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  • Törnros, Ludwig
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy.
    Nietzsche, epiphenomenalism and causal relationships between self-affirmation and the internal constitution of the drives2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Bourva, Ludovic
    et al.
    International Atomic Energy Agenca (IAEA).
    Jansson, PeterUppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    International Workshop on Numerical Modelling of NDA Instrumentation and Methods for Nuclear Safeguards: (NM-NDA-IMNS18)2018Conference proceedings (editor) (Other academic)
  • Public defence: 2018-12-13 09:15 80127, Uppsala
    Rakopoulos, Vasileios
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Isomeric yield ratio measurements with JYFLTRAP: In quest of the angular momentum of the primary fragments2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In this thesis, isomeric yield ratios of twenty nuclides produced in the fission of natU and 232Th by protons at 25-MeV and natU by high-energy neutrons were studied. The experiments were performed at the IGISOL-JYFLTRAP facility at the University of Jyväskylä. It is the first time that direct ion counting is used for the determination of the intensities of the states of interest, thus avoiding dependency on knowledge of nuclear decay schemes and properties. This was possible due to the superior resolution of a Penning trap which was utilized for this work. Two different techniques were employed, namely the sideband cooling technique and the phase-imaging ion-cyclotron-resonance technique. With the former, a mass resolving power of m/δm = 105 can be routinely achieved, while the latter, which was recently implemented at JYFLTRAP, offers an increase in the mass resolving power by a factor of ten. In addition, isomeric yield ratios were also determined by means of γ-ray spectroscopy.

    From a comparison of the same isomeric pair from two different reactions, a dependency on the fissioning system can be observed. This indicates an effect of the fission mode to the yield ratio. Moreover, the evolution of the odd-A isotopes of Cd and In in the mass range A = 119 - 127 exhibit two distinguishably different trends. The ratios for the isotopes of In decrease with increasing mass, while the ratios for the isotopes of Cd are almost constant until mass number A = 125, where an increase can be noticed.

    The origins of the angular momentum in the fission fragments is one of the long-standing questions regarding the fission process. Surprisingly, fission fragments have been observed to carry a considerable amount of angular momentum, even from fissioning systems with very low (or even zero) angular momentum. So far, the angular momentum can only be inferred from other fission observables, such as the isomeric yield ratios. In this work, a methodology was developed in order to deduce the root-mean-square angular momentum (Jrms) of the primary fragments by employing the nuclear reaction code TALYS.

    Lower values of Jrms for the more spherical nuclei, near the closed-shell neutron configuration at N = 82, and higher ones for fragments with odd proton number have been deduced, in agreement with other studies. Moreover, a correlation between the angular momentum of the primary fragments with the electric quadrupole moments of the products was observed for the isotopes of In. The data can be used to gain insight into scission configuration and as guide for models that propose mechanisms for the generation of the angular momentum. Furthermore, the observed correlation is an indication of the role that the repulsive Coulomb force, together with the shape of the nascent fragment, play in the generation of the fragments’ angular momentum.

    List of papers
    1. First isomeric yield ratio measurements by direct ion counting and implications for the angular momentum of the primary fission fragments
    Open this publication in new window or tab >>First isomeric yield ratio measurements by direct ion counting and implications for the angular momentum of the primary fission fragments
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    2018 (English)In: Physical Review C: Covering Nuclear Physics, ISSN 2469-9985, E-ISSN 2469-9993, Vol. 98, no 2, article id 024612Article in journal (Refereed) Published
    Abstract [en]

    We report the first experimental determination of independent isomeric yield ratios using direct ion counting with a Penning trap, which offered such a high resolution in mass that isomeric states could be separated. The measurements were performed at the Ion Guide Isotope Separator On-Line (IGISOL) facility at the University of Jyvaskyla. The isomer production ratios of Ge-81, Y-96,Y-97 Sn-128(,1)30, and Sb-129 in the 25-MeV proton-induced fission of U-na(t) and Th-232 were studied. Three isomeric pairs (Ge-81, Y-96, and Sb-129) were measured for the first time for the U-na(t)(p, f) reaction, while all the reported yield ratios for the Th-232(p, f) reaction were determined for the first time. The comparison of the experimentally determined isomeric yield ratios with data available in the literature shows a reasonable agreement, except for the case of Sn-130 for unspecified reasons. The obtained results were also compared with the GEF model, where good agreement can be noticed in most cases for both reactions. Serious discrepancies can only be observed for the cases of Y-96(,)97 for both reactions. Moreover, based on the isomeric yield ratios, the root-mean-square angular momenta (J(r)(ms)) of the fission fragments after scission were estimated using the TALYS code. The experimentally determined isomeric yield ratios, and consequently the deduced J(rms), for Sn-130 are significantly lower compared to Sn-128 for both fissioning systems. This can be attributed to the more spherical shape of the fragments that contribute to the formation of Sn-130, due to their proximity to the N = 82 shell closure. The values of J(rms) for Sb-129 are higher than Sn-128 for both reactions, despite the same neutron number of both nuclides (N = 78), indicating the odd-Z effect where fission fragments with odd-Z number tend to bear larger angular momentum than even-Z fragments. The isomer production ratio for the isotopes of Sn is more enhanced in the U-na(t)(p, f) reaction than in Th-232(p, f). The opposite is observed for Y-96 and Y-97. These discrepancies might be associated to different scission shapes of the fragments for the two fission reactions, indicating the impact that the different fission modes can have on the isomeric yield ratios.

    Place, publisher, year, edition, pages
    AMER PHYSICAL SOC, 2018
    National Category
    Subatomic Physics
    Identifiers
    urn:nbn:se:uu:diva-362692 (URN)10.1103/PhysRevC.98.024612 (DOI)000441464600003 ()
    Funder
    EU, FP7, Seventh Framework Programme, 605203Swedish Radiation Safety AuthoritySwedish Nuclear Fuel and Waste Management Company, SKBAcademy of Finland, 275389 284516 312544 295207
    Available from: 2018-10-18 Created: 2018-10-18 Last updated: 2018-11-06Bibliographically approved
    2. Isomeric fission yield ratios for odd-mass Cd & In isotopes using the Phase-Imaging Ion-Cyclotron-Resonance technique
    Open this publication in new window or tab >>Isomeric fission yield ratios for odd-mass Cd & In isotopes using the Phase-Imaging Ion-Cyclotron-Resonance technique
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Natural Sciences Subatomic Physics
    Research subject
    Physics with specialization in Nuclear Physics
    Identifiers
    urn:nbn:se:uu:diva-364949 (URN)
    Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2018-11-06
    3. Measurements of isomeric yield ratios of fission products from proton- induced fission on natU and 232Th via direct ion counting
    Open this publication in new window or tab >>Measurements of isomeric yield ratios of fission products from proton- induced fission on natU and 232Th via direct ion counting
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    2017 (English)In: ND 2016: INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY / [ed] Plompen, A.; Hambsch, FJ.; Schillebeeckx, P.; Mondelaers, W.; Heyse, J.; Kopecky, S.; Siegler, P.; Oberstedt, S., Les Ulis: EDP Sciences, 2017, Vol. 146, article id 04054Conference paper, Published paper (Refereed)
    Abstract [en]

    Independent isomeric yield ratios (IYR) of 81Ge, 96Y, 97Y, 97Nb, 128Sn and 130Sn have been determined in the 25 MeV proton-induced fission of natU and 232Th. The measurements were performed at the Ion Guide Isotope Separator On-Line (IGISOL) facility at the University of Jyväskylä. A direct ion counting measurement of the isomeric fission yield ratios was accomplished for the first time, registering the fission products in less than a second after their production. In addition, the IYRs of natU were measured by means of γ-spectroscopy in order to verify the consistency of the recently upgraded experimental setup. From the obtained results, indications of a dependence of the production rate on the fissioning system can be noticed. These data were compared with data available in the literature, whenever possible. Using the TALYS code and the experimentally obtained IYRs, we also deduced the average angular momentum of the fission fragments after scission.

    Place, publisher, year, edition, pages
    Les Ulis: EDP Sciences, 2017
    Series
    EPJ Web of Conferences, ISSN 2100-014X
    National Category
    Subatomic Physics
    Identifiers
    urn:nbn:se:uu:diva-319348 (URN)10.1051/epjconf/201714604054 (DOI)000426429500153 ()978-2-7598-9020-0 (ISBN)
    Conference
    ND 2016: International Conference on Nuclear Data for Science and Technology, 11-16 september 2016, Bruges, Belgium
    Funder
    Swedish Radiation Safety AuthoritySwedish Nuclear Fuel and Waste Management Company, SKB
    Available from: 2017-04-03 Created: 2017-04-03 Last updated: 2018-11-06Bibliographically approved
    4. Production of Sn and Sb isotopes in high-energy neutron induced fission of natU
    Open this publication in new window or tab >>Production of Sn and Sb isotopes in high-energy neutron induced fission of natU
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    2018 (English)In: European Physical Journal A, ISSN 1434-6001, E-ISSN 1434-601X, Vol. 54, article id 33Article in journal (Refereed) Published
    Abstract [en]

    The first systematic measurement of neutron-induced fission yields has been performed at the upgraded IGISOL-4 facility at the University of Jyvaskyla, Finland. The fission products from high-energy neutron-induced fission of U-nat were stopped in a gas cell filled with helium buffer gas, and were online separated with a dipole magnet. The isobars, with masses in the range A = 128-133, were transported to a tape-implantation station and identified using gamma-spectroscopy. We report here the relative cumulative isotopic yields of tin (Z = 50) and the relative independent isotopic yields of antimony (Z = 51). Isomeric yield ratios were also obtained for five nuclides. The yields of tin show a staggered behaviour around A = 131, not observed in the ENDF/B-VII. 1 evaluation. The yields of antimony also contradict the trend from the evaluation, but are in agreement with a calculation performed using the GEF model that shows the yield increasing with mass in the range A = 128-133.

    National Category
    Subatomic Physics
    Identifiers
    urn:nbn:se:uu:diva-328572 (URN)10.1140/epja/i2018-12462-1 (DOI)000428637900002 ()
    Funder
    EU, FP7, Seventh Framework Programme, 605203Swedish Radiation Safety AuthoritySwedish Nuclear Fuel and Waste Management Company, SKB
    Available from: 2017-08-26 Created: 2017-08-26 Last updated: 2018-11-06Bibliographically approved
    5. Extraction of angular momenta from isomeric yield ratios - assessment of TALYS as a fission fragment de-excitation code
    Open this publication in new window or tab >>Extraction of angular momenta from isomeric yield ratios - assessment of TALYS as a fission fragment de-excitation code
    (English)Manuscript (preprint) (Other academic)
    National Category
    Subatomic Physics
    Research subject
    Physics with specialization in Nuclear Physics
    Identifiers
    urn:nbn:se:uu:diva-364950 (URN)
    Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2018-11-06
  • Statham, Nataska
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Game Design.
    Scientific Rigour of Online Platforms for 3D Visualization of Heritage2019In: Virtual Archaeology Review, ISSN 1989-9947, p. 1-16Article in journal (Refereed)
    Abstract [en]

    3D visualisations –including 3D scans and 3D reconstructions–designed as part of larger archaeology, history or cultural heritage  projects  are  commonly  shared  with  the  public  through  online  platforms  that  were  not  necessarily  designed  to host  heritage  representations  and  often  fail  to  contextualize  them.  This  paper  seeks  to  evaluate  whether five online platforms commonly used today to share 3D visualisations of heritage (Google Arts & Culture, CyArk, 3DHOP, Sketchfab and  game  engines) offer  features that  facilitate  their scientific  rigour and community  participation,  based  on guidelines from International Council on Monuments and Sites(ICOMOS)and United Nations Educational, Scientific, and Cultural Organization(UNESCO). The author starts by summarizing recommendations from 32 international guidelines that are relevant to the 3D visualization of heritage, condensing them into nine key criteria: multi-disciplinary teams, objective-driven  methodology  and  tools,  careful  documentation, type  of  reconstruction  and  level  of  certainty,  authenticity, alternative  hypotheses,  multiple  historical  periods,  respectful  use  of  the  heritage, and  community  engagement. The author proceeds to review the platforms above comparing their features with these nine recommendations and concludes that, while there are currently available features that could help to elevate the scientific rigour of the 3D visualisations and their contextualization to  the  public, they are  not  mandatory  and  are  seldom  used.  The  paper  finishes  with  a recommendation for an information package to support3D visualisations of heritage on public online platforms.

  • Norén, Coco
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Romance Languages.
    Remarques sur la notion de point de vue2000In: Polyphonie-linguistique et littéraire, ISSN 1600-4647, no 2, p. 33-44Article in journal (Other academic)
  • Public defence: 2018-12-14 09:15 Skoogsalen, Uppsala
    Trbakovic, Amela
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
    Clinical and experimental studies of bone substitutes and dental implants in compromised bone sites2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: With an ageing population, an increase of more challenging implant treatments is expected. In this thesis, we evaluate the outcome of two faster implant protocols, in patients with compromised alveolar bone. We examine the bone integrating abilities of two new synthetic bone substitute materials and in another paper, we discuss the effects of nonsteroidal anti-inflammatory drugs (NSAID) on bone healing.

    Aim: In paper I we investigate implant survival and effect of reduced implant-tooth distance. In paper II we evaluate the long-term implant survival and function of immediately loaded implants. In paper III & IV, we analyse if added NSAID reduce postoperative pain and if it has a reduced effect on new bone formation in a rabbit sinus lift model. We also investigate if a ceramic compound (CPC, granules) and hydrogel (HABP.CaP) result in a similar or larger bone amount, in comparison with bovine bone mineral. In Paper V we assess new bone formation adjacent to a hollow CPC implant.

    Material & Methods: Paper I present a clinical and radiological follow-up, performed on subjects that previously received 3.0-3.3 mm diameter implants in the aesthetic area. In paper II, clinical and radiographic examinations were performed on subjects that had received six implants each with immediate loading in the maxilla 8-11-year ago. For paper III-IV, pain was assessed by clinical examination and scoring of facial expressions from photos. Histomorphometry and histology evaluations were performed. In paper V, a critical radius defect was created and either replaced by particulate autologous bone (AB) or a CPC implant. Qualitative and quantitative radiographic and histology evaluations were performed. 

    Results: In paper I, an implant survival of 97.2% up to 124 months was shown with a tooth-implant distance in many cases of  <1.5 mm. Discoloration and recession of the buccal gingiva was the most frequent patient concern. In paper II a cumulative implant survival rate was 81.9 % at the final follow-up. In paper III and IV it was shown that NSAID had no effect on pain relief or bone formation. No difference was shown between CPC and control, but both showed larger bone amount and BIC than HABP.CaP. In paper V new bone was seen in sites throughout the entire CPC implant.

    Conclusion: Satisfactory long-term dental implant results can be obtained without bone augmentation in most patients with atrophic alveolar bone, but there is still a minority in this group that may benefit of bone enhancement prior to implant treatment. To avoid the negative effects of autologous bone grafting, synthetic materials as the presented CPC, have shown promising results as a solution or alternative to existing bone substitutes in animal models.

    List of papers
    1. A clinical and radiological long-term follow-up study of narrow diameter implants in the aesthetic area
    Open this publication in new window or tab >>A clinical and radiological long-term follow-up study of narrow diameter implants in the aesthetic area
    2018 (English)In: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 20, no 4, p. 598-605Article in journal (Refereed) Published
    Abstract [en]

    Purpose

    To study long-term function of narrow diameter implants (NDI:s) and if reduced implant-tooth distance negatively impacts adjacent teeth.

    Materials and Methods

    A clinical and radiological follow-up of NDI:s replacing maxillary laterals and mandibular incisors was performed. Subjects that received 3.0-3.3 mm-diameter single implants from 3 units in Uppsala and Vasteras, Sweden, between 2002 and 2011 were offered to participate in this retrospective study.

