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Rozental, A., Kottorp, A., Forsstrom, D., Månsson, K. N. .., Boettcher, J., Andersson, G., . . . Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559-572
Åpne denne publikasjonen i ny fane eller vindu >>The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments
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2019 (engelsk)Inngår i: Behavioural and Cognitive Psychotherapy, ISSN 1352-4658, E-ISSN 1469-1833, Vol. 47, nr 5, s. 559-572Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Psychological treatments provide many benefits for patients with psychiatric disorders, but research also suggests that negative effects might occur from the interventions involved. The Negative Effects Questionnaire (NEQ) has previously been developed as a way of determining the occurrence and characteristics of such incidents, consisting of 32 items and six factors. However, the NEQ has yet to be examined using modern test theory, which could help to improve the understanding of how well the instrument works psychometrically.

Aims: The current study investigated the reliability and validity of the NEQ from both a person and item perspective, establishing goodness-of-fit, item bias, and scale precision.

Method: The NEQ was distributed to 564 patients in five clinical trials at post-treatment. Data were analysed using Rasch analysis, i.e. a modern test theory application.

Results: (1) the NEQ exhibits fairness in testing across sociodemographics, (2) shows comparable validity for a final and condensed scale of 20 instead of 32 items, (3) uses a rating scale that advances monotonically in steps of 0 to 4, and (4) is suitable for monitoring negative effects on an item-level.

Conclusions: The NEQ is proposed as a useful instrument for investigating negative effects in psychological treatments, and its newer shorter format could facilitate its use in clinical and research settings. However, further research is needed to explore the relationship between negative effects and treatment outcome, as well as to test it in more diverse patient populations.

Emneord
negative effects, Negative Effects Questionnaire, psychological treatments, Rasch analysis
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-394254 (URN)10.1017/S1352465819000018 (DOI)000483716500006 ()30871650 (PubMedID)
Tilgjengelig fra: 2019-10-11 Laget: 2019-10-11 Sist oppdatert: 2019-10-11bibliografisk kontrollert
Lindner, P., Miloff, A., Fagernäs, S., Andersen, J., Sigeman, M., Andersson, G., . . . Carlbring, P. (2019). Therapist-led and self-led one-session virtual reality exposure therapy for public speaking anxiety with consumer hardware and software: A randomized controlled trial. Journal of Anxiety Disorders, 61, 45-54
Åpne denne publikasjonen i ny fane eller vindu >>Therapist-led and self-led one-session virtual reality exposure therapy for public speaking anxiety with consumer hardware and software: A randomized controlled trial
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2019 (engelsk)Inngår i: Journal of Anxiety Disorders, ISSN 0887-6185, E-ISSN 1873-7897, Vol. 61, s. 45-54Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Public speaking anxiety (PSA) is a common condition which can be treated effectively with exposure therapy. However, inherent difficulties in stimuli presentation and control limits dissemination and the therapeutic potential. Virtual Reality (VR) technology has the potential to resolve these issues and provide a scalable platform for self-help interventions. No previous study has examined whether this can be achieved using the first generation of consumer VR hardware and software. In the current trial, n = 25 + 25 participants were randomized to either one-session therapist-led VR exposure therapy for PSA followed by a four-week internet-administered VR to in-vivo transition program, or a waiting-list. Linear mixed effects modeling revealed significant, large (within Cohen’s d = 1.67) decreases in self-reported PSA. The waiting-list was then given access to an internet-administered, self-led version of the same VR exposure therapy to be conducted at home, followed by the same transition program. Dual-slope mixed effects modeling revealed significant, large (d = 1.35) decreases in self-reported PSA. Results were maintained or improved at six- and twelve-month follow-ups. We show for the first time that low-cost, off-the-shelf consumer VR hardware and software can be used to conduct exposure therapy for PSA, both in the traditional, previously impractical one-session format, and in a novel self-led, at-home format.

Emneord
Virtual reality, Exposure therapy, Internet interventions, Social anxiety disorder, Public speaking anxiety, In-vivo
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-358454 (URN)10.1016/j.janxdis.2018.07.003 (DOI)000456898000006 ()30054173 (PubMedID)
Merknad

Correction in: JOURNAL OF ANXIETY DISORDERS, Volume: 64, Pages: 90-90, DOI: 10.1016/j.janxdis.2019.04.002

