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Bingefors, K
Alternative names
Publications (10 of 14) Show all publications
Thunander Sundbom, L., Bingefors, K., Hedborg, K. & Isacson, D. (2017). Are men under-treated and women over-treated with antidepressants?: Findings from a cross-sectional survey in Sweden. BJPsych bulletin, 41(3), 145-150
Open this publication in new window or tab >>Are men under-treated and women over-treated with antidepressants?: Findings from a cross-sectional survey in Sweden
2017 (English)In: BJPsych bulletin, ISSN 2056-4694, E-ISSN 2056-4708, Vol. 41, no 3, p. 145-150Article in journal (Refereed) Published
Abstract [en]

Aims and method: To examine gender differences in self-reported depression and prescribed antidepressants (ADs). The Hospital Anxiety and Depression Scale was used to assess depression, and information on prescribed ADs was obtained from the Swedish Prescribed Drug Register.

Results: Depression was reported by 11.7% of the participants (12.3% men and 11.2% women). ADs were prescribed for 7.6% of the participants (5.3% men, 9.8% women). Among men, 1.8% reported depression and used ADs, 10.5% reported depression but did not use ADs, and 3.6% used ADs but did not report depression. The corresponding figures for women were 2.6%, 8.6% and 7.2%.

Clinical implications: Men report depression to a greater extent than women but are prescribed ADs to a lesser extent, possibly a sign of under-treatment. Women are prescribed ADs without reporting depression more often than men, possibly a sign of over-treatment. Although the causes remain unclear, diagnostic and treatment guidelines should benefit from considering gender differences in these respects.

Keywords
Self-reported depression, Antidepressants, Gender differences, Over-treatment, Under-treatment
National Category
Pharmaceutical Sciences Psychiatry
Research subject
Pharmacoepidemiology
Identifiers
urn:nbn:se:uu:diva-310328 (URN)10.1192/pb.bp.116.054270 (DOI)000407961600004 ()28584650 (PubMedID)
Available from: 2016-12-14 Created: 2016-12-14 Last updated: 2018-05-04Bibliographically approved
Thunander Sundbom, L., Bingefors, K. & Isacson, D. (2015). Self-Reported Depression and Prescription of Antidepressants; does Gender Matter?. Value in Health, 18(3), A116-A116
Open this publication in new window or tab >>Self-Reported Depression and Prescription of Antidepressants; does Gender Matter?
2015 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 18, no 3, p. A116-A116Article in journal, Meeting abstract (Other academic) Published
National Category
Public Health, Global Health, Social Medicine and Epidemiology Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:uu:diva-257478 (URN)10.1016/j.jval.2015.03.684 (DOI)000354498502027 ()
Note

PMH12

Available from: 2015-08-17 Created: 2015-07-02 Last updated: 2017-12-04Bibliographically approved
Lindberg, M., Isacson, D. & Bingefors, K. (2014). Self-reported Skin Diseases, Quality of Life and Medication Use: A Nationwide Pharmaco-epidemiological Survey in Sweden. Acta Dermato-Venereologica, 94(2), 188-191
Open this publication in new window or tab >>Self-reported Skin Diseases, Quality of Life and Medication Use: A Nationwide Pharmaco-epidemiological Survey in Sweden
2014 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 94, no 2, p. 188-191Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to determine self-reported consumption of dermatological pharmaceuticals and quality of life (QoL), measured with Short Form 36, in relation to eczema, acne, psoriasis and other inflammatory skin conditions in the Swedish population. A questionnaire containing questions on the occurrence of skin diseases, health-related QoL and the use of pharmaceuticals was sent to a cross-sectional sample of the Swedish population, age range 18-84 years (n =8,000). The response rate was 61%. The 1-year prevalence of skin diseases was 30-35%, with females reporting a higher prevalence. The prevalence was 11.5% for eczema other than hand eczema, 10.2% for acne, 7.5% for hand eczema, 3.9% for psoriasis and 3.1% for urticaria. QoL was significantly affected and 25% of females and 19% of males had used a dermatological drug. Compared with hand eczema, persons with psoriasis and other eczema reported significantly more use of topical steroids on prescription and more use of dermatological pharmaceuticals in total. Skin conditions are common; they affect QoL and lead to a high consumption of dermatological drugs; which deserves increased awareness in the society.