    Results

    Twenty-seven patients (30 implants) underwent clinical and CBCT examination, mean follow-up time was 63.3 months. On average, the implant-tooth distance was 1.6 mm at the cervical region and 17 implants were placed 1 mm or less to the adjacent root. Additionally, 2 patients (3 implants) underwent clinical examination (I). Twenty-seven patients (36 implants) declined the examination but agreed to an interview (II). At the time of the follow-up, all implants had good function, and implant survival of group I and II together was 97.2%. In both groups, the 2 main patient concerns were discoloration and regression of the buccal gingiva.

    Conclusion

    Survival of implants is in accordance to standard diameter studies and although most implants were placed very close to the adjacent teeth, no pathologies could be linked to this except aesthetic concerns.

    Place, publisher, year, edition, pages
    WILEY, 2018
    Keywords
    cbct imaging, implant survival, long-term survival, narrow implants
    National Category
    Dentistry
    Identifiers
    urn:nbn:se:uu:diva-363062 (URN)10.1111/cid.12627 (DOI)000440988300022 ()29920935 (PubMedID)
    Available from: 2018-10-18 Created: 2018-10-18 Last updated: 2018-10-28Bibliographically approved
    2. 8-11-year follow-up of immediately loaded implants placed in edentulous maxillae with compromised bone volume and poor bone quality: A prospective cohort study
    Open this publication in new window or tab >>8-11-year follow-up of immediately loaded implants placed in edentulous maxillae with compromised bone volume and poor bone quality: A prospective cohort study
    2018 (English)In: Article in journal (Refereed) Submitted
    National Category
    Dentistry
    Identifiers
    urn:nbn:se:uu:diva-364439 (URN)
    Available from: 2018-10-28 Created: 2018-10-28 Last updated: 2018-10-28
    3. Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting
    Open this publication in new window or tab >>Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting
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    2016 (English)In: Research in Veterinary Science, ISSN 0034-5288, E-ISSN 1532-2661, Vol. 107, p. 123-131Article in journal (Refereed) Published
    Abstract [en]

    In connection with bilateral maxillary sinus augmentation, the acute effects of the nonsteroidal anti-inflammatory drug carprofen on facial expressions and long-term effects on bone formation were evaluated in 18 male New Zealand White rabbits. A 10 x 10 mm bone window was drilled in the maxilla, the sinus membrane elevated and a titanium mini-implant inserted. One of two test materials was randomly inserted unilaterally and bovine bone chips (control) on the contralateral side in the created space. Rabbits were randomly allocated to receive buprenorphine plus carprofen (n = 9) or buprenorphine plus saline (n = 9) postoperatively. Buprenorphine was administered subcutaneously every 6 h for 3 days in a tapered dose (0.05-0.01 mg/kg) and carprofen (5 mg/kg) or saline administered subcutaneously 1 h before, and daily for 4 days postoperatively. To assess pain, clinical examination, body weight recording and scoring of facial expressions from photos taken before, and 6-13 h after surgery were performed. Twelve weeks after surgery the rabbits were euthanized and sections of maxillary bones and sinuses were analysed with histomorphometry and by qualitative histology. Carprofen had no effect on mean facial expression scores, which increased from 0.0 to 3.6 (carprofen) and 43 (saline), of a maximum of 8.0. Neither did carprofen have an effect on bone formation or implant incorporation, whereas the test materials had. In conclusion, treatment with 5 mg/kg carprofen once daily for 5 days did not reduce facial expression scores after maxillary sinus augmentation in buprenorphine treated rabbits and did not affect long term bone formation.

    Keywords
    Bone formation, Pain, NSAID, Implant, Sinus-lift, Experimental animal
    National Category
    Veterinary Science
    Identifiers
    urn:nbn:se:uu:diva-304437 (URN)10.1016/j.rvsc.2016.05.010 (DOI)000381541600019 ()27473985 (PubMedID)
    Funder
    Swedish Research Council, VR2013_6373 MR
    Available from: 2016-10-05 Created: 2016-10-05 Last updated: 2018-10-28Bibliographically approved
    4. A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model
    Open this publication in new window or tab >>A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model
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    2018 (English)In: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 70, p. 31-39Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVES: The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid-calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model.

    MATERIAL AND METHODS: Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralateral side. In a sinus lift, the sinus mucosa was elevated and a titanium mini-implant was placed in the alveolar bone. Augmentation material (CPC, HABP·CaP or bovine bone) was applied in the space around the implant. The rabbits were euthanized three months after surgery and qualitative and histomorphometric evaluation were conducted. Histomorphometric evaluation included three different regions of interest (ROIs) and the bone to implant contact on each installed implant.

    RESULTS: Qualitative assessment (p = <.05), histomorphometric evaluations (p = < .01), and implant incorporation (p = <.05) showed that CPC and bovine mineral induced similar amount of bone and more than the HABP·CaP hydrogel.

    CONCLUSION: CPC induced similar amount of bone as bovine mineral and both materials induced more bone than HABP·CaP hydrogel.

    CLINICAL SIGNIFICANCE: The CPC is suggested as a synthetic alternative for augmentations in the maxillofacial area.

    Keywords
    Animal experiments, Bone implant interactions, Bone regeneration, Bone substitutes, Ceramic granules
    National Category
    Dentistry
    Identifiers
    urn:nbn:se:uu:diva-341457 (URN)10.1016/j.jdent.2017.12.009 (DOI)000425888900004 ()29258851 (PubMedID)
    Available from: 2018-02-09 Created: 2018-02-09 Last updated: 2018-10-28Bibliographically approved
    5. Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
    Open this publication in new window or tab >>Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
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    (English)In: Article, review/survey (Refereed) Submitted
    National Category
    Surgery Medical Biotechnology
    Identifiers
    urn:nbn:se:uu:diva-364438 (URN)
    Available from: 2018-10-28 Created: 2018-10-28 Last updated: 2018-10-28
  • Svensson, Maria
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Romance Languages.
    Norén, Coco
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Romance Languages.
    La voix publique et les pronoms dits « indéfinis »2018In: Studia Neophilologica, ISSN 0039-3274, E-ISSN 1651-2308Article in journal (Refereed)
    Abstract [fr]

    Cette étude vise à examiner la présence de la voix publique, associéeaux citoyens, dans les discours des membres du Parlement européen,et plus particulièrement la manière dont cette voix publique se manifestepar l’emploi de pronoms indéfinis de totalité humaine, notammenttous, tout le monde, chacun et on. L’étude indique que leuremploi dans les interventions de débats des membres du Parlementeuropéen permet de distinguer des différences sémantiques entre cesquatre pronoms. En développant la discussion sur une corrélationéventuelle entre les valeurs de définitude et de totalité, nous proposons,à la base de paramètres cotextuels, une précision du degré dedéfinitude des pronoms étudiés. L’analyse confirme également desdifférences entre les pronoms quant à leur valeur de totalité, selon leurcaractère plutôt totalisant ou distributif, chacun étant selon cetteanalyse considéré comme plus indéfini et plus distributif que tout lemonde.

  • Pazoki, Meysam
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Edvinsson, Tomas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Metal replacement in perovskite solar cell materials: chemical bonding effects and optoelectronic properties2018In: SUSTAINABLE ENERGY & FUELS, ISSN 2398-4902, Vol. 2, no 7, p. 1430-1445Article, review/survey (Refereed)
    Abstract [en]

    The composition of lead halide perovskite materials has been explored extensively over the last few years and as a consequence, different materials have been introduced into the perovskite solar cell family with diverse physical properties. Herein, we present recent progress within the framework of lead replacement that has led to new solar cell compounds by partial exchange or full substitution of lead with other metals. Lead replacement with divalent metals, tin and germanium perovskites as well as alkaline earth metals, and lanthanides are reviewed and discussed with respect to the chemical bonding effects and their relationship with the optoelectronic and charge mobility properties. The physical properties of the materials and the related device performances are also discussed with respect to the metal cation bonding within the perovskite lattice using transition metals and monovalent and trivalent metals.

  • Accordini, Simone
    et al.
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Calciano, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Johannessen, Ane
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Portas, Laura
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Benediktsdottir, Bryndis
    Univ Iceland, Fac Med, Reykjavik, Iceland.
    Bertelsen, Randi Jacobsen
    Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Braback, Lennart
    Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden.
    Carsin, Anne-Elie
    Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud PUbl CIBERESP, Barcelona, Spain.
    Dharmage, Shyamali C.
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy;Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Dratva, Julia
    ZHAW Sch Hlth Profess, Inst Hlth Sci, Winterthur, Switzerland;Basel Univ, Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.
    Forsberg, Bertil
    Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden.
    Real, Francisco Gomez
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Heinrich, Joachim
    Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat,Social & Environm, Munich, Germany.
    Holloway, John W.
    Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England.
    Holm, Mathias
    Univ Gothenburg, Sahlgrenska Acad, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Leynaert, Benedicte
    INSERM, Pathophysiol & Epidemiol Resp Dis, UMR 1152, Paris, France.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Martinez-Moratalla Rovira, Jesus
    CHUA, Hlth Serv Castilla La Mancha SESCAM, Pneumol Serv, Albacete, Spain;Univ Castilla La Mancha, Sch Med, Albacete, Spain.
    Raherison, Chantal
    Bordeaux Univ, INSERM, U1219, Bordeaux, France.
    Luis Sanchez-Ramos, Jose
    Univ Huelva, Dept Nursing, Huelva, Spain.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark;Natl Res Ctr Working Environm, Copenhagen, Denmark.
    Bono, Roberto
    Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy.
    Corsico, Angelo G.
    Univ Pavia, IRCCS San Matteo Hosp Fdn, Div Resp Dis, Pavia, Italy.
    Demoly, Pascal
    Univ Montpellier, Hop Arnaud Villeneuve, Dept Pneumol & Addictol, Montpellier, France;Sorbonne Univ, INSERM, IPLESP, Paris, France.
    Dorado Arenas, Sandra
    Galdakao Usansolo Hosp, Pulmonol Dept, Biscay, Spain.
    Nowak, Dennis
    Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat,Social & Environm, Munich, Germany;Comprehens Pneumol Ctr Munich, German Ctr Lung Res, Munich, Germany.
    Pin, Isabelle
    CHU Grenoble Alpes, Pediat, Grenoble, France;Inst Adv Biosci, INSERM 1209, Grenoble, France;Univ Grenoble Alpes, Grenoble, France.
    Weyler, Joost
    Univ Antwerp, Dept Epidemiol & Social Med, Antwerp, Belgium;Univ Antwerp, StatUA Stat Ctr, Antwerp, Belgium.
    Jarvis, Deborah
    Imperial Coll, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England.
    Svanes, Cecilie
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Ageing, Lungs European Cohorts A. L. E. C. Study
    A three-generation study on the association of tobacco smoking with asthma2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, no 4, p. 1106-1117Article in journal (Refereed)
    Abstract [en]

    Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged <= 51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.

  • Lombardi, Stefano
    et al.
    Uppsala University, Units outside the University, Office of Labour Market Policy Evaluation. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies.
    Nordström Skans, Oskar
    Uppsala University, Units outside the University, Office of Labour Market Policy Evaluation. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies.
    Vikström, Johan
    Uppsala University, Units outside the University, Office of Labour Market Policy Evaluation. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies.
    Targeted wage subsidies and firm performance2018In: Labour Economics, ISSN 0927-5371, E-ISSN 1879-1034, Vol. 53, p. 33-45Article in journal (Refereed)
    Abstract [en]

    This paper studies how targeted wage subsidies affect the performance of the recruiting firms. Using Swedish administrative data from the period 1998-2008, we show that treated firms substantially outperform other recruiting firms after hiring through subsidies, despite identical pre-treatment performance levels and trends in a wide set of key dimensions. The pattern is less clear from 2007 onwards, after a reform removed the involvement of caseworkers from the subsidy approval process. Overall, our results suggest that targeted employment subsidies can have large positive effects on post-match outcomes of the hiring firms, at least if the policy environment allows for pre-screening by caseworkers.

  • Larsen, Sandra
    et al.
    Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskag, Norway;Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway.
    Haavaldsen, Camilla
    Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskag, Norway.
    Bjelland, Elisabeth Krefting
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskag, Norway.
    Dypvik, Johanne
    Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskag, Norway;Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway.
    Jukic, Anne Marie
    Yale Univ, Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA.
    Eskild, Anne
    Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskag, Norway;Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway.
    Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, no 4, p. 1141-1150Article in journal (Refereed)
    Abstract [en]

    Background: We studied associations of number of daily cigarettes in the first trimester with placental weight and birthweight in women who smoked throughout pregnancy, and in women who stopped smoking after the first trimester. Methods: We included all women with delivery of a singleton in Norway (n = 698 891) during 1999-2014, by using data from the Medical Birth Registry of Norway. We assessed dose-response associations by applying linear regression with restricted cubic splines. Results: In total, 12.6% smoked daily in the first trimester, and 3.7% stopped daily smoking. In women who smoked throughout pregnancy, placental weight and birthweight decreased by number of cigarettes; however, above 11-12 cigarettes we estimated no further decrease (Pnon-linearity < 0.001). Maximum decrease in placental weight in smokers compared with non-smokers was 18.2 g [ 95% confidence interval (CI): 16.6 to 19.7], and for birthweight the maximum decrease was 261.9 g (95% CI: 256.1 to 267.7). In women who stopped smoking, placental weight was higher than in non-smokers and increased by number of cigarettes to a maximum of 16.2 g (95% CI: 9.9 to 22.6). Birthweight was similar in women who stopped smoking and non-smokers, and we found no change by number of cigarettes (Pnon-linearity < 0.001). Conclusions: In women who smoked throughout pregnancy, placental weight and birthweight decreased non-linearly by number of cigarettes in the first trimester. In women who stopped smoking, placental weight was higher than in non-smokers and increased linearly by number of cigarettes; birthweight was almost similar to that of non-smokers.

  • Zanetti, Daniela
    et al.
    Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, 300 Pasteur Dr,Mail Code 5773, Stanford, CA 94305 USA;Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
    Tikkanen, Emmi
    Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, 300 Pasteur Dr,Mail Code 5773, Stanford, CA 94305 USA.
    Gustafsson, Stefan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford University School of Medicine, CA..
    Priest, James R.
    Stanford Univ, Sch Med, Div Cardiol, Dept Pediat, Stanford, CA 94305 USA.
    Burgess, Stephen
    Univ Cambridge, Biostat Unit, MRC, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, 300 Pasteur Dr,Mail Code 5773, Stanford, CA 94305 USA;Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
    Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease Addressing the Barker Hypothesis With Mendelian Randomization2018In: CIRCULATION-GENOMIC AND PRECISION MEDICINE, ISSN 2574-8300, Vol. 11, no 6, article id UNSP e002054Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower birthweight is causal for these diseases, but causality is difficult to infer from observational studies. METHODS: We performed regression analyses to assess associations of birthweight with cardiovascular disease and T2D in 237 631 individuals from the UK Biobank. Further, we assessed the causal relationship of such associations using Mendelian randomization. RESULTS: In the observational analyses, birthweight showed inverse associations with systolic and diastolic blood pressure (beta, -0.83 and -0.26; per raw unit in outcomes and SD change in birthweight; 95% confidence interval [CI], -0.90 to -0.75 and -0.31 to -0.22, respectively), T2D (odds ratio, 0.83; 95% CI, 0.79-0.87), lipid-lowering treatment (odds ratio, 0.84; 95% CI, 0.81-0.86), and coronary artery disease (hazard ratio, 0.85; 95% CI, 0.78-0.94), whereas the associations with adult body mass index and body fat (beta, 0.04 and 0.02; per SD change in outcomes and birthweight; 95% CI, 0.03-0.04 and 0.01-0.02, respectively) were positive. The Mendelian randomization analyses indicated inverse causal associations of birthweight with low-density lipoprotein cholesterol, 2-hour glucose, coronary artery disease, and T2D and positive causal association with body mass index but no associations with blood pressure. CONCLUSIONS: Our study indicates that lower birthweight, used as a proxy for intrauterine growth retardation, is causally related with increased susceptibility to coronary artery disease and T2D. This causal relationship is not mediated by adult obesity or hypertension.

