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  • Lindgren, Karin Elvine
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Yaldir, Fatma Gulen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Hreinsson, Julius
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden;Karolinska Univ Hosp, Unit Reprod Med, SE-14186 Stockholm, Sweden.
    Holte, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology. Carl von Linne Clin, SE-75183 Uppsala, Sweden.
    Kårehed, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
    Sundström Poromaa, Inger
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.
    Kaihola, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Åkerud, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Differences in secretome in culture media when comparing blastocysts and arrested embryos using multiplex proximity assay2018In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 3, p. 143-152Article in journal (Refereed)
    Abstract [en]

    Objectives: The aim of this study was to assess different patterns of the human embryo secretome analysed as protein levels in culture media. Furthermore, analyses to correlate protein levels with quality and timing to development of human embryos were performed.

    Material and methods: Human day-2 cryopreserved embryos were cultured for four days in an EmbryoScope((R)) with a time-lapse camera, and embryo quality was evaluated retrospectively. After culture, the media were collected and relative levels of secreted proteins were analysed using Proseek Multiplex Assays. Protein levels were evaluated in relation to timing to development and the ability to form a blastocyst.

    Results: Specific patterns of timing of development of blastocysts were found, where a difference in time to start of cavitation was found between high- and low-quality blastocysts. There appeared to be a correlation between specific protein patterns and successful formation of morulae and blastocysts. Embryos developing into blastocysts had higher levels of EMMPRIN than arrested embryos, and levels of caspase-3 were lower in high- versus low-quality blastocysts. Also, higher levels of VEGF-A, IL-6, and EMMPRIN correlated with shorter times to morula formation.

    Conclusions: The secretome and timing to development differ in embryos forming blastocysts and those that become arrested, and in high- versus low-quality blastocysts. The levels of certain proteins also correlate to specific times to development.

  • Zare, Reza
    et al.
    Vestre Viken HF Baerum Hosp, Dept Urol, Oslo, Norway.
    Grabe, Magnus
    Lund Univ, Skane Univ Hosp, Dept Urol, Malmo, Sweden.
    Hermann, Gregers G.
    Univ Copenhagen, Herlev & Gentofte Hosp, Dept Urol, Copenhagen, Denmark.
    Malmström, Per-Uno
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Can routine outpatient follow-up of patients with bladder cancer be improved?: A multicenter prospective observational assessment of blue light flexible cystoscopy and fulguration2018In: Research and Reports in Urology, ISSN 2253-2447, E-ISSN 1179-1551, Vol. 10, p. 151-157Article in journal (Refereed)
    Abstract [en]

    Background: The aim of this prospective cohort study was to determine the feasibility of incorporating blue light flexible cystoscopy (BLFC) and biopsy/fulguration into routine outpatient follow-up of non-muscle invasive bladder cancer patients.

    Methods: The study included patients with non-muscle-invasive bladder cancer (NMIBC) who were scheduled for routine follow-up. Hexaminolevulinate was instilled in the outpatient department, and the bladder was examined under white light and then with BLFC. Biopsies were taken from all suspicious lesions. Small tumors and suspicious lesions were fulgurated on site; patients with larger lesions were referred to the operating room for resection.

    Results: The study included 69 patients, with a mean age of 70 years (range 33 -89 years) and a mean duration since NMIBC diagnosis of 8 years. Most patients had high-grade cancer at initial diagnosis (52/69) and were at high risk of recurrence (48/69). Two patients per hour could be assessed using outpatient BLFC. Preparation and instillation of hexaminolevulinate took less than 10 minutes per patient, and patients had an additional waiting time of 45 60 minutes following instillation, while the hexaminolevulinate solution was retained in the bladder before examination. Eleven patients had histologically confirmed tumors that were identified using both white light flexible cystoscopy and BLFC. An additional three patients had tumors that were identified by BLFC only: two with Ta tumors and one with carcinoma in situ. Of the 14 patients with confirmed tumors, 11 could be managed on site with fulguration, whereas three were referred to the operating room. No adverse events attributable to BLFC were reported.

    Conclusion: Routine outpatient management of patients with NMIBC using BLFC and onsite biopsy/fulguration is feasible, despite the additional time required for hexaminolevulinate instillation, and appears to allow early detection of recurrent lesions, which can be fulgurated without the need for hospitalization.

  • Panda, Sunita
    et al.
    Trinity Coll Dublin, Sch Nursing & Midwifery, 2 Clare St, Dublin D02 CK80, Ireland.
    Daly, Deirdre
    Trinity Coll Dublin, Sch Nursing & Midwifery, 24 DOlier St, Dublin D02 T283, Ireland.
    Begley, Cecily
    Trinity Coll Dublin, Sch Nursing & Midwifery, 24 DOlier St, Dublin D02 T283, Ireland;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Karlstrom, Annika
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Larsson, Birgitta
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Back, Lena
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Hildingsson, Ingegerd
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research. Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Factors influencing decision-making for caesarean section in Sweden - a qualitative study2018In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 18, article id 377Article in journal (Refereed)
    Abstract [en]

    Background: Rising rates of caesarean section (CS) are a concern in many countries, yet Sweden has managed to maintain low CS rates. Exploring the multifactorial and complex reasons behind the rising trend in CS has become an important goal for health professionals. The aim of the study was to explore Swedish obstetricians' and midwives' perceptions of the factors influencing decision-making for CS in nulliparous women in Sweden. Methods: A qualitative design was chosen to gain in-depth understanding of the factors influencing the decision-making process for CS. Purposive sampling was used to select the participants. Four audio-recorded focus group interviews (FGIs), using an interview guide with open ended questions, were conducted with eleven midwives and five obstetricians from two selected Swedish maternity hospitals after obtaining written consent from each participant. Data were managed using NVivo (c) and thematically analysed. Ethical approval was granted by Trinity College Dublin. Results: The thematic analysis resulted in three main themes; 'Belief in normal birth - a cultural perspective'; 'Clarity and consistency - a system perspective' and 'Obstetrician makes the final decision, but ...', and each theme contained a number of subthemes. However, 'Belief in normal birth' emerged as the core central theme, overarching the other two themes. Conclusion: Findings suggest that believing that normal birth offers women and babies the best possible outcome contributes to having and maintaining a low CS rate. Both midwives and obstetricians agreed that having a shared belief (in normal birth), a common goal (of achieving normal birth) and providing mainly midwife-led care within a 'team approach' helped them achieve their goal and keep their CS rate low.

  • Ekstrand Ragnar, Maria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
    Grandahl, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
    Stern, Jenny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Sophiahemmet Univ, Dept Hlth Promoting Sci, Stockholm, Sweden.
    Mattebo, Magdalena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research. Malardalen Univ, Sch Hlth Care & Social Welf, Vasteras, Sweden.
    Important but far away: adolescents' beliefs, awareness and experiences of fertility and preconception health2018In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 23, no 4, p. 265-273Article in journal (Refereed)
    Abstract [en]

    Objectives: The aim was to explore adolescents' beliefs and awareness regarding fertility and preconception health, as well as their views and experiences of information about fertility and preconception health directed at their age group.

    Methods: We performed seven semi-structured focus group interviews among upper secondary school students (n = 47) aged 16-18 years in two Swedish counties. Data were analysed by qualitative content analysis.

    Results: One theme ('important but far away') and five categories ('starting a family far down on the list'; 'high awareness but patchy knowledge of fertility and preconception health'; 'gender roles influence beliefs about fertility and preconception health'; 'wish to preserve fertility and preconception health in order to keep the door to procreation open'; 'no panacea - early and continuous education about fertility and preconception health') emerged from the interviews. Participants recognised the importance of preconception health and were highly aware of the overall importance of a healthy lifestyle. Their knowledge, however, was patchy and they had difficulties relating to fertility and preconception health on a personal and behavioural level. Participants wanted more information but had heterogeneous beliefs about when, where and how this information should be given.

    Conclusion: The adolescents wanted information on fertility and preconception health to be delivered repeatedly as well as through different sources.

  • Choudhury, Sneha
    et al.
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany;Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 36a, D-14195 Berlin, Germany.
    Kiendl, Benjamin
    Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.
    Ren, Jian
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany;Free Univ Berlin, Dept Phys, Arnimallee 14, D-14195 Berlin, Germany.
    Gao, Fang
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany;Max Planck Inst Mikrostrukturphys, Weinberg 2, D-06120 Halle, Germany.
    Knittel, Peter
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany.
    Nebel, Christoph
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany.
    Venerosy, Amelie
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Girard, Hugues
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Arnault, Jean-Charles
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Krueger, Anke
    Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.
    Larsson, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Petit, Tristan
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Combining nanostructuration with boron doping to alter sub band gap acceptor states in diamond materials2018In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 6, no 34, p. 16645-16654Article in journal (Refereed)
    Abstract [en]

    Diamond is a promising metal-free photocatalyst for nitrogen and carbon dioxide reduction in aqueous environment owing to the possibility of emitting highly reducing solvated electrons. However, the wide band gap of diamond necessitates the use of deep UV to trigger a photochemical reaction. Boron doping introduces acceptor levels within the band gap of diamonds, which may facilitate visible-light absorption through defect-based transitions. In this work, unoccupied electronic states from different boron-doped diamond materials, including single crystal, polycrystalline film, diamond foam, and nanodiamonds were probed by soft X-ray absorption spectroscopy at the carbon K edge. Supported by density functional theory calculations, we demonstrate that boron close to the surfaces of diamond crystallites induce acceptor levels in the band gap, which are dependent on the diamond morphology. Combining boron-doping with morphology engineering, this work thus demonstrates that electron acceptor states within the diamond band gap can be controlled.

