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Khalifa, S. A. M., Elashal, M., Kieliszek, M., Ghazala, N. E., Farag, M. A., Saeed, A., . . . El-Seedi, H. R. (2020). Recent insights into chemical and pharmacological studies of bee bread. Trends in Food Science & Technology, 97, 300-316
Öppna denna publikation i ny flik eller fönster >>Recent insights into chemical and pharmacological studies of bee bread
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2020 (Engelska)Ingår i: Trends in Food Science & Technology, ISSN 0924-2244, E-ISSN 1879-3053, Vol. 97, s. 300-316Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Background: Bee bread is a product of the fermentation of a mixture of pollen, nectar and bee saliva that is inoculated by a wide range of bacteria and yeasts necessary for fermentation after storage in comb cells. Bee bread is regarded as the chief protein resource that bees can utilize, especially for feeding of larvae and adults. Since ancient times, bee bread has been used in different cultures for several nutritional and therapeutic purposes. Scope and approach: In this review, we attempt to highlight the possible biological activities, chemical components, methods of isolation and structure of bee bread in addition to its food supplement value and/or medical applications. Key findings and conclusions: Bee bread has been shown to exhibit antimicrobial, antioxidant, antiradical, anticancer, and anti-inflammatory activities. The basic chemical components of bee bread include carbohydrates, proteins and vitamins, as well as minerals, fatty acids and other substances such as enzymes, natural antibiotics, antioxidants and hormones. Bee bread is considered to be a beneficial food supplement. In recent years, there has been significant interest in the use of bee bread to treat many illnesses.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE LONDON, 2020
Nyckelord
Bee bread, Bee pollen, Flavonoids, Antioxidant, Antimicrobial, Hypolipidaemic, Hepatoprotective, Nutritional values, Food preservation
Nationell ämneskategori
Livsmedelsvetenskap
Identifikatorer
urn:nbn:se:uu:diva-408006 (URN)10.1016/j.tifs.2019.08.021 (DOI)000517848300025 ()
Forskningsfinansiär
Vetenskapsrådet, 2016-05908
Tillgänglig från: 2020-04-02 Skapad: 2020-04-02 Senast uppdaterad: 2020-04-02Bibliografiskt granskad
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., . . . El-Seedi, H. (2019). Marine Natural Products: A Source of Novel Anticancer Drugs. Marine Drugs, 17(9), Article ID 491.
Öppna denna publikation i ny flik eller fönster >>Marine Natural Products: A Source of Novel Anticancer Drugs
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2019 (Engelska)Ingår i: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 17, nr 9, artikel-id 491Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Ort, förlag, år, upplaga, sidor
MDPI, 2019
Nyckelord
marine, plants, microorganism, antitumor, anticancer, cytotoxic, clinical trials, drugs
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
urn:nbn:se:uu:diva-395919 (URN)10.3390/md17090491 (DOI)000487959700017 ()31443597 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2016-05885
Tillgänglig från: 2019-10-30 Skapad: 2019-10-30 Senast uppdaterad: 2019-10-30Bibliografiskt granskad
Mohotti, S., Rajendran, S., Muhammad, T., Strömstedt, A. A., Adhikari, A., Burman, R., . . . Gunasekera, S. (2019). Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens. Journal of Ethnopharmacology, 246, Article ID 112158.
Öppna denna publikation i ny flik eller fönster >>Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
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2019 (Engelska)Ingår i: Journal of Ethnopharmacology, ISSN 0378-8741, E-ISSN 1872-7573, Vol. 246, artikel-id 112158Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Ethnopharmacological relevance: Sri Lanka is known to have very diverse flora. Many of these species are used for plant-based remedies, which form the integral part of two Sri Lankan systems of traditional medicine, Ayurveda and Deshiya Chikitsa. Despite their widespread use, only a limited number of studies have probed into the scientific evidence for bioactivity of these medicinal plants. Such studies rarely progress to the identification of bioactive natural products. Aim of the study: The primary aim was to develop a bioactivity screening method and apply it to 50 Sri Lankan medicinal plants where antimicrobial properties could be relevant for its traditional use. The subsequent aim was the progression into defining and characterising potent isolates within targeted compound classes from such plants, i.e. Derris scandens and its antimicrobial flavonoids. Material and methods: The plant collection comprised 24 species of Fabaceae, 15 Rubiaceae, 7 Solanaceae and 4 Cucurbitaceae plants. These 50 species were collected based on their ethnopharmacological importance and use in Sri Lankan traditional medicine. Crude extracts from each species were initially subjected to radial disc diffusion and microdilution assays. Subsequently, aqueous extracts of all plants were microfractionated in deep well plates using reversed-phase HPLC. Fractions were tested for antibacterial and cytotoxic activities and masses of target bioactive compounds were identified using mass spectrometry. Bioactive compounds with the masses identified through microfractions were isolated from Derris scandens using reversed-phase HPLC. The isolated pure compounds were characterised using LC-MS and NMR. Results: Crude aqueous extracts from 19 species showed activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) in the radial disc diffusion assay. Crude aqueous extracts from 34 plant species and organic extracts from 46 plant species were active against S. aureus (<= 4 mg mL(-1)) in the microdilution assay. Microfractionation demonstrated antibacterial activity for 19 plants and cytotoxicity for 6 plants. Furthermore, target bioactive compounds and their molecular ions were identified during microfractionation. Dalpanitin and vicenin-3, two of the flavonoids isolated from Derris scandens gave MICs of 23 mu g mL(-1) against S. aureus. Dalpanitin also exhibited relevant MICs on Gram-negative bacteria (94 mu g mL(-1)) against Escherichia coli and Pseudomonas aeruginosa). Conclusion: The microfractionation protocol developed in this study enabled time-efficient screening of many plants species, using a small quantity of sample material. In addition, microfractionation served as a guiding tool for identifying individual antimicrobial compounds. Through this process, flavonoids were isolated from Derris scandens, out of which dalpanitin and vicenin-3 showed activity in the low micromolar range. The high hit rate for in vitro antibacterial properties from this ethnopharmacologically guided sample collection gives credence to Sri Lankan traditional herbal medicine as a source for drug discovery.