  • Augstein, Frauke
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Physiological Botany.
    Carlsbecker, Annelie
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Physiological Botany.
    Getting to the Roots: A Developmental Genetic View of Root Anatomy and Function From Arabidopsis to Lycophytes2018In: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 9, article id 1410Article, review/survey (Refereed)
    Abstract [en]

    Roots attach plants to the ground and ensure efficient and selective uptake of water and nutrients. These functions are facilitated by the morphological and anatomical structures of the root, formed by the activity of the root apical meristem (RAM) and consecutive patterning and differentiation of specific tissues with distinct functions. Despite the importance of this plant organ, its evolutionary history is not clear, but fossils suggest that roots evolved at least twice, in the lycophyte (clubmosses and their allies) and in the euphyllophyte (ferns and seed plants) lineages. Both lycophyte and euphyllophyte roots grow indeterminately by the action of an apical meristem, which is protected by a root cap. They produce root hairs, and in most species the vascular stele is guarded by a specialized endodermal cell layer. Hence, most of these traits must have evolved independently in these lineages. This raises the question if the development of these apparently analogous tissues is regulated by distinct or homologous genes, independently recruited from a common ancestor of lycophytes and euphyllophytes. Currently, there are few studies of the genetic and molecular regulation of lycophyte and fern roots. Therefore, in this review, we focus on key regulatory networks that operate in root development in the model angiosperm Arabidopsis. We describe current knowledge of the mechanisms governing RAM maintenance as well as patterning and differentiation of tissues, such as the endodermis and the vasculature, and compare with other species. We discuss the importance of comparative analyses of anatomy and morphology of extant and extinct species, along with analyses of gene regulatory networks and, ultimately, gene function in plants holding key phylogenetic positions to test hypotheses of root evolution.

  • Eriksson, Annie
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Åverling, Ulrika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Motivation till föränding hos vårdsökande: Kvalificerade rådgivande samtal med distriktssköterska2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Ohälsosamma levnadsvanorna ökar i befolkningen. Socialstyrelsen rekommenderar kvalificerade rådgivande samtal gällande distriktssköterskans arbete med levnadsvanor men anger inte samtalsmetod. Inom primärvård är motiverande samtal (MI) vanligt använd. Denna samtalsmetod förordas av Folkhälsomyndigheten, men inte av Nationella riktlinjer för diabetesvård. Detta då MI inte visat effekt på HbA1c-värde och kroppsvikt. Hur vårdsökande själva ser på samtal med distriktssköterska och vad som motiverat dem till förändringar är sparsamt studerat.

    Syfte: Syftet med studien är att undersöka vad som har motiverat vårdsökande till förändring i de kvalificerade rådgivande samtal de haft med distriktssköterska inom primärvård.

    Metod: Studien har en deskriptiv design med kvalitativ ansats i form av intervjustudie med tolv vårdsökande. Intervjuerna, som var semistrukturerade, spelades in, transkriberades ordagrant och analyserades därefter med en innehållsanalys.

    Resultat: Som svar på syftet framkom under analysen ett övergripande tema, två kategorier och fyra subkategorier. Det övergripande temat visade att ett samspel behövs mellan vårdsökande och distriktssköterska för att skapa motivation till förändring. Samspelet bygger på att den vårdsökande får ny lärdom som ger inre motivation och att det skapas en god relation med distriktssköterskan.

    Slutsats: Att distriktssköterskans arbetstid ägnas åt kvalificerade rådgivande samtal är enligt föreliggande resultat värdefullt för att vårdsökande ska hitta motivation till förändring. Motivationen kom av lärdom införskaffad i samspel med en god relation med distriktssköterskan som den vårdsökande haft hälsosamtal med. Att primärvården erbjuder kvalificerade rådgivande samtal med distriktssköterskan kan ge en vinst på både individ-, grupp- och samhällsnivå. 

  • Johansson, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Grönlund, Niclas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Fysisk aktivitet som behandling vid egentlig depression: Litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Egentlig depression är den vanligaste psykiska sjukdomen i världen. Depression kan leda till lidande och död och samhällskostnaderna för depression stiger för varje år. Den nuvarande behandlingen är väl beprövad, men vidare forskning för att hitta effektiva behandlingsmetoder för depression behövs. Syfte: Syftet med den här studien var att undersöka hur fysisk aktivitet påverkar hälsan hos personer med depression och hur detta kan yttra sig. Metod: En litteraturstudie gjordes i databaserna Pubmed och SBU. Totalt identifierades 54 artiklar och 12 artiklar analyserades i full text. Granskning och analys av artiklarna genomfördes för att få fram bärande kategorier. Dorothea Orems egenvårdsteori användes som teoretisk ram. Resultat: Fysisk aktivitet har en positiv påverkan på depressiva symtom. I flera av studierna som undersöktes minskade symtom på depression efter fysisk aktivitet. Minskningen var oberoende av vilken typ av träningsform eller intensiteten i aktiviteten som genomfördes. Fysisk aktivitet vid egentlig depression hade positiv effekt på den fysiska hälsan där immunförsvaret stärktes och inflammatoriska markörer minskade. Slutsats: Fysisk aktivitet kan vara en användbar behandlingsform inom vården för att hjälpa deprimerade att lindra symtom på depression och minska riskerna för kroppsliga åkommor hos denna patientgrupp.

  • Hagström, Charlotta
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Veronica, Andersson
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Betydelsen av sociala media för barns och ungdomars psykiska hälsa2018Independent thesis Advanced level (degree of Master (One Year)), 40 credits / 60 HE creditsStudent thesis
  • Public defence: 2018-12-15 11:00 Ihresalen, Uppsala
    Odyniec, Pawel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Engaging Advaita: Conceptualising liberating knowledge in the face of Western modernity2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This dissertation is a study of modern Indian philosophy. It examines three engaging articulations of the Advaitic notion of liberating knowledge or brahmajñāna provided by three prominent Indian philosophers of the twentieth century, namely, Badrīnāth Śukla (1898-1988), Krishnachandra Bhattacharyya (1875-1949), and Sarvepalli Radhakrishnan (1888-1975). Particular attention is paid to the existing relation between their distinctive conceptualisations of liberating knowledge and the doxastic attitudes that these authors professed towards the Sanskrit intellectual past of South Asia and the presence of the Western Other.

    In the main, it argues that the profound differences to be found, on the one hand, in Śukla’s elucidation of this key Advaitic notion and, on the other, in Bhattacharyya’s and Radhakrishnan’s take on the same, betray their commitment to two radically different doxastic attitudes. Classifying these into (a) non-dialogical and (b) dialogical in relation to the Western Other as well as into (c) exegetic and (d) hermeneutic in relation to the Sanskrit intellectual past of South Asia, it contends that, in comparison to the conceptual scheme and the parameters of intelligibility that shaped and underpinned the precolonial Advaitic discourse on brahmajñāna in Sanskrit, there is a certain kind of epistemic discontinuity in the dialogical cum hermeneutic stance taken by Bhattacharyya and Radhakrishnan that is not to be found in the non-dialogical cum exegetic engagement enacted by Śukla. It suggests that this particular sort of discontinuity, absent as it is from Śukla’s elucidation of the process of knowing Brahman, reflects the far-reaching commitment of Krishnachandra Bhattacharyya and Sarvepalli Radhakrishnan to appropriate the precolonial Advaitic notion of liberating knowledge hermeneutically and to conceptualise it in the face of Western modernity, that is, rendering it meaningful in terms and within the parameters of intelligibility of the Western Other in order to contest what they took to be a troublesome predicament of Western modernity.

    By examining their ways of engaging with the Advaitic notion of liberating knowledge, this dissertation contributes to the on-going debate about the nature and the driving forces of modern Indian philosophy.

  • Public defence: 2018-12-17 13:00 B42, Uppsala
    Papoutsoglou, Panagiotis
    Uppsala University, Science for Life Laboratory, SciLifeLab.
    Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. In contrast, TGFβ, induces epithelial to mesenchymal transition (EMT), a normal embryonic process which is employed by advanced cancers, in order to acquire mesenchymal traits and metastasize.

    Bone morphogenetic protein (BMP) family members belong to the TGFβ superfamily and are involved in cell differentiation, development and bone formation.

    Non-coding RNAs (ncRNAs) are not translated into proteins, are important regulators of gene expression and physiological processes and are often de-regulated in cancer. They control gene expression through physical association with chromatin, DNA, RNA molecules or proteins.

    Poly(ADP-ribose) polymerases (PARPs) catalyze the poly (ADP)-ribosylation of proteins, whereas the enzyme poly(ADP-ribose) glycohydrolase (PARG) removes ADP-ribose units. Members of the PARP family function in the DNA damage response, regulation of transcription and cell death.

    In this thesis, we investigated the importance of the TGFβ signaling pathway in regulating the expression of long non-coding RNAs (lncRNAs). We identified TGFβ-regulated lncRNAs and observed that a substantial number of them act in a feedback loop to modulate the magnitude of TGFβ signaling. Interestingly, the nuclear lncRNA TGFB2-antisense RNA 1 (TGFB2-AS1) is induced by TGFβ and negatively regulates expression of members of the TGFβ and BMP pathways, through interaction with EED, a protein of the polycomb repressor complex 2 (PRC2). Also, TGFβ signaling promoted the expression of mir-100-let-7a-2-mir-125b-1 cluster host gene (MIR100HG), which enhanced TGFβ signaling and affected TGFβ-mediated cell cycle arrest. The MIR100HG-derived miRNAs let-7a-2-3p, miR125b-5p and miR-125b-1-3p, were also induced by TGFβ. In contrast, the long intergenic non-protein coding RNA 707 (LINC00707), was reduced in response to TGFβ and affected the expression of a group of genes related to inflammatory responses and interferon-γ (IFN-γ) signaling.

    We also report that TGFβ and BMP pathways are regulated by ADP-ribosylation of Smad proteins, the signaling mediators of these pathways. We observed that PARP1 and PARP2 attenuated, while PARG favored TGFβ signaling. Furthermore, PARP1 negatively regulated BMP signaling, by ADP-ribosylating Smad1 and Smad5, whereas PARG enhanced BMP signaling by de-ADP-ribosylating Smads.

    Collectively, we provide evidence that lncRNAs and ADP-ribosylating enzymes modulate TGFβ and BMP signaling pathways and propose models for their molecular mechanisms and functional roles.

    List of papers
    1. The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
    Open this publication in new window or tab >>The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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    2018 (English)Article in journal (Refereed) Submitted
    Abstract [en]

    LncRNAs regulate cell function through many physiological processes. We have identified lncRNAs whose expression is regulated by transforming growth factor β (TGFβ), by a transcriptomic screen. We focused on TGFB2-antisense RNA1 (TGFB2-AS1), which was induced by TGFβ through Smad and protein kinase pathways, and exhibited predominantly nuclear localization. Depleting TGFB2-AS1 enhanced TGFβ/Smad-mediated transcription and expression of the TGFβ-target genes FN1 and SERPINE1. Overexpression of TGFB2-AS1 reduced expression of these genes, attenuated TGFβ-induced cell growth arrest, and altered BMP and Wnt pathway gene profiles. Mechanistically, TGFB2-AS1 mainly via its 3’ terminal region, bound to EED, an adaptor of the Polycomb repressor complex 2 (PRC2), promoting repressive histone H3K27me3 modifications at TGFβ-target gene promoters. Silencing EED or inhibiting PRC2 methylation activity, partially rescued TGFB2-AS1 mediated gene repression. Our observations support the notion that TGFB2-AS1 is a TGFβ-induced lncRNA with inhibitory functions on TGFβ and BMP pathways output, constituting an auto-regulatory negative feedback mechanism that balances TGFβ- and BMP-mediated responses.

    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-363700 (URN)
    Available from: 2018-10-20 Created: 2018-10-20 Last updated: 2018-12-03
    2. TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses
    Open this publication in new window or tab >>TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses
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    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The class of long non-coding RNAs (lncRNAs) consists of RNA molecules, which lack protein coding potential and regulate a wide variety of cellular processes. At the molecular level, lncRNAs act as regulators of gene expression by interacting with chromatin, other types of RNA or proteins. Transforming growth factor β (TGFβ) plays pivotal roles in diverse biological processes, such as cell growth arrest, embryonic development and regulation of the immune system. In this study, we describe the long intergenic non-protein coding RNA 707 (LINC00707) as a TGFβ responsive gene. By combining transcriptomic data from human keratinocytes and glioblastoma cancer stem cells, we observed that TGFβ signaling down-regulates the expression of LINC00707. RNA sequencing revealed that in keratinocytes knockdown of LINC00707 or stimulation by TGFβ, affected expression of genes involved in inflammatory responses and interferon-γ-mediated signaling. In summary, we suggest that the immune suppressive actions of TGFβ involve suppression of the pro-inflammatory LINC00707.

    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-363898 (URN)
    Available from: 2018-10-19 Created: 2018-10-19 Last updated: 2018-12-03
    3. The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β
    Open this publication in new window or tab >>The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Transforming growth factor β (TGFβ) stimulation modulates the expression of many epithelial genes involved in cell growth arrest, epithelial-to-mesenchymal transition and development. Many recent reports provide evidence that TGFβ signaling regulates the expression of long non-coding RNAs (lncRNAs), i.e. RNAs lacking protein coding potential. After screening for lncRNAs whose expression is regulated by TGFβ signaling, we observed that TGFβ induced the expression of the mir-100-let-7a-2-mir-125b-1 cluster host gene (MIR100HG), a genetic locus which gives rise to multiple lncRNAs (MIR100HG splice variants), as well as the micro-RNA clusters miR-100, let-7a-2 and miR-125b-1. In addition, TGFβ stimulation led to increased levels of mature let-7a-2-3p, miR-125b-5p and miR-125b-1-3p miRNAs. MIR100HG depletion attenuated the TGFβ/Smad-mediated transcriptional responses, the expression of the TGFβ-target genes SERPINE1 (PAI-1) and fibronectin 1 (FN1), and TGFβ-mediated cell growth arrest. Moreover, overexpressing let-7a-2-3p, but not miR-125b-5p or miR-125b-1-3p miRNAs, mimicked enhanced TGFβ/Smad-mediated transcription and inhibited cell proliferation, while inhibition of let-7a-2-3p slightly reduced PAI-1 and fibronectin expression. Thus, we identified MIR100HG and the miRNA clusters generated by its locus as TGFβ-target non-coding RNAs, and ascribed to them a potential role in mediating cytostatic responses by modulating the magnitude of TGFβ signaling.

    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-363899 (URN)
    Available from: 2018-10-19 Created: 2018-10-19 Last updated: 2018-10-23
    4. Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
    Open this publication in new window or tab >>Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
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    2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 8, p. e103651-Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND:

    Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation. We previously reported that ADP-ribosylation of Smads by poly(ADP-ribose) polymerase 1 (PARP-1) negatively influences Smad-mediated transcription. PARP-1 is known to functionally interact with PARP-2 in the nucleus and the enzyme poly(ADP-ribose) glycohydrolase (PARG) can remove poly(ADP-ribose) chains from target proteins. Here we aimed at analyzing possible cooperation between PARP-1, PARP-2 and PARG in regulation of TGFβ signaling.

    METHODS:

    A robust cell model of TGFβ signaling, i.e. human HaCaT keratinocytes, was used. Endogenous Smad3 ADP-ribosylation and protein complexes between Smads and PARPs were studied using proximity ligation assays and co-immunoprecipitation assays, which were complemented by in vitro ADP-ribosylation assays using recombinant proteins. Real-time RT-PCR analysis of mRNA levels and promoter-reporter assays provided quantitative analysis of gene expression in response to TGFβ stimulation and after genetic perturbations of PARP-1/-2 and PARG based on RNA interference.