Keywords
skin diseases, quality of life, pharmacoepidemiology, dermatological agents
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-223580 (URN)10.2340/00015555-1672 (DOI)000332820000012 ()
Available from: 2014-04-24 Created: 2014-04-22 Last updated: 2017-12-05Bibliographically approved
Edvinsson, D., Lindström, E., Bingefors, K., Lewander, T. & Ekselius, L. (2013). Gender differences of axis I and II comorbidity in subjects diagnosed with attention-deficit hyperactivity disorder as adults. Acta Neuropsychiatrica, 25(3), 165-174
Open this publication in new window or tab >>Gender differences of axis I and II comorbidity in subjects diagnosed with attention-deficit hyperactivity disorder as adults
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2013 (English)In: Acta Neuropsychiatrica, ISSN 0924-2708, E-ISSN 1601-5215, Vol. 25, no 3, p. 165-174Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate gender differences in psychiatric comorbidity patients diagnosed with attention-deficit hyperactivity disorder (ADHD) as adults. Methods: Interviews about current ADHD symptoms and psychiatric comorbidity on axis I and II (Structured Clinical Interview for DSM-IV axis I and axis II) were conducted in a clinical cohort of 168 patients (78 women, 90 men). Independent information on childhood and current symptoms was collected from parents, partners and patient files. Results: The lifetime prevalence of psychiatric comorbidity on axis I reached 92%, and current comorbidity, including autism spectrum disorders and Tourette's syndrome, was 47%. Women had a higher lifetime prevalence of mood and eating disorders compared with men, where substance-use disorders were more frequent. Ten per cent of patients fulfilled diagnostic criteria for a personality disorder. When excluding the general diagnostic criteria, 46% of the patients endorsed the specific criteria for at least one personality disorder. Gender differences were identified with predominance of histrionic personality traits in women and conduct disorder in men. Conclusion: Patients diagnosed with ADHD as adults display an extremely high lifetime axis I comorbidity with a gender-specific pattern similar to the general population. No gender differences were identified with regard to personality disorders; however, an increased prevalence of deviant personality traits was confirmed. This study stresses the importance of evaluating comorbidity among patients diagnosed with ADHD as adults to secure optimal treatment.

Keywords
ADHD, adults, comorbidity, gender
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-204118 (URN)10.1111/j.1601-5215.2012.00682.x (DOI)000320550800006 ()
Available from: 2013-07-22 Created: 2013-07-22 Last updated: 2017-12-06Bibliographically approved
Lindberg, M., Bingefors, K., Meding, B. & Berg, M. (2013). Hand eczema and health-related quality of life; a comparison of EQ-5D and the Dermatology Life Quality Index (DLQI) in relation to the hand eczema extent score (HEES). Contact Dermatitis, 69(3), 138-143
Open this publication in new window or tab >>Hand eczema and health-related quality of life; a comparison of EQ-5D and the Dermatology Life Quality Index (DLQI) in relation to the hand eczema extent score (HEES)
2013 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 69, no 3, p. 138-143Article in journal (Refereed) Published
Abstract [en]

Background. Health-related quality of life (HRQoL) is associated with the extent and severity of hand eczema. We still lack a consensus about which HRQoL instrument to use as the standard, and how to measure the extent and severity of hand eczema. Objectives. To compare the Dermatology Life Quality Index (DLQI) with EQ-5D (a standardized instrument for use as a measure of health outcome), and to evaluate how the Hand Eczema Extent Score (HEES) relates to these instruments. Methods. Ninety-three patients (61 females) were included. The HEES was recorded by a dermatologist, and the DLQI and EQ-5D by the patients. The results were analysed with factor analysis and non-parametric statistics. Results. The DLQI and EQ-5D showed decreased HRQoL. Using factor analysis, we could not establish an association between the DLQI and EQ-5D. There were, however, correlations between the DLQI and the HEES (0.31), the EQ(index) and the HEES (-0.32), the DLQI and the EQ(VAS) (-0.62), and the DLQI and the EQ(index) (-0.67) (the EQ(VAS) and the EQ(index) are calculated from EQ-5D). Conclusions. We could not link factors in the DLQI to EQ-5D, which has previously been done for SF-36 (Short Form 36). On the basis of this, we cannot recommend EQ-5D over SF-36 for hand eczema studies. The DLQI correlates with the EQ(VAS) and the EQ(index), and can probably be used as an approximation for EQ-5D. Our findings with the HEES are interesting, as it can be used by patients.

