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  • Hedlund, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Signals and Systems Group.
    Design of a UAV-based radio receiver for avalanche beacon detection using software defined radio and signal processing2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    A fully functional proof of concept radio receiver for detecting avalanche beacons atthe frequency 457 kHz was constructed in the work of this master thesis. The radioreceiver is intended to be mounted on an unmanned aerial vehicle (UAV or drone)and used to aid the mountain rescue teams by reducing the rescue time in findingavalanche victims carrying a transmitting beacon. The main parts of this master thesisinvolved hardware requirement analysis, software development, digital signalprocessing and wireless communications.

    The radio receiver was customized to receive low power signal levels becausemagnetic antennas are used and the avalanche beacon will operate in the reactive nearfield of the radio receiver. Noise from external sources has a significant impact on theperformance of the radio receiver.

    This master thesis allows for straightforward further development and refining of theradio receiver due to the flexibility of the used open-source software development kitGNU Radio where the digital signal processing was performed.

  • Larsson, Frans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    The Greenium: A study of pricing on the fixed income market2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis studies the yield differential between green bonds and conventional bonds, the so called green premium or "greenium". By deriving a theoretical model that includes investors' preferences for green assets, two hypothesis are formulated: There exists a negative green bond premium and The negative premium is larger in absolute terms in countries with high environmental performance. In order to estimate the premium, synthetic conventional bonds are constructed having the same characteristics as the green bonds. Two different matching methods are used to construct the synthetic bonds, one based on maturity and one based on correlation. The findings of this study suggest a significant negative green premium between -0.29 and -0.78 basis points. Also, the green premium is more than twice as large, in terms of absolute value, if the issuer is based in a country which has a high environmental performance.

  • Gauraha, Niharika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Spjuth, Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Synergy Conformal Prediction for RegressionManuscript (preprint) (Other academic)
    Abstract [en]

    Large and distributed data sets pose many challenges for machine learning, including requirements on computational resources and training time. One approach is to train multiple models in parallel on subsets of data and aggregate the resulting predictions. Large data sets can then be partitioned into smaller chunks, and for distributed data the need for pooling can be avoided. Combining results from conformal predictors using synergy rules has been shown to have advantageous properties for classification problems. In this paper we extend the methodology to regression problems, and we show that it produces valid and efficient predictors compared to inductive conformal predictors and cross-conformal predictors for 10 different data sets from the UCI machine learning repository using three different machine learning methods. The approach offers a straightforward and compelling alternative to pooling data, such as when working in distributed environments.

  • Public defence: 2019-03-08 13:15 Hörsal 2, Ekonomikum, Uppsala
    Sepahvand, Mohammad H.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Essays on Risk Attitudes in Sub-Saharan Africa2019Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Essay I (submitted): Risk-taking is an important topic in Africa, as access to financial institutions and social security is scarce. Data on risk attitudes in Africa is limited and the available data collected might not be reliable. We investigate the determinants of risk attitudes in different domains and the reliability of survey data in a sub-Saharan African country, Burkina Faso, using a large representative panel survey of 31,677 individuals. Our results show that determinants such as individual’s sex and age are significantly associated with willingness to take risk. Reliability differs across determinants of risk taking and risk domains. Women, older individuals or those with high education have more reliable risk measures compared to men, younger individuals or people with low education. Risk taking in traffic has the highest test-retest reliability followed by willingness to take risk in general and financial matters.

  • Weiberg, Erika
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history.
    Bevan, Andrew
    Kouli, Katerina
    Katsianis, Markos
    Woodbridge, Jessie
    Bonnier, Anton
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history.
    Engel, Max
    Finné, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history.
    Fyfe, Ralph
    Maniatis, Yannis
    Palmisano, Alessio
    Panajiotidis, Sampson
    Roberts, Neil
    Shennan, Stephen
    Long-term trends of land use and demography in Greece: A comparative study2019In: The Holocene, ISSN 0959-6836, E-ISSN 1477-0911Article in journal (Refereed)
    Abstract [en]

    This paper offers a comparative study of land use and demographic development in northern and southern Greece from the Neolithic to the Byzantine period. Results from summed probability densities (SPD) of archaeological radiocarbon dates and settlement numbers derived from archaeological site surveys are combined with results from cluster-based analysis of published pollen core assemblages to offer an integrated view of human pressure on the Greek landscape through time. We demonstrate that SPDs offer a useful approach to outline differences between regions and a useful complement to archaeological site surveys, evaluated here especially for the onset of the Neolithic and for the Final Neolithic (FN)/Early Bronze Age (EBA) transition. Pollen analysis highlight differences in vegetation between the two sub-regions, but also several parallel changes. The comparison of land cover dynamics between two sub-regions of Greece further demonstrates the significance of the bioclimatic conditions of core locations and that apparent oppositions between regions may in fact be two sides of the same coin in terms of socio-ecological trajectories. We also assess the balance between anthropogenic and climate-related impacts on vegetation and suggest that climatic variability was as an important factor for vegetation regrowth. Finally, our evidence suggests that the impact of humans on land cover is amplified from the Late Bronze Age (LBA) onwards as more extensive herding and agricultural practices are introduced.

  • Public defence: 2019-03-08 09:15 B8; BMC, Uppsala
    Saez-Ibañez, Ana Rosa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. ErbB3 is also an important player in cancer progression, where it mediates resistance to EGFR inhibitors and promotes metastasis.

    In this thesis we have identified, first, a role of ErbB3 in promoting vesicular recycling of different cargoes, as β1-Integrin or E-cadherin. Vesicular recycling is the process by which  cargo proteins are internalized and delivered back to the plasma membrane. This process allows fine tuning of the cargoes function, adjusting their availability on the membrane to different conditions. In the case of β1-Integrin, an important adhesion receptor that mediates association of cells with the extracellular matrix, proper recycling is required for cellular adhesion and migration, among other functions. E-cadherin, on the other hand, is the major cell-to-cell junctional molecule in between epithelial cells, and therefore its availability at the plasma membrane is required for the formation and maintenance of epithelial tissues.

    In addition, we also present the finding that ErbB3 plays a role in exosome release. Exosomes are small extracellular vesicles originated from the fusion of multivesicular bodies with the plasma membrane. Exosomes are crucial for intercellular communication and are able to act as cargo delivery units both under physiological conditions and in the context of disease. Our work shows that ErbB3 inhibits exosome release and dictates their cargo composition, which may have important implications for their function.

    Finally, we have also investigated novel mechanisms for regulation of ErbB3 function. Therefore, this thesis also includes our work on non-receptor tyrosine kinase Ack1, a multifaceted kinase which has been extensively linked to tumour progression and cancer cell survival. We show for the first time that Ack1 acts as an important negative regulation of ErbB3 protein level.

    Altogether, this thesis contributes to our understanding of ErbB3 cellular functions and modes of regulation, unveiling new roles of this RTK in vesicular trafficking and exosome release, and proposing Ack1 as a novel modulator of its function.  

    List of papers
    1. Ligand-independent role of ErbB3 in endocytic recycling
    Open this publication in new window or tab >>Ligand-independent role of ErbB3 in endocytic recycling
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-373809 (URN)
    Available from: 2019-01-16 Created: 2019-01-16 Last updated: 2019-01-16
    2. Ligand-independent role of ErbB3 in recycling of E-cadherin and assembly of adherens junctions
    Open this publication in new window or tab >>Ligand-independent role of ErbB3 in recycling of E-cadherin and assembly of adherens junctions
    (English)Manuscript (preprint) (Other academic)
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-373806 (URN)
    Available from: 2019-01-16 Created: 2019-01-16 Last updated: 2019-01-16
    3. ErbB3 regulates release of extracellular vesicles
    Open this publication in new window or tab >>ErbB3 regulates release of extracellular vesicles
    (English)Manuscript (preprint) (Other academic)
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-373808 (URN)
    Available from: 2019-01-16 Created: 2019-01-16 Last updated: 2019-01-16
    4. Ack1 is a negative regulator of ErbB3 that acts both by promoting its degradation and suppressing its expression.
    Open this publication in new window or tab >>Ack1 is a negative regulator of ErbB3 that acts both by promoting its degradation and suppressing its expression.
    (English)Manuscript (preprint) (Other academic)
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:uu:diva-373813 (URN)
    Available from: 2019-01-16 Created: 2019-01-16 Last updated: 2019-01-16
  • Schoffelen, Paul F. M.
    et al.
    Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Human Biol, Maastricht, Netherlands;Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Nutr & Movement Sci, Maastricht, Netherlands.
    den Hoed, Marcel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    van Breda, Eric
    Univ Antwerp, Dept Rehabil Sci & Physiotherapy, MOVANT, Fac Med & Hlth Sci, Antwerp, Belgium.
    Plasqui, Guy
    Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Nutr & Movement Sci, Maastricht, Netherlands.
    Test-retest variability of VO2max using total-capture indirect calorimetry reveals linear relationship of VO2 and Power2019In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 29, no 2, p. 213-222Article in journal (Refereed)
    Abstract [en]

    This study aimed to analyze the intra-individual variation in VO2max of human subjects using total-capture and free-flow indirect calorimetry. Twenty-seven men (27 ± 5 year; VO2max 49-79 mL•kg-1 •min-1) performed two maximal exertion tests (CPETs) on a cycle ergometer, separated by a 7 ± 2 day interval. VO2 and VCO2 were assessed using an indirect calorimeter (Omnical) with total capture of exhalation in a free-flow airstream. Thirteen subjects performed a third maximal exertion test using a breath-by-breath calorimeter (Oxycon Pro). On-site validation was deemed a requirement. For the Omnical, the mean within-subject CV for VO2max was 1.2 ± 0.9% (0.0%-4.4%) and for ergometer workload P max 1.3 ± 1.3% (0%-4.6%). VO2max values with the Oxycon Pro were significantly lower in comparison with Omnical (P< t 0.001; t test) with mean 3570 vs 4061 and difference SD 361 mL • min-1. Validation results for the Omnical with methanol combustion were -0.05 ± 0.70% (mean ± SD; n = 31) at the 225 mL • min-1 VO2 level and -0.23 ± 0.80% (n = 31) at the 150 mL • min-1 VCO2 level. Results using gas infusion were 0.04 ± 0.75% (n = 34) and -0.99 ± 1.05% (n = 24) over the respective 500-6000 mL • min-1 VO2 and VCO2 ranges. Validation results for the Oxycon Pro in breath-by-breath mode were - 2.2 ± 1.6% (n = 12) for VO2 and 5.7 ± 3.3% (n = 12) for VCO2 over the 1000-4000 mL •min-1 range. On a Visual analog scale, participants reported improved breathing using the free-flow indirect calorimetry (score 7.6 ± 1.2 vs 5.1 ± 2.7, P = 0.008). We conclude that total capturing free-flow indirect calorimetry is suitable for measuring VO2 even with the highest range. VO2max was linear with the incline in P max over the full range.

  • Norbäck, Dan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China;Cent S Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.
    Lu, Chan
    Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China;Cent S Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.
    Zhang, Yinping
    Tsinghua Univ, Sch Architecture, Beijing, Peoples R China.
    Li, Baizhan
    Chongqing Univ, Key Lab Three Gorges Reservoir Reg Ecoenvironm, Chongqing, Peoples R China.
    Zhao, Zhuohui
    Fudan Univ, Dept Environm Hlth, Shanghai, Peoples R China.
    Huang, Chen
    Shanxi Univ, Inst Environm Sci, Taiyuan, Shanxi, Peoples R China.
    Zhang, Xin
    Univ Shanghai Sci & Technol, Sch Environm & Architecture, Shanghai, Peoples R China.
    Qian, Hua
    Southeast Univ, Sch Energy & Environm, Nanjing, Jiangsu, Peoples R China.
    Sun, Yuexia
    Tianjin Univ, Sch Environm Sci & Engn, Tianjin, Peoples R China.
    Sundell, Jan
    Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China;Tianjin Univ, Sch Environm Sci & Engn, Tianjin, Peoples R China.
    Wang, Juan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. Chongqing Univ, Key Lab Three Gorges Reservoir Reg Ecoenvironm, Chongqing, Peoples R China.
    Liu, Wei
    Tsinghua Univ, Sch Architecture, Beijing, Peoples R China.
    Deng, Qihong
    Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China;Cent S Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.
    Onset and remission of childhood wheeze and rhinitis across China: Associations with early life indoor and outdoor air pollution2019In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 123, p. 61-69Article in journal (Refereed)
    Abstract [en]

    Objective: Few longitudinal studies exist on childhood exposure to indoor and outdoor air pollution and respiratory illness in China. We studied associations between indoor and outdoor environment and prevalence, onset and remission of wheeze and rhinitis among children across China.

