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Zheng, R. & Lind, L. (2024). A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases. Scientific Reports, 14(1), Article ID 10645.
Open this publication in new window or tab >>A combined observational and Mendelian randomization investigation reveals NMR-measured analytes to be risk factors of major cardiovascular diseases
2024 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, no 1, article id 10645Article in journal (Refereed) Published
Abstract [en]

Dyslipidaemias is the leading risk factor of several major cardiovascular diseases (CVDs), but there is still a lack of sufficient evidence supporting a causal role of lipoprotein subspecies in CVDs. In this study, we comprehensively investigated several lipoproteins and their subspecies, as well as other metabolites, in relation to coronary heart disease (CHD), heart failure (HF) and ischemic stroke (IS) longitudinally and by Mendelian randomization (MR) leveraging NMR-measured metabolomic data from 118,012 UK Biobank participants. We found that 123, 110 and 36 analytes were longitudinally associated with myocardial infarction, HF and IS (FDR < 0.05), respectively, and 25 of those were associated with all three outcomes. MR analysis suggested that genetically predicted levels of 70, 58 and 7 analytes were associated with CHD, HF and IS (FDR < 0.05), respectively. Two analytes, ApoB/ApoA1 and M-HDL-C were associated with all three CVD outcomes in the MR analyses, and the results for M-HDL-C were concordant in both observational and MR analyses. Our results implied that the apoB/apoA1 ratio and cholesterol in medium size HDL were particularly of importance to understand the shared pathophysiology of CHD, HF and IS and thus should be further investigated for the prevention of all three CVDs.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
NMR, Lipoproteins, Cardiovascular diseases, UK Biobank, Mendelian randomization
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-528687 (URN)10.1038/s41598-024-61440-5 (DOI)001217905100068 ()38724583 (PubMedID)
Funder
Uppsala University
Available from: 2024-05-31 Created: 2024-05-31 Last updated: 2024-05-31Bibliographically approved
Baldanzi, G., Sayols-Baixeras, S., Ekblom-Bak, E., Ekblom, Ö., Dekkers, K. F., Hammar, U., . . . Fall, T. (2024). Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS. EBioMedicine, 100, Article ID 104989.
Open this publication in new window or tab >>Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
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2024 (English)In: EBioMedicine, E-ISSN 2352-3964, Vol. 100, article id 104989Article in journal (Refereed) Published
Abstract [en]

Background

Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from the Swedish CArdioPulmonary bioImage Study.

Methods

In 8416 participants aged 50–65, time in SED, MPA, and VPA were estimated with hip-worn accelerometer. Gut microbiota was profiled using shotgun metagenomics of faecal samples. We applied multivariable regression models, adjusting for sociodemographic, lifestyle, and technical covariates, and accounted for multiple testing.

Findings

Overall, associations between time in SED and microbiota species abundance were in opposite direction to those for MPA or VPA. For example, MPA was associated with lower, while SED with higher abundance of Escherichia coli. MPA and VPA were associated with higher abundance of the butyrate-producers Faecalibacterium prausnitzii and Roseburia spp. We observed discrepancies between specific VPA and MPA associations, such as a positive association between MPA and Prevotella copri, while no association was detected for VPA. Additionally, SED, MPA and VPA were associated with the functional potential of the microbiome. For instance, MPA was associated with higher capacity for acetate synthesis and SED with lower carbohydrate degradation capacity.

Interpretation

Our findings suggest that sedentary and physical activity are associated with a similar set of gut microbiota species but in opposite directions. Furthermore, the intensity of physical activity may have specific effects on certain gut microbiota species.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Accelerometery, Gastrointestinal microbiome, Exercise, Sedentary behaviour, Epidemiology
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-522177 (URN)10.1016/j.ebiom.2024.104989 (DOI)001180180700001 ()38301483 (PubMedID)
Available from: 2024-02-01 Created: 2024-02-01 Last updated: 2024-04-09Bibliographically approved
Ostrowska, B., Lind, L. & Blomström-Lundqvist, C. (2024). An association between heart rate variability and incident heart failure in an elderly cohort. Clinical Cardiology, 47(2)
Open this publication in new window or tab >>An association between heart rate variability and incident heart failure in an elderly cohort
2024 (English)In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 47, no 2Article in journal (Refereed) Published
Abstract [en]

  Background

Early identification of individuals at risk of developing heart failure (HF) may improve poor prognosis. A dominant sympathetic activity is common in HF and associated with worse outcomes; however, less is known about the autonomic balance before HF.

