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  • Arikan, Tuba
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Kucukgöl, Ebru
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Dubbelliv i hederns namn: En kvalitativ studie om HBT-personer i en hederskontext2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract: It has been put on the spotlight and a known fact in Sweden, individuals who live in different honor cultures are exposed to different types of honor oppression. However, there is still very little information about HBT-individuals who live in an honor culture environment and are exposed to honor oppression. The purpose of this study is to create a profound understanding in the HBT-individuals’ experiences with honor and their experiences with identity as HBT-individuals in relation to the honor culture they live in. The study also looks at the possibilities and limitations these individuals mustface every day or at certain times as HBT-individuals in an honor environment. A qualitative method was used throughout the study and the empirical material is based on interviews we made with seven informers. We have used two different interview methods to receive empirical results. The first method is based on a face-to-face interview and the second method is based on chat interviews online. The analysis was examined along the theoretical efforts we used throughout this study such as, social control, honor culture, identity and many more. The results indicate that these informants are at a higher risk of being exposed to different things, such as for example being rejected by their family if they chose to come out and live openly about their sexual identity and not follow the hetero norm that is put in place.

  • Public defence: 2017-12-14 09:15 A1:107a, Uppsala
    Lundstedt, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Development of Mild Methods for Selective Covalent Functionalization of Graphene2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis discusses methods for the comparatively mild covalent functionalization of graphene. Several graphene models were investigated: polycyclic aromatic hydrocarbons (PAHs), chemical vapor deposition (CVD)-graphene on SiO2/Si substrate, graphite foil, graphite flakes, kish graphite and highly oriented pyrolytic graphite. The PAHs were viewed as graphene edge analogs with the following molecules representing different edge motifs: pyrene, perylene, benzo[a]pyrene, benzo[e]pyrene, triphenylene, acenapthylene, and anthracene.

    Ozone was used in combination with different solvents to functionalize PAHs, graphite, and CVD-graphene on SiO2/Si. Ozonation in water or methanol resulted in trapping of the carbonyl oxide intermediate that was formed in the reaction, producing a variety of functional groups. Ozonation in hydrogen peroxide solution with sonication promoted radical formation, possibly resulting in edge-oxidation of graphite. The regioselectivity for addition reactions (ozonolysis) and electrophilic aromatic substitution reactions with graphene edges is discussed.

    To achieve functionalization of the basal plane of graphite or graphene, white light irradiation was used in combination with several transfer hydrogenation reagents. Formic acid treatment under irradiation resulted in the expected hydrogenation, whereas iso-propanol treatment resulted in iso-propanol attachment to the graphene.

    The developed methods provide opportunities for graphene functionalization without the need for metal based reagents or harsh conditions.

    List of papers
    1. Ozonolysis of triphenylene in acetone
    Open this publication in new window or tab >>Ozonolysis of triphenylene in acetone
    (English)Manuscript (preprint) (Other academic)
    National Category
    Organic Chemistry
    Research subject
    Chemistry with specialization in Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-332003 (URN)
    Available from: 2017-10-20 Created: 2017-10-20 Last updated: 2017-10-24
    2. Ozonolysis of polycyclic aromatic hydrocarbons in participating solvents
    Open this publication in new window or tab >>Ozonolysis of polycyclic aromatic hydrocarbons in participating solvents
    2017 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, no 10, 6152-6159 p.Article in journal (Refereed) Published
    Abstract [en]

    Seven polycyclic aromatic hydrocarbon (PAH) compounds that can be considered small models for graphene edges have been treated with ozone in solution. The presence of participating solvents such as water or methanol had a pronounced influence on conversion and identity of the functional groups formed, whereas the regioselectivity of the ozonation remained unaffected. Six previously unreported compounds have been isolated from the ozonolysis of pyrene 1, perylene 2 and benzo[e] pyrene 4. Comparison of the experimental data with calculated local ionization energy surfaces (IES) shows a good correlation, and indicates that this computational tool would be useful to predict the regioselectivity of ozone also for larger PAHs, including graphene and graphene nanoribbons.

    National Category
    Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-316964 (URN)10.1039/c6ra26248a (DOI)000393754100073 ()
    Funder
    Swedish Research CouncilKnut and Alice Wallenberg Foundation
    Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2017-10-24Bibliographically approved
    3. Edge oxidation of graphite using a combined hydrogen peroxide - ozone treatment under sonication conditions
    Open this publication in new window or tab >>Edge oxidation of graphite using a combined hydrogen peroxide - ozone treatment under sonication conditions
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    A mild method for edge oxidation of graphite using ultrasonication in the presence of ozone and hydrogen peroxide is described. The method benefits from sustainable reagents - no metals or oxidising mineral acids are involved; and easy purification of the resulting material. Initial characterisation of the material and its dispersibility by spectroscopic methods and thermogravimetric analysis is presented.

    Keyword
    Edge oxidation, Graphite, Graphene, Hydrogen peroxide, Ozone
    National Category
    Materials Chemistry Organic Chemistry
    Identifiers
    urn:nbn:se:uu:diva-327165 (URN)
    Available from: 2017-08-06 Created: 2017-08-06 Last updated: 2017-10-24
    4. Metal-free photochemical silylations and transfer hydrogenations of benzenoid hydrocarbons and graphene
    Open this publication in new window or tab >>Metal-free photochemical silylations and transfer hydrogenations of benzenoid hydrocarbons and graphene
    Show others...
    2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723Article in journal (Refereed) Published
    Abstract [en]

    The first hydrogenation step of benzene, which is endergonic in the electronic ground state (S0), becomes exergonic in the first triplet state (T1). This is in line with Baird’s rule, which tells that benzene is antiaromatic and destabilized in its T1 state and also in its first singlet excited state (S1), opposite to S0, where it is aromatic and remarkably unreactive. Here we utilized this feature to show that benzene and several polycyclic aromatic hydrocarbons (PAHs) to various extents undergo metal-free photochemical (hydro)silylations and transfer-hydrogenations at mild conditions, with the highest yield for naphthalene (photosilylation: 21%). Quantum chemical computations reveal that T1-state benzene is excellent at H-atom abstraction, while COT, aromatic in the T1 and S1 states according to Baird’s rule, is unreactive. Remarkably, also CVD-graphene on SiO2 is efficiently transfer-photohydrogenated using formic acid/water mixtures together with white light or solar irradiation under metal-free conditions.

    National Category
    Chemical Sciences Chemical Engineering
    Identifiers
    urn:nbn:se:uu:diva-303639 (URN)10.1038/ncomms12962 (DOI)000385553900001 ()27708336 (PubMedID)
    Funder
    Wenner-Gren FoundationsSwedish Research CouncilKnut and Alice Wallenberg FoundationÅForsk (Ångpanneföreningen's Foundation for Research and Development)Magnus Bergvall Foundation
    Available from: 2016-09-21 Created: 2016-09-21 Last updated: 2017-11-21Bibliographically approved
    5. White-light photoassisted covalent functionalization of graphene using 2-propanol
    Open this publication in new window or tab >>White-light photoassisted covalent functionalization of graphene using 2-propanol
    Show others...
    2017 (English)In: Small Methods, ISSN 2366-9608, 1700214- p.Article in journal (Refereed) Published
    Abstract [en]

    Herein, a photochemical method for functionalization of graphene using 2-propanol is reported. The functionalization method which is catalyst-free operates at ambient temperature in neat 2-propanol under an inert atmosphere of argon. The equipment requirement is a white-light source for the irradiation. The same methodology when applied to kish graphite results in a novel material, exhibiting significantly higher wettability than the starting material according to water contact angle measurements. Furthermore, the materials generated from both graphene and kish graphite exhibit increased adhesion energy, attributed to the fixation of isopropyl alcohol fragments onto graphene and graphite, respectively. The presence of hydroxyl groups and the possibility for further reactions on the functionalized graphene material are demonstrated through a substitution reaction with thionyl chloride, where the hydroxyl groups are replaced with chlorides, as confirmed through X-ray photoelectron spectroscopy analysis.

    Place, publisher, year, edition, pages
    John Wiley & Sons, 2017
    National Category
    Materials Engineering Materials Chemistry
    Identifiers
    urn:nbn:se:uu:diva-314171 (URN)10.1002/smtd.201700214 (DOI)
    Available from: 2017-01-29 Created: 2017-01-29 Last updated: 2017-10-24
  • Public defence: 2017-12-12 13:15 Hörsal 2, Uppsala
    Crawford, Jason
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Regulation's Influence on Risk Management and Management Control Systems in Banks2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation explores regulation’s influence on risk management and management control systems (MCS) in banks. The dissertation comprises of an introductory chapter, two published book chapters, one of which is an extensive literature review, and two working papers, presented at several European conferences. The overall objective of this dissertation is to explore how banks are responding to banking regulation in light of the 2007-08 financial crisis and what the implications of those responses are, particularly in relation to risk management and MCS, and their interactions. The overall research question is therefore: what influence does regulation have on risk management and management control systems in banks over time? The intended ambition is to contribute to existing knowledge on the relationship between bank regulation, risk management, and MCS by providing several practical and theoretical contributions. The dissertation employs an adapted theoretical framework and uses institutional theory and contingency theory to expose tensions between, the demands for uniformity residing in banking regulation, and the demands for uniqueness residing inside banks themselves as they seek to maintain control over the design and use of their organizational controls. The empirical material used in the longitudinal case study is gathered from a large European bank. The main findings of the dissertation are as follows. In Paper I, the findings show that banking regulation’s influence on risk management and management control is mixed, which in turn can influence risk management’s integration with MCS. The paper also finds that very little knowledge exists about regulation’s influence on risk management and MCS. In Paper II, the findings show that while regulatory influence in IT control has increased over time, banks continue to exercise significant influence over regulatory demands. In Paper III, the findings show how regulation’s influence varies considerably over time and that increased regulatory pressure can lead to a higher degree of integration between risk management and MCS across the three dimensions of integration. In Paper IV, the findings show how regulation’s influence is shaping the mental processes of management and employees, and can vary significantly based on several identified factors.

    List of papers
    1. Risk Management and Management Control Systems Integration in Banks: The Role of Regulation and Strategy
    Open this publication in new window or tab >>Risk Management and Management Control Systems Integration in Banks: The Role of Regulation and Strategy
    2017 (English)Conference paper, Oral presentation only (Refereed)
    Abstract [en]

    The rise and expansion of risk management in banks in the last two decades have had a profound impact. New processes, tools, and IT systems have been introduced aimed at enhancing internal control, information quality as well as reporting and disclosure practices. These regulatory derived developments would suggest that risk management’s relationship with management control systems as part of the ‘control package’ is strengthening. Despite the growing number of academic publications, we still know very little about the degree of risk management’s integration with management controls. This paper addresses this gap by examining how and why regulation and strategy influence the degree of risk management’s integration with management control over time and across three integrating dimensions first presented by Gond et al. (2012). Using empirical evidence from a case study of a large European bank, we show movements between control configurations as well as changes in the relationship between the three dimensions over time. In addition we offer the reader deep empirical descriptions of the challenges associated with integrating risk management as part of the wider control package in a banking context. Finally, we explain how our findings can be used in future research to further explore the integration of risk management and management control systems in light of continually evolving regulatory demands and strategic goals. 

    Keyword
    Integration, management control systems, package, regulation, risk management, strategy
    National Category
    Business Administration
    Research subject
    Business Studies
    Identifiers
    urn:nbn:se:uu:diva-309674 (URN)
    Conference
    Nordic Accounting Conference (NORAC), 2016, 17-18 November, Copenhagen Business School, Denmark, The 10th Conference on New Directions in Management Accounting, 2016, 14-16 December, EIASM, Brussels, Belgium, European Network for Research in Organisational and Accounting Change (ENROAC), 2017, 29-30 June, University of Naples "Federico II", Italy.
    Available from: 2016-12-06 Created: 2016-12-06 Last updated: 2017-10-23
    2. Accounting and control in banks: A literature review
    Open this publication in new window or tab >>Accounting and control in banks: A literature review
    Show others...
    2017 (English)In: Bank Regulation: Effects on Strategy, Financial Accounting, and Management Control / [ed] Anna-Karin Stockenstrand, Fredrik Nilsson, New York: Routledge, 2017, 1, 15-63 p.Chapter in book (Other academic)
    Place, publisher, year, edition, pages
    New York: Routledge, 2017 Edition: 1
    Series
    Routledge Studies in Accounting, 19
    Keyword
    Accounting regulation, bank lending, corporate governance, fair value accounting, management control, stakeholders in banking, task control
    National Category
    Business Administration
    Research subject
    Business Studies
    Identifiers
    urn:nbn:se:uu:diva-312455 (URN)978-1-138-68050-0 (ISBN)978-1-315-56389-3 (ISBN)
    Note

    In press

    Available from: 2017-01-09 Created: 2017-01-09 Last updated: 2017-10-23
    3. A Prediction-Postdiction Model of Risk Regulation and Governance in Banking: Infusing a Perspective from Psychology Theory
    Open this publication in new window or tab >>A Prediction-Postdiction Model of Risk Regulation and Governance in Banking: Infusing a Perspective from Psychology Theory
    2017 (English)Conference paper, Oral presentation only (Refereed)
    Abstract [en]

    After the 2007–08 financial crisis, risk management failures in banks have drawn increasing regulatory attention, in turn promoting increasing risk-governance development. Regulatory efforts to refine policy temporarily leads to increased confidence by politicians and society in the risk management concept, but when a failure occurs, public intolerance increases dramatically, threating the legitimacy of financial institutions. The cyclical nature of this empirical phenomenon would seem to be closely related to how events are interpreted, not just by individuals but by society in general. Borrowing a term used in psychology, our understanding of this cyclical process may be improved by using what we might call the prediction-postdiction model of risk regulation and governance. The cycle has been the basis for considerable debate in public hearings, amongst regulatory bodies and in academic publications. Much of that debate has focused on the further development of formal policies, structures, and processes with very little attention given to the significance of individual actors or acknowledging the complexity and variation of practices in individual banks. In that void, multiple assumptions fill a space in order that politicians, the media, and even regulatory authorities, can reconcile predictive and post-hoc accounts. By drawing on psychological theory (cf. Hall 2016) and using empirical evidence from a case study of a large European bank, I propose that a better understanding of the crisis-regulation cycle can be achieved by applying the prediction-postdiction model. This may help us to see how some of the actions undertaken may be ineffective or even dysfunctional, as they build on assumptions which are dubious or wrong. The model can aid us in examining how the operation and effects of risk-management practices influence individual mental processes and behaviors over time. In doing so I offer deep empirical descriptions from a wide variety of individual perspectives on risk management's influence on behavior and how in aggregate this, in turn, influences organizational outcomes. Finally, I explain how these tentative findings can be used in future research.