    RESULTS:

    TGFβ signaling rapidly induces nuclear ADP-ribosylation of Smad3 that coincides with a relative enhancement of nuclear complexes of Smads with PARP-1 and PARP-2. Inversely, PARG interacts with Smads and can de-ADP-ribosylate Smad3 in vitro. PARP-1 and PARP-2 also form complexes with each other, and Smads interact and activate auto-ADP-ribosylation of both PARP-1 and PARP-2. PARP-2, similar to PARP-1, negatively regulates specific TGFβ target genes (fibronectin, Smad7) and Smad transcriptional responses, and PARG positively regulates these genes. Accordingly, inhibition of TGFβ-mediated transcription caused by silencing endogenous PARG expression could be relieved after simultaneous depletion of PARP-1.

    CONCLUSION:

    Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFβ signaling.

    National Category
    Clinical Medicine
    Identifiers
    urn:nbn:se:uu:diva-231920 (URN)10.1371/journal.pone.0103651 (DOI)000341302700014 ()25133494 (PubMedID)
    Available from: 2014-09-11 Created: 2014-09-11 Last updated: 2018-10-23Bibliographically approved
    5. Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation
    Open this publication in new window or tab >>Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation
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    2016 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 291, no 24, p. 12706-12723Article in journal (Refereed) Published
    Abstract [en]

    We previously established a mechanism of negative regulation of transforming growth factor beta signaling mediated by the nuclear ADP-ribosylating enzyme poly-(ADP-ribose) polymerase 1 (PARP1) and the deribosylating enzyme poly-(ADP-ribose) glycohydrolase (PARG), which dynamically regulate ADP-ribosylation of Smad3 and Smad4, two central signaling proteins of the pathway. Here we demonstrate that the bone morphogenetic protein (BMP) pathway can also be regulated by the opposing actions of PARP1 and PARG. PARG positively contributes to BMP signaling and forms physical complexes with Smad5 and Smad4. The positive role PARG plays during BMP signaling can be neutralized by PARP1, as demonstrated by experiments where PARG and PARP1 are simultaneously silenced. In contrast to PARG, ectopic expression of PARP1 suppresses BMP signaling, whereas silencing of endogenous PARP1 enhances signaling and BMP-induced differentiation. The two major Smad proteins of the BMP pathway, Smad1 and Smad5, interact with PARP1 and can be ADP-ribosylated in vitro, whereas PARG causes deribosylation. The overall outcome of this mode of regulation of BMP signal transduction provides a fine-tuning mechanism based on the two major enzymes that control cellular ADP-ribosylation.

    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-299724 (URN)10.1074/jbc.M116.729699 (DOI)000378119900024 ()27129221 (PubMedID)
    Funder
    Swedish Research Council, K2010-67X-14936-07-3 K2013-66X-14936-10-5
    Available from: 2016-07-26 Created: 2016-07-26 Last updated: 2018-10-23Bibliographically approved
  • Public defence: 2018-12-15 13:00 Auditorium minus, Uppsala
    Grip, Olivia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery. Välj ....
    Acute limb ischaemia: Treatment, outcome and time trends2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Acute limb ischaemia (ALI) is a frequent emergency associated with high rates of amputation and death. Traditionally, patients with ALI were treated with open surgical removal of the occlusion or bypass surgery. During the past few decades, new endovascular techniques developed.  

    No larger studies have investigated the optimal contemporary treatment for patients with ALI. Today, there are no international consensus for recommendations for the treatment of ALI, leaving it open to every surgeon or department to decide the best treatment option. 

    This thesis aimed to study patients with ALI as a means to extend the understanding of this group of patients, as well as to investigate treatment options. Data sources included hospital charts or information was gathered from the Swedish nationwide Vascular Registry (Swedvasc), the Swedish Population Registry for deaths and the Swedish Patient Registry for amputations.

    Paper I compared the results from thrombolysis with and without continuous heparin infusion in 749 thrombolytic procedures, concluding that both treatment strategies were equally successful in achieving revascularisation, with acceptable complication rates for both strategies. Continuous heparin infusion during intra-arterial thrombolysis offered no advantage. Although the regime with continuous heparin infusion was associated with a higher frequency of bleeding complications (p<0.001), this difference disappeared after adjustment for confounders.

    Paper II studied long-term outcome after thrombolysis and showed that thrombolytic therapy achieves good medium- and long-term clinical outcome, which reduces the need for open surgical treatment in most patients. More than half of the patients in paper II did not require any surgical reintervention or amputation in their remaining lifetime or during a mean of 6.2 years of follow-up. Long-term outcome differed between the aetiological groups. This information is valuable when deciding on the optimal treatment strategy for patients with ALI.

    Paper III compared outcomes after open and endovascular revascularisation for the treatment of ALI in 16,229 patients treated in 1994-2014. The large propensity score-matched nationwide cohort study revealed that endovascular treatment of ALI was associated with significantly better short-term survival and amputation-free survival compared with open revascularisation.

    Paper IV investigated acute aortic occlusion (AAO) and subsequent ALI. This study showed that mortality after AAO is high but has improved in the past 20 years. The proportion of AAO secondary to occluded graft/stent/stentgrafts increases over time as a result of the endovascular shift in treating aortic diseases and the proportion of AAO secondary to native artery thrombosis decreases.

    Taken together, the main findings of this thesis demonstrate a gradual improvement in survival and that endovascular techniques are becoming more frequently used as a first- line treatment of patients with ALI.

    List of papers
    1. Outcome and complications after intra-arterial thrombolysis for lower limb ischaemia with or without continuous heparin infusion
    Open this publication in new window or tab >>Outcome and complications after intra-arterial thrombolysis for lower limb ischaemia with or without continuous heparin infusion
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    2014 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 101, no 9Article in journal (Refereed) Published
    Abstract [en]

    Background

    Thrombolysis is a common treatment for acute leg ischaemia. The purpose of this study was to evaluate different thrombolytic treatment strategies, and risk factors for complications

    This was a retrospective analysis of prospective databases from two vascular centres. One centre used a higher dose of heparin and recombinant tissue plasminogen activator (rtPA).

    Results

    Some 749 procedures in 644 patients of median age 73 years were studied; 353 (47·1 per cent) of the procedures were done in women. The aetiology of ischaemia was graft occlusion in 38·8 per cent, acute arterial thrombosis in 32·2 per cent, embolus in 22·3 per cent and popliteal aneurysm in 6·7 per cent. Concomitant heparin infusion was used in 63·2 per cent. The mean dose of rtPA administered was 21·0 mg, with a mean duration of 25·2 h. Technical success was achieved in 80·2 per cent. Major amputation and death within 30 days occurred in 13·1 and 4·4 per cent respectively. Bleeding complications occurred in 227 treatments (30·3 per cent). Blood transfusion was needed in 104 (13·9 per cent). Three patients (0·4 per cent of procedures) had intracranial bleeding; all were fatal. Amputation‐free survival was 83·6 per cent at 30 days at both centres. In multivariable analysis, preoperative severe ischaemia with motor deficit was the only independent risk factor for major bleeding (odds ratio (OR) 2·98; P <0·001). Independent risk factors for fasciotomy were severe ischaemia (OR 2·94) and centre (OR 6·50). Embolic occlusion was protective for major amputation at less than 30 days (OR 0·30; P = 0·003). Independent risk factors for death within 30 days were cerebrovascular disease (OR 3·82) and renal insufficiency (OR 3·86).

    Conclusion

    Both treatment strategies were successful in achieving revascularization with acceptable complication rates. Continuous heparin infusion during intra‐arterial thrombolysis appeared to offer no advantage.

    Place, publisher, year, edition, pages
    Uppsala: , 2014
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-360872 (URN)10.1002/bjs.9579 (DOI)
    Available from: 2018-09-19 Created: 2018-09-19 Last updated: 2018-12-12Bibliographically approved
    2. Long-term Outcome after Thrombolysis for Acute Lower Limb Ischaemia
    Open this publication in new window or tab >>Long-term Outcome after Thrombolysis for Acute Lower Limb Ischaemia
    2017 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 53, no 6, p. 853-861Article in journal (Refereed) Published
    Abstract [en]

    Objectives: The purpose was to study long-term outcome after thrombolysis for acute arterial lower limb ischaemia, and to evaluate the results depending on the underlying aetiology of arterial occlusion.

    Methods: This was a retrospective study of patients entered into a prospective database. Patients were identified in prospective databases from two vascular centres, including a large number of variables. Case records were analysed retrospectively. Through cross linkage with the Population Registry 100% accurate survival data were obtained. Between January 2001 and December 2013, 689 procedures were included. The aetiology of ischaemia was graft/stent/stent graft occlusion in 39.8%, arterial thrombosis in 27.7%, embolus in 25.1% and popliteal aneurysm in 7.4%.

    Results: The mean follow-up was 59.4 months (95% CI, 56.1-62.7), during which 32.9% needed further re interventions, 16.4% underwent amputation without re-intervention, and 50.7% had no re-intervention. The need for re-intervention during follow-up was 48.0% in the graft/stent occlusions group, 34.0% of the popliteal aneurysm group, 25.4% in the thrombosis group, and 16.3% in the embolus group (p < .001). The overall primary patency rates were 69.1% and 55.9% at 1 and 5 years, respectively. Primary patency at 5 years was higher for the embolus group (83.3%, p = .002) and lower for the occluded graft/stent group (43.3%, p < .001). Secondary patency rates were 80.1% and 75.2% at 1 and 5 years, respectively, without difference between the subgroups. The amputation rate was lower in the embolic group at 1 and 5 years (8.1% and 11.1%, respectively, p = .001). Survival was higher in the group with occluded.popliteal aneurysms at 5 years (83.3%, p = 0.004). Amputation free survival was 72.1% and 45.2% at 1 and 5 years; lower in the occluded graft/stent group at five years (37.9%, p = .007).

    Conclusion: Intra-arterial thrombolytic therapy achieves good medium and long-term clinical outcome, reducing the need of open surgical treatment in most patients.

    Keywords
    Thrombolysis, Acute limb ischaemia, Long-term outcome, Long-term follow-up, Amputation free survival, Aetiological subgroups
    National Category
    Cardiac and Cardiovascular Systems Surgery
    Identifiers
    urn:nbn:se:uu:diva-329713 (URN)10.1016/j.ejvs.2017.02.003 (DOI)000403518800018 ()28291676 (PubMedID)
    Available from: 2017-10-03 Created: 2017-10-03 Last updated: 2018-10-24Bibliographically approved
    3. Open versus endovascular revascularization in the treatment of acute lower limb ischaemia
    Open this publication in new window or tab >>Open versus endovascular revascularization in the treatment of acute lower limb ischaemia
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    2018 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 105, no 12, p. 1598-1606Article in journal (Refereed) Published
    Abstract [en]

    Background: Consensus is lacking regarding intervention for patients with acute lower limb ischaemia (ALI). The aim was to study amputation-free survival in patients treated for ALI by either primary open or endovascular revascularization.

    Methods: The Swedish Vascular Registry (Swedvasc) was combined with the Population Registry and National Patient Registry to determine follow-up on mortality and amputation rates. Revascularization techniques were compared by propensity score matching 1:1.

    Results: Of 9736 patients who underwent open surgery and 6493 who had endovascular treatment between 1994 and 2014, 3365 remained in each group after propensity score matching. Results are from the matched cohort only. Mean age of the patients was 74⋅7 years; 47⋅5 per cent were women and mean follow-up was 4⋅3 years. At 30-day follow-up, the endovascular group had better patency (83⋅0 versus 78⋅6 per cent; P < 0⋅001). Amputation rates were similar at 30 days (7⋅0 per cent in the endovascular group versus 8⋅2 per cent in the open group; P = 0⋅113) and at 1 year (13⋅8 versus 14⋅8 per cent; P = 0⋅320). The mortality rate was lower after endovascular treatment, at 30 days (6⋅7 versus 11⋅1 per cent; P < 0⋅001) and after 1 year (20⋅2 versus 28⋅6 per cent; P < 0⋅001). Accordingly, endovascular treatment had better amputation-free survival at 30 days (87⋅5 versus 82⋅1 per cent; P < 0⋅001) and 1 year (69⋅9 versus 61⋅1 per cent; P < 0⋅001). The number needed to treat to prevent one death within the rst year was 12 with an endovascular compared with an open approach. Five years after surgery, endovascular treatment still had improved survival (HR 0⋅78, 99 per cent c.i. 0⋅70 to 0⋅86) but the difference between the treatment groups occurred mainly in the rst year.

    Conclusion: Primary endovascular treatment for ALI appeared to reduce mortality compared with open surgery, without any difference in the risk of amputation.

    National Category
    Medical and Health Sciences Surgery
    Research subject
    Medical Science; Surgery
    Identifiers
    urn:nbn:se:uu:diva-363353 (URN)10.1002/bjs.10954 (DOI)000447124200007 ()
    Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-12-12Bibliographically approved
    4. Time-trends and management of acute aortic occlusion: a 21-years´ experience
    Open this publication in new window or tab >>Time-trends and management of acute aortic occlusion: a 21-years´ experience
    (English)In: Article in journal (Other academic) Submitted
    Abstract [en]

    Background: Acute aortic occlusion (AAO) is a rare and potentially catastrophic event. The aim was to study epidemiology and outcome of surgical treatment of AAO in a population-based cohort.

    Method: The Swedish nationwide vascular database (Swedvasc) was used to identify cases, and the Population Registry to study long-term survival.

    Results: During the 21-year study-period (1994-2014), 715 cases of AAO were included with a yearly incidence of 3.8 per million inhabitants. Mean age was 69.7 years, 50.5% were women and mean follow-up was 5.2 years. Most patients presented with bilateral acute limb ischemia. The aetiology for AAO was in-situ thrombosis in 64.1%, saddle embolus in 21.3% and occluded graft/stent/stentgrafts in 14.7%. The proportion of occluded grafts/stent/stentgrafts increased during the study period with a simultaneous reduction in the proportion of in-situ thrombosis.

    The most commonly used methods for revascularization were thromboembolectomy (32.0%), thrombolysis (22.4%), axillary-bifemoral bypass (18.9%) and aorto-biiliacal/bifemoral bypass (18.2%). The choice of revascularization technique depended on the aetiology of the occlusion.

    Amputation was preformed in 8.6%, and 19.9% of the patients died within 30-days after surgery. The 30-days mortality rate was lower after occluded grafts/stents/stentgrafts (9.5%) and higher after saddle embolus (30.9%, p<0.001). There was a reduction in overall 30-days mortality over time (25.0% 1994-2000 versus 15.3% 2008-2014, p=0.008). Long-term survival revealed significant differences between the subgroups, although the difference occurred early after the event (log-rank, p<0.001).

    Conclusion: Mortality after AAO is improving over time, but remains high. The proportion of AAO secondary to occluded grafts/stents/stentgrafts increased over time.

    National Category
    Medical and Health Sciences
    Research subject
    Surgery
    Identifiers
    urn:nbn:se:uu:diva-363356 (URN)
    Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-10-24Bibliographically approved
  • Public defence: 2018-12-14 09:15 Rudbecksalen, Uppsala
    Morin, Eric
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University.
    Neuropilin-1 regulation of tumor vascularization and growth2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. This thesis explores the impact of neuropilin-1 (NRP1) presentation of vascular endothelial growth factor-A (VEGF-A) to its cognate receptor, VEGFR2. NRP1 presentation of VEGF-A occurs in cis (when NRP1 and VEGFR2 are present on the same cell) or in trans (when molecules are present on adjacent cells). As shown in this thesis, the different modes of NRP1 presentation influence endothelial cell signaling and tumor angiogenesis. The overall aim with the studies has been to identify new biomarkers for cancer survival and potential therapeutic targets.

