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Hansson, Mats G.
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Publications (10 of 98) Show all publications
Matar, A., Höglund, A. T. & Hansson, M. G. (2018). “A perfect society”— Swedish policymakers’ ethical and social views on preconception expanded carrier screening. Journal of Community Genetics
Open this publication in new window or tab >>“A perfect society”— Swedish policymakers’ ethical and social views on preconception expanded carrier screening
2018 (English)In: Journal of Community Genetics, ISSN 1868-310X, E-ISSN 1868-6001Article in journal (Refereed) Published
Abstract [en]

To improve healthcare policymaking, commentators have recommended the use of evidence, health technology assessment, priority setting, and public engagement in the process of policymaking. Preconception expanded carrier screening, according to the World Health Organization’s definition, is a novel health technology and therefore warrants assessment, part of which involves evaluating ethical and social implications. We examined ten Swedish policymakers’ perspectives on ethical and social aspects of preconception expanded screening through in-depth expert interviewing, using a semi-structured questionnaire. Respondents were affiliated to governmental and non-governmental institutions that directly influence healthcare policymaking in Sweden. The interviews were recorded, transcribed verbatim, and analyzed via inductive thematic analysis method, which generated seven themes and several subthemes. Policymakers harbored concerns regarding the economics, Swedish and international political respects, implementation procedures, and societal effects, which included long-term ones. Moreover, participants detailed the role of public engagement, research, and responsibility in regard to preconception expanded carrier screening implementation. Since this is a qualitative study, with a small non-random sample, the results may not be generalizable to all policymakers in Sweden. However, the results give a profound insight into the process and interpretative knowledge of experts, in the Swedish milieu and the extent of readiness of Sweden to implement a preconception expanded carrier screening program.

Place, publisher, year, edition, pages
Springer, 2018
Keywords
Preconception Expanded carrier screening Genetic Policymakers Reproductive decision-making Ethics Social effects
National Category
Other Medical Biotechnology Other Health Sciences
Identifiers
urn:nbn:se:uu:diva-362390 (URN)10.1007/s12687-018-0389-x (DOI)
Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2019-01-11Bibliographically approved
Renzi, C., Provencal, N., Bassil, K. C., Evers, K., Kihlbom, U., Radford, E. J., . . . Rutten, B. P. (2018). From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health.. Progress in Molecular Biology and Translational Science, 158, 299-323
Open this publication in new window or tab >>From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health.
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2018 (English)In: Progress in Molecular Biology and Translational Science, ISSN 1877-1173, E-ISSN 1878-0814, Vol. 158, p. 299-323Article, review/survey (Refereed) Published
Abstract [en]

The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.

Keywords
Brain development, Environment, Epidemiology, Epigenetics, Genetics, Gene–environment interactions, Mental disorders, Mental health, Neuronal epigenesis
National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-372312 (URN)10.1016/bs.pmbts.2018.04.011 (DOI)000452377300013 ()30072059 (PubMedID)
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-17Bibliographically approved
Hansson, M. G., Bouder, F. & Howard, H. C. (2018). Genetics and risk - an exploration of conceptual approaches to genetic risk. Journal of Risk Research, 21(2), 101-108
Open this publication in new window or tab >>Genetics and risk - an exploration of conceptual approaches to genetic risk
2018 (English)In: Journal of Risk Research, ISSN 1366-9877, E-ISSN 1466-4461, Vol. 21, no 2, p. 101-108Article in journal, Editorial material (Other academic) Published
National Category
Social Sciences Medical Ethics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-347113 (URN)10.1080/13669877.2017.1382562 (DOI)000419609100001 ()
Funder
Riksbankens Jubileumsfond, M13-0260:1
Available from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-03-26Bibliographically approved
Viberg, J., Segerdahl, P., Hösterey Ugander, U., Hansson, M. G. & Langenskiöld, S. (2018). Making sense of genetic risk: A qualitative focus-group study of healthy participants in genomic research. Patient Education and Counseling, 101(3), 422-427
Open this publication in new window or tab >>Making sense of genetic risk: A qualitative focus-group study of healthy participants in genomic research
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2018 (English)In: Patient Education and Counseling, ISSN 0738-3991, E-ISSN 1873-5134, Vol. 101, no 3, p. 422-427Article in journal (Refereed) Published
Abstract [en]