    Keyword
    Accounting, Control, Regulation, Prediction, Postdiction, Risk
    National Category
    Business Administration
    Research subject
    Business Studies
    Identifiers
    urn:nbn:se:uu:diva-242123 (URN)
    Conference
    40th European Annual Congress (EAA)
    Available from: 2015-01-21 Created: 2015-01-21 Last updated: 2017-10-31
    4. Controlling Bank's IT in the Wake of Increasing Regulatory Demands: A Swedish Perspective
    Open this publication in new window or tab >>Controlling Bank's IT in the Wake of Increasing Regulatory Demands: A Swedish Perspective
    2017 (English)In: Bank Regulation: Effects on Strategy, Financial Accounting and Management Control, Routledge, 2017, 206-230 p.Chapter in book (Refereed)
    Place, publisher, year, edition, pages
    Routledge, 2017
    National Category
    Social Sciences
    Identifiers
    urn:nbn:se:uu:diva-312458 (URN)
    Available from: 2017-01-09 Created: 2017-01-09 Last updated: 2017-10-23
  • Kulkarni, Yashraj S.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Liao, Qinghua
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Petrovic, Dusan
    Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany..
    Krüger, Dennis M.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strodel, Birgit
    Forschungszentrum Julich, Inst Complex Syst Struct Biochem, D-52425 Julich, Germany.;Heinrich Heine Univ Dusseldorf, Inst Theoret & Computat Chem, Univ Str 1, D-40225 Dusseldorf, Germany..
    Amyes, Tina L.
    SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA..
    Richard, John P.
    SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA..
    Kamerlin, Shina C. L.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase2017In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 139, no 30, 10514-10525 p.Article in journal (Refereed)
    Abstract [en]

    Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde phosphate (GAP), via general base catalysis by E165. Historically, this enzyme has been an extremely important model system for understanding the fundamentals of biological catalysis. TIM is activated through an energetically demanding conformational change, which helps position the side chains of two key hydrophobic residues (1170 and L230), over the carboxylate side chain of E165. This is critical both for creating a hydrophobic pocket for the catalytic base and for maintaining correct active site architecture. Truncation of these residues to alanine causes significant falloffs in TIM's catalytic activity, but experiments have failed to provide a full description of the action of this clamp in promoting substrate deprotonation. We perform here detailed empirical valence bond calculations of the TIM-catalyzed deprotonation of DHAP and GAP by both wild type TIM and its 1170A, L230A, and 1170A/L230A mutants, obtaining exceptional quantitative agreement with experiment. Our calculations provide a linear free energy relationship, with slope 0.8, between the activation barriers and Gibbs free energies for these TIM-catalyzed reactions. We conclude that these clamping side chains minimize the Gibbs free energy for substrate deprotonation, and that the effects on reaction driving force are largely expressed at the transition state for proton transfer. Our combined analysis of previous experimental and current computational results allows us to provide an overview of the breakdown of ground-state and transition state effects in enzyme catalysis in unprecedented detail, providing a molecular description of the operation of a hydrophobic clamp in triosephosphate isomerase.

  • Karlsson, Anna
    et al.
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden..
    Brunnström, Hans
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden.;Reg Labs Reg Skane, Dept Pathol, Lund, Sweden..
    Micke, Patrick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Veerla, Srinivas
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden..
    Mattsson, Johanna Sofia Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    La Fleur, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Botling, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Jönsson, Mats
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden..
    Reuterswärd, Christel
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden..
    Planck, Maria
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden.;Skane Univ Hosp, Dept Resp Med & Allergol, Lund, Sweden..
    Staaf, Johan
    Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, SE-22381 Lund, Sweden..
    Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification2017In: Journal of Thoracic Oncology, ISSN 1556-0864, E-ISSN 1556-1380, Vol. 12, no 8, 1257-1267 p.Article in journal (Refereed)
    Abstract [en]

    Introduction: Large cell lung cancer (LCLC) and large cell neuroendocrine carcinoma (LCNEC) constitute a small proportion of NSCLC. The WHO 2015 classification guidelines changed the definition of the debated histological subtype LCLC to be based on immunomarkers for adenocarcinoma and squamous cancer. We sought to determine whether these new guidelines also translate into the transcriptional landscape of lung cancer, and LCLC specifically.

    Methods: Gene expression profiling was performed by using Illumina V4 HT12 microarrays (Illumina, San Diego, CA) on samples from 159 cases (comprising all histological subtypes, including 10 classified as LCLC WHO 2015 and 14 classified as LCNEC according to the WHO 2015 guidelines), with complimentary mutational and immunohistochemical data. Derived transcriptional phenotypes were validated in 199 independent tumors, including six WHO 2015 LCLCs and five LCNECs.

    Results: Unsupervised analysis of gene expression data identified a phenotype comprising 90% of WHO 2015 LCLC tumors, with characteristics of poorly differentiated proliferatiVe cancer, a 90% tumor protein p53 gene (TP53) mutation rate, and lack of well-known NSCLC oncogene driver alterations. Validation in independent data confirmed aggregation of WHO 2015 LCLCs in the specific phenotype. For LCNEC tumors, the unsupervised gene expression analysis suggested two different transcriptional patterns corresponding to a proposed genetic division of LCNEC tumors into SCLC-like and NSCLC-like cancer on the basis of TP53 and retinoblastoma 1 gene (RB1) alteration patterns.

    Conclusions: Refined classification of LCLC has implications for diagnosis, prognostics, and therapy decisions. Our molecular analyses support the WHO 2015 classification of LCLC and LCNEC tumors, which herein follow different tumorigenic paths and can accordingly be stratified into different transcriptional subgroups, thus linking diagnostic immunohistochemical staining driven classification with the transcriptional landscape of lung cancer.

  • Högerås, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Batterimatning som reservdrift på mellanspänningsnätet2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The grid in the northern part of Sweden is characterized by long radial lines with just a few customers. To secure electricity supply it is necessary to have a redundant feeding alternative. A loop structured grid which is used in the more populated urban area is a poor solution in the rural areas both regarding economy and technology due to the long distances. To feed the northern grid in Sweden a battery energy storage system (BESS) is therefore a solution that could secure the power delivery. An important aspect to investigate is how the electric power quality changes with the new feeder, but more importantly to secure disconnection of supply at fault occurrence.

     

    This thesis investigates how a battery storage system installed at the end of a mid-voltage line affects the electric power quality and the protection system compared to a reference case which represents the line today. The mid-voltage line is an existing line in the northern grid and is a good representation of the general northern grid.  

     

    The results obtained from this study show that the loop impedance does not necessarily have to deteriorate with the new feeder, which means that the voltage quality in this aspect does not change. This is only true for this particular grid when the impedance contribution from the mid-voltage grid is small and the contribution from the low-voltage grid is large because of long and weak distribution low-voltage lines.  

     

    The inverter is the limiting factor for the short circuit currents, and the short circuit power and current decrease with the new feeder. At fault occurrence in the low voltage grid the short circuit current does not affect the fuse blow. However the inverter will disconnect for all fault occurrences in the mid-voltage grid, and for faults with high short circuit power in the low voltage grid. This means that the selectivity will decrease, but the system will have a high security level.

     

    For this particular grid the results show that the transformer can be isolated from the ground. A residual overvoltage relay is enough for disconnection of grounding faults. Directional ground fault protection is not necessary for this line with this particular characteristics. If the sensitivity for the disconnection of grounding faults with high transition impedances is adjusted according to ground fault currents in island operation, the sensitivity then decreases at the event of a fault during normal operations when the battery storage system is charging. The sensitivity might also be tuned according to normal operation, which then results in a higher sensitivity than necessary during island operation.    

  • Avraam, Elsa
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of ALM.
    Knowledge Organisation and Contemporary Art: Cataloguing Practices in two Libraries in Sweden, Umeå universitetsbibliotek and Konstbiblioteket2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This master thesis examines the cataloguing practices of two art libraries in Sweden in relation to contemporary art. The aim of this study is to show how classification systems and other forms of controlled vocabulary correspond to contemporary art and reveal the factors that influence the everyday practice of cataloguing.

    The qualitative methods of semi-structured interviews and an analysis of bibliographic records have been used for the purposes of this study. The study is based on domain analysis as conceived by Hjørland and Albrechtsen and some concepts and principles of Knowledge Organisation in the field of Library and Information Science.

    A total of three interviews of cataloguers has proved that perceptions concerning classification and subject indexing differ among cataloguers and cataloguing practices depend on local policies concerning acquisition, shelving and user perspectives, but also each library’s resources and the institutional context (academic vs museum). Through the analysis of eleven bibliographic records, no consistent pattern has been detected, in relation to indexing and classification. The libraries do not use special systems for subject analysis. The classifications provided by universal systems have been considered insufficient to express all the concepts found in documents. The use of subject headings is, therefore, important and complements the process of subject analysis. The classification systems and subject headings lists analysed include the Dewey Decimal Classification (DDC), the Swedish Sveriges Allmänna Biblioteksförenings Klassifikationssystem (SAB) and the Svenska ämnesord (SAO). This is a two-year master’s thesis in Archive, Library and Museum studies.

  • Kawakami, Takeshi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Univ Sheffield, Dept Anim & Plant Sci, Sheffield, S Yorkshire, England..
    Mugal, Carina
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Suh, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Nater, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Univ Zurich, Dept Evolutionary Biol & Environm Studies, Zurich, Switzerland..
    Burri, Reto
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Friedrich Schiller Univ Jena, Dept Populat Ecol, Jena, Germany..
    Smeds, Linnea
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Ellegren, Hans
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds2017In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 26, no 16, 4158-4172 p.Article in journal (Refereed)
    Abstract [en]

    Recombination rate is heterogeneous across the genome of various species and so are genetic diversity and differentiation as a consequence of linked selection. However, we still lack a clear picture of the underlying mechanisms for regulating recombination. Here we estimated fine-scale population recombination rate based on the patterns of linkage disequilibrium across the genomes of multiple populations of two closely related flycatcher species (Ficedula albicollis and F. hypoleuca). This revealed an overall conservation of the recombination landscape between these species at the scale of 200 kb, but we also identified differences in the local rate of recombination despite their recent divergence (<1 million years). Genetic diversity and differentiation were associated with recombination rate in a lineage-specific manner, indicating differences in the extent of linked selection between species. We detected 400-3,085 recombination hotspots per population. Location of hotspots was conserved between species, but the intensity of hotspot activity varied between species. Recombination hotspots were primarily associated with CpG islands (CGIs), regardless of whether CGIs were at promoter regions or away from genes. Recombination hotspots were also associated with specific transposable elements (TEs), but this association appears indirect due to shared preferences of the transposition machinery and the recombination machinery for accessible open chromatin regions. Our results suggest that CGIs are a major determinant of the localization of recombination hotspots, and we propose that both the distribution of TEs and fine-scale variation in recombination rate may be associated with the evolution of the epigenetic landscape.

  • Ardesjö-Lundgren, Brita
    et al.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Box 7023, SE-75007 Uppsala, Sweden..
    Tengvall, Katarina
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Karolinska Inst, Neuroimmunol Unit, Centrum Mol Med, Dept Clin Neurosci, S-17176 Stockholm, Sweden..
    Bergvall, Kerstin
    Swedish Univ Agr Sci, Dept Clin Sci, Box 7054, SE-75007 Uppsala, Sweden..
    Farias, Fabiana H. G.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Wang, Liya
    Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Box 7011, S-75007 Uppsala, Sweden..
    Hedhammar, Åke
    Swedish Univ Agr Sci, Dept Clin Sci, Box 7054, SE-75007 Uppsala, Sweden..
    Lindblad-Toh, Kerstin
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Broad Inst MIT & Harvard, 415 Main St, Cambridge, MA 02142 USA..
    Andersson, Göran
    Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Box 7023, SE-75007 Uppsala, Sweden..
    Comparison of cellular location and expression of Plakophilin-2 in epidermal cells from nonlesional atopic skin and healthy skin in German shepherd dogs2017In: Veterinary dermatology (Print), ISSN 0959-4493, E-ISSN 1365-3164, Vol. 28, no 4, 377-e88 p.Article in journal (Refereed)
    Abstract [en]

    Background - Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease caused by interactions between genetic and environmental factors. Previously, a genome-wide significant risk locus on canine chromosome 27 for CAD was identified in German shepherd dogs (GSDs) and Plakophilin-2 (PKP2) was defined as the top candidate gene. PKP2 constitutes a crucial component of desmosomes and also is important in signalling, metabolic and transcriptional activities.

    Objectives - The main objective was to evaluate the role of PKP2 in CAD by investigating PKP2 expression and desmosome structure in nonlesional skin from CAD-affected (carrying the top GWAS SNP risk allele) and healthy GSDs. We also aimed at defining the cell types in the skin that express PKP2 and its intracellular location.

    Animals/Methods - Skin biopsies were collected from nine CAD-affected and five control GSDs. The biopsies were frozen for immunofluorescence and fixed for electron microscopy immunolabelling and morphology.

    Results - We observed the novel finding of PKP2 expression in dendritic cells and T cells in dog skin. Moreover, we detected that PKP2 was more evenly expressed within keratinocytes compared to its desmosomal binding partner plakoglobin. PKP2 protein was located in the nucleus and on keratin filaments attached to desmosomes. No difference in PKP2 abundance between CAD cases and controls was observed.

    Conclusion - Plakophilin-2 protein in dog skin is expressed in both epithelial and immune cells; based on Its sub cellular location its functional role is implicated in both nuclear and structural processes.

  • Sepahvand, Mohammad H
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Shahbazian, Roujman
    Swedish Institute for Social Research, Stockholm University.
    Intergenerational Transmission of Risk Attitudes:The Role of Gender, Parents and Grandparents in Burkina Faso2017Report (Other academic)
    Abstract [en]

    This study investigates the intergenerational transmission of risk attitudes for three risk domains in Burkina Faso. First, our results shows a strong transmission of attitudes from parents to children. Although, estimates from intergenerational transmission of risk attitudes in developing countries should not be compared directly with those from developed countries, our results goes in the same direction as previous literature from Germany. That is risk attitudes are transmitted from; parents to children, local enviorment to children and positive assortative mating of parents strengthens the parents’ transmission of attitudes to her child. Second we analyze three generations of risk attitude transmission. Our results indicates that it exist a transmission of risk attitudes from grandparents to their grandchildren. The strength and significance of this socialization decreases when we control for parents risk attitudes. Third, since there are strong gender roles in Burkina Faso, we test if mothers and fathers transmission of risk attitudes on their daughter is the same as on their son. We find that mother’s transmission of risk attitudes is stronger on their daughters than sons. For fathers the pattern is reverse. However, our findings show that it exist a heterogenity in the transmission of risk attitudes in male and female dominated risk domains. This gives support for the gender-specific role model hypothesis in terms of risk attitudes.

  • Buzzi, Michele
    et al.
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Makita, Mikako
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Howald, Ludovic
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Kleibert, Armin
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Vodungbo, Boris
    Ecole Polytech, CNRS, UMR 7639, Lab Opt Appl,ENSTA ParisTech, Chemin Huniere, F-91761 Palaiseau, France.;UPMC Univ Paris 06, Sorbonne Univ, CNRS, LCPMR, F-75005 Paris, France..
    Maldonado, Pablo
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Raabe, Jörg
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Jaouen, Nicolas
    Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Redlin, Harald
    DESY, HASYLAB, Notkestr 85, D-22607 Hamburg, Germany..
    Tiedtke, Kai
    DESY, HASYLAB, Notkestr 85, D-22607 Hamburg, Germany..
    Oppeneer, Peter M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    David, Christian
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Nolting, Frithjof
    Paul Scherrer Inst, CH-5232 Villigen, Switzerland..
    Luning, Jan
    UPMC Univ Paris 06, Sorbonne Univ, CNRS, LCPMR, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Single-shot Monitoring of Ultrafast Processes via X-ray Streaking at a Free Electron Laser2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 7253Article in journal (Refereed)
    Abstract [en]

    The advent of x-ray free electron lasers has extended the unique capabilities of resonant x-ray spectroscopy techniques to ultrafast time scales. Here, we report on a novel experimental method that allows retrieving with a single x-ray pulse the time evolution of an ultrafast process, not only at a few discrete time delays, but continuously over an extended time window. We used a single x-ray pulse to resolve the laser-induced ultrafast demagnetisation dynamics in a thin cobalt film over a time window of about 1.6 ps with an excellent signal to noise ratio. From one representative single shot measurement we extract a spin relaxation time of (130 +/- 30) fs with an average value, based on 193 single shot events of (113 +/- 20) fs. These results are limited by the achieved experimental time resolution of 120 fs, and both values are in excellent agreement with previous results and theoretical modelling. More generally, this new experimental approach to ultrafast x-ray spectroscopy paves the way to the study of non-repetitive processes that cannot be investigated using traditional repetitive pump-probe schemes.

  • Bergström, Joakim J. E.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Heyman, Birgitta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG2017In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, 911Article in journal (Refereed)
    Abstract [en]

    Antigen-specific IgG antibodies, passively administered together with large particulate antigens such as erythrocytes, can completely suppress the antigen-specific antibody response. The mechanism behind has been elusive. Herein, we made the surprising observation that mice immunized with IgG anti-sheep red blood cells (SRBC) and SRBC, in spite of a severely suppressed anti-SRBC response, have a strong germinal center (GC) response. This occurred regardless of whether the passively administered IgG was of the same allotype as that of the recipient or not. Six days after immunization, the GC size and the number of GC B cells were higher in mice immunized with SRBC alone than in mice immunized with IgG and SRBC, but at the other time points these parameters were similar. GCs in the IgG-groups had a slight shift toward dark zone B cells 6 days after immunization and toward light zone B cells 10 days after immunization. The proportions of T follicular helper cells (TFH) and T follicular regulatory cells (TFR) were similar in the two groups. Interestingly, mice immunized with allogeneic IgG anti-SRBC together with SRBC mounted a vigorous antibody response against the passively administered suppressive IgG. Thus, although their anti-SRBC response was almost completely suppressed, an antibody response against allogeneic, and probably also syngeneic, IgG developed. This most likely explains the development of GCs in the absence of an anti-SRBC antibody response.

