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Björvang, R. D., Liakea, I., Carpentsier, B., Kozinszky, Z., Skalkidou, A. & Fransson, E. (2024). Association of Diabetes Mellitus in Pregnancy and Perinatal Depression. Psychosomatic Medicine, 86(1), 52-58
Åpne denne publikasjonen i ny fane eller vindu >>Association of Diabetes Mellitus in Pregnancy and Perinatal Depression
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2024 (engelsk)Inngår i: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 86, nr 1, s. 52-58Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective 

Diabetes is frequently linked with depression, and both conditions are common complications during pregnancy. However, research findings exploring the relationship between diabetes mellitus in pregnancy (DMP) and perinatal depression (PND) have been inconsistent. Thus, this study seeks to examine the association between DMP and PND in a prospective population-based cohort.

Methods 

Women aged 18 to 48 years (n = 4459) were identified from the Biology, Affect, Stress, Imaging and Cognition study. The diagnosis of DMP was based on International Classification of Diseases code O24 from medical records and was classified as pregestational, gestational, or unspecified diabetes. PND was assessed using psychometric instruments, clinical interviews, and/or register data and categorized into antepartum or postpartum depression. Multivariable logistic regressions were used to study the associations of DMP with antepartum and postpartum depression. The association between DMP and continuous depression scores, antepartum and postpartum, was investigated with multivariable linear regressions.

Results 

Of 4459 pregnancies, 949 women had antepartum depression (21.2%) and 1123 had postpartum depression (25%). DMP had a prevalence of 1.2%. Women with DMP had twofold higher odds for postpartum depression compared with women without DMP. Although no association was observed between DMP and antepartum depression, DMP was associated with higher antepartum depression scores.

Conclusions 

Our study shows an association between DMP and PND, which might be considered a risk factor when screening for high-risk groups.

sted, utgiver, år, opplag, sider
Wolters Kluwer, 2024
Emneord
diabetes mellitus in pregnancy, gestational diabetes, pregestational diabetes, perinatal depression, antepartum depression, postpartum depression, BASIC, Biology, Affect, Stress, Imaging, Cognition, BMI, body mass index, CI, confidence interval, DMP, diabetes mellitus in pregnancy, EPDS, Edinburgh Postnatal Depression Scale, ICD, International Classification of Diseases, OR, odds ratio, PND, perinatal depression, RR, relative risk
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-521835 (URN)10.1097/PSY.0000000000001261 (DOI)001124019500001 ()37994519 (PubMedID)
Forskningsfinansiär
Swedish Research Council, 523-2014-2342Swedish Research Council, 523-2014-07605
Tilgjengelig fra: 2024-01-29 Laget: 2024-01-29 Sist oppdatert: 2024-01-29bibliografisk kontrollert
Radmark, L., Osika, W., Wallen, M. B., Nissen, E., Lönnberg, G., Branstrom, R., . . . Niemi, M. (2023). Autonomic function and inflammation in pregnant women participating in a randomized controlled study of Mindfulness Based Childbirth and Parenting. BMC Pregnancy and Childbirth, 23(1), Article ID 237.
Åpne denne publikasjonen i ny fane eller vindu >>Autonomic function and inflammation in pregnant women participating in a randomized controlled study of Mindfulness Based Childbirth and Parenting
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2023 (engelsk)Inngår i: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 23, nr 1, artikkel-id 237Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Pregnancy and childbirth are significant events in many women's lives, and the prevalence of depressive symptoms increases during this vulnerable period. Apart from well documented cognitive, affective, and somatic symptoms, stress and depression are associated with physiological changes, such as reduced heart-rate variability (HRV) and activation of the inflammatory response system. Mindfulness Based Interventions may potentially have an effect on both HRV, inflammatory biomarkers, and self-assessed mental health. Therefore, the aim of this study was to assess the effects of a Mindfulness Childbirth and Parenting (MBCP) intervention on HRV, serum inflammatory marker levels, through an RCT study design with an active control group. Methods This study is a sub-study of a larger RCT, where significant intervention effects were found on perinatal depression (PND) and perceived stress. Participants were recruited through eight maternity health clinics in Stockholm, Sweden. In this sub-study, we included altogether 80 women with increased risk for PND, and blood samples and HRV measures were available from 60 of the participants (26 in the intervention and 34 in the control group). Results Participants who received MBCP reported a significantly larger reduction in perceived stress and a significantly larger increase in mindfulness, compared to participants who received the active control treatment. However, in this sub-study, the intervention had no significant effect on PND, inflammatory serum markers or measures of HRV. Conclusions No significant differences were found regarding changes in HRV measures and biomarkers of inflammation, larger studies may be needed in the future.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2023
Emneord
Mindfulness, Pregnancy, Depression, Inflammation, Heart rate variability
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-503247 (URN)10.1186/s12884-023-05528-2 (DOI)000968955100002 ()37038176 (PubMedID)
Forskningsfinansiär
Swedish Research Council, 2014-10167
Tilgjengelig fra: 2023-06-14 Laget: 2023-06-14 Sist oppdatert: 2023-06-14bibliografisk kontrollert
Tu, H.-F., Fransson, E., Kunovac Kallak, T., Elofsson, U., Ramklint, M. & Skalkidou, A. (2023). Cohort profile: the U-BIRTH study on peripartum depression and child development in Sweden. BMJ Open, 13(11), Article ID e072839.
Åpne denne publikasjonen i ny fane eller vindu >>Cohort profile: the U-BIRTH study on peripartum depression and child development in Sweden
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2023 (engelsk)Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 13, nr 11, artikkel-id e072839Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: The current U-BIRTH cohort (Uppsala Birth Cohort) extends our previous cohort Biology, Affect, Stress, Imaging and Cognition (BASIC), assessing the development of children up to 11 years after birth. The U-BIRTH study aims to (1) assess the impact of exposure to peripartum mental illness on the children's development taking into account biological and environmental factors during intrauterine life and childhood; (2) identify early predictors of child neurodevelopmental and psychological problems using biophysiological, psychosocial and environmental variables available during pregnancy and early post partum.

