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Eurenius, Karin
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Publications (10 of 14) Show all publications
Maack, H. P., Skalkidou, A., Sjöholm, A., Eurenius-Orre, K., Mulic-Lutvica, A., Wikström, A.-K. & Sundström Poromaa, I. (2019). Maternal body mass index moderates antenatal depression effects on infant birthweight. Scientific Reports, 9, Article ID 6213.
Open this publication in new window or tab >>Maternal body mass index moderates antenatal depression effects on infant birthweight
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2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 6213Article in journal (Refereed) Published
Abstract [en]

Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a large for gestational age (LGA) infant. However, the effect of co-morbid depression has received little attention. This study set out to investigate if maternal body mass index (BMI) in early pregnancy moderates antenatal depression effects on infant birthweight. 3965 pregnant women participated in this longitudinal cohort study, where cases (n = 178) had Edinburgh Postnatal Depression Scale (EPDS) score >= 17 in gestational week 17 or 32, and remaining women (n = 3787) were used as controls. The influence of maternal BMI and antenatal depressive symptoms on standardized birthweight was evaluated by analysis of covariance, with adjustment for relevant confounders. Depressed women with BMI 25.0 kg/m(2) or more gave birth to infants with significantly greater standardized birthweight than non-depressed overweight women, whereas the opposite pattern was noted in normal weight women (BMI by antenatal depressive symptoms interaction; F(1,3839) = 6.32; p = 0.012. The increased birthweight in women with co-prevalent overweight and depressive symptoms was not explained by increased weight gain during the pregnancy. Maternal BMI at the beginning of pregnancy seems to influence the association between antenatal depressive symptoms and infant birthweight, but in opposite directions depending on whether the pregnant women is normal weight or overweight. Further studies are needed to confirm our finding.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP, 2019
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-383196 (URN)10.1038/s41598-019-42360-1 (DOI)000464988500025 ()30996270 (PubMedID)
Available from: 2019-07-23 Created: 2019-07-23 Last updated: 2019-07-23Bibliographically approved
Belachew, J., Eurenius, K., Mulic-Lutvica, A. & Axelsson, O. (2017). Placental location, postpartum hemorrhage and retained placenta in women with a previous cesarean section delivery: a prospective cohort study. Upsala Journal of Medical Sciences, 122(3), 185-189
Open this publication in new window or tab >>Placental location, postpartum hemorrhage and retained placenta in women with a previous cesarean section delivery: a prospective cohort study
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 3, p. 185-189Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women.

MATERIALS AND METHODS: We performed a prospective cohort study on 400 women with cesarean section delivery in a previous pregnancy. Ultrasound examinations were performed at gestational week 28-30, and placental location, myometrial thickness, and three-dimensional vascularization index (VI) were recorded. Data on maternal age, parity, BMI, smoking, gestational week at delivery, induction, delivery mode, oxytocin, preeclampsia, PPH, retained placenta, and birth weight were obtained for all women. Outcome measures were PPH (≥1,000 mL) and retained placenta.

RESULTS: The overall incidence of PPH was 11.0% and of retained placenta 3.5%. Twenty-three women (11.8%) with anterior placenta had PPH compared to 12 (6.9%) with posterior or fundal locations. The odds ratio was 1.94, but it did not reach statistical significance. There was no significant risk increase for retained placenta in women with anterior placentae. Seven of eight women with placenta previa had PPH, and four had retained placenta.

CONCLUSIONS: The overall risk of PPH and retained placenta was high for women with previous cesarean section. Anterior location of the placenta in such women tended to impose an increased risk for PPH but no risk increase of retained placenta. Placenta previa in women with previous cesarean section is associated with a high risk for PPH and retained placenta.

Keywords
Postpartum hemorrhage, previous cesarean section, retained placenta, ultrasound, vascularization index
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-331203 (URN)10.1080/03009734.2017.1356405 (DOI)000414107800005 ()28826360 (PubMedID)
Available from: 2017-10-12 Created: 2017-10-12 Last updated: 2018-02-14Bibliographically approved
Wilbe, M., Ekvall, S., Eurenius, K., Ericson, K., Casar-Borota, O., Klar, J., . . . Bondeson, M.-L. (2015). MuSK: a new target for lethal fetal akinesia deformation sequence (FADS).. Journal of Medical Genetics, 52(3), 195-202
Open this publication in new window or tab >>MuSK: a new target for lethal fetal akinesia deformation sequence (FADS).
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2015 (English)In: Journal of Medical Genetics, ISSN 0022-2593, E-ISSN 1468-6244, Vol. 52, no 3, p. 195-202Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Fetal akinesia deformation sequence syndrome (FADS, OMIM 208150) is characterised by decreased fetal movement (fetal akinesia) as well as intrauterine growth restriction, arthrogryposis, and developmental anomalies (eg, cystic hygroma, pulmonary hypoplasia, cleft palate, and cryptorchidism). Mutations in components of the acetylcholine receptor (AChR) pathway have previously been associated with FADS.