  • Bergman, Ann-Sofie
    et al.
    Inst. för socialt arbete, Linnéuniversitetet.
    Rejmer, Annika
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Parents in child custody disputes: Why are they disputing?2017In: Journal of Child Custody, ISSN 1537-9418, 1-17 p.Article in journal (Refereed)
    Abstract [en]

    Although society has put significant effort in order to help parents to resolve disputes regarding custody, residence and contact, the research related to this field of studies is relatively unexplored. There exists e.g. an absence of a differentiated view of the parents and their conflict. This fact can explain why there are a very limited number of methods for conflict resolution. In Sweden e.g. the only methods offered by society are cooperative talks and adjudication in the courts. Every year, parents take 7,000 children to the custody cases to be resolved in the courts. However, the conflicts often remain unresolved and which increases the risk of disorders in children. The overall aim of this project is to scientifically investigate what characterizes parents in high conflict divorce and their conflicts and to explore the short and long term effects of three different models for conflict resolution. The proposed project consist of two sub studies, of which one is a survey of parents and their conflict and the other is an investigation of the impact of the models. The results of the project are expected to show strength and weaknesses of the models when applied on different groups of parents and types of conflicts. The project is of international and national importance and a prerequisite for a further development of the handling of custody disputes. The results can also contribute to a further theoretical and methodological development of the research field.

  • Ahlberg, Kerstin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Visual literacy i klassrummet: En studie av elevers visuella praktiker i bild, svenska och NO2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna studie är att utifrån elevernas perspektiv undersöka vilken visual literacy som förväntas i ämnena bild, svenska och NO i grundskolans årskurs 4-6. Frågeställningarna fokuserar vilka visuella praktiker eleverna deltar i och vilken literacy som kommer till uttryck i dessa praktiker, hur eleverna förhåller sig och vilket stöd de erbjuds när de hanterar visuellt material.

    Teoretiskt utgår studien från områdena Visuell kultur och New literacy studies, men den vilar också på socialsemiotisk forskning och teorier om multimodalitet. Inom New literacy studies undersöks textpraktiker, i detta arbete är det elevernas visuella praktiker som studeras, dvs. när eleverna läser och skapar bilder i undervisningen.

    Metodologiskt bygger studien på visuell etnografi, där forskningsmaterialet producerats genom deltagande observation i fyra klasser på mellanstadiet. Fotografier, observationsanteckningar och utskrifter av intervjuer med fyra elevgrupper utgör underlaget för analysen.

    Analysen visar att eleverna deltar i flera olika visuella praktiker inom ramen för de studerade ämnena. Det handlar om att skapa bilder eller digitala presentationer, men också om att läsa texter med visuellt material eller att se streamade filmer. Dessa praktiker uppvisar både likheter och skillnader. Sammanfattningsvis får eleverna möjligheter att lära om material och tekniker, använda och kommunicera med bilder, men undervisas i mindre mån i att analysera visuella uttryck. Undersökningen görs mot bakgrund av det ökade bildflödet i samhället. Om eleverna ska bli visuellt litterata krävs att alla ämnen tar ansvar för att behandla de visuella material som används i undervisningen. För bildämnets del betyder det också att lärarna måste ta den kommunikativa inriktningen på allvar och öva eleverna inte bara i att skapa bilder, utan också i att analysera och kritiskt granska de bilduttryck de möter.  

  • Ögren, Jim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    ELEPHANT: A MATLAB-code for Hamiltonians, Lie algebra, normal form and particle tracking2017Report (Other academic)
    Abstract [en]

    In this report we explain the structure and functionality of ELEPHANT: a MATLAB-code developed for particle tracking and treating Hamiltonians in the Lie formalism with applications for accelerator physics. The code can operate on Hamiltonians and using the similarity transform and the Campbell-Baker-Hausdorff formula to express a map as an effective Hamiltonian and a linear map.The code can also express a map in a normal form and from this calculate the amplitude-dependenttune-shifts. Finally, the code can analyze the standard linear transverse dynamics and do particletracking. The purpose of the code is to treat nonlinear fields analytically and cross-check with tracking results.

  • Herdenberg, Nils David
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    IDPs, Durable Solutions and Citizenship: Perspectives from Ukraine2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study explores how Donbass IDPs in Kyiv view the role of the state in relation to ‘durable solutions’ to their displacement. Specifically, it examines the expectations on the state as a provider of rights and entitlements vis-à- vis IDPs. Drawing on semi-structured interviews with Donbas IDPs, experiences of displacement and perceptions of durable solutions and citizen-state relations are exemplified. The data collection and analysis methodologies applied allow for the elicitation of the views and opinions of IDPs, in an attempt to mitigate vertical policy-making. The concepts of citizenship, state and sovereignty are applied to analyze the relationship between IDPs and the state. Further, the IASC framework for durable solutions to internal displacement is used to as a structure to outline the views of the IDPs. The results show a large discrepancy between the expectations of the respondents on the states’ role in durable solutions to displacement, and the experience of this in reality. Furthermore, the results reveal high levels of discontent, resignation and apathy towards the state as a provider of durable solutions, especially in terms of returning to Donbass. 

  • Public defence: 2017-12-11 13:00 Häggsalen, Ångströmlaboratoriet, Uppsala
    Johari, Dalina
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Features of the Electric Fields Generated by Lightning with Special Attention to Positive Ground Flashes2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis focuses on the main processes in positive ground flashes and the distant lightning environment for both positive and negative ground flashes. It presents the characteristics of the preliminary breakdown pulses (PBPs), the characteristics of the electric field pulses observed during leader propagation, and the characteristics of the electric fields produced by the first and the subsequent return strokes. It also features the observations of distant positive and negative ground flashes at distances up to 1000 km. The results were based on electric field measurements conducted remotely during summer thunderstorms in Sweden in 2014.

    We found that the majority of the positive ground flashes were preceded by PBPs. Some were preceded by more than one PBP train, and the parameter values for the subsequent PBP trains were found to be smaller than the values for the first PBP train. Three types of PBPs were also identified. The results suggest that the PBPs in positive ground flashes during summer thunderstorms in Sweden are weak, and the inverted dipole charge cloud configuration is consistent with our observation.

    A small percentage of these positive ground flashes were observed to be preceded by pronounced leader pulses. The presence of these pulses suggests that the leaders propagate in a stepped manner. We inferred that these pulses were due to the upward-connecting negative leader since their characteristics were similar to those of a negative stepped leader. On the basis of the leader pulses’ time of initiation and the average speed of the leader, we estimated the distance travelled by the leader. One case of positive return stroke preceded by negative leader pulses was also observed, and the occurrence of these pulses was the first in positive ground flashes to be reported.

    The majority of these positive ground flashes were found to be single-stroke. Comparison between the first and the subsequent return strokes showed that the average durations of the subsequent stroke parameters were smaller than that of the first strokes. The distances reported by the lightning location system suggest that the subsequent strokes probably created new terminations to ground. Two possible reasons were given to explain the reason for the shorter duration of the subsequent return strokes parameters compared to the first strokes.

    Finally, observations of distant positive and negative ground flashes showed that the electric field waveforms have a typical shape, like a distorted ‘W’ (or distorted ‘M’ for negative ground flashes) followed by small oscillations. These small oscillations were more pronounced in negative ground flashes, especially at a greater distance. The heights of the ionospheric reflections estimated for both ground flashes were found to likely correspond to a D-layer of the ionosphere. Two possible reasons were suggested for the small oscillations observed in the waveforms.

    List of papers
    1. Characteristics of preliminary breakdown pulses in positive ground flashes during summer thunderstorms in Sweden
    Open this publication in new window or tab >>Characteristics of preliminary breakdown pulses in positive ground flashes during summer thunderstorms in Sweden
    Show others...
    2016 (English)In: Atmosphere, ISSN 2073-4433, E-ISSN 2073-4433, Vol. 7, no 3, 39Article in journal (Refereed) Published
    Abstract [en]

    This paper presents the characteristics of the preliminary breakdown pulses (PBP) in 51 positive ground flashes recorded during 2014 summer thunderstorms in Sweden. Electric field measurements were conducted remotely using a broadband antenna system (up to 100 MHz) for a recording length of 1 s with 200 ms trigger time. In the analysis, PBP trains were observed in 86% of the cases. Based on the number of trains preceding the first return stroke, the PBP were classified into single and multiple train PBP. Characteristics of the first PBP train were determined and based on the initial polarity of the pulses, three types of PBP were identified. Characteristics of the subsequent PBP trains in the multiple train PBP were also analyzed and they were compared with the first PBP train. Based on the conceptual charge cloud configuration, we found that the inverted dipole is consistent with our observation. We also found that PBP in positive ground flashes during summer thunderstorms in Sweden are weak since the average ratios of the PBP peak to the first return stroke peak lie only between 0.21 and 0.26. Possible reasons for no detection of PBP and the different types of PBP observed were also discussed.

    National Category
    Meteorology and Atmospheric Sciences Engineering and Technology
    Research subject
    Engineering Science with specialization in Atmospheric Discharges
    Identifiers
    urn:nbn:se:uu:diva-280866 (URN)10.3390/atmos7030039 (DOI)000373529700002 ()
    Available from: 2016-03-15 Created: 2016-03-15 Last updated: 2017-10-20Bibliographically approved
    2. Characteristics of leader pulses in positive ground flashes in Sweden
    Open this publication in new window or tab >>Characteristics of leader pulses in positive ground flashes in Sweden
    Show others...
    2017 (English)In: Electric power systems research, ISSN 0378-7796, E-ISSN 1873-2046, Vol. 153, 3-9 p.Article in journal (Refereed) Published
    National Category
    Meteorology and Atmospheric Sciences Engineering and Technology
    Research subject
    Engineering Science with specialization in Atmospheric Discharges
    Identifiers
    urn:nbn:se:uu:diva-293059 (URN)
    Available from: 2016-05-11 Created: 2016-05-11 Last updated: 2017-10-20
    3. Features of the First and Subsequent Return Strokes in Positive Ground Flashes based on Electric Field Measurements
    Open this publication in new window or tab >>Features of the First and Subsequent Return Strokes in Positive Ground Flashes based on Electric Field Measurements
    Show others...
    2017 (English)In: Electric power systems research, ISSN 0378-7796, E-ISSN 1873-2046, Vol. 150, 55-62 p.Article in journal (Refereed) Published
    Abstract [en]

    This paper presents the characteristics of the electric fields produced by the first and the subsequent return strokes observed in positive ground flashes in Sweden. Fifty one positive ground flashes containing 60 return strokes recorded during 2014 summer thunderstorms were analyzed. In our analysis, only 12% of the cases were multiple-stroke while 88% were single-stroke. On average, the number of strokes per flash was 1.20 and the highest number of strokes per flash recorded was four. The geometric mean (GM) value of the interstroke interval was 60 ms while the distance between the first and the subsequent strokes ranged between 4.9 and 46.4km. We found that the average duration of the subsequent strokes parameters were smaller than that of the first strokes. For the first strokes, the GM values of the slow front duration, the fast transition 10-to-90% risetime, the zero crossing time, the zero-to-peak risetime and the 10-to-90% risetime were 8.7 mu s, 1.4 mu s, 29 mu s, 11 mu s and 5.7 mu s, respectively while for the subsequent strokes, the values were 4.0 mu s 0.91 mu s, 11 mu s 5.8 mu s and 3.2 mu s, respectively. Possible reasons for the shorter duration of the subsequent return strokes parameters were discussed.

    National Category
    Meteorology and Atmospheric Sciences Engineering and Technology
    Research subject
    Engineering Science with specialization in Atmospheric Discharges
    Identifiers
    urn:nbn:se:uu:diva-317450 (URN)10.1016/j.epsr.2017.04.031 (DOI)000403744100006 ()
    Available from: 2017-03-14 Created: 2017-03-14 Last updated: 2017-10-20Bibliographically approved
    4. Oscillations Observed in Bipolar Electric Fields from Distant Cloud-to-Ground Lightning Flashes
    Open this publication in new window or tab >>Oscillations Observed in Bipolar Electric Fields from Distant Cloud-to-Ground Lightning Flashes
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    This paper presents the observations of distant positive and negative ground flashes at distances up to 1000 km recorded during 2014 summer thunderstorms in Sweden. We observed that the electric field waveforms have a typical shape, like a distorted 'W' (or a distorted ‘M’ for negative ground flashes) followed by small oscillations. Compared to positive ground flashes, the small oscillations were more pronounced in negative ground flashes. All of the positive ground flashes were single-stroke while 74% of the negative ground flashes had subsequent return strokes (SRS). The SRS in negative ground flashes showed wave shapes similar to those of the first return strokes. For both the positive and negative ground flashes, preliminary breakdown pulse (PBP) trains were observed in 71% of the cases. The average time separation between the largest PBP and the ground wave were much larger for positive ground flashes compared to that of the negative ground flashes. Based on the difference in time intervals between the ground wave and the first sky wave, the ionospheric reflections heights were estimated to be 71 and 67 km for positive and negative ground flashes, respectively, corresponding probably to a D-layer of the ionosphere. We have also determined the amplitudes of the small oscillations relative to the return stroke peak, the period of the oscillations and their corresponding frequencies. We suggest that the small oscillations observed in the waveforms either come from the low frequency component of the return stroke current that oscillates in the lightning channel or due to the filtering of the frequencies by the propagation through the Earth-ionosphere waveguide.

    National Category
    Meteorology and Atmospheric Sciences Engineering and Technology
    Research subject
    Engineering Science with specialization in Atmospheric Discharges
    Identifiers
    urn:nbn:se:uu:diva-331837 (URN)
    Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-10-20
  • Persson, Philip
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Fredin, Emil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Basel III: En studie om hur banker och dess kunder påverkas avdet nya regelverket2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    To prevent the emergence of bank crises and to help banks resist turbulent economy,

    the Basel Committee created a regulation framework. This framework was introduced

    in 1993 and was called Basel-1. During the years this framework has been

    changed to suite new situations. The latest change was done after the financial crises

    in 2008 and is going to be implemented in 2013. This, latest edition is called Basel-3

    and includes among other things a strong capital requirement. Before the implementation

    of Basel-3 many questions has come to light. To answer some of these, two

    problem formulations have been created in this thesis.

    How do the bank office managers think that they will be affected by the new regulations

    of Basel-3?

    How do the bank office managers think that their customers will be affected by the

    new regulations of Basel-3?

    To seek the answers to these questions, three bank directors have answered quite

    many questions in interviews and by e-mail. These answers have been formed and

    put together to get an idea of what they think will happen when the new regulations

    of Basel-3 will be implemented.

    When analyzing these answers the authors have found out that both the banks and

    their customers probably and already have been affected by these new regulations in

    quite many ways.

  • Public defence: 2017-12-12 09:30 Polhemssalen, Uppsala
    Lindgren, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Metallicity determination of M dwarfs2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    M dwarfs constitute around 70% of all stars in the local Galaxy. Their multitude together with their long main-sequence lifetimes make them important for studies of global properties of the Galaxy such as the initial mass function or the structure and kinematics of stellar populations. In addition, the exoplanet community is showing an increasing interest for those small, cold stars. However, very few M dwarfs are well characterized, and in the case of exoplanetary systems the stellar parameters have a direct influence on the derived planet properties.

    Stellar parameters of M dwarfs are difficult to determine because of their low surface temperatures that result in an optical spectrum dominated by molecular lines. Most previous works have therefore relied on empirical calibrations. High-resolution spectrographs operating in the infrared, a wavelength region less affected by molecular lines, have recently opened up a new window for the investigation of M dwarfs. In the two first papers of this thesis we have shown that we can determine the metallicity, and in some cases the effective temperature, using synthetic spectral fitting with improved accuracy.