    In paper I, we explored if signaling downstream of VEGFR2 was affected by NRP1 presentation in cis compared to trans. Complex formation in trans was readily identified, however, the kinetics were delayed and prolonged, inhibiting VEGFR2 internalization and downstream signaling. Additionally, in vivo tumor studies in mice demonstrated that trans presentation of NRP1 led to early inhibition of angiogenesis and suppressed tumor initiation.

    In paper II, the presence and clinical impact of trans VEGFR2/NRP1 complexes in human cancer was investigated. We first identified gastric and pancreatic adenocarcinomas (PDAC) as candidates for further investigation. VEGFR2/NRP1 complexes were identified in both tumor types but were more prevalent in PDAC. Trans presentation of NRP1 in PDAC correlated with a reduction in several vessel parameters and tumor cell proliferation. Importantly, this study identified the presence of trans complexes as an independent marker of longer overall survival for PDAC patients.

    In paper III, we explored the impact of NRP1 presentation modes on renal cell carcinoma (RCC) patient survival. We performed in situ proximity ligation assay (PLA) and immunofluorescence staining on a RCC cohort. Tumor cell NRP1, either trans-complexed with endothelial cell-expressed VEGFR2 as detected by in situ PLA, or alternatively, detected by immunofluorescent staining, was identified as an independent predictor of increased overall survival. These data reinforce the importance of the cell type-specific expression of cancer biomarkers.

    List of papers
    1. NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation
    Open this publication in new window or tab >>NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation
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    2014 (English)In: Developmental Cell, ISSN 1534-5807, E-ISSN 1878-1551, Vol. 28, no 6, p. 633-646Article in journal (Refereed) Published
    Abstract [en]

    Neuropilin 1 (NRP1) modulates angiogenesis by binding vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. We examined the consequences when VEGFR2 and NRP1 were expressed on the same cell (cis) or on different cells (trans). In cis, VEGF induced rapid VEGFR2/NRP1 complex formation and internalization. In trans, complex formation was delayed and phosphorylation of phospholipase C gamma (PLC gamma) and extracellular regulated kinase 2 (ERK2) was prolonged, whereas ERK1 phosphorylation was reduced. Trans complex formation suppressed initiation and vascularization of NRP1-expressing mouse fibrosarcoma and melanoma. Suppression in trans required high-affinity, steady-state binding of VEGF to NRP1, which was dependent on the NRP1 C-terminal domain. Compatible with a trans effect of NRP1, quiescent vasculature in the developing retina showed continuous high NRP1 expression, whereas angiogenic sprouting occurred where NRP1 levels fluctuated between adjacent endothelial cells. Therefore, through communication in trans, NRP1 can modulate VEGFR2 signaling and suppress angiogenesis.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-224353 (URN)10.1016/j.devcel.2014.02.010 (DOI)000333765900005 ()
    Available from: 2014-05-13 Created: 2014-05-09 Last updated: 2018-10-26
    2. VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
    Open this publication in new window or tab >>VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
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    2018 (English)In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 246, no 3, p. 311-322Article in journal (Refereed) Published
    Abstract [en]

    Unstable and dysfunctional tumor vasculature promotes cancer progression and spread. Signal transduction by the pro-angiogenic vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) is modulated by VEGFA-dependent complex formation with neuropilin 1 (NRP1). NRP1 expressed on tumor cells can form VEGFR2/NRP1 trans-complexes between tumor cells and endothelial cells which arrests VEGFR2 on the endothelial surface, thus interfering with productive VEGFR2 signaling. In mouse fibrosarcoma, VEGFR2/NRP1 trans-complexes correlated with reduced tumor vessel branching and reduced tumor cell proliferation. Pancreatic ductal adenocarcinoma (PDAC) strongly expressed NRP1 on both tumor cells and endothelial cells, in contrast to other common cancer forms. Using proximity ligation assay, VEGFR2/NRP1 trans-complexes were identified in human PDAC tumor tissue, and its presence was associated with reduced tumor vessel branching, reduced tumor cell proliferation, and improved patient survival after adjusting for other known survival predictors. We conclude that VEGFR2/NRP1 trans-complex formation is an independent predictor of PDAC patient survival. 

    Place, publisher, year, edition, pages
    Wiley-Blackwell, 2018
    Keywords
    VEGF, neuropilin 1, pancreatic adenocarcinoma, trans-complex, branching
    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:uu:diva-363966 (URN)10.1002/path.5141 (DOI)30027561 (PubMedID)
    Funder
    Swedish Research Council, 2015-02375Swedish Cancer Society, CAN2016/578Knut and Alice Wallenberg Foundation, KAW 2015.0030Knut and Alice Wallenberg Foundation, KAW 2015.0275
    Available from: 2018-10-22 Created: 2018-10-22 Last updated: 2018-12-05Bibliographically approved
    3. Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma
    Open this publication in new window or tab >>Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma
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    (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827Article in journal (Other academic) Submitted
    Abstract [en]

    Background: Considerable progress in renal cell carcinoma (RCC) treatment has been made in the last decade with the introduction of drugs targeting tumor angiogenesis. However, the 5-year survival of metastatic disease is still only 10-15%. Here, we explored the prognostic significance of compartment-specific expression of Neuropilin 1 (NRP1), a co-receptor for vascular endothelial growth factor (VEGF). NRP1 expression was analyzed in RCC tumor vessels, in perivascular tumor cells and generally in the tumor cells. Moreover, complex formation between NRP1 and the main VEGF receptor, VEGFR2, was determined.

    Methods: VEGFR2/NRP1 complex formation in cis (on the same cell) and trans (between cells) configurations was determined by in situ proximity ligation assay, and NRP1 protein expression in three compartments (endothelial cells, perivascular tumor cells and general tumor cell expression) was determined by immunofluorescent staining, in a cohort of 64 advanced renal cell carcinoma patients.

    Results: VEGFR2/NRP1 trans complexes were detected in 75% of the patient samples. The presence of trans VEGFR2/NRP1 complexes or perivascular NRP1 was associated with a reduced tumor vessel density. The presence of VEGFR2/NRP1 trans complexes, perivascular NRP1 and general tumor cell NRP1 expression correlated with improved survival, however, only VEGFR2/NRP1 trans complexes and perivascular NRP1 expression remained significant in multivariable analysis.

    Conclusion: Our work shows that VEGFR2/NRP1 complexes in trans, as well as perivascular NRP1 expression, are independent markers of improved survival in advanced renal cell carcinoma.

    Keywords
    renal cell carcinoma, NRP1, VEGFR2, angiogenesis, trans complex formation
    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:uu:diva-363970 (URN)
    Available from: 2018-10-22 Created: 2018-10-22 Last updated: 2018-10-26
  • Morgan, Jessica
    et al.
    Lam, Hanh
    Delgado, jocelyn
    Luu, Justin
    Mohammadi, Sina
    Isberg, Ralph
    Wang, Helen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Auerbuch, Victoria
    An experimental pipeline for initial characterization of bacterial type III secretion system inhibitor mode of action using enteropathogenic Yersinia2018In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988Article in journal (Refereed)
    Abstract [en]

    Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with T3SS inhibitory activity have been identified, few T3SS inhibitors have been validated and mode of action determined. One issue is the lack of standardized orthogonal assays following high throughput screening. Using a training set of commercially available compounds previously shown to possess T3SS inhibitory activity, we demonstrate the utility of an experiment pipeline comprised of six distinct assays to assess the stages of type III secretion impacted: T3SS gene copy number, T3SS gene expression, T3SS basal body and needle assembly, secretion of cargo through the T3SS, and translocation of T3SS effector proteins into host cells. We used enteropathogenic Yersinia as the workhorse T3SS-expressing model organisms for this experimental pipeline, as Yersinia is sensitive to all T3SS inhibitors we tested, including those active against other T3SS-expressing pathogens. We find that this experimental pipeline is capable of rapidly distinguishing between T3SS inhibitors that interrupt the process of type III secretion at different points in T3SS assembly and function. For example, our data suggests that Compound 3, a malic diamide, blocks either activity of the assembled T3SS or alters the structure of the T3SS in a way that blocks T3SS cargo secretion but not antibody recognition of the T3SS needle. In contrast, our data predicts that Compound 4, a haloid-containing sulfonamidobenzamide, disrupts T3SS needle subunit secretion or assembly. Furthermore, we suggest that misregulation of copy number control of the pYV virulence plasmid, which encodes the Yersinia T3SS, should be considered as a possible mode of action for compounds with T3SS inhibitory activity against Yersinia.

  • Qutait, Tasnim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of English. Uppsala Univ, Uppsala, Sweden.
    "Qabbani versus Qur'an": Arabism and the Umma in Robin Yassin-Kassab's The Road from Damascus2018In: OPEN CULTURAL STUDIES, ISSN 2451-3474, Vol. 2, no 1, p. 73-83Article in journal (Refereed)
    Abstract [en]

    In The Road from Damascus (2008), Syrian-British writer Robin Yassin-Kassab's debut novel, the protagonist describes "the opposing camps of [his] childhood," as narratives of "Qabbani versus Qur'an" (56). While Sami's father idolises the pan-Arabist poet Nizar Qabbani and supports the Syrian regime despite its repressive policies, Sami's mother, disillusioned with nationalist ideology, turns instead to faith, offering her son a "different mythology" based on "the adventures of God's messengers" (53). Tracing Sami's negotiations of these seemingly opposed inherited narratives, Yassin-Kassab's novel examines the lingering impact of pan-Arabism and the alternatives offered by Islamic frameworks. While critics have previously approached this novel as part of a growing corpus of British Muslim fiction, in this essay, I focus more closely on the novel's interrogation of Arab nationalism. As I will show, Yassin-Kassab's novel unfolds as a series of ideological disillusionments that chart the protagonist's confrontation with the failure of nationalist politics. Inviting the reader to follow the protagonist's successive conversions and de-conversion from various forms of nationalism, Yassin-Kassab's representation of the polarisation between " Qabbani versus Qur'an" poses the question of how one might find alternatives beyond such restrictive dichotomies, dramatizing the inadequacies of political vision in the Arab world today.

  • Eklund, Sophia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Vargen, den trebenta hunden och Djävulen: En motivanalytisk studie kring föreställningen om varulven i svensk folktro2018Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
  • Nordström, Albin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Herbert, Roger
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Identification of the temporal control on nitrate removal rate variability in a denitrifying woodchip bioreactor2019In: Ecological Engineering: The Journal of Ecotechnology, ISSN 0925-8574, E-ISSN 1872-6992, Vol. 127, p. 88-95Article in journal (Refereed)
    Abstract [en]

    Nitrate (NO3) removal rates in a denitrifying woodchip bioreactor (DWB) removing NO3 from mine water in a subarctic climate was modeled with the purpose of determining the processes controlling variability in NO3 removal rates over time. The Eyring equation was used to define the temperature dependency, while a rate law was used to describe the NO3 concentration dependency of the NO3 removal rates. The results show that the temperature and NO3 concentration dependency of the NO3 removal rates changes over time in the DWB due to the preferential selection of conceptualized NO3 - reducing bacteria favoring low temperatures, with the mean temperature optimum of the NO3 reducing consortium decreasing from 24.2 °C to 16.0 °C following the first year of DWB operations. It is suggested that the selection of the low temperature NO3 reducers in the DWB represented an increased dependence on cross-feeding between a fermentative community, producing the reactive organic carbon substrate, and a denitrifying community, consuming the organic carbon substrate, with the temporal variability in NO3 removal rates being controlled by the stabilization of the microbial community structure. It is also suggested that the life expectancy of DWBs is more related to the stability of the cross-feeding between the fermenting microbial community and the denitrifying microbial community, than to the total carbon content.

  • Hägg, Linus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics. KTH, Avdelningen för fusionsplasmafysik.
    Plasma diagnostics for particle confinement studies in magnetic fusion devices2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates the performance and improves a double color interferometer setup, absolutely calibrates a line radiation Balmer H-alpha measurement setup, and uses measurements from both setups to estimate the particle confinement time of a plasma.

    The double colour interferometer at the magnetic confinement plasma device EXTRAP T2R measures the line integrated electron density of the plasma. Electron density is an important parameter in fusion plasma diagnostics but the interferometer at EXTRAP T2R have had several problems. The interferometer setup was changed as follows: A piezo phase shifter was added, the beam expander was adjusted with the help of thermal image plates, and the electronics setup was rewired to remove interferences.

    The setup for Balmer H-alpha line radiation measurements was calibrated and characterized. The particle confinement time was estimated using Abel inversion to produce radial profiles of electron density, electron temperature and H-alpha irradiance.

    The interferometer upgrades did not solve all the problems, but the electron density measurements are now reliable up to around 10 – 20 ms. Since the interferometer only has one channel the electron density profile could not be determined reliably. However, the particle confinement time was estimated for two possible electron density profiles and the results agree with previous studies.

  • Forssell, Emil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law. 199110154011.
    Att avtala om rättskraft i dispositiva tvistemål: Särskilt om processuella avtal och negativ rättskraft2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Enligt 17:11 Rättegångsbalken (1942:740) gäller att en dom har rättskraft, vilket bland annat medför att samma sak inte kan tas upp och prövas av rätten igen (res judicata). Givet den negativa rättskraftens betydelsefulla rättsliga verkan och dess breda prekluderande effekt, ställer jag mig frågan om det är möjligt för parterna i dispositiva tvistemål att avtala om rättskraftens verkningar.

  • Entenza, Robin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Initial Coin Offerings och EUs värdepappersmarknadsreglering2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Westlund, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    The development of the right to privacy under the ECHR: A study on the effect of Article 8 on third parties2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Westerlund, Zackarias
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Skyddet för bostaden: Hur skyddas fysiska personer mot att bli av med sitt boende?2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Public defence: 2018-12-14 13:00 Auditorium minus, Uppsala
    Axfors, Cathrine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Anxious personality traits in pregnant women: Associations with postpartum depression, delivery complications and health care use2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Anxious personality traits, including those encompassed by negative emotionality (neuroticism) and the tendency to worry about close relationships (attachment anxiety) during pregnancy were the focus of this thesis. The overall aim was to examine perinatal correlates of these characteris-tics in terms of psychiatric and obstetric health as well as antenatal care (ANC).

    Papers I-II were part of a large population-based project on pregnant women in Uppsala in 2009-2012 (n=2160). Papers III-IV adjoined participants from several projects in 2005-2011, on oral contraceptive use, infertility, induced abortion, premenstrual mood disorder, and perina-tal depression (n=2819). The participants reported on the Swedish universities Scales of Per-sonality for neuroticism (papers II-IV) and the Attachment Style Questionnaire (ASQ) for attachment anxiety (papers I-II). The participants also answered the Edinburgh Postnatal De-pression Scale on depressive symptoms (paper II). In paper III, information on obstetric com-plications for primiparous women with singleton pregnancies (n=1969) was extracted from Swedish national health registers. In paper IV, ANC use was derived from medical records of obstetric low-risk women residing in Uppsala (n=1052).

    The ASQ had similar psychometric properties in pregnant women (n=1631) as in previous reports (paper I). In non-depressed pregnant women (n=1431), the combination of neuroticism and attachment anxiety was the best risk indicator of postpartum depressive symptoms (paper II). Whereas high neuroticism was not related to obstetric complications (paper III), it was associated with higher use of ANC (paper IV).

    Summarized, this thesis illustrates how anxious personality traits may predispose for post-partum depression and higher use of ANC in the absence of obstetric complications. Future development of these findings should be to evaluate individual and societal benefits of a greater emphasis on psychological support in ANC.