Keywords
DLQI, EQ-5D, hand eczema, HEES, quality of life
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-206956 (URN)10.1111/cod.12067 (DOI)000323154700002 ()
Available from: 2013-09-09 Created: 2013-09-09 Last updated: 2017-12-06Bibliographically approved
Bingefors, K., Svensson, Å., Isacson, D. & Lindberg, M. (2013). Self-reported Lifetime Prevalence of Atopic Dermatitis and Co-morbidity with Asthma and Eczema in Adulthood: A Population-based Cross-sectional Survey. Acta Dermato-Venereologica, 93(4), 438-441
Open this publication in new window or tab >>Self-reported Lifetime Prevalence of Atopic Dermatitis and Co-morbidity with Asthma and Eczema in Adulthood: A Population-based Cross-sectional Survey
2013 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 93, no 4, p. 438-441Article in journal (Refereed) Published
Abstract [en]

Atopic dermatitis and its co-morbidity with asthma and allergy is well described in younger age groups. However, population-based studies on adults with atopic dermatitis in childhood are sparse. The aims of this study were to determine: (i) the prevalence of self-reported childhood atopic dermatitis in the population; and (ii) its association with present self-reported hand eczema, eczema, allergy, urticaria and asthma. A questionnaire was sent to a cross-sectional random sample of the Swedish population (n = 7,985), age range 18-84 years (response rate 61.1%). The questionnaire included the question "Have you had childhood eczema?" and questions on 5 other medical problems (hand eczema, other eczema, asthma, urticaria and allergy). Persons reporting eczema in childhood reported increased odds ratios (OR) for hand eczema (4.01), other eczema (3.88), urticaria (2.50), allergy (2.98), and asthma (2.06) as adults. The combination of eczema, allergy and asthma had an OR of 14.10 (95% confidence interval 8.44-23.54). Adults in the age range 18-84 years reporting childhood atopic dermatitis still have high co-morbidity with eczema, asthma, urticaria and allergy.

Keywords
atopic dermatitis, co-morbidity, asthma, epidemiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-219891 (URN)10.2340/00015555-1522 (DOI)000330421700010 ()
Available from: 2014-03-06 Created: 2014-03-06 Last updated: 2017-12-05Bibliographically approved
Thunander Sundbom, L. & Bingerfors, K. (2013). The influence of symptoms of anxiety and depression on medication nonadherence and its causes: a population based survey of prescription drug users in Sweden. Patient Preference and Adherence, 7, 805-811
Open this publication in new window or tab >>The influence of symptoms of anxiety and depression on medication nonadherence and its causes: a population based survey of prescription drug users in Sweden
2013 (English)In: Patient Preference and Adherence, ISSN 1177-889X, E-ISSN 1177-889X, Vol. 7, p. 805-811Article in journal (Refereed) Published
Abstract [en]

Purpose: The purpose of this study was to evaluate the associations between self-reported symptoms of anxiety and/or depression, nonadherent (NA) behaviors, and reasons for NA to medication regimens.

Methods: A population based cross-sectional study with questionnaire was performed in the general Swedish population. The participants were 2802 prescription drug users aged 18-84 years. The questionnaire covered use of prescription drugs, symptoms of anxiety and/or depression, based on the Hospital Anxiety and Depression Scale (HADS), various NA behavior types, intentional and unintentional, and various reasons for NA.

Results: Symptoms of anxiety and depression, independently and in combination, were associated with unintentional and intentional NA, with a stronger association with intentional NA. Regarding the reasons given for NA, for example anxiety, independently or in combination with depression, was associated with a fear of developing adverse drug reactions (ADRs). Depression, independently or in combination with anxiety, on the other hand, was associated with the actual development of ADRs.

Conclusion: A cross-sectional design such as this does not allow assessment of causality derived from the results. However, the results indicate that patients experiencing symptoms of psychological distress are at increased risk of NA, especially intentional NA, and could therefore benefit from extra attention from the health care professional. Patients with symptoms of anxiety and/or depression should be identified and monitored for the development and/or fear of ADRs, in order to improve adherence to medication regimens.

Keywords
Medication Adherence, Anxiety symptoms, Depression symptoms, Reasons
National Category
Medical and Health Sciences
Research subject
Pharmacoepidemiology
Identifiers
urn:nbn:se:uu:diva-205574 (URN)10.2147/PPA.S50055 (DOI)000323147600001 ()
Available from: 2013-08-20 Created: 2013-08-20 Last updated: 2017-12-06Bibliographically approved
Thunander Sundbom, L. & Bingefors, K. (2012). Women and men report different behaviours in, and reasons for medication non-adherence: a nationwide Swedish survey. Pharmacy Practice, 10(4), 207-221
Open this publication in new window or tab >>Women and men report different behaviours in, and reasons for medication non-adherence: a nationwide Swedish survey
2012 (English)In: Pharmacy Practice, ISSN 1885-642X, E-ISSN 1886-3655, Vol. 10, no 4, p. 207-221Article in journal (Refereed) Published
Abstract [en]

Objectives

The aim of the present study was to analyse gender differences in self-reported non-adherence (NA) to prescribed medication in the Swedish general population. We aimed to study unintentional and intentional NA as well as the reasons given for NA.

