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  • Molochkov, Alexander
    et al.
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Begun, Alexander
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Niemi, Antti
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Univ Tours, Lab Math & Phys Theor, Federat Denis Poisson, France.; Beijing Inst Technol, Dept Phys, Beijing, Peoples R China..
    Gauge symmetries and structure of proteins2017In: XIITH QUARK CONFINEMENT AND THE HADRON SPECTRUM / [ed] Foka, Y Brambilla, N Kovalenko, V, E D P SCIENCES , 2017, article id UNSP 04004Conference paper (Refereed)
    Abstract [en]

    We discuss the gauge field theory approach to protein structure study, which allows a natural way to introduce collective degrees of freedom and nonlinear topological structures. Local symmetry of proteins and its breaking in the medium is considered, what allows to derive Abelian Higgs model of protein backbone, correct folding of which is defined by gauge symmetry breaking due hydrophobic forces. Within this model structure of protein backbone is defined by superposition of one-dimensional topological solitons (kinks), what allows to reproduce the three-dimensional structure of the protein backbone with precision up to 1A and to predict its dynamics.

  • Eriksson, Jörgen
    et al.
    Lund University.
    Lagvik, Christer
    Uppsala University, University Library.
    Nolin, Emma
    Lund University.
    Moving towards open science? Conference report: the 9th Conference on Open Access Scholarly Publishing, Lisbon, September 20-21, 20172017In: Nordic Perspectives on Open Science, ISSN 2464-1839, Vol. 1Article in journal (Other academic)
    Abstract [en]

    The Conference on Open Access Scholarly Publishing, COASP, is held annually with the aim of reaching professional publishing organizations, independent publishers and university presses, as well as librarians, university administrators and other stakeholders. Here, we outline some themes and highlights from this year´s conference.

  • Dong, Zhihua
    et al.
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Schonecker, Stephan
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Chen, Dengfu
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Li, Wei
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Long, Mujun
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Vitos, Levente
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.;Wigner Res Ctr Phys, Res Inst Solid State Phys & Opt, POB 49, H-1525 Budapest, Hungary..
    Elastic properties of paramagnetic austenitic steel at finite temperature: Longitudinal spin fluctuations in multicomponent alloys2017In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, no 17, article id 174415Article in journal (Refereed)
    Abstract [en]

    We propose a first-principles framework for longitudinal spin fluctuations (LSFs) in disordered paramagnetic (PM) multicomponent alloy systems and apply it to investigate the influence of LSFs on the temperature dependence of two elastic constants of PM austenitic stainless steel Fe15Cr15Ni. The magnetic model considers individual fluctuating moments in a static PM medium with first-principles-derived LSF energetics in conjunction with describing chemical disorder and randomness of the transverse magnetic component in the single-site alloy formalism and disordered local moment (DLM) picture. A temperature-sensitive mean magnetic moment is adopted to accurately represent the LSF state in the elastic-constant calculations. We make evident that magnetic interactions between an LSF impurity and the PM medium are weak in the present steel alloy. This allows gaining accurate LSF energetics and mean magnetic moments already through a perturbation from the static DLM moments instead of a tedious self-consistent procedure. We find that LSFs systematically lower the cubic shear elastic constants c' and c(44) by similar to 6 GPa in the temperature interval 300-1600 K, whereas the predominant mechanism for the softening of both elastic constants with temperature is the magneto-volume coupling due to thermal lattice expansion. We find that non-negligible local magnetic moments of Cr and Ni are thermally induced by LSFs, but they exert only a small influence on the elastic properties. The proposed framework exhibits high flexibility in accurately accounting for finite-temperature magnetism and its impact on the mechanical properties of PM multicomponent alloys.

  • Cornils, L.
    et al.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Kamlapure, A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Zhou, L.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Max Planck Inst Solid State Res, D-70569 Stuttgart, Germany..
    Pradhan, Saurabh
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Khajetoorians, A. A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands..
    Fransson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Wiebe, J.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Wiesendanger, R.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Spin-Resolved Spectroscopy of the Yu-Shiba-Rusinov States of Individual Atoms2017In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 119, no 19, article id 197002Article in journal (Refereed)
    Abstract [en]

    A magnetic atom in a superconducting host induces so-called Yu-Shiba-Rusinov (YSR) bound states inside the superconducting energy gap. By combining spin-resolved scanning tunneling spectroscopy with simulations we demonstrate that the pair of peaks associated with the YSR states of an individual Fe atom coupled to an oxygen-reconstructed Ta surface gets spin polarized in an external magnetic field. As theoretically predicted, the electron and hole parts of the YSR states have opposite signs of spin polarizations which keep their spin character when crossing the Fermi level through the quantum phase transition. The simulation of a YSR state right at the Fermi level reveals zero spin polarization which can be used to distinguish such states from Majorana zero modes in chains of YSR atoms.

  • Garousi, Javad
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Lindbo, Sarah
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Buijs, Jos
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Hober, Sophia
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 14780Article in journal (Refereed)
    Abstract [en]

    ABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 derivatives as targeting moiety have provided excellent preclinical radionuclide imaging of human epidermal growth factor 2 (HER2) tumor xenografts. Previous studies have demonstrated that selection of nuclide and chelator for its conjugation has an appreciable effect on imaging properties of scaffold proteins. In this study we performed a comparative evaluation of the anti-HER2 ADAPT having an aspartate-glutamate-alanine-valine-aspartate-alanine-asparagine-serine (DEAVDANS) N-terminal sequence and labeled at C-terminus with (99)mTc using a cysteine-containing peptide based chelator, glycine-serine-serine-cysteine (GSSC), and a similar variant labeled with In-111 using a maleimido derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator. Both (99)mTc-DEAVDANS-ADAPT6-GSSC and In-111-DEAVDANS-ADAPT6-GSSC-DOTA accumulated specifically in HER2-expressing SKOV3 xenografts. The tumor uptake of both variants did not differ significantly and average values were in the range of 19-21% ID/g. However, there was an appreciable variation in uptake of conjugates in normal tissues that resulted in a notable difference in the tumor-to-organ ratios. The In-111-DOTA label provided 2-6 fold higher tumor-to-organ ratios than (99)mTc-GSSC and is therefore the preferable label for ADAPTs.

  • Bah, Ibrahima
    et al.
    Univ Calif San Diego, La Jolla, USA; Johns Hopkins Univ, Baltimore, USA.
    Passias, Achilleas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Tomasiello, Alessandro
    Univ Milano Bicocca, Milan, Italy; INFN, Milan, Italy.
    AdS(5) compactifications with punctures in massive IIA supergravity2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 11, article id 050Article in journal (Refereed)
    Abstract [en]

    We find AdS(5) solutions holographically dual to compactifications of six-dimensional N=(1,0) supersymmetric field theories on Riemann surfaces with punctures. We simplify a previous analysis of supersymmetric AdS(5) IIA solutions, and with a suitable Ansatz we find explicit solutions organized in three classes, where an O8-D8 stack, D6- and D4-branes are simultaneously present, localized and partially localized. The D4-branes are smeared over the Riemann surface and this is interpreted as the presence of a uniform distribution of punctures. For the first class we identify the corresponding six-dimensional theory as an E-string theory coupled to a quiver gauge theory. The second class of solutions lacks D6-branes and its central charge scales as n(5/2), suggesting a five-dimensional origin for the dual field theory. The last class has elements of the previous two.

  • Aaboud, M.
    et al.
    Université Mohamed Premier, Faculté des Sciences; LPTPM, Oujda.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, M.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, M.U.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, P.H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva.
    Search for a scalar partner of the top quark in the jets plus missing transverse momentum final state at √s=13 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 085Article in journal (Refereed)
    Abstract [en]

    A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. An analysis of 36.1 fb(-1) of root s = 13 TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via (t) over tilde (1) -> t((*)) (chi) over tilde (0)(1) and (t) over tilde (1) -> b (chi) over tilde (+/-)(1) -> bW((*)) (chi) over tilde (0)(1), where (chi) over tilde (0)(1) ((chi) over tilde (+/-)(1) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t (chi) over tilde (0)(1), top-squark masses in the range 450-1000 GeV are excluded for (chi) over tilde (0)(1) masses below 160 GeV. In the case where m((t) over tilde1) similar to m(t) + m((chi) over tilde 10), top-squark masses in the range 235-590 GeV are excluded.

  • Jabs, Verena
    et al.
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Edlund, Karolina
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Koenig, Helena
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Grinberg, Marianna
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Madjar, Katrin
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Rahnenfuehrer, Joerg
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Ekman, Simon
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden..
    Bergkvist, Michael
    Gavle Cent Hosp, Dept Oncol, Gavle, Sweden..
    Holmberg, Lars
    Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.;Kings Coll London, Fac Life Sci & Med, Div Canc Studies, London, England..
    Ickstadt, Katja
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Botling, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Hengstler, Jan G.
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Micke, Patrick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187246Article in journal (Refereed)
    Abstract [en]

    Non-small cell lung cancer (NSCLC) represents a genomically unstable cancer type with extensive copy number aberrations. The relationship of gene copy number alterations and subsequent mRNA levels has only fragmentarily been described. The aim of this study was to conduct a genome-wide analysis of gene copy number gains and corresponding gene expression levels in a clinically well annotated NSCLC patient cohort (n = 190) and their association with survival. While more than half of all analyzed gene copy number-gene expression pairs showed statistically significant correlations (10,296 of 18,756 genes), high correlations, with a correlation coefficient >0.7, were obtained only in a subset of 301 genes (1.6%), including KRAS, EGFR and MDM2. Higher correlation coefficients were associated with higher copy number and expression levels. Strong correlations were frequently based on few tumors with high copy number gains and correspondingly increased mRNA expression. Among the highly correlating genes, GO groups associated with posttranslational protein modifications were particularly frequent, including ubiquitination and neddylation. In a meta-analysis including 1,779 patients we found that survival associated genes were overrepresented among highly correlating genes (61 of the 301 highly correlating genes, FDR adjusted p<0.05). Among them are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1. In conclusion, in a comprehensive analysis we described a distinct set of highly correlating genes. These genes were found to be overrepresented among survival-associated genes based on gene expression in a large collection of publicly available datasets.

  • Fenteng, Eunice Akua
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Erfarenheter och upplevelser av egenvård över tid hos personer med typ 1 diabetes: En intervjustudie2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • Ali, Abir Salwa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Grönberg, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Federspiel, Birgitte
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Scoazec, Jean-Yves
    Inst Gustave Roussy, Villejuif, France.
    Hjortland, Geir Olav
    Univ Oslo, Oslo, Norway.
    Gronbaek, Henning
    Aarhus Univ Hosp, Aarhus, Denmark.
    Ladekarl, Morten
    Aarhus Univ Hosp, Aarhus, Denmark.
    Langer, Seppo W.
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Welin, Staffan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Vestermark, Lene Weber
    Odense Univ Hosp, Odense, Denmark.
    Arola, Johanna
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland.
    Osterlund, Pia
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Tampere Univ Hosp, Tampere, Finland.
    Knigge, Ulrich
    Univ Copenhagen, Rigshosp, Copenhagen, Denmark.
    Sorbye, Halfdan
    Haukeland Hosp, Bergen, Norway; Univ Bergen, Bergen, Norway.
    Grimelius, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology. Uppsala Univ, Sect Endocrine Oncol, Dept Med Sci, Uppsala, Sweden..
    Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187667Article in journal (Refereed)
    Abstract [en]

    Background Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are aggressive, rapidly proliferating tumors. Therapeutic response to current chemotherapy regimens is usually short lasting. The aim of this study was to examine the expression and potential clinical importance of immunoreactive p53 protein in GEP-NEC. Materials and methods Tumor tissues from 124 GEP-NEC patients with locally advanced or metastatic disease treated with platinum-based chemotherapy were collected from Nordic centers and clinical data were obtained from the Nordic NEC register. Tumor proliferation rate and differentiation were re-evaluated. All specimens were immunostained for p53 protein using a commercially available monoclonal antibody. Kaplan-Meier curves and cox regression analyses were used to assess progression-free survival (PFS) and overall survival (OS). Results All tumor tissues were immunoreactive for either one or both neuroendocrine biomarkers (chromogranin A and synaptophysin) and Ki67 index was >20% in all cases. p53 immunoreactivity was only shown in 39% of the cases and was not found to be a prognostic marker for the whole cohort. However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. Conclusion In this cohort of GEP-NEC patients, p53 expression could not be correlated with clinical outcome. However, in patients with colorectal NECs, p53 expression was correlated with shorter PFS and OS. Further studies are needed to establish the role of immunoreactive p53 as a prognostic marker for GEP-NEC patients.