  • Braun, Andreas P.
    et al.
    Univ Oxford, Math Inst, Woodstock Rd, Oxford OX2 6GG, England.
    Del Zotto, Michele
    SUNY Stony Brook, Simons Ctr Geometry & Phys, Stony Brook, NY 11794 USA.
    Halverson, James
    Northeastern Univ, Dept Phys, Boston, MA 02115 USA.
    Larfors, Magdalena
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Morrison, David R.
    Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA.
    Schafer-Nameki, Sakura
    Univ Oxford, Math Inst, Woodstock Rd, Oxford OX2 6GG, England.
    Infinitely many M2-instanton corrections to M-theory on G(2)-manifolds2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 9, article id 077Article in journal (Refereed)
    Abstract [en]

    We consider the non-perturbative superpotential for a class of four-dimensional N = 1 vacua obtained from M-theory on seven-manifolds with holonomy G(2). The class of G(2)-holonomy manifolds we consider are so-called twisted connected sum (TCS) constructions, which have the topology of a K3-fibration over S-3. We show that the non-perturbative superpotential of M-theory on a class of TCS geometries receives infinitely many inequivalent M2-instanton contributions from infinitely many three-spheres, which we conjecture are supersymmetric (and thus associative) cycles. The rationale for our construction is provided by the duality chain of [1], which relates M-theory on TCS G(2) manifolds to E-8 x E-8 heterotic backgrounds on the Schoen Calabi-Yau threefold, as well as to F-theory on a K3-fibered Calabi-Yau fourfold. The latter are known to have an infinite number of instanton corrections to the superpotential and it is these contributions that we trace through the duality chain back to the G(2)-compactification.

  • Chiavassa, A.
    et al.
    Univ Cote dAzur, Observ Cote dAzur, CNRS, Lagrange, CS 34229, Nice, France.
    Freytag, Bernd
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Schultheis, M.
    Univ Cote dAzur, Observ Cote dAzur, CNRS, Lagrange, CS 34229, Nice, France.
    Heading Gaia to measure atmospheric dynamics in AGB stars2018In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 617, article id L1Article in journal (Refereed)
    Abstract [en]

    Context. Asymptotic giant branch (AGB) stars are characterised by complex stellar surface dynamics that affect the measurements and amplify the uncertainties on stellar parameters. The uncertainties in observed absolute magnitudes have been found to originate mainly from uncertainties in the parallaxes. The resulting motion of the stellar photocentre could have adverse effects on the parallax determination with Gaia. Aims. We explore the impact of the convection-related surface structure in AGBs on the photocentric variability. We quantify these effects to characterise the observed parallax errors and estimate fundamental stellar parameters and dynamical properties. Methods. We use three-dimensional (3D) radiative hydrodynamics simulations of convection with CO5BOLD and the post-processing radiative transfer code OPTIM3D to compute intensity maps in the Gaia G band [325-1030 nm]. From those maps, we calculate the intensity-weighted mean of all emitting points tiling the visible stellar surface (i.e. the photocentre) and evaluate its motion as a function of time. We extract the parallax error from Gaia data-release 2 (DR2) for a sample of semi-regular variables in the solar neighbourhood and compare it to the synthetic predictions of photocentre displacements. Results. AGB stars show a complex surface morphology characterised by the presence of few large-scale long-lived convective cells accompanied by short-lived and small-scale structures. As a consequence, the position of the photocentre displays temporal excursions between 0.077 and 0.198 AU (approximate to 5 to approximate to 11% of the corresponding stellar radius), depending on the simulation considered. We show that the convection-related variability accounts for a substantial part of the Gaia DR2 parallax error of our sample of semi-regular variables. Finally, we present evidence for a correlation between the mean photocentre displacement and the stellar fundamental parameters: surface gravity and pulsation. We suggest that parallax variations could be exploited quantitatively using appropriate radiation-hydrodynamics (RHD) simulations corresponding to the observed star.

  • Ivanov, Sergey
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics. Karpov Inst Phys Chem, Ctr Mat Sci, Vorontsovo Pole 10, Moscow Russia.
    Andersson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Cedervall, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Lewin, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Sahlberg, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Bazuev, G. V.
    Russian Acad Sci, Inst Solid State Chem, Ural Branch, Ekaterinburg 620990, Russia.
    Nordblad, Per
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Mathieu, Roland
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Temperature-dependent structural and magnetic properties of R2MMnO6 double perovskites (R=Dy, Gd; M=Ni, Co)2018In: Journal of materials science. Materials in electronics, ISSN 0957-4522, E-ISSN 1573-482X, Vol. 29, no 21, p. 18581-18592Article in journal (Refereed)
    Abstract [en]

    The structural and magnetic properties of the Dy2CoMnO6, Dy2NiMnO6 and Gd2CoMnO6 double perovskites are investigated using X-ray powder diffraction and squid magnetometry. The materials adopt an orthorhombic structure (space ground Pnma) with disordered Co(Ni)/Mn cations, and exhibit ferrimagnetic transitions near T(C)85, 95, and 115K respectively. T-C was found to monotonously depend on the orthorhombic distortion (a-c)/(a+c) of the compounds. The crystal structure of the compounds was investigated as a function of temperature (16-1100K range), evidencing changes in the BO6 octahedron near T-C. The magnetic entropy changes are estimated for comparison of the magnetocaloric properties to those from literature.

  • Ardhe, Jonna Elisabeth
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law, Department of Law.
    Icke-ekonomiska intressen och värden i den skadeståndsrättsliga kontexten: med inriktning mot affektionsintressen och affektionsvärden2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Mei, Xueshuang
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery. Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Beijing, Peoples R China.
    Atturo, Francesca
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Wadin, Karin
    Uppsala Univ Hosp, Dept Diagnost Radiol, Uppsala, Sweden.
    Larsson, Sune
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Agrawal, Sumit
    Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.
    Ladak, Hanif M.
    Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada;Western Univ, Dept Med Biophys, London, ON, Canada;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.
    Li, Hao
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Rask-Andersen, Helge
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
    Human inner ear blood supply revisited: the Uppsala collection of temporal bone - an international resource of education and collaboration2018In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, no 3, p. 131-142Article in journal (Refereed)
    Abstract [en]

    Background: The Uppsala collection of human temporal bones and molds is a unique resource for education and international research collaboration. Micro-computerized tomography (micro-CT) and synchrotron imaging are used to investigate the complex anatomy of the inner ear. Impaired microcirculation is etiologically linked to various inner ear disorders, and recent developments in inner ear surgery promote examination of the vascular system. Here, for the first time, we present three-dimensional (3D) data from investigations of the major vascular pathways and corresponding bone channels.

    Methods: We used the archival Uppsala collection of temporal bones and molds consisting of 324 inner ear casts and 113 macerated temporal bones. Micro-CT was used to investigate vascular bone channels, and 26 fresh human temporal bones underwent synchrotron radiation phase contrast imaging (SR-PCI). Data were processed by volume-rendering software to create 3D reconstructions allowing orthogonal sectioning, cropping, and soft tissue analyses.

    Results: Micro-CT with 3D rendering was superior in reproducing the anatomy of the vascular bone channels, while SR-PCI replicated soft tissues. Arterial bone channels were traced from scala vestibuli (SV) arterioles to the fundus, cochlea, and vestibular apparatus. Drainage routes along the aqueducts were examined.

    Conclusion: Human inner ear vessels are difficult to study due to the adjoining hard bone. Micro-CT and SR-PCI with 3D reconstructions revealed large portions of the micro-vascular system in un-decalcified specimens. The results increase our understanding of the organization of the vascular system in humans and how altered microcirculation may relate to inner ear disorders. The findings may also have surgical implications.

  • Sandelowsky, Hanna
    et al.
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
    Krakau, Ingvar
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Karolinska Inst, Dept Med, Div Clin Epidemiol, Stockholm, Sweden.
    Modin, Sonja
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Johansson, Sven-Erik
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
    Nager, Anna
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden.
    Effectiveness of traditional lectures and case methods in Swedish general practitioners' continuing medical education about COPD: a cluster randomised controlled trial2018In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 8, article id e021982Article in journal (Refereed)
    Abstract [en]

    Objectives: To study the effects of continuing medical education (CME) about chronic obstructive pulmonary disease (COPD) for general practitioners (GPs) by comparing two commonly used CME methods with each other and no CME (reference group).

    Design: A pragmatic cluster randomised controlled trial with primary healthcare centres (PHCCs) as units of randomisation.

    Setting, participants and interventions: 24 PHCCs in Stockholm County, Sweden, were randomised into two CME intervention arms: case method learning (CM) (n=12) and traditional lectures (TL) (n=12). A reference group without CME (n=11) was recruited separately. GPs (n=255) participated in the study arm to which their PHCC was allocated: CM, n=87; TL, n=93; and reference, n=75. Two 2-hour CME seminars were given in a period of 3 months.

    Primary outcome measures: Changes in scores between baseline and 12 months on a 13-item questionnaire about evidence-based COPD management (0-2 points/question, maximum total score 26 points).

    Results: 133 (52%) GPs completed the questionnaire both at baseline and 12 months. Both CM and TL resulted in small yet significantly higher total scores at 12 months than at baseline (CM, 10.34 vs 11.44; TL, 10.21 vs 10.91; p<0.05); there were few significant differences between these CME methods. At both baseline and 12 months, all three groups' scores were generally high on questions about smoking cessation support and low on those that measured spirometry interpretation skills, interprofessional care and management of multimorbidity.