    This method is time consuming and therefore not practical or even feasible for studies of large samples of M dwarfs. When comparing our results from the high-resolution studies with available photometric calibrations we find systematic differences. In the third paper we therefore used our sample to determine a new photometric metallicity calibration. Compared to previous calibrations our new photometric calibration shows improved statistical characteristics, and our calibration gives similar results as spectroscopic calibrations. In a comparison with theoretical calculations we find a good agreement of the shapes and slopes of iso-metallicity lines with our empirical relation. Applying the photometric calibration to a sample of M dwarfs with confirmed exoplanets we find a possible giant planet-metallicity correlation for M dwarfs.

    List of papers
    1. Metallicity determination of M dwarfs: High-resolution infrared spectroscopy
    Open this publication in new window or tab >>Metallicity determination of M dwarfs: High-resolution infrared spectroscopy
    2016 (English)In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 586, A100Article in journal (Refereed) Published
    Abstract [en]

    Context. Several new techniques to determine the metallicity of M dwarfs with better precision have been developed over the last decades. However, most of these studies were based on empirical methods. In order to enable detailed abundance analysis, standard methods established for warmer solar-like stars, i.e. model-dependent methods using fitting of synthetic spectra, still need to be used.

    Aims. In this work we continue the reliability confirmation and development of metallicity determinations of M dwarfs using high-resolution infrared spectra. The reliability was confirmed through analysis of M dwarfs in four binary systems with FGK dwarf companions and by comparison with previous optical studies of the FGK dwarfs.

    Methods. The metallicity determination was based on spectra taken in the J band (1.1-1.4 mu m) with the CRIRES spectrograph. In this part of the infrared, the density of stellar molecular lines is limited, reducing the amount of blends with atomic lines enabling an accurate continuum placement. Lines of several atomic species were used to determine the stellar metallicity.

    Results. All binaries show excellent agreement between the derived metallicity of the M dwarf and its binary companion. Our results are also in good agreement with values found in the literature. Furthermore, we propose an alternative way to determine the effective temperature of M dwarfs of spectral types later than M2 through synthetic spectral fitting of the FeH lines in our observed spectra.

    Conclusions. We have confirmed that a reliable metallicity determination of M dwarfs can be achieved using high-resolution infrared spectroscopy. We also note that metallicites obtained with photometric metallicity calibrations available for M dwarfs only partly agree with the results we obtain from high-resolution spectroscopy.

    Keyword
    stars: abundances, stars: low-mass, techniques: spectroscopic
    National Category
    Astronomy, Astrophysics and Cosmology
    Identifiers
    urn:nbn:se:uu:diva-281831 (URN)10.1051/0004-6361/201526602 (DOI)000369715900111 ()
    Funder
    Swedish National Space Board
    Available from: 2016-03-30 Created: 2016-03-30 Last updated: 2017-10-24
    2. Metallicity determination of M dwarfs: Expanded parameter range in metallicity and effective temperature
    Open this publication in new window or tab >>Metallicity determination of M dwarfs: Expanded parameter range in metallicity and effective temperature
    2017 (English)In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 604, A97Article in journal (Refereed) Published
    Abstract [en]

    Context. Reliable metallicity values for late K and M dwarfs are important for studies of the chemical evolution of the Galaxy and advancement of planet formation theory in low-mass environments. Historically it has been challenging to determine the stellar parameters of low-mass stars because of their low surface temperature, which causes several molecules to form in the photospheric layers. In our work we use the fact that infrared high-resolution spectrographs have opened up a new window for investigating M dwarfs. This enables us to use similar methods as for warmer solar-like stars.

    Aims. Metallicity determination with high-resolution spectra is more accurate than with low-resolution spectra, but it is rather time consuming. In this paper we expand our sample analyzed with this precise method both in metallicity and effective temperature to build a calibration sample for a future revised empirical calibration. Methods. Because of the relatively few molecular lines in the J band, continuum rectification is possible for high-resolution spectra, allowing the stellar parameters to be determined with greater accuracy than with optical spectra. We obtained high-resolution spectra with the CRIRES spectrograph at the Very Large Telescope (VLT). The metallicity was determined using synthetic spectral fitting of several atomic species. For M dwarfs that are cooler than 3575 K, the line strengths of FeH lines were used to determine the effective temperatures, while for warmer stars a photometric calibration was used.

    Results. We analyzed 16 targets with a range of effective temperature from 3350-4550 K. The resulting metallicities lie between -0.5 < [M/H] < +0.4. A few targets have previously been analyzed using low-resolution spectra and we find a rather good agreement with our values. A comparison with available photometric calibrations shows varying agreement and the spread within all empirical calibrations is large.

    Conclusions. Including the targets from our previous paper, we analyzed 28 M dwarfs with high-resolution infrared spectra. The targets spread approximately one dex in metallicity and 1400 K in effective temperature. For individual M dwarfs we achieve uncer- tainties of 0.05 dex and 100 K on average. 

    Keyword
    stars:low-mass–stars:abundances–techniques:spectroscopic
    National Category
    Astronomy, Astrophysics and Cosmology
    Research subject
    Astronomy
    Identifiers
    urn:nbn:se:uu:diva-332015 (URN)10.1051/0004-6361/201730715 (DOI)000408480100099 ()
    Funder
    Swedish National Space Board
    Available from: 2017-10-22 Created: 2017-10-22 Last updated: 2017-10-24Bibliographically approved
    3. A photometric calibration for M dwarfs based on high-resolution infrared spectrscopy
    Open this publication in new window or tab >>A photometric calibration for M dwarfs based on high-resolution infrared spectrscopy
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Context. M dwarfs are, by number, the dominant stellar population in the local Galaxy. We have previously shown that the stellar parameters of individual M dwarfs can be determined with good accuracy using high-resolution infrared spectroscopy. Since this method is time-consuming the use of empirical calibrations based on photometry or low-resolution spectra is preferable for studies of large samples. In earlier work we showed that available photometric calibrations for M dwarfs have offsets compared to our high- resolution metallicity results.

    Aims. We use a sample of 33 late K and M dwarfs with accurately determined metallicities to derive a new photometric calibration for M dwarfs. The aim is to achieve a calibration with lower uncertainty and better agreement with spectroscopic results.Methods. We explored the B, V, J, H, K, g, r, i magnitudes to find combinations that show a correlation between the metallicity and the position in a color-magnitude diagram. We used 5-fold cross-validation and the corrected Akaike information criterion to find a polynomial model that minimizes the information lost, exploring different polynomial degrees, with and without cross-terms. The coefficients were determined through a weighted least-squares solution against our calibration sample.

    Results. We present a new photometric metallicity calibration for M dwarfs, where the metallicity is given by a linear relation and onecross-termoftheMKSmagnitudeandtheV−(JHK) or B−(JHK) colors. The new calibration relations have root-mean-square deviation values with respect to the calibration sample of 0.11-0.12 dex, which is about 0.1 dex lower than for previous photometric calibrations, and we also achieve a substantial improvement of the value of the adjusted squared multiple correlation coefficient. We furthermore show that our calibration compares well with two spectroscopic calibrations. Comparing synthetic calculated iso- metallicity lines with our empirical calibration, we find a good agreement of the shapes and slopes.

    Conclusions. Compared to previous calibrations our new photometric calibration shows improvement in all statistical tests performed. Through our testing of several polynomials we conclude that the inclusion of a cross-term between absolute magnitude and color is important for the performance of the photometric calibration. Applying our photometric calibration to a sample of M dwarfs known to host planets points towards a possible giant planet-metallicity correlation for M dwarfs.

    Keyword
    Stars: low-mass - Techniques: photometric - Planets and satellites: formation
    National Category
    Astronomy, Astrophysics and Cosmology
    Identifiers
    urn:nbn:se:uu:diva-332624 (URN)
    Funder
    Swedish National Space Board
    Available from: 2017-10-31 Created: 2017-10-31 Last updated: 2017-11-01
  • Puettner, R.
    et al.
    Free Univ Berlin, Fachbereich Phys, Arnimallee 14, D-14195 Berlin, Germany..
    Jankala, K.
    Univ Oulu, Nano & Mol Syst Res Unit, POB 3000, Oulu 90014, Finland..
    Kushawaha, R. K.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France..
    Marchenko, T.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Goldsztejn, G.
    Max Born Inst, Max Born Str 2A, D-12489 Berlin, Germany..
    Travnikova, O.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Guillemin, R.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Journel, L.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Ismail, I.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France..
    de Miranda, B. Cunha
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France..
    Lago, A. F.
    Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP, Brazil..
    Ceolin, D.
    Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Piancastelli, Maria Novella
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics. UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France..
    Simon, M.
    UPMC Univ Paris 6, CNRS, UMR 7614, Lab Chim Phys Mat & Rayonnement,Sorbonne Univ, F-75005 Paris, France.;Synchrotron SOLEIL, BP 48, F-91192 Gif Sur Yvette, France..
    Detailed assignment of normal and resonant Auger spectra of Xe near the L edges2017In: Physical Review A: covering atomic, molecular, and optical physics and quantum information, ISSN 2469-9926, E-ISSN 2469-9934, Vol. 96, no 2, 022501Article in journal (Refereed)
    Abstract [en]

    We present a comprehensive experimental and theoretical investigation on the LMM, LMN, and LNN normal Auger spectra of xenon, which reveal excellent agreement with theory when core-hole lifetimes of the two-hole final states are taken into account. Generally, the spectra turned out to be highly complex due to a strong overlap of the Auger transitions subsequent to 2s(1/2)(-1), 2p(1/2)(-1), and 2p(3/2)(-1) ionization. This overlap is due to the splitting of the three initial L core holes and the different final M and N core holes being on the same order of magnitude of several hundred eV. The Auger transitions are assigned in detail based on the theoretical results. Most of the MM, MN, and NN final states are described well based on jj coupling. In addition, we present a detailed assignment of the resonant LM45M45 Auger transition subsequent to the 2s -> 6p, 7p and 2p -> 5d, 6d excitations.

  • Ljungvall, Karl
    et al.
    Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
    Magnusson, Ulf
    Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
    Korvela, Marcus
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Norrby, Mattias
    Swedish Univ Agr Sci, Div Reprod, Dept Clin Sci, Uppsala, Sweden..
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Persson, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Heavy metal concentrations in female wild mink (Neovison vison) in Sweden: Sources of variation and associations with internal organ weights2017In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 36, no 8, 2030-2035 p.Article in journal (Refereed)
    Abstract [en]

    The American mink is an invasive species in Sweden, and it is legally hunted all year. Therefore, the mink is well suited as a sentinel species for environmental monitoring. In the present study female mink (n = 91) from 6 different areas in Sweden were analyzed for the concentrations of silver, cadmium, mercury and lead in liver tissue using inductively coupled plasma mass spectrometry. The wet concentrations in liver tissue were 42.6 +/- 52.7 ng/g for silver, 99.5 +/- 100 ng/g for cadmium, 652 +/- 537 ng/g formercury, and 196 +/- 401 ng/g for lead (expressed as mean + standard deviation). There were associations between the sample area and the concentrations of silver, lead, and mercury. The concentrations of lead and cadmium varied with season of capture and lead, cadmium, and mercury were positively associated with increasing age. Relative liver weight was positively associated with concentrations of mercury and negatively associated with lead and cadmium. Relative kidney weight was negatively associated with lead concentrations. In summary, it is of importance to take age and season of capture into account when assessing levels of heavy metals in wild mink. Also, liver and kidneys seem to be potential targets for heavy metal toxicity in wild female mink in Sweden.

  • Thorander, Birgitta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    "Om inte rektor är engagerad och driver så blir det inget": En intervjustudie om rektorers ledarskap i en statligt styrd skolutvecklingsinsats2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • Public defence: 2017-12-14 09:00 Skoogsalen, Uppsala
    Cederblad, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Aspects on Head and neck Cancer with special reference to Salivary Gland Tumours and Single Nucleotide Polymorphism2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A thesis on Head and neck cancer focusing on dose planning, salivary gland carcinoma and Single nucleotide polymorphism.

    For dose planning PET/CT (Positron emissions tomography/computed tomography) with tracer gave more precise information in comparison dose planning with CT. More primary tumours and metastases were found with the acetate tracer than with glucose tracer. Acetate PET/CT also showed larger volume of tumours attributed to lipid metabolism.

    In a retrospective study salivary gland cancer 5-year overall survival (OS) was 53 %. Salivary gland carcinoma consists of many histopathological groups, the two largest groups being mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ASCC). For ACC, having the best 5-year OS, it was 70 percent. Facial palsy, advanced stage disease, lymph node metastases worsened prognosis. ACC and polymorphous low grade carcinoma (PLGA) expressed c-myc and cyclin D1 to a larger extent than MEC.

    In squamous cell carcinoma of the head and neck we examined the occurrence of Single Nucleotide polymorphism, SNP. We found that the SNPs in male and female patients differed from each other. In male patients the SNPs were associated with immune response while in female patients the association was to SNPs concerning inflammation. This means that different pathways were engaged in cancer development for men and women. We also found that the SNPs in patients were different from those expressed in the healthy controls.

    List of papers
    1. Cancer of the parotid gland; long-term follow-up: A single centre experience on recurrence and survival
    Open this publication in new window or tab >>Cancer of the parotid gland; long-term follow-up: A single centre experience on recurrence and survival
    Show others...
    2009 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 48, no 4, 549-555 p.Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND:

    The aim of the study was to investigate the results of treatment of malignant parotid gland tumours at a single centre during a 56 year period, focusing on tumour control and survival.

    PATIENTS AND METHODS:

    At Uppsala University Hospital, Sweden, 144 patients (73 male and 71 female) with parotid cancer were treated between 1948 and 2004. The mean and median ages were 62 and 65 years, respectively (range 16-89 years). Surgery was the primary treatment in 113 (78%) patients followed by radiotherapy in 81. Postoperative radiotherapy in doses of 64-66 Gy, where the intention was curative and delivered with either split course or not, was administered to a majority of patients after 1970. The split-course mode was practised between 1970 and 1989. The median follow-up time was 8.3 years for patients still alive. There were 57 (40%) relapses, of which 40 were local recurrences with 26 inside the treatment volume.

    RESULTS:

    The overall 5-year survival was 53%. The majority of tumour-related deaths appeared in the first 3-5 years after diagnosis. Age, co-morbidity, the presence of lymph node metastases, adenoid cystic carcinoma and extent of disease were important for outcome; gender, however, was not. We found no difference in the survival between patients following split course therapy versus continuous fractionation. No difference could be seen in the survival of patients treated in the 1970s versus the 1990s.