Nyckelord
Sri Lanka, Medicinal plants, Microfractionation, Antimicrobial activity, Cytotoxicity, Flavonoids
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
urn:nbn:se:uu:diva-397136 (URN)10.1016/j.jep.2019.112158 (DOI)000493211800010 ()31421182 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2013-06672
Tillgänglig från: 2019-11-28 Skapad: 2019-11-28 Senast uppdaterad: 2019-11-28Bibliografiskt granskad
Göransson, U., Jacobsson, E., Strand, M. & Andersson, H. S. (2019). The Toxins of Nemertean Worms. Toxins, 11(2), Article ID 120.
Öppna denna publikation i ny flik eller fönster >>The Toxins of Nemertean Worms
2019 (Engelska)Ingår i: Toxins, ISSN 2072-6651, E-ISSN 2072-6651, Vol. 11, nr 2, artikel-id 120Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Most ribbon worms (phylum: Nemertea) are found in marine environments, where they act as predators and scavengers. They are characterized by an eversible proboscis that is used to hunt for prey and thick mucus covering their skin. Both proboscis and epidermal mucus mediate toxicity to predators and preys. Research into the chemical nature of the substances that render toxicity has not been extensive, but it has nevertheless led to the identification of several compounds of potential medicinal use or for application in biotechnology. This review provides a complete account of the current status of research into nemertean toxins.

Ort, förlag, år, upplaga, sidor
MDPI, 2019
Nyckelord
Anabaseine, cytotoxin, DMXBA, nemertea, nemertide, parborlysin, ribbon worm, tetrodotoxin
Nationell ämneskategori
Zoologi
Identifikatorer
urn:nbn:se:uu:diva-380672 (URN)10.3390/toxins11020120 (DOI)000460801500062 ()30781381 (PubMedID)
Forskningsfinansiär
Forskningsrådet Formas, 2018-00613Vetenskapsrådet, 214-3327; 2018-005403Crafoordska stiftelsen, 20160810
Tillgänglig från: 2019-04-01 Skapad: 2019-04-01 Senast uppdaterad: 2019-04-01Bibliografiskt granskad
Gunasekera, S., Muhammad, T., Strömstedt, A. A., Rosengren, K. J. & Göransson, U. (2018). Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity. ChemBioChem (Print), 19(9), 931-939
Öppna denna publikation i ny flik eller fönster >>Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity
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2018 (Engelska)Ingår i: ChemBioChem (Print), ISSN 1439-4227, E-ISSN 1439-7633, Vol. 19, nr 9, s. 931-939Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The human host defence peptide LL-37 is a broad-spectrum antibiotic with immunomodulatory functions. Residues 18-29 in LL-37 have previously been identified as a minimal peptide (KR-12) that retains antibacterial activity with decreased cytotoxicity. In this study, analogues of KR-12 were generated by Ala and Lys scans to identify key elements for activity. These were tested against a panel of human pathogens and for membrane permeabilisation on liposomes. Replacements of hydrophobic and cationic residues with Ala were detrimental for antibiotic potency. Substitutions by Lys increased activity, as long as the increase in cationic density did not disrupt the amphiphilic disposition of the helical structure. Importantly, substitutions showed differential effects against different organisms. Replacement of Gln5 with Lys and Asp9 with Ala or Lys improved the broad-spectrum activity most, each resulting in up to an eightfold increase in potency against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The improved analogues displayed no significant toxicity against human cells, and thus, KR-12 is a tuneable template for antibiotic development.

