
    Univ Alaska Fairbanks, Coll Fisheries & Ocean Sci, Fairbanks, AK USA.
    Krause-Jensen, Dorte
    Aarhus Univ, Dept Biosci, Silkeborg, Denmark;Aarhus Univ, Arctic Res Ctr, Aarhus, Denmark.
    Krumhansl, Kira
    Bedford Inst Oceanog, Dartmouth, NS, Canada.
    Macreadie, Peter
    Deakin Univ, Ctr Integrat Ecol, Burwood, Vic, Australia.
    Marsh, Helene
    James Cook Univ, Div Trop Environm & Soc, Townsville, Qld, Australia.
    McKenzie, Len J.
    James Cook Univ, Ctr Trop Water & Aquat Ecosyst Res, Douglas, Qld, Australia.
    Mieszkowska, Nova
    Marine Biol Assoc UK, Plymouth, Devon, England.
    Miloslavich, Patricia
    Univ Tasmania, Inst Marine & Antarctic Studies, Hobart, Tas, Australia;Univ Simon Bolivar, Dept Estudios Ambientales, Caracas, Venezuela.
    Montes, Enrique
    Univ S Florida, Coll Marine Sci, St Petersburg, FL USA.
    Nakaoka, Masahiro
    Hokkaido Univ, Akkeshi Marine Stn, Field Sci Ctr Northern Biosphere, Sapporo, Hokkaido, Japan.
    Norderhaug, Kjell Magnus
    IMR, Bergen, Norway.
    Nordlund, Lina M.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development.
    Orth, Robert J.
    Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA.
    Prathep, Anchana
    Pince Songkla Univ, Fac Sci, Dept Biol, Hat Yai, Thailand.
    Putman, Nathan F.
    LGL Ecol Res Associates, Bryan, TX USA.
    Samper-Villarreal, Jimena
    Univ Costa Rica, Ctr Invest Ciencias Mar & Limnol, San Jose, CA USA.
    Serrao, Ester A.
    Univ Algarve, Ctr Marine Sci CCMAR, Interdisciplinary Ctr Marine & Environm Res CIMAR, Faro, Portugal.
    Short, Frederick
    Univ New Hampshire, Nat Resources & Environm, Durham, NH 03824 USA.
    Pinto, Isabel Sousa
    Univ Porto, Fac Sci, Interdisciplinary Ctr Marine & Environm Res CIIMA, Porto, Portugal.
    Steinberg, Peter
    Sydney Inst Marine Sci, Mosman, NSW, Australia.
    Stuart-Smith, Rick
    Univ Tasmania, Hobart, Tas, Australia.
    Unsworth, Richard K. F.
    Swansea Univ, Seagrass Ecosyst Res Grp, Swansea, W Glam, Wales.
    van Keulen, Mike
    Murdoch Univ, Ctr Sustainable Aquat Ecosyst Environm & Conserva, Murdoch, WA, Australia.
    van Tussenbroek, Brigitta, I
    Univ Nacl Autonoma Mexico, ICML, Puerto Morelos, Mexico.
    Wang, Mengqiu
    Univ S Florida, Coll Marine Sci, St Petersburg, FL USA.
    Waycott, Michelle
    Univ Adelaide, Dept Environm & Water, Adelaide, SA, Australia;State Herbarium South Australia, Adelaide, SA, Australia.
    Weatherdon, Lauren, V
    UN Environm World Conservat Monitoring Ctr, Cambridge, England.
    Wernberg, Thomas
    Univ Western Australia, Oceans Inst, Perth, WA, Australia;Univ Western Australia, Sch Biol Sci, Perth, WA, Australia.
    Yaakub, Siti Maryam
    DHI Water & Environm, Ecol Habitats & Proc Dept, Singapore, Singapore.
    Toward a Coordinated Global Observing System for Seagrasses and Marine Macroalgae2019In: Frontiers in Marine Science, E-ISSN 2296-7745, Vol. 6, article id 317Article, review/survey (Refereed)
    Abstract [en]

    In coastal waters around the world, the dominant primary producers are benthic macrophytes, including seagrasses and macroalgae, that provide habitat structure and food for diverse and abundant biological communities and drive ecosystem processes. Seagrass meadows and macroalgal forests play key roles for coastal societies, contributing to fishery yields, storm protection, biogeochemical cycling and storage, and important cultural values. These socio-economically valuable services are threatened worldwide by human activities, with substantial areas of seagrass and macroalgal forests lost over the last half-century. Tracking the status and trends in marine macrophyte cover and quality is an emerging priority for ocean and coastal management, but doing so has been challenged by limited coordination across the numerous efforts to monitor macrophytes, which vary widely in goals, methodologies, scales, capacity, governance approaches, and data availability. Here, we present a consensus assessment and recommendations on the current state of and opportunities for advancing global marine macrophyte observations, integrating contributions from a community of researchers with broad geographic and disciplinary expertise. With the increasing scale of human impacts, the time is ripe to harmonize marine macrophyte observations by building on existing networks and identifying a core set of common metrics and approaches in sampling design, field measurements, governance, capacity building, and data management. We recommend a tiered observation system, with improvement of remote sensing and remote underwater imaging to expand capacity to capture broad-scale extent at intervals of several years, coordinated with strati fied in situ sampling annually to characterize the key variables of cover and taxonomic or functional group composition, and to provide ground-truth. A robust networked system of macrophyte observations will be facilitated by establishing best practices, including standard protocols, documentation, and sharing of resources at all stages of work flow, and secure archiving of open-access data. Because such a network is necessarily distributed, sustaining it depends on close engagement of local stakeholders and focusing on building and long-term maintenance of local capacity, particularly in the developing world. Realizing these recommendations will producemore effective, efficient, and responsive observing, a more accurate global picture of change in vegetated coastal systems, and stronger international capacity for sustaining observations.

  • Bahram, Mohammad
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. Univ Tartu, Inst Ecol & Earth Sci, Dept Bot, 40 Lai St, Tartu, Estonia;Swedish Univ Agr Sci, Dept Ecol, Ulls Vag 16, S-75651 Uppsala, Sweden.
    Anslan, Sten
    Univ Tartu, Inst Ecol & Earth Sci, Dept Bot, 40 Lai St, Tartu, Estonia;Braunschweig Univ Technol, Zool Inst, Mendelssohnstr 4, D-38106 Braunschweig, Germany.
    Hildebrand, Falk
    European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany.
    Bork, Peer
    European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany;Max Delbruck Ctr Mol Med, Berlin, Germany;Univ Wurzburg, Bioctr, Dept Bioinformat, Wurzburg, Germany.
    Tedersoo, Leho
    Univ Tartu, Nat Hist Museum, 14A Ravila, EE-50411 Tartu, Estonia.
    Newly designed 16S rRNA metabarcoding primers amplify diverse and novel archaeal taxa from the environment2019In: Environmental Microbiology Reports, ISSN 1758-2229, E-ISSN 1758-2229, Vol. 11, no 4, p. 487-494Article in journal (Refereed)
    Abstract [en]

    High-throughput studies of microbial communities suggest that Archaea are a widespread component of microbial diversity in various ecosystems. However, proper quantification of archaeal diversity and community ecology remains limited, as sequence coverage of Archaea is usually low owing to the inability of available prokaryotic primers to efficiently amplify archaeal compared to bacterial rRNA genes. To improve identification and quantification of Archaea, we designed and validated the utility of several primer pairs to efficiently amplify archaeal 16S rRNA genes based on up-to-date reference genes. We demonstrate that several of these primer pairs amplify phylogenetically diverse Archaea with high sequencing coverage, outperforming commonly used primers. Based on comparing the resulting long 16S rRNA gene fragments with public databases from all habitats, we found several novel family- to phylum-level archaeal taxa from topsoil and surface water. Our results suggest that archaeal diversity has been largely overlooked due to the limitations of available primers, and that improved primer pairs enable to estimate archaeal diversity more accurately.

  • Hassan, Nesrin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Kurderna mellan förtryck och kamp: Jämförelse av Turkiets och Syriens behandling av kurderna2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Armaki, Shamin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Exploring the realm of culture within management: The effects of fully integrated relocation services on cross-cultural learning and adjustment2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Expatriates’ adjustment to the host-country culture is a dynamic and gradual process. This process can be facilitated by cross-cultural training. The relationship between cross-cultural training and crosscultural adjustment has been explored to a great extent in the literature, however scholars have mainly put focus on how this relationship unfolds in the context of MNCs offering CCT in-house. Consequently, this leaves an interesting uninvestigated gap in terms of how fully integrated relocation service companies work with cross-cultural services and how their work can facilitate cross-cultural adjustment. This qualitative case-study therefore aims to examine the relationship between crosscultural training provided by a relocation service company and the expatriate adjustment process. An extensive review on existing theories concerning cross-cultural adjustment, cross-cultural training and cross-cultural learning are presented. After this, the case study examines how Nordic Relocation Group (NRG), a relocation service company in Sweden, operates in terms of providing cross-cultural services.

    The findings indicate that the relocation service company’s services are divided into different phases, whereby the timing and content of services offered varies as the expatriates’ international assignment develops over time. This form of tailoring the cross-cultural training and the content of their services supports the notion of sequential training, which within IHRM literature, is proposed as optimal in order to facilitate the expatriate’s adjustment process. Moreover, the results further indicate that the way in which NRG works with cross-cultural services, in terms of strategy, sequential order, and specific CCT activities offered, promotes effective cross-cultural learning. Consequently, the CCT strategies offered by the relocation service company can be viewed as being aligned with best practice.

  • Bergfelt, Emma
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Karlsson, Karin
    Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden.
    Ahlberg, Lucia
    Univ Hosp Linkoping, Dept Haematol, Linkoping, Sweden.
    Garelius, Hege
    Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden.
    Hulegardh, Erik
    Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden.
    Izarra, Antonio S.
    Univ Hosp Umea, Ctr Canc, Dept Haematol, Umea, Sweden.
    Joelsson, Joel
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Div Haematol, Stockholm, Sweden.
    Kozlowski, Piotr
    Orebro Univ, Sch Med Sci, Dept Med, Orebro, Sweden.
    Moicean, Andreea
    Cent Hosp Skovde, Dept Med, Skovde, Sweden.
    Tomaszewska-Toporska, Beata
    Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden.
    Lubking, Anna
    Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden.
    Hallböök, Helene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry2019In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 103, no 2, p. 88-98Article in journal (Refereed)
    Abstract [en]

    Objectives: As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care.

    Methods: We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 and 2015.