  • Pool, Sandra
    et al.
    Univ Zurich, Zurich, Switzerland.
    Vis, Marc J. P.
    Univ Zurich, Zurich, Switzerland.
    Knight, Rodney R.
    US Geol Survey, Nashville, USA.
    Seibert, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Univ Zurich, Zurich, Switzerland; Stockholm Univ, Stockholm, Sweden.
    Streamflow characteristics from modeled runoff time series importance of calibration criteria selection2017In: Hydrology and Earth System Sciences, ISSN 1027-5606, E-ISSN 1607-7938, Vol. 21, no 11, p. 5443-5457Article in journal (Refereed)
    Abstract [en]

    Ecologically relevant streamflow characteristics (SFCs) of ungauged catchments are often estimated from simulated runoff of hydrologic models that were originally calibrated on gauged catchments. However, SFC estimates of the gauged donor catchments and subsequently the ungauged catchments can be substantially uncertain when models are calibrated using traditional approaches based on optimization of statistical performance metrics (e.g., Nash-Sutcliffe model efficiency). An improved calibration strategy for gauged catchments is therefore crucial to help reduce the uncertainties of estimated SFCs for ungauged catchments. The aim of this study was to improve SFC estimates from modeled runoff time series in gauged catchments by explicitly including one or several SFCs in the calibration process. Different types of objective functions were defined consisting of the Nash-Sutcliffe model efficiency, single SFCs, or combinations thereof. We calibrated a bucket-type runoff model (HBV-Hydrologiska Byrans Vattenavdelning-model) for 25 catchments in the Tennessee River basin and evaluated the proposed calibration approach on 13 ecologically relevant SFCs representing major flow regime components and different flow conditions. While the model generally tended to underestimate the tested SFCs related to mean and high-flow conditions, SFCs related to low flow were generally overestimated. The highest estimation accuracies were achieved by a SFC-specific model calibration. Estimates of SFCs not included in the calibration process were of similar quality when comparing a multi-SFC calibration approach to a traditional model efficiency calibration. For practical applications, this implies that SFCs should preferably be estimated from targeted runoff model calibration, and modeled estimates need to be carefully interpreted.

  • Liao, Qinghua
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pabis, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strodel, Birgit
    Forschungszentrum Julich, Julich, Germany; Heinrich Heine Univ Dusseldorf, Dusseldorf, Germany.
    Kamerlin, Shina Caroline Lynn
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.
    Extending the Nonbonded Cationic Dummy Model to Account for Ion-Induced Dipole Interactions2017In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 8, no 21, p. 5408-5414Article in journal (Refereed)
    Abstract [en]

    Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to the central metal ion in a predefined coordination geometry. While this approach allows for ligand exchange, and captures the correct electrostatics as demonstrated for different divalent metal ions, current dummy models neglect ion-induced dipole interactions. In the present work, we resolve this weakness by taking advantage of the recently introduced 12-6-4 type Lennard-Jones potential to include ion-induced dipole interactions. We revise our previous dummy model for Mg2+ and demonstrate that the resulting model can simultaneously reproduce the experimental solvation free energy and metal ligand distances without the need for artificial restraints or bonds. As ion-induced dipole interactions become particularly important for highly charged metal ions, we develop dummy models for the biologically relevant ions Al3+, Fe3+, and Cr3+. Finally, the effectiveness of our new models is demonstrated in MD simulations of several diverse (and highly challenging to simulate) metalloproteins.

  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Achasov, M. N.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Ahmed, S.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Ai, X. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    AlbayraK, O.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Albrecht, M.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Ambrose, D. J.
    Univ Rochester, 601 Elmwood Ave, Rochester, NY 14627 USA. Univ Sci & Technol Liaoning, Anshan 114051, Peoples R China..
    Amoroso, A.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy.;Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    An, F. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    An, Q.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Bai, J. Z.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ferroli, R. Baldini
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy.;INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Ban, Y.
    Peking Univ, Beijing 100871, Peoples R China..
    Bennett, D. W.
    Indiana Univ, Bloomington, IN 47405 USA..
    Bennett, J. V.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Berger, N.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Bertani, M.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Bettoni, D.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Bian, J. M.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Bianchi, F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Boger, E.
    Joint Inst Nucl Res, Moscow 141980, Russia.;Moscow Inst Phys & Technol, Moscow 141700, Russia..
    Boyko, I.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Briere, R. A.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Cai, H.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Cai, X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Cakir, O.
    Ankara Univ, TR-06100 Ankara, Turkey..
    Calcaterra, A.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Cao, G. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Cetin, S. A.
    Istanbul Bilgi Univ, TR-34060 Istanbul, Turkey. Uludag Univ, TR-16059 Bursa, Turkey. Near East Univ, Mersin 10, Nicosia, North Cyprus, Turkey..
    Chai, J.
    Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Chang, J. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chelkov, G.
    Joint Inst Nucl Res, Moscow 141980, Russia.;Moscow Inst Phys & Technol, Moscow 141700, Russia.;Tomsk State Univ, Funct Elect Lab, Tomsk 634050, Russia..
    Cheng, G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, H. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, J. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, M. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, S.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Chen, S. J.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Chen, X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, X. R.
    Lanzhou Univ, Lanzhou 730000, Gansu, Peoples R China..
    Chen, Y. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, H. P.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Chu, X. K.
    Peking Univ, Beijing 100871, Peoples R China..
    Cibinetto, G.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Dai, H. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dai, J. P.
    Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China..
    Dbeyssi, A.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Dedovich, D.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Deng, Z. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Denig, A.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Denysenko, I.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Destefanis, M.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    De Mori, F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Ding, Y.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Dong, C.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Dong, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dong, L. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Dong, M. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dou, Z. L.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Du, S. X.
    Zhengzhou Univ, Zhengzhou 450001, Henan, Peoples R China..
    Duan, P. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Fan, J. Z.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Fang, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fang, S. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Fang, X.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fang, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Farinelli, R.
    Univ Ferrara, I-44122 Ferrara, Italy..
    Fava, L.
    Univ Piemonte Orientale, I-15121 Alessandria, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Fedorov, O.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Feldbauer, F.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Felici, G.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Feng, C. Q.
    Cent China Normal Univ, Wuhan 430079, Hubei, Peoples R China. China Ctr Adv Sci & Technol, Beijing 100190, Peoples R China. COMSATS Inst Informat Technol, Def Rd,Raiwind Rd, Lahore 54000, Pakistan.;Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fioravanti, E.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Fritsch, M.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany.;Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Fu, C. D.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Gao, Q.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Gao, X. L.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gao, Y.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Gao, Z.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Garzia, I.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Goetzen, K.
    GSI Helmholtzctr Heavy Ion Res GmbH, D-64291 Darmstadt, Germany..
    Gong, L.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Gong, W. X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gradl, W.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Greco, M.
    Univ Turin, I-10125 Turin, Italy..
    Gu, M. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gu, Y. T.
    Guangxi Univ, Nanning 530004, Peoples R China..
    Guan, Y. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Q.
    Guo, L. B.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Guo, R. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Y. P.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Haddadi, Z.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Hafner, A.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Han, S.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Hao, X. Q.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Harris, F. A.
    Univ Hawaii, Honolulu, HI 96822 USA..
    He, K. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Heinsius, F. H.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Held, T.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Heng, Y. K.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Holtmann, T.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Hou, Z. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Hu, C.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Hu, H. M.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Hu, J. F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Hu, T.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Hu, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Huang, G. S.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Huang, J. S.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Huang, X. T.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Huang, X. Z.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Huang, Y.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Huang, Z. L.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Hussain, T.
    Univ Punjab, Lahore 54590, Pakistan..
    Ji, Q.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ji, Q. P.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Ji, X. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ji, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jiang, L. W.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Jiang, X. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jiang, X. Y.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Jiao, J. B.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Jiao, Z.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Jin, D. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jin, S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Julin, A.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Kalantar-Nayestanaki, N.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Kang, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Kang, X. S.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Kavatsyuk, M.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Ke, B. C.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Kiese, P.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kliemt, R.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kloss, B.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kolcu, O. B.
    Istanbul Bilgi Univ, TR-34060 Istanbul, Turkey. Uludag Univ, TR-16059 Bursa, Turkey. Near East Univ, Mersin 10, Nicosia, North Cyprus, Turkey.;Istanbul Arel Univ, TR-34295 Istanbul, Turkey. Goethe Univ Frankfurt, D-60323 Frankfurt, Germany..
    Kopf, B.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Kornicer, M.
    Univ Hawaii, Honolulu, HI 96822 USA..
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kuhn, W.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Lange, J. S.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Lara, M.
    Indiana Univ, Bloomington, IN 47405 USA..
    Larin, P.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Leithoff, H.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Leng, C.
    Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cheng
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, D. M.
    Zhengzhou Univ, Zhengzhou 450001, Henan, Peoples R China..
    Li, F.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, F. Y.
    Peking Univ, Beijing 100871, Peoples R China..
    Li, G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, H. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, H. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, J. C.
    Li, Jin
    Seoul Natl Univ, Seoul 151747, South Korea..
    Li, K.
    Hangzhou Normal Univ, Hangzhou 310036, Zhejiang, Peoples R China.;Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, Lei
    Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China..
    Li, P. R.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Li, Q. Y.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, T.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, W. D.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, W. G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, X. N.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, X. Q.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Li, Y. B.
    Beihang Univ, Beijing 100191, Peoples R China..
    Li, Z. B.
    Sun Yat Sen Univ, Guangzhou 510275, Guangdong, Peoples R China..
    Liang, H.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liang, Y. F.
    Sichuan Univ, Chengdu 610064, Sichuan, Peoples R China. Soochow Univ, Suzhou 215006, Peoples R China..
    Liang, Y. T.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Liao, G. R.
    Guangxi Normal Univ, Guilin 541004, Peoples R China..
    Lin, D. X.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Liu, B.
    Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China..
    Liu, B. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, C. X.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, D.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, F. H.
    Shanxi Univ, Taiyuan 030006, Shanxi, Peoples R China..
    Liu, Fang
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, Feng
    Liu, H. B.
    Guangxi Univ, Nanning 530004, Peoples R China..
    Liu, H. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, H. M.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, J. B.
    State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, J. P.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Liu, J. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, K.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Liu, K. Y.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Liu, L. D.
    Peking Univ, Beijing 100871, Peoples R China..
    Liu, P. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, Q.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Liu, S. B.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, X.
    Lanzhou Univ, Lanzhou 730000, Gansu, Peoples R China..
    Liu, Y. B.
    Liu, Y. Y.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Liu, Z. A.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, Zhiqing
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Loehner, H.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Long, Y. F.
    Peking Univ, Beijing 100871, Peoples R China..
    Lou, X. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey.;Univ Texas Dallas, Richardson, TX 75083 USA..
    Lu, H. J.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Lu, J. G.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Lu, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Lu, Y. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Luo, C. L.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Luo, M. X.
    Zhejiang Univ, Hangzhou 310027, Zhejiang, Peoples R China..
    Luo, T.
    Univ Hawaii, Honolulu, HI 96822 USA..
    Luo, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Lyu, X. R.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Ma, F. C.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Ma, H. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ma, L. L.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Ma, M. M.
    Ma, Q. M.
    Ma, T.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ma, X. N.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Ma, X. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Ma, Y. M.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Maas, F. E.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Maggiora, M.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Malik, Q. A.
    Univ Punjab, Lahore 54590, Pakistan..
    Mao, Y. J.
    Peking Univ, Beijing 100871, Peoples R China..
    Mao, Z. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Marcello, S.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Messchendorp, J. G.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Mezzadri, G.
    Univ Ferrara, I-44122 Ferrara, Italy..
    Min, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Min, T. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Mitchell, R. E.
    Indiana Univ, Bloomington, IN 47405 USA..
    Mo, X. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Mo, Y. J.
    Cent China Normal Univ, Wuhan 430079, Hubei, Peoples R China. China Ctr Adv Sci & Technol, Beijing 100190, Peoples R China. COMSATS Inst Informat Technol, Def Rd,Raiwind Rd, Lahore 54000, Pakistan.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Morales, C. Morales
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Muchno, N. Yu.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Muramatsu, H.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Musiol, P.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Nefedov, Y.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Nerling, F.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Nikolaev, I. B.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Ning, Z.
    Nisar, S.
    Niu, S. L.
    Niu, X. Y.
    Olsen, S. L.
    Ouyang, Q.
    Pacetti, S.
    Pan, Y.
    Patteri, P.
    Pelizaeus, M.
    Peng, H. P.
    Peters, K.
    Pettersson, J.
    Ping, J. L.
    Ping, R. G.
    Poling, R.
    Prasad, V.
    Qi, H. R.
    Qi, M.
    Qian, S.
    Qiao, C. F.
    Qin, L. Q.
    Qin, N.
    Qin, X. S.
    Qin, Z. H.
    Qiu, J. F.
    Rashid, K. H.
    Redmer, C. F.
    Ripka, M.
    Rong, G.
    Rosner, Ch.
    Ruan, X. D.
    Sarantsev, A.
    Savrie, M.
    Schnier, C.
    Schoenning, K.
    Schumann, S.
    Shan, W.
    Shao, M.
    Shen, C. P.
    Shen, P. X.
    Shen, X. Y.
    Shen, H. Y.
    Shi, M.
    Song, W. M.
    Song, X. Y.
    Sosio, S.
    Spataro, S.
    Sun, G. X.
    Sun, J. F.
    Sun, S. S.
    Sun, X. H.
    Sun, Y. J.
    Sun, Y. Z.
    Sun, Z. J.
    Sun, Z. T.
    Tang, C. J.
    Tang, X.
    Tapan, I.
    Thorndike, E. H.
    Tiemens, M.
    Uman, I.
    Varner, G. S.
    Wang, B.
    Wang, B. L.
    Wang, D.
    Wang, D. Y.
    Wang, K.
    Wang, L. L.
    Wang, L. S.
    Wang, M.
    Wang, P.
    Wang, P. L.
    Wang, W.
    Wang, W. P.
    Wang, X. F.
    Wang, Y.
    Wang, Y. D.
    Wang, Y. F.
    Wang, Y. Q.
    Wang, Z.
    Wang, Z. G.
    Wang, Z. H.
    Wang, Z. Y.
    Weber, T.
    Wei, D. H.
    Weidenkaff, P.
    Wen, S. P.
    Wiedner, U.
    Wolke, M.
    Wu, L. H.
    Wu, L. J.
    Wu, Z.
    Xia, L.
    Xia, L. G.
    Xia, Y.
    Xiao, D.
    Xiao, H.
    Xiao, Z. J.
    Xie, Y. G.
    Xiu, Q. L.
    Xui, G. F.
    Xu, J. J.
    Xu, L.
    Xu, Q. J.
    Xu, Q. N.
    Xu, X. P.
    Yan, L.
    Yan, W. B.
    Yan, W. C.
    Yan, Y. H.
    Yang, H. J.
    Yang, H. X.
    Yang, L.
    Yang, Y. X.
    Ye, M.
    Ye, M. H.
    Yin, J. H.
    You, Z. Y.
    Yu, B. X.
    Yu, C. X.
    Yu, J. S.
    Yuan, C. Z.
    Yuan, W. L.
    Yuan, Y.
    Yun, A.
    Zafar, A. A.
    Zallo, A.
    Zeng, Y.
    Zeng, Z.
    Zhang, B. X.
    Zhang, B. Y.
    Zhang, C.
    Zhang, C. C.
    Zhang, D. H.
    Zhang, H. H.
    Zhang, H. Y.
    Zhang, J.
    Zhang, J. J.
    Zhang, J. L.
    Zhang, J. Q.
    Zhang, J. W.
    Zhang, J. Y.
    Zhang, J. Z.
    Zhang, K.
    Zhang, L.
    Zhang, S. Q.
    Zhang, X. Y.
    Zhang, Y.
    Zhang, Y. H.
    Zhang, Y. N.
    Zhang, Y. T.
    Zhang, Yu
    Zhang, Z. H.
    Zhang, Z. P.
    Zhang, Z. Y.
    Zhao, G.
    Zhao, J. W.
    Zhao, J. Y.
    Zhao, J. Z.
    Zhao, Lei
    Zhao, Ling
    Zhao, M. G.
    Zhao, Q.
    Zhao, Q. W.
    Zhao, S. J.
    Zhao, T. C.
    Zhao, Y. B.
    Zhao, Z. G.
    Zhemchugov, A.
    Zheng, B.
    Zheng, J. P.
    Zheng, W. J.
    Zheng, Y. H.
    Zhong, B.
    Zhou, L.
    Zhou, X.
    Zhou, X. K.
    Zhou, X. R.
    Zhou, X. Y.
    Zhu, K.
    Zhu, K. J.
    Zhu, S.
    Zhu, S. H.
    Zhu, X. L.
    Zhu, Y. C.
    Zhu, Y. S.
    Zhu, Z. A.
    Zhuang, J.
    Zotti, L.
    Zou, B. S.
    Zou, J. H.
    Measurement of integrated luminosity and center-of-mass energy of data taken by BESIII at √s=2.125 GeV2017In: Chinese Physics C, High Energy Physics & Nuclear Physics, ISSN 1674-1137, E-ISSN 0899-9996, Vol. 41, no 11, article id 113001Article in journal (Refereed)
    Abstract [en]