    List of papers
    1. Psychometric properties of the attachment style questionnaire in Swedish pregnant women: short and full versions
    Open this publication in new window or tab >>Psychometric properties of the attachment style questionnaire in Swedish pregnant women: short and full versions
    2017 (English)In: Journal of Reproductive and Infant Psychology, ISSN 0264-6838, E-ISSN 1469-672X, Vol. 35, no 5, p. 450-461Article in journal (Refereed) Published
    Abstract [en]

    Objectives: (i) To evaluate the reliability and factor structure of the Attachment Style Questionnaire – Short Form (ASQ-SF) for use in pregnant women and (ii) to compare the reliability and factor structure of the short- and full version-ASQ among pregnant women. Background: Adult attachment insecurity is currently included as a major risk factor in studies of perinatal health. None of the self-report measures with a Swedish translation have been psychometrically evaluated in a pregnant cohort.

    Methods: A population-based cohort of 1631 pregnant women answered the ASQ in late pregnancy. Internal consistency (item- subscale correlations, Cronbach’s α, and α if item deleted) was evaluated for the seven available subscales. Con rmatory factor analysis (CFA) was run to examine the factor structure of the short form compared with the full-version. Test–retest correlations were assessed in a subgroup (n = 48).

    Results: All mean item-subscale correlations for the ASQ-SF were > 0.30. Cronbach’s α’s for ASQ-SF dimensions were as follows: Avoidance (0.87); Anxiety (0.89); Discomfort with Closeness (0.85); Relationships as Secondary (0.54); Con dence (0.83); Need for Approval (0.76); and Preoccupation with Relationships (0.77). No item removal substantively increased subscale α’s. The CFA demonstrated better model t for the ASQ-SF than for the full-version ASQ, while other reliability measures were similar. Test–retest correlations ranged from 0.65 to 0.84.

    Conclusion: The ASQ-SF showed similar psychometric properties in pregnant women as in the general population and had good reliability, but the optimal factor structure needs to be studied further. Results support the usage of the ASQ-SF in pregnant cohorts. 

    Place, publisher, year, edition, pages
    Routledge, 2017
    Keywords
    adult attachment, attachment style questionnaire, reliability, pregnancy
    National Category
    Clinical Medicine
    Research subject
    Psychiatry
    Identifiers
    urn:nbn:se:uu:diva-342268 (URN)10.1080/02646838.2017.1342786 (DOI)000416753300003 ()
    Funder
    Swedish Research Council, 521-2013-2339
    Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-10-24Bibliographically approved
    2. Adult attachment's unique contribution in the prediction of postpartum depressive symptoms, beyond personality traits
    Open this publication in new window or tab >>Adult attachment's unique contribution in the prediction of postpartum depressive symptoms, beyond personality traits
    2017 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 222, p. 177-184Article in journal (Refereed) Published
    Abstract [en]

    Background:

    Personality traits such as neuroticism can help identify pregnant women at risk of postpartum depressive symptoms (PPDS). However, it is unclear whether attachment style could have an additional contribution to this risk elevation. This study aimed to examine the overlap of adult attachment insecurity and neuroticism/trait anxiety as PPDS predictors, taking into account baseline depressive symptoms.

    Methods:

    A Swedish population-based sample of pregnant women reported on adult attachment and either neuroticism (n = 1063) or trait anxiety (n = 555). Depressive symptoms were assessed at baseline, and at six weeks and six months postpartum. Correlations between attachment and neuroticism/trait anxiety were calculated. Generalized linear models of PPDS tested the effect of attachment anxiety and avoidance, adjusting for neuroticism/trait anxiety and baseline depression. Logistic regression models with combined high attachment anxiety and-neuroticism/trait anxiety visualized their value as risk factors beyond antenatal depression.

    Results:

    Attachment and neuroticism/trait anxiety were highly correlated (r = .55.77). Attachment anxiety exerted a partially independent effect on PPDS at six weeks (p < .05) and at six months (p < .05) adjusting for neuroticism. Among antenatally non-depressed, combined high attachment anxiety and high neuroticism or trait anxiety was predictive of PPDS at both assessment points. Limitations: Low acceptance rate, exclusive use of self-reports.

    Conclusions:

    Beyond personality, attachment anxiety had a small independent effect on the risk of PPDS. Combining items of adult attachment and neuroticism/trait anxiety could prove useful in antenatal screening for high risk of PPDS.

    Keywords
    Adult attachment, Neuroticism, Trait anxiety, Personality, Pregnancy, Postpartum depression
    National Category
    Psychiatry
    Identifiers
    urn:nbn:se:uu:diva-333735 (URN)10.1016/j.jad.2017.07.005 (DOI)000407657100027 ()28709025 (PubMedID)
    Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2018-10-24Bibliographically approved
    3. Neuroticism is not independently associated with adverse obstetric or neonatal outcomes: An observational study
    Open this publication in new window or tab >>Neuroticism is not independently associated with adverse obstetric or neonatal outcomes: An observational study
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    National Category
    Psychiatry Obstetrics, Gynecology and Reproductive Medicine
    Research subject
    Psychiatry; Obstetrics and Gynaecology
    Identifiers
    urn:nbn:se:uu:diva-361592 (URN)
    Available from: 2018-09-25 Created: 2018-09-25 Last updated: 2018-10-24
    4. Neuroticism is associated with higher antenatal care utilization in obstetric low-risk women
    Open this publication in new window or tab >>Neuroticism is associated with higher antenatal care utilization in obstetric low-risk women
    Show others...
    (English)In: Article in journal (Refereed) Submitted
    Place, publisher, year, edition, pages
    Uppsala:
    National Category
    Obstetrics, Gynecology and Reproductive Medicine
    Research subject
    Obstetrics and Gynaecology
    Identifiers
    urn:nbn:se:uu:diva-364260 (URN)
    Available from: 2018-10-24 Created: 2018-10-24 Last updated: 2018-10-24
  • Storfors, Anton
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Signals and Systems Group.
    Automatic control of a model elevator based on NI LabVIEW and myRIO2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This project aims to use the myRIO embedded device with programming development software, LabVIEW, for the education of automatic control in association with the course Control Engineering (Reglerteknik) in Uppsala University. 

    The myRIO is a portable reconfigurable I/O (RIO) device developed by National Instruments for students to use for designing control, signal processing, robotics, and mechatronics systems. It contains a Xilinx FPGA and a dual-core ARM Cortex-A9 micro-controller that can be programmed with LabVIEW (Laboratory Virtual Instrument Engineering Workbench). 

    The control system that the project is concerned with is to control a model elevator which, available for the project, is a cabinet driven by a DC motor up and down along two steel poles. It is a representative control system, containing all possible components of a feedback control system, i.e., controlled process, actuator, controller, sensor. The elevator (the controlled process) has three floors with pre-specified heights. The height is determined by an ultrasonic sensor (for feedback). The motor (the actuator) is controlled by a PID (proportional-integral-derivative) controller. 

    The specifications for the control system implemented are given beforehand, in particular, the parameters related to system performance such as stability, responsiveness and accuracy (or residual error), as well as real time display of operating information. 

    The motor driver (a H-bridge circuit) for the motor and the circuit for the information have been built. The myRIO is used to implement the PID controller, handle the set point specifying floor number, manage the sensor measurements. The whole elevator control system has been implemented and tested. The test results show that the control system works well and fulfills the given specifications. Further work on improvements for the project is suggested. The myRIO is shown to be an excellent device well suited for the education of control engineering.

  • Public defence: 2018-12-14 13:15 Häggsalen, Ångströmlaboratoriet, Uppsala
    Phuyal, Dibya
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    An X-ray Spectroscopic Study of Perovskites Oxides and Halides for Emerging Devices2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis investigates the electronic structures on several perovskite oxide and halide materials with a focus on light harvesting applications. The systematic study of the electronic properties of the transition metal oxides and post-transition metal halides is a key point if one is to understand their properties. The element and site selective nature of several x-ray based spectroscopic techniques are given special emphasis in order to obtain a complete picture of the electronic properties of the compounds in question. Much of the experimental studies are accompanied by ab initio calculations that corroborate with our experimental results.

    In the oxide portion of this work, a new class of metallic oxides based on doping of an antiferromagnetic LaFeO3 was synthesized and systematically studied with x-ray absorption, x-ray emission, and photoemission spectroscopies. The compound’s electronic structure is complex, having itinerant as well as localized components that give rise to a unique physical state where antiferromagnetism, metallicity and charge-disproportionation coexist. Our resonant photoemission results establish that the Fe states in both magnetically ordered oxides show insulting properties, while the Mo states provide an itinerant band crossing the Fermi level. An excitation energy-dependent RIXS investigation on LaFe1-xMoxO3 and the double perovskite Sr2FeMoO6 revealed a double peak structure located in proximity to the elastic peak that is identified to purely d-d excitations, attributed to the strongly correlated nature of these transition metal compounds.

    The growth of high-quality thin film ferroelectric based on BaTiO3 grown epitaxially by means of pulsed laser deposition were investigated. We systematically reduce the band gap of the ferroelectric thin film while retaining its polarization at ambient conditions in spite of the aliovalent doping. The electronic structure is studied by several x-ray techniques that show how the ferroelectricity persists as well as the effective reduction of the band gap through hybridized states.

    In the post-transition metal halides, the valence and conduction bands were mapped using x-ray absorption, emission, and photoemission spectroscopies. The spectroscopic results identify the constituent states that form the valence band as well as the band energy positions, which is an imperative parameter in optoelectronic devices. In addition, x-ray based spectroscopy was used to demonstrate the stereochemical activity of lone-pair states (5s2 and 6s2) for several different halide compounds and their influence on the chemical, structural, and electronic properties of the material. Nanostructured halide perovskites are also explored. The position of iodine p states and valence band states in reduced dimensional lead-based compounds were examined, as their states are found to be confined in one crystallographic direction in contrast to their three-dimensional counterpart. This information highlights the interesting material properties and their use in current third generation solar cell research.

    List of papers
    1. Electronic structure of the charge disproportionate and metallicity in LaFe1-xMoxO3 studied by resonant x-ray spectroscopies
    Open this publication in new window or tab >>Electronic structure of the charge disproportionate and metallicity in LaFe1-xMoxO3 studied by resonant x-ray spectroscopies
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    A metal-insulator transition and its intriguing properties were recently reported based on doping of the antiferromagnetic insulator LaFeO3. Through doping at the B site by Mo to the insulating perovskite LaFeO3 exhibits a coexistence of an antiferromagnetic ordering with room-temperature metallicity at higher doping levels, an unusual ground state for an oxide perovskite. Replacing Fe by Mo in the Fe-O6 octahedra enhances the separation of the two 2 Fe-O bonds relative to the orthorhombic LaFeO3, largely retaining the centrosymmetric character of the Fe sites, as confirmed through extended x-ray absorption fine structure. Mo ions appear to be homogeneously doped, with average valency of both metal sites monotonically decreasing with increasing Mo concentration. Resonant photoemission was recorded for both Fe and Mo to obtain element specific spectral information on the projected 3d and 4d partial density of states. The data shows gradual increase of spectral weight at the Fermi level that is attributed to Mo d states, while the Fe d states primarily reside at higher binding energy in the valence band, with significant hybridization with O 2p states. The RIXS spectra show strong electron correlation effects from d-d inelastic features and broad charge-transfer excitations for x = 0.2 where the compound becomes metallic. This is in contrast to the insulating parent LaFeO3 compound and insulating samples with lower Mo content. The coexistence of both bound and continuum excitations observed in the RIXS spectra provides strong evidence for charge disproportionation with features that are linked to the disproportionate Fe sites.

    National Category
    Condensed Matter Physics
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364367 (URN)
    Funder
    Knut and Alice Wallenberg Foundation, 2012.0031Swedish Energy Agency, P45349-1Swedish Research Council, 2014-6019Carl Tryggers foundation , CTS-17:376
    Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-10-26
    2. Valence electronic structure of the double perovskite Sr2FeMoO6 through resonant x-ray spectroscopies
    Open this publication in new window or tab >>Valence electronic structure of the double perovskite Sr2FeMoO6 through resonant x-ray spectroscopies
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Resonant x-ray spectroscopies were used to investigate the double perovskite Sr2FeMoO6 (SFMO) in order to identify the compounds valence electronic structure known for its half-metallicity and ferrimagnetism above room temperature. A comprehensive resonant photoelectron spectroscopy (RPES) and resonant inelastic x-ray scattering (RIXS) study was carried out to acquire a more detailed understanding and interpretation of the valence band electronic structure and hybridization between Fe and Mo d bands. The RPES spectrum clearly show enhancement of Mo d states at the Fermi level that are partly responsible for the metallic behavior. The RPES data at the Fe L3 edge shows strong hybridization with O 2p states as well hybridization with Mo d states. At the same time, characteristic d-d excitations are observed in the RIXS spectra at the Fe L edge indicative of Fe d states of more localized character. Although there are many valid definitions to the valency of the Fe and Mo ions and magnetic moments, the total electronic structure represented through element-resolved x-ray spectroscopies studies distinctly identifies the electronic states that results in its established correlated behavior and half-metallicity.

    National Category
    Condensed Matter Physics
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364368 (URN)
    Funder
    Carl Tryggers foundation , CTS-17:376Swedish Energy Agency, P43549-1Swedish Research Council, 2016-4524Knut and Alice Wallenberg Foundation, 2012.0031Swedish Foundation for Strategic Research , 15-0130
    Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-10-26
    3. The origin of low bandgap and ferroelectricity of a co-doped BaTiO3
    Open this publication in new window or tab >>The origin of low bandgap and ferroelectricity of a co-doped BaTiO3
    Show others...
    2018 (English)In: Europhysics letters, ISSN 0295-5075, E-ISSN 1286-4854Article in journal (Refereed) Accepted
    Abstract [en]

    We recently demonstrated the lowest bandgap bulk ferroelectric material, BaTi1-x(Mn1/2Nb1/2)xO3, a promising candidate material for visible light absorption in opto- electronic devices. Using a combination of x-ray spectroscopies and density functional theory (DFT) calculations, we here elucidate this compound’s electronic structure and the modifications induced by Mn doping. In particular, we are able to rationalize how this compound retains its ferroelectricity even through a significant reduction of the optical gap upon Mn doping. The local electronic structure and atomic coordination are investigated using x-ray absorption at the Ti K, Mn K, and O K edges, which suggests only small distortions to the parent tetragonal ferroelectric system, BaTiO3, thereby providing a clue to the substantial retention of ferroelectricity in spite of doping. Features at the Ti K edge, which are sensitive to local symmetry and an indication of Ti off-centering within the Ti-O6 octahedra, show modest changes with doping and strongly corroborates with our measured polarization values. Resonant photoelectron spectroscopy results suggest the origin of the reduction of the bandgap in terms of newly created Mn d bands that hybridize with O 2p states. X-ray absorption spectra at the O K-edge provide evidence for new states below the conduction band of the parent compound, illustrating additional contributions facilitating bandgap reduction.

    National Category
    Condensed Matter Physics
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364369 (URN)
    Funder
    Swedish Foundation for Strategic Research , 15-0130Knut and Alice Wallenberg Foundation, 2012.0031Swedish Energy Agency, P43549-1Swedish Energy Agency, P43294-1Swedish Research Council, 2014-7019Swedish Research Council, 2016-4524
    Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-10-26
    4. Ferroelectric properties of doped BaTiO3 thin film by pulsed laser deposition
    Open this publication in new window or tab >>Ferroelectric properties of doped BaTiO3 thin film by pulsed laser deposition
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    BaTiO3 thin films co-doped at the Ti site with Mn and Nb were grown on 0.5% Nb-doped (001) oriented SrTiO3 substrates by pulsed laser deposition. The films show single-phase tetragonal structure, growing epitaxially with a smooth interface to the substrate. Using piezoforce microscopy, we find that both doped and undoped films exhibit good ferroelectric response. The piezoelectric domain switching in the films was confirmed by measuring local hysteresis of the polarization at several different areas across the thin films, demonstrating a switchable ferroelectric state for these films. The doping of the BaTiO3 also reduces the bandgap of the material from 3.18 eV for BaTiO3 to nearly 2.7 eV for the 7.5% doped sample, potentially making the films effective light-harvesters in the visible spectrum. The results demonstrate co-doping as an effective strategy for bandgap engineering and a guide for the realization of visible-light applications of related thin film systems.