    Methods: Children (3-6 y) were recruited from randomized day care centres in six cities. The main data analysis was restricted to children not moving since birth (N = 17,679). Data on wheeze, rhinitis and the home environment were assessed by a parental questionnaire. Prevalence in the first two years of life (baseline) and the last year (follow-up) was used to calculate onset and remission. Outdoor PM2.5, PM10, and NO2 at the day care centre were modelled from monitoring station data. Associations were calculated by multilevel logistic regression.

    Results: Prenatal NO2 was associated with decreased remission of wheeze and increased prevalence and increased onset of rhinitis. Prenatal PM2.5 was associated with increased prevalence of wheeze. Postnatal NO2 and postnatal PM10 were associated with increased prevalence and lower remission of wheeze and rhinitis. Mould, window pane condensation, renovation and cockroaches at home were associated with increased prevalence and increased onset of wheeze and rhinitis. Gas cooking was associated with increased onset of rhinitis. Children of mothers with industrial work had more wheeze.

    Conclusions: Outdoor PM2.5, PM10 and NO2 can increase childhood wheeze and rhinitis. Dampness and mould can increase onset and decrease remission. Crowdedness, cockroaches at home and emissions from new building materials and gas cooking can be risk factors for wheeze and rhinitis.

  • Public defence: 2019-03-08 10:00 Häggsalen, Uppsala
    Shameem, Muhammad Anwar
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Low-Coordinate Organopnictogens: Synthesis and Optoelectronic properties2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis work is based on the development of novel organopnictogen compounds and the exploration of their potential applications in organic electronics. In particular, incorporation of phosphorus and arsenic into π-conjugated systems is known to modify the optoelectronic properties.

    The first chapter of this thesis is fully devoted to the development of a metal-free synthetic route that allows direct, sequential and stereoselective alkynylation of C,C-dibromophosphaalkenes. The subsequent unusual reactivity of thus synthesized C-mono and C,C-diacetylenicphosphaalkenes with terminal acetylenes afforded highly substituted 1-phoshpha-1,3-butadienes heavier analogue of all carbon 1,3-butadiene motifs. Optimization of the reaction condition favored exclusively the formation of 1-phospha-1,3-butadienes. Unveiling the unique cyclization of the 3-yne 1-phospha-1,3-butadiene gave highly substituted phosphole derivatives. Further, it has been experimentally shown that the P=C unit is essential for this rare cyclization and rearrangement to give π-conjugated phosphole derivatives.

    The second chapter of this thesis work deals with incorporation of P/As in the form of phosphinidene and or arsinidene units as an exocyclic substituent at the bridge of the fused rigid cyclpentadithiophenes (p-CPDT) core. Furthermore, it demonstrates how this chemical modification at the bridgehead position selectively lowers the LUMO level. At a later stage, substitutions at α and α` positions of the central CPDT core was used to modify the HOMO level without further affecting the LUMO level. We also performed DFT calculations on these phosphinide/arsinidene p-CPDT derivatives to theoretical evaluate the impact of P and or As incorporation. The phosphinidene/arsinidene p-CPDT derivatives were fully characterized using electrochemical and optical spectroscopic techniques including transient absorption spectroscopy. Additionally, the arsinidene-p-CPDT were electrochemically polymerized, and the resultant polymer film was characterized by means of SEM and EDX.

    The last chapter of this research work is dealing with the exploration and functionalization of open-ended small fragments of fullerene-C60 such as sumanene and truxene. Functionalisation of these motifs was achieved via the introduction of pnictogens (P/As), either in the form of phosphinidene/arsinidene or as heteroles. The optoelectronic spectra of the unprecedented pnictinidenotruxene exhibited significantly redshift absorption and three fully reversible reduction events upon electrochemical reduction.

    List of papers
    1. Direct, Sequential, and Stereoselective Alkynylation of C,C-Dibromophosphaalkenes
    Open this publication in new window or tab >>Direct, Sequential, and Stereoselective Alkynylation of C,C-Dibromophosphaalkenes
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    2016 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 22, no 30, p. 10614-10619Article in journal (Refereed) Published
    Abstract [en]

    The first direct alkynylation of C,C-dibromophosphaalkenes by a reaction with sulfonylacetylenes is reported. Alkynylation proceeds selectively in the trans position relative to the P substituent to afford bromoethynylphosphaalkenes. Owing to the absence of transition metals in the procedure, the previously observed conversion of dibromophosphaalkenes into phosphaalkynes through the phosphorus analog of the Fritsch-Buttenberg-Wiechell rearrangement is thus suppressed. The bromoethynylphosphaalkenes can subsequently be converted to C,C-diacetylenic, cross-conjugated phosphaalkenes by following a Sonogashira coupling protocol in good overall yields. By using the newly described method, full control over the stereochemistry at the P=C double bond is achieved. The substrate scope of this reaction is demonstrated for different dibromophosphaalkenes as well as different sulfonylacetylenes.

    Keywords
    alkynylation, cross-conjugation, phosphaalkenes, Sonogashira coupling, sulfonyl coupling
    National Category
    Inorganic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-302705 (URN)10.1002/chem.201601955 (DOI)000380273300043 ()27310813 (PubMedID)
    External cooperation:
    Funder
    Swedish Research CouncilCarl Tryggers foundation
    Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2019-01-18Bibliographically approved
    2. Highly branched 2,3-diyne-1-phospha-1,3-butadiene motifs via Pd/Cu mediated alkynyl addition
    Open this publication in new window or tab >>Highly branched 2,3-diyne-1-phospha-1,3-butadiene motifs via Pd/Cu mediated alkynyl addition
    (English)Manuscript (preprint) (Other academic)
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:uu:diva-373905 (URN)
    Available from: 2019-01-17 Created: 2019-01-17 Last updated: 2019-01-18
    3. Synthesis and Characterization of Cyclopentadithiophene Heterofulvenes: Design Tools for Light-Activated Processes
    Open this publication in new window or tab >>Synthesis and Characterization of Cyclopentadithiophene Heterofulvenes: Design Tools for Light-Activated Processes
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    2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 24, p. 5673-5677Article in journal (Refereed) Published
    Abstract [en]

    The development of new materials for solar-to-energy conversion should consider stability, ease of fabrication, and beneficial photophysical properties. In this context, a set of novel -conjugated building blocks, with phospha- and arsaalkenes possessing a unique dithienyl annulated heterofulvenoid core, have been prepared as air- and moisture-stable sensitizers. These compounds unify electron-donor and -acceptor moieties, making them potential candidates for light-harvesting applications. Optical characterization of these systems was performed by steady-state and time-resolved absorption spectroscopy, supported by time-dependent DFT calculations. Tuning of the optical properties of these systems can be achieved by varying the pnictogen element at the bridgehead position, giving a bathochromic shift of approximate to 40nm and coordinating the phosphaalkene towards gold Au-I centers. The latter results in a approximate to 2000-fold extension of the approximate to 10ps lifetime of uncoordinated systems well into the ns regime.

    Place, publisher, year, edition, pages
    WILEY-V C H VERLAG GMBH, 2017
    Keywords
    arsaalkene, electrochemistry, main group elements, phosphaalkene, pnictogens, time-resolved spectroscopy
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:uu:diva-322721 (URN)10.1002/chem.201700917 (DOI)000400044400006 ()28248442 (PubMedID)
    Funder
    Swedish Research Council, 2013-4763Knut and Alice Wallenberg FoundationÅForsk (Ångpanneföreningen's Foundation for Research and Development)
    Available from: 2017-05-29 Created: 2017-05-29 Last updated: 2019-01-18Bibliographically approved
  • Sepahvand, Mohammad H
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics. Uppsala Universitet.
    Agricultural productivity in Burkina Faso: The role of gender and risk attitudes2019Report (Other academic)
    Abstract [en]

    This study is an empirical investigation of how individual risk attitudes influence the agricultural productivity of men and women in a sub-Saharan African country, Burkina Faso. By analyzing a large representative panel survey of farmers from 2014 and 2015, the results indicate lower productivity on female-owned plots. Controlling for various socio-economic factors, the results show that as the female farmers’ increase risk taking, the productivity of female-owned plots goes down. These results are robust regarding alternative specifications. However, productivity differences vary by the type of crop cultivated, the agro-ecological zone, the share of female farmers in the region, the soil quality, type of seed used, and between consumption quantiles when comparing the poorest to the richest 20 per cent of the farm households. The results indicate that female farmers do not increase their plot yield by taking more risk. It is argued that agricultural policy interventions in Burkina Faso need to be gender sensitized when addressing issues related to credit constraints, improved inputs, and policies that support increase in productivity.

  • Dunn, Michael
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Dewey, Tonya Kim
    Univ Nottingham, Nottingham, England.
    Arnett, Carlee
    University of California, Davis, USA.
    Eythorsson, Thorhallur
    Univ Iceland, Reykjavik, Iceland.
    Barddal, Johanna
    Univ Ghent, Ghent, Belgium.
    Dative sickness: Aphylogenetic analysis of argument structure evolution in Germanic2017In: Language, ISSN 0097-8507, E-ISSN 1535-0665, Vol. 93, no 1, p. E1-E22Article in journal (Refereed)
    Abstract [en]

    A major argument against the feasibility of reconstructing syntax for proto-stages is the widely discussed lack of directionality of syntactic change. In a recent typology of changes in argument structure constructions based on Germanic (Barodal 2015), several different, yet opposing, changes are reported. These include, among others, processes sometimes called dative sickness, nominative sickness, and accusative sickness. In order to tease apart the roles of the different processes, we have carried out a phylogenetic trait analysis on a predefined data set of twelve predicates found across the Germanic phyla using the MULTISTATE method. This is, as far as we are aware, the first application of the MULTISTATE method (Pagel et al. 2004) in historical syntax. The results clearly favor one of the models, the dative sickness model, over any other model, as this model is the only one that can accurately account for both the observed diversity of case frames and the independently proposed philological reconstructions. Methods of evolutionary trait analysis can be used to model evolutionary paths of argument structure constructions, and they provide the perfect testing ground for hypotheses arrived at through philological reconstruction, based on classical historical-comparative methods.

  • Public defence: 2019-03-08 13:15 Enghoff lecture-hall, Uppsala
    Lundkvist, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Metabolic and endocrine effects of SGLT2 inhibition2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Obesity and type 2 diabetes (T2D) are two growing global health problems with similar comorbidity profiles. SGLT2 inhibitors (SGLT2i) improve blood glucose control and can relieve both T2D and obesity, as well as their associated health problems such as hypertension, kidney failure, and cardiovascular disease.

    In paper I, 50 obese patients without diabetes were treated for 24 weeks with SGLT2i dapagliflozin + GLP-1 receptor agonist (GLP-1RA) exenatide or placebo. They were examined regarding body weight loss and body composition. The placebo-adjusted weight loss was 4.13 kg, mostly attributable to adipose tissue loss.

    In paper II, 43 completers of the study in paper I entered a 28-week extension phase in which all participants received active treatment. We found major reductions in body weight, adipose tissue volume, blood pressure and prediabetes that were sustained at 52 weeks. 

    In paper III, 84 patients with T2D and non-alcoholic fatty liver disease underwent a 12-week treatment with dapagliflozin, omega-3 (n-3) carboxylic acids (OM-3CA), the combination of both or placebo to assess effects on liver fat content. MRI showed significant reductions of liver fat versus baseline and, for the combination, versus placebo.

    In paper IV: 15 metformin-treated patients with T2D were assessed for changes in plasma glucagon levels following a single dose of dapagliflozin during experiments with stable versus falling plasma glucose. Changes in glucagon levels could largely be explained by changes in glucose levels.

    In conclusion, SGLT2 inhibition can lower body weight and cardiovascular risk factors in obese patients without diabetes when combined with GLP-1RA, and it can reduce liver fat in T2D patients, in particular when given together with OM-3CA. SGLT2i effects on glucagon secretion can largely be explained by lower glucose levels rather than direct α-cell effects.

    List of papers
    1. Dapagliflozin once-daily and exenatide once-weekly dual therapy: A 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes
    Open this publication in new window or tab >>Dapagliflozin once-daily and exenatide once-weekly dual therapy: A 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes
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    2017 (English)In: Diabetes, obesity and metabolism, ISSN 1462-8902, E-ISSN 1463-1326, Vol. 19, no 1, p. 49-60Article in journal (Refereed) Published
    Abstract [en]

    Aims: To explore the effects of dual therapy with dapagliflozin and exenatide on body weight, body composition, glycaemic variables and systolic blood pressure (SBP) in obese adults without diabetes.

    Materials and methods: In this single-centre, double-blind trial, we randomized 50 obese adults without diabetes (aged 18-70 years; body mass index 30-45 kg/m(2)) to oral dapagliflozin 10 mg once daily plus subcutaneous long-acting exenatide 2 mg once weekly or placebo. MRI was used to assess change in body composition. Participants were instructed to follow a balanced diet and exercise moderately.