Ort, förlag, år, upplaga, sidor
WILEY-V C H VERLAG GMBH, 2018
Nyckelord
antibiotics, cytotoxicity, drug discovery, peptides, structure-activity relationships
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
urn:nbn:se:uu:diva-356391 (URN)10.1002/cbic.201700599 (DOI)000431625100008 ()29430821 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2011-3403Carl Tryggers stiftelse för vetenskaplig forskning , CTS 10: 126Carl Tryggers stiftelse för vetenskaplig forskning , CTS 11: 169Svenska läkaresällskapet, SLS-254511
Tillgänglig från: 2018-07-25 Skapad: 2018-07-25 Senast uppdaterad: 2020-02-18Bibliografiskt granskad
Slazak, B., Kapusta, M., Strömstedt, A. A., Slomka, A., Krychowiak, M., Shariatgorji, M., . . . Göransson, U. (2018). How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System. Frontiers in Plant Science, 9, Article ID 1296.
Öppna denna publikation i ny flik eller fönster >>How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System
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2018 (Engelska)Ingår i: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 9, artikel-id 1296Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Cyclotides are cyclic plant polypeptides of 27-37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them. The anti-insect larvae effects of kB1 and antibacterial activity of cyO2 suggest that cyclotides are a part of plant host defense. The sweet violet (Viola odorata L.) produces a wide array of cyclotides, including kB1 (kalata B1) and cyO2 (cycloviolacin O2), with distinct presumed biological roles. Here, we evaluate V. odorata cyclotides' potency against plant pathogens and their mode of action using bioassays, liposome experiments and immunogold labeling for transmission electron microscopy (TEM). We explore the link between the biological activity and distribution in plant generative, vegetative tissues and seeds, depicted by immunohistochemistry and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Cyclotides cyO2, cyO3, cyO13, and cyO19 are shown to have potent activity against model fungal plant pathogens (Fusarium oxysporum, F. graminearum, F. culmorum, Mycosphaerella fragariae, Botrytis cinerea) and fungi isolated from violets (Colletotrichum utrechtense and Alternaria alternata), with minimal inhibitory concentrations (MICs) ranging from 0.8 to 25 mu M. Inhibition of phytopathogenic bacteria - Pseudomonas syringae pv. syringae, Dickeya dadantii and Pectobacterium atrosepticum - is also observed with MIC = 25-100 mu M. A membrane-disrupting antifungal mode of action is shown. Finding cyO2 inside the fungal spore cells in TEM images may indicate that other, intracellular targets may be involved in the mechanism of toxicity. Fungi can not break down cyclotides in the course of days. varv A (kalata S) and kB1 show little potency against pathogenic fungi when compared with the tested cycloviolacins. cyO2, cyO3, cyO19 and kB1 are differentially distributed and found in tissues vulnerable to pathogen (epidermis, rizodermis, vascular bundles, protodermis, procambium, ovary walls, outer integuments) and pest ( ground tissues of leaf and petiole) attacks, respectively, indicating a link between the cyclotides' sites of accumulation and biological role. Cyclotides emerge as a comprehensive defense system in V. odorata, in which different types of peptides have specific targets that determine their distribution in plant tissues.

Ort, förlag, år, upplaga, sidor
FRONTIERS MEDIA SA, 2018
Nyckelord
cyclotides, plant host defense, Violaceae, antimicrobial peptide, antifungal defense, MALDI-MSI, immunohistochemistry
Nationell ämneskategori
Botanik
Identifikatorer
urn:nbn:se:uu:diva-365299 (URN)10.3389/fpls.2018.01296 (DOI)000444243600001 ()30254654 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 621-2007-5167Vetenskapsrådet, 621-2014-6215Stiftelsen för strategisk forskning (SSF), RIF14-0078Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Tillgänglig från: 2018-11-13 Skapad: 2018-11-13 Senast uppdaterad: 2018-11-13Bibliografiskt granskad
Jacobsson, E., Andersson, H. S., Strand, M., Peigneur, S., Eriksson, C., Lodén, H., . . . Göransson, U. (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific Reports, 8, Article ID 4596.
Öppna denna publikation i ny flik eller fönster >>Peptide ion channel toxins from the bootlace worm, the longest animal on Earth
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2018 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikel-id 4596Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the alpha-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the 'bootlace worm' known as the longest animal on earth. The most abundant peptide, the 31-residue long alpha-1, was isolated, synthesized, and its 3D NMR structure determined. Transcriptome analysis including 17 species revealed eight alpha-nemertides, mainly distributed in the genus Lineus. alpha-1 caused paralysis and death in green crabs (Carcinus maenas) at 1 mu g/kg (similar to 300 pmol/kg). It showed profound effect on invertebrate voltage-gated sodium channels (e.g. Blattella germanica Na(v)1) at low nanomolar concentrations. Strong selectivity for insect over human sodium channels indicates that a-nemertides can be promising candidates for development of bioinsecticidal agents.