    To study the nature of the state Y (2175), a dedicated data set of e(+)e(-) collision data was collected at the center-of-mass energy of 2.125 GeV with the BESIII detector at the BEPCII collider. By analyzing large-angle Bhabha scattering events, the integrated luminosity of this data set is determined to be 108.49 +/- 0.02 +/- 0.85 pb(-1), where the first uncertainty is statistical and the second one is systematic. In addition, the center-of-mass energy of the data set is determined with radiative dimuon events to be 2126.55 +/- 0.03 +/- 0.85 MeV, where the first uncertainty is statistical and the second one is systematic.

  • Kalafati, Margarita
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Risheden, Tova
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Smärta hos patienter med cancerdiagnos som vårdas palliativt: En litteraturöversikt2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Palliative care is provided to relieve suffering among patients’. Symptom control is an important aspect in the palliative care. Pain at end of life is a common phenomenon in patients’ with advanced cancer. Experienced pain increases suffering among patients’ at palliative care

    Aim: The purpose of this article is to compile research about pain experiences in patients with cancer diagnosis under palliative care.

    Method: A literature review where 10 qualitative original article were examined. The articles were found on CINAHL and PubMed and were analyzed using content analysis method.

    Results: Patients’ with advanced cancer had strong physical experiences of pain. Experienced pain also had a significant psychological impact, which had an effect on patients’ well-being. The descriptions of systematic pain measurement were different depending on the study. The articles’ results generally described patients’ similar thoughts and opinions about pain relief.

    Conclusion: Patients with cancer diagnosis under palliative care experience pain both physiologically and psychologically. Pain, and the effects of pain, prevents patients’ possibility for quality of life despite severe illness – one of the ambitions of palliative care. For an adequate pain measurement, an open and honest dialogue between patients’ and health care professionals is vital; which also requires the trust of healthcare professionals. Patients’ descriptions of pain relief prove a widespread ignorance and fear of pain relieving drugs among patients’. Much caused by health care professional’s lack of information.  

  • Grandi, Nicole
    et al.
    University of Cagliari, Cagliari, Italy.
    Cadeddu, Marta
    University of Cagliari, Cagliari, Italy.
    Pisano, Maria Paola
    University of Cagliari, Cagliari, Italy.
    Esposito, Francesca
    University of Cagliari, Cagliari, Italy.
    Blomberg, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology.
    Tramontano, Enzo
    University of Cagliari, Cagliari, Italy.
    Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion2017In: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 8, article id 15Article in journal (Refereed)
    Abstract [en]

    About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infections occurred millions of years ago in the germ line cells and being inherited by the offspring in a Mendelian fashion. HERV-K elements (classified as HML1-10) are among the most studied HERV groups, especially due to their possible correlation with human diseases. In particular, the HML10 group was reported to be upregulated in persistent HIV-1 infected cells as well as in tumor cells and samples, and proposed to have a role in the control of host genes expression. An individual HERV-K(HML10) member within the major histocompatibility complex C4 gene has even been studied for its possible contribution to type 1 diabetes susceptibility. Following a first characterization of the HML10 group at the genomic level, performed with the innovative software RetroTector, we have characterized in detail the 8 previously identified HML10 sequences present in the human genome, and an additional HML10 partial provirus in chromosome 1p22.2 that is reported here for the first time. Using a combined approach based on RetroTector software and a traditional Genome Browser Blat search, we identified a novel HERV-K(HML10) sequence in addition to the eight previously reported in the human genome GRCh37/hg19 assembly. We fully characterized the nine HML10 sequences at the genomic level, including their classification in two types based on both structural and phylogenetic characteristics, a detailed analysis of each HML10 nucleotide sequence, the first description of the presence of an Env Rec domain in the type II HML10, the estimated time of integration of individual members and the comparative map of the HML10 proviruses in non-human primates. We performed an unambiguous and exhaustive analysis of the nine HML10 sequences present in GRCh37/hg19 assembly, useful to increase the knowledge of the group's contribution to the human genome and laying the foundation for a better understanding of the potential physiological effects and the tentative correlation of these sequences with human pathogenesis.

  • Leino, Marina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    En kvalitativ syntes av anhörigas upplevelser under och efter närståendes plötsliga hjärtstopp2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Sudden cardiac arrest is a life threatening condition, not only affecting the patient but the whole family. The patient’s life is on hold and if the patient survives, this is often with more or less physical and psychological complications. Close to the patient a family member or relative, tries to support and help the patient while at the same time the situation may be extremely stressful for the relative.

    Aim: The aim of this qualitative literature review was to get a better understanding of family members lived experiences during a loved one’s sudden cardiac arrest, in order to better also support the relatives in healthcare.

    Method: A summary of the literature based on eight qualitative studies on the perceptions of family members experiences of a sudden cardiac arrest by a loved one; during the cardiac arrest, at the intensive care unit and after discharge from hospital.