    Results: Of 25 dapagliflozin/exenatide-and 25 placebo-treated participants, 23 (92.0%) and 20 (80.0%) completed 24 weeks of treatment, respectively. At baseline, the mean participant age was 52 years, 61% were female, the mean body weight was 104.6 kg, and 73.5% of participants had prediabetes (impaired fasting glucose or impaired glucose tolerance). After 24 weeks, for dapagliflozin/exenatide versus placebo: the difference in body weight change was -4.13 kg (95% confidence interval -6.44, -1.81; P <.001), which was mostly attributable to adipose tissue reduction without lean tissue change; 36.0% versus 4.2% of participants achieved >= 5% body weight loss, respectively; and prediabetes was less frequent with active treatment (34.8% vs 85.0%, respectively; P <.01). The difference in SBP change for dapagliflozin/ exenatide versus placebo was -6.7 mm Hg. As expected, nausea and injection-site reactions were more frequent with dapagliflozin/exenatide than with placebo. Only two and three participants, respectively, discontinued because of adverse events.

    Conclusions: Compared with placebo, dapagliflozin/exenatide dual therapy reduced body weight, frequency of prediabetes and SBP over 24 weeks and was well tolerated in obese adults without diabetes.

    Keywords
    dapagliflozin, exenatide, obesity, prediabetes
    National Category
    Endocrinology and Diabetes
    Identifiers
    urn:nbn:se:uu:diva-314407 (URN)10.1111/dom.12779 (DOI)000390987800006 ()
    Funder
    AstraZeneca
    Available from: 2017-02-08 Created: 2017-02-02 Last updated: 2019-01-20Bibliographically approved
    2. Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year
    Open this publication in new window or tab >>Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year
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    2017 (English)In: Diabetes, obesity and metabolism, ISSN 1462-8902, E-ISSN 1463-1326, Vol. 19, no 9, p. 1276-1288Article in journal (Refereed) Published
    Abstract [en]

    Aims: Dapagliflozin and exenatide reduce body weight by differing mechanisms. Dual therapy with these agents reduces body weight, adipose tissue volume, glycaemia and systolic blood pressure (SBP) over 24weeks. Here, we examined these effects over 1year in obese adults without diabetes.

    Materials and methods: Obese adults without diabetes (N=50; aged 18-70years; body mass index, 30-45kg/m(2)) were initially randomized to double-blind oral dapagliflozin 10mg once daily plus subcutaneous long-acting exenatide 2mg once weekly or to placebo. They entered an open-label extension from 24 to 52weeks during which all participants received active treatment.

    Results: Of the original 25 dapagliflozin+exenatide-treated and 25 placebo-treated participants, respectively, 21 (84%) and 17 (68%) entered the open-label period and 16 (64%) and 17 (68%) completed 52weeks of treatment. At baseline, mean body weight was 104.6kg, and 73.5% of participants had prediabetes (impaired fasting glucose or impaired glucose tolerance). Reductions with dapagliflozin+exenatide at 24weeks were sustained at 52weeks, respectively, for body weight (-4.5 and -5.7kg), total adipose tissue volume (-3.8 and -5.3L), proportion with prediabetes (34.8% and 35.3%), and SBP (-9.8 and -12.0mm Hg). Effects on body weight, SBP and glycaemia at 52weeks with placebodapagliflozin+exenatide were similar to those observed with continuation of dapagliflozin+exenatide. Nausea and injection-site reactions were more frequent with dapagliflozin+exenatide than with placebo and diminished over time. Safety and tolerability were similar to that in previous diabetes trials with these agents. No clear difference in adverse event-related withdrawals between placebo and active treatment periods was observed.

    Conclusions: Dapagliflozin+exenatide dual therapy produced sustained reductions in body weight, prediabetes and SBP over 52weeks and was well tolerated in obese adults without diabetes.

    Keywords
    dapagliflozin, exenatide, obesity, prediabetes
    National Category
    Endocrinology and Diabetes
    Identifiers
    urn:nbn:se:uu:diva-334932 (URN)10.1111/dom.12954 (DOI)000408241200010 ()28345814 (PubMedID)
    Funder
    AstraZeneca
    Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2019-01-20Bibliographically approved
    3. Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study
    Open this publication in new window or tab >>Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study
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    2018 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 9, p. 1923-1934Article in journal (Refereed) Published
    Abstract [en]

    Aims/hypothesis The EFFECT-II study aimed to investigate the effects of dapagliflozin and omega-3 (n-3) carboxylic acids (OM-3CA). individually or combined, on liver fat content in individuals with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Methods This randomised placebo-controlled double-blind parallel-group study was performed at five clinical research centres at university hospitals in Sweden. 84 participants with type 2 diabetes and NAFLD were randomly assigned 1:1:1:1 to four treatments by a centralised randomisation system, and all participants as well as investigators and staff involved in the study conduct and analyses were blinded to treatments. Each group received oral doses of one of the following: 10 mg dapagliflozin (n = 21). 4 g OM3-CA (n = 20), a combination of both (n = 22) or placebo (n = 21). The primary endpoint was liver fat content assessed by MRI (proton density fat fraction [PDFF]) and, in addition, total liver volume and markers of glucose and lipid metabolism as well as of hepatocyte injury and oxidative stress were assessed at baseline and after 12 weeks of treatment (completion of the trial). Results Participants had a mean age of 65.5 years (SD 5.9), BMI 31.2 kg/m(2) (3.5) and liver PDFF 18% (9.3). All active treatments significantly reduced liver PDFF from baseline, relative changes: OM-3CA, -15%; dapagliflozin, -13%; OM-3CA + dapagliflozin, -21%. Only the combination treatment reduced liver PDFF (p = 0.046) and total liver fat volume (relative change, -24%,p = 0.037) in comparison with placebo. There was an interaction between the PNPLA31148M polymorphism and change in liver PDFF in the active treatment groups (p = 0.03). Dapagliflozin monotherapy, but not the combination with OM-3CA, reduced the levels of hepatocyte injury biomarkers, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transfcrase (gamma-GT), cytokeratin (CK) 18-M30 and CK 18-M65 and plasma fibroblast growth factor 21 (FGF21). Changes in gamma-GT correlated with changes in liver PDFF (rho = 0.53, p = 0.02). Dapagliflozin alone and in combination with OM-3CA improved glucose control and reduced body weight and abdominal fat volumes. Fatty acid oxidative stress biomarkers were not affected by treatments. There were no new or unexpected adverse events compared with previous studies with these treatments. Conclusions/interpretation Combined treatment with dapagliflozin and OM-3CA significantly reduced liver fat content. Dapagliflozin monotherapy reduced all measured hepatocyte injury biomarkers and FGF21, suggesting a disease-modifying effect in NAFLD.

    Place, publisher, year, edition, pages
    Springer, 2018
    Keywords
    Dapagliflozin, Docosahexaenoic acid, Eicosapentaenoic acid, Liver steatosis, Non-alcoholic fatty liver disease, Omega-3 fatty acids, Proton density fat fraction, Type 2 diabetes
    National Category
    Endocrinology and Diabetes
    Identifiers
    urn:nbn:se:uu:diva-364901 (URN)10.1007/s00125-018-4675-2 (DOI)000440408500005 ()29971527 (PubMedID)
    Funder
    AstraZeneca
    Available from: 2018-11-12 Created: 2018-11-12 Last updated: 2019-01-28Bibliographically approved
    4. Glucagon Levels During Short-Term SGLT2 Inhibition Are Largely Regulated by Glucose Changes in Patients With Type 2 Diabetes.
    Open this publication in new window or tab >>Glucagon Levels During Short-Term SGLT2 Inhibition Are Largely Regulated by Glucose Changes in Patients With Type 2 Diabetes.
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    2019 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 104, no 1, p. 193-201Article in journal (Refereed) Published
    Abstract [en]

    Context: The mechanism mediating sodium glucose cotransporter-2 (SGLT2) inhibitor-associated increase in glucagon levels is unknown.

    Objective: To assess short-term effects on glucagon, other hormones, and energy substrates after SGLT2 inhibition and whether such effects are secondary to glucose lowering. The impact of adding a dipeptidyl peptidase-4 inhibitor was addressed.

    Design, Setting, and Patients: A phase 4, single-center, randomized, three-treatment crossover, open-label study including 15 patients with type 2 diabetes treated with metformin.

    Interventions: Patients received a single-dose of dapagliflozin 10 mg accompanied by the following in randomized order: isoglycemic clamp (experiment DG); saline infusion (experiment D); or saxagliptin 5 mg plus saline infusion (experiment DS). Directly after 5-hour infusions, a 2-hour oral glucose tolerance test (OGTT) was performed.

    Results: Glucose and insulin levels were stable in experiment DG and decreased in experiment D [P for difference (Pdiff) < 0.001]. Glucagon-to-insulin ratio (Pdiff < 0.001), and levels of glucagon (Pdiff < 0.01), nonesterified fatty acids (Pdiff < 0.01), glycerol (Pdiff < 0.01), and β-OH-butyrate (Pdiff < 0.05) were lower in DG vs D. In multivariate analysis, change in glucose level was the main predictor of change in glucagon level. In DS, glucagon and active GLP-1 levels were higher than in D, but glucose and insulin levels did not differ. During OGTT, glucose levels rose less and glucagon levels fell more in DS vs D.

    Conclusion: The degree of glucose lowering markedly contributed to regulation of glucagon and insulin secretion and to lipid mobilization during short-term SGLT2 inhibition.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-373521 (URN)10.1210/jc.2018-00969 (DOI)30137410 (PubMedID)
    Available from: 2019-01-15 Created: 2019-01-15 Last updated: 2019-01-20
  • Wärefors, Linnea
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Clewebrink, Sanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Att växa så det knakar: En studie om den organiska tillväxtens påverkan på en organisations identitet2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie studerar hur organisk tillväxt påverkar en stor organisations identitet och vidare hur den organiska tillväxten påverkar samspelet mellan organisationens identitet och ett företags medarbetarerbjudande. För att undersöka studiens syfte har en fallstudie genomförts på ett stort teknikkonsultföretag som uteslutande vuxit genom organisk tillväxt. Åtta semistrukturerade intervjuer har genomförts med anställda på företaget, detta för att fånga de karaktärsdrag som kan illustrera teknikkonsultföretagets identitet. Empirin visar att följande fem karaktärsdrag: företagets storlek, ägarform och struktur, frihet och flexibilitet, utvecklingsmöjligheter samt hjälpsamhet och öppenhet kan beskriva organisationens identitet. Hur den organiska tillväxten har påverkat teknikkonsultföretagets identitet har främst visat sig genom en ökad anonymitet, en minskad flexibilitet samt en något högre grad av hierarki. Dessutom kan den organiska tillväxten eventuellt bidragit till större utvecklingsmöjligheter. Dock har stora delar av identiteten bevarats vilket kan bero på teknikkonsultföretagets ägarform, en mindre genomförd omorganisation samt att företagets värderingar i form av värdeord genomsyrar och efterlevs i verksamheten. 

  • Olofsson, Jennifer
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Skogberg, Linn
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Tjänsteinnovation genom kundengagemang?: En studie om hur tre olika företag arbetar i kontexten Instagram stories2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Instagram stories är en plattform som sedan lanseringen år 2016 blivit ett populärt marknadsföringsverktyg för företag, utifrån att plattformen anses öppna upp för möjligheter att kunna nyttja kundengagemang. Kundengagemang menas vidare vara användbart i skapandeprocesser, där tjänsteinnovationer på senare tid blivit allt mer omdiskuterat. Detta då värde för både företag och kund kan skapas genom att kunden görs delaktig i skapandeprocessen av nya tjänsteerbjudanden. Hur kundengagemang kan uppnås och vidare nyttjas menas dock vara kontextspecifikt: beroende på sammanhang, vilket är ett begränsat forskningsområde. Studien syftar därmed till att bidra med en större förståelse kring hur företag genom kundengagemang kan uppnå tjänsteinnovationer i en specifik kontext. Detta genom att undersöka hur studiens tre deltagande företag arbetar med samt hanterar kundengagemang för att uppnå tjänsteinnovationer i Instagram stories. Studien är av kvalitativ karaktär och består av två tillvägagångssätt: en innehållsanalys av företagens publicerade kommunikationsinnehåll på Instagram stories samt semistrukturerade intervjuer med företagen. Resultatet har visat att Instagram stories som kontext leder till olika grad av kundengagemang samt tjänsteinnovationer utifrån olika typ av interaktion. Framförallt har företagens interna strukturer samt förmågor i form av rutiner, kompetenser och processer setts vara avgörande för företagens möjlighet att omvandla kunders engagemang till gemensamt framtagna tjänsteinnovationer. Vidare ses hantering av, samt syftet med kundengagemanget, varumärksriktlinjer, samt andra möjligheter till interaktiva relationer med kunden vara avgörande för huruvida företagen i Instagram stories lyckas uppnå tjänsteinnovationer.