    National Category
    Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364370 (URN)
    Funder
    Swedish Research Council, 2014-6019Swedish Research Council, 2016-4524Swedish Energy Agency, P43549-1Knut and Alice Wallenberg Foundation, 2012.0031Swedish Foundation for Strategic Research , 15-0130
    Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-10-26
    5. Impact of synthetic routes on the structural and physical properties of butyl-1,4-diammonium lead iodide semiconductors
    Open this publication in new window or tab >>Impact of synthetic routes on the structural and physical properties of butyl-1,4-diammonium lead iodide semiconductors
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    2017 (English)In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 5, no 23, p. 11730-11738Article in journal (Refereed) Published
    Abstract [en]

    We report the significant role of synthetic routes and the importance of solvents in the synthesis of organic-inorganic lead iodide materials. Through one route, the intercalation of dimethylformamide in the crystal structure was observed leading to a one-dimensional (1D) [NH3(CH2)(4)NH3]Pb2I6 structure of the product. This product was compared with the two-dimensional (2D) [NH3(CH2)(4)NH3]PbI4 recovered from aqueous solvent based synthesis with the same precursors. UV-visible absorption spectroscopy showed a red-shift of 0.1 eV for the band gap of the 1D network in relation to the 2D system. This shift primarily originates from a shift in the valence band edge as determined from photoelectron-and X-ray spectroscopy results. These findings also suggest the iodide 5p orbital as the principal component in the density of states in the valence band edge. Single crystal data show a change in the local coordination around iodide, while in both materials, lead atoms are surrounded by iodide atoms in octahedral units. The conductivity of the one-dimensional material ([NH3(CH2)(4)NH3]Pb2I6) was 50% of the two-d(i)mensional material ([NH3(CH2)(4)NH3]PbI4). The fabricated solar cells reflect these changes in the chemical and electronic structure of both materials, although the total light conversion efficiencies of solar cells based on both products were similar.

    Place, publisher, year, edition, pages
    ROYAL SOC CHEMISTRY, 2017
    National Category
    Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-329653 (URN)10.1039/c6ta10123b (DOI)000403228200030 ()
    Funder
    StandUpSwedish Energy AgencySwedish Research CouncilKnut and Alice Wallenberg Foundation
    Available from: 2017-09-20 Created: 2017-09-20 Last updated: 2018-10-26Bibliographically approved
    6. Electronic Structure of Two-Dimensional Lead(II) Iodide Perovskites: An Experimental and Theoretical Study
    Open this publication in new window or tab >>Electronic Structure of Two-Dimensional Lead(II) Iodide Perovskites: An Experimental and Theoretical Study
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    2018 (English)In: Chemistry of Materials, ISSN 0897-4756, E-ISSN 1520-5002, Vol. 30, no 15, p. 4959-4967Article in journal (Refereed) Published
    Abstract [en]

    Layered two-dimensional (2D) hybrid organic-inorganic perovskites (HOP) are promising materials for light-harvesting applications because of their chemical stability, wide flexibility in composition and dimensionality, and increases in photovoltaic power conversion efficiencies. Three 2D lead iodide perovskites were studied through various X-ray spectroscopic techniques to derive detailed electronic structures and band energetics profiles at a titania interface. Core-level and valence band photoelectron spectra of HOP were analyzed to resolve the electronic structure changes due to the reduced dimensionality of inorganic layers. The results show orbital narrowing when comparing the HOP, the layered precursor PbI2, and the conventional 3D (CH3NH3)PbI3 such that different localizations of band edge states and narrow band states are unambiguously due to the decrease in dimensionality of the layered HOPs. Support from density functional theory calculations provide further details on the interaction and band gap variations of the electronic structure. We observed an interlayer distance dependent dispersion in the near band edge electronic states. The results show how tuning the interlayer distance between the inorganic layers affects the electronic properties and provides important design principles for control of the interlayer charge transport properties, such as the change in effective charge masses as a function of the organic cation length. The results of these findings can be used to tune layered materials for optimal functionality and new applications.

    National Category
    Condensed Matter Physics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-361922 (URN)10.1021/acs.chemmater.8b00909 (DOI)000442186500014 ()
    Funder
    StandUpSwedish Energy AgencySwedish Research CouncilKnut and Alice Wallenberg Foundation
    Note

    De två första författarna delar förstaförfattarskapet.

    Available from: 2018-09-27 Created: 2018-09-27 Last updated: 2018-11-02Bibliographically approved
    7. The electronic structure and band interface of cesium bismuth iodide on a titania heterostructure using hard X-ray spectroscopy
    Open this publication in new window or tab >>The electronic structure and band interface of cesium bismuth iodide on a titania heterostructure using hard X-ray spectroscopy
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    2018 (English)In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 6, no 20, p. 9498-9505Article in journal (Refereed) Published
    Abstract [en]

    Bismuth halide compounds as a non-toxic alternative are increasingly investigated because of their potential in optoelectronic devices and their rich structural chemistry. Hard X-ray spectroscopy was applied to the ternary bismuth halide Cs3Bi2I9 and its related precursors BiI3 and CsI to understand its electronic structure at an atomic level. We specifically investigated the core levels and valence band using X-ray photoemission spectroscopy (PES), high-resolution X-ray absorption (HERFD-XAS), and resonant inelastic X-ray scattering (RIXS) to get insight into the chemistry and the band edge properties of the two bismuth compounds. Using these element specific X-ray techniques, our experimental electronic structures show that the primary differences between the two bismuth samples are the position of the iodine states in the valence and conduction bands and the degree of hybridization with bismuth lone pair (6s(2)) states. The crystal structure of the two layered quasi-perovskite compounds plays a minor role in modifying the overall electronic structure, with variations in bismuth lone pair states and iodine band edge states. Density Functional Theory (DFT) calculations are used to compare with experimental data. The results demonstrate the effectiveness of hard X-ray spectroscopies to identify element specific bulk electronic structures and their use in optoelectronic devices.

    National Category
    Materials Chemistry Physical Chemistry
    Identifiers
    urn:nbn:se:uu:diva-357561 (URN)10.1039/c8ta00947c (DOI)000433427300020 ()
    Funder
    Swedish Research Council, 2014-6019Swedish Research Council, 2016-4524Swedish Energy Agency, P43549-1Swedish Foundation for Strategic Research , 15-0130Wallenberg Foundations, 2012.0031StandUp
    Available from: 2018-08-20 Created: 2018-08-20 Last updated: 2018-10-26Bibliographically approved
    8. An effective approach of vapour assisted morphological tailoring for reducing metal defect sites in lead-free, (CH3NH3)(3)Bi2I9 bismuth-based perovskite solar cells for improved performance and long-term stability
    Open this publication in new window or tab >>An effective approach of vapour assisted morphological tailoring for reducing metal defect sites in lead-free, (CH3NH3)(3)Bi2I9 bismuth-based perovskite solar cells for improved performance and long-term stability
    Show others...
    2018 (English)In: Nano Energy, ISSN 2211-2855, E-ISSN 2211-3282, Vol. 49, p. 614-624Article in journal (Refereed) Published
    Abstract [en]

    We present a controlled, stepwise formation of methylammonium bismuth iodide (CH3NH3)(3)Bi2I9 perovskite films prepared via the vapour assisted solution process (VASP) by exposing BiI3 films to CH3NH3I (MAI) vapours for different reaction times, (CH3NH3)(3)Bi2I9 semiconductor films with tunable optoelectronic properties are obtained. Solar cells prepared on mesoporous TiO2 substrates yielded hysteresis-free efficiencies upto 3.17% with good reproducibility. The good performance is attributed mainly to the homogeneous surface coverage, improved stoichiometry, reduced metallic content in the bulk, and desired optoelectronic properties of the absorbing material. In addition, solar cells prepared using pure BiI3 films without MAI exposure achieved a power conversion efficiency of 0.34%. The non-encapsulated (CH3NH3)(3)Bi2I9 devices were found to be stable for as long as 60 days with only 0.1% drop in efficiency. This controlled formation of (CH3NH3)(3)Bi2I9 perovskite films highlights the benefit of the VASP technique to optimize material stoichiometry, morphology, solar cell performance, and long-term durability.

    Place, publisher, year, edition, pages
    ELSEVIER SCIENCE BV, 2018
    Keywords
    Vapour assisted solution process (VASP), Lead free perovskite, (CH3NH3)(3)Bi2I9, Morphological tailoring, High resolution X-ray photoelectron (HAXPES) spectroscopy
    National Category
    Materials Chemistry Condensed Matter Physics Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-358277 (URN)10.1016/j.nanoen.2018.05.003 (DOI)000434829500071 ()
    Funder
    Swedish Research CouncilEU, Horizon 2020, 663830
    Available from: 2018-08-27 Created: 2018-08-27 Last updated: 2018-10-26Bibliographically approved
    9. Inorganic CsPbI3 Perovskite Coating on PbS Quantum Dot for Highly Efficient and Stable Infrared Light Converting Solar Cells
    Open this publication in new window or tab >>Inorganic CsPbI3 Perovskite Coating on PbS Quantum Dot for Highly Efficient and Stable Infrared Light Converting Solar Cells
    Show others...
    2018 (English)In: Advanced Energy Materials, ISSN 1614-6832, Vol. 8, no 6, article id 1702049Article in journal (Refereed) Published
    Abstract [en]

    Solution-processed colloidal quantum dot (CQD) solar cells harvesting the infrared part of the solar spectrum are especially interesting for future use in semitransparent windows or multilayer solar cells. To improve the device power conversion efficiency (PCE) and stability of the solar cells, surface passivation of the quantum dots is vital in the research of CQD solar cells. Herein, inorganic CsPbI3 perovskite (CsPbI3-P) coating on PbS CQDs with a low-temperature, solution-processed approach is reported. The PbS CQD solar cell with CsPbI3-P coating gives a high PCE of 10.5% and exhibits remarkable stability both under long-term constant illumination and storage under ambient conditions. Detailed characterization and analysis reveal improved passivation of the PbS CQDs with the CsPbI3-P coating, and the results suggest that the lattice coherence between CsPbI3-P and PbS results in epitaxial induced growth of the CsPbI3-P coating. The improved passivation significantly diminishes the sub-bandgap trap-state assisted recombination, leading to improved charge collection and therefore higher photovoltaic performance. This work therefore provides important insight to improve the CQD passivation by coating with an inorganic perovskite ligand for photovoltaics or other optoelectronic applications.

    Place, publisher, year, edition, pages
    WILEY-V C H VERLAG GMBH, 2018
    Keywords
    charge recombination, inorganic perovskite, quantum dots, solar cells, surface passivation
    National Category
    Physical Chemistry Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-348982 (URN)10.1002/aenm.201702049 (DOI)000426152400017 ()
    Funder
    Swedish Energy AgencySwedish Research CouncilSwedish Research Council Formas
    Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-10-26Bibliographically approved
    10. Doping induced site-selective Mott insulating phase in LaFeO3
    Open this publication in new window or tab >>Doping induced site-selective Mott insulating phase in LaFeO3
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Tailoring transport properties of strongly correlated electron systems in a controlled fashion counts among the dreams of materials scientists. In copper oxides, vary- ing the carrier concentration is a tool to obtain high- temperature superconducting phases. In manganites, dop- ing results in exotic physics such as insulator-metal tran- sitions (IMT), colossal magnetoresistance (CMR), orbital- or charge-ordered (CO) or charge-disproportionate (CD) states. In most oxides, antiferromagnetic order and CD phase is asssociated with insulating behavior. Here we re- port the realization of a unique physical state that can be induced by Mo doping in LaFeO3: the resulting metallic state is a site-selective Mott insulator where itinerant elec- trons evolving on low-energy Mo states coexist with local- ized carriers on the Fe sites. In addition, a local breathing- type lattice distortion induces charge disproportionation on the latter, without destroying the antiferromagnetic order. A state, combining antiferromangetism, metallic- ity and CD phenomena is rather rare in oxides and have utmost significance for future antiferromagnetic memory devices.

    National Category
    Condensed Matter Physics
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-364365 (URN)
    Funder
    Swedish Research Council, 2014-6019Swedish Energy Agency, P43549-1Knut and Alice Wallenberg Foundation, 2012.0031
    Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-11-01
  • Public defence: 2018-12-14 10:15 the Humanities Theatre, Uppsala
    Nilsson Jobs, Elisabeth
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Recognizing Disability and Ability in Young Autistic Children2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Autism Spectrum Disorder (ASD) is characterized by impairments, or disabilities, in social communication and interaction (SCI), and restricted and repetitive behaviors (RRBs), but is also associated with enhanced abilities. Early identification of disability in ASD has been a primary focus in clinical practice, while abilities associated with ASD have neither been recognized nor assessed. The overarching purpose of this thesis was to improve early recognition of both disability and ability in young autistic children. Three studies were conducted in a largely overlapping sample of 3-year-old high-risk-for-ASD siblings, either with or without ASD, and low-risk-for-ASD siblings. Study I and II focused on the value of preschool staff as informants in early identification of autistic symptoms, while Study III investigated potential strengths in visual ability in autistic children. Study I investigated how accurately parents and preschool staff rated autistic symptoms in relation to diagnoses and clinical assessment of autistic symptoms. Results showed that ratings by preschool staff were more accurate than parent ratings at differentiating the ASD group from the two other groups, and more closely associated with clinical autistic symptoms. Study II focused on preschool staff’s ratings of social communication and interaction (SCI) and restricted and repetitive behaviors (RRBs). Results showed that ratings of SCI were more accurate than RRBs in differentiating the ASD group from the two other groups, and only the SCI ratings correlated with clinical assessment of social impairment. Study III investigated specific aspects of visual ability with five visual tasks. Similar performance on visual ability was found among groups, except for the Hidden Pictures (HP) task. The children with ASD had superior performance on HP compared with the other two groups. Results of Study I and II suggest that preschool staff report on autistic symptoms may complement parent report in diagnostic assessment of ASD, although their report on RRBs should be interpreted with caution. The results of Study III indicate that enhanced visual ability can be identified in autistic children already at age three. Overall, this thesis suggests that information from preschool staff and assessment of visual ability can contribute to the early recognition of disability and ability in young children with ASD.

    List of papers
    1. Local and Global Visual Processing in 3-year olds With and Without Autism
    Open this publication in new window or tab >>Local and Global Visual Processing in 3-year olds With and Without Autism
    2018 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432, Vol. 48, no 6, p. 2249-2257Article in journal (Refereed) Published
    Abstract [en]

    Research on visual local and global perception in autism spectrum disorder (ASD) is incomplete in young children. We investigated 35 three-year-old siblings of children with ASD, either diagnosed (n =12) or not diagnosed (n = 23) with ASD as well as 14 controls with typical development and with no family history of ASD. Data from the local tasks Children´s Embedded Figures Test, Hidden Pictures, Figure-Ground and the global tasks Closure and Fragmented Picture Test were collected. Enhanced performance on the local task Hidden Pictures differentiated children with ASD from the other groups. Implications of these results are discussed.  

    Keywords
    Autism, Neurodevelopmental disorder, Cognition, Visual perception, Local processing, Child development
    National Category
    Psychology Neurosciences
    Identifiers
    urn:nbn:se:uu:diva-338729 (URN)10.1007/s10803-018-3470-8 (DOI)000431955400035 ()29411217 (PubMedID)
    Funder
    EU, FP7, Seventh Framework ProgrammeSwedish Research CouncilSwedish Research Council FormasVINNOVA
    Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-10-24Bibliographically approved
    2. Spotting Signs of Autism in 3-Year-Olds: Comparing Information from Parents and Preschool Staff
    Open this publication in new window or tab >>Spotting Signs of Autism in 3-Year-Olds: Comparing Information from Parents and Preschool Staff
    2018 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432Article in journal (Other academic) Published
    Keywords
    Autism Spectrum Disorder; Early Development; Rating Scales
    National Category
    Social Sciences
    Research subject
    Psychology
    Identifiers
    urn:nbn:se:uu:diva-364104 (URN)
    Note

    Preschool informants may provide valuable information about symptoms of autism spectrum disorder (ASD) in young children. We compared the diagnostic accuracy of ratings by preschool staff with those by parents of 3-year-old children using the Achenbach System of Empirically Based Assessment (ASEBA) Preschool Forms. The sample consisted of 32 children at familial risk for ASD without diagnosis, 10 children at risk for ASD with diagnosis, and 14 low-risk typically developing controls. Preschool staff ratings were more accurate than parent ratings at differentiating children with and without ASD, and more closely associated with clinician-rated symptoms. These results point to the value of information from preschool informants in early detection and diagnostic assessments.