    Conclusions: Neither short CM nor short TL CME sessions substantially improve GPs' skills in managing COPD. It is justified to challenge the use of these common CME methods as a strategy for improving GPs' level of knowledge about management of COPD and other complex chronic diseases characterised by multimorbidity. Trial registration number NCT02213809

  • Tistad, Malin
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden;Umea Univ, Dept Rehabil & Social Med, Physiotherapy, Umea, Sweden.
    Flink, Maria
    Karolinska Univ Hosp, Funct Area Social Work Hlth, Stockholm, Sweden;Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden.
    Ytterberg, Charlotte
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Physiotherapy, Huddinge, Sweden;Karolinska Univ Hosp, Funct Area Occupat Therapy & Physiotherapy, Stockholm, Sweden.
    Eriksson, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rehabilitation Medicine. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden.
    Guidetti, Susanne
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden.
    Tham, Kerstin
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Malmo Univ, Fac Hlth & Soc, Malmo, Sweden.
    von Koch, Lena
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Karolinska Univ Hosp, Theme Neuro, Stockholm, Sweden.
    Resource use of healthcare services 1 year after stroke: a secondary analysis of a cluster-randomised controlled trial of a client-centred activities of daily living intervention2018In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 8, article id e022222Article in journal (Refereed)
    Abstract [en]

    Objective: The objective of the study was to compare the total use of healthcare services in the course of the first year after a stroke between participants who, after the acute care, had received occupational therapy as a client-centred activities of daily living (ADL) intervention (CADL) and participants who had received usual ADL intervention (UADL).

    Design: A secondary analysis of a multicentre cluster-randomised controlled trial (RCT).

    Setting: Primary and secondary care in Sweden.

    Participants: Participants were included if they: (1) had received CADL or UADL in the RCT, either as inpatients in geriatric rehabilitation units or in their own homes, and (2) data could be retrieved about their use of healthcare services provided by the county council from computerised registers.

    Interventions: CADL or UADL.

    Outcome measures: Inpatient and outpatient healthcare in the course of the first year after stroke.

    Results: Participants from 7 of the 16 units included in the RCT met the criteria. Participants in the CADL group (n=26) who received geriatric inpatient rehabilitation had a shorter length of hospital stay (p=0.03) than participants in the UADL group (n=46), and the CADL group with home rehabilitation (n=13) had fewer outpatient contacts (p=0.01) compared with the UADL group (n=25). Multiple regression analyses showed that in four of the models, a higher age was associated with a lower use of healthcare services. The use of healthcare services was also associated (some of the models) with dependence in ADL, stroke severity and type of rehabilitation received, CADL or UADL.

    Conclusions: The provision of client-centred occupational therapy after stroke did not appear to increase the use of healthcare services during the first year after stroke. Trial registration number NCT01417585.

  • Wright, Alison E.
    et al.
    Univ Sheffield, Dept Anim & Plant Sci, Sheffield, S Yorkshire, England.
    Fumagalli, Matteo
    Imperial Coll London, Dept Life Sci, Silwood Pk Campus, London, England.
    Cooney, Christopher R.
    Univ Sheffield, Dept Anim & Plant Sci, Sheffield, S Yorkshire, England.
    Bloch, Natasha, I
    UCL, Dept Genet Evolut & Environm, London, England.
    Vieira, Filipe G.
    Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, Copenhagen, Denmark.
    Buechel, Severine D.
    Stockholm Univ, Dept Zool, Stockholm, Sweden.
    Kolm, Niclas
    Stockholm Univ, Dept Zool, Stockholm, Sweden.
    Mank, Judith E.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. UCL, Dept Genet Evolut & Environm, London, England.
    Male-biased gene expression resolves sexual conflict through the evolution of sex-specific genetic architecture2018In: EVOLUTION LETTERS, ISSN 2056-3744, Vol. 2, no 2, p. 52-61Article in journal (Refereed)
    Abstract [en]

    Many genes are subject to contradictory selection pressures in males and females, and balancing selection resulting from sexual conflict has the potential to substantially increase standing genetic diversity in populations and thereby act as an important force in adaptation. However, the underlying causes of sexual conflict, and the potential for resolution, remains hotly debated. Using transcriptome-resequencing data from male and female guppies, we use a novel approach, combining patterns of genetic diversity and intersexual divergence in allele frequency, to distinguish the different scenarios that give rise to sexual conflict, and how this conflict may be resolved through regulatory evolution. We show that reproductive fitness is the main source of sexual conflict, and this is resolved via the evolution of male-biased expression. Furthermore, resolution of sexual conflict produces significant differences in genetic architecture between males and females, which in turn lead to specific alleles influencing sex-specific viability. Together, our findings suggest an important role for sexual conflict in shaping broad patterns of genome diversity, and show that regulatory evolution is a rapid and efficient route to the resolution of conflict.

  • Fu, Zhirong
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Thorpe, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Akula, Srinivas
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Chahal, Gurdeep
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Hellman, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability2018In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, article id 2387Article in journal (Refereed)
    Abstract [en]

    Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE), proteinase 3 (hPR-3), and neutrophil serine protease 4 (hNSP-4). Here we present the extended cleavage specificity of two of the most potent and most abundant of these enzymes, hNE and hPR-3. Their extended specificities were determined by phage display and by the analysis of a panel of chromogenic and recombinant substrates. hNE is an elastase with a relatively broad specificity showing a preference for regions containing several aliphatic amino acids. The protease shows self-cleaving activity, which results in the loss of activity during storage even at +4 degrees C. Here we also present the extended cleavage specificity of hPR-3. Compared with hNE, it shows considerably lower proteolytic activity. However, it is very stable, shows no self-cleaving activity and is actually more active in the presence of SDS, possibly by enhancing the accessibility of the target substrate. This enables specific analysis of hPR-3 activity even in the presence of all the other neutrophil enzymes with addition of 1% SDS. Neutrophils are the most abundant white blood cell in humans and one of the key players in our innate immune defense. The neutrophil serine proteases are very important for the function of the neutrophils and therefore also interesting from an evolutionary perspective. In order to study the origin and functional conservation of these neutrophil proteases we have identified and cloned an amphibian ortholog, Xenopus PR-3 (xPR-3). This enzyme was found to have a specificity very similar to hPR-3 but did not show the high stability in the presence of SDS. The presence of an elastase in Xenopus closely related to hPR-3 indicates a relatively early appearance of these enzymes during vertebrate evolution.

  • Lissbrant, Ingela Franck
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.
    Ventimiglia, Eugenio
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology. Osped San Raffaele, IRCCS, URI, Div Expt Oncol, Unit Urol, Milan, Italy.
    Robinson, David
    Ryhov Cty Hosp, Dept Urol, Jönköping, Sweden.
    Törnblom, Magnus
    Visby Cty Hosp, Dept Surg, Visby, Sweden.
    Hjalm-Eriksson, Marie
    Capio St Gorans Hosp, Dept Surg, Stockholm, Sweden; Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
    Lambe, Mats
    Uppsala Univ Hosp, Reg Canc Ctr, Uppsala, Sweden.
    Folkvaljon, Yasin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Nationwide population-based study on the use of novel antiandrogens in men with prostate cancer in Sweden2018In: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 52, no 2, p. 143-150Article in journal (Refereed)
    Abstract [en]

    Objectives: The aim of this study was to examine the use of abiraterone and enzalutamide, two oral novel antiandrogens (NOVAs), in men with prostate cancer (PCa) in Sweden.

    Materials and methods: This cross-sectional study investigated filled prescriptions for NOVAs recorded in the Swedish Prescribed Drug Register between July 2015 and April 2016. Associations between age, comorbidity, educational level, marital status and county of residence and filled prescriptions were analyzed in the National Prostate Cancer Register (NPCR) and other health population-based registers, using multivariable logistic regression.

    Results: Of 91,209 men, 1650 (2%) had at least one prescription filled for NOVAs, of whom 1350 (82%) had high-risk or metastatic PCa at diagnosis.. Of 1914 men with M1 disease and a high probability of castration-resistant prostate cancer (CRPC), 22% had a prescription for NOVAs at a median 3 years after the date of diagnosis. At multivariable logistic regression analysis,, the likelihood of NOVA use was lower in older men [age >80 vs <70 years: odds ratio (OR) 0.23, 95% confidence interval (CI) 0.15–0.35] and in men with lower educational level (high vs low education: OR 1.64, 95% CI 1.23–2.20). There was up to a five-fold difference in the use of NOVAs between county councils.

    Conclusions: Less than one-third of potentially eligible men with CRPC received NOVAs in 2015–2016. There were large differences in use according to age and region of residence, indicating that efforts are needed to improve equal access to novel cancer drugs.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of jet fragmentation in 5.02 TeV proton-lead and proton-proton collisions with the ATLAS detector2018In: Nuclear Physics A, ISSN 0375-9474, E-ISSN 1873-1554, Vol. 978, p. 65-106Article in journal (Refereed)
    Abstract [en]

    A measurement of the fragmentation functions of jets into charged particles in p Pb collisions and pp collisions is presented. The analysis utilizes 28 nb(-1) of p Pb data and 26 pb(-1) of pp data, both at root(TN)-T-s= 5.02 TeV, collected in 2013 and 2015, respectively, with the ATLAS detector at the LHC. The measurement is reported in the centre-of-mass frame of the nucleon-nucleon system for jets in the rapidity range vertical bar y*vertical bar <1.6 and with transverse momentum 45 < p(T) < 260 GeV. Results are presented both as a function of the charged-particle transverse momentum and as a function of the longitudinal momentum fraction of the particle with respect to the jet. The pp fragmentation functions are compared with results from Monte Carlo event generators and two theoretical models. The ratios of the p +Pb to pp fragmentation functions are found to be consistent with unity.