    Results: The median age was 53 years. The frequency of Philadelphia (Ph)-positive leukaemia was 34% of examined B-ALL with a peak incidence at 50-59 years. Five-year overall survival (OS) improved between 1997-2006 and 2007-2015; in patients 18-45 years from 50% (95% CI 43-57) to 65% (95% CI 58-72), 46-65 years from 25% (95% CI 18-32) to 46% (95% CI 37-55) and >65 years from 7% (95% CI 2.6-11) to 11% (95% CI 5.9-16) (P < 0.05). Men with Ph-neg B-ALL 46-65 years had inferior OS compared with women (P < 0.01). Standardised mortality ratio was 5.7 (95% CI 5.0-6.3) for patients who survived 5 years from diagnosis. In multivariable analysis, Ph-positive disease was not associated with impaired prognosis but with lower risk of death in 2007-2015.

    Conclusions: In a population-based cohort, OS has improved in adult ALL, especially for Ph-positive disease but for middle-aged men with Ph-negative B-ALL outcome was poor. Cure without late toxicity or relapse is still desired.

  • Selin, Lotta
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Hlth & Care Sci, S-40530 Gothenburg, Sweden;NU Hosp Grp, Dept Obstet & Gynecol, Trollhattan, Sweden.
    Wennerholm, Ulla-Britt
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden.
    Jonsson, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Obstetrics.
    Dencker, Anna
    Univ Gothenburg, Sahlgrenska Acad, Inst Hlth & Care Sci, S-40530 Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Ctr Person Ctr Care, Gothenburg, Sweden.
    Wallin, Gunnar
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden.
    Wiberg-Itzel, Eva
    Karolinska Inst, Soder Hosp, Sect Obstet & Gynaecol, Dept Clin Sci & Educ, Stockholm, Sweden.
    Almström, Elisabeth
    NU Hosp Grp, Dept Obstet & Gynecol, Trollhattan, Sweden.
    Petzold, Max
    Univ Gothenburg, Sahlgrenska Acad, Hlth Metr Unit, Gothenmurg, Sweden.
    Berg, Marie
    Univ Gothenburg, Sahlgrenska Acad, Inst Hlth & Care Sci, S-40530 Gothenburg, Sweden;Sahlgrens Univ Hosp, Obstet Unit, Gothenburg, Sweden.
    High-dose versus low-dose of oxytocin for labour augmentation: a randomised controlled trial2019In: Women and Birth, ISSN 1871-5192, E-ISSN 1878-1799, Vol. 32, no 4, p. 356-363Article in journal (Refereed)
    Abstract [en]

    Problem: Delayed labour progress is common in nulliparous women, often leading to caesarean section despite augmentation of labour with synthetic oxytocin.

    Background: High-or low-dose oxytocin can be used for augmentation of delayed labour, but evidence for promoting high-dose is weak.

    Aim: To ascertain the effect on caesarean section rate of high-dose versus low-dose oxytocin for augmentation of delayed labour in nulliparous women.

    Methods: Multicentre parallel double-blind randomised controlled trial (ClinicalTrials.gov: NCT01587625) in six labour wards in Sweden. Healthy nulliparous women at term with singleton cephalic fetal presentation, spontaneous labour onset, confirmed delay in labour and ruptured membranes (n = 1351) were randomised to labour augmentation with either high-dose (6.6 mU/minute) or low-dose (3.3 mU/minute) oxytocin infusion.

    Findings: 1295 women were included in intention-to-treat analysis (high-dose n = 647; low-dose n = 648). Caesarean section rates did not differ between groups (12.4% and 12.3%, 95% Confidence Interval -3.7 to 3.8). Women with high-dose oxytocin had: shorter labours (-23.4 min); more uterine tachysystole (43.2% versus 33.5%); similar rates of instrumental vaginal births, with more due to fetal distress (43.8% versus 22.7%) and fewer due to failure to progress (39.6% versus 58.8%). There were no differences in neonatal outcomes.

    Discussion: Our study could not confirm results of two systematic reviews indicating, with weak evidence, that use of high-dose oxytocin was associated with lower frequency of caesarean section.

    Conclusion: We found no advantages for routine use of high-dose oxytocin in the management of delay in labour. Low-dose oxytocin regimen is recommended to avoid unnecessary events of tachysystole and fetal distress. 

  • Wahlstein, Ivar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Soffliggare på jobbet: En kvantitativ studie om ickevals-alternativen i de fyra stora avtalsområdena inom den kollektivavtalade tjänstepensionen2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Occupational pension is an important part of an individual’s pension and projections showthat it will make up an increasingly larger part of the total pension. Despite its increasingimportance, the knowledge regarding occupational pension is low. Each occupational pensionagreement has a default alternative where the savings of the people who do not make a choiceof their own, the idlers, end up in.

    This thesis examines if and what differences exist between default alternatives in the four largest occupational pension agreements: ITP, PA 16, AKAP-KL/KAP-KL and SAF-LO. The examined differences are the yearly returns and the value increase it results in during theperiod 2008-2019, risk in terms of standard deviation and sensitivity to changes in the market(Beta), Sharpe ratio and Jensen’s alpha.

    The result shows that there is significant economical differences in all of the performance measures that are examined. Any statistical significant differences in the average return and differences in Jensen’s alpha when beta is controlled for was not found.

  • Kolundzic, Nikola
    et al.
    Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Stem Cell Lab,Dept Women & Childrens Hlth, London, England;Guys Hosp, Assisted Concept Unit, London, England.
    Khurana, Preeti
    Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Stem Cell Lab,Dept Women & Childrens Hlth, London, England;Guys Hosp, Assisted Concept Unit, London, England.
    Hobbs, Carl
    Kings Coll London, Wolfson Ctr Age Related Dis, Sch Biomed Sci, Histol Lab, London, England.
    Rogar, Marija
    Univ Ljubljana, Fac Med, Med Ctr Mol Biol, Ljubljana, Slovenia;AdriaBio Doo, Postojna, Slovenia.
    Ropret, Sandra
    Univ Ljubljana, Fac Med, Med Ctr Mol Biol, Ljubljana, Slovenia.
    Törmä, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
    Ilic, Dusko
    Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Stem Cell Lab,Dept Women & Childrens Hlth, London, England;Guys Hosp, Assisted Concept Unit, London, England.
    Liovic, Mirjana
    Univ Ljubljana, Fac Med, Med Ctr Mol Biol, Ljubljana, Slovenia.
    Induced pluripotent stem cell (iPSC) line from an epidermolysis bullosa simplex patient heterozygous for keratin 5 E475G mutation and with the Dowling Meara phenotype2019In: Stem Cell Research, ISSN 1873-5061, E-ISSN 1876-7753, Vol. 37, article id 101424Article in journal (Refereed)
    Abstract [en]

    We have generated MLi002-A, a new induced pluripotent stem cell (iPSC) line derived from keratinocytes of a skin punch biopsy of a female patient with the severe epidermolysis bullosa simplex Dowling-Meara phenotype and the keratin K5 E475G mutation. Keratinocytes were reprogrammed using non-integrating Sendai virus vectors, and xeno-free culture conditions were used throughout. The characterization of MLi002-A cell line consisted of molecular karyotyping, mutation screening using restriction enzyme digestion and Sanger sequencing, and testing of the pluripotency and differentiation potentials by immunofluorescence of associated markers both in vitro and in vivo. This is the first iPSC model of EB Simplex.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael U. F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Performance of top-quark and W-boson tagging with ATLAS in Run 2 of the LHC2019In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 79, no 5, article id 375Article in journal (Refereed)
    Abstract [en]

    The performance of identification algorithms (taggers) for hadronically decaying top quarks and W bosons in pp collisions at = 13TeV recorded by the ATLAS experiment at the Large Hadron Collider is presented. A set of techniques based on jet shape observables are studied to determine a set of optimal cut-based taggers for use in physics analyses. The studies are extended to assess the utility of combinations of substructure observables as a multivariate tagger using boosted decision trees or deep neural networks in comparison with taggers based on two-variable combinations. In addition, for highly boosted top-quark tagging, a deep neural network based on jet constituent inputs as well as a re-optimisation of the shower deconstruction technique is presented. The performance of these taggers is studied in data collected during 2015 and 2016 corresponding to 36.1fb-1 for the tt and +jet and 36.7-1 for the dijet event topologies.

  • Public defence: 2019-09-06 13:15 Polhemsalen, Uppsala
    Wen, Chenyu
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Solid-State Nanopores for Sensing: From Theory to Applications2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Nanopore based sensing technology has been widely studied for a broad range of applications including DNA sequencing, protein profiling, metabolite molecules, and ions detection. The nanopore technology offers an unprecedented technological solution to meeting the demands of precision medicine on rapid, in-field, and low-cost biomolecule analysis. In general, nanopores are categorized in two families: solid-state nanopore (SSNP) and biological nanopore. The former is formed in a solid-state membrane made of SiNx, SiO2, silicon, graphene, MoS2, etc., while the latter represents natural protein ion-channels in cell membranes. Compared to biological pores, SSNPs are mechanically robust and their fabrication is compatible with traditional semiconductor processes, which may pave the way to their large-scale fabrication and high-density integration with standard control electronics. However, challenges remain for SSNPs, including poor stability, low repeatability, and relatively high background noise level. This thesis explores SSNPs from basic physical mechanisms to versatile applications, by entailing a balance between theory and experiment.

    The thesis starts with theoretical models of nanopores. First, resistance of the open pore state is studied based on the distribution of electric field. An important concept, effective transport length, is introduced to quantify the extent of the high field region. Based on this conductance model, the nanopores size of various geometrical shapes can be extracted from a simple resistance measurement. Second, the physical causality of ionic current rectification of geometrically asymmetrical nanopores is unveiled. Third, the origin of low-frequency noise is identified. The contribution of each noise component at different conditions is compared. Forth, a simple nano-disk model is used to describe the blockage of ionic current caused by DNA translocation. The signal and noise properties are analyzed at system level.

    Then, nanopore sensing experiments are implemented on cylinder SiNx nanopores and truncated-pyramid silicon nanopores (TPP). Prior to a systematic study, a low noise electrical characterization platform for nanopore devices is established. Signal acquisition guidelines and data processing flow are standardized. The effects of electroosmotic vortex in TPP on protein translocation dynamics are excavated. The autogenic translocation of DNA and proteins driven by the pW-level power generated by an electrolyte concentration gradient is demonstrated. Furthermore, by extending to a multiple pore system, the group translocation behavior of nanoparticles is studied. Various application scenarios, different analyte categories and divergent device structures accompanying with flexible configurations clearly point to the tremendous potential of SSNPs as a versatile sensor.