  • Boström, Isabella
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Hasselqvist Haglund, Josefin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Att vara eller att inte vara personlig?: En kvantitativ studie om influencermarknadsföring på Instagram2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Influencermarknadsföring är en ny sorts marknadsföringsstrategi som har förändrat dynamiken i hur företag arbetar idag. Många företag använder sig av mediapersonligheter, så kallade influencers, på sociala medier för att göra reklam för sina produkter. Syftet med denna studie är att undersöka om det finns ett samband mellan influencers användning av ett personligt budskap i marknadsföringen av en produkt på Instagram och dennes följares varumärkesattityd och köpintention. Ett personligt budskap definieras enligt teori om emotionell marknadsföring och storytelling. En analysmodell utvecklas med inspiration från Lutz och MacKenzies (1989) modell om attitydbildning kring ett marknadsföringsobjekt. En digital enkätundersökning genomförs med ett personligt/opersonligt fokus där cirka hälften av de 160 respondenterna svarar på enkäten med ett personligt fokus och resterande svarar på samma enkät med ett opersonligt fokus. Syftet med denna indelning är att jämföra huruvida det finns en statistiskt signifikant skillnad mellan de två grupperna. Två av sex formulerade hypoteser om trovärdighet och attityd i relation till influencern och Instagram-inlägget samt varumärkesattityd och köpintention kan accepteras enligt undersökningens resultat.

  • Gravensteen, Ida Kathrine
    et al.
    Oslo Univ Hosp, Dept Forens Sci, Box 4950 Nydalen, N-0424 Oslo, Norway.
    Ekeberg, Öivind
    Univ Oslo, Inst Basic Med Sci, Dept Behav Sci Med, Fac Med, Box 1111 Blindern, N-0317 Oslo, Norway;Oslo Univ Hosp Ullevaal, Div Mental Hlth & Addict, Box 4956 Nydalen, Oslo, Norway.
    Thiblin, Ingemar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Forensic Medicine.
    Helweg-Larsen, Karin
    Univ Copenhagen, Dept Social Med, Copenhagen, Denmark.
    Hem, Erlend
    Univ Oslo, Inst Basic Med Sci, Dept Behav Sci Med, Fac Med, Box 1111 Blindern, N-0317 Oslo, Norway;Oslo Univ Hosp Ullevaal, Div Mental Hlth & Addict, Box 4956 Nydalen, Oslo, Norway.
    Rogde, Sidsel
    Oslo Univ Hosp, Dept Forens Sci, Box 4950 Nydalen, N-0424 Oslo, Norway;Univ Oslo, Inst Clin Med, Box 1072 Blindern, N-0316 Oslo, Norway.
    Töllefsen, Ingvild Maria
    Oslo Univ Hosp Ullevaal, Div Med, Dept Acute Med, Box 4950 Nydalen, N-0424 Oslo, Norway.
    Psychoactive substances in natural and unnatural deaths in Norway and Sweden: a study on victims of suicide and accidents compared with natural deaths in psychiatric patients2019In: BMC Psychiatry, ISSN 1471-244X, E-ISSN 1471-244X, Vol. 19, article id 33Article in journal (Refereed)
    Abstract [en]

    Background: The extent of post-mortem detection of specific psychoactive drugs may differ between countries, and may greatly influence the national death register's classification of manner and cause of death. The main objective of the present study was to analyse the magnitude and pattern of post-mortem detection of various psychoactive substances by the manner of death (suicide, accidental, undetermined and natural death with a psychiatric diagnosis) in Norway and Sweden.

    Methods: The Cause of Death Registers in Norway and Sweden provided data on 600 deaths in 2008 from each country, of which 200 were registered as suicides, 200 as accidents or undetermined manner of death and 200 as natural deaths in individuals with a diagnosis of mental disorder as the underlying cause of death. We examined death certificates and forensic reports including toxicological analyses.

    Results: The detection of psychoactive substances was commonly reported in suicides (66 and 74% in Norway and Sweden respectively), accidents (85 and 66%), undetermined manner of deaths (80% in the Swedish dataset) and in natural deaths with a psychiatric diagnosis (50 and 53%). Ethanol was the most commonly reported substance in the three manners of death, except from opioids being more common in accidental deaths in the Norwegian dataset. In cases of suicide by poisoning, benzodiazepines and z-drugs were the most common substances in both countries. Heroin or morphine was the most commonly reported substance in cases of accidental death by poisoning in the Norwegian dataset, while other opioids dominated the Swedish dataset. Anti-depressants were found in 22% of the suicide cases in the Norwegian dataset and in 29% of suicide cases in the Swedish dataset.

    Conclusions: Psychoactive substances were detected in 66 and 74% of suicides and in 85 and 66% of accidental deaths in the Norwegian and Swedish datasets, respectively. Apart from a higher detection rate of heroin in deaths by accident in Norway than in Sweden, the pattern of detected psychoactive substances was similar in the two countries. Assessment of a suicidal motive may be hampered by the common use of psychoactive substances in suicide victims.

  • Ablikim, M.
    et al.
    Andersson, Walter Ikegami
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Search for a strangeonium-like structure Z(s) decaying into phi pi and a measurement of the cross section e(+)e(-) -> phi pi pi2019In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 99, no 1, article id 011101Article in journal (Refereed)
    Abstract [en]

    Using a data sample of e(+)e(-) collision data corresponding to an integrated luminosity of 108 pb(-1) collected with the BESIII detector at a center-of-mass energy of 2.125 GeV, we study the process e(+)e(-) -> phi pi pi and search for a strangeoniumlike structure Z(s) decaying into phi pi. No signal is observed in the phi pi mass spectrum. Upper limits on the cross sections for Z(s) production at the 90% confidence level are determined. In addition, the cross sections of e(+)e(-) -> phi pi(+)pi(-) and e(+)e(-) -> phi pi(0)pi(0) at 2.125 GeV are measured to be (436.2 +/- 6.4 +/- 30.1) pb and (237.0 +/- 8.6 +/- 15.4) pb, respectively, where the first uncertainties are statistical and the second systematic.

  • Ablikim, M.
    et al.
    Andersson, Walter Ikegami
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Study of the D-0 -> K-mu(+)nu(mu) Dynamics and Test of Lepton Flavor Universality with D-0 -> K(-)l(+)nu(l) Decays2019In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 122, no 1, article id 011804Article in journal (Refereed)
    Abstract [en]

    Using e(+)e(-) annihilation data of 2.93 fb(-1) collected at center-of-mass energy root s = 3.773 GeV with the BESIII detector, we measure the absolute branching fraction of D-0 -> K-mu(+)nu(mu) with significantly improved precision: BD0 -> K-mu+nu mu = (3.413 +/- 0.019(stat) +/- 0.035(syst))%. Combining with our previous measurement of BD0 -> K-e+nu e, the ratio of the two branching fractions is determined to be BD0 -> K-mu+nu mu/BD0 -> K-e+nu e = 0.974 +/- 0.007(stat) +/- 0.012(syst), which agrees with the theoretical expectation of lepton flavor universality within the uncertainty. A study of the ratio of the two branching fractions in different four-momentumtransfer regions is also performed, and no evidence for lepton flavor universality violation is found with current statistics. Taking inputs from global fit in the standard model and lattice quantum chromodynamics separately, we determine f(+)(K)(0) = 0.7327 +/- 0.0039(stat) +/- 0.0030(syst) and vertical bar V-cs vertical bar = 0.955 +/- 0.005(stat) +/- 0.004(syst) +/- 0.024(LQCD).

  • Bartos, Annie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Vart är vi på väg?: En kvalitativ studie kring tjänstepersoners uppfattning om Uppsalas nya spårvägs sociala konsekvenser2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det sociala perspektivet finns på samtliga nivåer inom samhällsplanering idag men är trots det underprioriterat ekonomiska och ekologiska aspekter. Denna uppsats syftar till att undersöka hur sociala perspektiv inkluderas i omfattande infrastrukturinvesteringar genom att titta på exemplet spårvägen i Uppsala. Utifrån relevant teoretisk bakgrund kring social hållbarhet inom transportplanering väljs fem centrala analysbegrepp ut, i form av tillgänglighet, hälsa, jämlikhet, jämställdhet och påverkan på lokalsamhälle. Begreppen används sedan för att med semistrukturerade intervjuer undersöka hur berörda offentliga tjänstepersoner tror att spårvägen kan komma att påverka utifrån ett socialt perspektiv. Undersökningen visar att man inom projektet i många av fallen har en uppfattning om hur spårvägen skulle kunna påverka men att man inte arbetar med flertalet av de sociala perspektiven i en uttalad kontext. Uppfattningen kring begreppen skiljer sig dock mellan de olika respondenterna, vilket kan leda till en otydlighet som kan påverka både arbetet och resultatet. Det framkommer också att valet av spårväg har många mervärden som likvärdiga alternativ inte kan stå för, många som har en positiv påverkan på stadsutveckling och därför indirekt på flertalet sociala frågor.

  • Viker, Paulina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    ”Ibland är det svårt att följa rekommendationerna”: En studie om Vaxholms kommuns klimatanpassningsarbete och juridiska ansvar vid detaljplaneläggning med hänsyn till översvämningsrisker2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Idag detaljplaneläggs och bebyggs alltmer i kustområden eftersom det är attraktivt att bo intill vatten. Dessa områden riskerar att drabbas hårt av framtida havsnivåhöjning och översvämningar. Skadekostnader för bebyggelse i klimatutsatta områden har ökat den senaste tiden. Denna studie fokuserar på hur kustkommunen Vaxholm klimatanpassar med hänsyn till översvämningsrisker vid ny detaljplaneläggning för ny bebyggelse respektive befintlig bebyggelse vid äldre detaljplaner. Likaså studeras kommunens hantering och förståelse av sitt juridiska ansvar gällande klimatanpassning vid nya respektive äldre detaljplaner. En aspekt av studien är att förstå om och hur kommunen påverkats av Länsförsäkringars beslut att inte längre teckna försäkringar vid nybyggnationer i klimatutsatta riskområden. Genom en fallstudie och kvalitativa intervjuer erhölls kunskap kring kommunens samt Länsförsäkringars klimatanpassningsarbete och vem som bär det juridiska ansvaret för översvämningsskador. En kvalitativ innehållsanalys kompletterade intervjumaterialet. Resultatet visar att kommunen enbart klimatanpassar och har ett juridiskt ansvar vid ny detaljplaneläggning eftersom det endast är nya detaljplaner som omfattas av lagstiftningen. Kommunens skadeståndsansvar påverkas av Länsförsäkringars beslut genom att det finns en risk att fastighetsägare börjar rikta skadeståndsanspråk mot kommunen vid översvämningsskador, då fastighetsägare inte längre kan få ut pengar via försäkringsbolaget. Sannolikt kommer Vaxholms kommun i framtiden bli mer mån om att klimatanpassa vid ny detaljplaneläggning.

  • Garousi, Javad
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Lindbo, Sarah
    KTH Royal Inst Technol, Dept Prot Technol, SE-10691 Stockholm, Sweden.
    Borin, Jesper
    KTH Royal Inst Technol, Dept Prot Technol, SE-10691 Stockholm, Sweden.
    von Witting, Emma
    KTH Royal Inst Technol, Dept Prot Technol, SE-10691 Stockholm, Sweden.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Oroujeni, Maryam
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Buijs, Jos
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Hober, Sophia
    KTH Royal Inst Technol, Dept Prot Technol, SE-10691 Stockholm, Sweden.
    Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours2019In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 134, p. 37-48Article in journal (Refereed)
    Abstract [en]

    ADAPTs are small engineered non-immunoglobulin scaffold proteins, which have demonstrated very promising features as vectors for radionuclide tumour targeting. Radionuclide imaging of human epidermal growth factor 2 (HER2) expression in vivo might be used for stratification of patients for HER2-targeting therapies. ADAPT6, which specifically binds to HER2, has earlier been shown to have very promising features for in vivo targeting of HER2 expressing tumours. In this study we tested the hypothesis that dimerization of ADAPT6 would increase the apparent affinity to HER2 and accordingly improve tumour targeting. To find an optimal molecular design of dimers, a series of ADAPT dimers with different linkers, -SSSG- (DiADAPT6L1), -(SSSG)(2)- (DiADAPT6L2), and -(SSSG)(3)- (DiADAPT6L3) was evaluated. Dimers in combination with optimal linker lengths demonstrated increased apparent affinity to HER2. The best variants, DiADAPT6L2 and DiADAPT6L3 were site-specifically labelled with In-111 and I-125, and compared with a monomeric ADAPT6 in mice bearing HER2-expressing tumours. Despite higher affinity, both dimers had lower tumour uptake and lower tumour-to-organ ratios compared to the monomer. We conclude that improved affinity of a dimeric form of ADAPT does not compensate the disadvantage of increased size. Therefore, increase of affinity should be obtained by affinity maturation and not by dimerization.