    CONCLUSIONS:

    Age, nodal engagement, a higher T-stage, adenoid cystic carcinoma histopathology, facial palsy and intercurrent disease worsen the outcome of patients, whereas gender does not. Treatment principles at our hospital have been surgery followed by radiotherapy since the early 1970s even though a split course technique was practised during a part of this period. Survival has not improved markedly. Thus, there is scope for improvement for this group of patients.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-105426 (URN)10.1080/02841860802680419 (DOI)000265272900009 ()19140053 (PubMedID)
    Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2017-10-25Bibliographically approved
    2. The Combined Effects of Single-Nucleotide Polymorphisms, Tobacco Products, and Ethanol on Normal Resting Blood Mononuclear Cells
    Open this publication in new window or tab >>The Combined Effects of Single-Nucleotide Polymorphisms, Tobacco Products, and Ethanol on Normal Resting Blood Mononuclear Cells
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    2013 (English)In: Nicotine & tobacco research, ISSN 1462-2203, E-ISSN 1469-994X, Vol. 15, no 5, 890-895 p.Article in journal (Refereed) Published
    Abstract [en]

    Introduction: Tobacco and ethanol consumption are crucial factors in the development of various diseases including cancer. In this investigation, we evaluated the combined effects of a number of single nucleotide polymorphisms (SNPs), with ethanol and tobacco products on healthy individuals. Methods: Pure nicotine, cigarette smoke extract, and Swedish snuff (snus) extract were used. The effects were examined by means of in vitro cell cycle progression and cell death of peripheral blood mononuclear cells (PBMCs) obtained from healthy donors. Results: After 3 days, in vitro, resting PBMCs entered the S and G2 stage in the presence of 100 mu M nicotine. The PBMCs only proceeded to S stage, in the presence of 0.2% ethanol. The nicotine- and ethanol-induced normal cell cycle progression correlated to a number of SNPs in the IL12RB2, Rad 52, XRCC2, P53, CCND3, and ABCA1 genes. Certain SNPs in Caspases 8, IL12RB2, Rad 52, MMP2, and MDM2 genes appeared to significantly influence the effects of EtOH-, snus-, and snus + EtOH-induced cell death. Importantly, the highest degree of cell death was observed in the presence of smoke + EtOH. The amount of cell death under this treatment condition also correlated to specific SNPs, located in the MDM2, ABCA1, or GASC1 genes. Conclusions: Cigarette smoke in combination with ethanol strongly induced massive cell death. Long-term exposure to smoke and ethanol could provoke chronic inflammation, and this could be the initiation of disease including the development of cancer at various sites.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-200343 (URN)10.1093/ntr/nts207 (DOI)000317796500004 ()
    Available from: 2013-05-28 Created: 2013-05-27 Last updated: 2017-10-25Bibliographically approved
    3. Expression of Cyclin D1 and c-myc in adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low grade carcinoma
    Open this publication in new window or tab >>Expression of Cyclin D1 and c-myc in adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low grade carcinoma
    (English)Manuscript (preprint) (Other academic)
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-332191 (URN)
    Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2017-10-25
    4. Single Nucleotide Polymorphism and Cancer Risk, Tumour Recurrence or Survival of Head & Neck Cancer Patients
    Open this publication in new window or tab >>Single Nucleotide Polymorphism and Cancer Risk, Tumour Recurrence or Survival of Head & Neck Cancer Patients
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    2017 (English)In: OncologyArticle in journal (Refereed) Published
    Abstract [en]

    OBJECTIVE: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&amp;N) cancer patients. METHODS: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&amp;N cancer patients and 245 healthy blood donors were enrolled in the study. RESULTS: Ten SNPs were associated with H&amp;N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFalpha) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival. CONCLUSION: Genetic variation of the TNFalpha rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&amp;N cancer patients.

    Place, publisher, year, edition, pages
    karger, 2017
    Keyword
    Tumor recurrenceSurvival timeSingle-nucleotide polymorphismsHead and neck cancer
    National Category
    Medical and Health Sciences
    Research subject
    Oncology
    Identifiers
    urn:nbn:se:uu:diva-331352 (URN)10.1159/000452278 (DOI)
    Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2017-10-25
    5. 1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: implications for staging and radiotherapy planning
    Open this publication in new window or tab >>1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: implications for staging and radiotherapy planning
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    2007 (English)In: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, E-ISSN 1619-7089, Vol. 34, no 5, 651-657 p.Article in journal (Refereed) Published
    Abstract [en]

    Purpose  The aim of this study was to evaluate the feasibility of using 1-[11C]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using 18F-fluoro-2-deoxy-D-glucose (FDG) PET. Methods  Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases were delineated automatically by using the 50% threshold of maximum radioactivity corrected for background. The mean standardised uptake value (SUV) and the tumour volumes were evaluated and compared. Results  All ten primary tumours were detected by ACE-PET, while nine primaries were detected by FDG-PET and CT and/or MRI. The ACE SUV tended to be lower than the FDG SUV (5.3±2.7 vs 9.6±7.0, p=0.07). The tumour volumes delineated with ACE were on average 51% larger than the FDG volumes (p<0.05). ACE-PET identified 20/21 lymph node metastases, while only 13/21 lesions were detected by FDG-PET and 16/21 lesions by CT or MRI. Conclusion  ACE-PET appears promising for the staging of head and neck cancer. The biological information provided by both FDG and ACE must be carefully validated before it can be used in clinical routine for radiation treatment planning. More studies are needed to evaluate the differences in volumes and to confirm the clinical potential of both FDG and ACE-PET, especially in radiotherapy.

     

    Keyword
    11C-acetate, 18F-FDG, PET, Head and neck cancer, SUV
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-14998 (URN)10.1007/s00259-006-0298-9 (DOI)000246095900005 ()17146654 (PubMedID)
    Available from: 2008-02-01 Created: 2008-02-01 Last updated: 2017-10-25Bibliographically approved
  • Tshering, Phurpa
    et al.
    Royal University of Bhutan, Bhutan.
    Lhamo, Dekar
    Royal University of Bhutan, Bhutan.
    Yu, Lu
    Tongji University, China.
    Berglund, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    How Do First Year Students Learn C Programming in Bhutan?2017In: Proceedings of 2017 International Conference on Learning and Teaching in Computing and Engineering, LaTiCE, IEEE , 2017, 25-29 p.Conference paper (Refereed)
    Abstract [en]

    This study explores how first year students inInformation Technology Engineering at College of Science andTechnology, Royal University of Bhutan, learn C programming.An online questionnaire was administrated to the students andasked about time spent in collaborative learning, individualcoding and watching someone code. These data were analyzed incorrelating to their exam scores. Students’ ways of preparing forexam and their concept on C programming are categorized. Ourresult indicate a relationship between how the different ways ofworking relate to their exam results. Further, the insights of theproject point to that learning of theory of programming andpracticing programming go hand in hand in a C programmingcourse. Our intent is that this study will be helpful for futureteachers and students in programming courses in Bhutan and inits region.

  • Åkerlund, Lisa
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Morgondagens organiska batterier2017Other (Other (popular science, discussion, etc.))
  • Creswell, Philip K.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Ties in Mediated Activism: A Presentation about the Possible Importance of Relationships in Risky Activism Online2016Conference paper (Other academic)
    Abstract [en]

    An individual’s recruitment and commitment to activism has been repeatedly shown to be tied to pre-existing network ties. The riskier or costlier the activism one is involved in, the stronger the ties are expected to be in order to galvanize action. Therefore, embeddedness in social networks and shared social ties are important for theorizing involvement in and commitment to a movement. The nature of these ties, however, is rarely theorized beyond a “weak/strong” axis and this matter is exacerbated by the introduction of computer mediation. This paper assesses the literature of both network theory and social movements, while drawing on work about mediated emotions. I suggest that understanding the content of social ties—that is, shared emotional intensity, intimacy, frequency of contact and reciprocity—may be important to understanding engagement in mediated high-cost or high-risk activities.

  • Westerberg, Jacob
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control.
    A deep learning approach for action classification in American football video sequences2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The artificial intelligence is a constant topic of conversation with a field of research that is pushed forward by some of the world's largest companies and universities. Deep learning is a branch of machine learning within artificial intelligence based on learning representation of data such as images and texts by processing the data through deep neural networks. Sports are competitive businesses that over the years have become more data driven. Statistics play a big role in the development of the practitioners and the tactics in order to win. Sport organizations have big statistic teams since statistics are manually obtained by these teams. To learn a machine to recognize patterns and actions with deep learning would save a lot of time. In this thesis a deep learning approach is used to examine how well it can perform to classify the actions pass and run in American footbal lgames. A deep learning architecture is first trained and developed on a public video dataset and then trained to classify run and pass plays on a new American football dataset called the All-22 dataset. Results and earlier research show that deep learning has potential to automatize sport statistic but is not yet ready to overtake the role statistic teams have. Further research, bigger and more task specific datasets and more complex architectures are required to enhance the performance of this specific type of deep learning based video recognition.

  • Voilley, Gabrielle
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Rogne, Ida
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Socialt kapitals påverkan på internationalisering: En fallstudie av små och medelstora företags internationalisering2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Vid uppstart kan små och medelstora företag ha begränsade resurser, vilket i sin tur kan påverka företagens möjlighet att internationalisera. Resurser och kunskap är två förutsättningar för att kunna internationalisera, och erhålls bland annat genom socialt kapital. Om det sociala kapitalet spelar en viktig roll vid en internationalisering, är frågan hur det påverkar små och medelstora företag. Intervjuer genomfördes med VD:ar, grundare samt en exportchef på fem olika företag för att undersöka hur företagen har internationaliserat, samt vilken roll det sociala kapitalet har spelat. Resultatet visar att inte alla företag behöver ha en initial vilja eller socialt kapital för att genomföra en internationalisering. En god relation med samarbetspartners är dock nödvändig för att fortsätta expandera och öka omfattningen av den internationella verksamheten. Resultatet visar också att det kan finnas olika faser vid en internationalisering, och att dessa kan vara bra att känna till för företag för att underlätta en fortsatt internationalisering och skapa en stabilare verksamhet på de utländska marknaderna. 

  • Flink, Mathias Gustaf
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Beling, Carl
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Food for thought: A study on the digitalization of restaurant interactions2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study is grounded in the evolving perspective of Service Marketing, Service-Dominant-Logic and ServiceLogic and aims to provide a holistic view of how the digitalization of interactions affects the service provided by the restaurant and in turn the customers’ value creation processes. More exactly, the study examines a digital system for information exchange, order placements and payments in a restaurant on the Swedish market. The study adopts a qualitative approach and data has been collected through the use of unstructured observations and semi-structured interviews. The findings are that the system for digital interactions has both positive and negative effects on valuecreation. It also changes other aspects of the service not directly linked to the system. If this ultimately creates more or less value for the customers is believed to depend on the customers’ individual differences, but if the system is used as a complement to the already existing service rather than as a substitute of the human interaction there are opportunities for a successful implementation. 

  • Lund, Allan A.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Lidt om arkæologi og racisme1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 357-360 p.Article in journal (Other academic)
  • Edberg, Rune
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Tesch, Sten
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Nyfunna skeppsbilder från 1100-talet i Sigtuna1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 305-312 p.Article in journal (Other academic)
  • Juma, Abdurahman
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Muslim Burial Customs on the East African coast.1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 249-356 p.Article in journal (Other academic)
  • Notelid, Michel
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, African and Comparative Archaeology.
    Vetenskap och religion i negativ dialog1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 313-348 p.Article in journal (Other academic)
  • Herschend, Frands
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    A Note on Late Iron Age Kingship Mythology1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, 283-304 p.Article in journal (Other academic)
  • Brink, Stefan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Political and Social Structures in Early Scandinavia: A Settlement-historical Pre-study of the Central Place1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 235-282 p.Article in journal (Other academic)
  • Hedeager, Lotte
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Myter og materiel kultur: Den nordiske oprindelsesmyte i det tidlige kristne Europa1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 217-234 p.Article in journal (Other academic)
  • Herschend, Frands
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Verses for Lupus, Duke of Champagne. Four Poems by Venantius Fortunatus1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, 209-2016 p.Article in journal (Other academic)
  • Flemberg, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History.
    Four Poems by Venantius Fortunatus concerning Duke Lupus. Translated into Swedish and English1996In: Tor: meddelanden från Uppsala universitets museum för nordiska fornsaker, ISSN 0495-8772, Vol. 28, 189-208 p.Article in journal (Other academic)
  • Public defence: 2017-12-15 18:25
    Amvrosiadi, Nino
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    The value of experimental data and modelling for exploration of hydrological functioning: The case of a till hillslope2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Successfully modeling one system response (e.g. hydrograph or solute transport) sometimes gives the false sense of well-characterizing the modeled system. This is partly because of the well-known equifinality issue; during the calibration process multiple parameter combinations can produce similarly good results. One step forward towards a better-defined system is using measured (at relevant scale) values for the model parameters, as well as using multiple conditions to constrain the model.

    But when not enough, or relevant, field measurements are available, virtual experiments (VE’s) can be used as a supplementary method to model calibration. The advantage of VE’s over model calibration is that they can also be used to explore assumptions both on the system hydrological processes, and on the model structure.

    One goal of this study was to utilize both field measurements and models for better characterization of the S-transect hillslope, located in Västrabäcken catchment, Northern Sweden. This included (a) characteristics in space: system vertical boundaries, hydraulic parameters, pore water velocity distribution, spatial correlation of flowpaths, soil water retention properties; (b) characteristic of system’s dynamic behavior: storage – discharge relationship, transit time distribution, turnover time; and (c) outputs’ sensitivity to external forcing, and to small scale structure assumptions. The second goal was to comment on the value of field measurements and virtual experiments for extracting information about the studied system.

    An intensely monitored study hillslope was chosen for this work. Although the hillslope has already been the subject of multiple field and modelling studies, there are still open questions regarding the characteristics listed above. The models used were the Vertical Equilibrium Model (VEM), and the Multiple Interacting Pathways (MIPs) model.

    It was found that the hillslope was well connected; from the near-stream areas up to the water divide the storage – discharge relationship could be described as an exponential function. Also, the dynamic storage (which controls the hydrograph dynamics) was much smaller comparing to the total hillslope storage. The unsaturated soil storage was found to be more sensitive to water table positions than vertical flux magnitude. The dynamic condition of external forcing (precipitation and evapotranspiration) affected the transit time distribution (TTD) shape. And, opposite to expectations, TTD was not sensitive to micro-scale structural assumptions tested here.

    List of papers
    1. Water storage dynamics in a till hillslope: the foundation for modeling flows and turnover times
    Open this publication in new window or tab >>Water storage dynamics in a till hillslope: the foundation for modeling flows and turnover times
    2016 (English)In: Hydrological Processes, ISSN 0885-6087, E-ISSN 1099-1085, Vol. 31, no 1, 4-14 p.Article in journal (Refereed) Published
    Keyword
    flow pathways, storage, storage dynamics, turnover time
    National Category
    Earth and Related Environmental Sciences
    Identifiers
    urn:nbn:se:uu:diva-331679 (URN)10.1002/hyp.11046 (DOI)
    Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-11-14
    2. Soil moisture storage estimation based on steady vertical fluxes under equilibrium
    Open this publication in new window or tab >>Soil moisture storage estimation based on steady vertical fluxes under equilibrium
    2017 (English)In: Journal of Hydrology, Vol. 553, 798-804 p.Article in journal (Refereed) Published
    Keyword
    Volumetric soil water content, Vertical flux, VEM, Catchment water storage
    National Category
    Oceanography, Hydrology, Water Resources
    Identifiers
    urn:nbn:se:uu:diva-331688 (URN)10.1016/j.jhydrol.2017.08.042 (DOI)
    Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-11-14
    3. Value of virtual experiments for a hillslope scale system understanding
    Open this publication in new window or tab >>Value of virtual experiments for a hillslope scale system understanding
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Oceanography, Hydrology, Water Resources
    Identifiers
    urn:nbn:se:uu:diva-331730 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-11-14
    4. Water age dependence on vertical flux assumptions
    Open this publication in new window or tab >>Water age dependence on vertical flux assumptions
    (English)Manuscript (preprint) (Other academic)
    National Category
    Oceanography, Hydrology, Water Resources
    Identifiers
    urn:nbn:se:uu:diva-331731 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-11-14
    5. Following tracer through the unsaturated zone using a Multiple Interacting Pathways model: implications from laboratory experiments
    Open this publication in new window or tab >>Following tracer through the unsaturated zone using a Multiple Interacting Pathways model: implications from laboratory experiments
    (English)Manuscript (preprint) (Other academic)
    National Category
    Oceanography, Hydrology, Water Resources
    Identifiers
    urn:nbn:se:uu:diva-331732 (URN)
    Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-11-14
  • Kättström, Maria
    Grounding of distrubution grids: High impedancegrounding compared to solid grounding with Fault Current Limiter2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Today cables replace overhead lines in distribution systems and

    cause higher system capacitance and higher capacative fault

    currents. This fault current, in the fault location, is limited by a

    Petersén coil and a resistance in parallel when a fault occurs in so

    called “high impedance grounded systems” which are commonly used in

    Europe. The high impedance however has the disadvantage that it

    needs to be adjusted to the capacitance in the system in order to

    optimize the limitation of the fault current.

    Another option is to use a solidly grounded system with a so called

    “Fault Current Limiter” (FCL) instead, on the outgoing terminals of

    the transformer feeding the system. The FCL interrupts the outgoing

    current on the load side of the transformer that feeds the system,

    in case of a fault, by forcing the current to a zero with a counter

    voltage. The FCL in this master thesis triggers on 1.5 times higher

    current than nominal current. After fault clearing the FCL is

    reclosed. The FCL has the advantage that it does not have to be

    adapted to the capacitance in the system. It should be noted that

    the current in all of the phases (even the healthy phases) are

    interrupted downstream the FCL. It also has the ability to interrupt

    the single line-to-ground fault before it develops into a three

    phase fault.