Methods

A questionnaire was mailed to a cross-sectional, random, national sample of people aged 18-84 years in Sweden (n=7985). The response rate was 61.1% (n=4875). The questionnaire covered use of prescription drugs, NA behaviourand reasons for NA.

Results

Use of prescription drugs was reported by 59.5% (n=2802) of the participants, and 66.4% (n=1860) of these participants did not adhere to the prescribed regimen. No overall gender differences in reporting NA were found. However, when analysing the various types of NA behaviour and the reasons for NA, different gender patterns emerged. Men were more likely to report forgetting [OR 0.77 (95% CI 0.65:0.92)], changing the dosage [OR 0.64 (95% CI 0.52:0.79)] and that they had recovered [14.3%, (OR 0.71 (95% CI 0.56:0.90)] as a reason. In contrast, more women than men reported filling the prescription but not taking the drug [OR 1.25 (95% CI 1.02:1.54)] and reported the development of adverse drug reactions (ADRs) [OR 1.89 (95% CI 1.37:2.59)] as a reason more commonly. The gender differences remained, in most cases, after controlling for confounders such as age, socioeconomic factors, medical problems and attitudes toward drugs.

Conclusions

Women and men have different patterns of NA behaviour and different reasons for NA. Therefore, if adherence is to be improved, a wide knowledge of all the reasons for NA is required, along with an understanding of the impact of gender on the outcomes.

 

Keywords
Medication Adherence, Health knowledge, Attitudes, Practice, Health care surveys, Sweden
National Category
Pharmaceutical Sciences
Research subject
Pharmacoepidemiology
Identifiers
urn:nbn:se:uu:diva-193611 (URN)
Available from: 2013-02-05 Created: 2013-02-05 Last updated: 2018-01-11Bibliographically approved
Bingefors, K. (2008). Comparing countries in population studies - is it possible? (1ed.). In: Felicity Smith, Sally-Anne Francis and Ellen Schafheutle (Ed.), International research in healthcare. London: Pharmaceutical Press
Open this publication in new window or tab >>Comparing countries in population studies - is it possible?
2008 (English)In: International research in healthcare / [ed] Felicity Smith, Sally-Anne Francis and Ellen Schafheutle, London: Pharmaceutical Press , 2008, 1Chapter in book (Other academic)
Place, publisher, year, edition, pages
London: Pharmaceutical Press, 2008 Edition: 1
Series
ULLA Pharmacy Series
National Category
Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-102375 (URN)978-0-85369-750-3 (ISBN)
Available from: 2009-05-06 Created: 2009-05-06 Last updated: 2018-01-13Bibliographically approved
Fors, B. M., Isacson, D., Bingefors, K. & Widerlöv, B. (2007). Mortality among persons with schizophrenia in Sweden: An epidemiological study. Nordic Journal of Psychiatry, 61(4), 252-259
Open this publication in new window or tab >>Mortality among persons with schizophrenia in Sweden: An epidemiological study
2007 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 61, no 4, p. 252-259Article in journal (Refereed) Published
Abstract [en]

The objective of the study was to analyse 10-year mortality among persons with schizophrenia from an epidemiological perspective. This cohort study included all persons with schizophrenia (n=255) living in the northern catchment area in Uppsala in 1991, and 1275 subjects from the national population register matched for sex, age and living area. The prevalence of schizophrenia was 0.37% and the mortality rate for individuals with schizophrenia was higher than for referents: 23.0% vs. 11.2%. The higher mortality among those with schizophrenia was mainly the result of unnatural causes and cardiovascular disease, especially in men. Excess mortality from cardiovascular disease was more pronounced in middle age, irrespective of gender. Multivariate analysis revealed higher mortality among individuals with schizophrenia living in the city than among those living in less urbanized areas. People with schizophrenia die more often than those without schizophrenia from unnatural causes or circulatory diseases. Individuals with schizophrenia die sooner from circulatory diseases than those without schizophrenia. Having schizophrenia and living in the city also results in higher mortality than having schizophrenia and living in other areas. The risk of early death from circulatory disease needs to be studied in more detail to reveal the potential respective contributions of intrinsic patient vulnerability, lifestyle factors and side-effects from psychotropic drugs.

Keywords
Cardiovascular, Causes of death, Death rate, Mortality, Schizophrenia, Suicide, Urban
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-95440 (URN)10.1080/08039480701414932 (DOI)000249182000003 ()17763118 (PubMedID)
Available from: 2007-01-30 Created: 2007-01-30 Last updated: 2017-12-14Bibliographically approved
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