  • Ahmad, Shafqat
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Ctr Lipid Metabol, 900 Commonwealth Ave, Boston, MA 02215 USA;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02215 USA.
    Moorthy, M. Vinayaga
    Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Ctr Lipid Metabol, 900 Commonwealth Ave, Boston, MA 02215 USA.
    Demler, Olga, V
    Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02215 USA.
    Hu, Frank B.
    Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02215 USA.
    Ridker, Paul M.
    Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02215 USA.
    Chasman, Daniel, I
    Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA.
    Mora, Samia
    Harvard Med Sch, Brigham & Womens Hosp, Prevent Med Div, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Ctr Lipid Metabol, 900 Commonwealth Ave, Boston, MA 02215 USA;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02215 USA.
    Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean Diet2018In: JAMA NETWORK OPEN, ISSN 2574-3805, Vol. 1, no 8, article id e185708Article in journal (Refereed)
    Abstract [en]

    IMPORTANCE Higher Mediterranean diet (MED) intake has been associated with lower risk of cardiovascular disease (CVD), but limited data are available about the underlying molecular mechanisms of this inverse disease association in human populations.

    OBJECTIVE To better characterize the relative contribution of traditional and novel factors to the MED-related risk reduction in CVD events in a US population.

    DESIGN, SETTING, AND PARTICIPANTS Using a prospective cohort design, baseline MED intake was assessed in 25 994 initially healthy US women in theWomen's Health Study who were followed up to 12 years. Potential mediating effects of a panel of 40 biomarkers were evaluated, including lipids, lipoproteins, apolipoproteins, inflammation, glucose metabolism and insulin resistance, branched-chain amino acids, small-molecule metabolites, and clinical factors. Baseline study information and samples were collected between April 30, 1993, and January 24, 1996. Analyses were conducted between August 1, 2017, and October 30, 2018.

    EXPOSURES Intake of MED is a 9-category measure of adherence to a Mediterranean dietary pattern. Participants were categorized into 3 levels based on their adherence to the MED.

    MAIN OUTCOMES AND MEASURES Incident CVD confirmed through medical records and the proportion of CVD risk reduction explained by mediators.

    RESULTS Among 25 994women (mean [SD] age, 54.7 [7.1] years), those with low, middle, and upper MED intakes composed 39.0%, 36.2%, and 24.8% of the study population and experienced 428 (4.2%), 356 (3.8%), and 246 (3.8%) incident CVD events, respectively. Compared with the reference group who had low MED intake, CVD risk reductions were observed for the middle and upper groups, with respective HRs of 0.77 (95% CI, 0.67-0.90) and 0.72 (95% CI, 0.61-0.86) (P for trend < .001). The largest mediators of the CVD risk reduction of MED intake were biomarkers of inflammation (accounting for 29.2% of the MED-CVD association), glucose metabolism and insulin resistance (27.9%), and body mass index (27.3%), followed by blood pressure (26.6%), traditional lipids (26.0%), high-density lipoprotein measures (24.0%) or very low-density lipoprotein measures (20.8%), with lesser contributions from low-density lipoproteins (13.0%), branched-chain amino acids (13.6%), apolipoproteins (6.5%), or other small-molecule metabolites (5.8%).

    CONCLUSIONS AND RELEVANCE In this study, higher MED intake was associated with approximately one-fourth relative risk reduction in CVD events, which could be explained in part by known risk factors, both traditional and novel.

  • Artmark, Ella
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Ord och matematiska symboler: En jämförelse av språket i två läromedel i matematik, avsedda för årskurs ett2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Broqvist, Moa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Den moderna skamstocken?: En diskursiv jämförelse mellan skamstraff och namngivningar kopplade till #metoo2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In the #metoo movement some men were named in accusations of sexual harassment or sexual abuse. Some people compared the naming to a mob society and that was the inspiration behind this essay. The aim of this essay is to compare the namings linked to #metoo with shame punishment when it was used as a punishment method by the Swedish judicial system. The theoretical perspectives used in this study are Chantal Mouffe and Ernesto Laclau’s discourse theory and Michel Foucault’s theories about punishment and discipline. The methods used to collect the empirical material are netnography, where some discussion threads have been studied, archive studies and a survey. The intention was that there should have been more material from archives used, but since it turned out to be difficult within this time frame, the information was instead mostly found in previous studies and other literature. The material showed that there are some similarities between the naming and shame punishment, but there are also aspects that make them differ. The similarities are that they both can be seen as punishment, the shame punishment was also much about sexual offenses, shame is an aim and they have both received critic by those who think it is a cruel thing to do to someone. The differences are that the body is not a part of the namings, the shame punishments were practiced by the juridical system and that it was easier to get out of a shame punishment if a person was rich. In addition men who broke the law against any sexual intercourse outside of marriage had it easier to avoid getting caught since they were not the ones getting pregnant. In #metoo money or gender was/is not a guarantee to escape being named and/or identified as a sex-offender.  

  • Blanken, T. C.
    et al.
    Cecconello, Marco
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Klimek, Iwona
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Wodniak, I
    Yadykin, Dimitry
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy.
    Dori, V
    Real-time plasma state monitoring and supervisory control on TCV2019In: Nuclear Fusion, ISSN 0029-5515, E-ISSN 1741-4326, Vol. 59, no 2, article id 026017Article in journal (Refereed)
    Abstract [en]

    In ITER and DEMO, various control objectives related to plasma control must be simultaneously achieved by the plasma control system (PCS), in both normal operation as well as off-normal conditions. The PCS must act on off-normal events and deviations from the target scenario, since certain sequences (chains) of events can precede disruptions. It is important that these decisions are made while maintaining a coherent prioritization between the real-time control tasks to ensure high-performance operation. In this paper, a generic architecture for task-based integrated plasma control is proposed. The architecture is characterized by the separation of state estimation, event detection, decisions and task execution among different algorithms, with standardized signal interfaces. Central to the architecture are a plasma state monitor and supervisory controller. In the plasma state monitor, discrete events in the continuous-valued plasma state arc modeled using finite state machines. This provides a high-level representation of the plasma state. The supervisory controller coordinates the execution of multiple plasma control tasks by assigning task priorities, based on the finite states of the plasma and the pulse schedule. These algorithms were implemented on the TCV digital control system and integrated with actuator resource management and existing state estimation algorithms and controllers. The plasma state monitor on TCV can track a multitude of plasma events, related to plasma current, rotating and locked neoclassical tearing modes, and position displacements. In TCV experiments on simultaneous control of plasma pressure, safety factor profile and NTMs using electron cyclotron heating (ECI I) and current drive (ECCD), the supervisory controller assigns priorities to the relevant control tasks. The tasks are then executed by feedback controllers and actuator allocation management. This work forms a significant step forward in the ongoing integration of control capabilities in experiments on TCV, in support of tokamak reactor operation.

  • Mazorchuk, Volodymyr
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Classification problems in 2-representation theory2017In: São Paulo Journal of Mathematical Sciences, ISSN 1982-6907, E-ISSN 2316-9028, Vol. 11, no 1, p. 1-22Article in journal (Refereed)
    Abstract [en]

    This article surveys recent advances and future challenges in the 2-representation theory of finitary 2-categories with a particular emphasis on problems related to classification of various classes of 2-representations.

  • Muleba, Joanna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    "Det är liksom något som skaver...": En etnologisk studie av erfarenheter och upplevelser av ett mellanförskap2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Granat, Paulina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    "Då kanske man till slut kan kalla sig konstnär": En etnologisk studie av kapital och strategi samt betydelsen av konsthögskoleutbildningar2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This essay studies the strategic practices of art students, in terms of establishing positions as legitimate artists, within the Swedish higher educational system. Through interviews with six art students, the study explores the opportunities, limitations and definitions of value that agents with different capital compositions experience within the artistic educational field. Through qualitative interviews and cultural analysis, the essay shows examples of how the studied individuals navigate their perceived positions within the artistic field, and with what means they attempt to establish their wanted positions within that field. The study shows that by applying the theoretical framework created by sociologist Pierre Bourdieu, the experiences of the studied individuals relate to a greater system of power distribution, which seemingly governs over means of influence within the artistic field. This system can be found reproduced through educational institutions, such as the Swedish art schools in question. Antagonistic attempts of re-forming this institutionally governed field seem only to be coming from individuals with positions of power in general society, which points to a power structure that obstructs any pretensions on the artistic field coming from agents outside of the artistic or social elite. This essay thereby encourages further study of the arguable freedom attributed to artistic practitioners, in light of the potential creative boundaries established through institutional power.

  • Ekeland Sjöberg, Kerstin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Berättelsen vi är och bär: om naturens betydelse för vem vi upplever oss vara2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Does our cultural background colour our perception of nature? And if so, can it be seen when asked about early childhood memories? These were some of the starting questions I was pondering over after a walk in the forest with 5 women from different continents. Even if we were about same age, it was quite clear that what we saw and how we perceived the surroundings differed.

    At this time, I got a book written by Bruno Latour and as his thought was intriguing, I wanted to test my understanding of his actor-network theory and search for traits that could explain the difference in our perception by following his advice. This was not as easy as it seemed.

    My material is based on interviews with three women in their 60´s and early 70´s done during October 2018. They told about their early childhood memory of nature. I used this material to follow the connections back in time and between actors of importance in their environs. I could also find trails that followed them until this day.

    I have also discussed different aspects of the use of narrative as a tool to make the reality understandable for the individual. How interpretation evolves during life to maintain the importance of one’s life in time and space. Words have the ability to imbed events in a bigger narrative and in that way let things be remembered for the future. How we react to events do depend on both cultural and biological factors and our interpretation of the situation is something that may have duration during our whole life. A tiny thing such as a blueberry can have a huge importance as one of the women told me.

    I found that a simple question revealed an astonishing amount of information that could be tracked down in time. Cultural tradition could be seen, and trails of family history were observable. Also, nature preferences turned out to have been established early. All three talked about the importance of their type of nature throughout their life, but what they preferred differed. What one of the women found preferable was totally indifferent for one of the others and the source was to be found in these important childhood memories.

    I have used research from several scientific disciplines and authors as Latour, Bell, Ellen, Frykman, Daun, Saltzman, Ulrich, Kaplan and others. The point of departure is ethnology, but other areas are visited during this study due to the fact that, as I argue, everything is connected, following Bruno Latour in his actor-network theory.

  • Olausson, Serafia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Det nya landet: En etnologisk studie av nyanländas berättande om sina upplevelser av Sverige2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study examines the narrative of newly arrived immigrants and how they express their experiences in Sweden with different expectations on them and their narrative. It focuses on individual stories told in interviews with five individuals who have come to Sweden from war-torn countries in the last three years. The narratives are primarily analyzed through Erving Goffman’s theories on self- presentation and Ulf Palmenfelt’s theories on how individuals are positioning themselves through their narratives. The study discusses the expectations from the person’s family, from the interviewer and the Swedish society. It shows that the narration is shifting depending on the audience. This paper investigates how newly arrived immigrants relate their narratives to position themselves based on the understanding of them as immigrants in a Swedish context. When telling about their experience to their families the narrative is changing, and it is primarily important for them to communicate their well-being in the new country. I have a big part in production of the empirical material, since I function as someone ’in-between’. I am a part of the Swedish community but also someone that the informants are deputing their story to. The narrative conveyed to me is both taking the Swedish audience into account, but also explaining how they feel when people are seeing them as immigrants. 

  • Widholm, Madelene
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    DEN FYSISKA DRAGNINGSKRAFTEN: En etnologisk studie av människors fysiska agerande gentemot kulturarvsföremål i slottsmiljöer2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna kandidatuppsats i etnologi har till syfte att utifrån ett etnologiskt perspektiv förstå den fysiska relation som kan uppstå mellan kulturhistoriska föremål och människor. Bakgrunden till denna studie är museum och slottsmiljöers behov av ”Var vänligen rör ej”-skyltar. Studien har utgått från Kungliga slottet i Stockholm där etnografiska insamlingsmetoder såsom semistrukturerade intervjuer och observationer har genomförts för att tillhandahålla materialet för undersökningen. Maurice Merleau-Pontys tankar om kroppens fenomenologi, teorier om fetishism samt approriering har används som analysverktyg för att tolka och förstå det insamlade materialet. Studiens resultat visar hur människor ger uttryck för en attraktion gentemot objekten. Detta kommer till uttryck genom att de antigen upplever ett behov av dokumentation alternativt ett specifikt rörelsemönster eller ett närmande. Det kulturhistoriska rummet kan även utgöra en fysisk dragningskraft likväl som specifika lösa föremål. Människor vill närma sig objekten för att komma åt det kollektiva värde som objektet har tillskrivits men agerandet kan även förstås som att det finnas en tidigare omedveten kroppslig erfarenhet gentemot vad man tror är ett liknande föremål. Agerandet gentemot objekten kan även tolkas som ett uttryck för ett behov av appropriation. Studiens resultat bidrar därför med kunskap och insikt om relationen mellan kulturarvsföremål och människor. Hur och varför denna relation kan uttrycka sig i ett fysiskt agerande.