  • Flygt, Frida
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Keil, Susanne
    Elevers delaktighet vid skrivande: En intervju och observationsstudie om hur elevers delaktighet bereds i skrivundervisningen i skolår 3, satt i en specialpedagogisk kontext2018Independent thesis Advanced level (professional degree), 60 credits / 90 HE creditsStudent thesis
  • Chiavaroli, Valentina
    et al.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Hopkins, Sarah A.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Derraik, Jose G. B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, A Better Start Natl Sci Challenge, Auckland, New Zealand.
    Biggs, Janene B.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Rodrigues, Raquel O.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Brennan, Christine H.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Seneviratne, Sumudu N.
    Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Colombo, Dept Paediat, Fac Med, Colombo, Sri Lanka.
    Higgins, Chelsea
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Baldi, James C.
    Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand.
    McCowan, Lesley M. E.
    Univ Auckland, Dept Obstet & Gynaecol, Fac Med & Hlth Sci, Auckland, New Zealand.
    Cutfield, Wayne S.
    Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, A Better Start Natl Sci Challenge, Auckland, New Zealand.
    Hofman, Paul L.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Exercise in pregnancy: 1-year and 7-year follow-ups of mothers and offspring after a randomized controlled trial2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 12915Article in journal (Refereed)
    Abstract [en]

    There are limited data on long-term outcomes of mothers or their offspring following exercise interventions during pregnancy. We assessed long-term effects of an exercise intervention (home-based stationary cycling) between 20-36 weeks of gestation on anthropometry and body composition in mothers and offspring after 1 and 7 years. 84 women were randomised to intervention or usual activity, with follow-up data available for 61 mother-child pairs (38 exercisers) at 1 year and 57 (33 exercisers) at 7 years. At 1 year, there were no observed differences in measured outcomes between mothers and offspring in the two groups. At the 7-year follow-up, mothers were mostly similar, except that exercisers had lower systolic blood pressure (-6.2 mmHg; p = 0.049). However, offspring of mothers who exercised during pregnancy had increased total body fat (+3.2%; p = 0.034) and greater abdominal (+4.1% android fat; p = 0.040) and gynoid (+3.5% gynoid fat; p = 0.042) adiposity compared with controls. Exercise interventions beginning during pregnancy may be beneficial to long-term maternal health. However, the initiation of exercise during pregnancy amongst sedentary mothers may be associated with adverse effects in the offspring during childhood. Larger follow-up studies are required to investigate long-term effects of exercise in pregnancy.

  • Aharony, Ofer
    et al.
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-7610001 Rehovot, Israel.
    Alday, Luis F.
    Univ Oxford, Math Inst, Radcliffe Observ Quarter, Andrew Wiles Bldg,Woodstock Rd, Oxford OX2 6GG, England.
    Bissi, Agnese
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Yacoby, Ran
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-7610001 Rehovot, Israel.
    The analytic bootstrap for large N Chern-Simons vector models2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 8, article id 166Article in journal (Refereed)
    Abstract [en]

    Three-dimensional Chern-Simons vector models display an approximate higher spin symmetry in the large N limit. Their single-trace operators consist of a tower of weakly broken currents, as well as a scalar a of approximate twist 1 or 2. We study the consequences of crossing symmetry for the four-point correlator of a in a 1/N expansion, using analytic bootstrap techniques. To order 1/N we show that crossing symmetry fixes the contribution from the tower of currents, providing an alternative derivation of well-known results by Maldacena and Zhiboedov. When sigma has twist 1 its OPE receives a contribution from the exchange of a itself with an arbitrary coefficient, due to the existence of a marginal sextic coupling. We develop the machinery to determine the corrections to the OPE data of double-trace operators due to this, and to similar exchanges. This in turns allows us to fix completely the correlator up to three known truncated solutions to crossing. We then proceed to study the problem to order 1/N-2. We find that crossing implies the appearance of odd-twist double-trace operators, and calculate their OPE coefficients in a large spin expansion. Also, surprisingly, crossing at order 1/N-2, implies non-trivial O(1/N) anomalous dimensions for even-twist double-trace operators, even though such contributions do not appear in the four-point function at order 1/N (in the case where there is no scalar exchange). We argue that this phenomenon arises due to operator mixing. Finally, we analyse the bosonic vector model with a sextic coupling without gauge interactions, and determine the order 1/N-2 corrections to the dimensions of twist-2 double-trace operators.

  • Bergen, K.
    et al.
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Frodin, M.
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    von Gertten, C.
    Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
    Sandberg-Nordqvist, A. -C
    Department of Clinical Neuroscience, Karolinska Institutet.
    Sköld, Mattias K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery. Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Neurite Growth and Polarization on Vitronectin Substrate after in Vitro Trauma is not Enhanced after IGF Treatment2018In: Brain Sciences, ISSN 2076-3425, E-ISSN 2076-3425, Vol. 8, no 8, article id 151Article in journal (Refereed)
    Abstract [en]

    Following traumatic brain injuries (TBI), insulin-like growth factor (IGF) is cortically widely upregulated. This upregulation has a potential role in the recovery of neuronal tissue, plasticity, and neurotrophic activity, though the molecular mechanisms involved in IGF regulation and the exact role of IGF after TBI remain unclear. Vitronectin (VN), an extracellular matrix (ECM) molecule, has recently been shown to be of importance for IGF-mediated cellular growth and migration. Since VN is downregulated after TBI, we hypothesized that insufficient VN levels after TBI impairs the potential beneficial activity of IGF. To test if vitronectin and IGF-1/IGFBP-2 could contribute to neurite growth, we cultured hippocampal neurons on +/- vitronectin-coated coverslips and them treated with +/- IGF-1/IGF binding protein 2 (IGFBP-2). Under same conditions, cell cultures were also subjected to in vitro trauma to investigate differences in the posttraumatic regenerative capacity with +/- vitronectin-coated coverslips and with +/- IGF-1/IGFBP-2 treatment. In both the control and trauma situations, hippocampal neurons showed a stronger growth pattern on vitronectin than on the control substrate. Surprisingly, the addition of IGF-1/IGFBP-2 showed a decrease in neurite growth. Since neurite growth was measured as the number of neurites per area, we hypothesized that IGF-1/IGFBP-2 contributes to the polarization of neurons and thus induced a less dense neurite network after IGF-1/IGFBP-2 treatment. This hypothesis could not be confirmed and we therefore conclude that vitronectin has a positive effect on neurite growth in vitro both under normal conditions and after trauma, but that addition of IGF-1/IGFBP-2 does not have a positive additive effect.

  • Wessler, Heinz Werner
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Vishnu Khare: Hindi ka khara kavi2018In: Garbhnal, ISSN 2249-5967, Vol. 8, no 8, p. 6-7Article in journal (Other (popular science, discussion, etc.))
  • Wessler, Heinz Werner
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Eine katholische Nationalheilige fuer Pakistan?: Ruth Pfau (1929-2017) und das Elend der Welt2018In: Stimmen der Zeit, ISSN 0039-1492, Vol. 236, no 6, p. 385-394Article in journal (Refereed)
  • Wessler, Heinz Werner
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Bhentvarta: Namita Khare se2018In: Garbhnal, ISSN 2249-5967, Vol. 8, no 6, p. 30-32Article in journal (Other (popular science, discussion, etc.))
  • Heritier, K. L.
    et al.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England.
    Galand, M.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England.
    Henri, P.
    Univ Orleans, CNRS, LPC2E, F-45100 Orleans, France.
    Johansson, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Beth, A.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England.
    Eriksson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Vallieres, X.
    Univ Orleans, CNRS, LPC2E, F-45100 Orleans, France.
    Altwegg, K.
    Univ Bern, Inst Phys, Sidlerstr 5, CH-3012 Bern, Switzerland.
    Burch, J. L.
    Southwest Res Inst, PO Drawer 28510, San Antonio, TX 78228 USA.
    Carr, C.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England.
    Ducrot, E.
    Imperial Coll London, Dept Phys, Prince Consort Rd, London SW7 2AZ, England;Univ Liege, Space Sci Technol & Astrophys Res STAR Inst, B-4000 Liege, Belgium.
    Hajra, R.
    Univ Orleans, CNRS, LPC2E, F-45100 Orleans, France.
    Rubin, M.
    Univ Bern, Inst Phys, Sidlerstr 5, CH-3012 Bern, Switzerland.
    Plasma source and loss at comet 67P during the Rosetta mission2018In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 618, article id A77Article in journal (Refereed)
    Abstract [en]

    Context. The Rosetta spacecraft provided us with a unique opportunity to study comet 67P/Churyumov-Gerasimenko (67P) from a close perspective and over a 2-yr time period. Comet 67P is a weakly active comet. It was therefore unexpected to find an active and dynamic ionosphere where the cometary ions were largely dominant over the solar wind ions, even at large heliocentric distances. Aims. Our goal is to understand the different drivers of the cometary ionosphere and assess their variability over time and over the different conditions encountered by the comet during the Rosetta mission. Methods. We used a multi-instrument data-based ionospheric model to compute the total ion number density at the position of Rosetta. In-situ measurements from the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) and the Rosetta Plasma Consortium (RPC)-Ion and Electron Sensor (IES), together with the RPC-LAngmuir Probe instrument (LAP) were used to compute the local ion total number density. The results are compared to the electron densities measured by RPC-Mutual Impedance Probe (MIP) and RPC-LAP. Results. We were able to disentangle the physical processes responsible for the formation of the cometary ions throughout the 2-yr escort phase and we evaluated their respective magnitudes. The main processes are photo-ionization and electron-impact ionization. The latter is a significant source of ionization at large heliocentric distance (>2 au) and was predominant during the last 4 months of the mission. The ionosphere was occasionally subject to singular solar events, temporarily increasing the ambient energetic electron population. Solar photons were the main ionizer near perihelion at 1.3 au from the Sun, during summer 2015.