Tilgjengelig fra: 2018-08-29 Laget: 2018-08-29 Sist oppdatert: 2019-06-19bibliografisk kontrollert
Månsson, K., Garrett, D., Manzouri, A., Wiegert, S., Furmark, T. & Fischer, H. (2018). Affective Brain Signal Variability Separates Social Anxiety Disorder Patients From Healthy Individuals. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S249-S250
Åpne denne publikasjonen i ny fane eller vindu >>Affective Brain Signal Variability Separates Social Anxiety Disorder Patients From Healthy Individuals
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2018 (engelsk)Inngår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S249-S250Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Social Anxiety Disorder, BOLD fMRI, Variability
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-359379 (URN)10.1016/j.biopsych.2018.02.644 (DOI)000433001900042 ()
Konferanse
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Tilgjengelig fra: 2018-09-17 Laget: 2018-09-17 Sist oppdatert: 2018-09-17bibliografisk kontrollert
Kraus, J., Frick, A., Fischer, H., Howner, K., Fredriksson, M. & Furmark, T. (2018). Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder. Psychiatry Research: Neuroimaging, 280, 56-61
Åpne denne publikasjonen i ny fane eller vindu >>Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
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2018 (engelsk)Inngår i: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 280, s. 56-61Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Emneord
Social phobia, Emotional faces, International Affective Picture System, IAPS, fMRI, Fear
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-364125 (URN)10.1016/j.pscychresns.2018.08.012 (DOI)000443824900008 ()30165271 (PubMedID)
Forskningsfinansiär
Swedish Research CouncilRiksbankens JubileumsfondRiksbankens JubileumsfondThe Swedish Brain Foundation
Tilgjengelig fra: 2018-11-05 Laget: 2018-11-05 Sist oppdatert: 2018-11-05bibliografisk kontrollert
Frick, A., Engman, J., Wahlstedt, K., Gingnell, M., Fredrikson, M. & Furmark, T. (2018). Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder. BJPsych bulletin, 4(3)
Åpne denne publikasjonen i ny fane eller vindu >>Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder
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2018 (engelsk)Inngår i: BJPsych bulletin, ISSN 2056-4694, E-ISSN 2056-4708, Vol. 4, nr 3Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We aimed to identify biomarkers to guide the decision to add selective serotonin reuptake inhibitors (SSRI) to psychological treatment for social anxiety disorder (SAD). Forty-eight patients with SAD underwent functional magnetic resonance imaging and collection of clinical and demographic variables before treatment with cognitive–behavioural therapy, combined on a double-blind basis with either escitalopram or placebo for 9 weeks. Pre-treatment neural reactivity to aversive faces in the dorsal anterior cingulate cortex (ACC), but not clinical/demographic variables, moderated clinical outcomes. Cross-validated individual-level predictions accurately identified 81% of responders/non-responders. Dorsal ACC reactivity is thus a potential biomarker for SAD treatment selection.

sted, utgiver, år, opplag, sider
Cambridges Institutes Press, 2018
Emneord
Functional magnetic resonance imaging, anxiety, prediction, selective serotonin reuptake inhibitors, cognitive–behavioural therapy, social phobia
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-353596 (URN)10.1192/bjo.2018.15 (DOI)000436933400012 ()29922481 (PubMedID)
Forskningsfinansiär
Swedish Research CouncilRiksbankens JubileumsfondThe Swedish Brain FoundationForte, Swedish Research Council for Health, Working Life and WelfareSwedish Society for Medical Research (SSMF)
Tilgjengelig fra: 2018-06-14 Laget: 2018-06-14 Sist oppdatert: 2018-09-26bibliografisk kontrollert
Motilla Hoppe, J., Frick, A., Åhs, F., Linnman, C., Appel, L., Jonasson, M., . . . Furmark, T. (2018). Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits. Translational Psychiatry, 8(1), 168
Åpne denne publikasjonen i ny fane eller vindu >>Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits
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2018 (engelsk)Inngår i: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 8, nr 1, s. 168-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress and anxiety-related behavior. Alterations in the SP-NK1 system have also been observed in human anxiety disorders, yet little is known about the relation between this system and individual differences in personality traits associated with anxiety propensity and approach-avoidance behavior, including trait anxiety, neuroticism, and extraversion. Exploring this relation could provide important insights into the neurobiological underpinnings of human anxiety and the etiology of anxiety disorders, as anxious traits are associated with increased susceptibility to develop psychopathological conditions. Here we examined the relationship between central NK1 receptor availability and self-rated measures of trait anxiety, neuroticism, and extraversion. The amygdala was chosen as the primary region of interest since this structure has been suggested to mediate the effect of the SP-NK1 system on anxiety. Anxious traits and NK1 receptor availability, determined with positron emission tomography and the radiotracer [11C]GR205171, were measured in 17 healthy individuals. Voxel-wise analyses showed a significant positive correlation between bilateral amygdala NK1 receptor availability and trait anxiety, and a trend in similar direction was observed for neuroticism. Conversely, extraversion was found to be negatively associated with amygdala NK1 receptor availability. Extraversion also correlated negatively with the NK1 measure in the cuneus/precuneus and fusiform gyrus according to exploratory whole-brain analyses. In conclusion, our findings indicate that amygdala NK1 receptor availability is associated with anxiety-related personality traits in healthy subjects, consistent with a modulatory role for the SP-NK1 system in human anxiety.

HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-358759 (URN)10.1038/s41398-018-0163-1 (DOI)000443079700001 ()
Tilgjengelig fra: 2018-08-31 Laget: 2018-08-31 Sist oppdatert: 2018-12-10bibliografisk kontrollert
Mansson, K., Wager, T. D., Isacsson, N., Kolbeinsson, O., Andersson, G., Fischer, H. & Furmark, T. (2018). Brain Before Behavior: Temporal Dynamics in the Treatment of Social Anxiety - Neural Changes Occur Early and Precede Clinical Improvement. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), 2018, New York, NY. Biological Psychiatry, 83(9), S130-S131
Åpne denne publikasjonen i ny fane eller vindu >>Brain Before Behavior: Temporal Dynamics in the Treatment of Social Anxiety - Neural Changes Occur Early and Precede Clinical Improvement
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2018 (engelsk)Inngår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S130-S131Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
Emneord
Social Anxiety Disorder, BOLD fMRI, Cognitive Behavior Therapy, Temporal Dynamics, Amygdala
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-361430 (URN)000432466300319 ()
Konferanse
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), 2018, New York, NY
Tilgjengelig fra: 2018-12-10 Laget: 2018-12-10 Sist oppdatert: 2018-12-10bibliografisk kontrollert
Månsson, K., Lindqvist, D., Yang, L., Wolkowitz, O., Nilsonne, G., Isung, J., . . . Furmark, T. (2018). Can Psychological Treatment Slow Down Cellular Aging in Social Anxiety Disorder?: An Intervention Study Evaluating Changes in Telomere Length and Telomerase Activity. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S351-S352
Åpne denne publikasjonen i ny fane eller vindu >>Can Psychological Treatment Slow Down Cellular Aging in Social Anxiety Disorder?: An Intervention Study Evaluating Changes in Telomere Length and Telomerase Activity
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2018 (engelsk)Inngår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S351-S352Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Telomerase, Telomere, Social Anxiety Disorder, Cognitive Behavior Therapy, Cellular Aging
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-359378 (URN)10.1016/j.biopsych.2018.02.904 (DOI)000433001900299 ()
Konferanse
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Merknad

Meeting Abstract: S13

Tilgjengelig fra: 2018-09-17 Laget: 2018-09-17 Sist oppdatert: 2018-09-17bibliografisk kontrollert
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E. & Nilson, K. W. (2018). Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents. Development and psychopathology (Print), 30(2), 449-459
Åpne denne publikasjonen i ny fane eller vindu >>Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents
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2018 (engelsk)Inngår i: Development and psychopathology (Print), ISSN 0954-5794, E-ISSN 1469-2198, Vol. 30, nr 2, s. 449-459Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Social anxiety is one of the most commonly reported mental health problems among adolescents, and it has been suggested that parenting style influences an adolescent's level of anxiety. A context-dependent effect of oxytocin on human social behavior has been proposed; however, research on the oxytocin gene (OXT) has mostly been reported without considering contextual factors. This study investigated the interactions between parenting style and polymorphic variations in the OXT gene in association with social anxiety symptoms in a community sample of adolescents (n = 1,359). Two single nucleotide polymorphisms linked to OXT, rs4813625 and rs2770378, were genotyped. Social anxiety and perceived parenting style were assessed by behavioral questionnaires. In interaction models adjusted for sex, significant interaction effects with parenting style were observed for both variants in relation to social anxiety. The nature of the interactions was in line with the differential susceptibility framework for rs4813625, whereas for rs2770378 the results indicated a diathesis–stress type of interaction. The findings may be interpreted from the perspective of the social salience hypothesis of oxytocin, with rs4813625 affecting social anxiety levels along a perceived unsafe–safe social context dimension.

HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-323574 (URN)10.1017/S0954579417000967 (DOI)000430924500006 ()28606214 (PubMedID)
Forskningsfinansiär
Fredrik och Ingrid Thurings StiftelseThe Swedish Brain Foundation, F02015-0315Forte, Swedish Research Council for Health, Working Life and Welfare, FORTE 2015-00897Åke Wiberg Foundation, MI5-0239Swedish Research Council, VR 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398Stiftelsen Söderström - Königska sjukhemmet, SLS-559921
Tilgjengelig fra: 2017-06-08 Laget: 2017-06-08 Sist oppdatert: 2019-04-04bibliografisk kontrollert
Groenewold, N., Bas-Hoogendam, J. M., Amod, A. R., van Velzen, L., Aghajani, M., Filippi, C., . . . van der Wee, N. J. J. (2018). Subcortical Volumes in Social Anxiety Disorder: Preliminary Results From Enigma-Anxiety. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S247-S248
Åpne denne publikasjonen i ny fane eller vindu >>Subcortical Volumes in Social Anxiety Disorder: Preliminary Results From Enigma-Anxiety
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2018 (engelsk)Inngår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S247-S248Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Structural MRI, Social Phobia, Thalamus, Meta-analysis, Harmonized Protocols
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-359376 (URN)10.1016/j.biopsych.2018.02.640 (DOI)000433001900038 ()
Konferanse
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Forskningsfinansiär
NIH (National Institute of Health), BD2K U54 EB020403
Tilgjengelig fra: 2018-09-17 Laget: 2018-09-17 Sist oppdatert: 2018-09-17bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-6821-9058