  • Price, Neil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Distant vikings: a manifesto2018In: Acta Archaeologica, ISSN 0065-101X, E-ISSN 1600-0390, Vol. 89, no 1, p. 113-132Article in journal (Refereed)
    Abstract [en]

    This paper addresses some contemporary challenges in approaching the Viking Age, specifically the need for new interpretive models that we can bring to bear on its material culture, ideally drawn from cross-cultural, comparative analyses across time and place. A range of potential case studies is presented here from the island states of Oceania, across the broad socio-cultural networks of the Pacific. By looking at familiar Scandinavian sites and finds through a different lens, we can view them afresh and arrive at new understandings of this critical period of Northern history by comparison with these 'distant Vikings'.

  • Doroszko, Milena
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Univ Turku, Inst Biomed, Turku, Finland.
    Chrusciel, Marcin
    Univ Turku, Inst Biomed, Turku, Finland.
    Stelmaszewska, Joanna
    Med Univ Bialystok, Dept Reprod & Gynecol Endocrinol, Bialystok, Poland.
    Slezak, Tomasz
    Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA.
    Anisimowicz, Slawomir
    Ctr Gynecol & Reprod Endocrinol Artemida, Bialystok, Poland.
    Plöckinger, Ursula
    Charite Univ Med Berlin, Interdisciplinary Ctr Metab Endocrinol Diabet & M, Berlin, Germany.
    Quinkler, Marcus
    Endocrinol Charlottenburg, Berlin, Germany;Charite Univ Med Berlin, Charite Campus Mitte, Dept Clin Endocrinol, Berlin, Germany.
    Bonomi, Marco
    Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
    Wolczynski, Slawomir
    Med Univ Bialystok, Dept Reprod & Gynecol Endocrinol, Bialystok, Poland.
    Huhtaniemi, Ilpo
    Univ Turku, Inst Biomed, Turku, Finland;Imperial Coll London, Fac Med, Dept Surg & Canc, London, England.
    Toppari, Jorma
    Univ Turku, Inst Biomed, Turku, Finland;Turku Univ Hosp, Dept Pediat, Turku, Finland.
    Rahman, Nafis A.
    Univ Turku, Inst Biomed, Turku, Finland;Med Univ Bialystok, Dept Reprod & Gynecol Endocrinol, Bialystok, Poland.
    GnRH antagonist treatment of malignant adrenocortical tumors2019In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 26, no 1, p. 103-117Article in journal (Refereed)
    Abstract [en]

    Aberrantly expressed G protein-coupled receptors in tumors are considered as potential therapeutic targets. We analyzed the expressions of receptors of gonadotropin-releasing hormone (GNRHR), luteinizing hormone/chorionic gonadotropin (LHCGR) and follicle-stimulating hormone (FSHR) in human adrenocortical carcinomas and assessed their response to GnRH antagonist therapy. We further studied the effects of the GnRH antagonist cetrorelix acetate (CTX) on cultured adrenocortical tumor (ACT) cells (mouse C alpha 1 and Y-1, and human H295R), and in vivo in transgenic mice (SV40 T-antigen expression under inhibin a promoter) bearing Lhcgr and Gnrhr in ACT. Both models were treated with control (CT), CTX, human chorionic gonadotropin (hCG) or CTX+hCG, and their growth and transcriptional changes were analyzed. In situ hybridization and qPCR analysis of human adrenocortical carcinomas (n = 11-13) showed expression of GNRHR in 54/73%, LHCGR in 77/100% and FSHR in 0%, respectively. CTX treatment in vitro decreased cell viability and proliferation, and increased caspase 3/7 activity in all treated cells. In vivo, CTX and CTX+hCG (but not hCG alone) decreased ACT weights and serum LH and progesterone concentrations. CTX treatment downregulated the tumor markers Lhcgr and Gata4. Upregulated genes included Grb10, Rerg, Nfatc and Gnas, all recently found to be abundantly expressed in healthy adrenal vs ACT. Our data suggest that CTX treatment may improve the therapy of human adrenocortical carcinomas by direct action on GNRHR-positive cancer cells inducing apoptosis and/or reducing gonadotropin release, directing tumor cells towards a healthy adrenal gene expression profile.

  • Adl, Sina M.
    et al.
    Univ Saskatchewan, Dept Soil Sci, Coll Agr & Bioresources, 51 Campus Dr, Saskatoon, SK S7N 5A8, Canada.
    Bass, David
    Nat Hist Museum, Dept Life Sci, Cromwell Rd, London SW7 5BD, England;CEFAS, Barrack Rd, Weymouth DT4 8UB, Dorset, England.
    Lane, Christopher E.
    Univ Rhode Isl, Dept Biol Sci, Kingston, RI 02881 USA.
    Lukes, Julius
    Czech Acad Sci, Biol Ctr, Inst Parasitol, Ceske Budejovice 37005, Czech Republic;Univ South Bohemia, Fac Sci, Ceske Budejovice 37005, Czech Republic.
    Schoch, Conrad L.
    Natl Inst Biotechnol Informat, Natl Lib Med, NIH, Bethesda, MD 20892 USA.
    Smirnov, Alexey
    St Petersburg State Univ, Fac Biol, Dept Invertebrate Zool, St Petersburg 199034, Russia.
    Agatha, Sabine
    Univ Salzburg, Dept Biosci, Hellbrunnerstr 34, A-5020 Salzburg, Austria.
    Berney, Cedric
    CNRS, UMR 7144 AD2M, Grp Evolut Protistes & Ecosyst Pelag, Stn Biol Roscoff, Pl Georges Teissier, F-29680 Roscoff, France.
    Brown, Matthew W.
    Mississippi State Univ, Dept Biol Sci, Starkville, MS 39762 USA;Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA.
    Burki, Fabien
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Cárdenas, Paco
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Cepicka, Ivan
    Charles Univ Prague, Dept Zool, Fac Sci, Vinicna 7, CR-12844 Prague, Czech Republic.
    Chistyakova, Lyudmila
    St Petersburg State Univ, Core Facil Ctr Culture Collect Microorganisms, St Petersburg 198504, Russia.
    del Campo, Javier
    CSIC, Inst Ciencies Mar, Passeig Maritim Barceloneta 37-49, E-08003 Barcelona, Catalonia, Spain.
    Dunthorn, Micah
    Univ Kaiserslautern, Dept Ecol, Erwin Schroedinger St, D-67663 Kaiserslautern, Germany;Univ Duisburg Essen, Dept Eukaryot Microbiol, Univ Str 5, D-45141 Essen, Germany.
    Edvardsen, Bente
    Univ Oslo, Dept Biosci, POB 1066 Blindern, N-0316 Oslo, Norway.
    Eglit, Yana
    Dalhousie Univ, Dept Biol, Halifax B3H 4R2, NS, Canada.
    Guillou, Laure
    Univ Paris 06, Sorbonne Univ, Paris 6, CNRS,UMR 7144 AD2M,Stn Biol Roscoff, Pl Georges Teissier,,CS90074, F-29688 Roscoff, France.
    Hampl, Vladimir
    Charles Univ Prague, Dept Parasitol, Fac Sci, BIOCEV, Prumyslov 595, Vestec 25242, Czech Republic.
    Heiss, Aaron A.
    Amer Museum Nat Hist, Dept Invertebrate Zool, New York, NY 10024 USA.
    Hoppenrath, Mona
    DZMB German Ctr Marine Biodivers Res, D-26382 Wilhelmshaven, Germany.
    James, Timothy Y.
    Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
    Karnkowska, Anna
    Univ Warsaw, Dept Mol Phylogenet & Evolut, PL-02089 Warsaw, Poland.
    Karpov, Sergey
    St Petersburg State Univ, Fac Biol, Dept Invertebrate Zool, St Petersburg 199034, Russia;RAS, Lab Parasit Worms & Protistol, Zool Inst, St Petersburg 199034, Russia.
    Kim, Eunsoo
    Amer Museum Nat Hist, Dept Invertebrate Zool, New York, NY 10024 USA.
    Kolisko, Martin
    Czech Acad Sci, Biol Ctr, Inst Parasitol, Ceske Budejovice 37005, Czech Republic.
    Kudryavtsev, Alexander
    St Petersburg State Univ, Fac Biol, Dept Invertebrate Zool, St Petersburg 199034, Russia;RAS, Lab Parasit Worms & Protistol, Zool Inst, St Petersburg 199034, Russia.
    Lahr, Daniel J. G.
    Univ Sao Paulo, Dept Zool, Inst Biosci, Matao Travessa 14 Cidade Univ, BR-05508090 Sao Paulo, SP, Brazil.
    Lara, Enrique
    Univ Neuchatel, Lab Soil Biodivers, Rue Emile Argand 11, CH-2000 Neuchatel, Switzerland;CSIC, Real Jardim Bot,Plaza Murillo 2, E-28014 Madrid, Spain.
    Le Gall, Line
    Sorbonne Univ, Museum Natl Hist Nat, Inst Systemat Evolut Biodiversit, 57 Rue Cuvier,CP 39, F-75005 Paris, France.
    Lynn, Denis H.
    Univ Guelph, Dept Integrat Biol, Summerlee Sci Complex, Guelph, ON N1G 2W1, Canada;Univ British Columbia, Dept Zool, 4200-6270 Univ Blvd, Vancouver, BC V6T 1Z4, Canada.
    Mann, David G.
    Royal Bot Garden, Edinburgh EH3 5LR, Midlothian, Scotland;Inst Agrifood Res & Technol, C Poble Nou Km 5-5, E-43540 San Carlos de la Rapita, Spain.
    Massana, Ramon
    CSIC, Inst Ciencies Mar, Passeig Maritim Barceloneta 37-49, E-08003 Barcelona, Catalonia, Spain.
    Mitchell, Edward A. D.
    Univ Neuchatel, Lab Soil Biodivers, Rue Emile Argand 11, CH-2000 Neuchatel, Switzerland;Jardin Bot Neuchatel,Chemin Perthuis du Salut 58, CH-2000 Neuchatel, Switzerland.
    Morrow, Christine
    Natl Museums Northern Ireland, Dept Nat Sci, 153 Bangor Rd, Holywood BT18 0EU, England.
    Park, Jong Soo
    Kyungpook Natl Univ, Sch Earth Syst Sci, Dept Oceanog, Daegu, South Korea;Kyungpook Natl Univ, Sch Earth Syst Sci, Kyungpook Inst Oceanog, Daegu, South Korea.
    Pawlowski, Jan W.
    Univ Geneva, Dept Genet & Evolut, CH-1211 Geneva 4, Switzerland.
    Powell, Martha J.
    Univ Alabama, Dept Biol Sci, Tuscaloosa, AL 35487 USA.
    Richter, Daniel J.
    Univ Pompeu Fabra, CSIC, Inst Biol Evolut, Passeig Maritim Barceloneta 37-49, Barcelona 08003, Spain.
    Rueckert, Sonja
    Edinburgh Napier Univ, Sch Appl Sci, Edinburgh EH11 4BN, Midlothian, Scotland.
    Shadwick, Lora
    Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA.
    Shimano, Satoshi
    Hosei Univ, Sci Res Ctr, Chiyoda Ku, 2-17-1 Fujimi, Tokyo, Japan.
    Spiegel, Frederick W.
    Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA.
    Torruella, Guifre
    Univ Paris XI, Lab Evolut & Systemat, F-91405 Orsay, France.
    Youssef, Noha
    Oklahoma State Univ, Dept Microbiol & Mol Genet, Stillwater, OK 74074 USA.
    Zlatogursky, Vasily V.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. St Petersburg State Univ, Fac Biol, Dept Invertebrate Zool, St Petersburg 199034, Russia.
    Zhang, Qianqian
    Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China.
    Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes2019In: Journal of Eukaryotic Microbiology, ISSN 1066-5234, E-ISSN 1550-7408, Vol. 66, no 1, p. 4-119Article in journal (Refereed)
    Abstract [en]

    This revision of the classification of eukaryotes follows that of Adl et al., 2012 [J. Euk. Microbiol. 59(5)] and retains an emphasis on protists. Changes since have improved the resolution of many nodes in phylogenetic analyses. For some clades even families are being clearly resolved. As we had predicted, environmental sampling in the intervening years has massively increased the genetic information at hand. Consequently, we have discovered novel clades, exciting new genera and uncovered a massive species level diversity beyond the morphological species descriptions. Several clades known from environmental samples only have now found their home. Sampling soils, deeper marine waters and the deep sea will continue to fill us with surprises. The main changes in this revision are the confirmation that eukaryotes form at least two domains, the loss of monophyly in the Excavata, robust support for the Haptista and Cryptista. We provide suggested primer sets for DNA sequences from environmental samples that are effective for each clade. We have provided a guide to trophic functional guilds in an appendix, to facilitate the interpretation of environmental samples, and a standardized taxonomic guide for East Asian users.