  • Svedberg, Jesper
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Hosseini, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Chen, Jun
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Vogan, Aaron A.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Mozgova, Iva
    Swedish Univ Agr Sci, Dept Plant Biol, POB 7080, SE-75007 Uppsala, Sweden;Swedish Univ Agr Sci, Linnean Ctr Plant Biol, POB 7080, SE-75007 Uppsala, Sweden;Czech Acad Sci, Inst Microbiol, Ctr Algatech, CZ-37981 Trebon, Czech Republic.
    Hennig, Lars
    Swedish Univ Agr Sci, Dept Plant Biol, POB 7080, SE-75007 Uppsala, Sweden;Swedish Univ Agr Sci, Linnean Ctr Plant Biol, POB 7080, SE-75007 Uppsala, Sweden.
    Manitchotpisit, Pennapa
    Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA.
    Abusharekh, Anna
    Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA.
    Hammond, Thomas M.
    Illinois State Univ, Sch Biol Sci, Normal, IL 61790 USA.
    Lascoux, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Johannesson, Hanna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 4242Article in journal (Refereed)
    Abstract [en]

    Meiotic drive is widespread in nature. The conflict it generates is expected to be an important motor for evolutionary change and innovation. In this study, we investigated the genomic consequences of two large multi-gene meiotic drive elements, Sk-2 and Sk-3, found in the filamentous ascomycete Neurospora intermedia. Using long-read sequencing, we generated the first complete and well-annotated genome assemblies of large, highly diverged, non-recombining regions associated with meiotic drive elements. Phylogenetic analysis shows that, even though Sk-2 and Sk-3 are located in the same chromosomal region, they do not form sister clades, suggesting independent origins or at least a long evolutionary separation. We conclude that they have in a convergent manner accumulated similar patterns of tandem inversions and dense repeat clusters, presumably in response to similar needs to create linkage between genes causing drive and resistance.

  • Plomion, Christophe
    et al.
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Aury, Jean-Marc
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Amselem, Joelle
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Leroy, Thibault
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Murat, Florent
    INRA UCA, GDEC, Clermont Ferrand, France.
    Duplessis, Sebastien
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Faye, Sebastien
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Francillonne, Nicolas
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Labadie, Karine
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Le Provost, Gregoire
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Lesur, Isabelle
    Univ Bordeaux, BIOGECO, INRA, Cestas, France;HelixVenture, Merignac, France.
    Bartholome, Jerome
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Faivre-Rampant, Patricia
    Univ Paris Saclay, INRA, US EPGV 1279, Evry, France.
    Kohler, Annegret
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Leple, Jean-Charles
    INRA, BIOFORA, Orleans, France.
    Chantret, Nathalie
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    Chen, Jun
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dievart, Anne
    CIRAD, UMR AGAP, Montpellier, France;Univ Montpellier, CIRAD, INRA, Montpellier SupAgro, Montpellier, France.
    Alaeitabar, Tina
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Barbe, Valerie
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Belser, Caroline
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Berges, Helene
    INRA, CNRGV, Castanet Tolosan, France.
    Bodenes, Catherine
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Bogeat-Triboulot, Marie-Beatrice
    Univ Lorraine, UMR Silva, INRA, AgroPariTech, Nancy, France.
    Bouffaud, Marie-Lara
    UFZ Helmholtz Ctr Environm Res, Dept Soil Ecol, Halle, Germany.
    Brachi, Benjamin
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Chancerel, Emilie
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Cohen, David
    Univ Lorraine, UMR Silva, INRA, AgroPariTech, Nancy, France.
    Couloux, Arnaud
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Da Silva, Corinne
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Dossat, Carole
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Ehrenmann, Francois
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Gaspin, Christine
    INRA, Plateforme Bioinformat Toulouse Midi Pyrenees, Auzeville Castanet Tolos, Germany.
    Grima-Pettenati, Jacqueline
    Univ Toulouse, CNRS, UMR 5546, LRSV, Castanet Tolosan, France.
    Guichoux, Erwan
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Hecker, Arnaud
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Herrmann, Sylvie
    German Ctr Integrat Res IDiv, Leipzig, Germany.
    Hugueney, Philippe
    Univ Strasbourg, SVQV, INRA, Colmar, France.
    Hummel, Irene
    Univ Lorraine, UMR Silva, INRA, AgroPariTech, Nancy, France.
    Klopp, Christophe
    INRA, Plateforme Bioinformat Toulouse Midi Pyrenees, Auzeville Castanet Tolos, Germany.
    Lalanne, Celine
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Lascoux, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Lasserre, Eric
    Univ Perpignan, UMR 5096, Perpignan, France.
    Lemainque, Arnaud
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Desprez-Loustau, Marie-Laure
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Luyten, Isabelle
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Madoui, Mohammed-Amin
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Mangenot, Sophie
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Marchal, Clemence
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Maumus, Florian
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Mercier, Jonathan
    CEA, Genoscope, Inst Biol Francois Jacob, Evry, France.
    Michotey, Celia
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Panaud, Olivier
    Univ Perpignan, UMR 5096, Perpignan, France.
    Picault, Nathalie
    Univ Perpignan, UMR 5096, Perpignan, France.
    Rouhier, Nicolas
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Rue, Olivier
    INRA, Plateforme Bioinformat Toulouse Midi Pyrenees, Auzeville Castanet Tolos, Germany.
    Rustenholz, Camille
    Univ Strasbourg, SVQV, INRA, Colmar, France.
    Salin, Franck
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Soler, Marcal
    Univ Toulouse, CNRS, UMR 5546, LRSV, Castanet Tolosan, France;Univ Girona, Lab Suro, Girona, Spain.
    Tarkka, Mika
    UFZ Helmholtz Ctr Environm Res, Dept Soil Ecol, Halle, Germany.
    Velt, Amandine
    Univ Strasbourg, SVQV, INRA, Colmar, France.
    Zanne, Amy E.
    George Washington Univ, Dept Biol Sci, Washington, DC 20052 USA.
    Martin, Francis
    Univ Lorraine, IAM, INRA, Champenoux, France.
    Wincker, Patrick
    Univ Paris Saclay, Genom Metab, Genoscope, Inst Biol Francois Jacob,CEA,CNRS,Univ Evry, Evry, France.
    Quesneville, Hadi
    Univ ParisSaclay, URGI, INRA, Versailles, France.
    Kremer, Antoine
    Univ Bordeaux, BIOGECO, INRA, Cestas, France.
    Salse, Jerome
    INRA UCA, GDEC, Clermont Ferrand, France.
    Oak genome reveals facets of long lifespan2018In: NATURE PLANTS, ISSN 2055-026X, Vol. 4, no 7, p. 440-452Article in journal (Refereed)
    Abstract [en]

    Oaks are an important part of our natural and cultural heritage. Not only are they ubiquitous in our most common landscapes' but they have also supplied human societies with invaluable services, including food and shelter, since prehistoric times(2). With 450 species spread throughout Asia, Europe and America(3), oaks constitute a critical global renewable resource. The longevity of oaks (several hundred years) probably underlies their emblematic cultural and historical importance. Such long-lived sessile organisms must persist in the face of a wide range of abiotic and biotic threats over their lifespans. We investigated the genomic features associated with such a long lifespan by sequencing, assembling and annotating the oak genome. We then used the growing number of whole-genome sequences for plants (including tree and herbaceous species) to investigate the parallel evolution of genomic characteristics potentially underpinning tree longevity. A further consequence of the long lifespan of trees is their accumulation of somatic mutations during mitotic divisions of stem cells present in the shoot apical meristems. Empirical(4) and modelling(5) approaches have shown that intra-organismal genetic heterogeneity can be selected for(6) and provides direct fitness benefits in the arms race with short-lived pests and pathogens through a patchwork of intra-organismal phenotypes(7). However, there is no clear proof that large-statured trees consist of a genetic mosaic of clonally distinct cell lineages within and between branches. Through this case study of oak, we demonstrate the accumulation and transmission of somatic mutations and the expansion of disease-resistance gene families in trees.

  • Kensert, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Alvarsson, Jonathan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Norinder, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Spjuth, Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Evaluating parameters for ligand-based modeling with random forest on sparse data sets2018In: Journal of Cheminformatics, ISSN 1758-2946, E-ISSN 1758-2946, Vol. 10, article id 49Article in journal (Refereed)
    Abstract [en]

    Ligand-based predictive modeling is widely used to generate predictive models aiding decision making in e.g. drug discovery projects. With growing data sets and requirements on low modeling time comes the necessity to analyze data sets efficiently to support rapid and robust modeling. In this study we analyzed four data sets and studied the efficiency of machine learning methods on sparse data structures, utilizing Morgan fingerprints of different radii and hash sizes, and compared with molecular signatures descriptor of different height. We specifically evaluated the effect these parameters had on modeling time, predictive performance, and memory requirements using two implementations of random forest; Scikit-learn as well as FEST. We also compared with a support vector machine implementation. Our results showed that unhashed fingerprints yield significantly better accuracy than hashed fingerprints (p <= 0.05), with no pronounced deterioration in modeling time and memory usage. Furthermore, the fast execution and low memory usage of the FEST algorithm suggest that it is a good alternative for large, high dimensional sparse data. Both support vector machines and random forest performed equally well but results indicate that the support vector machine was better at using the extra information from larger values of the Morgan fingerprint's radius.