Objective

It is well known that research participants want to receive genetic risk information that is about high risks, serious diseases and potential preventive measures. The aim of this study was to explore, by qualitative means, something less well known: how do healthy research participants themselves make sense of genetic risk information?

Method

A phenomenographic approach was chosen to explore research participants’ understanding and assessment of genetic risk. We conducted four focus-group (N = 16) interviews with participants in a research programme designed to identify biomarkers for cardiopulmonary disease.

Results

Among the research participants, we found four ways of understanding genetic risk: as a binary concept, as an explanation, as revealing who I am (knowledge of oneself) and as affecting life ahead.

Conclusion

Research participants tend to understand genetic risk as a binary concept. This does not necessarily imply a misunderstanding of, or an irrational approach to, genetic risk. Rather, it may have a heuristic function in decision-making.

Practical implications

Risk communication may be enhanced by tailoring the communication to the participants’ own lay conceptions. For example, researchers and counselors should address risk in binary terms, maybe looking out for how individual participants search for threshold figures.

Keywords
Lay understanding; Conception of genetic risk; Making sense of genetic risk in research; Genetic risk communication
National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-330221 (URN)10.1016/j.pec.2017.09.009 (DOI)000427826300007 ()
Available from: 2017-09-27 Created: 2017-09-27 Last updated: 2018-08-01Bibliographically approved
Schölin Bywall, K., Veldwijk, J., Hansson, M. G. & Kihlbom, U. (2018). Patient Perspectives on the Value of Patient Preference Information in Regulatory Decision Making: A Qualitative Study in Swedish Patients with Rheumatoid Arthritis. the patient - patient-centered outcomes research
Open this publication in new window or tab >>Patient Perspectives on the Value of Patient Preference Information in Regulatory Decision Making: A Qualitative Study in Swedish Patients with Rheumatoid Arthritis
2018 (English)In: the patient - patient-centered outcomes research, ISSN 1178-1653Article in journal (Refereed) Published
Abstract [en]

Background

There is increasing interest in involving patient preferences for benefits and risks in regulatory decision making. Therefore, it is essential to identify patient perspectives regarding the value of patient preference information (PPI).

Objectives

The aim of this study was to explore how patients with rheumatoid arthritis (RA) value the use of PPI in regulatory decision making regarding medical products.

Methods

Regulators and patients with RA were interviewed to gather initial insights into opinions on the use of PPI in regulatory decisions regarding medical products. The interviews were used to draft and validate the interview guide for focus groups with patients with RA. Participants were purposively sampled in collaboration with the Swedish Rheumatism Association in Stockholm and Uppsala. Each focus group consisted of three to six patients (18 in total). All interviews were audio-recorded, transcribed verbatim, and analysed using content analysis.

Results

According to the participants, PPI could lead to regulators considering patients’ needs, lifestyles and well-being when making decisions. PPI was important in all stages of the medical product lifecycle. Participants reported that, when participating in a preference study, it is important to be well-informed about the use of the study and the development, components, administration, and risks related to the medical products.

Conclusions

Patients thought PPI could be valuable to consider in regulatory decisions. It is essential for patients to be well-informed when asked for their preferences. Research on information materials to inform patients in preference studies is needed to increase the value of PPI in regulatory decision making.

