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Rozental, A., Kottorp, A., Forsstrom, D., Månsson, K. N. .., Boettcher, J., Andersson, G., . . . Carlbring, P. (2019). The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments. Behavioural and Cognitive Psychotherapy, 47(5), 559-572
Öppna denna publikation i ny flik eller fönster >>The Negative Effects Questionnaire: psychometric properties of an instrument for assessing negative effects in psychological treatments
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2019 (Engelska)Ingår i: Behavioural and Cognitive Psychotherapy, ISSN 1352-4658, E-ISSN 1469-1833, Vol. 47, nr 5, s. 559-572Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Psychological treatments provide many benefits for patients with psychiatric disorders, but research also suggests that negative effects might occur from the interventions involved. The Negative Effects Questionnaire (NEQ) has previously been developed as a way of determining the occurrence and characteristics of such incidents, consisting of 32 items and six factors. However, the NEQ has yet to be examined using modern test theory, which could help to improve the understanding of how well the instrument works psychometrically.

Aims: The current study investigated the reliability and validity of the NEQ from both a person and item perspective, establishing goodness-of-fit, item bias, and scale precision.

Method: The NEQ was distributed to 564 patients in five clinical trials at post-treatment. Data were analysed using Rasch analysis, i.e. a modern test theory application.

Results: (1) the NEQ exhibits fairness in testing across sociodemographics, (2) shows comparable validity for a final and condensed scale of 20 instead of 32 items, (3) uses a rating scale that advances monotonically in steps of 0 to 4, and (4) is suitable for monitoring negative effects on an item-level.

Conclusions: The NEQ is proposed as a useful instrument for investigating negative effects in psychological treatments, and its newer shorter format could facilitate its use in clinical and research settings. However, further research is needed to explore the relationship between negative effects and treatment outcome, as well as to test it in more diverse patient populations.

Nyckelord
negative effects, Negative Effects Questionnaire, psychological treatments, Rasch analysis
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-394254 (URN)10.1017/S1352465819000018 (DOI)000483716500006 ()30871650 (PubMedID)
Tillgänglig från: 2019-10-11 Skapad: 2019-10-11 Senast uppdaterad: 2019-10-11Bibliografiskt granskad
Lindner, P., Miloff, A., Fagernäs, S., Andersen, J., Sigeman, M., Andersson, G., . . . Carlbring, P. (2019). Therapist-led and self-led one-session virtual reality exposure therapy for public speaking anxiety with consumer hardware and software: A randomized controlled trial. Journal of Anxiety Disorders, 61, 45-54
Öppna denna publikation i ny flik eller fönster >>Therapist-led and self-led one-session virtual reality exposure therapy for public speaking anxiety with consumer hardware and software: A randomized controlled trial
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2019 (Engelska)Ingår i: Journal of Anxiety Disorders, ISSN 0887-6185, E-ISSN 1873-7897, Vol. 61, s. 45-54Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Public speaking anxiety (PSA) is a common condition which can be treated effectively with exposure therapy. However, inherent difficulties in stimuli presentation and control limits dissemination and the therapeutic potential. Virtual Reality (VR) technology has the potential to resolve these issues and provide a scalable platform for self-help interventions. No previous study has examined whether this can be achieved using the first generation of consumer VR hardware and software. In the current trial, n = 25 + 25 participants were randomized to either one-session therapist-led VR exposure therapy for PSA followed by a four-week internet-administered VR to in-vivo transition program, or a waiting-list. Linear mixed effects modeling revealed significant, large (within Cohen’s d = 1.67) decreases in self-reported PSA. The waiting-list was then given access to an internet-administered, self-led version of the same VR exposure therapy to be conducted at home, followed by the same transition program. Dual-slope mixed effects modeling revealed significant, large (d = 1.35) decreases in self-reported PSA. Results were maintained or improved at six- and twelve-month follow-ups. We show for the first time that low-cost, off-the-shelf consumer VR hardware and software can be used to conduct exposure therapy for PSA, both in the traditional, previously impractical one-session format, and in a novel self-led, at-home format.