  • Manichaikul, Ani
    et al.
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA;Univ Virginia, Dept Publ Hlth Sci, Biostat Sect, Charlottesville, VA USA.
    Wang, Xin-Qun
    Univ Virginia, Dept Publ Hlth Sci, Biostat Sect, Charlottesville, VA USA.
    Li, Li
    PAREXEL Int, Genom Med, Durham, NC USA.
    Erdmann, Jeanette
    Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany;DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg, Lubeck, Germany.
    Lettre, Guillaume
    Montreal Heart Inst, Montreal, PQ, Canada;Univ Montreal, Montreal, PQ, Canada.
    Bis, Joshua C.
    Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA;Univ Washington, Dept Med, Seattle, WA USA.
    Waterworth, Dawn
    GlaxoSmithKline, Genet, King Of Prussia, PA USA.
    Cushman, Mary
    Univ Vermont, Dept Med, Burlington, VT USA;Univ Vermont, Dept Pathol & Lab Med, Burlington, VT USA.
    Jenny, Nancy S.
    Univ Vermont, Dept Pathol & Lab Med, Burlington, VT USA.
    Post, Wendy S.
    Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
    Palmas, Walter
    Columbia Univ, Coll Phys & Surg, Dept Med, Div Gen Med, New York, NY USA.
    Tsai, Michael Y.
    Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    White, Harvey
    Auckland City Hosp Green Lane Cardiovasc Sci, Auckland, New Zealand.
    Schunkert, Heribert
    DZHK German Res Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
    O'Donnell, Christopher J.
    Boston Vet Adm Healthcare, Cardiol Sect, Boston, MA USA;NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA.
    Herrington, David M.
    Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC 27103 USA.
    Rich, Stephen S.
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA;Univ Virginia, Dept Publ Hlth Sci, Biostat Sect, Charlottesville, VA USA.
    O'Donoghue, Michelle L.
    Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA.
    Rodriguez, Annabelle
    Univ Connecticut Hlth, Dept Cell Biol, Ctr Vasc Biol, Farmington, CT 06030 USA.
    Lp-PLA(2), scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 10, article id e0204352Article in journal (Refereed)
    Abstract [en]

    Background We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been reported in association with Lp-PLA(2) mass and activity, we hypothesized that inflammatory pathways might mediate the association of rs10846744 with atherosclerosis. Methods We first examined association of rs10846744 in CVD in multiple large-scale consortium-based genome-wide association studies. We further examined 27 parameters of interest, including Lp-PLA(2) mass and activity, inflammatory markers, and plasma phospholipid fatty acids, and fatty acid ratios in participants from the Multi-Ethnic Study of Atherosclerosis (MESA), as potential mediators in the pathway linking rs10846744 with cIMT and incident CVD. Finally, we examined the association of rs10846744 with Lp-PLA(2) activity, cardiovascular outcomes, and interaction with the Lp-PLA(2) inhibitor, darapladib, in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy (STABILITY) and Stabilization of Plaque using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) studies. Results SCARB1 rs10846744 was associated with coronary artery disease events in CARDIo-GRAMplusC4D (odds ratio 1.05; 95% CI [1.02, 1.07]; P= 1.4x10(-4)). In combined analysis across race/ethnic groups in MESA, rs10846744 was associated with Lp-PLA(2 )mass (P= 0.04) and activity (P = 0.001), homocysteine (P = 0.03), LDL particle number (P = 0.01), docosahexaenoic acid [DHA] (P = 0.01), docosapentaenoic acid [DPA] (P = 0.04), DPA/eicosapentaenoic acid [EPA] ratio (P= 0.002), and DHA/EPA ratio (P= 0.008). Lp-PLA(2) activity was identified as a mediator of rs10846744 with cIMT in a basic model (P = 8x10(-5)), but not after adjustment for CVD risk factors. There was no interaction or modifier effect of the Lp-PLA(2) inhibitor darapladib assignment on the relationship between rs10846744 and major CVD events in either STABILITY or SOLID-TIMI 52. Summary SCARB1 rs10846744 is significantly associated with Lp-PLA(2) activity, atherosclerosis, and CVD events, but Lp-PLA(2) activity is not a mediator in the association of rs10846744 with cIMT in MESA.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Prompt and non-prompt J/psi elliptic flow in Pb plus Pb collisions at root S-NN=5.02 TeV with the ATLAS detector2018In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, no 9, article id 784Article in journal (Refereed)
    Abstract [en]

    The elliptic flow of prompt and non-prompt J/psi was measured in the dimuon decay channel in Pb+Pb collisions at root S-NN = 5.02 TeV with an integrated luminosity of 0.42 nb(-1) with the ATLAS detector at the LHC. The prompt and non-prompt signals are separated using a two-dimensional simultaneous fit of the invariant mass and pseudo-proper decay time of the dimuon system from the J/psi decay. The measurement is performed in the kinematic range of dimuon transverse momentum and rapidity 9 < p(T) < 30 GeV, vertical bar y vertical bar < 2, and 0-60% collision centrality. The elliptic flow coefficient, v(2), is evaluated relative to the event plane and the results are presented as a function of transverse momentum, rapidity and centrality. It is found that prompt and non-prompt J/psi mesons have non-zero elliptic flow. Prompt J/psi v(2 )decreases as a function of p(T), while for non-prompt J/psi it is, with limited statistical significance, consistent with a flat behaviour over the studied kinematic region. There is no observed dependence on rapidity or centrality.

  • Olivares-Espinosa, Hugo
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Ecole Technol Super, Dept Mech Engn, 1100 Notre Dame Ouest, Montreal, PQ H3C 1K3, Canada.
    Breton, Simon-Philippe
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences. Nergica, 70 Rue Bolduc, Gaspe, PQ G4X 1G2, Canada.
    Nilsson, Karl
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Masson, Christian
    Ecole Technol Super, Dept Mech Engn, 1100 Notre Dame Ouest, Montreal, PQ H3C 1K3, Canada.
    Dufresne, Louis
    Ecole Technol Super, Dept Mech Engn, 1100 Notre Dame Ouest, Montreal, PQ H3C 1K3, Canada.
    Ivanell, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Assessment of Turbulence Modelling in the Wake of an Actuator Disk with a Decaying Turbulence Inflow2018In: Applied Sciences, E-ISSN 2076-3417, Vol. 8, no 9, article id 1530Article in journal (Refereed)
    Abstract [en]

    The characteristics of the turbulence field in the wake produced by a wind turbine model are studied. To this aim, a methodology is developed and applied to replicate wake measurements obtained in a decaying homogeneous turbulence inflow produced by a wind tunnel. In this method, a synthetic turbulence field is generated to be employed as an inflow of Large-Eddy Simulations performed to model the flow development of the decaying turbulence as well as the wake flow behind an actuator disk. The implementation is carried out on the OpenFOAM platform, resembling a well-documented procedure used for wake flow simulations. The proposed methodology is validated by comparing with experimental results, for two levels of turbulence at inflow and disks with two different porosities. It is found that mean velocities and turbulent kinetic energy behind the disk are well estimated. The development of turbulence lengthscales behind the disk resembles what is observed in the free flow, predicting the ambient turbulence lengthscales to dominate across the wake, with little effect of shear from the wake envelope. However, observations of the power spectra confirm that shear yields a boost to the turbulence energy within the wake noticeable only in the low turbulence case. The results obtained show that the present implementation can successfully be used in the modelling and analysis of turbulence in wake flows.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurements of Higgs boson properties in the diphoton decay channel with 36 fb(-1) of pp collision data at root s=13 TeV with the ATLAS detector2018In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 98, no 5, article id 052005Article in journal (Refereed)
    Abstract [en]

    Properties of the Higgs boson are measured in the two-photon final state using 36.1 fb(-1) of proton-proton collision data recorded at root s = 13 TeV by the ATLAS experiment at the Large Hadron Collider. Cross-section measurements for the production of a Higgs boson through gluon-gluon fusion, vector-boson fusion, and in association with a vector boson or a top-quark pair are reported. The signal strength, defined as the ratio of the observed to the expected signal yield, is measured for each of these production processes as well as inclusively. The global signal strength measurement of 0.99 +/- 0.14 improves on the precision of the ATLAS measurement at root s = 7 and 8 TeV by a factor of two. Measurements of gluon-gluon fusion and vector-boson fusion productions yield signal strengths compatible with the Standard Model prediction. Measurements of simplified template cross sections, designed to quantify the different Higgs boson production processes in specific regions of phase space, are reported. The cross section for the production of the Higgs boson decaying to two isolated photons in a fiducial region closely matching the experimental selection of the photons is measured to be 55 +/- 10 fb, which is in good agreement with the Standard Model prediction of 64 +/- 2 fb. Furthermore, cross sections in fiducial regions enriched in Higgs boson production in vector-boson fusion or in association with large missing transverse momentum, leptons or top-quark pairs are reported. Differential and double-differential measurements are performed for several variables related to the diphoton kinematics as well as the kinematics and multiplicity of the jets produced in association with a Higgs boson. These differential cross sections are sensitive to higher order QCD corrections and properties of the Higgs boson, such as its spin and CP quantum numbers. No significant deviations from a wide array of Standard Model predictions are observed. Finally, the strength and tensor structure of the Higgs boson interactions are investigated using an effective Lagrangian, which introduces additional CP-even and CP-odd interactions. No significant new physics contributions are observed.