METHODS AND RESULTS: We report on a family with recurrent fetal loss, where the parents had five affected fetuses/children with FADS and one healthy child. The fetuses displayed no fetal movements from the gestational age of 17 weeks, extended knee joints, flexed hips and elbows, and clenched hands. Whole exome sequencing of one affected fetus and the parents was performed. A novel homozygous frameshift mutation was identified in muscle, skeletal receptor tyrosine kinase (MuSK), c.40dupA, which segregated with FADS in the family. Haplotype analysis revealed a conserved haplotype block suggesting a founder mutation. MuSK (muscle-specific tyrosine kinase receptor), a component of the AChR pathway, is a main regulator of neuromuscular junction formation and maintenance. Missense mutations in MuSK have previously been reported to cause congenital myasthenic syndrome (CMS) associated with AChR deficiency.

CONCLUSIONS: To our knowledge, this is the first report showing that a mutation in MuSK is associated with FADS. The results support previous findings that CMS and/or FADS are caused by complete or severe functional disruption of components located in the AChR pathway. We propose that whereas milder mutations of MuSK will cause a CMS phenotype, a complete loss is lethal and will cause FADS.

National Category
Medical Genetics Basic Medicine Clinical Laboratory Medicine
Research subject
Pathology
Identifiers
urn:nbn:se:uu:diva-245479 (URN)10.1136/jmedgenet-2014-102730 (DOI)000349874700007 ()25612909 (PubMedID)
Available from: 2015-02-26 Created: 2015-02-26 Last updated: 2019-01-04
Belachew, J., Axelsson, O., Eurenius, K. & Mulic-Lutvica, A. (2015). Three-dimensional ultrasound does not improve diagnosis of retained placental tissue compared to two-dimensional ultrasound. Acta Obstetricia et Gynecologica Scandinavica, 94(1), 112-116
Open this publication in new window or tab >>Three-dimensional ultrasound does not improve diagnosis of retained placental tissue compared to two-dimensional ultrasound
2015 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 1, p. 112-116Article in journal (Refereed) Published
Abstract [en]

The study objective was to improve ultrasonic diagnosis of retained placental tissue by measuring the volume of the uterine body and cavity using three-dimensional (3D) ultrasound. Twenty-five women who were to undergo surgical curettage due to suspected retained placental tissue were included. The volume of the uterine body and cavity was measured using the VOCAL imaging program. Twenty-one women had retained placental tissue histologically verified. Three of these had uterine volumes exceeding the largest volume observed in the normal puerperium. Seventeen of the 21 women had a uterine cavity volume exceeding the largest volume observed in the normal puerperium. In all 14 cases examined 28 days or more after delivery the cavity volume exceeded the largest volume observed in the normal puerperium. A large cavity volume estimated with 3D ultrasound is indicative of retained placental tissue. However, 3D ultrasound adds little or no diagnostic power compared to 2D ultrasound.

National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-240535 (URN)10.1111/aogs.12502 (DOI)000346704100019 ()25303033 (PubMedID)
Available from: 2015-01-07 Created: 2015-01-07 Last updated: 2017-12-05Bibliographically approved
Belachew, J., Cnattingius, S., Mulic-Lutvica, A., Eurenius, K., Axelsson, O. & Wikström, A.-K. (2014). Risk of retained placenta in women previously delivered by caesarean section: a population-based cohort study.. British Journal of Obstetrics and Gynecology, 121(2), 224-229
Open this publication in new window or tab >>Risk of retained placenta in women previously delivered by caesarean section: a population-based cohort study.
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2014 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 121, no 2, p. 224-229Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To evaluate whether women with a caesarean section at their first delivery have an increased risk of retained placenta at their second delivery.

DESIGN: Population-based cohort study.

SETTING: Sweden.

POPULATION: All women with their first and second singleton deliveries in Sweden during the years 1994-2006 (n = 258 608). Women with caesarean section or placental abruption in their second pregnancy were not included in the study population.

