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Kollberg, Hans
Alternative names
Publications (8 of 8) Show all publications
Kollberg, H. (2015). Avian Antibodies (IgY) to Fight Antibiotic Resistance. Clinical Microbiology: Open Access, 4(2)
Open this publication in new window or tab >>Avian Antibodies (IgY) to Fight Antibiotic Resistance
2015 (English)In: Clinical Microbiology: Open Access, E-ISSN 2327-5073, Vol. 4, no 2Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-268583 (URN)10.4172/2327-5073.1000194 (DOI)
Available from: 2015-12-08 Created: 2015-12-08 Last updated: 2018-03-07Bibliographically approved
Nilsson, E., Kollberg, H., Johannesson, M., Wejåker, P.-E., Carlander, D. & Larsson, A. (2007). More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report. Journal of Medicinal Food, 10(2), 375-378
Open this publication in new window or tab >>More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report
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2007 (English)In: Journal of Medicinal Food, ISSN 1096-620X, E-ISSN 1557-7600, Vol. 10, no 2, p. 375-378Article in journal (Refereed) Published
Abstract [en]

Immunotherapy with specific antibodies is an alternative to antibiotics for the prevention of infections in humans and animals. We have used orally administered immunoglobulin Y (IgY) preparations, purified from eggs of hens immunized with Pseudomonas aeruginosa bacteria, to prevent pulmonary P. aeruginosa infections in a group of patients with cystic fibrosis (CF). Respiratory infections are major problems for CF patients because of the thick mucus in the airways, and chronic P. aeruginosa lung infections occur in virtually all CF patients and cause morbidity and mortality. The IgY-treated group had only 2.5 P. aeruginosa-positive sputum cultures per 100 months, and none of the IgY-treated patients became chronically colonized with P. aeruginosa. In the control group, 13.7 of the cultures per 100 months were positive for P. aeruginosa, and 24% of patients became chronically colonized with P. aeruginosa. The first enrolled patient in this study has now been treated continuously for more than 10 years. During the first 8 years she only had four P. aeruginosa-positive cultures. After 8 years she became chronically infected, but still after 10 years the bacteria have not turned mucoid. No negative side effects of IgY treatment have been noted during these 10 years. To our knowledge this is the longest treatment with specific yolk antibodies for therapeutic purposes.

Keywords
Antibody, Chicken, Cystic fibrosis, Egg, Immunoglobulin, Immunoglobulin Y, Immunotherapy, Pseudomonas aeruginosa, Yolk
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-13549 (URN)10.1089/jmf.2006.214 (DOI)000248224400025 ()17651078 (PubMedID)
Available from: 2008-06-02 Created: 2008-06-02 Last updated: 2017-12-11Bibliographically approved
Wilhelmson, M., Carlander, D., Kreuger, A., Kollberg, H. & Larsson, A. (2005). Oral treatment with yolk antibodies for the prevention of C. albicans in chemotherapy treated children. A feasibility study. Food and Agricultural Immunology, 16(1), 41-45
Open this publication in new window or tab >>Oral treatment with yolk antibodies for the prevention of C. albicans in chemotherapy treated children. A feasibility study
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2005 (English)In: Food and Agricultural Immunology, Vol. 16, no 1, p. 41-45Article in journal (Refereed) Published
Keywords
Oral immunotherapy, Yolk antibodies, C. albicans, children, acute lymphatic leukemia
Identifiers
urn:nbn:se:uu:diva-74508 (URN)
Available from: 2005-10-06 Created: 2005-10-06 Last updated: 2011-01-11
Karlsson, M., Kollberg, H. & Larsson, A. (2004). Chicken IgY. Utilizing the evolutionary advantage.. World Poultry Science, 50(3), 341-348
Open this publication in new window or tab >>Chicken IgY. Utilizing the evolutionary advantage.
2004 (English)In: World Poultry Science, Vol. 50, no 3, p. 341-348Article in journal (Refereed) Published
Keywords
Adult, Aged, Aged; 80 and over, Case-Control Studies, Colitis; Ulcerative/blood/*metabolism/pathology, Colon/metabolism, Colonoscopy, Female, Human, Immunohistochemistry, Male, Middle Aged, Rectum/metabolism, Support; Non-U.S. Gov't, Vascular Endothelial Growth Factor A/blood/*metabolism
Identifiers
urn:nbn:se:uu:diva-72712 (URN)
Available from: 2005-06-03 Created: 2005-06-03 Last updated: 2011-01-12
Kollberg, H., Carlander, D., Olesen, H., Wejåker, P.-E., Johannesson, M. & Larsson, A. (2003). Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study. Pediatric Pulmonology, 35(6), 433-40
Open this publication in new window or tab >>Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study
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2003 (English)In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 35, no 6, p. 433-40Article in journal (Refereed) Published
Abstract [en]