  • Hanh, Tong Thi Hai
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development.
    Boonstra, Wiebren J.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development. Stockholm Resilience Ctr, Stockholm, Sweden.
    Can income diversification resolve social-ecological traps in small-scale fisheries and aquaculture in the global south?: A case study of response diversity in the Tam Giang lagoon, central Vietnam2018In: Ecology & society, ISSN 1708-3087, E-ISSN 1708-3087, Vol. 23, no 3, article id 16Article in journal (Refereed)
    Abstract [en]

    Small-scale fishers and aquaculturists in the global south often face reinforcing feedbacks between resource degradation and livelihood impoverishment, a situation conceptualized as a social-ecological trap. It is argued that these traps can be overcome through income diversification, i.e., livelihoods that are maintained from variable income sources. Our aim was to further scrutinize that claim using the concept of response diversity. To do so, we applied the concept and analyzed income diversification in the Tam Giang lagoon, central Vietnam. Based on our analysis, we argue that high diversity in income activities does not necessarily lead to an escape from social-ecological traps. Although diversity in income activities in the case of the Tam Giang lagoon is relatively high, fisheries-and aquaculture-related income activities continue to dominate livelihood portfolios. The various gear and structures that these activities include all exploit the same ecologies, habitats, and niches of the lagoon. This finding triggers questions concerning the relative contribution of income activities to household income, but also how activities are (differently) connected to natural environments. Income diversification can only sustain natural resources and improve human well-being if it truly transforms livelihoods by connecting local users in new ways to ecologies and societies.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Observation of Higgs boson production in association with a top quark pair at the LHC with the ATLAS detector2018In: Physics Letters B, ISSN 0370-2693, E-ISSN 1873-2445, Vol. 784, p. 173-191Article in journal (Refereed)
    Abstract [en]

    The observation of Higgs boson production in association with a top quark pair (t (t) over barH), based on the analysis of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the Large Hadron Collider, is presented. Using data corresponding to integrated luminosities of up to 79.8 fb(-1), and considering Higgs boson decays into b (b) over bar, WW*, tau(+)tau(-), gamma gamma, and ZZ*, the observed significance is 5.8 standard deviations, compared to an expectation of 4.9 standard deviations. Combined with the t (t) over barH searches using a dataset corresponding to integrated luminosities of 4.5 fb(-1) at 7 TeV and 20.3 fb(-1) at 8 TeV, the observed (expected) significance is 6.3 (5.1) standard deviations. Assuming Standard Model branching fractions, the total t (t) over barH production cross section at 13 TeV is measured to be 670 +/- 90(stat.)(-100)(+110)(syst.) fb, in agreement with the Standard Model prediction.

  • van Olmen, Josefien
    et al.
    Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium; University of Antwerp, Antwerp, Belgium.
    Delobelle, Peter
    University of Cape Town, Cape Town, South Africa.
    Guwatudde, David
    Makerere University College of Health Sciences, Kampala, Uganda.
    Absetz, Pilvikki
    University of Eastern Finland, Kuopio, Finland.
    Sanders, David
    University of the Western Cape, Cape Town, South Africa.
    Mölsted Alvesson, Helle
    Karolinska Institutet, Stockholm, Sweden.
    Puoane, Thandi
    University of Western Cape, Bellville, South Africa.
    Ostenson, Claes-Goran
    Karolinska Institutet, Stockholm, Sweden.
    Tomson, Göran
    Karolinska Institutet, Stockholm, Sweden.
    Mayega, Roy William
    Makerere University College of Health Sciences, Kampala, Uganda.
    Sundberg, Carl Johan
    Karolinska Institutet, Stockholm, Sweden.
    Peterson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Child Health and Nutrition. Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Daivadanam, Meena
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics. Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Using a cross-contextual reciprocal learning approach in a multisite implementation research project to improve self-management for type 2 diabetes2018In: BMJ Global Health, E-ISSN 2059-7908, Vol. 3, no 6, article id 001068Article in journal (Refereed)
    Abstract [en]

    This paper reports on the use of reciprocal learning for identifying, adopting and adapting a type 2 diabetes self-management support intervention in a multisite implementation trial conducted in a rural setting in a low-income country (Uganda), a periurban township in a middle-income country (South Africa) and socioeconomically disadvantaged suburbs in a high-income country (Sweden). The learning process was guided by a framework for knowledge translation and structured into three learning cycles, allowing for a balance between evidence, stakeholder interaction and contextual adaptation. Key factors included commitment, common goals, leadership and partnerships. Synergistic outcomes were the cocreation of knowledge, interventions and implementation methods, including reverse innovations such as adaption of community-linked models of care. Contextualisation was achieved by cross-site exchanges and local stakeholder interaction to balance intervention fidelity with local adaptation. Interdisciplinary and cross-site collaboration resulted in the establishment of learning networks. Limitations of reciprocal learning relate to the complexity of the process with unpredictable outcomes and the limited generalisability of results.

  • Bernström, Ina
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Wedin, Kim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Skönlitteratur i undervisningen2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • Sundh, Pär
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Vad innehåller och vad förändras i matematikläroboken?: En läroboksanalys utifrån hur skriftliga räknemetoder har förändrats i läroböcker för årskurs 3 före och efter införandet av Lgr11.2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I ett tidigare arbete (Sundh, 2016), analyserade jag 8 matematikläroböcker för årskurs 3. Den analysen ligger som grund för den här studien som utvidgar analysen till att vidare undersöka hur läroböcker inom matematik för årskurs 3 speglar kunskapskraven i respektive styrdokument Lpo94 och Lgr11, med fokus på skriftliga räknemetoder inom addition och subtraktion. Det jag med denna studie vill tillföra är de likheter och skillnader som syns mellan tidigare läroböcker i jämförelse med deras reviderade utgåvor. Studien grundar sig även utifrån det faktum att undervisningen i matematik har en tradition av att vara starkt beroende av att använda läroboken som en struktur att planera undervisningen från. Studien grundar sig även på att det sedan 1991 inte längre finns någon statlig förhandsgranskning av läroböcker som avgör deras anpassning till kursplanens krav. Slutligen grundar sig studien också på det faktum att det inte verkar finnas så mycket vetenskapliga studier i Sverige som berör samma område som denna studie behandlar. Detta är i alla fall inget som har gått att hitta under genomförandet av denna studie..

    De frågeställningar som ligger till grund för studien är följande:Hur behandlas skriftliga räknemetoder i läroböckerna samt vilken räknemetod är mest dominerande?Vilka likheter och skillnader förekommer i läroböckerna före och efter införandet av Lgr11 utifrån hur skriftliga metoder används? För att besvara studiens frågeställningar och uppnå syftet så har en komparativ innehållsanalys av 20 läroböcker genomförts. Inför innehållsanalysen användes ett analysinstrument som bestod av undersökningsfrågor som var anpassade för att svara mot studiens syfte och frågeställningar. Utifrån resultatet av innehållsanalysen framkommer en stor variation i hur stor del av de analyserade läroböckerna tillämpar skriftliga räknemetoder inom addition och subtraktion. Variationen gör sig också tydlig i hur många olika räknemetoder som dessa läroböcker erbjuder vid utförandet av skriftliga räknemetoder. Resultatet visar att alla läroböckerna går i linje med respektive styrdokument men på olika sätt. Både Lpo94 och Lgr11 innehåller samma grundläggande kunskapssyn inom ämnet matematik, men att det formuleras och struktureras på olika sätt. Med detta i fokus kan man dock med hänsyn till resultatet som denna studie tillför se hur läroboksförfattarna väljer att förändra sina reviderade läroböcker på väldigt olika sätt. Det verkar inte finnas någon typ av samstämmighet mellan läroboksförfattarna i hur de väljer att uppgifter med skriftliga räknemetoder ska finnas representerade i läroböckerna. Detta för att de gör helt olika i vilken riktning som de väljer att förändra sina reviderade läroböcker som ska gå i linje med Lgr11.

  • Holik, Lukas
    et al.
    Brno University of Technology, Czech Republic.
    Janku, Petr
    Brno University of Technology, Czech Republic.
    Lin, Anthony W.
    University of Oxford, United Kingdom.
    Rümmer, Philipp
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Vojnar, Tomas
    Brno University of Technology, Czech Republic.
    String constraints with concatenation and transducers solved efficiently2018In: Proceedings of the ACM on Programming Languages, E-ISSN 2475-1421, Vol. 2, p. 1-32, article id 4Article in journal (Refereed)
    Abstract [en]

    String analysis is the problem of reasoning about how strings are manipulated by a program. It has numerous applications including automatic detection of cross-site scripting, and automatic test-case generation. A popular string analysis technique includes symbolic executions, which at their core use constraint solvers over the string domain, a.k.a. string solvers. Such solvers typically reason about constraints expressed in theories over strings with the concatenation operator as an atomic constraint. In recent years, researchers started to recognise the importance of incorporating the replace-all operator (i.e. replace all occurrences of a string by another string) and, more generally, finite-state transductions in the theories of strings with concatenation. Such string operations are typically crucial for reasoning about XSS vulnerabilities in web applications, especially for modelling sanitisation functions and implicit browser transductions (e.g. innerHTML). Although this results in an undecidable theory in general, it was recently shown that the straight-line fragment of the theory is decidable, and is sufficiently expressive in practice. In this paper, we provide the first string solver that can reason about constraints involving both concatenation and finite-state transductions. Moreover, it has a completeness and termination guarantee for several important fragments (e.g. straight-line fragment). The main challenge addressed in the paper is the prohibitive worst-case complexity of the theory (double-exponential time), which is exponentially harder than the case without finite-state transductions. To this end, we propose a method that exploits succinct alternating finite-state automata as concise symbolic representations of string constraints. In contrast to previous approaches using nondeterministic automata, alternation offers not only exponential savings in space when representing Boolean combinations of transducers, but also a possibility of succinct representation of otherwise costly combinations of transducers and concatenation. Reasoning about the emptiness of the AFA language requires a state-space exploration in an exponential-sized graph, for which we use model checking algorithms (e.g. IC3). We have implemented our algorithm and demonstrated its efficacy on benchmarks that are derived from cross-site scripting analysis and other examples in the literature.