METHODS: The risk of retained placenta at second delivery was estimated for women with a first delivery by caesarean section (n = 19 458), using women with a first vaginal delivery as reference (n = 239 150). Risks were calculated as odds ratios by unconditional logistic regression analysis with 95% confidence intervals (95%) after adjustments for maternal, delivery, and infant characteristics.

MAIN OUTCOME MEASURES: Retained placenta with normal (≤1000 ml) and heavy (>1000 ml) bleeding.

RESULTS: The overall rate of retained placenta was 2.07%. In women with a previous caesarean section and in women with previous vaginal delivery, the corresponding rates were 3.44% and 1.96%, respectively. Compared with women with a previous vaginal delivery, women with a previous caesarean section had an increased risk of retained placenta (adjusted OR 1.45; 95% CI 1.32-1.59), and the association was more pronounced for retained placenta with heavy bleeding (adjusted OR 1.61; 95% CI 1.44-1.79).

CONCLUSIONS: Our report shows an increased risk for retained placenta in women previously delivered by caesarean section, a finding that should be considered in discussions of mode of delivery.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-214810 (URN)10.1111/1471-0528.12444 (DOI)000328863800017 ()24044730 (PubMedID)
Available from: 2014-01-09 Created: 2014-01-09 Last updated: 2017-12-06Bibliographically approved
Lutvica, A., Belachew, J., Axelsson, O. & Eurenius, K. (2012). Longitudinal study of the uterine body and cavity with 3D-ultrasonography in the puerperium. Acta Obstetricia et Gynecologica Scandinavica, 91, 109-109
Open this publication in new window or tab >>Longitudinal study of the uterine body and cavity with 3D-ultrasonography in the puerperium
2012 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 91, p. 109-109Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-177441 (URN)000304987600185 ()
Available from: 2012-12-13 Created: 2012-07-13 Last updated: 2017-12-06Bibliographically approved
Belachew, J., Axelsson, O., Mulic-Lutvica, A. & Eurenius, K. (2012). Longitudinal study of the uterine body and cavity with three-dimensional ultrasonography in the puerperium. Acta Obstetricia et Gynecologica Scandinavica, 91(10), 1184-1190
Open this publication in new window or tab >>Longitudinal study of the uterine body and cavity with three-dimensional ultrasonography in the puerperium
2012 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 91, no 10, p. 1184-1190Article in journal (Refereed) Published
Abstract [en]

Objective.

To describe uterine involution in the puerperium with three-dimensional ultrasound.

Design.

Prospective, longitudinal study.

Setting.

Fetal medicine unit, department of obstetrics and gynecology, university referral hospital, Uppsala, Sweden.

Population.

Fifty women with uncomplicated deliveries and puerperium between February 2009 and February 2010.

Methods.

Three-dimensional ultrasound was used to measure the uterine body and cavity volumes. The volume data set was analysed using virtual organ computer-aided analysis (VOCAL) with a 30 degree rotation step. Measurements were performed transabdominally on days 1, 7 and 14 and transvaginally on days 28 and 56 postpartum. Parity, gestational age, birthweight, smoking, breastfeeding and blood loss were recorded.

Main outcome measures.

Uterine body and cavity volumes. Results. Median uterine body volume was 756 cm3 on day 1, 440 cm3 on day 7, 253 cm3 on day 14, 125 cm3 on day 28 and 68 cm3 on day 56. Median cavity volume was 22 cm3 on day 1, 18 cm3 on day 7, 6 cm3 on day 14, 1 cm3 on day 28 and not measurable on day 56. The interindividual variation of uterine body and cavity volumes was most pronounced on day 1 and decreased throughout the observation period. Intrauterine content was found in 36% of the women on day 1, 95% on day 7, 87% on day 14 and 28% on day 28.

Conclusions.

Three-dimensional ultrasound is a non-invasive tool suitable for measurement of the uterine body and cavity volumes during the puerperium. The volumes decreased in a similar pattern in the study population.