    List of papers
    1. Physical Model for Rapid and Accurate Determination of Nanopore Size via Conductance Measurement
    Open this publication in new window or tab >>Physical Model for Rapid and Accurate Determination of Nanopore Size via Conductance Measurement
    2017 (English)In: ACS SENSORS, ISSN 2379-3694, Vol. 2, no 10, p. 1523-1530Article in journal (Refereed) Published
    Abstract [en]

    Nanopores have been explored for various biochemical and nanoparticle analyses, primarily via characterizing the ionic current through the pores. At present, however, size determination for solid-state nanopores is experimentally tedious and theoretically unaccountable. Here, we establish a physical model by introducing an effective transport length, L (eff) that measures, for a symmetric nanopore, twice the distance from the center of the nanopore where the electric field is the highest to the point along the nanopore axis where the electric field falls to e-(1)of this maximum. By G = sigma(s0)/L-eff, a simple expression S-0=/(G, sigma, h, beta) is derived to algebraically correlate minimum nanopore cross-section area S (0)to nanopore conductance G, electrolyte conductivity a, and membrane thickness h with (3 to denote pore shape that is determined by the pore fabrication technique. The model agrees excellently with experimental results for nanopores in graphene, single-layer MoS2, and ultrathin SiNx films. The generality of the model is verified by applying it to micrometer-size pores.

    Keywords
    nanopores, physical model, effective transport length, algebraic solution, conductance measurement in electrolyte
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-340952 (URN)10.1021/acssensors.7b00576 (DOI)000414238600021 ()28974095 (PubMedID)
    Funder
    Swedish Research Council, 621-2014-6300
    Available from: 2018-02-13 Created: 2018-02-13 Last updated: 2019-06-19Bibliographically approved
    2. Zero-Depth Interfacial Nanopore Capillaries
    Open this publication in new window or tab >>Zero-Depth Interfacial Nanopore Capillaries
    Show others...
    2018 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 9, article id 1703602Article in journal (Refereed) Published
    Abstract [en]

    High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, nanocapillaries of zero depth are formed by dissolving two superimposed and crossing metallic nanorods, molded in polymeric slabs. In an electrolyte, the interface shared by the crossing fluidic channels is mathematically of zero thickness and defines the narrowest constriction in the stream of ions through the nanopore device. This novel architecture provides the possibility to design nanopore fluidic channels, particularly with a robust 3D architecture maintaining the ultimate zero thickness geometry independently of the thickness of the fluidic channels. With orders of magnitude reduced biomolecule translocation speed, and lowered electronic and ionic noise compared to nanopores in 2D materials, the findings establish interfacial nanopores as a scalable platform for realizing nanofluidic systems, capable of single-molecule detection.

    Place, publisher, year, edition, pages
    WILEY-V C H VERLAG GMBH, 2018
    Keywords
    2D nanopores, biomolecules, 1, f noise, mechanical stability, translocation speed
    National Category
    Condensed Matter Physics Atom and Molecular Physics and Optics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-350489 (URN)10.1002/adma.201703602 (DOI)000426491600035 ()
    Funder
    Swedish Research Council, 621-2014-6300]EU, European Research Council, 335879
    Available from: 2018-05-09 Created: 2018-05-09 Last updated: 2019-06-19Bibliographically approved
    3. On rectification of ionic current in nanopores
    Open this publication in new window or tab >>On rectification of ionic current in nanopores
    Show others...
    2019 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882Article in journal (Refereed) Submitted
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-384653 (URN)
    Available from: 2019-06-07 Created: 2019-06-07 Last updated: 2019-06-19
    4. Generalized Noise Study of Solid-State Nanopores at Low Frequencies
    Open this publication in new window or tab >>Generalized Noise Study of Solid-State Nanopores at Low Frequencies
    Show others...
    2017 (English)In: ACS Sensors, ISSN 2379-3694, Vol. 2, no 2, p. 300-307Article in journal (Refereed) Published
    Abstract [en]

    Nanopore technology has been extensively investigated for analysis of biomolecules, and a success story in this field concerns DNA sequencing using a nanopore chip featuring an array of hundreds of biological nanopores (BioNs). Solid-state nanopores (SSNs) have been explored to attain longer lifetime and higher integration density than what BioNs can offer, but SSNs are generally considered to generate higher noise whose origin remains to be confirmed. Here, we systematically study lowfrequency (including thermal and flicker) noise characteristics of SSNs measuring 7 to 200 nm in diameter drilled through a 20-nmthick SiNx membrane by focused ion milling. Both bulk and surface ionic currents in the nanopore are found to contribute to the flicker noise, with their respective contributions determined by salt concentration and pH in electrolytes as well as bias conditions. Increasing salt concentration at constant pH and voltage bias leads to increase in the bulk ionic current and noise therefrom. Changing pH at constant salt concentration and current bias results in variation of surface charge density, and hence alteration of surface ionic current and noise. In addition, the noise from Ag/AgCl electrodes can become predominant when the pore size is large and/or the salt concentration is high. Analysis of our comprehensive experimental results leads to the establishment of a generalized nanopore noise model. The model not only gives an excellent account of the experimental observations, but can also be used for evaluation of various noise components in much smaller nanopores currently not experimentally available.

    Keywords
    flicker noise, nanopore, electrical double layer, model, power spectrum density, low frequency range, Hooge’s theory
    National Category
    Other Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-315230 (URN)10.1021/acssensors.6b00826 (DOI)000395047000017 ()
    Funder
    Swedish Research Council, 621-2014-6300Stiftelsen Olle Engkvist Byggmästare, 2016/39Swedish Foundation for Strategic Research
    Note

    Chenyu Wen and Shuangshuang Zeng contributed equally to this work.

    Available from: 2017-02-10 Created: 2017-02-10 Last updated: 2019-06-19Bibliographically approved
    5. On nanopore DNA sequencing by signal and noise analysis of ionic current
    Open this publication in new window or tab >>On nanopore DNA sequencing by signal and noise analysis of ionic current
    Show others...
    2016 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 27, article id 215502Article in journal (Refereed) Published
    Abstract [en]

    DNA sequencing, i.e., the process of determining the succession of nucleotides on a DNA strand, has become a standard aid in biomedical research and is expected to revolutionize medicine. With the capability of handling single DNA molecules, nanopore technology holds high promises to become speedier in sequencing at lower cost than what are achievable with the commercially available optics-or semiconductor-based massively parallelized technologies. Despite tremendous progress made with biological and solid-state nanopores, high error rates and large uncertainties persist with the sequencing results. Here, we employ a nano-disk model to quantitatively analyze the sequencing process by examining the variations of ionic current when a DNA strand translocates a nanopore. Our focus is placed on signal-boosting and noise-suppressing strategies in order to attain the single-nucleotide resolution. Apart from decreasing pore diameter and thickness, it is crucial to also reduce the translocation speed and facilitate a stepwise translocation. Our best-case scenario analysis points to severe challenges with employing plain nanopore technology, i.e., without recourse to any signal amplification strategy, in achieving sequencing with the desired single-nucleotide resolution. A conceptual approach based on strand synthesis in the nanopore of the translocating DNA from single-stranded to double-stranded is shown to yield a 10-fold signal amplification. Although it involves no advanced physics and is very simple in mathematics, this simple model captures the essence of nanopore sequencing and is useful in guiding the design and operation of nanopore sequencing.

    Keywords
    nanopore; DNA sequencing; ionic current; model; series resistance; noise; signal
    National Category
    Other Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:uu:diva-295968 (URN)10.1088/0957-4484/27/21/215502 (DOI)000374507600013 ()27095148 (PubMedID)
    Funder
    Swedish Research Council, 621-2014-6300
    Available from: 2016-06-11 Created: 2016-06-11 Last updated: 2019-06-19Bibliographically approved
    6. Rectification of protein translocation in truncated-pyramidal nanopores caused by the formation of electroosmotic vortex
    Open this publication in new window or tab >>Rectification of protein translocation in truncated-pyramidal nanopores caused by the formation of electroosmotic vortex
    Show others...
    2019 (English)In: Nature Nanotechnology, ISSN 1748-3387, E-ISSN 1748-3395Article in journal (Refereed) Submitted
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-384656 (URN)
    Available from: 2019-06-07 Created: 2019-06-07 Last updated: 2019-06-19
    7. Autogenic analyte translocation in nanopores
    Open this publication in new window or tab >>Autogenic analyte translocation in nanopores
    Show others...
    2019 (English)In: Nano Energy, ISSN 2211-2855, E-ISSN 2211-3282, Vol. 60, p. 503-509Article in journal (Refereed) Published
    Abstract [en]

    Nanopores have been widely studied for power generation and single-molecule detection. Although the power level generated by a single nanopore based on electrolyte concentration gradient is too low to be practically useful, such a power level is found sufficient to drive analyte translocation in nanopores. Here, we explore the simultaneous action of a solid-state nanopore as a nanopower generator and a nanoscale biosensor by exploiting the extremely small power generated to drive the analyte translocation in the same nanopore device. This autogenic analyte translocation is demonstrated using protein and DNA for their distinct shape, size and charge. The simple device structure allows for easy implementation of either electrical or optical readout. The obtained nanopore translocation is characterized by typical behaviors expected for an ordinary nanopore sensor powered by an external source. Extensive numerical simulation confirms the power generation and power level generated. It also reveals the fundamentals of autogenic translocation. As it requires no external power source, the sensing can be conducted with simple readout electronics and may allow for integration of high-density nanopores. Our approach demonstrated in this work may pave the way to practical high-throughput single-molecule nanopore sensing powered by the distributed energy harvested by the nanopores themselves.

    Place, publisher, year, edition, pages
    Elsevier, 2019
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-384648 (URN)10.1016/j.nanoen.2019.03.092 (DOI)000467774100056 ()
    Funder
    Swedish Research Council, 621-2014-6300Stiftelsen Olle Engkvist Byggmästare, 2016/39
    Available from: 2019-06-07 Created: 2019-06-07 Last updated: 2019-06-19Bibliographically approved
    8. Group behavior of nanoparticles translocating multiple nanopores
    Open this publication in new window or tab >>Group behavior of nanoparticles translocating multiple nanopores
    2018 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 90, no 22, p. 13483-13490Article in journal (Refereed) Published
    Abstract [en]

    Nanopores have been implemented as nanosensors for DNA sequencing, biomolecule inspection, chemical analysis, nanoparticle detection, etc. For high-throughput and parallelized measurement using nanopore arrays, individual addressability has been a crucial technological solution in order to enable scrutiny of signals generated at each and every nanopore. Here, an alternative pathway of employing arrayed nanopores to perform sensor functions is investigated by examining the group behavior of nanoparticles translocating multiple nanopores. As no individual addressability is required, fabrication of nanopore devices along with microfluidic cells and readout circuits can be greatly simplified. Experimentally, arrays of less than 10 pores are shown to be capable of analyzing translocating nanoparticles with a good signal-to-noise margin. According to theoretical predictions, more pores (than 10) per array can perform high-fidelity analysis if the noise level of the measurement system can be better controlled. More pores per array would also allow for faster measurement at lower concentration because of larger capture cross sections for target nanoparticles. By experimentally varying the number of pores, the concentration of nanoparticles, or the applied bias voltage across the nanopores, we have identified the basic characteristics of this multievent process. By characterizing average pore current and associated standard deviation during translocation and by performing physical modeling and extensive numerical simulations, we have shown the possibility of determining the size and concentration of two kinds of translocating nanoparticles over 4 orders of magnitude in concentration. Hence, we have demonstrated the potential and versatility of the multiple-nanopore approach for high-throughput nanoparticle detection.