    Available from: 2018-10-23 Created: 2018-10-23 Last updated: 2018-11-28
    3. Preschool Staff Spot Social Communication Difficulties, but Not Restricted and Repetitive Behaviors in Young Autistic Children
    Open this publication in new window or tab >>Preschool Staff Spot Social Communication Difficulties, but Not Restricted and Repetitive Behaviors in Young Autistic Children
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    To fulfill the criteria for autism spectrum disorder (ASD), symptoms must be present across domains and contexts. We assessed preschool staff’s ratings of social communication and interaction (SCI) and restricted and repetitive behaviors (RRBs) in 3-year-old siblings of children with ASD, either diagnosed (n = 12) or not diagnosed (n = 36) with ASD, and typically developing siblings with no family history of ASD (n = 16). Ratings of SCI were more accurate than RRBs in differentiating the ASD group from the two other groups, and only the SCI ratings correlated with SCI symptoms rated by clinical experts. We conclude that while preschool staff ratings of SCI behaviors are adequate, ratings of RRBs should be treated with more caution.

    Keywords
    Autism Spectrum Disorder; Early Development; Rating Scales
    National Category
    Social Sciences
    Research subject
    Psychology; Psychology
    Identifiers
    urn:nbn:se:uu:diva-364105 (URN)
    Available from: 2018-10-23 Created: 2018-10-23 Last updated: 2018-10-24
  • Savolainen, Joonatan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    ”Man lär sig utan att man vet att man lär sig”: En studie om musik & sång som redskap i  matematikundervisningen2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Wigren, Anna
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
    Murray, Lawrence
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
    Lindsten, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
    Improving the particle filter in high dimensions using conjugate artificial process noise2018Conference paper (Refereed)
    Abstract [en]

    The particle filter is one of the most successful methods for state inference and identification of general non-linear and non-Gaussian models. However, standard particle filters suffer from degeneracy of the particle weights, in particular for high-dimensional problems. We propose a method for improving the performance of the particle filter for certain challenging state space models, with implications for high-dimensional inference. First we approximate the model by adding artificial process noise in an additional state update, then we design a proposal that combines the standard and the locally optimal proposal. This results in a bias-variance trade-off, where adding more noise reduces the variance of the estimate but increases the model bias. The performance of the proposed method is empirically evaluated on a linear-Gaussian state space model and on the non-linear Lorenz'96 model. For both models we observe a significant improvement in performance over the standard particle filter.

  • Mårtensson, Nils
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics. Uppsala Univ, Dept Phys & Astron, Box 516, SE-75120 Uppsala, Sweden.
    Eriksson, Mikael
    Lund Univ, MAX Lab 4, Box 118, SE-22100 Lund, Sweden.
    The saga of MAX IV, the first multi-bend achromat synchrotron light source2018In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 907, p. 97-104Article, review/survey (Refereed)
    Abstract [en]

    This paper describes how MAX IV, the first Multi-Bend Achromat (MBA) Synchrotron Radiation Light Source, was developed and realized. It describes the process of defining the scientific case and the development of the accelerator concepts. This was a highly interactive and intense optimization process, which went on during a long time with tight communication between the laboratory and the various user communities as well as with the funding agencies.

  • Elfström, Åsa
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Physical Geography.
    Geomorfologiska studier av talus, svämkäglor och mudflows inom valda lokaler, Isfjorden, Spetsbergen1978Independent thesis Basic level (degree of Bachelor)Student thesis
    Abstract [sv]

    Inledning:

    Uppgiften, som den presenterades för mig i juni 1976, var att göra en allmän morfologisk beskrivning av några olika typer av sluttningsdepositioner samt deras partikelorientering.

    Huvudlokal har varit Skansbukta på Spetsbergen, där välutbildade talusbranter och svämkäglor finnes. Speciellt intresse har ägnats åt studiet av dessa depositionsformer. Vidare har även depositioner i anslutning till de talrika mudflows studerats. Jämförande studier beträffande ovanstående former har gjorts vid två andra lokaler, nämligen Longyeardalen och en lokal, som av handledaren tilldelats arbetsnamnet Timglaset.

    Arbetet har främst omfattat en beskrivning av sluttningsdepositionerna som gjorts på basis av profildragningar, grävda skärningar, partikelorientering samt okulär besiktning. Först i andra hand har processernas förlopp diskuterats.

  • Public defence: 2018-12-13 09:15 80101, Uppsala
    Forslund, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity. 198508136911.
    Studies of a Vertical Axis Turbine for Marine Current Energy Conversion: Electrical system and turbine performance2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Ocean energy is a field of growing interest when it comes to renewable energy thanks to its high density of energy per unit area, and to the high predictability. Conversion of hydrokinetic energy, found in marine currents, is the utilization of the energy in free-flowing water for conversion to electric energy. This thesis presents experimental data from a test site with a marine current converter.

    The converter system features a vertical axis turbine directly connected to a permanent magnet synchronous generator placed on the riverbed. The converter is controlled by an electrical system. The focus of the work is to evaluate power control methods and turbine performance.  

    Results of a simple voltage control system is presented and compared with operation without control. The turbine type in the converter system is not self-starting. The startup power and energy has been investigated through experiments. The converter system has been connected to the local electric utility grid and the first experimental results are presented.  

    The performance of the turbine for a range of water speeds is investigated. The range of experiments are limited by the water velocity at the experimental site. To address the issue, a simulation model coupling the electrical system and hydrodynamic model into one has been validated. One factor affecting the turbine's power capture is the angle of the blade pitch relative to the water flow. The influence of blade pitch on turbine performance is studied with experiments and two 3D simulation models.

    The possibilities of powering a desalination plant using marine current converters is discussed. Water speed data from outside the east coast of South Africa has been used for a case study. The study investigates how many people can early be supplied with freshwater using the converter system at the experimental site as a model. 

    List of papers
    1. The Söderfors Project: Experimental Hydrokinetic Power Station Deployment and First Results
    Open this publication in new window or tab >>The Söderfors Project: Experimental Hydrokinetic Power Station Deployment and First Results
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    2013 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    The Division of Electricity at Uppsala University recently deployed an experimental hydrokinetic power station for in-stream experiments at a site in a river. This paper briefly describes the deployment process and reports some initial results from measurements made at the test site.

    Keywords
    Marine Current Power, Renewable energy, Söderfors, Strömkraft, Förnybar energi, Söderfors
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-209220 (URN)
    Conference
    10th European Wave and Tidal Energy Conference (EWTEC), 2-5 september, 2013, Aalborg, Denmark
    Projects
    Marine Current Power
    Funder
    StandUpSwedish Research Council, 621-2009-4946
    Available from: 2013-10-15 Created: 2013-10-15 Last updated: 2018-10-25Bibliographically approved
    2. Experimental Results of a Load-Controlled Vertical Axis Marine Current Energy Converter
    Open this publication in new window or tab >>Experimental Results of a Load-Controlled Vertical Axis Marine Current Energy Converter
    2015 (English)Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis investigates the load control of a marine current energy converter using a vertical axis turbine mounted on a permanent magnet synchronous generator. The purpose of this thesis is to show the work done in the so far relatively uncharted territory of control systems for hydro kinetic energy conversion. The work is in its early stage and is meant to serve as a guide forfuture development of the control system.

    An experimental power station has been deployed and the first results are presented.

    A comparison between three load control methods has been made; a fixedAC load, a fixed pulse width modulated DC load and a DC bus voltage control of a DC load. Experimental results show that the DC bus voltage control reduces the variation of rotational speed with a factor of 3.5. For all three cases, the tip speed ratio of the turbine can be kept close to the expected optimal tip speed ratio. However, for all three cases the average extracted power was significantly lower than the average power available in the turbine times the estimated maximum power coefficient. A maximum power point tracking system, with or without water velocity measurement, should increase the average extracted power.

    A simulation model has been validated using experimental data. The simulated system consists of the electrical system and a hydrodynamic vortex model for the turbine. Experiments of no load operation were conducted to calibrate the drag losses of the turbine. Simulations were able to predict the behaviour in a step response for a change in tip speed ratio when the turbine was operated close to optimal tip speed ratio. The start position of the turbine was varied in the simulation to view the influence on the step response from a changed turbine position relative to the direction of the water flow.

    Place, publisher, year, edition, pages
    Uppsala: Uppsala universitet, 2015. p. 53
    Series
    UURIE / Uppsala University, Department of Engineering Sciences, ISSN 0349-8352 ; 345-15L
    Keywords
    Marine Current; Vertical Axis; Load Control;
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-268867 (URN)
    Presentation
    2015-12-16, Å4101, Lägerhyddsvägen 1, Ångströmlaboratoriet, Uppsala, 09:15 (English)
    Opponent
    Supervisors
    Funder
    StandUpÅForsk (Ångpanneföreningen's Foundation for Research and Development)Vattenfall ABSwedish Research CouncilSwedish Energy Agency
    Note

    Funders: J Gust Richert, Bixia Miljöfond

    Available from: 2015-12-10 Created: 2015-12-10 Last updated: 2018-10-25Bibliographically approved
    3. Power And Energy Needed For Starting A Vertical Axis Marine Current Turbine
    Open this publication in new window or tab >>Power And Energy Needed For Starting A Vertical Axis Marine Current Turbine
    2017 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    A marine current power station has been deployed in Söderfors, Sweden. It comprises a five bladed fixed pitch vertical axis H-rotor turbine directly connected to a permanent magnet synchronous generator. The turbine is rated for 1.3 m/s, but at lower water speeds the turbine is generally not self starting. This paper investigates the energy and power needed to at low speeds start the turbine electrically with a BrushLess DC (BLDC) motor until  he turbines gives a net positive torque to the generator. A range of startup BLDC powers have been investigated. It is shown that for three water speeds (0.98 m/s, 1.04 m/s and 1.16 m/s) the energy needed for start up is equivalent to less than 1.2 s of power production at maximum power capture of the turbine. The startup time is mostly dependent on BLDC power setting, not on water speed. A BLDC power of 1/7th of rated power of the machine is enough to start the machine within 2 seconds. The results suggest that a higher BLDC power than that will not significantly reduce the startup time nor reduce the energy needed (increase the efficiency of the startup process). The water speed has the highest impact on the time it takes to recover the energy needed for startup once the BLDC power is well above the losses in the system.

    Keywords
    Marine current power, startup energy, Söderfors, vertical axis turbine
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-330188 (URN)
    Conference
    Proceedings of the 12th European Wave and Tidal Energy Conference 27th Aug -1st Sept 2017, Cork, Ireland
    Projects
    Marine Current Power
    Funder
    Vattenfall ABStandUpÅForsk (Ångpanneföreningen's Foundation for Research and Development)Swedish Energy AgencySwedish Research Council
    Available from: 2017-09-27 Created: 2017-09-27 Last updated: 2018-10-25Bibliographically approved
    4. First Experimental Results of a Grid Connected Vertical Axis Marine Current Turbine using a Multilevel Power Converter
    Open this publication in new window or tab >>First Experimental Results of a Grid Connected Vertical Axis Marine Current Turbine using a Multilevel Power Converter
    2018 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    An experimental marine current power station has been deployed in Söoderfors, Sweden. It comprises a vertical axis turbine directly connected to a permanent magnet synchronous generator rated at 7.5 kW. The generator is controlled by a Back-To-Back 2L-3L Cascaded H-Bridge full scale bi-directional Power Converter located on shore. This paper presents the first test results of the power converter, including grid connection. The startup of  the turbine, power extraction and initial active power injection to the grid, at 50 % of rated power, operated as predicted by laboratory experiments and simulations. After 40 seconds of grid connection the safety system disconnect the grid converter due to high currents injected to the grid. The problem is mostly likely associated with the current controller in the dq0 frame. Further tuning of the PI regulators and the potential addition of an anti-windup could mitigate the control issue.

    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-360576 (URN)
    Conference
    4th Asian Wave and Tidal Energy Conference (AWTEC). Taipei, Taiwan, 9-13 September 2018.
    Funder
    StandUpÅForsk (Ångpanneföreningen's Foundation for Research and Development)Swedish Research CouncilSwedish Energy AgencyVattenfall AB
    Available from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-10-25Bibliographically approved
    5. Experimental demonstration of performance of a vertical axis marine current turbine in a river
    Open this publication in new window or tab >>Experimental demonstration of performance of a vertical axis marine current turbine in a river
    Show others...
    2016 (English)In: Journal of Renewable and Sustainable Energy, ISSN 1941-7012, E-ISSN 1941-7012, Vol. 8, no 6, article id 064501Article in journal (Refereed) Published
    Abstract [en]

    An experimental station for marine current power has been installed in a river. The station comprises a vertical axis turbine with a direct-driven permanent magnet synchronous generator. In measurements of steady-state operation in varying flow conditions, performance comparable to that of turbines designed for significantly higher flow speeds is achieved, demonstrating the viability of electricity generation in low speed (below 1.5 m/s) marine currents.

    Keywords
    Ocean currents, electric currents, rivers, hydrodynamics, torque
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering Ocean and River Engineering
    Research subject
    Engineering Science with specialization in Science of Electricity
    Identifiers
    urn:nbn:se:uu:diva-280762 (URN)10.1063/1.4971817 (DOI)000390115300019 ()
    Projects
    Marin strömkraft
    Funder
    Vattenfall ABÅForsk (Ångpanneföreningen's Foundation for Research and Development)StandUp
    Note

    Övriga finansiärer: J. Gust. Richert Memorial Fund och Bixia Environmental Fund.

    Available from: 2016-03-15 Created: 2016-03-15 Last updated: 2018-10-25Bibliographically approved
    6. Validation of a Coupled Electrical and Hydrodynamic Simulation Model For A Vertical Axis Marine Current Energy Converter
    Open this publication in new window or tab >>Validation of a Coupled Electrical and Hydrodynamic Simulation Model For A Vertical Axis Marine Current Energy Converter
    2018 (English)In: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 11, article id 3067Article in journal (Refereed) Published
    Abstract [en]

    This paper validates a simulation model for a Vertical Axis Turbine connected to a Permanent Magnet Synchronous Generator in a direct drive configuration. The simulated system consists of the electrical system and a hydrodynamicvortex model for the turbine. Experiments of no load operation were conducted to calibratethe drag losses of the turbine. Simulations were able to predict the behaviour of a stepresponse for a change in Tip Speed Ratio (TSR) when the turbine was operated close to optimal TSR. The turbine start position could be changed to view the influence of changed relative position of the turbine to the water flow in the step response.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-267944 (URN)10.3390/en11113067 (DOI)
    Funder
    StandUpÅForsk (Ångpanneföreningen's Foundation for Research and Development)Vattenfall ABSwedish Research CouncilSwedish Energy AgencyVattenfall AB
    Note

    Funders: J Gust Richert, Bixia Miljöfond

    Available from: 2015-12-10 Created: 2015-11-30 Last updated: 2018-11-07Bibliographically approved
    7. Impact of Blade Pitch Angle on Turbine Performance of a Vertical Axis Current Turbine
    Open this publication in new window or tab >>Impact of Blade Pitch Angle on Turbine Performance of a Vertical Axis Current Turbine