National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-182446 (URN)10.1111/j.1600-0412.2012.01418.x (DOI)000308887300009 ()22497320 (PubMedID)
Available from: 2012-10-10 Created: 2012-10-10 Last updated: 2017-12-07Bibliographically approved
Mulic-Lutvica, A., Eurenius, K. & Axelsson, O. (2007). Longitudinal study of Doppler flow resistance indices of the uterine arteries after normal vaginal delivery. Acta Obstetricia et Gynecologica Scandinavica, 86(10), 1207-1214
Open this publication in new window or tab >>Longitudinal study of Doppler flow resistance indices of the uterine arteries after normal vaginal delivery
2007 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 86, no 10, p. 1207-1214Article in journal (Refereed) Published
Abstract [en]

Objectives. To measure Doppler flow resistance indices in the uterine arteries, and to observe when the early diastolic notches appear during the normal puerperium. Methods. Some 45 women took part in this prospective longitudinal study after normal, vaginal delivery. Ultrasound examinations were scheduled for days 1, 3, 7, 14, 28 and 56 postpartum. A transabdominal probe was used during the first two postpartum weeks, and a transvaginal probe for the later examinations. The pulsatility (PI) and resistance (RI) indices in the uterine arteries were measured, and the presence or absence of early diastolic notches was recorded. Results. Compared to day one, the resistance indices did not change markedly until day 28 postpartum. The mean PI was 1.23 at day 1, 1.22 at day 3, 1.22 at day 7, 1.33 at day 14, 1.81 at day 28, and 2.25 at day 56. The mean RI was 0.65 at day 1, 0.65 at day 3, 0.66 at day 7, 0.65 at day 14, 0.77 at day 28, and 0.84 at day 56. The presence of at least 1 uterine artery notch was found in 13.3% of the women at day 1, and in 90.6% at day 56 postpartum. Bilateral notches were recorded in 6.7% of the women at day 1, and in 84.4% at day 56 postpartum. Conclusion. Reference values of the resistance indices from uncomplicated puerperium are needed when the diagnostic efficacy of Doppler ultrasound for pathological conditions is to be tested. This study confirms that the time needed for the vascular physiology to revert from a pregnant to a non-pregnant state appears to be longer than previously assumed.

Keywords
Doppler, ultrasound, uterine artery, postpartum
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-95794 (URN)10.1080/00016340701621569 (DOI)000250201400009 ()17882552 (PubMedID)
Available from: 2007-04-19 Created: 2007-04-19 Last updated: 2017-12-14Bibliographically approved
Larsson, M., Aneblom, G., Eurenius, K., Westerling, R. & Tydén, T. (2006). Limited impact of an intervention regarding emergency contraceptive pills in Sweden: repeated surveys among abortion applicants. European journal of contraception & reproductive health care, 11(4), 270-276
Open this publication in new window or tab >>Limited impact of an intervention regarding emergency contraceptive pills in Sweden: repeated surveys among abortion applicants
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2006 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 11, no 4, p. 270-276Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To evaluate a community-based intervention consisting of an information campaign and advance provision of emergency contraceptive pills (ECP) to abortion applicants. METHODS: Submission of repeated waiting room questionnaires to abortion applicants in two cities in mid-Sweden; one intervention city (IC) and one comparison city (CC) in 2002 (IC = 92, CC = 95) and 2003 (IC = 244, CC = 204). RESULTS: The overall response rate was 90%. The percentage of women who had undergone an abortion within the previous year had decreased in the intervention group but not in the comparison group. Almost two-thirds (63%) of the targeted women had noticed the information campaign and one out of three (33%) who had visited a family planning clinic recalled being given information about ECP. There was a small decline in the use of combined oral contraceptives and intrauterine devices over time. After the intervention, women in the intervention city had better knowledge of ECP and had used it more than women in the comparison city did. CONCLUSIONS: More than half of the targeted women had noticed the information campaign and it may have had a limited impact. Further investigations are needed to determine whether advance supply of ECP to abortion applicants can reduce repeat abortions.

Keywords
Emergency contraception, Abortion applicants, Intervention, Knowledge, Attitude, Practice
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-24572 (URN)10.1080/13625180600766347 (DOI)000244282400005 ()17484192 (PubMedID)
Available from: 2008-06-27 Created: 2008-06-27 Last updated: 2017-12-07Bibliographically approved
Mulic Lutvica, A., Eurenius, K. & Axelsson, O. (2006). P13.24 Longitudinal study of uterine artery Doppler after normal vaginal delivery. : 16th World Congress on Ultrasound in Obstetrics and Gynecology (Poster Abstracs)
Open this publication in new window or tab >>P13.24 Longitudinal study of uterine artery Doppler after normal vaginal delivery
2006 (English)Other (Other (popular scientific, debate etc.))
Place, publisher, year, pages
16th World Congress on Ultrasound in Obstetrics and Gynecology (Poster Abstracs), 2006. p. 594
Series
Ultrasound Obstet Gynecol
Identifiers
urn:nbn:se:uu:diva-25984 (URN)
Available from: 2007-02-14 Created: 2007-02-14
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