Participants: All mothers participating in the previous BASIC cohort are invited, and mother-child dyads recruited in the U-BIRTH study are consecutively invited to questionnaire assessments and biological sampling when the child is 18 months, 6 years and 11 years old. Data collection at 18 months (n=2882) has been completed. Consent for participation has been obtained from 1946 families of children having reached age 6 and from 698 families of children having reached age 11 years.

Findings to date: Based on the complete data from pregnancy to 18 months post partum, peripartum mental health was significantly associated with the development of attentional control and gaze-following behaviours, which are critical to cognitive and social learning later in life. Moreover, infants of depressed mothers had an elevated risk of difficult temperament and behavioural problems compared with infants of non-depressed mothers. Analyses of biological samples showed that peripartum depression and anxiety were related to DNA methylation differences in infants. However, there were no methylation differences in relation to infants' behavioural problems at 18 months of age.

Future Plans: Given that the data collection at 18 months is complete, analyses are now being undertaken. Currently, assessments for children reaching 6 and 11 years are ongoing.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2023
Emneord
Community child health, Depression & mood disorders, GYNAECOLOGY, PSYCHIATRY
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-517881 (URN)10.1136/bmjopen-2023-072839 (DOI)37949626 (PubMedID)
Forskningsfinansiär
Region Uppsala, ALF-965886Region Uppsala, ALF-965905Marianne and Marcus Wallenberg Foundation, MMW2011.0115Göran Gustafsson Foundation for promotion of scientific research at Uppala University and Royal Institute of Technology, 1551 A-2015Swedish Research Council, 523-2014-07605Gillbergska stiftelsen, 2022
Tilgjengelig fra: 2023-12-14 Laget: 2023-12-14 Sist oppdatert: 2024-01-26bibliografisk kontrollert
Gudnadottir, U., Du, J., Hugerth, L. W. W., Engstrand, L., Schuppe-Koistinen, I., Itzel, E. W., . . . Brusselaers, N. (2023). Pre-pregnancy complications-associated factors and wellbeing in early pregnancy: a Swedish cohort study. BMC Pregnancy and Childbirth, 23, Article ID 153.
Åpne denne publikasjonen i ny fane eller vindu >>Pre-pregnancy complications-associated factors and wellbeing in early pregnancy: a Swedish cohort study
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2023 (engelsk)Inngår i: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 23, artikkel-id 153Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more than one year, or the use of artificial reproductive technologies. We aim to identify factors associated with pre-pregnancy complications and poor well-being in early pregnancy.