    Place, publisher, year, edition, pages
    Washington: American Chemical Society (ACS), 2018
    National Category
    Nano Technology
    Identifiers
    urn:nbn:se:uu:diva-369418 (URN)10.1021/acs.analchem.8b03408 (DOI)000451246100048 ()30372031 (PubMedID)
    Funder
    Swedish Research Council, 621-2014-6300Stiftelsen Olle Engkvist Byggmästare, 2016/39
    Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2019-06-19Bibliographically approved
  • Eriksson, Daniel
    et al.
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.
    Bacchetta, Rosa
    Stanford Univ, Dept Pediat, Sch Med, Div Stem Cell Transplantat & Regenerat Med, Stanford, CA 94305 USA.
    Gunnarsson, Hörður Ingi
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    Chan, Alice
    Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
    Barzaghi, Federica
    IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy, Pediat Immunohematol & Bone Marrow Transplantat U, Milan, Italy.
    Ehl, Stephan
    Univ Freiburg, Freiburg Univ Hosp, Ctr Chron Immunodeficiency, Fac Med, Freiburg, Germany.
    Hallgren, Åsa
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    van Gool, Frederic
    Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA.
    Sardh, Fabian
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    Lundqvist, Christina
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
    Laakso, Saila M.
    Univ Helsinki, Childrens Hosp, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland.
    Rönnblom, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Gastroenterology/Hepatology.
    Ekwall, Olov
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
    Mäkitie, Outi
    Univ Helsinki, Childrens Hosp, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden;Folkhalsan Inst Genet, Helsinki, Finland;Univ Helsinki, Helsinki, Finland.
    Bensing, Sophie
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Husebye, Eystein S.
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden;Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Med, Bergen, Norway;KG Jebsen Ctr Autoimmune Disorders, Bergen, Norway.
    Anderson, Mark
    Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA.
    Kämpe, Olle
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden;KG Jebsen Ctr Autoimmune Disorders, Bergen, Norway.
    Landegren, Nils
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    The autoimmune targets in IPEX are dominated by gut epithelial proteins2019In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 144, no 1, p. 327-330Article in journal (Other academic)
  • Lindgren, Oskar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    "Vad ska vi göra? Rädda klimatet!": En förklarande fallstudie av klimatstrejken i Sverige, initierad av Greta Thunberrg2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Klimatstrejken som genomfördes den 15 mars 2019 i Stockholm samlade över 15 000 individer. Aldrig tidigare har en proteströrelse bestående av så många unga fått så stort genomslag i Sverige. Med utgångspunkt i Social Movement Theory har denna undersökning som målsättning att förklara drivkrafterna bakom denna rörelse. Enligt denna teoribildning kan utvecklingen av en social rörelse förklaras utifrån samspelet av tre kontextuella faktorer. Dessa är: politiska möjligheter, mobiliseringsstrukturer och inramning av problemet. För att undersöka om detta gäller även för klimatstrejken i Sverige genomförs intervjuer med representanter från organisationer som varit delaktiga i mobiliseringen av rörelsen och individer som varit drivande i nätverket Fridays for Future. Dessa intervjuer kompletteras med resultat från en enkätundersökning som genomfördes under klimatstrejken 15 mars 2019 i Stockholm. Resultaten tyder på att de tre kontextuella faktorerna varit närvarande och underlättat mobiliseringen av rörelsen. Författaren drar slutsatsen att Greta Thunberg varit den politiska möjlighet som krävdes för en mobilisering och att inramningen av problemet varit avgörande för uppslutningen kring klimatstrejken.

  • Sanders, Donald B.
    et al.
    Duke Univ, Med Ctr, Box 3403, Durham, NC 27710 USA.
    Arimura, Kimiyoshi
    Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Neurol & Geriatr, Kagoshima, Japan.
    Cui, LiYing
    Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China.
    Ertas, Mustafa
    Istanbul Fac Med, Istanbul, Turkey.
    Farrugia, Maria Elena
    Inst Neurol Sci, Glasgow, Lanark, Scotland.
    Gilchrist, James
    Southern Illinois Univ, Sch Med, Springfield, IL USA.
    Kouyoumdjian, Joao Aris
    Fac Med Sao Jose Rio Preto FAMERP, Sao Paulo, Brazil.
    Padua, Luca
    Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Geriatr Neurosci & Orthopaed, Rome, Italy.
    Pitt, Matthew
    Great Ormond St Hosp Sick Children, Dept Clin Neurophysiol, London, England.
    Stålberg, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rostedt Punga: Clinical Neurophysiology.
    Guidelines for single fiber EMG2019In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 130, no 8, p. 1417-1439Article in journal (Refereed)
    Abstract [en]

    This document is the consensus of international experts on the current status of Single Fiber EMG (SFEMG)and the measurement of neuromuscular jitter with concentric needle electrodes (CNE - CN-jitter). The panel of authors was chosen based on their particular interests and previous publications within a specific area of SFEMG or CN-jitter. Each member of the panel was asked to submit a section on their particular area of interest and these submissions were circulated among the panel members for edits and comments. This process continued until a consensus was reached. Donald Sanders and Erik Stalberg then edited the final document.

  • Karlsson, Denice
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature, Rhetoric.
    Populistiska alternativ till konsensus och mittenpolitik: En analys av Sverigedemokraternas framgång och vänsterns möjligheter baserad på teorier av Chantal Mouffe2019Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [sv]

    Chantal Mouffe förklarar exkludering och demonisering av politiska partier som en kontraproduktiv strategi. När etablerade partier samlas kring en konsensus i mitten reduceras medborgarnas valmöjligheter och undergräver demokratin, menar Mouffe. Detta är exempel på politiska fenomen som enligt Mouffe leder till att högerpopulistiska partier gynnas, något som skett i flera Europeiska länder. Högerpopulistiska partier och rörelser växer på många håll i Europa och Mouffe menar att uppsvinget för högerpopulismen och den populistiska retoriken till stor del beror på de etablerade partiernas tillkortakommanden.

    Syftet med uppsatsen är att utifrån Mouffes teori, och med Sverige som exempel, förklara hur en svag regering och ett starkt högerpopulistiskt parti hänger ihop med oförmågan att tänka politiskt och reflektera över hur en vänstervriden populistisk motståndskraft skulle kunna se ut.

  • Hägerström, Emelie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Bråkmakare eller policyskapare?: En innehållsanalys av Gula västarnas uttalanden i två franska dagstidningar2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    When the French government decided to raise the fuel taxes hundreds of thousands of Frenchmen gathered to protest around the country, and the movement of the Yellow Vests was created. As the internal communication mainly took place over the internet, it allowed a leaderless structure where a large number of participants quickly mobilized. Researchers in the field of social movements argue that the formation of collective actions are fundamental for the survival of a movement. In this thesis, quotes from the Yellow Vests are studied as a form of opposition with the aim of investigating changes over time. By creating a tool of analyzing opposition from social movements, a quantitative content analysis is used to study 216 quotes of Yellow Vests in two French newspapers. The results imply that the news reporting of the Yellow describes the movement as having a relatively united external agenda with the desire to gain more direct influence over politics with the purpose of reducing the gap between the peopleand the elite. However, this agenda is given less attention as time passes. Instead, the focus shifts to dealing with questions about the use of violence and the role of leadership internally. This may indicate a weakening of the movement, yet there is still a maintenance of a strong willpower to continue mobilizing.

  • Johnsson, Emil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Nätverkstypers påverkan på socialt kapital och politisk tolerans bland ungdomar: En studie om hur horisontella och vertikala nätverk påverkar graden av socialt kapital samt politisk tolerans bland ungdomar2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Ring-Dimitriou, Susanne
    et al.
    Paris Lodron Univ, Dept Sport Sci & Kinesiol, A-5020 Salzburg, Austria;ECOG, B-1000 Brussels, Belgium.
    Krustrup, Peter
    Univ Southern Denmark, Dept Sports Sci & Clin Biomech, SDU Sport & Hlth Sci Cluster SHSC, DK-5000 Odense, Denmark.
    Coelho-E-Silva, Manuel J.
    Univ Coimbra, Fac Sport Sci & Phys Educ, P-3000 Coimbra, Portugal.
    Mota, Jorge
    Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, P-4000 Porto, Portugal.
    Seabra, Andera
    Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, P-4000 Porto, Portugal.
    Rego, Carla
    Univ Porto, Fac Med, Ctr Res Hlth Technol & Informat Syst CINTESIS, P-4000 Porto, Portugal.
    Mazur, Artur
    ECOG, B-1000 Brussels, Belgium;Univ Rzeszow, Dept Pediat, Clin Prov Hosp 2 Rzeszow, Fac Med, PL-35301 Rzeszow, Poland.
    Vlachopapadopoulou, Elpis
    ECOG, B-1000 Brussels, Belgium;Childrens Hosp P&A Kyriakou, Dept Endocrinol, Athens 10431, Greece.
    Caroli, Margerita
    ECOG, B-1000 Brussels, Belgium.
    Frelut, Marie-Laure
    ECOG, B-1000 Brussels, Belgium;Brindisi Hosp, Dept Paediat, I-72100 Brindisi, Italy.
    Erhardt, Eva
    ECOG, B-1000 Brussels, Belgium;Univ Pecs, Dept Paediat, H-7600 Pecs, Hungary.
    Forslund, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. ECOG, B-1000 Brussels, Belgium.
    Boyland, Ema
    ECOG, B-1000 Brussels, Belgium;Univ Liverpool, Appetite & Obes Res Grp, Dept Psychol Sci, Liverpool L69 7ZA, Merseyside, England.
    Weghuber, Daniel
    ECOG, B-1000 Brussels, Belgium;Paracelsus Med Univ, Dept Pediat, Obes Res Unit, A-5020 Salzburg, Austria.
    Thivel, David
    ECOG, B-1000 Brussels, Belgium;Clermont Auvergne Univ, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Auvergne Reg Ctr Human Nutr, F-63000 Clermont Ferrand, France.
    Could sport be part of pediatric obesity prevention and treatment?: Expert conclusions from the 28th European Childhood Obesity Group Congress2019In: Journal of Sport and Health Science, ISSN 2095-2546, E-ISSN 2213-2961, Vol. 8, no 4, p. 350-352Article in journal (Other academic)
  • Haglöf, F.
    et al.
    KTH Royal Inst Technol, Mat Sci & Engn, S-10044 Stockholm, Sweden;Sandvik Coromant R&D, S-12679 Stockholm, Sweden.
    Kaplan, B.
    Sandvik Coromant R&D, S-12679 Stockholm, Sweden.
    Norgren, Susanne
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. Sandvik Coromant R&D, S-12679 Stockholm, Sweden.
    Blomqvist, A.
    Sandvik Coromant R&D, S-12679 Stockholm, Sweden.
    Selleby, M.
    KTH Royal Inst Technol, Mat Sci & Engn, S-10044 Stockholm, Sweden.
    Experimental study of carbides in the Ti-Cr-C system2019In: Journal of Materials Science, ISSN 0022-2461, E-ISSN 1573-4803, Vol. 54, no 19, p. 12358-12370Article in journal (Refereed)
    Abstract [en]