Nyckelord
Virtual reality, Exposure therapy, Internet interventions, Social anxiety disorder, Public speaking anxiety, In-vivo
Nationell ämneskategori
Psykologi
Identifikatorer
urn:nbn:se:uu:diva-358454 (URN)10.1016/j.janxdis.2018.07.003 (DOI)000456898000006 ()30054173 (PubMedID)
Anmärkning

Correction in: JOURNAL OF ANXIETY DISORDERS, Volume: 64, Pages: 90-90, DOI: 10.1016/j.janxdis.2019.04.002

Tillgänglig från: 2018-08-29 Skapad: 2018-08-29 Senast uppdaterad: 2019-06-19Bibliografiskt granskad
Månsson, K., Garrett, D., Manzouri, A., Wiegert, S., Furmark, T. & Fischer, H. (2018). Affective Brain Signal Variability Separates Social Anxiety Disorder Patients From Healthy Individuals. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S249-S250
Öppna denna publikation i ny flik eller fönster >>Affective Brain Signal Variability Separates Social Anxiety Disorder Patients From Healthy Individuals
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2018 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S249-S250Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Elsevier, 2018
Nyckelord
Social Anxiety Disorder, BOLD fMRI, Variability
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-359379 (URN)10.1016/j.biopsych.2018.02.644 (DOI)000433001900042 ()
Konferens
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Tillgänglig från: 2018-09-17 Skapad: 2018-09-17 Senast uppdaterad: 2018-09-17Bibliografiskt granskad
Kraus, J., Frick, A., Fischer, H., Howner, K., Fredriksson, M. & Furmark, T. (2018). Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder. Psychiatry Research: Neuroimaging, 280, 56-61
Öppna denna publikation i ny flik eller fönster >>Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
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2018 (Engelska)Ingår i: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 280, s. 56-61Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Nyckelord
Social phobia, Emotional faces, International Affective Picture System, IAPS, fMRI, Fear
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-364125 (URN)10.1016/j.pscychresns.2018.08.012 (DOI)000443824900008 ()30165271 (PubMedID)
Forskningsfinansiär
VetenskapsrådetRiksbankens JubileumsfondRiksbankens JubileumsfondHjärnfonden
Tillgänglig från: 2018-11-05 Skapad: 2018-11-05 Senast uppdaterad: 2018-11-05Bibliografiskt granskad
Frick, A., Engman, J., Wahlstedt, K., Gingnell, M., Fredrikson, M. & Furmark, T. (2018). Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder. BJPsych bulletin, 4(3)
Öppna denna publikation i ny flik eller fönster >>Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder
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2018 (Engelska)Ingår i: BJPsych bulletin, ISSN 2056-4694, E-ISSN 2056-4708, Vol. 4, nr 3Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We aimed to identify biomarkers to guide the decision to add selective serotonin reuptake inhibitors (SSRI) to psychological treatment for social anxiety disorder (SAD). Forty-eight patients with SAD underwent functional magnetic resonance imaging and collection of clinical and demographic variables before treatment with cognitive–behavioural therapy, combined on a double-blind basis with either escitalopram or placebo for 9 weeks. Pre-treatment neural reactivity to aversive faces in the dorsal anterior cingulate cortex (ACC), but not clinical/demographic variables, moderated clinical outcomes. Cross-validated individual-level predictions accurately identified 81% of responders/non-responders. Dorsal ACC reactivity is thus a potential biomarker for SAD treatment selection.