    Results: The cardiac arrest was experienced as a chaotic and traumatic event by the relative. The patient was the most important person at the moment but at the same time it left the relative alone with her feelings of anxiety and fear that the situation induced. Receiving information continuously about their next of kin’s condition as well as a considerate and professional encounter with the intensive care unit staff was important for the relative. The possibility to stay with the patient at the intensive care unit felt comforting, reassuring and safe. Lack of information and follow up, as well as a feeling of being alone with the responsibility, was a common theme after discharge from the hospital.

    Conclusion: To be present during the next of kin’s cardiac arrest was a strong existential experience where all aspects of involvement and participation were described; to know, to do and to be. For best results, an involving care in the light, collaboration between the professional care, the patient and the family member is needed. More support and attention should be given to family members in the future.

  • Eriksson, Annie
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Stenberg, Lisa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    "Nu vill jag röra på mig, använda hela min kropp": En studie om fysisk aktivitet och dess inverkan på barns koncentration vid samling i förskolan.2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Public defence: 2018-03-10 10:00 Auditorium Minus, Uppsala
    Frisk, Pia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Surveys and services: The feasibility of conducting research in Swedish community pharmacies2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    For the past decades, there has been a shift in community pharmacy practice from dispensing and compounding towards provision of pharmacy services. Research is important to generate evidence for new services within pharmacy practice. Pharmacy practice research can be divided in two main themes: research related to pharmacy as a data source and to the pharmacy as the object of research, respectively.

    The purpose of this thesis is to increase the understanding of the conditions required for successful involvement of Swedish community pharmacy staff in pharmacy-based research, and to evaluate the data generated through a certain type of research: pharmacy-based patient surveys on drug utilization.

    Specific aims were to evaluate if there is a selection bias in drug utilization surveys conducted in Swedish community pharmacies, to explore the experiences of pharmacists either conducting the surveys or recruiting patients to research on adherence-promoting services, and to describe barriers and facilitators to conducting research in community pharmacies.

    Data were collected via pharmacy-based patient surveys, dispensing data, individual interviews, a cross-sectional staff survey and focus group interviews.

    In community pharmacy-based surveys or services research, with the dispensed drug as the trigger for inclusion, patients aged 75 years or older are underrepresented since they less often visit the pharmacy to redeem their prescriptions themselves. Due to their perceived workload, dispensing pharmacists sometimes avoid including patients perceived as complex due to age, polypharmacy or communication difficulties. These processes contribute to a healthy selection effect in both types of research and pharmacy services not reaching the patients in most need of support with their medication.

    The pharmacists were generally positive to conducting surveys and being involved in services research, but reported a perceived lack of sufficient communication and research skills, and a lack of time.

    Since competing commercial priorities hamper pharmacists’ research involvement, separate research funding is an important facilitator. For surveys to include all eligible patients, services to be relevant for both practice and patients and to target the patients in most need of support with their medication, research collaboration with healthcare, other professions and across pharmacies is also necessary.

    List of papers
    1. Selection bias in pharmacy-based patient surveys
    Open this publication in new window or tab >>Selection bias in pharmacy-based patient surveys
    2014 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 23, no 2, p. 128-139Article in journal (Refereed) Published
    Abstract [en]

    PurposeTo evaluate if there is a selection bias in drug utilization surveys on prescription drugs regularly conducted in Swedish pharmacies, to describe the direction of this potential bias and discuss the implications for the results. MethodsAge and gender distributions within patient survey samples from drug utilization surveys conducted during 2006-2010 are compared to the age and gender distribution of all Swedish patients, receiving the same drug or drugs, as given by the Swedish Prescribed Drug Register. The differences between the proportions of patients within the age and gender segments of each pair of survey/register data were calculated. ResultsIn 25 (81%) out of 31 included surveys, patients aged 75 years or older are significantly underrepresented, as they are less likely to visit the pharmacy to collect their prescription drugs themselves and thus disqualify for the interviews. Data on women show similar results as overall survey data, whereas the underrepresentation of the oldest age group among men appears in a lower proportion of the surveys, 67%. The general consequence is a selection towards a healthier survey sample, but the consequences in the individual surveys vary, depending on what drug is being studied. ConclusionPharmacy-based patient surveys provide a convenient data collection method for patient self-reported data, but patients aged 75 years or older are consistently underrepresented. In surveys where this may influence the main research question, data should also be collected with other methods reaching the oldest patients.

    Keyword
    patient survey, pharmacy, selection bias, drug utilization, self-report, pharmacoepidemiology
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-219194 (URN)10.1002/pds.3488 (DOI)000329999100003 ()
    Available from: 2014-02-25 Created: 2014-02-24 Last updated: 2018-01-19Bibliographically approved
    2. Exploring community pharmacists' experiences of surveying patients for drug utilization research purposes
    Open this publication in new window or tab >>Exploring community pharmacists' experiences of surveying patients for drug utilization research purposes
    2015 (English)In: International Journal of Clinical Pharmacy, ISSN 2210-7703, E-ISSN 2210-7711, Vol. 37, no 3, p. 522-528Article in journal (Refereed) Published
    Abstract [en]

    Background Patient self-reported data are important in drug utilization research, but often logistically difficult to collect. During 2006-2012, 72 Swedish community pharmacies regularly collected such data through structured survey interviews at the pharmacy counter, performed by the dispensing pharmacists. This study is part of a validation of that data acquisition method. Objectives (1) To explore the experiences of the pharmacists involved, (2) to explore a random or systematic exclusion of eligible patients by the pharmacists, and (3) to find areas of improvement to the applied method of surveying. Setting 72 Swedish community pharmacies, distributed all over the country. Method (a) A questionnaire was distributed to approximately 400 dispensing pharmacists at the pharmacies conducting the patient surveys; (b) semi-structured telephone interviews conducted with 19 pharmacists at 12 of the pharmacies. Main outcome measure Proportions of pharmacists reporting positive and negative experiences of structured survey interviews, the nature of their experiences, proportion of pharmacists reporting to avoid survey interviews and reasons for doing so, and suggested areas of improvement. Results A total of 126 pharmacists (32 %) completed the questionnaire. A majority (82 %) reported positive experiences of interviewing. In addition to the data generated as the primary goal of surveying, secondary benefits such as an improved patient-pharmacist dialogue and an increased detection and resolution of drug related problems were reported. However, a majority (63 %) of the pharmacists also reported negative experiences related to a perceived lack of time to fulfil one's professional obligations. Almost half of the pharmacists (44 %) in the survey admitted that they occasionally avoided interviewing eligible patients, due to the immediate increase in work load. The limited availability of staff resources was the most apparent area of improvement. Conclusion Under certain conditions, community pharmacies are feasible as a setting for conducting patient surveys in drug utilization research, and dispensing pharmacists suitable for conducting them. When regular dispensing staff perform the survey interviews as a part of the drug dispensing process, additional resources to manage the immediate increase in work load have to be considered. Otherwise, data quality may be compromised.

    Keyword
    Community pharmacy, Interview, Pharmacist, Survey, Sweden
    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-252961 (URN)10.1007/s11096-015-0088-1 (DOI)000353472100016 ()25736386 (PubMedID)
    Available from: 2015-05-20 Created: 2015-05-18 Last updated: 2018-01-19Bibliographically approved
    3. Utilisation of prescription and over-the-counter triptans: a cross-sectional study in Stockholm, Sweden
    Open this publication in new window or tab >>Utilisation of prescription and over-the-counter triptans: a cross-sectional study in Stockholm, Sweden
    Show others...
    2016 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 72, no 6, p. 747-754Article in journal (Refereed) Published
    Abstract [en]

    Triptans are widely used in acute migraine, and in some countries, they are also available over-the-counter (OTC). In Sweden, sales have increased for both prescription and OTC triptans. This study aimed to describe current prescribing and utilisation patterns of prescription and OTC triptans in Stockholm, Sweden. Register data from 4759 patients dispensed triptans in 2014 were used to study documented diagnosis of migraine, concomitant acute and preventive treatment for migraine, and contraindications. Survey data from 49 patients purchasing OTC triptans in three pharmacies were used to capture physician-diagnosed migraine, concomitant acute and preventive treatment for migraine, a behaviour of combining or alternating between prescription and OTC triptans, and pharmacy counselling rates. Among the prescription triptan users, 52 % had a recorded diagnosis of migraine, 48 % had no other acute treatment, preventive treatment was rare (12 %) and contraindications were found in 2 % of the patients. Among the OTC triptan users, the majority (63 %) had been diagnosed by a physician and had a history of prescription triptan use, but combining or alternating between OTC and prescription triptans was rare. Concomitant acute treatment was reported in 53 % and preventive treatment was rare (4 %), despite high self-reported migraine frequencies. Some off-label use was detected, despite moderate to high counselling rates. Triptans are prescribed with attention to safety but with poor recording of migraine diagnosis. OTC triptan users generally have a history of prescription triptan use. Preventive treatment rates are low in both groups. Strategies to discern patients who need other treatment options should be considered.

    Keyword
    Triptans, Over-the-counter, OTC, Drug utilisation, Prescription, Survey
    National Category
    Pharmaceutical Sciences
    Identifiers
    urn:nbn:se:uu:diva-298065 (URN)10.1007/s00228-016-2028-y (DOI)000376245600014 ()26922586 (PubMedID)
    Available from: 2016-06-30 Created: 2016-06-29 Last updated: 2018-01-19Bibliographically approved
    4. Competence, competition and collaboration: Perceived challenges among Swedish community pharmacists engaging in pharmaceutical services research
    Open this publication in new window or tab >>Competence, competition and collaboration: Perceived challenges among Swedish community pharmacists engaging in pharmaceutical services research
    (English)Manuscript (preprint) (Other academic)
    Keyword
    community pharmacy, Sweden, cognitive pharmaceutical services, research, patient-centered care
    National Category
    Social and Clinical Pharmacy
    Research subject
    Pharmaceutical Science; Social Pharmacy
    Identifiers
    urn:nbn:se:uu:diva-338726 (URN)
    Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-01-19
  • Schönning, Karin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Future Perspectives on Baryon Form Factor Measurements with BES III2017In: Xiith Quark Confinement And The Hadron Spectrum / [ed] Foka, Y Brambilla, N Kovalenko, V, E D P SCIENCES , 2017, article id UNSP 12002Conference paper (Refereed)
    Abstract [en]

    The electromagnetic structure of hadrons, parameterised in terms of electromagnetic form factors, EMFF's, provide a key to the strong interaction. Nucleon EMFF's have been studied rigorously for more than 60 years but the new techniques and larger data samples available at modern facilities have given rise to a renewed interest for the field. Recently, the access to hyperon structure by hyperon time-like EMFF provides an additional dimension. The BEijing Spectrometer (BES III) at the Beijing Electron Positron Collider (BEPC-II) in China is the only running experiment where time-like baryon EMFF's can be studied in the e(+) e(-) -> BB reaction. The BES III detector is an excellent tool for baryon form factor measurements thanks to its near 4 pi coverage, precise tracking, PID and calorimetry. All hyperons in the SU(3) spin 12 octet and spin 32 decuplet are energetically accessible within the BEPC-II energy range. Recent data on proton and Lambda hyperon form factors will be presented. Furthermore, a world-leading data sample was collected in 2014-2015 for precision measurements of baryon form factors. In particular, the data will enable a measurement of the relative phase between the electric and the magnetic form factors for Lambda and Lambda(+)(c) and hyperons. The modulus of the phase can be extracted from the hyperon polarisation, which in turn is experimentally accessible via the weak, parity violating decay. Furthermore, from the spin correlation between the outgoing hyperon and antihyperon, the sign of the phase can be extracted. This means that the time-like form factors can be completely determined for the first time. The methods will be outlined and the prospects of the BES III form factor measurements will be given. We will also present a planned upgrade