    The Ti-Cr-C system has been studied by producing samples within the MC-M3C2-M7C3 (M=Ti, Cr) and MC-M3C2-graphite equilibria. The main purpose was to determine the solubility of Cr in MC; however, the solubility of Ti in M3C2 and M7C3 was also of interest, as well as the C content in MC. Heat treatments have been performed at 1673 and 1773 K for 300 h. Thereafter, the phase compositions have been measured with energy-dispersive X-ray spectroscopy (EDS) and wavelength-dispersive X-ray spectroscopy (WDS). X-ray diffraction (XRD), in combination with Rietveld refinement, has been used to determine the lattice parameter for MC. Density functional theory (DFT) calculations were performed to estimate the lattice parameter for MC as a function of composition, and the Rietveld refined lattice parameters for MC have then been recalculated to compositions in order to verify the EDS measurements. The results show that the EDS and XRD measurements give equal results. One conclusion is that, with the current conditions, 300 h is a sufficient heat treatment time in order to reach thermodynamic equilibrium. The other main conclusion is that the solubility of Cr in MC, in general, was overestimated by previous studies due to too short heat treatment times, but also that the solubility is very temperature dependent, especially for the MC-M3C2-graphite equilibrium. This clear temperature dependence was not taken into account in the existing thermodynamic description found in the literature.

  • Mustafa, Arshi
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Winberg: Behavioral Neuroendocrinology. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology.
    Thörnqvist, Per-Ove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Winberg: Behavioral Neuroendocrinology.
    Roman, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Winberg, Svante
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Winberg: Behavioral Neuroendocrinology.
    The aggressive spiegeldanio, carrying a mutation in the fgfr1a gene, has no advantage in dyadic fights with zebrafish of the AB strain2019In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 370, article id 111942Article in journal (Refereed)
    Abstract [en]

    Zebrafish which carries a mutation in the fibroblast growth factor receptor 1A (fgfr1a), also known as spiegeldanio (spd), has previously been reported to be bolder and more aggressive than wildtype (AB) zebrafish. However, in previous studies aggression has been quantified in mirror tests. In dyadic fights the behavior of the combatants is modified by the behavior of their opponent, and fighting a mirror has been reported to have different effects on brain gene expression and brain monoaminergic systems. In the present study aggression was quantified in fgfr1a mutants and AB zebrafish using a mirror test after which the fish were allowed to interact in pairs, either consisting of two fgfr1a mutants or one AB and one fgfr1a mutant fish. Following dyadic interaction aggressive behavior was again quantified in individual fish in a second mirror test after which the fish were sacrificed and brain tissue analyzed for monoamines and monoamine metabolites. The results confirm that fgfr1a mutants are more aggressive than AB zebrafish in mirror tests. However, fgfr1a mutant fish did not have any advantage in fights for social dominance, and agonistic behavior of fgfr1a mutants did not differ from that of AB fish during dyadic interactions. Moreover, as the AB fish, fgfr1a mutant fish losing dyadic interactions showed a typical loser effect and social subordination resulted in an activation of the brain serotonergic system in fgfr1a mutants as well as in AB fish. Overall the effects of dyadic interaction were similar in fgfr1a mutant fish and zebrafish of the AB strain.

  • Barkelind, Malin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    De nordiska biblioteken: En undersökning av Nordisk kulturkontakts och Nordens hus biblioteks identitetsskapande2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The aim of this thesis is to examine the construction of Nordic and organizational identities performed by the libraries of two Nordic cultural institutions: the Nordic Culture Point in Helsinki, Finland, and the Nordic House in Reykjavik, Iceland. To do this, three main methods were used: (a) Fairclough’s critical discourse analysis was employed to interpret the institutions’ self-representations, (b) the topics of debates and talks organized by the institutions were analysed and (c) interviews were performed with librarians currently working at these libraries.

    The results show that the institutions are (re)presented as two separate units rather than two parts of the same organization. The Nordic Culture Point is more explicitly connected to the Nordic Council of Ministers while the Nordic House presents itself as an iconic building in a marketing manner.

    The institutions are affected by politically defined themes and values, which permeate their events. The most common themes for talks and debates were literature, environmental issues or sustainable development, and politics. Even though there is a clear influence from political strategy documents, many topics with little or no connection to these documents were found. In addition, the literature selection processes at these libraries do not seem to be largely affected by politically defined priorities, based on the librarians’ views.

    According to the librarians who were interviewed, the aim of the Nordic libraries is to offer literature in the Nordic languages that would otherwise be difficult to access, gather this literature in one location, and promote interest in the Nordic region. While they agree that the main point of reference for the Nordic libraries is public libraries, the librarians differ on the role digital technology should play in the library.

    This is a two years master’s thesis in Library and Information Science.

  • Koch, Benjamin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Stapel, Janny
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    The role of head and hand movements for infants' predictions of others' actions2019In: Psychological Research, ISSN 0340-0727, E-ISSN 1430-2772, Vol. 83, no 6, p. 1269-1280Article in journal (Refereed)
    Abstract [en]

    In everyday life, both the head and the hand movements of another person reveal the other's action target. However, studies on the development of action prediction have primarily included displays in which only hand and no head movements were visible. Given that infants acquire in their first year both the ability to follow other's gaze and the ability to predict other's reaching actions, the question is whether they rely mostly on the hand or the head when predicting other's manual actions. The current study aimed to provide an answer to this question using a screen-based eye tracking setup. Thirteen-month-old infants observed a model transporting plastic rings from one side of the screen to the other side and place them on a pole. In randomized trials the model's head was either visible or occluded. The dependent variable was gaze-arrival time, which indicated whether participants predicted the model's action targets. Gaze-arrival times were not found to be different when the head was visible or rendered invisible. Furthermore, target looks that occurred after looks at the hand were found to be predictive, whereas target looks that occurred after looks at the head were reactive. In sum, the study shows that 13-month-olds are capable of predicting an individual's action target based on the observed hand movements but not the head movements. The data suggest that earlier findings on infants' action prediction in screen-based tasks in which often only the hands were visible may well generalize to real-life settings in which infants have visual access to the actor's head.

  • Brekkan, Ari
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Pharmetheus, Uppsala, Sweden.
    Lopez-Lazaro, Luis
    Dr Reddys Labs, Basel, Switzerland.
    Plan, Elodie L.
    Pharmetheus, Uppsala, Sweden.
    Nyberg, Joakim
    Pharmetheus, Uppsala, Sweden.
    Kankanwadi, Suresh
    Dr Reddys Labs, Basel, Switzerland.
    Karlsson, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Pharmetheus, Uppsala, Sweden.
    Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies2019In: AAPS Journal, ISSN 1550-7416, E-ISSN 1550-7416, Vol. 21, no 5, article id 85Article in journal (Refereed)
    Abstract [en]

    In this work, a previously developed pegfilgrastim (PG) population pharmacokinetic-pharmacodynamic (PKPD) model was used to evaluate potential factors of importance in the assessment of PG PK and PD similarity. Absolute neutrophil count (ANC) was the modelled PD variable. A two-way cross-over study was simulated where a reference PG and a potentially biosimilar test product were administered to healthy volunteers. Differences in delivered dose amounts or potency between the products were simulated. A different baseline absolute neutrophil count (ANC) was also considered. Additionally, the power to conclude PK or PD similarity based on areas under the PG concentration-time curve (AUC) and ANC-time curve (AUEC) were calculated. Delivered dose differences between the products led to a greater than dose proportional differences in AUC but not in AUEC, respectively. A 10% dose difference from a 6mg dose resulted in 51% and 7% differences in AUC and AUEC, respectively. These differences were more pronounced with low baseline ANC. Potency differences up to 50% were not associated with large differences in either AUCs or AUECs. The power to conclude PK similarity was affected by the simulated dose difference; with a 4% dose difference from 6mg the power was approximately 29% with 250 subjects. The power to conclude PD similarity was high for all delivered dose differences and sample sizes.

  • Gottipati, Gopichand
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Berges, Alienor C.
    GlaxoSmithKline, London, England;AstraZeneca, IMED Biotech Unit, Early Clin Dev, Quantitat Clin Pharmacol, Cambridge, England.
    Yang, Shuying
    GlaxoSmithKline, London, England.
    Chen, Chao
    GlaxoSmithKline, London, England.
    Karlsson, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Plan, Elodie L.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Item Response Model Adaptation for Analyzing Data from Different Versions of Parkinson's Disease Rating Scales2019In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 36, no 9, article id 135Article in journal (Refereed)
    Abstract [en]

    Purpose: The aim of this work was to allow combination of information from recent and historical trials in Parkinson's Disease (PD) by developing bridging methodology between two versions of the clinical endpoint.

    Methods: A previously developed Item Response Model (IRM), that described longitudinal changes in Movement Disorder Society (MDS) sponsored revision of Unified Parkinson's Disease Rating Scale (UPDRS) [MDS-UPDRS] data from the De Novo PD cohort in Parkinson's Progression Markers Initiative, was first adapted to describe baseline UPDRS data from two clinical trials, one in subjects with early PD and another in subjects with advanced PD. Assuming similar IRM structure, items of the UPDRS version were mapped to those in the MDS-UPDRS version. Subsequently, the longitudinal changes in the placebo arm of the advanced PD study were characterized.