Ort, förlag, år, upplaga, sidor
Cambridges Institutes Press, 2018
Nyckelord
Functional magnetic resonance imaging, anxiety, prediction, selective serotonin reuptake inhibitors, cognitive–behavioural therapy, social phobia
Nationell ämneskategori
Psykologi Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-353596 (URN)10.1192/bjo.2018.15 (DOI)000436933400012 ()29922481 (PubMedID)
Forskningsfinansiär
VetenskapsrådetRiksbankens JubileumsfondHjärnfondenForte, Forskningsrådet för hälsa, arbetsliv och välfärdSvenska Sällskapet för Medicinsk Forskning (SSMF)
Tillgänglig från: 2018-06-14 Skapad: 2018-06-14 Senast uppdaterad: 2018-09-26Bibliografiskt granskad
Motilla Hoppe, J., Frick, A., Åhs, F., Linnman, C., Appel, L., Jonasson, M., . . . Furmark, T. (2018). Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits. Translational Psychiatry, 8(1), 168
Öppna denna publikation i ny flik eller fönster >>Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits
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2018 (Engelska)Ingår i: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 8, nr 1, s. 168-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress and anxiety-related behavior. Alterations in the SP-NK1 system have also been observed in human anxiety disorders, yet little is known about the relation between this system and individual differences in personality traits associated with anxiety propensity and approach-avoidance behavior, including trait anxiety, neuroticism, and extraversion. Exploring this relation could provide important insights into the neurobiological underpinnings of human anxiety and the etiology of anxiety disorders, as anxious traits are associated with increased susceptibility to develop psychopathological conditions. Here we examined the relationship between central NK1 receptor availability and self-rated measures of trait anxiety, neuroticism, and extraversion. The amygdala was chosen as the primary region of interest since this structure has been suggested to mediate the effect of the SP-NK1 system on anxiety. Anxious traits and NK1 receptor availability, determined with positron emission tomography and the radiotracer [11C]GR205171, were measured in 17 healthy individuals. Voxel-wise analyses showed a significant positive correlation between bilateral amygdala NK1 receptor availability and trait anxiety, and a trend in similar direction was observed for neuroticism. Conversely, extraversion was found to be negatively associated with amygdala NK1 receptor availability. Extraversion also correlated negatively with the NK1 measure in the cuneus/precuneus and fusiform gyrus according to exploratory whole-brain analyses. In conclusion, our findings indicate that amygdala NK1 receptor availability is associated with anxiety-related personality traits in healthy subjects, consistent with a modulatory role for the SP-NK1 system in human anxiety.

Nationell ämneskategori
Pedagogik
Identifikatorer
urn:nbn:se:uu:diva-358759 (URN)10.1038/s41398-018-0163-1 (DOI)000443079700001 ()
Tillgänglig från: 2018-08-31 Skapad: 2018-08-31 Senast uppdaterad: 2018-12-10Bibliografiskt granskad
Mansson, K., Wager, T. D., Isacsson, N., Kolbeinsson, O., Andersson, G., Fischer, H. & Furmark, T. (2018). Brain Before Behavior: Temporal Dynamics in the Treatment of Social Anxiety - Neural Changes Occur Early and Precede Clinical Improvement. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), 2018, New York, NY. Biological Psychiatry, 83(9), S130-S131
Öppna denna publikation i ny flik eller fönster >>Brain Before Behavior: Temporal Dynamics in the Treatment of Social Anxiety - Neural Changes Occur Early and Precede Clinical Improvement
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2018 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S130-S131Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Nyckelord
Social Anxiety Disorder, BOLD fMRI, Cognitive Behavior Therapy, Temporal Dynamics, Amygdala
Nationell ämneskategori
Psykologi
Identifikatorer
urn:nbn:se:uu:diva-361430 (URN)000432466300319 ()
Konferens
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), 2018, New York, NY
Tillgänglig från: 2018-12-10 Skapad: 2018-12-10 Senast uppdaterad: 2018-12-10Bibliografiskt granskad
Månsson, K., Lindqvist, D., Yang, L., Wolkowitz, O., Nilsonne, G., Isung, J., . . . Furmark, T. (2018). Can Psychological Treatment Slow Down Cellular Aging in Social Anxiety Disorder?: An Intervention Study Evaluating Changes in Telomere Length and Telomerase Activity. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S351-S352
Öppna denna publikation i ny flik eller fönster >>Can Psychological Treatment Slow Down Cellular Aging in Social Anxiety Disorder?: An Intervention Study Evaluating Changes in Telomere Length and Telomerase Activity
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2018 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S351-S352Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Elsevier, 2018
Nyckelord
Telomerase, Telomere, Social Anxiety Disorder, Cognitive Behavior Therapy, Cellular Aging
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-359378 (URN)10.1016/j.biopsych.2018.02.904 (DOI)000433001900299 ()
Konferens
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Anmärkning