Methods: Online questionnaire data from 5330 unique pregnancies in Sweden were collected from November 2017 - February 2021. Multivariable logistic regression modelling was used to investigate potential risk factors for pre-pregnancy complications and differences in early pregnancy symptoms.

Results: Pre-pregnancy complications were identified in 1142 participants (21%). Risk factors included diagnosed endometriosis, thyroid medication, opioids and other strong pain medication, body mass index > 25 kg/m(2) and age over 35 years. Different subgroups of pre-pregnancy complications had unique risk factors. The groups also experienced different pregnancy symptoms in early pregnancy, where women that had experienced recurrent pregnancy loss were at higher risk of depression in their current pregnancy.

Conclusion: We report one of the largest pregnancy cohorts with high frequency of pre-pregnancy complications compared to the Swedish population. Prescribed drug use and body weight were the top potentially modifiable risk factors in all groups. Participants that experienced pre-pregnancy complications also had higher risk of depression and pregnancy problems in early pregnancy.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2023
Emneord
Artificial reproductive technologies, Early pregnancy, Fertility, Recurrent pregnancy loss, Subfertility, Late miscarriage, Pregnancy symptoms, Pre-pregnancy
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-499931 (URN)10.1186/s12884-023-05479-8 (DOI)000945790900007 ()36890460 (PubMedID)
Tilgjengelig fra: 2023-04-06 Laget: 2023-04-06 Sist oppdatert: 2023-04-06bibliografisk kontrollert
Lager, S., Gidén, K., Axfors, C., Sigvardsson, F., Kollia, N., Nylander, I., . . . Skalkidou, A. (2022). Alcohol consumption habits and associations with anxiety or depressive symptoms postpartum in women with high socioeconomic status in Sweden.. Archives of Women's Mental Health
Åpne denne publikasjonen i ny fane eller vindu >>Alcohol consumption habits and associations with anxiety or depressive symptoms postpartum in women with high socioeconomic status in Sweden.
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2022 (engelsk)Inngår i: Archives of Women's Mental Health, ISSN 1434-1816, E-ISSN 1435-1102Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Postpar tum depression and anxiety are common among new mothers. It is well-established that in the general population alcohol use is associated with depression and anxiety. Linking alcohol consumption to symptoms of postpartum depression (PPDS) or postpartum anxiety (PPAS) is presently less established. This study aims to determine if alcohol consumption pre-pregnancy, 6 weeks postpartum, 6 months postpartum, or changes in alcohol consumption are associated with PPDS or PPAS. Longitudinal data on 3849 women from a Swedish perinatal cohort were analyzed using logistic regression analyses for associations between alcohol consumption and symptoms of anxiety or depression, as assessed with the Edinburgh Postnatal Depression Scale. There was no association between pre-pregnancy drinking habits and PPDS (p = 0.588, n = 2479) or PPAS (p = 0.942; n = 2449) at 6 weeks postpartum. Similarly, no associations were observed between concurrent drinking habits at 6 weeks postpartum and PPAS (p = 0.070, n = 3626), 6 months postpartum and PPDS (0.647, n = 3461) or PPAS (p = 0.700, n = 3431). However, there was an association between drinking habits at 6 weeks postpartum and concurrent PPDS (p = 0.047, n = 3659). In conclusion, robust associations were not found between postpartum alcohol consumption and mood symptoms. This lack of association between poor mental health and risk behaviors in new mothers could be interpreted as a result of long-term policy work and high participation in Swedish maternity care. Future studies need to address these research questions in more diverse socio-cultural contexts.