    Results: The parameters reflecting differences in the shared items between endpoints were successfully estimated, and the model diagnostics indicated that mapping was better for early PD subjects (closer to De Novo cohort) than for advanced PD subjects. Disease progression for placebo in advanced PD patients was relatively shallow.

    Conclusion: An IRM able to handle two variants of clinical PD endpoints was developed; it can improve the utilization of data from diverse sources and diverse disease populations.

  • Psimopoulos, Emmanouil
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences. Dalarna Univ, Energy Technol, Borlange, Sweden.
    Bee, Elena
    Univ Trento, Dept Civil Environm & Mech Engn, Trento, Italy.
    Widén, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Bales, Chris
    Dalarna Univ, Energy Technol, Borlange, Sweden.
    Techno-economic analysis of control algorithms for an exhaust air heat pump system for detached houses coupled to a photovoltaic system2019In: Applied Energy, ISSN 0306-2619, E-ISSN 1872-9118, Vol. 249, p. 355-367Article in journal (Refereed)
    Abstract [en]

    Operational control strategies for the heating system and "smart" utilization of energy storage were developed and analyzed in a simulation based case study of a single-family house with exhaust air heat pump and photovoltaic system. Rule based control algorithms that can easily be implemented into modern heat pump controllers were developed with the aim to minimize final energy and maximize self-consumption by the use of the thermal storage of the building, the hot water tank and electrical storage. Short-term weather and electricity price forecasts are used in some of the algorithms. Heat supply from an exhaust air heat pump is limited by the ventilation flow rate fixed by building codes, and compact systems employ an electric heater as backup for both space heating and hot water. This heater plays an important role in the energy balance of the system. A typical system designed for new detached houses in Sweden was chosen for the study. This system, together with an independent photovoltaic system, was used as a base case and all results are compared to those for this base case system. TRNSYS 17 was used to model the building and system as well as the control algorithms, and special care was taken to model the use of the backup electric heater as this impacts significantly on final energy use. Results show that the developed algorithms can reduce final energy by 5-31% and the annual net cost for the end user by 3-26%, with the larger values being for systems with a battery storage. Moreover, the annual use of the backup electric heater can be decreased by 13-30% using the carefully designed algorithms.

  • Howe, Christoph
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Moparthi, Vamsi
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Ho, Felix M.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Persson, Karina
    Department of Chemistry, Umeå University, Umeå, Sweden.
    Stensjö, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    The Dps4 from Nostoc punctiforme ATCC 29133 is a member of His-type FOC containing Dps protein class that can be broadly found among cyanobacteria2019In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 8, article id e0218300Article in journal (Refereed)
    Abstract [en]

    Dps proteins (DNA-binding proteins from starved cells) have been found to detoxify H2O2. At their catalytic centers, the ferroxidase center (FOC), Dps proteins utilize Fe2+ to reduce H2O2 and therefore play an essential role in the protection against oxidative stress and maintaining iron homeostasis. Whereas most bacteria accommodate one or two Dps, there are five different Dps proteins in Nostoc punctiforme, a phototrophic and filamentous cyanobacterium. This uncommonly high number of Dps proteins implies a sophisticated machinery for maintaining complex iron homeostasis and for protection against oxidative stress. Functional analyses and structural information on cyanobacterial Dps proteins are rare, but essential for understanding the function of each of the NpDps proteins. In this study, we present the crystal structure of NpDps4 in its metal-free, iron- and zinc-bound forms. The FOC coordinates either two iron atoms or one zinc atom. Spectroscopic analyses revealed that NpDps4 could oxidize Fe2+ utilizing O2, but no evidence for its use of the oxidant H2O2 could be found. We identified Zn2+ to be an effective inhibitor of the O2-mediated Fe2+ oxidation in NpDps4. NpDps4 exhibits a FOC that is very different from canonical Dps, but structurally similar to the atypical one from DpsA of Thermosynechococcus elongatus. Sequence comparisons among Dps protein homologs to NpDps4 within the cyanobacterial phylum led us to classify a novel FOC class: the His-type FOC. The features of this special FOC have not been identified in Dps proteins from other bacterial phyla and it might be unique to cyanobacterial Dps proteins.

  • Mathioudaki, Argyri
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Nordin, Jessika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Karlsson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Murén, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Hultin-Rosenberg, Lina
    Bianchi, Matteo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Eriksson, Daniel
    Pettersson, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Neumann, Leonie
    Hartmann, Annalena
    Farias, Fabiana H. G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dahlqvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    ImmunoArray Development Consortium, ImmunoArray Development Consortium
    Welander, Jenny
    Klinberg, Eva
    Forsblad-d'Elia, Helena
    Pielberg, Gerli
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kastbom, Alf
    Linköping University.
    Cedergren, Jan
    Linköping University.
    Eriksson, Per
    Linköping University.
    Lindblad-Toh, Kerstin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Meadows, Jennifer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    The sex-stratified genetic architecture of ankylosing spondylitisManuscript (preprint) (Other academic)
    Abstract [en]

    Sexual dimorphism is an emerging feature of ankylosing spondylitis (AS), a chronic rheumatic condition affecting up

    to three times more men than women. Using 691 individuals from a Swedish case-control cohort, we revealed that

    sex biases are also a hallmark of AS genetic predisposition, and that this multifactorial disease is in part driven by

    both rare and common variants. We identified SNPs via the targeted re-sequencing of 7 270 coding and non-coding

    loci, and assessed novel patterns of association with both single marker and aggregate loci SKAT tests. The male

    specific RUNX3 locus (including rs7414934, OR=2.58, p=1.7x10-5) and female specific MICB SKAT locus (27

    variants, p=1.2x10-6; rs3828903, OR=4.62, p=6.2x10-13) exceeded discovery thresholds. Multiple risk variants from

    each locus were shown to be functionally active in immune (Jurkat), skin (HaCat) and bone (SaOS-2) cell lines.

    Differential patterns of genetic predisposition may point to alternative disease mechanisms in male and female

    patients. Genetic and functional analyses demonstrated that risk alleles should not be considered in isolation and that

    associated variants would likely affect gene regulation across multiple tissues. This work illustrates the need to

    consider the contribution of sex to the genetics of AS and the duality that individual loci may play in the key clinical outcomes of disease.

  • Landegren, Nils
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden.
    Rosen, Lindsey B.
    NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
    Freyhult, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab. Natl Bioinformat Infrastruct, Dept Med Sci, Uppsala, Sweden.
    Eriksson, Daniel
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.
    Fall, Tove
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Smith, Gustav
    Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, Lund, Sweden;MIT, Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02139 USA;Lund Univ, Ctr Diabet, Wallenberg Ctr Mol Med, Lund, Sweden.
    Ferre, Elise M. N.
    NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
    Brodin, Petter
    Lund Univ, Skane Univ Hosp, Dept Cardiol, Clin Sci, Lund, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden;Karolinska Univ Hosp, Dept Newborn Med, Stockholm, Sweden.
    Sharon, Donald
    Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA.
    Snyder, Michael
    Lund Univ, Ctr Diabet, Wallenberg Ctr Mol Med, Lund, Sweden;Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA.
    Lionakis, Michail
    NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
    Anderson, Mark
    Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA.
    Kampe, Olle
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden;Univ Bergen, KG Jebsen Ctr Autoimmune Dis, Bergen, Norway.
    Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'2019In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e43578Article in journal (Other academic)
    Abstract [en]

    The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

  • Linderoth, Rebecca
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Alsterlund, Ebba
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Millennials i den digitala sektorn: En fallstudie om hur du motiverar och behåller generationen på arbetsplatsen2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den tekniska utvecklingen har bidragit till att den digitala sektorn har blivit näringslivets största tillväxtområde. Statistiska undersökningar visar att den svenska arbetsmarknaden år 2022 kommer sakna 70 000 individer som besitter rätt IT-kompetens. Inom en snar framtid kommer de tidigare generationerna lämna arbetsmarknaden och Millennials kommer utgöra en allt större del. Motivation är ett viktigt begrepp inom företagsvärlden då det är en förutsättning för att individer ska vilja utföra en arbetsuppgift. Ett sätt för företag att skapa och upprätthålla motivation hos sina medarbetare är välanpassade belöningssystem. Syftet med denna uppsats utgörs av två delar. Den första delen syftar till att få en djupare förståelse för hur Millennials i den digitala sektorn upplever att de motiveras av olika motivationsfaktorer. Den andra delen syftar till att med hjälp av resultat och analys av syftets första del ge vägledning i vad svenska företag i den digitala sektorn bör ta hänsyn till vid utformning av belöningssystem för att motivera och behålla Millennials på arbetsplatsen. För att besvara syftet har semistrukturerade intervjuer genomförts med Millennials från ett svenskt IT-företag. Resultatet visar att de betydande motivationsfaktorerna för Millennials i den digitala sektorn är: ansvar, balans mellan arbete och fritid, flexibilitet, personlig utveckling, gemenskap och kultur, meningsfulla arbetsuppgifter, samt snabb och kontinuerlig feedback. Samtidigt visar studien att lön inte upplevs vara en motivationsfaktor, trots detta betraktas hög lön som en självklarhet i ITbranschen. Belöningssystem bör därmed utformas med hänsyn till både finansiella och ickefinansiella belöningar med fokus på dessa motivationsfaktorer. 

  • Schiess, Michaela
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Teir, Johanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ett internationellt universitet: Hur svenska universitet attraherar avgiftsskyldiga studenter2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Allt fler personer väljer idag att studera vidare på universitet vilket har lett till att utbildningsnivån internationellt sett är högre än någonsin. Den globala konkurrensen som framkommit mellan universiteten har gjort det viktigt att marknadsföra sig för att konkurrera om studenter på rekryteringsmarknaden. Med hjälp av teorier inom kommunikation, PR och varumärke har kvalitativa intervjuer med personer som var och en arbetar med internationell studentrekrytering på svenska universitet genomförts. Syftet med studien är att få en tydligare bild av hur svenska universitet arbetar med att attrahera avgiftsskyldiga studenter till sina lärosäten. Undersökningen visar på att svenska universitet använder sig av liknande kommunikationsinsatser för att attrahera avgiftsskyldiga studenter. Studiens resultat tyder på att det i slutändan handlar om hur de svenska universiteten bygger upp sitt varumärke genom olika konstant pågående insatser för att differentiera sig i förhållande till sina konkurrenter vilket bidrar till universitetens attraktionskraft hos presumtiva studenter.