Meeting Abstract: S13

Tillgänglig från: 2018-09-17 Skapad: 2018-09-17 Senast uppdaterad: 2018-09-17Bibliografiskt granskad
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E. & Nilson, K. W. (2018). Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents. Development and psychopathology (Print), 30(2), 449-459
Öppna denna publikation i ny flik eller fönster >>Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents
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2018 (Engelska)Ingår i: Development and psychopathology (Print), ISSN 0954-5794, E-ISSN 1469-2198, Vol. 30, nr 2, s. 449-459Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Social anxiety is one of the most commonly reported mental health problems among adolescents, and it has been suggested that parenting style influences an adolescent's level of anxiety. A context-dependent effect of oxytocin on human social behavior has been proposed; however, research on the oxytocin gene (OXT) has mostly been reported without considering contextual factors. This study investigated the interactions between parenting style and polymorphic variations in the OXT gene in association with social anxiety symptoms in a community sample of adolescents (n = 1,359). Two single nucleotide polymorphisms linked to OXT, rs4813625 and rs2770378, were genotyped. Social anxiety and perceived parenting style were assessed by behavioral questionnaires. In interaction models adjusted for sex, significant interaction effects with parenting style were observed for both variants in relation to social anxiety. The nature of the interactions was in line with the differential susceptibility framework for rs4813625, whereas for rs2770378 the results indicated a diathesis–stress type of interaction. The findings may be interpreted from the perspective of the social salience hypothesis of oxytocin, with rs4813625 affecting social anxiety levels along a perceived unsafe–safe social context dimension.

Nationell ämneskategori
Neurovetenskaper Psykologi
Identifikatorer
urn:nbn:se:uu:diva-323574 (URN)10.1017/S0954579417000967 (DOI)000430924500006 ()28606214 (PubMedID)
Forskningsfinansiär
Fredrik och Ingrid Thurings StiftelseHjärnfonden, F02015-0315Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, FORTE 2015-00897Åke Wibergs Stiftelse, MI5-0239Vetenskapsrådet, VR 2015-00495EU, FP7, Sjunde ramprogrammet, INCA 600398Stiftelsen Söderström - Königska sjukhemmet, SLS-559921
Tillgänglig från: 2017-06-08 Skapad: 2017-06-08 Senast uppdaterad: 2019-04-04Bibliografiskt granskad
Groenewold, N., Bas-Hoogendam, J. M., Amod, A. R., van Velzen, L., Aghajani, M., Filippi, C., . . . van der Wee, N. J. J. (2018). Subcortical Volumes in Social Anxiety Disorder: Preliminary Results From Enigma-Anxiety. Paper presented at 73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY. Biological Psychiatry, 83(9), S247-S248
Öppna denna publikation i ny flik eller fönster >>Subcortical Volumes in Social Anxiety Disorder: Preliminary Results From Enigma-Anxiety
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2018 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 83, nr 9, s. S247-S248Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Elsevier, 2018
Nyckelord
Structural MRI, Social Phobia, Thalamus, Meta-analysis, Harmonized Protocols
Nationell ämneskategori
Psykiatri
Identifikatorer
urn:nbn:se:uu:diva-359376 (URN)10.1016/j.biopsych.2018.02.640 (DOI)000433001900038 ()
Konferens
73rd Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), MAY 10-12, 2017, New York, NY
Forskningsfinansiär
NIH (National Institute of Health), BD2K U54 EB020403
Tillgänglig från: 2018-09-17 Skapad: 2018-09-17 Senast uppdaterad: 2018-09-17Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-6821-9058

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