Ort, förlag, år, upplaga, sidor
NATURE PUBLISHING GROUP, 2018
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
urn:nbn:se:uu:diva-351585 (URN)10.1038/s41598-018-22305-w (DOI)000428029600001 ()29567943 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2014-3327]
Tillgänglig från: 2018-05-29 Skapad: 2018-05-29 Senast uppdaterad: 2019-08-15Bibliografiskt granskad
Wang, Y., Lloyd, K. A., Gunasekera, S., Eriksson, C., Ramsköld, D., Lundberg, K., . . . Grönwall, C. (2018). Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG. Arthritis & Rheumatology, 70
Öppna denna publikation i ny flik eller fönster >>Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG
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2018 (Engelska)Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2018
Nationell ämneskategori
Reumatologi och inflammation
Identifikatorer
urn:nbn:se:uu:diva-369631 (URN)000447268900009 ()
Tillgänglig från: 2018-12-17 Skapad: 2018-12-17 Senast uppdaterad: 2018-12-17Bibliografiskt granskad
Gunasekera, S., Fernandes-Cerqueira, C., Wennmalm, S., Wahamaa, H., Sommarin, Y., Catrina, A. I., . . . Göransson, U. (2018). Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis. ACS Chemical Biology, 13(6), 1525-1535
Öppna denna publikation i ny flik eller fönster >>Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
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2018 (Engelska)Ingår i: ACS Chemical Biology, ISSN 1554-8929, E-ISSN 1554-8937, Vol. 13, nr 6, s. 1525-1535Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope alpha-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.

Ort, förlag, år, upplaga, sidor
AMER CHEMICAL SOC, 2018
Nationell ämneskategori
Reumatologi och inflammation
Identifikatorer
urn:nbn:se:uu:diva-358527 (URN)10.1021/acschembio.8b00118 (DOI)000435746200015 ()29630823 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2012-5063Vetenskapsrådet, 2017-02577Stiftelsen för strategisk forskning (SSF), F06-0058Reumatikerförbundet, R-755861Stockholms läns landsting, 20160378
Tillgänglig från: 2018-09-03 Skapad: 2018-09-03 Senast uppdaterad: 2018-09-03Bibliografiskt granskad
Strömstedt, A. A., Park, S., Burman, R. & Göransson, U. (2017). Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. Biochimica et Biophysica Acta - Biomembranes, 1859(10), 1986-2000
Öppna denna publikation i ny flik eller fönster >>Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
2017 (Engelska)Ingår i: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1859, nr 10, s. 1986-2000Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Cyclotides are a family of plant peptides characterized by a cystine knot embedded in a macrocyclic backbone. They bind to and disrupt phospholipid membranes, which explain their lytic activity on cells. In this study, we expose the full antibacterial potency of cyclotides by avoiding its inhibition by rich growth media assay conditions. For that purpose a two-step microdilution assay protocol was developed, using non-growing conditions during initial peptide incubation. A diverse set of cyclotides was tested for antibacterial and antifungal activity, and the results show that most cyclotides are active under these conditions, especially against Gram-negative bacteria. Activity was observed at sub-micromolar concentrations for three of the cyclotides tested, surpassing that of the control peptides LL-37 and melittin. Noteworthy, two anionic cyclotides were active on Pseudomonas aeruginosa at low micromolar concentrations. Broad-spectrum activity was pronounced among cycloviolacin cyclotides, which included activity on Staphylococcus aureus and Candida albicans. The factors influencing their bactericidal spectrum were revealed by correlating antimicrobial activity with membrane permeabilization on various liposome systems and with the physiochemical properties of the cyclotides. Whereas general electrostatic and hydrophobic parameters are more important for broad-spectrum cyclotides; a phospholipid-specific mechanism of membrane permeabilization, through interaction with phosphatidylethanolamine-lipids, is essential for cyclotides active primarily on Gram-negative bacteria.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE BV, 2017
Nyckelord
Cyclotide, Antimicrobial peptide, Antibacterial, Membrane permeabilization, Phosphatidylethanolamine-binding, Structure-activity relationship
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
urn:nbn:se:uu:diva-336446 (URN)10.1016/j.bbamem.2017.06.018 (DOI)000411419000024 ()28669767 (PubMedID)
Forskningsfinansiär
Svenska läkaresällskapet, SLS-254511Vetenskapsrådet, 2012-5063
Tillgänglig från: 2017-12-14 Skapad: 2017-12-14 Senast uppdaterad: 2017-12-14Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-5005-9612

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