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2020 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 105, no 11, p. e4112-e4123Article in journal (Refereed) Published
Abstract [en]
Purpose
Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609.
Methods
We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness.
Results
High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype.
Main Conclusions
Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.
Keywords
physical activity, gene-environment interaction, LADA, latent autoimmune diabetes in adults, type 2 diabetes, population-based
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-429000 (URN)10.1210/clinem/dgaa549 (DOI)000584540200031 ()32835373 (PubMedID)
Funder
Swedish Research Council, GA 2018-03035Forte, Swedish Research Council for Health, Working Life and Welfare, GA 2018-00337EU, European Research Council, GA 269045Swedish Diabetes AssociationNovo NordiskSwedish Rheumatism AssociationAFA InsuranceRegion StockholmNIH (National Institute of Health)The Research Council of Norway
2020-12-182020-12-182022-10-31Bibliographically approved