Respiratory infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. Chronic Pseudomonas aeruginosa (PA) infections ultimately occur in virtually all patients. It is impossible to eradicate PA when a patient has been chronically colonized. Immunotherapy with specific egg-yolk antibodies (IgY) may be an alternative to antibiotics for the prevention of PA infections. We wanted to determine if treatment with specific IgY can prolong the period between the first and the second PA colonization? And long-term, can the treatment diminish the number of positive PA cultures and postpone the onset of chronic colonization? CF patients gargled daily with an IgY-antibody preparation, purified from eggs of hens immunized with PA bacteria. They were compared to a group of patients who did not gargle with the preparation. Both groups had their first colonization with PA eradicated by antibiotics. The basic treatment was essentially the same in both groups. In the initial study, the period between the first and second colonization with PA was significantly prolonged for the treated vs. the control group (Kaplan-Meier P = 0.015, Breslow test). In the prolonged study, the treated group had only 2.5 sputum cultures positive for PA per 100 months of observation, and none of these patients became chronically colonized with PA. No adverse events were reported. In the control group, 13.7 cultures per 100 months of observation were positive for PA, and 5 (24%) patients became chronically colonized with PA. This feasibility study shows that antipseudomonal IgY has the potential to effectively prevent PA colonization without any severe adverse effects. A phase III study should be initiated.

Keywords
Adolescent, Adult, Child, Child; Preschool, Cystic Fibrosis/*complications/*microbiology, Feasibility Studies, Humans, Immunoglobulins/*therapeutic use, Pseudomonas Infections/*complications/*prevention & control, Research Support; Non-U.S. Gov't, Sputum/microbiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-74507 (URN)10.1002/ppul.10290 (DOI)12746939 (PubMedID)
Available from: 2005-10-04 Created: 2005-10-04 Last updated: 2017-12-14Bibliographically approved
Carlander, D., Kollberg, H. & Larsson, A. (2002). Duration of specific yolk IgY in the homan oral cavity. Biodrugs, 6, 433
Open this publication in new window or tab >>Duration of specific yolk IgY in the homan oral cavity
2002 (English)In: Biodrugs, Vol. 6, p. 433-Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-64523 (URN)
Available from: 2005-04-19 Created: 2005-04-19 Last updated: 2011-01-13
Carlander, D., Kollberg, H. & Larsson, A. (2002). Retention of Specific Yolk IgY in the Human Oral Cavity.. BioDrugs, 16, 433
Open this publication in new window or tab >>Retention of Specific Yolk IgY in the Human Oral Cavity.
2002 (English)In: BioDrugs, Vol. 16, p. 433-Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-64132 (URN)
Available from: 2005-04-19 Created: 2005-04-19 Last updated: 2011-01-13
Kollberg, H. & Lidman, R. (2001). [Centralization or more money to health care services? A third way--usethe technology!]. Läkartidningen, 98, 855
Open this publication in new window or tab >>[Centralization or more money to health care services? A third way--usethe technology!]
2001 (Swedish)In: Läkartidningen, Vol. 98, p. 855-Article in journal (Other scientific) Published
Identifiers
urn:nbn:se:uu:diva-63081 (URN)
Available from: 2005-04-18 Created: 2005-04-18 Last updated: 2011-01-14
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