sted, utgiver, år, opplag, sider
Springer Nature, 2022
Emneord
Alcohol drinking, Anxiety, Depression, Mothers, Postpartum, Pregnancy
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-485758 (URN)10.1007/s00737-022-01268-y (DOI)000859641000001 ()36161365 (PubMedID)
Tilgjengelig fra: 2022-09-28 Laget: 2022-09-28 Sist oppdatert: 2022-10-20bibliografisk kontrollert
Fransson, E., Gudnadottir, U., Hugerth, L. W., Itzel, E. W., Hamsten, M., Boulund, F., . . . Engstrand, L. (2022). Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events. BMJ Open, 12(10), Article ID e065825.
Åpne denne publikasjonen i ny fane eller vindu >>Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events
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2022 (engelsk)Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 12, nr 10, artikkel-id e065825Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose The Swedish Maternal Microbiome (SweMaMi) project was initiated to better understand the dynamics of the microbiome in pregnancy, with longitudinal microbiome sampling, shotgun metagenomics, extensive questionnaires and health registry linkage. Participants Pregnant women were recruited before the 20th gestational week during 2017-2021 in Sweden. In total, 5439 pregnancies (5193 unique women) were included. For 3973 pregnancies (73%), samples were provided at baseline, and for 3141 (58%) at all three timepoints (second and third trimester and postpartum). In total, 38 591 maternal microbiome samples (vaginal, faecal and saliva) and 3109 infant faecal samples were collected. Questionnaires were used to collect information on general, reproductive and mental health, diet and lifestyle, complemented by linkage to the nationwide health registries, also used to follow up the health of the offspring (up to age 10). Findings to date The cohort is fairly representative for the total Swedish pregnant population (data from 2019), with 41% first-time mothers. Women with university level education, born in Sweden, with normal body mass index, not using tobacco-products and aged 30-34 years were slightly over-represented. Future plans The sample and data collection were finalised in November 2021. The next steps are the characterisation of the microbial DNA and linkage to the health and demographic information from the questionnaires and registries. The role of the microbiome on maternal and neonatal outcomes and early-childhood diseases will be explored (including preterm birth, miscarriage) and the role and interaction of other risk factors and confounders (including endometriosis, polycystic ovarian syndrome, diet, drug use). This is currently among the largest pregnancy cohorts in the world with longitudinal design and detailed and standardised microbiome sampling enabling follow-up of both mothers and children. The findings are expected to contribute greatly to the field of reproductive health focusing on pregnancy and neonatal outcomes.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2022
Emneord
fetal medicine, maternal medicine, bacteriology, microbiology, public health
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-488555 (URN)10.1136/bmjopen-2022-065825 (DOI)000874855700019 ()36288838 (PubMedID)
Tilgjengelig fra: 2022-11-18 Laget: 2022-11-18 Sist oppdatert: 2023-08-28bibliografisk kontrollert
Fransson, E., Karalexi, M., Kimmel, M. C., Bränn, E., Kollia, N., Tas, A., . . . Papadopoulos, F. (2022). Differentiated mental health patterns in pregnancy during COVID-19 first two waves in Sweden: a mixed methods study using digital phenotyping. Scientific Reports, 12(1), Article ID 21253.
Åpne denne publikasjonen i ny fane eller vindu >>Differentiated mental health patterns in pregnancy during COVID-19 first two waves in Sweden: a mixed methods study using digital phenotyping
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2022 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 12, nr 1, artikkel-id 21253Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

To utilize modern tools to assess depressive and anxiety symptoms, wellbeing and life conditions in pregnant women during the first two waves of the COVID-19 pandemic in Sweden. Pregnant women (n = 1577) were recruited through the mobile application Mom2B. Symptoms of depression, anxiety and wellbeing were assessed during January 2020–February 2021. Movement data was collected using the phone’s sensor. Data on Google search volumes for “Corona” and Covid-related deaths were obtained. Qualitative analysis of free text responses regarding maternity care was performed. Two peaks were seen for depressive symptoms, corresponding to the two waves. Higher prevalence of anxiety was only noted during the first wave. A moderating effect of the two waves in the association of depression, anxiety, and well-being with Covid deaths was noted; positive associations during the first wave and attenuated or became negative during the second wave. Throughout, women reported on cancelled healthcare appointments and worry about partners not being allowed in hospital. The association of mental health outcomes with relevant covariates may vary during the different phases in a pandemic, possibly due to adaptation strategies on a personal and societal/healthcare level. Digital phenotyping can help healthcare providers and governmental bodies to in real time monitor high-risk groups during crises, and to adjust the support offered.