  • Burgi, Matthias
    et al.
    Swiss Fed Res Inst WSL, Res Unit Landscape Dynam, CH-8903 Birmensdorf, Switzerland..
    Bieling, Claudia
    Univ Hohenheim, Societal Transit & Agr 430b, Inst Social Sci Agr, D-70599 Stuttgart, Germany..
    von Hackwitz, Kim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Kizos, Thanasis
    Univ Aegean, Dept Geog, Univ Hill 81100, Mytilene, Greece..
    Lieskovsky, Juraj
    Slovak Acad Sci, Inst Landscape Ecol, Akad 2, Nitra 94910, Slovakia..
    Martin, Maria Garcia
    Univ Freiburg, Nat Conservat & Landscape Ecol, D-79106 Freiburg, Germany..
    McCarthy, Sarah
    Landscape Res Grp Ltd, POB 1482, Oxford OX4 9DN, England..
    Muller, Matthias
    Swiss Fed Res Inst WSL, Res Unit Landscape Dynam, CH-8903 Birmensdorf, Switzerland..
    Palang, Hannes
    Tallinn Univ, Sch Humanities, Ctr Landscape & Culture, EE-10120 Tallinn, Estonia..
    Plieninger, Tobias
    Univ Copenhagen, Dept Geosci & Nat Resource Management, Rolighedsvej 23, DK-1958 Frederiksberg C, Denmark..
    Printsmann, Anu
    Tallinn Univ, Sch Humanities, Ctr Landscape & Culture, EE-10120 Tallinn, Estonia..
    Processes and driving forces in changing cultural landscapes across Europe2017In: Landscape Ecology, ISSN 0921-2973, E-ISSN 1572-9761, Vol. 32, no 11, p. 2097-2112Article in journal (Refereed)
    Abstract [en]

    Context

    Cultural landscapes evolve over time. However, the rate and direction of change might not be in line with societal needs and more information on the forces driving these changes are therefore needed.

    Objectives

    Filling the gap between single case studies and meta-analyses, we present a comparative study of landscape changes and their driving forces based in six regions across Europe conducted using a consistent method.

    Methods

    A LULC analysis based on historical and contemporary maps from the nineteenth and twentieth century was combined with oral history interviews to learn more about perceived landscape changes, and remembered driving forces. Land cover and landscape changes were analysed regarding change, conversions and processes. For all case study areas, narratives on mapped land cover change, perceived landscape changes and driving forces were compiled.

    Results

    Despite a very high diversity in extent, direction and rates of change, a few dominant processes and widespread factors driving the changes could be identified in the six case study areas, i.e. access and infrastructure, political shifts, labor market, technological innovations, and for the more recent period climate change.

    Conclusions

    Grasping peoples’ perception supplements the analyses of mapped land use and land cover changes and allows to address perceived landscape changes. The list of driving forces determined to be most relevant shows clear limits in predictability: Whereas changes triggered by infrastructural developments might be comparatively easy to model, political developments cannot be foreseen but might, nevertheless, leave major marks in the landscape.

  • Public defence: 2018-03-09 10:00 Hamberg, Uppsala
    den Boer, Wendy
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Evolutionary Progression of the Iconic Australasian Kangaroos, Rat-Kangaroos, and their Fossil Relatives (Marsupialia: Macropodiformes)2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The exceptionally diverse macropodiform’s (kangaroos, rat-kangaroos and their fossil allies) currently have a fossil record that spans from the late Oligocene to the Holocene with an Australasian widespread fossil occurence. The origins of the macropodiforms are believed to have been during the Eocene possibly having split from the Phalangeridae. This is largely based on molecular data as there is a complete lack of macropodiform fossil material prior to the late Oligocene leaving the origins of the macropodiforms to be largely speculative. Thus, late Oligocene rat-kangaroo dental fossil elements associated with Palaeopotorous priscus (which shares characteristics observed in both phalangerid and macropodiforms) were examined to get a better insight into the potential origins of the macropodiforms. The results obtained suggested that P. priscus is currently the most basal macropodiform known. Furthermore, due to the absence of adequate macropodiform post-cranial material, the functional eco-morphological interpretation of various macropodiform fossil taxa has been based largely on cranial and dental characteristics. Consequently, the examination of Miocene Balbaridae kangaroo’s (Balbaroo nalima and an untaxonomised balbarid) post-cranial elements was undertaken, suggesting an array of locomotion types (similar to living macropodiforms) and a likely persistent arboreal and quadrupedal lifestyle. In addition, the Pleistocene Protemnodon anak’s post-cranial material are examined, proposing a probable combination of quadrupedal bounding and a slow walking gait alternative to the eminent fast bipedal saltation seen in almost all extant macropodiforms.

    List of papers
    1. A New Species of the Basal "Kangaroo'' Balbaroo and a Re-Evaluation of Stem Macropodiform Interrelationships
    Open this publication in new window or tab >>A New Species of the Basal "Kangaroo'' Balbaroo and a Re-Evaluation of Stem Macropodiform Interrelationships
    Show others...
    2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 11, p. e112705-Article in journal (Refereed) Published
    Abstract [en]

    Exceptionally well-preserved skulls and postcranial elements of a new species of the plesiomorphic stem macropodiform Balbaroo have been recovered from middle Miocene freshwater limestone deposits in the Riversleigh World Heritage Area of northwestern Queensland, Australia. This constitutes the richest intraspecific sample for any currently known basal "kangaroo'', and, along with additional material referred to Balbaroo fangaroo, provides new insights into structural variability within the most prolific archaic macropodiform clade - Balbaridae. Qualitative and metric evaluations of taxonomic boundaries demonstrate that the previously distinct species Nambaroo bullockensis is a junior synonym of B. camfieldensis. Furthermore, coupled Maximum Parsimony and Bayesian phylogenetic analyses reveal that our new Balbaroo remains represent the most derived member of the Balbaroo lineage, and are closely related to the middle Miocene B. camfieldensis, which like most named balbarid species is identifiable only from isolated jaws. The postcranial elements of Balbaroo concur with earlier finds of the stratigraphically oldest balbarid skeleton, Nambaroo gillespieae, and suggest that quadrupedal progression was a primary gait mode as opposed to bipedal saltation. All Balbaroo spp. have low-crowned bilophodont molars, which are typical for browsing herbivores inhabiting the densely forested environments envisaged for middle Miocene northeastern Australia.

    National Category
    Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-240097 (URN)10.1371/journal.pone.0112705 (DOI)000345533200034 ()25409233 (PubMedID)
    Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2018-01-22Bibliographically approved
    2. Is the Fossil Rat-Kangaroo Palaeopotorous pricus the Most Basally Branching Macropodiform?
    Open this publication in new window or tab >>Is the Fossil Rat-Kangaroo Palaeopotorous pricus the Most Basally Branching Macropodiform?
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Earth and Related Environmental Sciences
    Research subject
    Earth Science with specialization in Historical Geology and Palaeontology
    Identifiers
    urn:nbn:se:uu:diva-339580 (URN)
    Available from: 2018-01-21 Created: 2018-01-21 Last updated: 2018-01-31Bibliographically approved
    3. Autopodial Anatomy Elucidate Climbing Ability in Miocene Balbarid 'kangaroos' (Marsupialia, Macropodifromes)
    Open this publication in new window or tab >>Autopodial Anatomy Elucidate Climbing Ability in Miocene Balbarid 'kangaroos' (Marsupialia, Macropodifromes)
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Earth and Related Environmental Sciences
    Research subject
    Earth Science with specialization in Historical Geology and Palaeontology
    Identifiers
    urn:nbn:se:uu:diva-339581 (URN)
    Available from: 2018-01-21 Created: 2018-01-21 Last updated: 2018-01-31Bibliographically approved
    4. Functional Eco-Morphology of the 'Giant Extinct Wallaby' Protemnodon anak from Morwell Local Fauna, Victoria, Australia
    Open this publication in new window or tab >>Functional Eco-Morphology of the 'Giant Extinct Wallaby' Protemnodon anak from Morwell Local Fauna, Victoria, Australia
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Earth and Related Environmental Sciences
    Research subject
    Earth Science with specialization in Historical Geology and Palaeontology
    Identifiers
    urn:nbn:se:uu:diva-339582 (URN)
    Available from: 2018-01-21 Created: 2018-01-21 Last updated: 2018-01-31Bibliographically approved
    5. Systematic Review of the Fossil Macropodiformes (Kangaroo, Rat-Kangaroos, and their Allies)
    Open this publication in new window or tab >>Systematic Review of the Fossil Macropodiformes (Kangaroo, Rat-Kangaroos, and their Allies)
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Earth and Related Environmental Sciences
    Research subject
    Earth Science with specialization in Historical Geology and Palaeontology
    Identifiers
    urn:nbn:se:uu:diva-339583 (URN)
    Available from: 2018-01-21 Created: 2018-01-21 Last updated: 2018-01-31Bibliographically approved
  • Walladbegi, Java
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Gellerstedt, Martin
    Univ West, Trollhättan, Sweden.
    Svanberg, Anncarin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Jontell, Mats
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Innovative intraoral cooling device better tolerated and equally effective as ice cooling2017In: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, no 5, p. 965-972Article in journal (Refereed)
    Abstract [en]

    Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM. Cryotherapy, using ice chips, has been shown to reduce in an efficient manner the severity and extent of OM, although clinical applications are still limited due to several shortcomings, such as adverse tooth sensations, problems with infectious organisms in the water, nausea, and uneven cooling of the oral mucosa. The present proof-of-concept study was conducted to compare the tolerability, temperature reduction, and cooling distribution profiles of an intra-oral cooling device and ice chips in healthy volunteers who did not receive myeloablative treatment, and therefore, did not experience the symptoms of OM. Twenty healthy volunteers used the cooling device and ice chips for a maximum of 60 min each, using a cross-over design. The baseline and final temperatures were measured at eight intra-oral locations using an infra-red thermographic camera. The thermographic images were analysed using two digital software packages. A questionnaire was used to assess the tolerability levels of the two interventions. The intra-oral cooling device was significantly better tolerated than the ice-chips (p = 0.0118). The two interventions were equally effective regarding temperature reduction and cooling distribution. The intra-oral cooling device shows superior tolerability in healthy volunteers. Furthermore, this study shows that temperature reduction and cooling distribution are achieved equally well using either method.

  • Andersson, Matilda
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Levak, Nicholas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Kostintag hos amputerade: En jämförande undersökning av energiintag, mikronutrientsintag och intagsfrekvenser i relation till Riksmaten 2010/20112017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Introduktion: Det finns anledning att tro att amputerade har en ökad risk för både viktuppgång och näringsbrist. Övervikt kan medföra särskilt stora negativa konsekvenser för denna patientgrupp och förutsättningarna för fysisk aktivitet är ofta begränsade. Nutritionsrelaterade problem som kan uppstå efter amputation är ett outforskat ämne och kostintag kan undersökas i jämförelse mot Riksmaten för att bättre förstås.

    Syfte: Att undersöka intag av energi- och mikronutrienter, samt intagsfrekvenser av utvalda livsmedel bland amputerade och att jämföra detta mot resultatet i Riksmaten 2010/2011.

    Metod: Deltagarna rekryterades genom sociala medier, ortopedverkstäder och rehabiliteringscenter runt om i Sverige. Datainsamlingen skedde genom en kostregistrering över fyra dagar och en tillhörande enkät utformad specifikt för amputerade, med Riksmatens material som mall.