  • Wener, Sofia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ragnhäll, Rebecka
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Havredryckens gröna värde: En studie om samskapande av värde mellan Oatly och deras konsumenter2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Många konsumenter strävar idag efter en mer hållbar konsumtion och företag vill därför förmedla sina gröna arbetssätt för att attrahera kunder. Frågan är om företags hållbarhetsarbete och kommunikation av detta verkligen får människor att konsumera deras varor och tjänster, eller om konsumenter samtidigt behöver inneha viss kunskap för att värdesätta företagets hållbarhetsarbete. Studien syftar till att undersöka hur kunskap om hållbarhet leder till samskapande av värde mellan producent och konsument genom tre värdeskapande aktiviteter. Studien har särskilt granskat det svenska företaget Oatly och dess konsumenter. Det empiriska underlaget har samlats in genom en webbenkät som besvarades av 994 respondenter. Resultatet visar att kunskap om hållbarhet hos respondenterna har en positiv signifikant effekt på samskapande av värde med Oatly. Värdesamskapande sker främst genom en sammanslagning av de värdeskapande aktiviteterna kunskapsförnyelse, relationsutveckling och kommunikation. Studien bidrar till en bättre förståelse kring hur konsumenter och producenter samskapar värde genom gemensamma värderingar om hållbarhet.

  • Liljebäck, Hanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Espes, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Transplantation and regenerative medicine.
    Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement2019In: Cell Medicine, ISSN 2155-1790, E-ISSN 2155-1790, Vol. 11, article id 2155179019857662Article in journal (Other academic)
    Abstract [en]

    The liver is currently the site of choice for clinical islet transplantation, even though many alternative implantation sites have lately been proposed as more ideal for graft survival. The suggested sites, for example intramuscular space, omentum, bone marrow, and spleen, are sometimes difficult to compare due to differences in animal model, islet isolation procedure, and islet quality. In addition, the variation in transplanted islet mass is vast. The aim of this commentary is to review alternative implantation sites tested experimentally as well as in clinical islet transplantation. Although many sites have been investigated, none have convincingly proved better suited for clinical islet transplantation than intraportal injection to the liver, regardless of whether it is autologous or allogeneic transplantation. However, in order to fully evaluate upcoming bioengineering techniques, such as scaffolds containing insulin-producing cells derived from stem cells, the need of an alternative site has arisen to enable cellular monitoring, which currently cannot be achieved within the liver.

  • El Gohary, Fouad
    Microgrid Economics: Incentivizing Self-Consumption of Solar Electricity in a DC Microgrid2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Roxner, Evelina
    et al.
    International Iberian Nanotechnology Laboratory.
    Olsmats Baumeister, Ronja
    International Iberian Nanotechnology Laboratory.
    Processing of Sub-micrometer Features for Rear Contact Passivation Layer of Ultrathin Film Solar Cells Using Optical Lithography2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Thin film copper, indium, gallium, selenide (CIGS) solar cells are promising in the field of photovoltaic technology. To reduce material and fabrication cost, as well as increasing electrical properties of the cell, research is ongoing towards ultra-thin film solar cells (absorption layer thickness less than 500 nm). Ultra-thin CIGS solar cells has shown a decrease in interface recombination and improved optical properties when adding a rear contact passivation layer of aluminium oxide.

    In this work, the process of creating sub-micrometer features of a passivation layer using conventional optical lithography is investigated. To specify, the objective was to optimize the development conditions in the optical lithography process when fabricating equidistant line contacts in aluminium oxide with 800 nm feature size. It was found that line contacts with smaller feature sizes require longer development time, than line contacts with larger feature sizes. The experiments conducted showed that the pre-set development and exposure conditions used by the NOA group are not optimized for 800 nm or smaller line contacts.

    Further, for the optical lithography process, silicon substrates are not comparable with substrates of soda lime glass coated with molybdenum. Slight underdevelopment of a sample, showed line contacts smaller than the resolution of the laser used in the exposure – suggesting an alternative method of processing small line contacts with optical lithography.

  • Bjervig, Joel
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Slagbrand, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Thermal Imaging Platform for Drones: Cost-effective localization of forest fires2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    A device for identifying forest fires in an early stage has been developed during the course of this project. Attached to a drone, this prototype will provide a live-stream to a web server displaying a blended frame, made of a thermographic image showing thermal radiation and a regular photography with the visible light. The platform consists of a small single-boarded computer, a thermal camera sensor and a regular camera module. All powered by a power bank and fitted into a custom made 3D printed plastic case. At startup the computer automatically executes scripts written in Python, initializing its sensor components and processes the captured images which finally gets transmitted to a live-stream via a web server connection. Everything described above worked well, but originally the intent was for the web interface to provide a map with the current location coordinates of the drone. Since a module for mobile communication with support for GPS was not acquired, any implementation of such kind was impossible. However, several drone models already possess the feature to obtain such coordinates.

  • Grüning, Björn A.
    et al.
    Univ Freiburg, Dept Comp Sci, Bioinformat Grp, Georges Koehler Allee 106, D-79110 Freiburg, Germany;Univ Freiburg, Ctr Biol Syst Anal ZBSA, Habsburgerstr 49, D-79104 Freiburg, Germany.
    Lampa, Samuel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Stockholm Univ, Natl Bioinformat Infrastruct Sweden, Sci Life Lab, Dept Biochem & Biophys, Svante Arrhenius Vag 16C, S-10691 Solna, Sweden.
    Vaudel, Marc
    Univ Bergen, Dept Clin Sci, KG Jebsen Ctr Diabet Res, Postboks 7804, N-5020 Bergen, Norway;Haukeland Hosp, Ctr Med Genet & Mol Med, Postboks 7804, N-5020 Bergen, Norway.
    Blankenberg, Daniel
    Cleveland Clin, Lerner Res Inst, Genom Med Inst, 9500 Euclid Ave NE50, Cleveland, OH 44106 USA.
    Software engineering for scientific big data analysis2019In: GigaScience, ISSN 2047-217X, E-ISSN 2047-217X, Vol. 8, no 5, article id giz054Article, review/survey (Refereed)
    Abstract [en]

    The increasing complexity of data and analysis methods has created an environment where scientists, who may not have formal training, are finding themselves playing the impromptu role of software engineer. While several resources are available for introducing scientists to the basics of programming, researchers have been left with little guidance on approaches needed to advance to the next level for the development of robust, large-scale data analysis tools that are amenable to integration into workflow management systems, tools, and frameworks. The integration into such workflow systems necessitates additional requirements on computational tools, such as adherence to standard conventions for robustness, data input, output, logging, and flow control. Here we provide a set of 10 guidelines to steer the creation of command-line computational tools that are usable, reliable, extensible, and in line with standards of modern coding practices.

  • Rosén, Elin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Abdelki, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Abdulla, Beyar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Bugurcu, Alan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    El Nabelsi, Mahmoud
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Oxygenation conducted in low temperature clean water2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Aeration tests were conducted under non-standard conditions with clean tap water in various temperatures below 20 °C, with the aim of studying changes that may occur. An initial deoxygenation of 0.8 litre water was performed with sodium sulfite and a cobalt catalyst pre-dissolved in water, in order to bind already present dissolved oxygen. The resulting dissolved oxygen concentration after 20 minutes did not decrease below 2 mg/L, despite increasing the sodium sulfite concentrations. Thereafter, a reoxygenation with the same time interval was conducted by using an aeration system, which resulted in an increase of saturated oxygen concentration with lower temperatures. pH-measurements were carried out during the whole experiment in order to follow the conversion of sulfite to sulfate. The pH-data obtained confirmed that sulfite had been converted to sulfate, although, a few deviations could be observed for most of the experiments. The conductivity was also measured to ensure that the sulfite had been properly dissolved when added to the water tank. In general, the conductivity never deviated and held a constant trend throughout the tests. The collected data could not be made of use in order to properly determine how the aeration, for temperatures below 20 °C, could be evaluated. Further tests have to be performed in order for a definite conclusion to be drawn.

  • Nygren, Thomas
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Brounéus, Fredrik
    Vetenskap & Allmänhet.
    Svensson, Göran
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Diversity and credibility in young people’s news feeds: A foundation for teaching and learning citizenship in a digital era2019In: Journal of Social Science Education, ISSN 1611-9665, E-ISSN 1618-5293, Vol. 18, no 2, p. 87-109Article in journal (Refereed)
    Abstract [en]

    Key points: – Citizen science approach to map young people’s digital news feeds.− Students predominately read hard news.− Digital news comes primarily from established news media sites deemed credible by students.− On social media, students mostly share news they find credible.− Students' authentic news feeds as potentials and challenges in education and democracy.

    Purpose: The credibility of digital news is presently a topic of debate, and curricula underline the importance of media literacy. However, the content and credibility of young people’s news feeds have not been investigated in detail in any large-scale studies. Here we explore the nature of news featured in Swedish upper secondary school students’ news feeds, how news is shared, and how credible the news is according to the students.Approach: Using citizen science and a mixed methods approach we review 2617 news from authentic news feeds.Findings: The students’ news feeds primarily contain hard news from established news media. News is predominately found on news domains, not through social media. Soft news is less common and is perceived as less credible. Boys find more sports while girls identify more entertainment and lifestyle news. The news feeds also contain some highly biased political information.Research limitations: The study was carried out in Sweden, and further international research on authentic news feeds is needed to view results in relation to society and educational practices.Research and practical implications: In education, students’ news feeds can be used to scrutinize credibility and help students navigate towards credible news domains to support democratic engagement.

  • Linander, Ida
    et al.
    Umea Univ, Unit Epidemiol & Global Hlth, Dept Publ Hlth & Clin Med, Umea, Sweden;Umea Univ, Umea Ctr Gender Studies, Umea, Sweden.
    Goicolea, Isabel
    Umea Univ, Unit Epidemiol & Global Hlth, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Alm, Erika
    Gothenburg Univ, Dept Cultural Sci, Gothenburg, Sweden.
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    Harryson, Lisa
    Umea Univ, Dept Social Work, Umea, Sweden.
    (Un)safe spaces, affective labour and perceived health among people with trans experiences living in Sweden2019In: Culture, Health and Sexuality, ISSN 1369-1058, E-ISSN 1464-5351, Vol. 21, no 8, p. 914-928Article in journal (Refereed)
    Abstract [en]

    Lack of safe space has been connected to ill health among people with trans experiences. This study analyses trans people's experiences of being in public, semi-public and community spaces using the analytical concept of safety/unsafety in relation to perceived health. The analytic framework draws on the concepts of cisgenderism, orientation, lines and comfort. The material analysed consisted of 18 individual interviews with people with trans experiences, which were analysed using constructivist thematic analysis. The analysis resulted in the identification of three themes: straightening devices creating limited living space, orienting oneself in (cis)gendered spaces and creating safer (?) community spaces for healing. Experiences of unsafety ranged from incidents and fear of different kinds of violence in public and semi-public spaces to the lack of a transpolitically informed agenda in, for example, feminist spaces. Safer spaces helped participants to feel a sense of belonging, to share their experiences and to heal. Experiences of unsafety and discomfort are important as they will help us to understand the health situations of people with trans experiences. It is important to facilitate the creation of safer spaces to improve the health of members of this group.

