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Bajic, Dragan
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Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2012). Asymmetric Development of the Hippocampal Region Is Common: A Fetal MR Imaging Study. American Journal of Neuroradiology, 33(3), 513-518
Öppna denna publikation i ny flik eller fönster >>Asymmetric Development of the Hippocampal Region Is Common: A Fetal MR Imaging Study
2012 (Engelska)Ingår i: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 33, nr 3, s. 513-518Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND AND PURPOSE: Hippocampal development is poorly understood. This study evaluated the normal development of the hippocampal region during the fetal period by using MR imaging.

MATERIALS AND METHODS: MR images of 63 fetuses without intracranial pathology were reviewed independently by 2 radiologists with no knowledge of the fetal GA. Three MR images were performed postmortem and 60 in vivo. The progress of hippocampal inversion was analyzed in coronal sections, and the left and right sides of the hippocampal region were compared in every case.

RESULTS: The fetuses in the postmortem examinations were at GWs 17-18 and in the in vivo examinations, at GWs 19-36. The hippocampal sulcus was open, bi- or unilaterally, in 39 fetuses. The oldest was at GW 32. The sulcus was closed at GW 21 at the earliest, unilaterally. In 26/63 fetuses (41%), the deepening or closure of the hippocampal sulcus or hippocampal inversion was asymmetric; in 23 fetuses, the right side developed faster. A shallow collateral sulcus was found earliest at GW 17. A deep collateral sulcus was visible earliest at GW 26 unilaterally, but in all fetuses from GW 31 onward, it was seen bilaterally. The orientation of the collateral sulcus was not related to the GA.

CONCLUSIONS: There are wide individual temporal variations in the development and the inversion process of the hippocampal sulcus as well as in the formation of the collateral sulcus. Asymmetric development is common, and in most of the asymmetric cases, the right hippocampus develops faster.

Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
Radiologi
Identifikatorer
urn:nbn:se:uu:diva-131994 (URN)10.3174/ajnr.A2814 (DOI)000301870300024 ()
Tillgänglig från: 2010-10-12 Skapad: 2010-10-12 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2011). Development of the hippocampal region demonstrated on fetal MRI: A preliminary report. NRJ Digital, 1(12), 555-557
Öppna denna publikation i ny flik eller fönster >>Development of the hippocampal region demonstrated on fetal MRI: A preliminary report
2011 (Engelska)Ingår i: NRJ Digital, ISSN 2239-7493, Vol. 1, nr 12, s. 555-557Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Coronal slices of three fetal MRIs performed post mortem and 37 performed in utero, all without intracranial pathology, was assessed. Progress of the hippocampal inversion was analyzed, the left and right sides were compared and occurrence of the collateral sulcus was revealed. The fetuses in the post mortem examinations were at gestation weeks (GW) 17-18 and in the in utero examinations at GW 19-35. The symmetric development of the hippocampal sulcus was revealed in 26 subjects and asymmetric in 14. The non-ovoid hippocampal formation could be evaluated at GW 24 at earliest and an ovoid hippocampus at GW 29. The collateral sulcus could be recognized at GW 17 in post mortem and at GW 22 in in utero examinations. From GW 29 onwards it was seen in all fetuses and it was symmetric in all but one case. Evaluation of the hippocampi is difficult on fetal MRI, especially in in utero examinations. The hippocampal development is not fulfilled at GW 21 as presumed. There is a wide temporal variation in the development of the hippocampal region, and the developmental process does not progress simultaneously in the right and left side of the same individual.

Nationell ämneskategori
Radiologi och bildbehandling
Identifikatorer
urn:nbn:se:uu:diva-170783 (URN)
Tillgänglig från: 2012-03-13 Skapad: 2012-03-13 Senast uppdaterad: 2012-03-13Bibliografiskt granskad
Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2011). Hippocampal development demonstrated by fetal MRI. Asymmetric development is common.. Paper presented at ECR 2011, Vienna, Austria. Insights into Imaging, 2(Suppl 1), B-831
Öppna denna publikation i ny flik eller fönster >>Hippocampal development demonstrated by fetal MRI. Asymmetric development is common.
2011 (Engelska)Ingår i: Insights into Imaging, Vol. 2, nr Suppl 1, s. B-831-Artikel i tidskrift (Refereegranskat) Published
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-246063 (URN)
Konferens
ECR 2011, Vienna, Austria
Tillgänglig från: 2015-03-02 Skapad: 2015-03-02 Senast uppdaterad: 2015-03-25
Bajic, D., Ewald, U. & Raininko, R. (2010). Hippocampal development at gestation weeks 23 to 36: An ultrasound study on preterm neonates. Neuroradiology, 52(6), 489-494
Öppna denna publikation i ny flik eller fönster >>Hippocampal development at gestation weeks 23 to 36: An ultrasound study on preterm neonates
2010 (Engelska)Ingår i: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 52, nr 6, s. 489-494Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: During fetal development, the hippocampal structures fold around the hippocampal sulcus into the temporal lobe. According to the literature, this inversion should be completed at gestation week (GW) 21. Thereafter, the hippocampal shape should resemble the adult shape. However, incomplete hippocampal inversion (IHI) is found in 19% of the common population. The aim of this study was to study fetal hippocampal development by examining neonates born preterm. METHODS: We analyzed cranial ultrasound examinations, performed as a part of the routine assessment of all preterm infants, over a 3-year period and excluded the infants with brain pathology. The final material consisted of 158 children born <35 GW. A rounded form (the ratio between the horizontal and vertical diameters of the hippocampal body <25 GW and >/=25 GW was statistically highly significant (p < 0.001). The frequency of bilateral IHI was highest in the youngest age group. In the other groups, the left-sided IHI was the most common. CONCLUSION: In about 50% of the neonates, hippocampal inversion is not completed up to GW 24; but from 25 GW onwards, the frequency and laterality of IHI is similar to that in the adult population.