  • Hojjat, Hossein
    et al.
    Rochester Institute of Technology, University of Tehran.
    Rümmer, Philipp
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    The Eldarica Horn Solver2018In: Formal Methods in Computer Aided Design 2018, IEEE, 2018Conference paper (Refereed)
  • Dian, E.
    et al.
    Hungarian Acad Sci, Budapest, Hungary;European Spallat Source ERIC, Lund, Sweden.
    Klinkby, E.
    European Spallat Source ERIC, Lund, Sweden;Tech Univ Denmark, Lyngby, Denmark.
    Cooper-Jensen, Carsten P.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics. European Spallat Source ERIC, Lund, Sweden.
    Parkanyi, D.
    Hungarian Acad Sci, Budapest, Hungary.
    Hajdu, D.
    Hungarian Acad Sci, Budapest, Hungary.
    Osan, J.
    Hungarian Acad Sci, Budapest, Hungary;IAEA, Nucl Sci & Instrumentat Lab, Vienna, Austria.
    Patriskov, G.
    Hungarian Acad Sci, Budapest, Hungary.
    Filges, U.
    Hungarian Acad Sci, Budapest, Hungary;PSI, Villigen, Switzerland.
    Bentley, Phillip M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics. European Spallat Source ERIC, Lund, Sweden.
    Preparation for activation measurements of concrete and PE-B4C-concrete to be applied for shielding at the European Spallation Source2018In: 22nd Meeting of the International Collaboration on Advanced Neutron Sources (ICANS XXII), Institute of Physics Publishing (IOPP), 2018, Vol. 1021, article id 012050Conference paper (Refereed)
    Abstract [en]

    To improve the effect of the concrete below 10 MeV where iron has resonances in the cross section, a new concrete have been developed. The PE-B4C-concrete utilizes hydrogen containing PE to thermalize the neutron and boron for in situ absorption. It is of utmost importance that the activation of the shielding material itself is well-understood, since it is planned to be used at the ESS. The first steps in this direction are shown the present study, in which concrete as well as reference aluminium samples are subject to XRF measurements to precisely determine the element content. This is compared to data sheets from the vender, and simulations are carried out to predict the sample activity. The samples are planned for insertion into the the Budapest Research Reactor, followed be activity and spectral measurements.

  • Åström, Staffan
    et al.
    Carlsson, Bengt
    Svensk Botanisk Tidskrift: Generalregister till volym 81-100 (1987-2006)2008Collection (editor) (Other academic)
  • Eriksson, Ove
    et al.
    Eriksson, MatsSnogerup, Britt
    Svensk Botanisk Tidskrift: Generalregister till volym 61-80 (1967-1986)1987Collection (editor) (Other academic)
  • Peterson, Gunnel
    et al.
    Peterson, Bo
    Svensk Botanisk Tidskrift: Generalregister till volym 41-60 (1947-1966)1971Collection (editor) (Other academic)
  • Ivanova, T.
    et al.
    Bulgarian Acad Sci, Cent Lab Solar Energy & New Energy Sources, 72 Tzarigradsko Chaussee, BU-1784 Sofia, Bulgaria.
    Harizanova, A.
    Bulgarian Acad Sci, Cent Lab Solar Energy & New Energy Sources, 72 Tzarigradsko Chaussee, BU-1784 Sofia, Bulgaria.
    Koutzarova, T.
    Bulgarian Acad Sci, E Djakov Inst Elect, 72 Tzarigradsko Chaussee, BU-1784 Sofia, Bulgaria.
    Vertruyen, B.
    Univ Liege, LCIS SUPRATECS, Inst Chem B6, B-4000 Liege, Belgium.
    Stefanov, Bozhidar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Structural and morphological properties of sol-gel ZnO:Ni films2018In: 20th International Summer School on Vacuum, Electron and Ion Technologies, 2017, Institute of Physics Publishing (IOPP), 2018, Vol. 992, article id 012044Conference paper (Refereed)
    Abstract [en]

    Ni doping induces modifications and considerable changes in the optical, electrical and magnetic properties of ZnO films. In this work, the influence is discussed of Ni-doping (two nickel concentrations) and annealing temperature (ranging from 300 degrees C to 800 degrees C) on the structural and optical properties of sol-gel derived ZnO: Ni films. Uniform and smooth films were obtained by spin-coating on quartz and Si substrates. The ZnO: Ni films were crystallized in wurtzite phase with no impurity phases found for annealing temperatures up to 600 degrees C. The size of the crystallites was strongly affected by the Ni content and the heat treatment. Furthermore, the Ni doping improved the optical transparency of the sol-gel films, while the AFM studies showed that the film morphology and the roughness were influenced by the nickel doping.

  • Peterson, Bo
    Svensk Botanisk Tidskrift: Generalregister till volym 21-40 (1927-1946)1949Collection (editor) (Other academic)
  • Arwidsson, Th.
    et al.
    Cedergren, G.R.
    Svensk Botanisk Tidskrift: Generalregister till volym 1-20 (1907-1926)1932Collection (editor) (Other academic)
  • Aronsson, Niklas
    Vilda Växter: Nummer 1. Mars 20142014Collection (editor) (Other academic)
    Abstract [en]

    Blåsippan - kommer i många former. Från fältet: Botanikläger för unga. Pärlan: Riddersholm på Rådmansö i Uppland. Förvildat: Öländska rymlingar. Lär dig hitta i floran: Gunnar Björndahl plöjer djupare. Kniviga artpar: Rödkämpar och svartkämpar. Personligt: Pontus Johansson. I Linnés fotspår: Pehr Kalm. Björnbär: Lär känna de olika sorterna. Resan: Orkidéer i Malawi. Nyttoväxter: Björkens användning. Från läsarna: Uncas Liljefors.

  • Aronsson, Niklas
    Vilda Växter: Nummer 2. November 20132013Collection (editor) (Other academic)
    Abstract [en]

    Tranbär: Underskattat myrguld. Innehåll och ledare: Stefan Grundström berättar om Vilda Växter. Från fältet: Dvärgandmat - ny art för Sverige. Pärlan: Villmyran i Ångermanland. Under luppen: Sveriges giftigaste växter. Livsviktig läsning. Lär dig hitta i floran: Gunnar Björndahl visar Kroken. Personligt: Johanna Emgård gav ut en egen flora. I Linnés fotspår: Carl Peter Thunberg - Japans Linné. Kniviga artpar: Rödklöver eller skogsklöver, det är frågan? Resan: Island - kargt men vackert. Johannesört: Johannesörten - nyttjad och älskad. Från läsarna: Åsa Lundqvist från Jämtland.

  • Aronsson, Niklas
    Vilda Växter: Nummer 2. Maj 20142014Collection (editor) (Other academic)
    Abstract [en]

    Vita blommor - Naturen är nyckfull. De vilda blommornas dag: Program finns på hemsidan. Floraväktarna: Fler behövs för att klara uppdraget. Vårens efterlängtade violet: Stark ställning i kulturhistorien. Lär dig hitta i floran, Del 4: Pentandria: Gunnar Björndahl kollar på gullvivor. Personligt: Bo Mossberg, illustrationer i världsklass. Kniviga artpar: Sumpstarr eller dystarr? Sex på mossors vis: Närgånget skildrat. Orkidéer på Sardinien: Följ med Sven Hansson till den italienska ön. Nyttoväxter: Så kan du använda lavarna i skogen. Midsommarnatt i norr: Blommande nornor förför. Makro: Hasselblomma i närbild.

  • Aronsson, Niklas
    Vilda Växter: Nummer 3. Augusti 20142014Collection (editor) (Other academic)
    Abstract [en]

    Hjortron - eftertraktad klassiker. Från fältet: Synpunkter på hemsidan efterlyses. Floraväktarna: Ut i skogen och leta efter ryl. Botanikläger: Ungdomsläger i Kullaberg. Lär dig hitta i floran: Gräs, halvgräs och tåg. Personlignt: Kurt-Anders Johansson. Pärlan: Österplana hed på Kinnekulle. Slåtterängen: Målaängen utanför Ulrika. Snyltrötter: Läs om våra åtta vilda snyltrötter. Växtbruk: Kärleksört. Från läsarna: Anna Göthelid. Makro: Höstfibblans fröställning.

  • Aronsson, Niklas
    Vilda Växter: Nummer 1. September 20132013Collection (editor) (Other academic)
    Abstract [en]

    Anpassning: Orkidéerna - Växtrikets falskspelare. Innehåll och ledare: Stefan Grundström berättar om Vilda Växter. Från fältet: Vilda blommornas dag och Botanikdagarna. Pärlan: Gossbydal i Torslanda. Under luppen: Turerna kring Bunge på Gotland har varit många. Lär dig hitta i floran: Gunnar Björndahl lär dig nycklingens konst. Personligt: Evastina Blomgren har järnkoll på floran i Bohuslän. I Linnés fotspår: Vem var egentligen Daniel Solander? Fångat: Mnemosynefjärilen och nunneörten. Resan: Kreta är tulpanernas förlovade land. Floraväktare: Härjedalen har fått besök av ett gäng floraväktare. Från läsarna.