sted, utgiver, år, opplag, sider
Springer Nature, 2022
HSV kategori
Forskningsprogram
Psykiatri; Epidemiologi
Identifikatorer
urn:nbn:se:uu:diva-493227 (URN)10.1038/s41598-022-25107-3 (DOI)000992275200017 ()36481663 (PubMedID)
Forskningsfinansiär
Swedish Association of Local Authorities and RegionsSwedish Research Council, 523-2014-2342Swedish Research Council, 2020-01965Uppsala UniversityFredrik och Ingrid Thurings Stiftelse
Tilgjengelig fra: 2023-01-12 Laget: 2023-01-12 Sist oppdatert: 2023-06-20bibliografisk kontrollert
Bränn, E., Skalkidou, A., Schwartz, J., Papadopoulos, F., Sundström Poromaa, I. & Fransson, E. (2022). Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups. Brain, Behavior, & Immunity - Health, 22, Article ID 100468.
Åpne denne publikasjonen i ny fane eller vindu >>Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups
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2022 (engelsk)Inngår i: Brain, Behavior, & Immunity - Health, E-ISSN 2666-3546, Vol. 22, artikkel-id 100468Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective

Mechanisms driving temporal fluctuations of inflammatory markers during pregnancy, and how these might differ between distinct perinatal depressive trajectories, are not well understood. The aim of this study was to investigate cytokines levels over the course of pregnancy in women with different trajectories of depressive symptoms peripartum, and relate the levels to levels of non-pregnant controls.

Methods

Based on the Edinburgh Postnatal Depression Scale and/or selective serotonin reuptake inhibitors use, 131 women were categorized into: no (n = 65); antepartum (APD, n = 19), postpartum (PPD, n = 17) and persistent (n = 30) depressive symptoms. Plasma samples (n = 386) were analyzed for levels of interleukin (IL)-8, IL-18, Tumor necrosis factor-α, macrophage colony-stimulating factor (M-CSF), vascular endothelial growth factor A (VEGF-A) and fractalkine, at four different time-points (twice during pregnancy, during childbirth, and postpartum) using Bio-Plex Pro Human Cytokine Assays. Generalized linear mixed models were applied to analyze the associations between cytokine levels, time-point, perinatal depressive symptom trajectory group and their interaction.

Results

For all markers but VEGF-A, pregnancy was associated with higher cytokine levels compared to the non-pregnant controls, with delivery being the most prominent time-point. For M-CSF, IL-18 and VEGF-A, levels were back to the non-pregnant status at postpartum week 8. An effect of perinatal depressive symptom trajectory groups on cytokine levels was found for VEGF-A. Women with PPD and women with APD had lower levels of VEGF-A throughout the study period compared to women with persistent depression, and women with PPD had lower levels compared to non-depressed women.

Conclusions

Lower levels of VEGF-A were noted among women in some trajectories of depressive symptoms peripartum. The peripartum period is a time of tremendous immune system adaptations. Standardization of time-points for cytokine measurements in studies of perinatal depression are important in order to draw valid conclusions on the role of the immune system in perinatal depression.

sted, utgiver, år, opplag, sider
Elsevier, 2022
Emneord
APD, Antepartum depressive symptoms, Depression, EPDS, Edinburgh Postnatal Depression Scale, IL, Interleukin, Immune response, M-CSF, Macrophage colony-stimulating factor, PPD, Postpartum depressive symptoms, Pregnancy, Psychoneuroimmunology, TNF, Tumor necrosis factor, VEGF-A, Vascular endothelial growth factor A
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-450036 (URN)10.1016/j.bbih.2022.100468 (DOI)001062924700012 ()35571146 (PubMedID)
Forskningsfinansiär
Magnus Bergvall Foundation, 2017–02165Swedish Research Council, 521-2013–2339Swedish Research Council, 523-2014-2342Marianne and Marcus Wallenberg Foundation, (MMW2011.0115
Tilgjengelig fra: 2021-08-10 Laget: 2021-08-10 Sist oppdatert: 2024-01-25bibliografisk kontrollert
Kunovac Kallak, T., Fransson, E., Bränn, E., Berglund, H., Lager, S., Comasco, E., . . . Skalkidou, A. (2022). Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study. Translational Psychiatry, 12, Article ID 186.
Åpne denne publikasjonen i ny fane eller vindu >>Maternal prenatal depressive symptoms and toddler behavior: an umbilical cord blood epigenome-wide association study
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2022 (engelsk)Inngår i: Translational Psychiatry, E-ISSN 2158-3188, Vol. 12, artikkel-id 186Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Children of mothers with prenatal depressive symptoms (PND) have a higher risk of behavioral problems; fetal programming through DNA methylation is a possible underlying mechanism. This study investigated DNA methylation in cord blood to identify possible "at birth" signatures that may indicate susceptibility to behavioral problems at 18 months of age. Cord blood was collected from 256 children of mothers who had self-reported on symptoms of depression during pregnancy and the behavior of their child at 18 months of age. Whole genome DNA methylation was assessed using Illumina MethylationEPIC assay. The mother and child pairs were categorized into four groups, based on both self-reported depressive symptoms, PND or Healthy control (HC), and scores from the Child Behavior checklist (high or low for internalizing, externalizing, and total scores). Adjustments were made for batch effects, cell-type, and clinical covariates. Differentially methylated sites were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p values < 0.05 were considered significant. The analysis was also stratified by sex of the child. Among boys, we observed higher and correlated DNA methylation of one CpG-site in the promoter region of TPP1 in the HC group, with high externalizing scores compared to HC with low externalizing scores. Boys in the PND group showed lower DNA methylation in NUDT15 among those with high, compared to low, internalizing scores; the DNA methylation levels of CpGs in this gene were positively correlated with the CBCL scores. Hence, the differentially methylated CpG sites could be of interest for resilience, regardless of maternal mental health during pregnancy. The findings are in a relatively healthy study cohort, thus limiting the possibility of detecting strong effects associated with behavioral difficulties. This is the first investigation of cord blood DNA methylation signs of fetal programming of PND on child behavior at 18 months of age and thus calls for independent replications.