    Resultat: Totalt deltog 8 personer i kostregistreringen och 7 deltagare besvarade även enkäten. Energiintaget understeg beräknat energibehov med 30 procent, och var cirka 15 procent lägre än i Riksmaten för båda könen. Flera deltagare nådde inte AR för vitamin D, folat och järn, och intaget av mikronutrienter var överlag lägre bland de amputerade deltagarna.

    Slutsats: Resultatet pekar i linje med ett sänkt energiintag efter amputation men på grund av det lilla antalet deltagare kan inga generaliseringar göras. Det finns anledning att undersöka detta, och intaget av vitamin D i framtida studier.

  • Aaboud, M.
    et al.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for top quark decays t -> qH,with H -> gamma gamma, in root s=13 TeV pp collisions using the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 10, article id 129Article in journal (Refereed)
    Abstract [en]

    This article presents a search for flavour-changing neutral currents in the decay of a top quark into an up-type (q = c; u) quark and a Higgs boson, where the Higgs boson decays into two photons. The proton-proton collision data set analysed amounts to 36.1 fb(-1) at root s = 13TeV collected by the ATLAS experiment at the LHC. Top quark pair events are searched for, where one top quark decays into qH and the other decays into bW. Both the hadronic and leptonic decay modes of the W boson are used. No significant excess is observed and an upper limit is set on the t -> cH branching ratio of 2 : 2 x 10(-3) at the 95% confidence level, while the expected limit in the absence of signal is 1 : 6 x 10(-3). The corresponding limit on the tcH coupling is 0.090 at the 95% confidence level. The observed upper limit on the t -> uH branching ratio is 2 : 4 x 10(-3).

  • Public defence: 2018-03-09 13:15 Häggsalen, Uppsala
    Bengtson, Charlotta
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Quantum Resources for Efficient Excitation Energy Transfer in Natural and Artificial Pigment-Protein Molecular Aggregates2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Recently, long-lasting quantum effects in a number of photosynthetic complexes, which are pigment-protein molecular aggregates (PPMAs), were experimentally verified. These findings created an interest in trying to connect the known highly efficient excitation energy transfer (EET) in these systems to the existence of quantum effects such as quantum coherence and quantum correlations. It also raised the question of how these sensitive quantum effects can survive in such a macroscopic system.

    This thesis explores the existence and possible role of quantum effects in the EET in PPMAs. These systems can be modeled as non-Markovian open quantum systems and quantum effects can be investigated and quantified by methods developed in quantum information theory.

    Firstly, it is found that quantum nonlocal correlations in the EET in the Fenna-Matthews-Olson complex - a PPMA found in nature - are unlikely to exist when the initial excitation occurs in a natural manner. When the initial excitation occurs in an artificial manner by localization of the excitation on one pigment, nonlocal correlations exist on a short time scale. It is further found that in order for nonlocal correlations to be preserved in such a system, the excitation must be trapped on two pigments at the time and these pigments must not interact strongly with other pigments in the complex.

    Secondly, it is shown that quantum coherence is not in general a resource for efficient EET in model systems consisting of a network of pigments; systems optimized with respect to the amount of coherence do not coincide with systems with optimal EET efficiency between two end-site pigments.

    Thirdly, it is found that environmental effects and system-environment interactions can be tuned to optimize the EET efficiency in model PPMAs. The features of optimal environments highly depends on the structure of the pigment system and in particular, the relationship between the pigments excitation energies. It is further shown that a non-Markovian dynamics cannot be connected to an increased EET efficiency in these systems.

    List of papers
    1. Quantum nonlocality in the excitation energy transfer in the Fenna-Matthews-Olson complex
    Open this publication in new window or tab >>Quantum nonlocality in the excitation energy transfer in the Fenna-Matthews-Olson complex
    2016 (English)In: International Journal of Quantum Chemistry, ISSN 0020-7608, E-ISSN 1097-461X, Vol. 116, p. 1763-1771Article in journal (Refereed) Published
    Abstract [en]

    The Fenna-Matthews-Olson (FMO) complex - a pigment protein complex involved in photosynthesis in green sulfur bacteria - is remarkably efficient in transferring excitation energy from light harvesting antenna molecules to a reaction center. Recent experimental and theoretical studies suggest that quantum coherence and entanglement may play a role in this excitation energy transfer (EET). We examine whether bipartite quantum nonlocality, a property that expresses a stronger-than-entanglement form of correlation, exists between different pairs of chromophores in the FMO complex when modeling the EET by the hierarchically coupled equations of motion method. We compare the results for nonlocality with the amount of bipartite entanglement in the system. In particular, we analyze in what way these correlation properties are affected by different initial conditions. It is found that bipartite nonlocality only exists when the initial conditions are chosen in an unphysiological manner and probably is absent when considering the EET in the FMO complex in its natural habitat. It is also seen that nonlocality and entanglement behave quite differently in this system. In particular, for localized initial states, nonlocality only exists on a very short time scale and then drops to zero in an abrupt manner. As already known from previous studies, quantum entanglement between chromophore pairs on the other hand is oscillating and exponentially decaying and follow thereby a pattern more similar to the chromophore population dynamics. The abrupt disappearance of nonlocality in the presence of nonvanishing entanglement is a phenomenon we call nonlocality sudden death; a striking manifestation of the difference between these two types of correlations in quantum systems. 

    Keyword
    Photosynthesis, quantum nonlocality, open quantum systems
    National Category
    Other Physics Topics Theoretical Chemistry
    Research subject
    Physics with specialization in Quantum Chemistry; Biology
    Identifiers
    urn:nbn:se:uu:diva-246119 (URN)10.1002/qua.25221 (DOI)000385587200001 ()
    Funder
    Swedish Research Council, D0413201eSSENCE - An eScience CollaborationSwedish National Infrastructure for Computing (SNIC), snic2014-3-66
    Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2018-01-19Bibliographically approved
    2. Nonlocality in the Fenna-Matthews-Olson complex: Using Nature for learning about nonlocality preservation in a multi-qubit open system
    Open this publication in new window or tab >>Nonlocality in the Fenna-Matthews-Olson complex: Using Nature for learning about nonlocality preservation in a multi-qubit open system
    (English)Manuscript (preprint) (Other academic)
    Keyword
    Quantum nonlocality, Quantum coherence, Open quantum systems
    National Category
    Natural Sciences
    Research subject
    Chemistry with specialization in Quantum Chemistry
    Identifiers
    urn:nbn:se:uu:diva-339463 (URN)
    Available from: 2018-01-18 Created: 2018-01-18 Last updated: 2018-01-19
    3. The role of quantum coherence in dimer and trimer excitation energy transfer
    Open this publication in new window or tab >>The role of quantum coherence in dimer and trimer excitation energy transfer
    2017 (English)In: New Journal of Physics, ISSN 1367-2630, E-ISSN 1367-2630, Vol. 19, article id 113015Article in journal (Refereed) Published
    Abstract [en]

    Recent progress in resource theory of quantum coherence has resulted in measures to quantify coherence in quantum systems. Especially, the l1-norm and relative entropy of coherence have been shown to be proper quantifiers of coherence and have been used to investigate coherence properties in different operational tasks. Since long-lasting quantum coherence has been experimentally confirmed in a number of photosynthetic complexes, it has been debated if and how coherence is connected to the known efficiency of population transfer in such systems. In this study, we investigate quantitatively the relationship between coherence, as quantified by l1 norm and relative entropy of coherence, and efficiency, as quantified by fidelity, for population transfer between end-sites in a network of two-level quantum systems. In particular, we use the coherence averaged over the duration of the population transfer in order to carry out a quantitative comparision between coherence and fidelity. Our results show that although coherence is a necessary requirement for population transfer, there is no unique relation between coherence and the efficiency of the transfer process.

    Keyword
    Quantum coherence, energy transport
    National Category
    Other Physics Topics
    Research subject
    Physics with spec. in Atomic, Molecular and Condensed Matter Physics
    Identifiers
    urn:nbn:se:uu:diva-327295 (URN)10.1088/1367-2630/aa916b (DOI)
    Funder
    Swedish Research Council, D0413201
    Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2018-01-19Bibliographically approved
    4. Environmental design principles for efficient excitation energy transfer in dimer and trimer pigment-protein molecular aggregates and the relation to non-Markovianity
    Open this publication in new window or tab >>Environmental design principles for efficient excitation energy transfer in dimer and trimer pigment-protein molecular aggregates and the relation to non-Markovianity
    (English)In: QuantumArticle in journal (Refereed) Submitted
    Abstract [en]

    Lately there has been an interest in studying the effects and mechanisms of environment-assisted quantum transport, especially in the context of excitation energy transfer (EET) in pigment-protein molecular aggregates. Since these systems can be seen as open quantum systems where the dynamics is within the non-Markovian regime, the effect of non-Markovianity on efficient EET as well as its role in preserving quantum coherence and correlations has also been investigated in recent works. In this study, we explore optimal environments for efficient EET between end sites in a number of dimer and trimer model pigment-protein molecular aggregates when the EET dynamics is modeled by the HEOM-method. For these optimal environmental parameters, we further quantify the non-Markovianity by the BLP-measure to elucidate its possible connection to efficient EET. We also quantify coherence in the pigment systems by means of the measure l1−norm of coherence to analyze its interplay with environmental effects when EET efficiency is maximal. Our aim is to investigate possible environmental design principles for achieving efficient EET in model pigment-protein molecular aggregates and to determine whether non-Markovianity is a possible underlying resource in such systems. We find that the structure of the system Hamiltonian (i.e., the pigment Hamiltonian parameter space) and especially, the relationship between the site excitation energies, determines whether one of two specific environmental regimes is the most beneficial in promoting efficient EET in these model systems. In the first regime, optimal environmental conditions are such that the EET dynamics in the system is left as coherent as possible. In the second regime, the most advantageous role of the environment is to drive the system towards equilibrium as fast as possible. In reality, optimal environmental conditions may involve a combination of these two effects. We cannot establish a relation between efficient EET and non-Markovianity, i.e., non-Markovianity cannot be regarded as a resource in the systems investigated in this study. 

    Keyword
    Excitation energy transfer, Quantum coherence, non-Markovianity
    National Category
    Natural Sciences
    Research subject
    Chemistry with specialization in Quantum Chemistry
    Identifiers
    urn:nbn:se:uu:diva-339462 (URN)
    Available from: 2018-01-18 Created: 2018-01-18 Last updated: 2018-02-18
  • Soares Oliveira, Thaís
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Businesses, the UN and decent work promotion: a case study of H&M, ILO and Sida’s engagement in Cambodia2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Some retail companies have been facing boycotts and negative criticism due to their association with sweatshop practices and human rights scandals. In order to deal with such criticism, it has become common for these garment sector businesses to implement corporate responsibility projects in countries in which their independent suppliers are located. These projects fall within the Sustainable Development Goals (SDGs) framework, more specifically on how the private sector can contribute to the achievement of the 8th goal, which is related to decent work and economic growth. In this sense, this work analyzes how the understanding of problems related to work processes influence the design and outcome of an initiative partially implemented by the private sector. A project implemented in Cambodia by H&M, the International Labour Organization (ILO) and the Swedish International Development Cooperation Agency (Sida) was used as case study. 