  • Eklund, Isabelle
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Eklund, Rebecca
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Likhet eller svar?: En kvantitativ studie om elevers uppfattningar om likhetstecknet2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsens syfte är att bidra med kunskap om hur elever i årskurs tre uppfattar likhetstecknets innebörd. För att kunna uppfylla syftet med uppsatsen ställde vi tre forskningsfrågor: hur uppfattar eleverna likhetstecknets betydelse i olika kontexter?, Hur ser ett antal svenska elevers i prestationer i algebra ut jämfört med ett antal sydkoreanska elever?, samt vilka olika resonemangsvariationer ser vi i elevernas olika svar? I den första forskningsfrågan avser kontexter likhetstecknet i tre olika moment: i) Ekvationers strukturer (inkluderar även relationella resonemang uppgifter), t.ex. om 22+15=15+22 är sant eller falskt, ii) Definition av likhetstecknet, t.ex. beskriv innebörden av likhetstecknet, iii) Öppna ekvationer, t.ex. vilket är det okända talet i den givna ekvationen?

     

    Vi valde att genomföra en kvantitativ studie med hjälp av ett matematiktest. 72 elever i årskurs tre genomförde testet i vår studie. Med hjälp av en så kallad konstruktionskarta kategoriserade vi var eleverna befann sig kunskapsmässigt i sin förståelse för likhetstecknets innebörd.Blanton, Stephens, Knuth, Murphy Gardiner, Isler och Kim (2015)  har kategoriserat algebran i fem olika kategorier så kallade ”big ideas". Med hjälp av ”big ideas” kunde vi få en översiktlig bild över hur eleverna i undersökningen uppfattar likhetstecknet i olika algebraiska kontexter det vill säga i de fem olika kategorierna. För att kunna jämföra hur eleverna i vår undersökning presterade på matematiktestet med en internationell forskningsstudie valde vi en forskningsstudie som genomförts i Sydkorea, där man har använt sig av samma matematiktest som eleverna i vår undersökning har genomfört. Således jämförde vi elevernas prestationer i vår undersökning med de sydkoreanska eleverna i årskurs tre prestationer på samma matematiktest.

     

    Resultatet visade att eleverna uppfattar likhetstecknet olika beroende på vilken kontext symbolen presenteras i. Majoriteten av eleverna missuppfattar likhetstecknet och ser det som signal till svaret på frågan. Eleverna presterar lägst i det område inom algebran som representerar generaliserad aritmetik som innefattar strukturer, relationer och mönster inom aritmetiken. Eleverna i studien har en lägre relationell förmåga det vill säga har lägre förmåga att se strukturer och relationer än de sydkoreanska eleverna men ligger i övrigt på samma kunskapsnivå inom detta test.

  • Molund, Jakob
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Järnkrok, Ida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Relationskommunikation över landsgränserna: - En studie om relation, kommunikation och strategi i ett litet samhälle med en stor närvaro2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Research ProblemToday, the great focus is on the organization’s place on different digital platforms as well as in the more traditional print world. A lot of research has been done on the factors that are included into an organization’s success; product quality, pricing, visitor satisfaction and availability, to name a few. However, a direct correlation has been identified between a company’s relationships and its success. Social media provides new opportunities for organizations to create and maintain relationships with individuals. However, previous research does not appear to have its focus on the relationship-building work made by destination organizations based on the growth of digitization. Purpose and research question The purpose of the paper is to investigate the Norwegian company Flåm AS communicative relation-building, before and after they were digitized, as well as looking at how their relationship strategy has changed since the digitization process. What does Flåm AS relationship-building work look like? • What has the digitization process looked like? • What characterized the relationship-building work before the digitization process? • What does the relationship-building work look like after the digitization process? MethodUsing a qualitative approach, this thesis has conducted three semi-structured telephone interviews. The respondents are all employed by Flåm AS. In addition to these, a qualitative analysis has been carried out, using documents belonging to the organization. Results There are significant differences to be observed in the relationship-building work done by Flåm AS before and after the organization was digitized. The differences are not only to be found in their distribution strategies but also in the type of recipient the organization has. With the changes in the behavior of visitors and their approach to travel, the organization has adapted its strategies in communicative relationship-building work. Research grants This paper offers an insight into how an organization has adapted its strategies to meet the perceptions and expectations of potential visitors. Furthermore, it highlights the importance of different types of relationship-building work done by an organization.

  • Landgren, Minda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Josefsson, Evelina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Johnsson, Frida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Systembolaget och unga: En studie om hur systembolagets reklamfilmers budskap tas emot2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract
 

    Title:Systembolaget och unga - En studie om hur Systembolagets reklamfilmers budskap tas emot 

    Authors: Frida Johnsson, Evelina Josefsson, Minda Landgren 

    Aim: The aim with this essay is to analyze how the target audience 18-19-year olds, and consumers of Systembolaget, the target audience of 20- 25-year olds, are affected by two specific commercials named “Systrar” and “Bröder” and furthermore examine whether the commercials have a deterrent effect on the audience or not. The questions the essay answers are “How do 18-19-year olds perceive that they are affected by the campaign films?” and “How do 20-25-year olds perceive that they are affected by the campaign films?”. This essay uses the methods qualitative analysis and focus group interviewand is based on the theoryEncoding/Decoding. In conclusion Systembolaget uses emotions to convey their message. To the audiences the commercials are not as deterrent as one might first imagine.  

    Number of pages: 56

    Course: Media and Communication studies C

    Department: Department of Informatics and Media

    University: Uppsala University

    Period: Autumn 2018

    Tutor: Per Gunnar Holmlöv

    Keywords: Ungdomar, Systembolaget, Alkohol, Reklamfilm, Encoding/Decoding, Teman, Koder, Kontext 

     

  • Fabrelius, Philip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Vinnare eller förlorare?: Aktieägarnas avvikelseavkastning i det köpande bolaget2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker hur ett tillkännagivande om ett företagsförvärv påverkar det köpande bolagets avkastning på den svenska aktiemarknaden. För att mäta avvikelseavkastningen på dagen för tillkännagivandet används en klassisk eventstudie. Studien innehåller 86 observationer där hälften av förvärven sker inom Sverige och hälften sker utanför Sveriges gränser. Resultaten för inhemska och internationella köp jämförs för att se om det finns någon skillnad mellan båda förvärvstyperna. En multivariat analys genomförs för att undersöka förklaringsgraden på avvikelseavkastningen.  

  • Hedefalk, Maria
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Teaching for sustainability2019In: NERA 2019: Education in a globalized world, 2019Conference paper (Other academic)
  • Andersson, Linnea
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Kartläggning av möjligheten att återanvända takdagvatten för att minska dricksvattenförbrukningen2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Drinking water is vital for our daily life. With climate change comes increasing temperatures and more extreme weather which can jeopardize our access to drinking water. One way to reduce our drinking water consumption is to collect rainwater and use it for processes which have lower quality demands than drinking water. Swedavia is constantly working on making their airports more environmentally friendly and as a part of this reducing the drinking water consumption. This project examines how water can be collected at Swedavia’s airports. The project results should be of intent to all of Swedavia’s airports even if the project is performed at Stockholm Arlanda Airport.

    In this project the water quality from five different types roofs has been studied. The different kind of roofs were chosen based on previous studies where pollutants in roof-harvested rainwater were studied. Other aspects such as location on the airports were also considered. Samplings were collected at two different occasions where water was collected from the different roofs. One sample of clean rainwater was collected as a reference. Five nutrients, dissolved organic matter, suspended matter and six heavy metals were analyzed.

    Three of the roofs gave water with high values that exceeded the quality limits. The samples from the green roof showed high levels of phosphorus and dissolved organic matter. The steel roof gave high levels of zink which may origin from its zink coating. The roof with PVC plastic also gave high levels of zink, but not as high as the steel roof. The roof with FPO plastic, a more environmentally friendly plastic, and the roof with roof paper gave low values and did not exceed any quality limits. The reference sample of clean rainwater gave high values of suspended matter at the second occasion and high values of lead that exceeded the quality limits.

    The conclusions of this project are that roof-harvested rainwater from green roofs, steel roofs and roofs with PVC plastic may exceed quality limits which makes them less suitable for collecting and re-use. The results are based on the two sampling occasions which means that sampling at more occations needs to be done to make definitive conclusions. The roofs with FPO plastic and roof paper do not exceed any quality limits and can therefore, according to the analyzed parameters, be suitable for collecting rainwater. It is important to note that to be able to reuse the water and guarantee that the quality of the water does not exceed any quality limits more parameters should be analyzed.

  • Bennett, J. M.
    et al.
    Martin Luther Univ Halle Wittenberg, Inst Biol, Kirchtor 1, D-06108 Halle, Saale, Germany;German Ctr Integrat Biodivers Res iDiv, Deutsch Pl 5e, D-04103 Leipzig, Germany.
    Steets, J. A.
    Oklahoma State Univ, Dept Plant Biol Ecol & Evolut, Stillwater, OK 74078 USA;Illuminat Works, 2689 Commons Blvd Suite 120, Beavercreek, OH 45431 USA.
    Burns, J. H.
    German Ctr Integrat Biodivers Res iDiv, Deutsch Pl 5e, D-04103 Leipzig, Germany;Case Western Reserve Univ, Dept Biol, Cleveland, OH 44106 USA.
    Durka, W.
    UFZ Helmholtz Ctr Environm Res, Dept Community Ecol, Theodor Lieser Str 4, D-06120 Halle, Saale, Germany.
    Vamosi, J. C.
    Univ Calgary, Dept Biol Sci, Calgary, AB, Canada.
    Arceo-Gómez, G.
    Eastern Tennessee State Univ, Dept Biol Sci, Johnson City, TN USA.
    Burd, M.
    Monash Univ, Sch Biol Sci, Melbourne, Vic 3800, Australia.
    Burkle, L. A.
    Montana State Univ, Dept Ecol, Bozeman, MT 59715 USA.
    Ellis, A. G.
    Univ Stellenbosch, Dept Bot & Zool, Private Bag X1, ZA-7602 Matieland, South Africa.
    Freitas, L.
    Inst Pesquisas Jardim Bot Rio de Janeiro, Rua Pacheco Leao 915, BR-22460030 Rio De Janeiro, RJ, Brazil.
    Li, J.
    Taizhou Univ, Taizhou City, Zhejiang, Peoples R China.
    Rodger, J. G.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Univ Stellenbosch, Dept Bot & Zool, Private Bag X1, ZA-7602 Matieland, South Africa.
    Wolowski, M.
    Univ Fed Alfenas, Inst Nat Sci, Gabriel Monteiro da Silva St 700, BR-37130001 Alfenas, MG, Brazil.
    Xia, J.
    South Cent Univ Nationalities, Coll Life Sci, Wuhan, Hubei, Peoples R China.
    Ashman, T-L
    Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA.
    Knight, T. M.
    Martin Luther Univ Halle Wittenberg, Inst Biol, Kirchtor 1, D-06108 Halle, Saale, Germany;German Ctr Integrat Biodivers Res iDiv, Deutsch Pl 5e, D-04103 Leipzig, Germany;UFZ Helmholtz Ctr Environm Res, Dept Community Ecol, Theodor Lieser Str 4, D-06120 Halle, Saale, Germany.
    Publisher Correction: GloPL, a global data base on pollen limitation of plant reproduction2019In: Scientific Data, E-ISSN 2052-4463, Vol. 6, article id 2Article in journal (Refereed)
  • Gunnarsson, Maja
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Om att minska fysiska och mentala avstånd: Lokalisering och relationsbyggande hos andelsjordbruk i Sverige2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Utifrån de globala utmaningarna och dystra framtidsprognoserna vi möter idag så utforskas hållbara lösningar. Andelsjordbruk är ett koncept för ett hållbart, gemenskapsbaserat jordbruk som rör sig i ett gränsland mellan att vara företagsmodell och utopisk framtidsvision, och som får allt större spridning i Sverige. Kärnan i konceptet är att återskapa lokala band och minska avstånd mellan konsument och producent. Syftet med denna studie är att få en ökad förståelse för hur andelsjordbrukens lokalisering ger förutsättningarna för verksamhetens upplägg och marknadsföring, med särskild fokus på dynamiken mellan jordbrukare och andelsägare som en central komponent i andelsjordbruks-modellen. Denna undersökning genomfördes som intervjustudie med ett urval andelsjordbrukare i Sverige. Resultaten visar att graden av fysiska interaktioner mellan jordbruken och konsumenterna oavsett fysiskt avstånd inte överstiger en viss nivå då konsumenternas intresse men framför allt tid är begränsad. Det framkommer i resultaten att lokaliseringen däremot är viktig ur ett marknadsföringsperspektiv med hänsyn till kundunderlaget. Förutsättningarna för att starta ett andelsjordbruk skiljer således mellan platser och verksamheter måste hitta strategier för att anpassa sig till dem lokala förutsättningarna.