    This thesis presents a comparison between the high impedance

    grounding and the FCL. The characteristics of the two grounding

    principles are investigated in a distribution system from

    Vattenfall. The assessment is done via simulations in the program

    PSCAD with three types of grounding of the transformer; high

    impedance grounding, solid grounding (without FCL) and solid

    grounding with FCL. The system is simulated with the faults “single

    line-to-ground” and “three phase short circuit” respectively, even

    if a line-to-line can occur. The results from the simulations show

    that the FCL gives a short fault duration time and a possibility to

    limit both single line-to-ground faults and three phase faults. The

    high impedance grounding on the other hand is able to limit single

    line-to-ground faults whereas it is generally known that not able to

    limit three phase short circuits.

  • Aad, G.
    et al.
    CPPM, Aix-Marseille Université and CNRS/IN2P3MarseilleFrance.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isaksson, Charlie
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pelikan, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Topological cell clustering in the ATLAS calorimeters and its performance in LHC Run 12017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 7, 490Article in journal (Refereed)
    Abstract [en]

    Event-shape observables measured using charged particles in inclusive Z-boson events are presented, using the electron and muon decay modes of the Z bosons. The measurements are based on an integrated luminosity of 1.1 fb(-1) of proton-proton collisions recorded by the ATLAS detector at the LHC at a centre-of-mass energy root s = 7 TeV. Charged-particle distributions, excluding the lepton-antilepton pair from the Z-boson decay, are measured in different ranges of transverse momentum of the Z boson. Distributions include multiplicity, scalar sum of transverse momenta, beam thrust, transverse thrust, spherocity, and F-parameter, which are in particular sensitive to properties of the underlying event at small values of the Z-boson transverse momentum. The measured observables are compared with predictions from PYTHIA 8, Sherpa, and HERWIG 7. Typically, all three Monte Carlo generators provide predictions that are in better agreement with the data at high Z-boson transverse momenta than at low Z-boson transverse momenta, and for the observables that are less sensitive to the number of charged particles in the event.

  • Loeb, Stacy
    et al.
    NYU, Dept Urol, New York, NY USA.;NYU, New York, NY USA.;Manhattan VA, New York, NY USA..
    Ventimiglia, Eugenio
    IRCCS Osped San Raffaele, Div Expt Oncol, Unit Urol, URI, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.;Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden..
    Salonia, Andrea
    IRCCS Osped San Raffaele, Div Expt Oncol, Unit Urol, URI, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy..
    Folkvaljon, Yasin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Umea Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden..
    Meta-Analysis of the Association Between Phosphodiesterase Inhibitors (PDE5Is) and Risk of Melanoma2017In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 109, no 8, djx086Article in journal (Refereed)
    Abstract [en]

    The US Food and Drug Administration recently announced the need to evaluate the association between PDE5is and melanoma. We performed a meta-analysis on the association between PDE5i and melanoma using random effects models and examined whether it met Hill's criteria for causality. A systematic search of Medline, EMBASE, and the Cochrane Library from 1998 to 2016 identified three case-control studies and two cohort studies, including a total of 866 049 men, of whom 41 874 were diagnosed with melanoma. We found a summary estimate indicating an increased risk of melanoma in PDE5i users (relative risk = 1.12, 95% confidence interval = 1.02 to 1.23). However, there was no difference in risk between men with low and high exposure to PDE5i, and risk was higher for in situ melanoma than localized and high-risk melanoma, suggesting a lack of dose response and biological gradient. PDE5i use was also associated with basal cell cancer, suggesting a lack of specificity and likely confounding by ultraviolet exposure. Thus, although this meta-analysis found a statistically significant association between PDE5i and melanoma, it did not satisfy Hill's criteria for causality.

  • Public defence: 2017-12-08 10:15 Brusewitz-salen, Uppsala
    Karlén, Niklas
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Sponsors of War: State Support for Rebel Groups in Civil Conflicts2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Many civil wars are illustrative of wider international tensions and connections that transcend state borders. States often intervene to influence the trajectory and outcome of civil conflicts by providing external support to warring parties. This assistance ranges from direct military intervention to the provision of weapons, training, funds, safe havens, intelligence, logistics and other critical resources. This dissertation contains four individual essays that each seeks to advance our knowledge of state support to rebel movements. The first essays (I and II) add to our understanding of how external state support influences conflict dynamics while the latter (III and IV) begin to unpack the political decision-making process behind decisions that alter the original support commitment. Essay I evaluates whether state support to rebels increases the probability of civil war negotiations being initiated. The findings question a widespread belief among policymakers that support can foster negotiations. Essay II explores if external support influences the risk of conflict recurrence. It finds that state support to rebels can increase the risk of conflict recurrence in the short-term while there is no equivalent effect of support provided to governments. Essay III is the first global analysis of support termination and it thereby opens up an entirely new research field. The results suggest that the causes related to the initiation of support and its termination are largely distinct while the transition from the Cold War and the absence of ethnic kinship ties offer some insights into when states are more likely to terminate support. Essay IV unpacks the political decision-making process of the United States’ support to the armed opposition in Nicaragua in the 1980s and in Syria in the 2010s. The results indicate that adverse feedback functions as a trigger for increasing previous commitments as long as policy failure can be attributed to external actors, while reduced support is often a result of attributing failure to the state sponsor’s own actions. Taken together, the essays make significant contributions to advance our understanding of biased third-party interventions, conflict recurrence, civil war negotiations, foreign policy decision-making and state sponsorship of terrorism.

    List of papers
    1. Escalate to De-Escalate? External State Support and Governments’ Willingness to Negotiate
    Open this publication in new window or tab >>Escalate to De-Escalate? External State Support and Governments’ Willingness to Negotiate
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Policymakers frequently claim that military assistance to rebels can force governments into negotiations. Many seem convinced that providing material assistance to rebels involved in a civil war can create a ‘ripe moment’ that is favorable for negotiations and thus offer an attractive path towards a negotiated settlement. However, this widespread belief has never been systematically assessed. This article evaluates this claim using global data on negotiations in all intrastate armed conflicts from 1975 to 2009. Contrary to conventional wisdom, the article demonstrates that external state support to rebel groups does not increase the prospect of negotiations. Neither sustained pressure, support provided by great powers, nor direct military intervention increases the probability of negotiations being initiated. Instead, the results suggest that external support is likely to reduce the likelihood of negotiations between the warring parties, especially if the state sponsor is a great power. The study contributes to our understanding of civil war processes by demonstrating that military assistance hinders rather than promotes the onset of negotiations.

    Keyword
    Interventions, external support, negotiations, civil war, military pressure
    National Category
    Political Science (excluding Public Administration Studies and Globalization Studies)
    Research subject
    Peace and Conflict Research
    Identifiers
    urn:nbn:se:uu:diva-331866 (URN)
    Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-10-19
    2. The legacy of foreign patrons: External state support and conflict recurrence
    Open this publication in new window or tab >>The legacy of foreign patrons: External state support and conflict recurrence
    2017 (English)In: Journal of Peace Research, ISSN 0022-3433, E-ISSN 1460-3578, Vol. 54, no 4, 499-512 p.Article in journal (Refereed) Published
    Abstract [en]

    Why do some armed conflicts that have ended experience renewed fighting while others do not? Previous research onconflict recurrence has approached this question by looking at domestic factors such as how the war was fought, howit ended or factors associated with its aftermath. With the exception of the literature on third-party securityguarantees, the influence of outside actors has often been overlooked. This article explores the role of external statesand suggests when and how their involvement is likely to affect the probability of renewed warfare. The mainargument is that the legacy of outside support creates an external support structure that affects the previouscombatants’ willingness as well as their opportunities to remobilize. This means that armed conflicts with externalstate support will experience a greater likelihood of recurrence compared to other conflicts which did not see externalsupport. The theory is tested using Cox proportional hazards models on global data of intrastate armed conflicts1975–2009. The findings suggest that external support to rebels increases the risk of conflict recurrence in the shortterm as groups receive or anticipate renewed assistance. The results also indicate that it is more important for rebelgroups to have had enduring support over the years in the previous conflict rather than access to multiple statesponsors. External support provided to governments is not associated with conflict recurrence.

    Keyword
    civil war, conflict recurrence, external support, third party interventions, state sponsorship, external state support
    National Category
    Political Science (excluding Public Administration Studies and Globalization Studies)
    Identifiers
    urn:nbn:se:uu:diva-323527 (URN)10.1177/0022343317700465 (DOI)
    Available from: 2017-06-07 Created: 2017-06-07 Last updated: 2017-10-19Bibliographically approved
    3. Turning off the Taps: The Termination of State Sponsorship
    Open this publication in new window or tab >>Turning off the Taps: The Termination of State Sponsorship
    2017 (English)In: Terrorism and Political Violence, ISSN 0954-6553, E-ISSN 1556-1836Article in journal (Refereed) Epub ahead of print
    Abstract [en]

    Why do some states terminate their sponsorship of rebel movements while others are persistent in their provision of support? In the past, most research on external support to insurgents has focused on why states choose to sponsor rebel groups and particularly how this affects conflict duration. However, we know little about the termination of such support. This is surprising given that support has been shown to make armed conflicts more intractable and tremendous efforts are made in condemning and sanctioning such behavior. This study constitutes the first large-N analysis of support termination, employing survival analysis on global data of state support to rebel movements between 1975–2009. Surprisingly, the findings indicate that only some of the factors that explain support provision can offer insights into its termination. In particular, support is more likely to be terminated when no ethnic kinship bonds exist between the rebel movement and the government of the supporting state. Many decisions to withdraw support also seem to coincide with the transition from the Cold War. Threats and sanctions from other states appear largely ineffective. The study contributes to our understanding of the international dimensions of civil war and the role and motives of third parties.

    Keyword
    external support termination, state sponsorship, rebel patronage, third party interventions, international dimensions of civil war
    National Category
    Political Science (excluding Public Administration Studies and Globalization Studies)
    Research subject
    Peace and Conflict Research
    Identifiers
    urn:nbn:se:uu:diva-317046 (URN)10.1080/09546553.2017.1282861 (DOI)
    Available from: 2017-03-09 Created: 2017-03-09 Last updated: 2017-10-19
    4. Changing Commitments: US Support to Rebels in Syria and Nicaragua
    Open this publication in new window or tab >>Changing Commitments: US Support to Rebels in Syria and Nicaragua
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The provision of external state support to non-state actors in civil wars is a dynamic process. The calculus of state sponsors varies over time, which means that assistance provided to the armed opposition fluctuates. This is rarely recognized in existing research, which has focused more on the initiation of support and its subsequent effects on conflict dynamics. While we know many of the motives behind decisions to provide support, we know less about why state sponsorship of rebels changes over time. To address this, I propose a theoretical argument that is able to account for policy adjustments over time. The theory builds on the notion that leaders change their support commitment when there is adverse feedback and that support increases as long as the causes of policy failure can be attributed to external actors, while cutbacks occur when failure is attributed to the state sponsor’s own actions. The latter prompts domestic audiences to act in order to force leaders to back down. Process tracing is used to explore the value of this framework in within-case analyses of the United States’ support commitments to insurgent groups in Nicaragua during the 1980s and in Syria during the 2010s. The study demonstrates the utility of focusing on shifts in leaders’ perceptions rather than structural features of the international system or rebel behavior to understand temporal variation in external support.

    Keyword
    external support, state sponsorship, civil war, US foreign policy, Syria, Nicaragua
    National Category
    Political Science (excluding Public Administration Studies and Globalization Studies)
    Research subject
    Peace and Conflict Research
    Identifiers
    urn:nbn:se:uu:diva-331867 (URN)
    Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-10-19
  • Rensing, Merlin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Enzymatic cleavage of HMGB12017Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Alarmins and damage associated molecular pattern (DAMP) are endogenous proteins with distinct and various intracellular roles that when released extracellularly act as startingsignals for inflammatory immune responses. The endogenous protein High mobility group box 1 (HMGB1) acts as a DAMP and has been shown to drive progression of multiple inflammatory and autoimmune diseases. During homeostasis HMGB1 is localized in the nucleus of almost any cell, where its main function is organization of the DNA and regulation of transcription. Upon cell death or immune cell activation HMGB1 can be translocated into the cytoplasm for subsequent release into the extracellular space. Extracellular HMGB1 can act as a DAMP by activating several receptors of the immune system. Recent studies focus on HMGB1 release and functional regulation due to prost-translational modifications (PTMs) on cysteine residues. However, little is known about enzymatic regulation of HMGB1. The aim of this thesis was to investigate the possibility of proteolytic processing of HMGB1 by enzymes, which play a crucial role in inflammatory diseases and their progression. We utilized an in vitro model that mimics natural conditions of the autoimmune disease arthritis. Enzymatic digestion of HMGB1 was performed in kinetics studies using the neutrophilic enzymes cathepsin G, neutrophil Elastase as well as matrix metalloproteinase-3, which is released from tissues at the site of inflammation. We defined that HMGB1 is a novel substrate of all of the tested enzymes. All enzymes induced different cleavage pattern. In conclusion, my findings open up the possibility for future studies involving the observed fragments of HMGB1 and their functional features. It also demonstrated that HMGB1 is affected by protease modifications in a disease relevant environment.

  • Stångberg, Josefine
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    The evolution of sexual dimorphism in life history traits2017Report (Other academic)
    Abstract [en]

    Many dioecious organisms exhibit some level of sexual dimorphism; the sexes can differ in phenotype, and can have different fitness optima for certain traits and have different reproductive strategies. Sex-specific selection, thus, can be highly diverging in both magnitude and direction. When selection for a trait differs in direction we have antagonistic selection; this often leads to sexual conflicts since the two sexes share most of their genetic architecture. Sexual dimorphism is often seen as a resolution to sexual conflict, a way to decouple the genetic basis of traits under conflict and allow sex-specific expression. One way to better understand the evolution of sexual dimorphism is using a life history theory framework; where traits linked to growth, reproduction and survival are studied and quantified. These quantitative traits, their genetic architecture and how they covary within and between the two sexes, can be further studied using a quantitative genetics approach – G and B matrices. These are essentially genetic variance-covariance matrices of all traits measured, pairwise comparisons that give a picture of how these traits coevolve within an individual (G), but also how different traits covary between the sexes (B). These tools allow us to understand the underlying genetic architecture of life history traits, and also how these traits change under different and sex-specific selection pressures. This, in turn, will aid our understanding of how sexual dimorphism evolves. I end this review by focusing on a particular model species for studying these questions; the nematode Caenorhabditis remanei. 

  • Public defence: 2017-12-14 13:00 Konferensrummet Arbets- och miljömedicin, Uppsala
    Palm, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Methods to assess physical load at work: With a focus on the neck and upper extremities2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    To prevent work-related musculoskeletal disorders (MSDs), useful, reliable and valid methods for assessing physical workload and risks for MSDs are needed. Ergonomists often assess work by short visual observations without a specific tool. A branch-specific tool was developed for assessing working technique during cash register work (BAsiK observation protocol).

    Inclinometers are an alternative for assessing upper arm postures - over several days. Ergonomists need guidelines explaining how to analyze and interpret such data.

    The aim was to examine and investigate methods for assessing physical load at work, with focus on the neck and upper extremities.

    In Paper:

    I, the reliability and criterion validity of the BAsIK observation protocol were assessed.

    II, the reliability of risk assessments of repetitive work, based on visual observations performed by 21 ergonomists without a specific tool, was assessed.

    III, whole-day inclinometer measurements of upper arm elevation were compared between work and leisure, across 13 different occupations – before and after arm elevations during sitting time was excluded.

    IV, the association between inclinometer-based upper arm elevation and neck/shoulder pain was assessed among 654 blue-collar workers.

     

    The intra-observer reliability of the BAsIK protocol was deemed acceptable, but only 3 of 10 questions in the protocol showed acceptable inter-observer reliability, and 3 showed acceptable criterion validity.

    Neither the inter- or intra-observer reliability of risk assessment without any specific method was acceptable for any upper body regions.