  • Rietjens, Sebastiaan
    et al.
    Netherlands Def Acad, Breda, Netherlands.
    Ruffa, Chiara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research. Swedish Def Univ, Stockholm, Sweden.
    Understanding Coherence in UN Peacekeeping: A Conceptual Framework2019In: International Peacekeeping, ISSN 1353-3312, E-ISSN 1743-906X, Vol. 26, no 4, p. 383-407Article in journal (Refereed)
    Abstract [en]

    Coherence is a core objective in most multinational interventions and seems of particular relevance to UN peacekeeping missions with their increasing complexity and multidimensionality. Yet, coherence has rarely been studied empirically. We borrow the concept of fit' from organizational theory and use it to develop a conceptual framework to study coherence in peacekeeping operations. Fit is the degree of match between what is required by the mandate, on the one hand, and an institutional set-up and the implemented practices, on the other. We identify three relevant dimensions of fit to study coherence: strategic and organizational, cultural and human and operational fit. Our empirical material focuses on the UN mission in Mali (MINUSMA) and in particular on the interplay between the intelligence components and the rest of the mission. We draw upon a large empirical dataset containing over 120 semi-structured interviews, field observations and participation in pre-deployment exercises and evaluation sessions. Our empirical analysis suggests that low level of fit across several dimensions leads to inertial and widespread frictions in the practice of peacekeeping and could potentially undermine peacekeeping effectiveness. Building on existing scholarship on micro-level approaches to peacekeeping, we hope to further the debate on organizational dynamics within peace operations.

  • Turkki, Riku
    et al.
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland;Karolinska Inst, Sci Life Lab SciLifeLab, Solna, Sweden.
    Byckhov, Dmitrii
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
    Lundin, Mikael
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
    Isola, Jorma
    Univ Tampere, Dept Canc Biol, BioMediTech, Tampere, Finland.
    Nordling, Stig
    Univ Helsinki, Dept Pathol, Medicum, Helsinki, Finland.
    Kovanen, Panu E.
    Helsinki Univ Hosp, HUSLAB, Ctr Canc, Helsinki, Finland;Helsinki Univ Hosp, Medicum, Ctr Canc, Helsinki, Finland;Univ Helsinki, Helsinki, Finland.
    Verrill, Clare
    Univ Oxford, Nuffield Dept Surg Sci, Oxford, England;NIHR Oxford Biomed Res Ctr, Oxford, England.
    von Smitten, Karl
    Eira Hosp, Helsinki, Finland.
    Joensuu, Heikki
    Univ Helsinki, Helsinki, Finland;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.
    Lundin, Johan
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Linder, Nina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH). Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
    Breast cancer outcome prediction with tumour tissue images and machine learning2019In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 177, no 1, p. 41-52Article in journal (Refereed)
    Abstract [en]

    Purpose: Recent advances in machine learning have enabled better understanding of large and complex visual data. Here, we aim to investigate patient outcome prediction with a machine learning method using only an image of tumour sample as an input.

    Methods: Utilising tissue microarray (TMA) samples obtained from the primary tumour of patients (N=1299) within a nationwide breast cancer series with long-term-follow-up, we train and validate a machine learning method for patient outcome prediction. The prediction is performed by classifying samples into low or high digital risk score (DRS) groups. The outcome classifier is trained using sample images of 868 patients and evaluated and compared with human expert classification in a test set of 431 patients.

    Results: In univariate survival analysis, the DRS classification resulted in a hazard ratio of 2.10 (95% CI 1.33-3.32, p=0.001) for breast cancer-specific survival. The DRS classification remained as an independent predictor of breast cancer-specific survival in a multivariate Cox model with a hazard ratio of 2.04 (95% CI 1.20-3.44, p=0.007). The accuracy (C-index) of the DRS grouping was 0.60 (95% CI 0.55-0.65), as compared to 0.58 (95% CI 0.53-0.63) for human expert predictions based on the same TMA samples.

    Conclusions: Our findings demonstrate the feasibility of learning prognostic signals in tumour tissue images without domain knowledge. Although further validation is needed, our study suggests that machine learning algorithms can extract prognostically relevant information from tumour histology complementing the currently used prognostic factors in breast cancer.

  • Ablikim, M.
    et al.
    Ikegami Andersson, Walter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Evidence for the decays of Lambda(+)(C) -> Sigma(+) eta and Sigma(+) eta '2019In: Chinese Physics C, High Energy Physics & Nuclear Physics, ISSN 1674-1137, E-ISSN 0899-9996, Vol. 43, no 8, article id 083002Article in journal (Refereed)
    Abstract [en]

    We study the hadronic decays of Lambda(+)(C) to the final states Sigma(+) eta and Sigma(+) eta', using an e(+) e(-) annihilation data sample of 567 pb(-1) taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCII collider. We find evidence for the decays Lambda(+)(C) -> Sigma(+) eta and Sigma(+) eta' with statistical significance of and, respectively. Normalizing to the reference decays Lambda(+)(C) -> Sigma(+) pi(0) and Sigma(+) omega, we obtain the ratios of the branching fractions B(Lambda(+)(C) -> Sigma(+) eta)/B(Lambda(+)(C) -> Sigma(+) pi(0)) and B(Lambda(+)(C) -> Sigma(+) eta')/B(Lambda(+)(C) -> Sigma(+) omega) to be 0.35 +/- 0.16 +/- 0.02 and 0.86 +/- 0.34 +/- 0.04, respectively. The upper limits at the 90% confidence level are set to be B(Lambda(+)(C) -> Sigma(+) eta)/B(Lambda(+)(C) -> Sigma(+) pi(0)) < 0.58 and B(Lambda(+)(C) -> Sigma(+) eta')/B(Lambda(+)(C) -> Sigma(+) omega) < 1.2. Using BESIII measurements of the branching fractions of the reference decays, we determine B(Lambda(+)(C) -> Sigma(+) eta) = (0.41 +/- 0.19 +/- 0.05)% (<0.68%) and B(Lambda(+)(C) -> Sigma(+) eta') = (1.34 +/- 0.53 +/- 0.19)% (<1.9%). Here, the first uncertainties are statistical and the second systematic. The obtained branching fraction of Lambda(+)(C) -> Sigma(+) eta is consistent with the previous measurement, and the branching fraction of Lambda(+)(C) -> Sigma(+) eta' is measured for the first time.

  • Ablikim, M.
    et al.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Biernat, Jacek
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Ikegami Andersson, Walter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Study of e(+)e(-) -> gamma omega J/psi and Observation of X(3872) -> omega J/psi2019In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 122, no 23, article id 232002Article in journal (Refereed)
    Abstract [en]

    We study the e(+)e(-) -> gamma omega J/psi process using 11.6 fb(-1) e(+)e(-) annihilation data taken at center-of-mass energies from root s = 4.008 GeV to 4.600 GeV with the BESIII detector at the BEPCII storage ring. The X(3872) resonance is observed for the first time in the omega J/psi system with a significance of more than 5 sigma. The relative decay ratio of X(3872) -> omega J/psi and pi(+)pi(-)J/psi is measured to be R = 1.6(-0.3)(+0.4) +/- 0.2, where the first uncertainty is statistical and the second systematic (the same hereafter). The root s-dependent cross section of e(+)e(-) -> gamma X(3872) is also measured and investigated, and it can be described by a single Breit- Wigner resonance, referred to as the Y(4200), with a mass of 4200.6(-13.3)(+7.9) +/- 3.0 MeV/c(2) and a width of 115(-26)(+38) +/- 12 MeV. In addition, to describe the omega J/psi mass distribution above 3.9 GeV/c(2), we need at least one additional Breit-Wigner resonance, labeled as X(3915), in the fit. The mass and width of the X(3915) are determined. The resonant parameters of the X(3915) agree with those of the Y(3940) in B -> K omega J/psi and of the X(3915) in gamma gamma -> omega J/psi observed by the Belle and BABAR experiments within errors.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zhang, Z.
    Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment2019In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 122, no 23, article id 231801Article in journal (Refereed)
    Abstract [en]

    Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H -> invisible decays where H is produced according to the standard model via vector boson fusion, Z(ll)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb(-1) of pp collisions at a center-of-mass energy of root s = 13 TeV at the LHC. In combination with the results at root s = 7 and 8 TeV, an exclusion limit on the H -> invisible branching ratio of 0.26(0.17(-0.05)(+0.07)) at 95% confidence level is observed (expected).

  • Ablikim, M.
    et al.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Biernat, Jacek
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Ikegami Andersson, Walter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Study of the decays D-s(+ )-> (KSK+)-K-0 and (KLK+)-K-02019In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 99, no 11, article id 112005Article in journal (Refereed)
    Abstract [en]

    Using an e(+)e(-) annihilation data sample corresponding to an integrated luminosity of 3.19 fb(-1) and collected at a center-of-mass energy root s = 4.178 GeV with the BESIII detector, we measure the absolute branching fractions B(D-s(+) -> (KSK+)-K-0) = (1.425 +/- 0.038(stat). +/- 0.031(syst).)% and B(D-s(+) -> (KLK+)-K-0) = (1.485 +/- 0.039(stat). +/- 0.046(syst).)%. The branching fraction of D-s(+) -> (KSK+)-K-0 is compatible with the world average and that of D-s(+) -> (KLK+)-K-0 is measured for the first time. We present the first measurement of the K-S(0)-K-L(0) asymmetry in the decays D-s(+) -> (KS,LK+)-K-0, and R((Ds+KS,LK+)-K-0) = B(D-s(+) -> (KSK+)-K-0)-B(D-s(+) -> (KLK+)-K-0)/B(D-s(+) -> (KSK+)-K-0)+B(D-s(+) -> (KLK+)-K-0) = (-2.1 +/- 1.9(stat). +/- 1.6(syst).)%. In addition, we measure the direct CP asymmetries A(CP) (D-s(+/-) -> (KSK +/-)-K-0). (0.6 +/- 2.8(stat). +/- 0.6(syst).)% and A(CP)(D-s(+/-) -> (KLK +/-)-K-0 ) = (-1.1 +/- 2.6(stat). +/- 0.6(syst))%.