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Björkegren, K
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Publications (10 of 30) Show all publications
Karlsson, B., Burell, G., Kristiansson, P., Björkegren, K., Nyberg, F. & Svärdsudd, K. (2019). Decline of substance P levels after stress management with cognitive behaviour therapy in women with the fibromyalgia syndrome. Scandinavian Journal of Pain, 19(3), 473-482
Open this publication in new window or tab >>Decline of substance P levels after stress management with cognitive behaviour therapy in women with the fibromyalgia syndrome
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2019 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 19, no 3, p. 473-482Article in journal (Refereed) Published
Abstract [en]

Background and aims: Substance P (CSF-SP) is known to be elevated in females with fibromyalgia syndrome (FMS). The aims of this study were to evaluate the effect of cognitive behaviour therapy (CBT) on plasma SP levels in women with FMS and to find possible clinical behavioural correlates to plasma SP level changes. Methods: Forty-eight women with FMS were randomly allocated into two groups. Group 1 received the CBT treatment intervention over the course of 6 months while group 2 was waitlisted. CBT was given with a protocol developed to diminish stress and pain. After 6 months, group 2 was given the same CBT treatment as well. All were followed up 1 year after the start of CBT treatment. This approach allowed for two analytical designs a randomised controlled trial (RCT) (n=24 vs. n=24) and a before-and-after treatment design (n=48). All women were repeatedly evaluated by the West Haven-Yale Multidimensional Pain Inventory (MPI) and three other psychometric questionnaires and plasma SP was analysed. Results: In the RCT design, the plasma SP level was 8.79 fmol/mL in both groups at the start of the trial, after adjustment for initial differences. At the end of the RCT, the plasma SP level was 5.25 fmol/mL in the CBT intervention group compared to 8.39 fmol/mL in the control group (p=0.02). In the before-and-after design, the plasma SP was reduced by 33% (p <0.01) after CBT, but returned to the pre-treatment level at follow-up 1 year after the start of CBT treatment. Plasma SP was associated with the MPI dimensions experienced "support from spouses or significant others" and "life control". Conclusions: Plasma SP might be a marker of the effect of CBT in FMS associated with better coping strategies and reduced stress rather than a biochemical marker of pain.

Place, publisher, year, edition, pages
Walter de Gruyter, 2019
Keywords
fibromyalgia, substance P, cognitive behaviour therapy, stress, Westhaven-Yale Multidimensional Pain Inventory, Montgomery-Asberg Depression Rating Scale
National Category
Applied Psychology
Identifiers
urn:nbn:se:uu:diva-390922 (URN)10.1515/sjpain-2018-0324 (DOI)000473300500007 ()30796851 (PubMedID)
Funder
Swedish Research Council, 9459Swedish Rheumatism Association, 51/04Swedish Social Insurance Agency, 11124
Available from: 2019-08-15 Created: 2019-08-15 Last updated: 2019-08-15Bibliographically approved
Karlsson, B., Burell, G., Kristiansson, P., Björkegren, K., Nyberg, F. & Svärdsudd, K. (2014). Neuropeptide Y levels are reduced after cognitive behavioural therapy (CBT) in women with fibromyalgia (FMS). In: : . Paper presented at International Congress of Behavioral Medicine (pp. P569-P569).
Open this publication in new window or tab >>Neuropeptide Y levels are reduced after cognitive behavioural therapy (CBT) in women with fibromyalgia (FMS)
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2014 (English)Conference paper, Published paper (Other academic)
Series
International Journal of Behavioral Medicine, ISSN 1070-5503.12529 21(S1) S1-S216 (2014)
National Category
General Practice
Identifiers
urn:nbn:se:uu:diva-237138 (URN)
Conference
International Congress of Behavioral Medicine
Available from: 2014-11-27 Created: 2014-11-27 Last updated: 2018-01-19
Björk, A., Andersson, Å., Johansson, G., Björkegren, K., Bardel, A. & Kristiansson, P. (2013). Evaluation of sun holiday, diet habits, origin and other factors as determinants of vitamin D status in Swedish primary health care patients: a cross-sectional study with regression analysis of ethnic Swedish and immigrant women. BMC Family Practice, 14, 129
Open this publication in new window or tab >>Evaluation of sun holiday, diet habits, origin and other factors as determinants of vitamin D status in Swedish primary health care patients: a cross-sectional study with regression analysis of ethnic Swedish and immigrant women
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2013 (English)In: BMC Family Practice, ISSN 1471-2296, E-ISSN 1471-2296, Vol. 14, p. 129-Article in journal (Refereed) Published
Abstract [en]

Background

Determinants of vitamin D status measured as 25-OH-vitamin D in blood are exposure to sunlight and intake of vitamin D through food and supplements. It is unclear how large the contributions are from these determinants in Swedish primary care patients, considering the low radiation of UVB in Sweden and the fortification of some foods. Asian and African immigrants in Norway and Denmark have been found to have very low levels, but it is not clear whether the same applies to Swedish patients. The purpose of our study was to identify contributors to vitamin D status in Swedish women attending a primary health care centre at latitude 60°N in Sweden.