    None of the occupation groups, in paper III, had higher proportion of time with arm elevation during work than leisure. However, when arm elevation during sitting was excluded, 8 occupation groups had higher proportion of time with elevated arms during work than leisure.

    Whole-workday inclinometer-based upper arm elevation was not associated with neck/shoulder pain within the assessed population.

       The results indicate that, in most cases, a single visual observation of a work sequence is not a reliable means of assessing repetitive work. A large proportion of arm elevation may derive from sitting time. At low exposure levels, arm elevation per se may not be a risk factor for neck/shoulder pain.

    This must be taken into account when evaluating the risk for MSDs.

    List of papers
    1. Reliability and criterion validity of an observation protocol for working technique assessments in cash register work
    Open this publication in new window or tab >>Reliability and criterion validity of an observation protocol for working technique assessments in cash register work
    2016 (English)In: Ergonomics, ISSN 0014-0139, E-ISSN 1366-5847, Vol. 59, no 6, 829-839 p.Article in journal (Refereed) Published
    Abstract [en]

    We evaluated the intra- and inter-observer reliability and criterion validity of an observation protocol, developed in an iterative process involving practicing ergonomists, for assessment of working technique during cash register work for the purpose of preventing upper extremity symptoms. Two ergonomists independently assessed 17 15-min videos of cash register work on two occasions each, as a basis for examining reliability. Criterion validity was assessed by comparing these assessments with meticulous video-based analyses by researchers. Intra-observer reliability was acceptable (i.e. proportional agreement >0.7 and kappa >0.4) for 10/10 questions. Inter-observer reliability was acceptable for only 3/10 questions. An acceptable inter-observer reliability combined with an acceptable criterion validity was obtained only for one working technique aspect, 'Quality of movements'. Thus, major elements of the cashiers' working technique could not be assessed with an acceptable accuracy from short periods of observations by one observer, such as often desired by practitioners. Practitioner Summary: We examined an observation protocol for assessing working technique in cash register work. It was feasible in use, but inter-observer reliability and criterion validity were generally not acceptable when working technique aspects were assessed from short periods of work. We recommend the protocol to be used for educational purposes only.

    Keyword
    Repetitivt arbete, muskeloskeletala besvär
    National Category
    Other Medical Sciences not elsewhere specified Environmental Health and Occupational Health
    Identifiers
    urn:nbn:se:uu:diva-276838 (URN)10.1080/00140139.2015.1098734 (DOI)000380150600010 ()26538287 (PubMedID)
    Funder
    Swedish Retail and Wholesale Development Council, 2008:2
    Available from: 2016-02-16 Created: 2016-02-16 Last updated: 2017-10-19
    2. Inter- and intra-observer reliability of risk assessment of repetitive work without an explicit method
    Open this publication in new window or tab >>Inter- and intra-observer reliability of risk assessment of repetitive work without an explicit method
    2017 (English)In: Applied Ergonomics, ISSN 0003-6870, E-ISSN 1872-9126, Vol. 62, 1-8 p.Article in journal (Refereed) Published
    Abstract [en]

    A common way to conduct practical risk assessments is to observe a job and report the observed long term risks for musculoskeletal disorders. The aim of this study was to evaluate the inter- and intra-observer reliability of ergonomists' risk assessments without the support of an explicit risk assessment method. Twenty-one experienced ergonomists assessed the risk level (low, moderate, high risk) of eight upper body regions, as well as the global risk of 10 video recorded work tasks. Intra-observer reliability was assessed by having nine of the ergonomists repeat the procedure at least three weeks after the first assessment. The ergonomists made their risk assessment based on his/her experience and knowledge. The statistical parameters of reliability included agreement in %, kappa, linearly weighted kappa, intraclass correlation and Kendall's coefficient of concordance. The average inter-observer agreement of the global risk was 53% and the corresponding weighted kappa (K-w) was 0.32, indicating fair reliability. The intra-observer agreement was 61% and 0.41 (K-w). This study indicates that risk assessments of the upper body, without the use of an explicit observational method, have non-acceptable reliability. It is therefore recommended to use systematic risk assessment methods to a higher degree.

    Keyword
    Inter-observer reliability, Intra-observer reliability, Risk assessment, Observational methods
    National Category
    Environmental Health and Occupational Health
    Identifiers
    urn:nbn:se:uu:diva-276859 (URN)10.1016/j.apergo.2017.02.004 (DOI)000401206600001 ()28411720 (PubMedID)
    Funder
    Forte, Swedish Research Council for Health, Working Life and Welfare, 1212-1202
    Note

    Title in thesis list of papers: Inter- and intra-observer reliability of risk assessment of repetitive work without any specific method

    Available from: 2016-02-16 Created: 2016-02-16 Last updated: 2017-10-19Bibliographically approved
    3. Exposure to upper arm elevation during work compared to leisure among 13 different occupations measured with tri-axial accelerometers
    Open this publication in new window or tab >>Exposure to upper arm elevation during work compared to leisure among 13 different occupations measured with tri-axial accelerometers
    Show others...
    (English)In: Annals of work exposures and health, ISSN 2398-7308Article in journal (Refereed) Submitted
    Place, publisher, year, edition, pages
    Oxford University Press
    Keyword
    ergonomics, leisure, occupation, arm elevation, inclinometer, measurement strategy, neck and shoulder load, risk assessment
    National Category
    Environmental Health and Occupational Health
    Research subject
    Occupational and Environmental Medicine
    Identifiers
    urn:nbn:se:uu:diva-329790 (URN)
    Available from: 2017-09-21 Created: 2017-09-21 Last updated: 2017-10-19
    4. Whole workday measurements of arm elevation and associations with neck shoulder pain among blue-collar workers in the DPHACTO cohort
    Open this publication in new window or tab >>Whole workday measurements of arm elevation and associations with neck shoulder pain among blue-collar workers in the DPHACTO cohort
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    (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474Article in journal (Refereed) Submitted
    Place, publisher, year, edition, pages
    BioMed Central
    Keyword
    Neck and shoulder pain, arm elevation, inclinometer, occupational, work load, musculoskeletal disorders, cleaners, manufacturing workers, transportation workers
    National Category
    Environmental Health and Occupational Health
    Research subject
    Occupational and Environmental Medicine
    Identifiers
    urn:nbn:se:uu:diva-329797 (URN)
    Funder
    AFA Insurance, 150035
    Available from: 2017-09-21 Created: 2017-09-21 Last updated: 2017-10-19
  • Public defence: 2017-12-08 10:00 Hambergsalen, Uppsala
    Klonowska, Iwona
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Deep subduction of the Seve Nappe Complex in the Scandinavian Caledonides2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis seeks to improve our understanding of the processes involved in continental collision zones, with a particular focus on subduction-exhumation. The main objective of this work has been to define the tectonometamorphic evolution of the deeply subducted Seve Nappe Complex (SNC) in the Scandinavian Caledonides. I utilize mineralogy, petrology and geochronology to constrain the P-T-t paths of the SNC rocks in Sweden.

    The research has focused on the high grade rocks of the SNC and resulted in the discovery of metamorphic diamonds within the gneisses in west-central Jämtland and southern Västerbotten. Microdiamonds provided evidence for the ultra-high pressure metamorphism (UHPM) and subduction of continental rocks to mantle depths. The UHPM in these rocks was confirmed by calculations of the P-T conditions. The UHPM is further recorded by eclogites and garnet pyroxenites from northern Jämtland and eclogites from Norrbotten. All these findings provide compelling evidence for regional UHPM of vast parts of the SNC (at least 400 km along the strike of this allochthonous unit). The SNC rocks followed nearly isothermal decompression paths and paragneisses have locally experienced partial melting during exhumation. Formation of the peculiar Ba- and Ti-enriched dark mica in the Tväråklumparna metasediments is related to the latter stage.

    In-situ monazite dating of the diamond-bearing gneisses from west-central Jämtland supports previous geochronological data inferring that the peak of metamorphism is probably Middle Ordovician and was followed by Early Silurian partial melting. The exact timing of the UHPM here still remains to be resolved. The Lu-Hf garnet and U-Pb zircon dating of eclogite and gneiss from northern Jämtland confirms the Middle Ordovician age of the UHP-HP metamorphism of the SNC rocks. The chemical dating of monazite from the Marsfjället gneiss suggests an earlier UHP history of the Seve rocks in southern Västerbotten as a post-UHP uplift is dated to ca. 470 Ma.

    Based on the P-T-t data obtained in this thesis, particularly on the evidence for Middle Ordovician UHPM and subsequent Silurian exhumation, a new tectonic model for the Scandinavian Caledonides has been proposed. The outcomes of this thesis therefore improve our understanding of the tectonometamorphic history of the Caledonides.

    List of papers
    1. Microdiamond discovered in the Seve Nappe (Scandinavian Caledonides) and its exhumation by the "vacuum-cleaner" mechanism
    Open this publication in new window or tab >>Microdiamond discovered in the Seve Nappe (Scandinavian Caledonides) and its exhumation by the "vacuum-cleaner" mechanism
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    2014 (English)In: Geology, ISSN 0091-7613, E-ISSN 1943-2682, Vol. 42, no 12, 1107-1110 p.Article in journal (Refereed) Published
    Abstract [en]

    When a continent collides with an island arc or other continent, continental crust of the subducted continent may be buried to depths exceeding 100 km, and exposed to pressures that can cause formation of coesite and diamond. This process leads to substantial density increase in SiO2-rich rocks and, in turn, to a reduction of the buoyancy of the subducted material, which should inhibit exhumation. Nevertheless, coesite- and diamond-bearing continental crustal rocks are known from several occurrences worldwide. We report on the discovery of microdiamond in kyanite-garnet gneiss from allochthonous metasediments of the Seve Nappe Complex in the Scandinavian Caledonides. Our discovery calls for general reconsideration of existing exhumation models of deeply subducted continental crust. We propose that the diamond-bearing rocks were subducted in an arc-continent collision setting, and their exhumation was facilitated by local pressure reduction resulting from extraction of the forearc lithospheric block.

    National Category
    Geology Geosciences, Multidisciplinary
    Research subject
    Earth Science with specialization in Mineral Chemistry, Petrology and Tectonics
    Identifiers
    urn:nbn:se:uu:diva-240073 (URN)10.1130/G36108.1 (DOI)000345440600021 ()
    Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2017-10-30Bibliographically approved
    2. Eclogite and garnet pyroxenite from Stor Jougdan, Seve Nappe Complex, Sweden: implications for UHP metamorphism of allochthons in the Scandinavian Caledonides
    Open this publication in new window or tab >>Eclogite and garnet pyroxenite from Stor Jougdan, Seve Nappe Complex, Sweden: implications for UHP metamorphism of allochthons in the Scandinavian Caledonides
    Show others...
    2016 (English)In: Journal of Methamorphic Geology, Vol. 34, no 2, 103-119 p.Article in journal (Refereed) Published
    Abstract [en]

    Ultrahigh-pressure metamorphism (UHPM) has recently been discovered in far-travelled allochthons of the Scandinavian Caledonides, including finding of diamond in the Seve Nappe Complex. This UHPM of Late Ordovician age is older and less recognized than that in the Western Gneiss Region of southwestern Norway, which was related to terminal collision between Baltica and Laurentia. Here we report new evidence of UHPM in the Lower Seve Nappe, recorded by eclogite and garnet pyroxenite from the area of Stor Jougdan in northern Jämtland, central Sweden. Peak-metamorphic assemblage of eclogite, garnet + omphacite + phengite + rutile + coesite? yields P–Tconditions of 2.8–4.0 GPa and 750–900 °C, constrained by conventional geothermobarometry and thermodynamic modelling in the NCKFMTASH system. The prograde metamorphic evolution of the eclogite is inferred from inclusions of zoisite and amphibole in garnet, which are stable at lower pressure, whereas the retrograde evolution is recorded by formation of diopsidic clinopyroxene + plagioclase symplectites after omphacite, growth of amphibole replacing these symplectites, and of titanite around rutile. In garnet pyroxenite the peak-metamorphic assemblage consists of garnet + orthopyroxene + clinopyroxene + olivine. P–T conditions of 2.3–3.8 GPa and 810–960 °C have been derived based on the conventional geothermobarometry and thermodynamic modelling in the CFMASH and CFMAS systems. Retrograde evolution has been recognized from replacement of pyroxene and garnet by amphibole. The results show that eclogite was metamorphosed during deep subduction of continental crust, most probably derived from the continental margin of Baltica, whereas the origin and tectonic setting of the garnet pyroxenite is ambiguous. The studied pyroxenite/peridotite of Baltican subcontinental affinity could have been metamorphosed as a part of the subducting plate and exhumed due to the downward extraction of a forearc lithospheric block.

    Keyword
    eclogite–garnet pyroxenite;subduction–exhumation;Swedish Caledonides;ultrahigh-pressure allochthons
    National Category
    Geology Other Earth and Related Environmental Sciences
    Research subject
    Earth Science with specialization in Mineral Chemistry, Petrology and Tectonics
    Identifiers
    urn:nbn:se:uu:diva-271063 (URN)10.1111/jmg.12173 (DOI)000369864800001 ()
    Funder
    The Crafoord FoundationThe Royal Swedish Academy of Sciences, 007Swedish Research Council, 2012-4441
    Available from: 2016-01-05 Created: 2016-01-05 Last updated: 2017-10-30Bibliographically approved
    3. Microdiamond on Åreskutan confirms regional UHP metamorphism in the Seve Nappe Complex of the Scandinavian Caledonides
    Open this publication in new window or tab >>Microdiamond on Åreskutan confirms regional UHP metamorphism in the Seve Nappe Complex of the Scandinavian Caledonides
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    2017 (English)In: Journal of Metamorphic Geology, ISSN 0263-4929, E-ISSN 1525-1314, Vol. 35, 541-564 p.Article in journal (Refereed) Published
    Abstract [en]

    Metamorphic diamond in crustal rocks provides important information on the deep subduction of continental crust. Here, we present a new occurrence of diamond within the Seve Nappe Complex (SNC) of the Scandinavian Caledonides, on angstrom reskutan in Jamtland County, Sweden. Microdiamond is found insitu as single and composite (diamond+carbonate) inclusions within garnet, in kyanite-bearing paragneisses. The rocks preserve the primary peak pressure assemblage of Ca,Mg-rich garnet+phengite+kyanite+rutile, with polycrystalline quartz surrounded by radial cracks indicating breakdown of coesite. Calculated P-T conditions for this stage are 830-840 degrees C and 4.1-4.2GPa, in the diamond stability field. The ultrahigh-pressure (UHP) assemblage has been variably overprinted under granulite facies conditions of 850-860 degrees C and 1.0-1.1GPa, leading to formation of Ca,Mg-poor garnet+biotite+plagioclase+K-feldspar+sillimanite+ilmenite+quartz. This overprint was the result of nearly isothermal decompression, which is corroborated by Ti-in-quartz thermometry. Chemical Th-U-Pb dating of monazite yields ages between 445 and 435Ma, which are interpreted to record post-UHP exhumation of the diamond-bearing rocks. The new discovery of microdiamond on angstrom reskutan, together with other evidence of ultrahigh-pressure metamorphism (UHPM) within gneisses, eclogites and peridotites elsewhere in the SNC, provide compelling arguments for regional (at least 200km along strike of the unit) UHPM of substantial parts of this far-travelled allochthon. The occurrence of UHPM in both rheologically weak (gneisses) and strong lithologies (eclogites, peridotites) speaks against the presence of large tectonic overpressure during metamorphism.