National Category
Medical Ethics
Identifiers
urn:nbn:se:uu:diva-366354 (URN)10.1007/s40271-018-0344-2 (DOI)
Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2019-02-13Bibliographically approved
Bayliss, K., Raza, K., Simons, G., Falahee, M., Hansson, M. G., Starling, B. & Stack, R. (2018). Perceptions of predictive testing for those at risk of developing a chronic inflammatory disease: a meta-synthesis of qualitative studies. Journal of Risk Research, 21(2), 167-189
Open this publication in new window or tab >>Perceptions of predictive testing for those at risk of developing a chronic inflammatory disease: a meta-synthesis of qualitative studies
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2018 (English)In: Journal of Risk Research, ISSN 1366-9877, E-ISSN 1466-4461, Vol. 21, no 2, p. 167-189Article in journal (Refereed) Published
Abstract [en]

Background: The availability of tests to predict the risk of developing chronic diseases is increasing. The identification of individuals at high risk of disease can trigger early intervention to reduce the risk of disease and its severity. In order for predictive tests to be accepted and used by those at risk, there is a need to understand people's perceptions of predictive testing.

Method: A meta-synthesis of qualitative research that explored patient and public perceptions of predictive testing for chronic inflammatory diseases was conducted. Studies were coded by researchers and patient research partners, and then organised into common themes associated with the acceptability or use of predictive testing.

Results: Perceived barriers to predictive testing were identified, including a concern about a lack of confidentiality around the use of risk information; a lack of motivation for change; poor communication of information; and a possible impact on emotional well-being. In order to reduce these barriers, the literature shows that a patient-centred approach is required at each stage of the testing process. This includes the consideration of individual needs, such as accessibility and building motivation for change; readily available and easy to understand pre and post-test information; support for patients on how to deal with the implications of their results; and the development of condition specific lifestyle intervention programmes to facilitate sustainable lifestyle changes.

Conclusion: Patients and members of the public had some concerns about predictive testing; however, a number of strategies to reduce barriers and increase acceptability are available. Further research is required to inform the development of a resource that supports the individual to make an informed decision about whether to engage in a predictive test, what test results mean, and how to access post-test support.

Place, publisher, year, edition, pages
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2018
Keywords
chronic disease, predictive testing, perceptions, risk, qualitative research, synthesis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-341315 (URN)10.1080/13669877.2015.1119183 (DOI)000419609100005 ()
Funder
EU, FP7, Seventh Framework Programme, FP7-HEALTH-F2-2012-305549Riksbankens Jubileumsfond, M13-0260:1
Available from: 2018-02-09 Created: 2018-02-09 Last updated: 2018-02-09Bibliographically approved
de Bekker-Grob, E., Berlin, C., Levitan, B., Raza, K., Christoforidi, K., Cleemput, I., . . . Hansson, M. G. (2017). Giving Patients’ Preferences a Voice in Medical Treatment Life Cycle: The PREFER Public–Private Project. Patient, 10(3), 263-266
Open this publication in new window or tab >>Giving Patients’ Preferences a Voice in Medical Treatment Life Cycle: The PREFER Public–Private Project
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2017 (English)In: Patient, ISSN 1178-1653, E-ISSN 1178-1661, Vol. 10, no 3, p. 263-266Article in journal, Editorial material (Refereed) Published
Place, publisher, year, edition, pages
Springer, 2017
Keywords
Outcomes research, patients, drug developmetn, life-cycle, preferences
National Category
Social Sciences Interdisciplinary Medical and Health Sciences Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Social Pharmacy
Identifiers
urn:nbn:se:uu:diva-317971 (URN)10.1007/s40271-017-0222-3 (DOI)000401162700001 ()28247251 (PubMedID)
Projects
IMI-PREFER
Funder
EU, Horizon 2020, 115966
Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2018-01-13Bibliographically approved
Falahee, M., Simons, G., Buckley, C. D., Hansson, M. G., Stack, R. J. & Raza, K. (2017). Patients' Perceptions of Their Relatives' Risk of Developing Rheumatoid Arthritis and of the Potential for Risk Communication, Prediction, and Modulation. Arthritis care & research, 69(10), 1558-1565
Open this publication in new window or tab >>Patients' Perceptions of Their Relatives' Risk of Developing Rheumatoid Arthritis and of the Potential for Risk Communication, Prediction, and Modulation
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2017 (English)In: Arthritis care & research, ISSN 2151-464X, E-ISSN 2151-4658, Vol. 69, no 10, p. 1558-1565Article in journal (Refereed) Published
Abstract [en]