sted, utgiver, år, opplag, sider
Springer NatureSpringer Nature, 2022
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-474707 (URN)10.1038/s41398-022-01954-6 (DOI)000791331900001 ()35513368 (PubMedID)
Merknad

De två första författarna delar förstaförfattarskapet.

Tilgjengelig fra: 2022-05-23 Laget: 2022-05-23 Sist oppdatert: 2024-01-17bibliografisk kontrollert
Kimmel, M. C., Jin, W., Xia, K., Lun, K., Azcarate-Peril, A., Plantinga, A., . . . Knickmeyer, R. (2022). Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition. Behavioural Brain Research, 418, Article ID 113635.
Åpne denne publikasjonen i ny fane eller vindu >>Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition
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2022 (engelsk)Inngår i: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 418, artikkel-id 113635Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Depression and anxiety during pregnancy and postpartum are common, but affected women differ in timing, trajectories, and extent of symptoms. The objective of this pilot, feasibility study is to analyze trajectories of serotonin and tryptophan-related metabolites, bile acid metabolites, and microbial composition, in relation to psychiatric history and current symptoms across the perinatal period. Serum and fecal samples were collected from 30 women at three times points in the perinatal period and assayed with LC-MS/MS and 16S sequencing respectively. We defined mean trajectories for each metabolite, clustered individuals by metabolite trajectories, tested associations between metabolites, and examined metabolite levels in relation to microbial composition. Findings of note include: (1) changes in kynurenine and the ratio of kynurenic acid to kynurenine from second trimester to third trimester were strongly associated with baseline primary and secondary bile acids. (2) Secondary bile acid UDCA and its conjugated forms were associated with lower bacterial diversity and levels of Lachnospiraceae, a taxa known to produce Short Chain Fatty Acids. (3) History of anxiety was associated with UDCA levels, but history of major depression was not associated with any of the bile acids. (4) There was a trend towards lower dietary fiber for those with history of anxiety or depression. Overall, our results reveal substantial temporal variation in tryptophan-related metabolites and in bile acid metabolites over the perinatal period, with marked inter-individual variability. Trajectories of TRP -related metabolites, primary and secondary bile acids, and the absence or presence of microbes that produce Short Chain Fatty Acids (SCFAs) considered in concert have the potential to differentiate individuals based on perinatal adaptations that may impact mental and overall health.

sted, utgiver, år, opplag, sider
ElsevierElsevier BV, 2022
Emneord
Anxiety, Bile acids, Depression, Microbiome, Perinatal, Tryptophan
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-459958 (URN)10.1016/j.bbr.2021.113635 (DOI)000718888000013 ()34755640 (PubMedID)
Merknad

Emma Fransson and Rebecca Knickmeyer are served equally as mentors on this project

Tilgjengelig fra: 2021-11-30 Laget: 2021-11-30 Sist oppdatert: 2024-01-15bibliografisk kontrollert
Prosjekter
Rätt stöd i rätt tid - test av nya metoder för att mäta risk för depression under graviditet och efter barnafödande [2023-01928_VR]; Uppsala universitet
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-9010-8522