    National Category
    Geology
    Identifiers
    urn:nbn:se:uu:diva-332532 (URN)10.1111/jmg.12244 (DOI)000402647600004 ()
    Funder
    The Royal Swedish Academy of Sciences, GS2015-0006
    Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-11-07Bibliographically approved
    4. Middle Ordovician subduction of continental crust in the Scandinavian Caledonides - an example from Tjeliken, Seve Nappe Complex, Sweden
    Open this publication in new window or tab >>Middle Ordovician subduction of continental crust in the Scandinavian Caledonides - an example from Tjeliken, Seve Nappe Complex, Sweden
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    (English)In: Article in journal (Refereed) Submitted
    National Category
    Geology
    Identifiers
    urn:nbn:se:uu:diva-332528 (URN)
    Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-10-30
    5. UHP metamorphism recorded by phengite eclogite from the Caledonides of northern Sweden: P-T path and tectonic implications
    Open this publication in new window or tab >>UHP metamorphism recorded by phengite eclogite from the Caledonides of northern Sweden: P-T path and tectonic implications
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    (English)In: Article in journal (Refereed) Submitted
    National Category
    Geology
    Identifiers
    urn:nbn:se:uu:diva-332529 (URN)
    Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-10-30
    6. Ba- and Ti-enriched dark mica from the UHP metasediments of the Seve Nappe Complex, Swedish Caledonides.
    Open this publication in new window or tab >>Ba- and Ti-enriched dark mica from the UHP metasediments of the Seve Nappe Complex, Swedish Caledonides.
    2015 (English)In: Mineralogia, ISSN 1899-8291, E-ISSN 1899-8526, Vol. 46, 41-50 p.Article in journal (Refereed) Published
    National Category
    Geology
    Identifiers
    urn:nbn:se:uu:diva-332530 (URN)
    Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-10-30
    7. Lower Ordovician UHP metamorphism of the Baltoscandian margin recorded by the Seve Nappe Complex in southern Västerbotten, Scandinavian Caledonides
    Open this publication in new window or tab >>Lower Ordovician UHP metamorphism of the Baltoscandian margin recorded by the Seve Nappe Complex in southern Västerbotten, Scandinavian Caledonides
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Geology
    Identifiers
    urn:nbn:se:uu:diva-332531 (URN)
    Available from: 2017-10-30 Created: 2017-10-30 Last updated: 2017-10-30
  • Moldeus, Karolina
    et al.
    Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.;Visby Hosp, Dept Obstet & Gynecol, Visby, Sweden..
    Cheng, Yvonne W.
    Univ Calif Davis, Dept Surg, Davis, CA 95616 USA.;Calif Pacific Med Ctr, Dept Obstet & Gynecol, San Francisco, CA USA..
    Wikström, Anna-Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetric research. Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.
    Stephansson, Olof
    Karolinska Univ Hosp & Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden.;Karolinska Inst, Div Obstet & Gynecol, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Induction of labor versus expectant management of large-for-gestational-age infants in nulliparous women2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 7, e0180748Article in journal (Refereed)
    Abstract [en]

    Background There is no apparent consensus on obstetric management, i.e., induction of labor or expectant management of women with suspected large-for-gestational-age (LGA)-fetuses. Methods and findings To further examine the subject, a nationwide population-based cohort study from the Swedish Medical Birth Register in nulliparous non-diabetic women with singleton, vertex LGA (> 90 th centile) births, 1992-2013, was performed. Delivery of a live-born LGA infant induced at 38 completed weeks of gestation in non-preeclamptic pregnancies, was compared to those of expectant management, with delivery at 39, 40, 41, or 42 completed weeks of gestation and beyond, either by labor induction or via spontaneous labor. Primary outcome was mode of delivery. Secondary outcomes included obstetric anal sphincter injury, 5-minute Apgar< 7 and birth injury. Multivariable logistic regression analysis was performed to control for potential confounding. We found that among the 722 women induced at week 38, there was a significantly increased risk of cesarean delivery (aOR = 1.44 95% CI: 1.20-1.72), compared to those with expectant management (n = 44 081). There was no significant difference between the groups in regards to risk of instrumental vaginal delivery (aOR = 1.05, 95% CI: 0.85-1.30), obstetric anal sphincter injury (aOR = 0.81, 95% CI: 0.55-1.19), nor 5minute Apgar<7 (aOR = 1.06, 95% CI: 0.58-1.94) or birth injury (aOR = 0.82, 95% CI: 0.49- 1.38). Similar comparisons for induction of labor at 39, 40 or 41 weeks compared to expectant management with delivery at a later gestational age, showed increased rates of cesarean delivery for induced women. Conclusions In women with LGA infants, induction of labor at 38 weeks gestation is associated with increased risk of cesarean delivery compared to expectant management, with no difference in neonatal morbidity.

  • Public defence: 2017-12-08 13:15 Geijersalen (6-1023), Uppsala
    Berglund, Karl
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Literature, Sociology of Literature.
    Mordens marknad: Litteratursociologiska studier i det tidiga 2000-talets svenska kriminallitteratur2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation deals with Swedish crime fiction and its successes on the Swedish book market in the early 2000s. The genre’s expansion, marketing and literary content is mapped and analysed in three studies that together paint a thorough picture of this literary phenomena in Swedish book trade.

    In study no 1 the development of the genre in Sweden in the last 40 years is discussed from a quantitative perspective. With the base in bibliographies of Swedish crime fiction publication trends are analysed in several ways and concerning topics such as genre growth, gender balance, publishing houses, successful authorships, bestsellers and library lending. The results include: a significant genre expansion in the 2000s; a great dominance for the genre on the bestseller charts in the 2000s; and a shift in the author group, from male dominance to even gender balance.

    In study no 2 the marketing of the genre is examined through an analysis of book covers, titles and other elements in the concrete packaging of just over 150 Swedish crime fiction paperbacks. With book history as an important theoretical influence book covers and other peritextual elements are understood as a significant part of the marketing of the genre, but also – and wider – as of crucial importance for how genres themselves are established, withheld and re-negotiated in the interplay between different actors in the society of literature – publishers, authors, booksellers, readers.

    In study no 3 a quantitative content analysis of 116 Swedish crime novels published 1998–2015 is used to chart and discuss recurring themes and tropes within the genre. Focus is primarily directed towards what is understood as the most central parts of crime fiction: murderers and their motives; methods used in committing murder; victims of murder; and detectives and other protagonists. The results include: a distinct dominance of female protagonists; a partial realism, where depictions of everyday life in general is realistic while the murder plots are spectacular and sensational; and a dominance of normality, where main characters and innocent victims confirms normality, while killers and unsympathetic victims are depicted as deviants in stark contrast with normality.

    List of papers
    1. Deckarboomen under lupp: Statistiska perspektiv på svensk kriminallitteratur 1977–2010
    Open this publication in new window or tab >>Deckarboomen under lupp: Statistiska perspektiv på svensk kriminallitteratur 1977–2010
    2012 (Swedish)Book (Other academic)
    Alternative title[en]
    The Crime Boom Investigated : Statistical Perspectives on Swedish Crime Fiction, 1977–2010
    Abstract [en]

    This study examines the boom in Swedish crime fiction from a statistical perspective. Theoretical input and methods are derived from the fields of sociology of literature, book history, and bibliometrics. With a quantitative approach, all Swedish crime fiction published in 1977–2010 (just over 1,700 titles) are compiled to identify patterns over time. The main source for bibliographical information and delimitations is “Deckarkatalogen” (an annual bibliography published by the Swedish crime fiction magazine Jury).

    Main results: Nearly 2.5 times as many first editions of crime fiction were issued in Sweden in the first decade of the 2000s, compared to the 1980s. The increase was particularly vast in the years following the turn of the millennium. All kinds of publishers have contributed to this expansion, but two types stand out: major publishers and self-publishers. The share of crime fiction written by women increased in the same period of time from between 10 and 20 percent to just over 30 percent. Furthermore, the gender balance among the bestsellers of crime fiction in the 2000s is nearly even. Crime fiction has been extremely dominant on the bestseller charts in Sweden during the 2000s, and the genre outnumbers all other fiction taken together. A few major publishing groups are publishing a growing share of the crime fiction bestsellers. Mostly newer authors are bestsellers in the 2000s, and the time from debut to commercial success is shrinking.

    In the conclusion it is argued that crime fiction can be seen as the normal literature – a term coined by Franco Moretti – among bestsellers of fiction in Sweden during the first decade of the 2000s. The study gives insight into the interplay between authors, publishers, and the reading public, and helps us understand how genre, from a sociological point of view, operates on the literary market.

    Place, publisher, year, edition, pages
    Uppsala: Avdelningen för litteratursociologi, Uppsala universitet, 2012. 224 p. Edition: 1
    Series
    Skrifter utgivna av Avdelningen för litteratursociologi vid Litteraturvetenskapliga institutionen i Uppsala, ISSN 0349-1145 ; 64
    Keyword
    Swedish crime fiction, statistics, book market, publishing, sociology of literature, book history, bibliometrics
    National Category
    General Literature Studies
    Research subject
    Literature
    Identifiers
    urn:nbn:se:uu:diva-184976 (URN)978-91-88300-56-0 (ISBN)
    Projects
    Deckare som mål eller medel?
    Available from: 2012-11-15 Created: 2012-11-15 Last updated: 2017-11-23Bibliographically approved
    2. Mordförpackningar: Omslag, titlar och kringmaterial till svenska pocketdeckare 1998–2011
    Open this publication in new window or tab >>Mordförpackningar: Omslag, titlar och kringmaterial till svenska pocketdeckare 1998–2011
    2016 (Swedish)Book (Other academic)
    Abstract [en]

    This study examines how Swedish crime fiction has been packaged in the book trade in the early 2000s. The main material consists of 153 Swedish crime fiction paperbacks published in Sweden 1998–2011 and written by the most successful authors of crime fiction of that period. The term peritext, coined by Gérard Genette, is used to cover all aspects of books that affect the reader apart from the literary work itself. Five empirical chapters focus on five different aspects: 1) cover design; 2) titles and subtitles; 3) citations and blurbs; 4) acknowledgements; and 5) author presentations, extra material and advertising. It is shown that the packaging of crime fiction is crucial when it comes to genre formation and author branding. Among the results are how these “murder packages” have become increasingly elaborated over time, that male and female writers of crime fiction have been presented in distinctly different ways, and how the reliability and realism of a story often is emphasized in the peritext.

    Place, publisher, year, edition, pages
    Uppsala: Uppsala universitet, 2016. 283 p.
    Series
    Skrifter utgivna av Avdelningen för litteratursociologi vid Litteraturvetenskapliga institutionen i Uppsala, ISSN 0349-1145 ; 70
    Keyword
    Swedish crime fiction, book history, sociology of literature, publishing studies, book covers, book trade, pretext, Svenska deckare, bokhistoria, litteratursociologi, förlagsstudier, bokomslag, bokmarknad, paratext
    National Category
    General Literature Studies
    Research subject
    Literature
    Identifiers
    urn:nbn:se:uu:diva-289285 (URN)978-91-982819-1-0 (ISBN)
    Available from: 2016-04-29 Created: 2016-04-29 Last updated: 2017-11-23Bibliographically approved
    3. Död och dagishämtningar: en kvantitativ analys av det tidiga 2000-talets svenska kriminallitteratur
    Open this publication in new window or tab >>Död och dagishämtningar: en kvantitativ analys av det tidiga 2000-talets svenska kriminallitteratur
    2017 (Swedish)Book (Other academic)
    Abstract [en]

    This study investigates contemporary Swedish crime fiction through a quantitative content analysis of 116 Swedish crime fiction novels published 1998–2015 and written by the most successful authors in the genre. The study discusses killers, murder motives, victims, murder methods, and detectives and other protagonists, with the aim of identifying social patterns and recurring themes.

    In general, these novels are dominated by female protagonists and put much emphasis on portrayals of the main characters in their struggle to combine work and family life. This simultaneous shift to a female perspective and a focus on everyday life stands out in comparisons to earlier Swedish crime fiction. The novels are furthermore permeated by a partial realism, where depictions of everyday life, settings and contemporary details are realistic and concrete, while depictions of killers, murder motives, murder methods and victims most often are imaginative, spectacular and sensational, and thus in most cases show few similarities with actual crimes in contemporary Sweden. Also, the selection is characterised by a dominance of normality, where main characters and innocent victims affirm “normality” (they are most often middle class, white, heterosexual Swedes without immigrant background), whereas killers and unsympathetic victims are depicted as deviants in stark contrast to normality.

    The content often seems to be chosen by how well it works in relation to plot lines and genre requirements. Therefore, it is argued that both contextualising and functionalistic perspectives need to be taken into account when analysing depictions of society in contemporary crime fiction. With such a dual-vision approach, the ostensible realistic social criticism in the genre to a high extent appears to be a story about the genre.

    Place, publisher, year, edition, pages
    Uppsala: Avd. för litteratursociologi, Uppsala universitet, 2017. 199 p. Edition: 1
    Series
    Skrifter utgivna av Avdelningen för litteratursociologi vid Litteraturvetenskapliga institutionen i Uppsala, ISSN 0349-1145 ; 73
    Keyword
    Swedish crime fiction, quantitative content analysis, sociology of literature, popular fiction, genre functions, social criticism in literature.
    National Category
    General Literature Studies
    Research subject
    Literature
    Identifiers
    urn:nbn:se:uu:diva-331569 (URN)978-91-982819-3-4 (ISBN)
    Available from: 2017-10-15 Created: 2017-10-15 Last updated: 2017-11-23Bibliographically approved
  • Public defence: 2017-12-08 09:15 Rudbecksalen, Uppsala
    Baskaran, Sathishkumar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Department of IGP, Uppsala University.
    New Molecular Approaches to Glioblastoma Therapy2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than 50 years of age. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. The median life expectancy of patients is only between 12 to 15 months after receiving current treatment regimes. Hence, identification of new therapeutic compounds and gene targets are highly warranted. This thesis describes four interlinked studies to attain this goal. In study 1, we explored drug combination effects in a material of 41 patient-derived GBM cell (GC) cultures. Synergies between three compounds, pterostilbene, gefitinib, and sertraline, resulted in effective killing of GC and can be predicted by biomarkers. In study 2, we performed a large-scale screening of FDA approved compounds (n=1544) in a larger panel of GCs (n=106). By combining the large-scale drug response data with GCs genomics data, we built a novel computational model to predict the sensitivity of each compound for a given GC. A notable finding was that GCs respond very differently to proteasome inhibitors in both in-vitro and in-vivo. In study 3, we explored new gene targets by RNAi (n=1112) in a panel of GC cells. We found that loss of transcription factor ZBTB16/PLZF inhibits GC cell viability, proliferation, migration, and invasion. These effects were due to downregulation of c-MYC and Cyclin B1 after the treatment. In study 4, we tested the genomic stability of three GCs upon multiple passaging. Using molecular and mathematical analyses, we showed that the GCs undergo both systematic adaptations and sequential clonal takeovers. Such changes tend to affect a broad spectrum of pathways. Therefore, a systematic analysis of cell culture stability will be essential to make use of primary cells for translational oncology.

    Taken together, these studies deepen our knowledge of the weak points of GBM and provide several targets and biomarkers for further investigation. The work in this thesis can potentially facilitate the development of targeted therapies and result in more accurate tools for patient diagnostics and stratification. 

    List of papers
    1. Case-specific potentiation of glioblastoma drugs by pterostilbene
    Open this publication in new window or tab >>Case-specific potentiation of glioblastoma drugs by pterostilbene
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    2016 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 7, no 45, 73200-73215 p.Article in journal (Refereed) Published
    National Category
    Cancer and Oncology Medical Genetics
    Identifiers
    urn:nbn:se:uu:diva-309806 (URN)10.18632/oncotarget.12298 (DOI)000387452100060 ()
    Funder
    Swedish Research CouncilSwedish Cancer SocietySwedish Childhood Cancer Foundation
    Available from: 2016-09-28 Created: 2016-12-07 Last updated: 2017-10-22Bibliographically approved
    2. Targeting tumor heterogeneity: multi-omic modeling of glioblastoma drug response using an open-access library of patient-derived cells
    Open this publication in new window or tab >>Targeting tumor heterogeneity: multi-omic modeling of glioblastoma drug response using an open-access library of patient-derived cells
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    (English)Manuscript (preprint) (Other academic)
    Keyword
    GBM, Proteasome inhibitors, Precision medicine, Bortezomib, drug predictions
    National Category
    Cancer and Oncology Cell and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
    Research subject
    Biology with specialization in Molecular Biology; Oncology; Bioinformatics; Medical Science
    Identifiers
    urn:nbn:se:uu:diva-329756 (URN)
    Available from: 2017-09-20 Created: 2017-09-20 Last updated: 2017-10-30
    3. Loss of transcription factor ZBTB16 induces cell death in patient-derived GBM cell lines
    Open this publication in new window or tab >>Loss of transcription factor ZBTB16 induces cell death in patient-derived GBM cell lines