Objective: To understand the perspectives of patients with rheumatoid arthritis (RA) about the risk of their relatives developing RA in the future, and about communicating with their relatives concerning risk and its modulation.

Methods: Twenty-one RA patients took part in semistructured interviews.

Results: Participants reported willingness to communicate with relatives about their risk of developing RA, but described choosing which relatives to communicate with, on the basis of the relatives' perceived receptivity to such risk information. Participants described the potential for risk information to cause negative emotions. Some participants did not consider RA to be hereditable, and few reported smoking as a risk factor. Patients described a lack of public awareness about the causes of RA and the negative impact that RA has on the quality of life. Awareness of this negative impact was identified as an important driver for predictive and preventive strategies. Participants held positive perceptions of predictive testing for RA, though the results of predictive tests were conceptualized as having a high degree of accuracy. Negative views of predictive testing were associated with an appreciation of the probabilistic nature of risk information. Participants felt that their relatives would prefer lifestyle modification over medication as a risk reduction strategy.

Conclusion: Information about risk factors for RA, and the potential impact of RA on the quality of life, is needed to support family communication about RA risk. Management of expectations is needed in relation to the probabilistic nature of risk information, and appropriate support should be provided for negative psychological outcomes.

Place, publisher, year, edition, pages
WILEY, 2017
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:uu:diva-336436 (URN)10.1002/acr.23179 (DOI)000411811900013 ()27998043 (PubMedID)
Funder
Riksbankens Jubileumsfond, M13-0260:1EU, FP7, Seventh Framework Programme, FP7-HEALTH-F2-2012-305549
Available from: 2017-12-14 Created: 2017-12-14 Last updated: 2017-12-14Bibliographically approved
Schölin Bywall, K., Veldwijk, J., Hansson, M. G. & Kihlbom, U. (2017). Rheumatoid Arthritis Patients’ Perspectives On The Value Of Patient Preferences In Regulatory Decision-Making During Drug Development: A Qualitative Study. Value in Health, 20(9), A540-A540
Open this publication in new window or tab >>Rheumatoid Arthritis Patients’ Perspectives On The Value Of Patient Preferences In Regulatory Decision-Making During Drug Development: A Qualitative Study
2017 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 20, no 9, p. A540-A540Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-345691 (URN)10.1016/j.jval.2017.08.801 (DOI)000413599901148 ()
Projects
IMI-PREFER
Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-10-04Bibliographically approved
Oliveri, S., Howard, H. C., Renzi, C., Hansson, M. . & Pravettoni, G. (2016). Anxiety delivered direct-to-consumer: are we asking the right questions about the impacts of DTC genetic testing?. Journal of Medical Genetics, 53(12), 798-799
Open this publication in new window or tab >>Anxiety delivered direct-to-consumer: are we asking the right questions about the impacts of DTC genetic testing?
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2016 (English)In: Journal of Medical Genetics, ISSN 0022-2593, E-ISSN 1468-6244, Vol. 53, no 12, p. 798-799Article in journal, Editorial material (Refereed) Published
National Category
Medical Ethics Medical Genetics
Identifiers
urn:nbn:se:uu:diva-316212 (URN)10.1136/jmedgenet-2016-104184 (DOI)000391457200002 ()27647845 (PubMedID)
Available from: 2017-02-27 Created: 2017-02-27 Last updated: 2018-01-13Bibliographically approved
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