Methods

In this cross-sectional, observational study, 61 female patients were consecutively recruited between January and March 2009, irrespective of reason for attending the clinic. The women were interviewed about their sun habits, smoking, education and food intake at a personal appointment and blood samples were drawn for measurements of vitamin D and calcium concentrations.

Results

Plasma concentration of 25-OH-vitamin D below 25 nmol/L was found in 61% (19/31) of immigrant and 7% (2/30) of native women. Multivariate analysis showed that reported sun holiday of one week during the last year at latitude below 40°N with the purpose of sun-bathing and native origin, were significantly, independently and positively associated with 25-OH-vitamin D concentrations in plasma with the strongest association for sun holiday during the past year.

Conclusions

Vitamin D deficiency was common among the women in the present study, with sun holiday and origin as main determinants of 25-OH-vitamin D concentrations in plasma. Given a negative effect on health this would imply needs for vitamin D treatment particularly in women with immigrant background who have moved from lower to higher latitudes.

Keywords: Vitamin D; Sun habits; Immigrant; Women; Primary health care

National Category
General Practice
Identifiers
urn:nbn:se:uu:diva-208596 (URN)10.1186/1471-2296-14-129 (DOI)000324297400001 ()
Available from: 2013-10-04 Created: 2013-10-04 Last updated: 2018-01-19Bibliographically approved
von Celsing, A.-S., Svärdsudd, K., Eriksson, H.-G., Björkegren, K., Eriksson, M. & Wallman, T. (2012). Determinants for return to work among sickness certified patients in general practice. BMC Public Health, 12(1), 1077
Open this publication in new window or tab >>Determinants for return to work among sickness certified patients in general practice
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2012 (English)In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 12, no 1, p. 1077-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Long-term sickness absence is one of the main risk factors for permanent exit out of the labour market. Early identification of the condition is essential to facilitate return to work. The aim of this study was to analyse possible determinants of return to work and their relative impact.

METHODS:

All 943 subjects aged 18 to 63 years, sickness certified at a Primary Health Care Centre in Sweden from 1 January until 31 August 2004, were followed up for three years. Baseline information on sex, age, sick leave diagnosis, employment status, extent of sick leave, and sickness absence during the year before baseline was obtained, as was information on all compensated days of sick leave, disability pension and death during follow-up.

RESULTS:

Slightly more than half the subjects were women, mean age was 39 years. Half of the study population returned to work within 14 days after baseline, and after three years only 15 subjects were still on sick leave. In multivariate proportional hazards regression analysis the extent of previous sick leave, age, being on part-time sick leave, and having a psychiatric, musculoskeletal, cardiovascular, nervous disease, digestive system, or injury or poisoning diagnosis decreased the return to work rate, while being employed increased it. Marital status, sex, being born in Sweden, citizenship, and annual salary had no influence. In logistic regression analyses across follow-up time these variables altogether explained 88-90% of return to work variation.

CONCLUSIONS:

Return to work was positively or negatively associated by a number of variables easily accessible in the GP's office. Track record data in the form of previous sick leave was the most influential variable.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-189477 (URN)10.1186/1471-2458-12-1077 (DOI)000313444400002 ()23241229 (PubMedID)
Available from: 2013-01-02 Created: 2013-01-02 Last updated: 2017-12-06Bibliographically approved
Andersson, S.-O., Björkegren, K., Foldevi, M., Lindgren, S., Rödjer, S., Troein Töllborn, M., . . . Seeberger, A. (Eds.). (2012). Professionell utveckling inom läkaryrket (1ed.). Stockholm: Liber
Open this publication in new window or tab >>Professionell utveckling inom läkaryrket
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2012 (Swedish)Collection (editor) (Other academic)
Place, publisher, year, edition, pages
Stockholm: Liber, 2012. p. 306 Edition: 1
National Category
General Practice
Identifiers
urn:nbn:se:uu:diva-191348 (URN)978-91-47-09967-2 (ISBN)
Available from: 2013-01-10 Created: 2013-01-10 Last updated: 2018-01-11Bibliographically approved
Björk, A., Andersson, K., Kristiansson, P., Björkegren, K., Johansson, G. & Löfvander, M. (2012). Treatment of vitamin D insufficiency in female primary health care patients in Sweden: results from a study at 60N. In: : . Paper presented at Houston Texas 15th Workshop on vitamin D.
Open this publication in new window or tab >>Treatment of vitamin D insufficiency in female primary health care patients in Sweden: results from a study at 60N
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2012 (English)Conference paper, Oral presentation only (Other academic)
National Category
General Practice
Identifiers
urn:nbn:se:uu:diva-245015 (URN)
Conference
Houston Texas 15th Workshop on vitamin D
Available from: 2015-02-24 Created: 2015-02-24 Last updated: 2018-01-19
Björkegren, K., Andersson, A., Ahlqvist, K., Holm, M. & Wohlin, M. (2011). A student run open health clinic. In: AMEE 2011. Paper presented at The International Association for Medical Education, Vienna Austria, 27-31 August 2011 (pp. 72-72).
Open this publication in new window or tab >>A student run open health clinic
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2011 (English)In: AMEE 2011, 2011, p. 72-72Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-156894 (URN)
Conference
The International Association for Medical Education, Vienna Austria, 27-31 August 2011
Note
Meeting AbstractAvailable from: 2011-08-11 Created: 2011-08-11 Last updated: 2012-03-30Bibliographically approved
Billström, R. & Björkegren, K. (2010). Anemier. In: Läkemedelsboken 2009-2010. (pp. 205-213). Sundbyberg: AlfaPrint
Open this publication in new window or tab >>Anemier
2010 (Swedish)In: Läkemedelsboken 2009-2010., Sundbyberg: AlfaPrint , 2010, , p. 1236p. 205-213Chapter in book (Other academic)
Place, publisher, year, edition, pages
Sundbyberg: AlfaPrint, 2010. p. 1236
Series
Läkemedelsboken
Identifiers
urn:nbn:se:uu:diva-156698 (URN)91-85574-59-7 (ISBN)
Available from: 2011-08-08 Created: 2011-08-08 Last updated: 2011-08-22Bibliographically approved
Björkegren, K., Wallander, M.-A., Johansson, S. & Svärdsudd, K. (2009). General symptom reporting in female fibromyalgia patients and referents: a population-based case-referent study. BMC Public Health, 9, 402
Open this publication in new window or tab >>General symptom reporting in female fibromyalgia patients and referents: a population-based case-referent study
2009 (English)In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 9, p. 402-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Fibromyalgia is characterized by widespread musculoskeletal pain and palpation tenderness. In addition to these classic symptoms, fibromyalgia patients tend to report a number of other complaints. What these other complaints are and how often they are reported as compared with related referents from the general population is not very well known. We therefore hypothesized that subjects with fibromyalgia report more of a wide range of symptoms as compared with referents of the same sex and age from the general population. METHODS: 138 women with diagnosed fibromyalgia in primary health care and 401 referents from the general population matched to the cases by sex, age and residential area responded to a postal questionnaire where information on marital status, education, occupational status, income level, immigrant status, smoking habits physical activity, height and weight history and the prevalence of 42 defined symptoms was sought. RESULTS: The cases had lower educational and income levels, were more often unemployed, on sick leave or on disability pension and were more often first generation immigrants than the referents. They were also heavier, shorter and more often had a history of excessive food intake and excessive weight loss. When these differences were taken into account, cases reported not only significantly more presumed fibromyalgia symptoms but also significantly more of general symptoms than the referents. The distribution of symptoms was similar in subjects with fibromyalgia and referents, indicating a generally higher symptom reporting level among the former. CONCLUSION: Subjects with fibromyalgia had a high prevalence of reported general symptoms than referents. Some of these differences may be a consequence of the disorder while others may reflect etiological processes.

Place, publisher, year, edition, pages
BioMed Central, 2009
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-123619 (URN)10.1186/1471-2458-9-402 (DOI)000272235400001 ()19878599 (PubMedID)
Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2017-12-12Bibliographically approved
Björkegren, K. (2007). Atrofisk gastrit, malabsorption och B12-brist. Rondellen, 27
Open this publication in new window or tab >>Atrofisk gastrit, malabsorption och B12-brist
2007 (Swedish)In: Rondellen, ISSN 1654-5974, Vol. 27Article in journal (Other academic) Published
Place, publisher, year, edition, pages
Pedagogförlaget, 2007
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-123707 (URN)
Available from: 2010-04-29 Created: 2010-04-29 Last updated: 2010-07-20Bibliographically approved
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