Nyckelord
Fetal development, Ultrasonography, Hippocampus, Premature infants, Gestational age, Malrotation
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-124857 (URN)10.1007/s00234-010-0673-x (DOI)000277790000003 ()20352419 (PubMedID)
Tillgänglig från: 2010-05-06 Skapad: 2010-05-06 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
Raininko, R. & Bajic, D. (2010). "Hippocampal malrotation": no real malrotation and not rare. American Journal of Neuroradiology, 31(4), E39; author reply E40
Öppna denna publikation i ny flik eller fönster >>"Hippocampal malrotation": no real malrotation and not rare
2010 (Engelska)Ingår i: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 31, nr 4, s. E39; author reply E40-Artikel i tidskrift (Refereegranskat) Published
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-124865 (URN)10.3174/ajnr.A2013 (DOI)20075082 (PubMedID)
Tillgänglig från: 2010-05-06 Skapad: 2010-05-06 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
Bajic, D., Kumlien, E., Mattsson, P., Lundberg, S., Wang, C. & Raininko, R. (2009). Incomplete hippocampal inversion-is there a relation to epilepsy?. European Radiology, 19(10), 2544-2550
Öppna denna publikation i ny flik eller fönster >>Incomplete hippocampal inversion-is there a relation to epilepsy?
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2009 (Engelska)Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 19, nr 10, s. 2544-2550Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Incomplete hippocampal inversion (IHI) has been described in patients with epilepsy or severe midline malformations but also in nonepileptic subjects without obvious developmental anomalies. We studied the frequency of IHI in different epilepsy syndromes to evaluate their relationship. Three hundred patients were drawn from the regional epilepsy register. Of these, 99 were excluded because of a disease or condition affecting the temporal lobes or incomplete data. Controls were 150 subjects without epilepsy or obvious intracranial developmental anomalies. The coronal MR images were analysed without knowledge of the clinical data. Among epilepsy patients, 30% had IHI (40 left-sided, 4 right-sided, 16 bilateral). Of controls, 18% had IHI (20 left-sided, 8 bilateral). The difference was statistically significant (P < 0.05). Of temporal lobe epilepsy (TLE) patients, 25% had IHI, which was not a significantly higher frequency than in controls (P = 0.34). There was no correlation between EEG and IHI laterality. A total of 44% of Rolandic epilepsy patients and 57% of cryptogenic generalised epilepsy patients had IHI. The IHI frequency was very high in some epileptic syndromes, but not significantly higher in TLE compared to controls. No causality between TLE and IHI could be found. IHI can be a sign of disturbed cerebral development affecting other parts of the brain, maybe leading to epilepsy.

Nyckelord
Hippocampus, Developmental brain anomalies, MRI, Epilepsy
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-105372 (URN)10.1007/s00330-009-1438-y (DOI)000270268700029 ()19440714 (PubMedID)
Tillgänglig från: 2009-06-03 Skapad: 2009-06-03 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Bajic, D., Wang, C., Kumlien, E., Mattsson, P., Lundberg, S., Eeg-Olofsson, O. & Raininko, R. (2008). Incomplete inversion of the hippocampus: a common developmental anomaly. European Radiology, 18(1), 138-142
Öppna denna publikation i ny flik eller fönster >>Incomplete inversion of the hippocampus: a common developmental anomaly
Visa övriga...
2008 (Engelska)Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 18, nr 1, s. 138-142Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Incomplete inversion of the hippocampus, an imperfect fetal development, has been described in patients with epilepsy or severe midline malformations. We studied this condition in a nonepileptic population without obvious developmental anomalies. We analyzed the coronal MR images of 50 women and 50 men who did not have epilepsy. Twenty of them were healthy volunteers and 80 were patients without obvious intracranial developmental anomalies, intracranial masses, hydrocephalus or any condition affecting the temporal lobes. If the entire hippocampus (the head could not be evaluated) were affected, the incomplete inversion was classified as total, otherwise as partial. Incomplete inversion of the hippocampus was found in 19/100 subjects (9 women, 10 men). It was unilateral, always on the left side, in 13 subjects (4 women, 9 men): 9 were of the total type, 4 were partial. It was bilateral in six subjects (five women, one man): four subjects had total types bilaterally, two had a combination of total and partial types. The collateral sulcus was vertically oriented in all subjects with a deviating hippocampal shape. We conclude that incomplete inversion of the hippocampus is not an unusual morphologic variety in a nonepileptic population without other obvious intracranial developmental anomalies.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-15863 (URN)10.1007/s00330-007-0735-6 (DOI)000252593500016 ()17828540 (PubMedID)
Tillgänglig från: 2008-06-18 Skapad: 2008-06-18 Senast uppdaterad: 2017-12-08Bibliografiskt granskad
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