  • Abbott, B. P.
    et al.
    CALTECH, LIGO, Pasadena, CA 91125 USA.
    Botner, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Burgman, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Hallgren, Allan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pérez de los Heros, Carlos
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Unger, Elisabeth
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Woudt, P. A.
    Univ Cape Town, Dept Astron, Astrophys Cosmol & Grav Ctr, Private Bag X3, ZA-7701 Rondebosch, South Africa.
    Multi-messenger Observations of a Binary Neutron Star Merger2017In: Astrophysical Journal Letters, ISSN 2041-8205, E-ISSN 2041-8213, Vol. 848, no 2, article id L12Article in journal (Refereed)
    Abstract [en]

    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 . An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient's position and days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.

  • Stahl, Thomas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    MSF and the Hippocratic Approach: a single case study on communication in the conflict of South Sudan2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates Médécins Sans Frontières (MSF) communication in the setting of South Sudan. More precisely, the thesis investigates MSF’s engagement in a discussion regarding the potential harm NGOs, both other and themselves, might cause in terms of conflict dynamics. The thesis takes off in the perceived conflict between the adaptation of the Hippocratic Approach, as outlined by Mary B Anderson, and the increased necessity of branding in today’s humanitarian industry and seeks to understand how this might unfold in practice. Demonstrating MSF’s commitment to ideals in line with the Hippocratic Approach, which encourage self-criticism and accountability, the thesis moves on to illustrate how branding has become an inevitable measure for NGOs to remain operational. Based on previous research identifying a successful branding as information, trust and image, where self-criticism might be counter-productive, the thesis tries to identify the conflict between the two fields. The thesis sets out to uncover some of the tensions more concretely by investigating MSF’s communication in the conflict-settings of South Sudan. It does so utilizing the method Qualitative Content Analysis. The material stems from MSF’s self-published reports, reviews and articles. In conclusion, the thesis finds that MSF does engage in a discussion about harms caused by other organizations as well as harm caused by themselves. However, the harms discussed are not put in terms of conflict dynamics in South Sudan. Furthermore, the thesis identifies some disproportion in criticism towards other organizations versus self-criticism. The thesis refrains from drawing any permanent conclusions and suggest a comparative case study to better understand the tensions in NGO’s building of a Hippocratic brand. 

  • Ripe, Linnea
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Söderström, Gustaf
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Ägarstrukturens påverkan på bolagets CSR-prestation: En kvantitativ studie över svenska börsbolag.2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Corporate Social Responsibility (CSR) har ägnats substantiell uppmärksamhet bland lagstiftare, akademiker och praktiker. Samhället ställer idag allt högre krav på företagens hållbarhetsarbete. Det huvudsakliga intresset har varit de olika drivkrafterna bakom CSR, där en potentiell determinant är företagens ägarstruktur. Tidigare forskning indikerar attf öretagens ägarstruktur är relaterat till företagens CSR-prestation. Denna studie undersöker huruvida ägarkoncentration, familjeägande samt institutionellt ägande påverkar företagens CSR-prestation i Sverige. Studien, (med en deduktiv ansats) vars teoretiska grund utgår ifrån agentteorin, använder detaljerad ägardata över svenska börsnoterade företag och Folksams Index för hållbart företagande används som mått på företagens CSR-prestation. Urvalet består av 718 företagsår från svenska börsnoterade företag för åren 2007, 2009, 2011 och 2013. Studiens empiriska resultat indikerar ett positivt signifikant samband mellan ägarkoncentration och CSR-prestation samt mellan familjeägande och CSR-prestation. Vidi nteraktionen mellan familjeägande och röstdifferentierade aktier föreligger ett signifikant negativt samband med CSR-prestation. Inget signifikant samband kunde påvisas för institutionellt ägande. Regressionsmodellerna kontrollerar för företagets storlek, lönsamhet, skuldsättning samt fasta effekter för bransch och år. Vårt resultat ger indikationer på att ägarstrukturen är av betydelse för företagens CSR-prestation.

  • Huber, Alexander
    et al.
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Sergienko, Gennady
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Kinna, David
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Huber, Valentina
    Forschungszentrum Julich, Supercomp Ctr, D-52425 Julich, Germany..
    Milocco, Alberto
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England.;Univ Milano Bicocca, Piazza Sci 3, I-20126 Milan, Italy..
    Mercadier, Laurent
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Balboa, Itziar
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Conroy, Sean
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Cramp, Simon
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Kiptily, Vasili
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Kruezi, Uron
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Lambertz, Horst Toni
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Linsmeier, Christian
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Matthews, Guy
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Popovichev, Sergey
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Mertens, Philippe
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Silburn, Scott
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Zastrow, Klaus-Dieter
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Response of the imaging cameras to hard radiation during JET operation2017In: Fusion engineering and design, ISSN 0920-3796, E-ISSN 1873-7196, Vol. 123, p. 669-673Article in journal (Refereed)
    Abstract [en]

    The analysis of the radiation damage of imaging systems is based on all different types-of aiialoiue/digital cameras with uncooled as well as actively cooled image sensors in the VIS/NIR/MWIR spectral ranges. The Monte Carlo N-Particle (MCNP) code has been used to determine the neutron fluence at different camera locations in JET. An explicit link between the sensor damage and the neutron fluence has been observed. Sensors show an increased dark-current and increased numbers of hot-pixels. Uncooled cameras must be replaced once per year after exposure to a neutron fluence of similar to 1.9-3.2 x 10(12)neutrons/cm(2). Such levels of fluence will be reached after approximate to 14-22 ELMy H-mode pulses during the future D-T campaign. Furthermore, dynamical noise seen as a random pattern of bright pixels was observed in the presence of hard radiation (neutrons and gammas). Failure of the digital electronics inside the cameras as well as of industrial controllers is observed beyond a neutron fluence of about similar to 4 x 10(9) neutrons/cm(2). The impact of hard radiation on the different types of electronics and possible application of cameras during future D-T campaign is discussed.

  • Book, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, FREIA.
    1kW Class-E solid state power amplifier for cyclotron RF-source2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis discusses the design, construction and testing of a highefficiency, 100 MHz, 1 kW, Class-E solid state power amplifier. The design was performed with the aid of computer simulations using electronic design software (ADS). The amplifier was constructed around Ampleon's BLF188XR LDMOS transistor in a single ended design. The results for 100 MHz operation show a power added efficiency of 82% at 1200 W pulsed power output. For operation at 102 MHz results show a power added efficiency of 86% at 1050 W pulsed power output. Measurements of the drain- and gate voltage waveforms provide validation of Class-E operation.

  • Alberius, Adam
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Lundin, Martin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media, Media and Communication Studies.
    Coops hållbarhetsarbete: En fallstudie om hur ett ord kan påverka organisationskulturen2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In the light of corporate scandals, pressure has increased on organizations to communicate

    information related to their corporate social responsibility (CSR). In order to keep up with the

    increased pressure on social commitment, organizations’ self-descriptions may be future-oriented

    rather than reflections of reality. The future-oriented communication may improve the

    organizational culture and thereby motivate staff to perform more efficiently. On the other hand,

    if the organization does not fulfill their CSR communication it could lead to internal skepticism.

    This thesis constitutes a case study of the organization Coop, comprising whether the

    relationship between its CSR communication and the internal perception of Coop’s CSR work

    in store has affected their organizational culture.

     

    In order to answer How does Coop communicate it sustainability work through its external

    communication? and How does the staff perceive Coop's sustainability work? a qualitative

    content analysis and interviews with Coop’s staff have been conducted. The theoretical

    framework consists of Nils Brunsson’s (2006) theory about Organized hypocrisy, and

    Christensen's (1997) Autocommunication.

     

    A conclusion that can be made from the results of this thesis, is that the image communicated

    from Coop (regarding their sustainability work) does not seem to be fully aligned with the

    staff’s perception of Coop’s sustainability work. Coop’s definition of their sustainability work

    had only been acknowledged by some, whereas half of the staff had individual interpretations

    of Coop’s sustainability work. The various definitions of sustainability among the staff led to

    various attitudes towards Coop’s sustainability work, which ultimately resulted in a fragmented

    organizational culture.

  • Gustafsson, Sofia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Lindström, Veronica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Ingelsson, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Hammarlund-Udenaes, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Syvänen, Stina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology2018In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 128, p. 482-491Article in journal (Refereed)
    Abstract [en]

    Pathophysiological impairment of the neurovascular unit, including the integrity and dynamics of the blood-brain barrier (BBB), has been denoted both a cause and consequence of neurodegenerative diseases. Pathological impact on BBB drug delivery has also been debated. The aim of the present study was to investigate BBB drug transport, by determining the unbound brain-to-plasma concentration ratio (K-p,K-uu,K-brain), in aged A beta PP-transgenic mice, alpha-synuclein transgenic mice, and wild type mice. Mice were dosed with a cassette of five compounds, including digoxin, levofloxacin (1 mg/kg, s.c.), paliperidone, oxycodone, and diazepam (0.25 mg/kg, s.c.). Brain and blood were collected at 0.5,1, or 3 h after dosage. Drug concentrations were measured using LC-MS/MS. The total brain-to-plasma concentration ratio was calculated and equilibrium dialysis was used to determine the fraction of unbound drug in brain and plasma for all compounds. Together, these three measures were used to determine the Kp,uu,brain value. Despite A beta or alpha-synuclein pathology in the current animal models, no difference was observed in the extent of drug transport across the BBB compared to wild type animals for any of the compounds investigated. Hence, the present study shows that the concept of a leaking barrier within neurodegenerative conditions has to be interpreted with caution when estimating drug transport into the brain. The capability of the highly dynamic BBB to regulate brain drug exposure still seems to be intact despite the presence of pathology. (C) 2017 The Authors. Published by Elsevier Ltd.

  • Nyhlin, Jakob
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Stålberg, Samuel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Träningsmotivation genom spelifiering: Baserat på övrigt spelande i vardagen2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I denna studie undersöks effekten av spelifiering på människors träningsmotivation i förhållande till om de spelar dator-, tv- eller mobilspel regelbundet eller inte. Undersökningen genomfördes med hjälp av två testgrupper baserade på testpersonernas spelvanor. Dessa två grupper fick under tio dagar testa en egenutvecklad träningsapplikationsprototyp med fokus på spelifieringselement. Prototypens utformning framställdes med hjälp av forskningsstrategin Design Science och var baserad på tidigare forskning och teorier inom området. Målet med studien var att undersöka om det fanns någon skillnad i motivationsnivå mellan de två testgrupperna och om det fanns spelifieringselement som upplevdes som särskilt motiverande för testpersonerna. Undersökningens resultat visade att det fanns en viss skillnad mellan de två testgrupperna, där människor som spelade regelbundet upplevde prototypens spelifieringselement som mer motiverande än de som inte spelade regelbundet. Skillnaden var dock inte stor nog för att enligt oss dra några större slutsatser utifrån. De element som upplevdes som mest positiva skilde sig mellan testgrupperna. Det som ansågs motivera mest var nivåer för spelare och topplistan för icke-spelare

  • Polydorou, Konstantina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Rocén, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Zabzine, Maxim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    7D supersymmetric Yang-Mills on curved manifolds2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 152Article in journal (Refereed)
    Abstract [en]

    We study 7D maximally supersymmetric Yang-Mills theory on curved manifolds that admit Killing spinors. If the manifold admits at least two Killing spinors (Sasaki-Einstein manifolds) we are able to rewrite the supersymmetric theory in terms of a cohomological complex. In principle this cohomological complex makes sense for any K-contact manifold. For the case of toric Sasaki-Einstein manifolds we derive explicitly the perturbative part of the partition function and speculate about the non-perturbative part. We also briefly discuss the case of 3-Sasaki manifolds and suggest a plausible form for the full non-perturbative answer.