  • Ljungström, Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    (Klimat)förändringar i valrörelsen: En kvantitativ och kvalitativ innehållsanalys av svenska mediers klimatbevakning inför valet 2010 och 20182019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien är att jämföra hur klimatbevakningen i svenska medier förändrats över tid. I en kvantitativ innehållsanalys analyseras 303 artiklar från Sveriges två största betalda dagstidningar, Dagens Nyheter och Svenska Dagbladet. Artiklarna publicerades mellan 9 augusti – 9 september 2018 och 19 augusti – 19 september 2010. Den kvantitativa delen av studien kompletteras med en kvalitativ innehållsanalys, där fem krönikor från respektive år djupanalyseras. Både den kvalitativa och kvantitativa analysen baseras på teorier om nyhetsvärdering och framing. Genom den kvalitativa analysen undersöks vilka likheter och skillnader som finns i klimatbevakningen gällande psykologiska klimatbarriärer, med fokus på klimatförnekelse, distansering och katastrofvinkling. Studiens resultat visar att klimatet nämndes i 216 artiklar 2018 och i 87 stycken 2010, vilket innebär en ökning med 148 procent. Klimatet var dessutom huvudämne för fler artiklar 2018 än 2010. Klimatbevakningen skedde också på ett bredare plan 2018, genom att innefatta fler vetenskapliga discipliner, fler tidningssektioner och fler sakfrågor än tidigare. Klimatförnekelse förekom sällan, men klimatrapporteringen tenderade att röra kulturellt eller geografiskt avlägsna platser. I krönikorna från 2018 överbyggs delvis distansen, samtidigt som texterna har fler lösningsorienterade drag. Slutsatsen är att klimatfrågan fick ett större genomslag i svenska medier 2018 än 2010, både gällande utrymme och innehåll.

  • Ekbom, Malcolm
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Sjödin, Simon
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Avknoppningar på den svenska marknaden: Värdeskapande på kort och lång sikt2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker det kortsiktiga och långsiktiga värdeskapandet av 28 respektive 26 avknoppningar på den svenska marknaden utförda mellan januari 2000 och juni 2017. Undersökningen finner att moderbolagen i genomsnitt genererar en signifikant positiv kumulativ abnorm avkastning över en tredagarsperiod vid annonsering om 4,1%. Studien undersöker även huruvida det finns en skillnad i kortsiktig abnorm avkastning beroende på graden av informationsasymmetri hos moderbolaget samt om moderbolaget knoppar av en relativt stor eller relativt liten del av verksamheten. Ingen signifikant skillnad finnes i abnorm avkastning för någon av variablerna. Den genomsnittliga abnorma avkastningen för de avknoppade bolagen upp till ett år efter avknoppningen uppgår till 30,9% och 32,7% justerat enlig Fama och Frenchs (1993) trefaktormodell respektive Carharts (1997) fyrfaktormodell. Moderbolagen finner studien inte visa någon signifikant abnorm avkastning över samma tidsperiod.

  • Larsson, Linus
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Nilsson, Måns
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Revisorn och digitaliseringen: En kvalitativ studie om nya förväntningar på revisorns kompetens2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Digitaliseringen har bidragit till en omfattande förändring av många branscher. Revision och kraven på revisorns kompetens är i stor utsträckning styrt av regler, men i och med digitaliseringen har det i forskningen framkommit nya förväntningar på vad revisorn ska besitta för kompetenser. Syftet med föreliggande studie var att undersöka i vilken utsträckning yrkesverksamma revisorer upplever att dessa nya förväntningar på kompetens infriats och idag anses nödvändiga i yrkesutförandet, vilket skulle kunna innebära att de formella kompetenskraven som revisorer möter har kompletterats med nya informella kompetenskrav. För att genomföra undersökningen hölls intervjuer med revisorer på två revisionsbyråer. Resultatet visade att basal informationsteknisk kompetens och en ökad analysförmåga hos revisorn utgör viktiga kompletterande kompetenser hos revisorn, och att den förstnämnda också är väsentlig för att behålla oberoendet. Däremot framkom det att förväntningar på mer avancerad informationsteknisk kompetens, ökad social kompetens och nya etiska aspekter relaterat till digitaliseringen inte var lika framträdande.

  • Josefsson, Andreas
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Öberg, Adam
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    När allt står på spel: En flerfallsstudie om hur dataspelsföretag väljer att hantera sina communities och dess betydelse för företagens framgång2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Dataspelsbranschen har vuxit explosionsartat de senaste åren, med skenande resultat och en stor ökning av nya företag. Forskning har visat att företag som har en utvecklad marknadsavkänningsförmåga (MAF) tenderar att prestera bättre när marknaden är i hastig förändring. Forskning har även gett indikation på att communities skulle kunna användas för att förstå hela företagets marknad. Syftet med uppsatsen är således att få förståelse för dataspelsföretagens val av communityhantering och vilken betydelse det har för företagens framgång. Vi har skapat vår egen analysmodell baserat på MAF, vilket vi kallar communityavkänningsförmåga (CAF). Spelrecensioner användes som en representativ variabel för att kunna studera företagens framgång. Intervjuer genomfördes med communityansvariga på fyra dataspelsföretag och uppgifter samlades in om användarnas spelrecensioner. Vi fann att företagen har en väletablerad CAF och att nästan hälften av alla produktutvecklings- och marknadsföringsbeslut baseras på communityt. Dock såg vi inget tydligt förhållande mellan hur mycket tid och resurser som läggs på CAF och vilka recensioner spelen får.

  • Vinterskog, Erik Axel
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Rissanen, Philip
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Familjeägandets påverkan på resultatkvalitet: bevis från Sverige2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie undersöker om det föreligger en skillnad i resultatkvalitet mellan familjeföretag och icke-familjeägda företag i en svensk kontext. Likt tidigare studier utgår denna studie från agentteorin, the alignment effect och the entrenchment effect. Majoriteten av tidigare studier inom området har främst genomförst i USA eller Ostasien och finner tvetydliga resultat. För att mäta hur ovan nämnda teorier påverkar familjeföretags resultatkvalitet i Sverige använder denna studie den modifierade Jones-modellen för att beräkna företagets diskretionära periodiseringar, vilka används som proxy för resultatkvalitet. Genom en multipel regressionsmodell på ett stickprov om 1475 observationer från NASDAQ Stokholms Large-, Mid- och Small cap-listor under perioden 2003 - 2013 finner denna studie, i enlighet med the entrenchment effect, att familjeföretag i genomsnitt har en högre grad av diskretionära periodiseringar än icke-familjeägda företag. 

  • Ovuk, Katarina
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Yusuf, Muna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ett svenskt detaljhandelsföretags internationaliseringsstrategi: en studie om att internationalisera i en digitaliserad tid2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Forskning inom området internationalisering har kritiserats för att inte ta hänsyn till effekten av digitaliseringen. Syftet med studien var att se om befintlig forskning inom området internationalisering kunde förklara en nutida internationaliseringsstrategi för ett svenskt detaljhandelsföretag. Vi ville uppnå en ökad förståelse för hur ett svenskt företag inom detaljhandeln anskaffat kunskap och internationaliserat sig i en tid där digitaliseringen har en omfattande betydelse.  Primärdata insamlades kvalitativt via semi-strukturerade intervjuer på det undersökta företaget. Resultatet tyder på att företagets internationaliseringsstrategi på flera sätt stämde överens med processen presenterad i Uppsalamodellen. Vidare framgick av resultatet att företaget under senare år hade arbetat mycket med att vara tillgängliga online, de hade dock inte upprättat en e-varuhandel. Detta främst då upprättandet av en e-varuhandel sågs som kostsamt och riskfyllt men även för att företaget ansåg att det fanns en stor målgrupp som sökte sig till fysiska butiker än idag, vilket således skapade incitament för att fortsatt vara en fysisk detaljhandelsbutik.

  • Johansson, Ebba
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Bellinder, Sofia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    En lärande organisation?: en pragmatisk teoretisk modell för lärande organisationer2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Under 1990-talet populariserades fenomenet lärande organisationer för att bemöta den konkurrens som globaliseringen medförde. Det finns både nya och mer klassiska forskningsstudier inom fenomenet lärande organisationer. Nyare studier inom fältet har försökt att skapa en heltäckande bild om lärande organisationer. Dessa studier tenderar dock att vara för smala och leder därmed till en alltför ytlig bild. Syftet med denna studie är därför att generera kunskaper om hur ett företag kan ses som en lärande organisationer genom en hybridmodell. Denna hybridmodell kombinerar Senges (2006) organisatoriska strukturer för innovativt lärande, tillsammans med Argyris och Schöns (1996) teori om olika nivåer av lärande. Studien har därmed en deduktiv ansats och den metod som studien använder är kvalitativa intervjuer. Resultaten visar att samtliga organisatoriska strukturer för innovativt lärande går att återfinna samt att dessa tillsammans leder till en djupare nivå av lärande. Slutsatsen av denna studie är därmed att denna hybridmodell kan ses som ett komplement till framtida studier inom området och att resultaten av denna studie tycks gå i linje med befintlig forskning inom området.

  • Rusak, J. A.
    et al.
    Ontario Minist Environm & Climate Change, Dorset Environm Sci Ctr, Dorset, ON, Canada.
    Tanentzap, A. J.
    Univ Cambridge, Dept Plant Sci, Cambridge, England.
    Klug, J. L.
    Fairfield Univ, Biol Dept, Fairfield, CT 06430 USA.
    Rose, K. C.
    Rensselaer Polytech Inst, Dept Biol Sci, Troy, NY USA.
    Hendricks, S. P.
    Murray State Univ, Hancock Biol Stn, Murray, KY 42071 USA.
    Jennings, E.
    Dundalk Inst Technol, Ctr Freshwater & Environm Studies, Dundalk, Ireland.
    Laas, A.
    Estonian Univ Life Sci, Chair Hydrobiol & Fishery, Tartu, Estonia.
    Pierson, Don
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Ryder, E.
    Dundalk Inst Technol, Ctr Freshwater & Environm Studies, Dundalk, Ireland.
    Smyth, R. L.
    Bard Coll, Environm & Urban Studies, Annandale On Hudson, NY 12504 USA.
    White, D. S.
    Murray State Univ, Hancock Biol Stn, Murray, KY 42071 USA.
    Winslow, L. A.
    Rensselaer Polytech Inst, Dept Biol Sci, Troy, NY USA.
    Adrian, R.
    Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany;Free Univ Berlin, Dept Biol Chem & Pharm, Berlin, Germany.
    Arvola, L.
    Univ Helsinki, Lammi Biol Stn, Lammi, Finland.
    de Eyto, E.
    Marine Inst, Newport, Co Mayo, Ireland.
    Feuchtmayr, H.
    Lancaster Environm Ctr, Ctr Ecol & Hydrol, Lancaster, England.
    Honti, M.
    Hungarian Acad Sci, MTA BME Water Res Grp, Budapest, Hungary.
    Istvanovics, V.
    Hungarian Acad Sci, MTA BME Water Res Grp, Budapest, Hungary.
    Jones, I. D.
    Lancaster Environm Ctr, Ctr Ecol & Hydrol, Lancaster, England.
    McBride, C. G.
    Univ Waikato, Environm Res Inst, Hamilton, New Zealand.
    Schmidt, S. R.
    Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany;Univ Potsdam, Inst Earth & Environm Sci, Potsdam, Germany.
    Seekell, D.
    Umea Univ, Dept Ecol & Environm Sci, Umea, Sweden.
    Staehr, P. A.
    Aarhus Univ, Dept Biosci, Roskilde, Denmark.
    Zhu, G.
    Chinese Acad Sci, Nanjing Inst Geog & Limnol, Nanjing, Jiangsu, Peoples R China.
    Wind and trophic status explain within and among-lake variability of algal biomass2018In: LIMNOLOGY AND OCEANOGRAPHY LETTERS, ISSN 2378-2242, Vol. 3, no 6, p. 409-418Article in journal (Refereed)
    Abstract [en]

    Phytoplankton biomass and production regulates key aspects of freshwater ecosystems yet its variability and subsequent predictability is poorly understood. We estimated within-lake variation in biomass using high-frequency chlorophyll fluorescence data from 18 globally distributed lakes. We tested how variation in fluorescence at monthly, daily, and hourly scales was related to high-frequency variability of wind, water temperature, and radiation within lakes as well as productivity and physical attributes among lakes. Within lakes, monthly variation dominated, but combined daily and hourly variation were equivalent to that expressed monthly. Among lakes, biomass variability increased with trophic status while, within-lake biomass variation increased with increasing variability in wind speed. Our results highlight the benefits of high-frequency chlorophyll monitoring and suggest that predicted changes associated with climate, as well as ongoing cultural eutrophication, are likely to substantially increase the temporal variability of algal biomass and thus the predictability of the services it provides.