  • Binda, Federico
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Ericsson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Conroy, Sean
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Andersson Sundén, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Calculation of the profile-dependent neutron backscatter matrix for the JET neutron camera system2017In: Fusion engineering and design, ISSN 0920-3796, E-ISSN 1873-7196, Vol. 123, p. 865-868Article in journal (Refereed)
    Abstract [en]

    We investigated the dependence of the backscatter component of the neutron spectrum on the emissivity profile. We did so for the JET neutron camera system, by calculating a profile-dependent backscatter matrix for each of the 19 camera channels using a MCNP model of the JET tokamak. We found that, when using a low minimum energy for the summation of the counts in the neutron pulse height spectrum, the backscatter contribution can depend significantly on the emissivity profile. The maximum variation in the backscatter level was 24% (8.0% when compared to the total emission). This effect needs to be considered when a correction for the backscatter contribution is applied to the measured profile.

  • Finné, Martin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history. Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece..
    Holmgren, Karin
    Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece.;Swedish Univ Agr Sci, Uppsala, Sweden..
    Shen, Chuan-Chou
    Natl Taiwan Univ, High Precis Mass Spectrometry & Environm Change L, Dept Geosci, Taipei, Taiwan..
    Hu, Hsun-Ming
    Natl Taiwan Univ, High Precis Mass Spectrometry & Environm Change L, Dept Geosci, Taipei, Taiwan..
    Boyd, Meighan
    Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece.;Royal Holloway Univ London, Dept Earth Sci, Egham, Surrey, England..
    Stocker, Sharon
    Univ Cincinnati, Dept Class, 410 Blegen Lib, Cincinnati, OH USA..
    Late Bronze Age climate change and the destruction of the Mycenaean Palace of Nestor at Pylos2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 12, article id e0189447Article in journal (Refereed)
    Abstract [en]

    This paper offers new high-resolution oxygen and carbon isotope data from Stalagmite S1 from Mavri Trypa Cave, SW Peloponnese. Our data provide the climate background to the destruction of the nearby Mycenaean Palace of Nestor at Pylos at the transition from Late Helladic (LH) IIIB to LH IIIC, similar to 3150-3130 years before present (before AD 1950, hereafter yrs BP) and the subsequent period. S1 is dated by 24 U-Th dates with an averaged precision of +/- 26 yrs (2s), providing one of the most robust paleoclimate records from the eastern Mediterranean for the end of the Late Bronze Age (LBA). The delta O-18 record shows generally wetter conditions at the time when the Palace of Nestor at Pylos was destroyed, but a brief period of drier conditions around 3200 yrs BP may have disrupted the Mycenaean agricultural system that at the time was likely operating close to its limit. Gradually developing aridity after 3150 yrs BP, i.e. subsequent to the destruction, probably reduced crop yields and helped to erode the basis for the reinstitution of a central authority and the Palace itself.

  • Atterby, Clara
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Börjesson, Stefan
    Natl Vet Inst SVA, Dept Anim Hlth & Antimicrobial Strategies, Uppsala, Sweden..
    Ny, Sofia
    Publ Hlth Agcy Sweden, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Stockholm, Sweden..
    Järhult, Josef D.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Byfors, Sara
    Publ Hlth Agcy Sweden, Stockholm, Sweden..
    Bonnedahl, Jonas
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, Kalmar, Sweden.;Kalmar Cty Council, Dept Infect Dis, Kalmar, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    ESBL-producing Escherichia coli in Swedish gulls: A case of environmental pollution from humans?2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 12, article id e0190380Article in journal (Refereed)
    Abstract [en]

    ESBL-producing bacteria are present in wildlife and the environment might serve as a resistance reservoir. Wild gulls have been described as frequent carriers of ESBL-producing E. coli strains with genotypic characteristics similar to strains found in humans. Therefore, potential dissemination of antibiotic resistance genes and bacteria between the human population and wildlife need to be further investigated. Occurrence and characterization of ESBL-producing E. coli in Swedish wild gulls were assessed and compared to isolates from humans, livestock and surface water collected in the same country and similar time-period. Occurrence of ESBL-producing E. coli in Swedish gulls is about three times higher in gulls compared to Swedish community carriers (17% versus 5%) and the genetic characteristics of the ESBL-producing E. coli population in Swedish wild gulls and Swedish human are similar. ESBL-plasmids IncF-and IncI1-type carrying ESBL-genes blaCTX-M-15 or blaCTX-M-14 were most common in isolates from both gulls and humans, but there was limited evidence of clonal transmission. Isolates from Swedish surface water harbored similar genetic characteristics, which highlights surface waters as potential dissemination routes between wildlife and the human population. Even in a low-prevalence country such as Sweden, the occurrence of ESBL producing E. coli in wild gulls and the human population appears to be connected and the occurrence of ESBL-producing E. coli in Swedish gulls is likely a case of environmental pollution.

  • Beyer, Gabriel Andersson
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Theses, de certitudine morali, quas, ex consensu amplissimi senatus philosophici, in alma academia regia Upsaliensi, candido bonorum examini modeste subjiciunt auctor, Gabriel Andersson Beyer ... & respondens, Daniel Aurelius, Joan. fil. Gothoburgenses. In audit. Gustaviano, ad d. XI. Junii. Anno MDCCXLVIII. H. a. m. s.1748Dissertation (older thesis) (Other academic)
  • Bexell, Justus Gabriel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    De conformitate conjugationis Arabicæ atque Hebrææ dissertatio, posteriorem cujus partem, venia ampl. ord. philos. Upsal. p. p. mag. Justus G. Bexell ... et Adamus Rosenblad, stip. reg. Uplandus. In audit. Gustav. die V Dec. MDCCCXII. H. p. m. s., P. 21812Dissertation (older thesis) (Other academic)
  • Bexell, Justus Gabriel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    De conformitate conjugationis Arabicæ atque Hebrææ dissertatio, priorem cujus partem, venia ampl. ord. philos. Upsal. p. p. mag. Justus G. Bexell ... et Johannes Gust. Wretberg, stip. reg. Uplandus. In audit. Gustav. die V Dec. MDCCCXII. H. a. m. s., P. 11812Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University.
    Notæ criticæ, in jus ecclesiasticum Vicensium, vulgo, Cristinrettr Vicveria, dictum, quarum partem primam, consent. ampliss. senatu academ. publico examini submittunt, auctor, Magnus Olavus Beronius ... et respondens Magnus Nyman, Isr. fil Uplandi. H. a. m. s. in audit. Carol maj. d. XXVII. Maji anni MDCCLXI.1761Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Diatriben academicam de exorcismo baptismali, a venerando theologorum Upsalensium ordine comprobatam, moderatore ... Magno Beronio ... examini publico subjicit auctor, stipendiarius Zedritzianus, Johannes J. Amnell, Uplandus; idque in acroat. Gustav. maj. ad. d. IX. Decembr. Horis antemeridianis.1738Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Dissertatio theologica aphorismos nonnullos selectos circa orationem dominicam exhibens, quam, approbante max. ven. facult. theolog. in reg. acad. Upsaliensi, præside ... Magno Beronio ... publico bonorum examini modeste submittit Johannes Kempe, fil. Uplandus, in audit. Carol. major. die VII. Octobr. anni MDCCXXXVIII. Horis ante meridiem consuetis.1738Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertationis philosophicæ, de vitiis quibusdam poëtantium, quæ, hoc ævo, pædantismi et charlataneriæ nomine venire solent, partem priorem, cum consensu ampliss. facult. philosoph. in reg. academ. Upsalensi, præside ... Magno Beronio ... publico bonorum examini modeste subjicit Olavus O. Celsius, Uplandus. In audit. Gustav. majori ad d. 26 Februarii, anno M DCC XXXVII. Horis ante meridiem solitis.1737Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio academica, de Eddis Islandicis, seu veterum septemtrionalium mythologiis, cujus partem priorem, consentiente ampliss. facultate philosophica in regia academia Vpsaliensi, præside ... mag. Magno Beronio ... publicæ bonorum censuræ submittit Olavus O. Nording, Angermannus. In audit. Gustav. majori, d. XI. Decemb. an. MDCCXXXV. Horis ante meridiem solitis.1735Dissertation (older thesis) (Other academic)
  • Beronius, Magnus Olai
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de usu poëseos, quam consentiente ampliss. facultate philosophica in regia academia Upsaliensi, præside ... Magno Beronio ... publicæ bonorum censuræ submittit s:æ r:æ m:tis alumnus Georgius Werner, Calmariensis. Ad. d. 30. Aprilis anni MDCCXXXV, in audit. Gust. majori. Horis ante meridiem consvetis.1735Dissertation (older thesis) (Other academic)
  • Lange, Martin
    et al.
    Ctr European Econ Res ZEW, POB 10 34 43, D-68034 Mannheim, Germany..
    Pfeiffer, Friedhelm
    Ctr European Econ Res ZEW, POB 10 34 43, D-68034 Mannheim, Germany.;Univ Mannheim, Mannheim, Germany..
    van den Berg, Gerard J.
    Uppsala University, Units outside the University, Office of Labour Market Policy Evaluation. Univ Bristol, Bristol, Avon, England..
    Integrating young male refugees: initial evidence from an inclusive soccer project2017In: JOURNAL FOR LABOUR MARKET RESEARCH, ISSN 2510-5019, Vol. 51, no 1, article id 6Article in journal (Refereed)
    Abstract [en]

    This study analyses data collected among a group of young male refugees who participated in a randomised experiment. Refugees were randomly assigned to a soccer project aimed at facilitating social and labour market integration or to a control group. We evaluate the randomisation process, discuss the design and implementation of the survey and summarize the main findings of the survey by focusing on labour market activity, pre-migration characteristics, and the monetary costs of the escape. In addition, we provide a preliminary outlook on the effectiveness of the programme.

  • Boman, Jesper
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Genome size and phenotypic plasticity in the seed beetle, Callosobruchus maculatus2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    It has long been evident that genome size is not an accurate measure of organismal complexity. This paradox was “solved” with the discovery of nonfunctional and selfish DNA in the 1970s. However, emerging from this explanation was an enigma of complexity. Neither neutral nor adaptive models can account for all genome size variation across the tree of life. An organism with intraspecific variation is needed to investigate the functional role of genome size differences. Here I use different populations of the seed beetle, Callosobruchus maculatus, with a known intraspecific genome size variation of ~4%. It has previously been shown that a larger genome is associated with higher scores in fitness-related traits for this species. In this study, genome size is regressed with phenotypic plasticity along three different environmental gradients. Genome size did not correlate with plasticity in mass and development time along environmental gradients of temperature and host types. However, the results show that larger genomes are consistent with higher canalization of fitness under different food regimes. This further supports the idea that natural selection acts on genome size variation in this species. 

  • Aaboud, M.
    et al.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of inclusive and differential cross sections in the H -> ZZ* -> 4l decay channel in pp collisions at root s=13 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, article id 132Article in journal (Refereed)
    Abstract [en]

    Inclusive and differential fiducial cross sections of Higgs boson production in proton-proton collisions are measured in the H -> Z Z* -> 4l decay channel. The proton-proton collision data were produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb(-1). The inclusive fiducial cross section in the H -> Z Z* -> 4l decay channel is measured to be 3.62 +/- 0.50 (stat) (+0.25)(-0.20) (sys) fb, in agreement with the Standard Model prediction of 2.91 +/- 0.13 fb. The cross section is also extrapolated to the total phase space including all Standard Model Higgs boson decays. Several differential fiducial cross sections are measured for observables sensitive to the Higgs boson production and decay, including kinematic distributions of jets produced in association with the Higgs boson. Good agreement is found between data and Standard Model predictions. The results are used to put constraints on anomalous Higgs boson interactions with Standard Model particles, using the pseudo-observable extension to the kappa-framework.