Hypothesis

A low frequency/high frequency (L-F/H-F) ratio, index of heart rate variability, and marker of the autonomic balance predict the development of HF and may improve the performance of the HF prediction model when added to traditional cardiovascular (CV) risk factors.

Methods

Individuals in the PIVUS (Prospective Investigation of the Vasculature in Uppsala Seniors) study (n = 1016, all aged 70 years) were included. Exclusion criteria were prevalent HF, electrocardiographic QRS duration ≥130 millisecond, major arrhythmias, or conduction blocks at baseline. The association between the L-F/H-F ratio and incident HF was assessed using Cox proportional hazard analysis. The C-statistic evaluated whether adding the L-F/H-F-ratio to traditional CV risk factors improved the discrimination of incident HF.

Results

HF developed in 107/836 study participants during 15 years of follow-up. A nonlinear, inverse association between the L-F/H-F ratio and incident HF was mainly driven by an L-F/H-F ratio of <30. The association curve was flat for higher values (hazard ratio, HR for the total curve = 0.78 [95% confidence interval, CI: 0.69−0.88, p < .001]; HR = 2 for L-F/H-F ratio = 10). The traditional prediction model improved by 3.3% (p < .03) when the L-F/H-F ratio was added.

Conclusions

An L-F/H-F ratio of <30 was related to incident HF and improved HF prediction when added to traditional CV risk factors.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
National Category
Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
urn:nbn:se:uu:diva-523878 (URN)10.1002/clc.24241 (DOI)001177137700001 ()38402572 (PubMedID)
Available from: 2024-02-25 Created: 2024-02-25 Last updated: 2024-04-12Bibliographically approved
Ghosh, N., Lejonberg, C., Czuba, T., Dekkers, K., Robinson, R., Ärnlöv, J., . . . Smith, J. G. (2024). Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.. Scientific Reports, 14(1), 8933, Article ID 8933.
Open this publication in new window or tab >>Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
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2024 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, no 1, p. 8933-, article id 8933Article in journal (Refereed) Published
Abstract [en]

Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after an overnight fast in 11,309 participants of five population-based Swedish cohorts (50-80 years, 52% women). Metabolite profiles were uniformly generated at a core laboratory (Metabolon Inc.) with untargeted liquid chromatography mass spectrometry and a comprehensive reference library. Analysis of a second sample obtained one year later was conducted in a subset. Of 1629 detected metabolites, 1074 (66%) were detected in all cohorts while only 10% were unique to one cohort, most of which were xenobiotics or uncharacterized. The major classes were lipids (28%), xenobiotics (22%), amino acids (14%), and uncharacterized (19%). The most abundant plasma metabolome components were the major dietary fatty acids and amino acids, glucose, lactate and creatinine. Most metabolites displayed a log-normal distribution. Temporal variability was generally similar to clinical chemistry analytes but more pronounced for xenobiotics. Extensive metabolite-metabolite correlations were observed but mainly restricted to within each class. Metabolites were broadly associated with clinical factors, particularly body mass index, sex and renal function. Collectively, our findings inform the conduct and interpretation of metabolite association and precision medicine studies.

National Category
Health Sciences
Identifiers
urn:nbn:se:uu:diva-526931 (URN)10.1038/s41598-024-59388-7 (DOI)38637659 (PubMedID)
Available from: 2024-04-19 Created: 2024-04-19 Last updated: 2024-04-19
Salihovic, S., Dunder, L., Lind, M. & Lind, L. (2024). Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood. Journal of Mass Spectrometry, 59(2), Article ID e4999.
Open this publication in new window or tab >>Assessing the performance of a targeted absolute quantification isotope dilution liquid chromatograhy tandem mass spectrometry assay versus a commercial nontargeted relative quantification assay for detection of three major perfluoroalkyls in human blood
2024 (English)In: Journal of Mass Spectrometry, ISSN 1076-5174, E-ISSN 1096-9888, Vol. 59, no 2, article id e4999Article in journal (Refereed) Published
Abstract [en]

Isotope dilution ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) is commonly used for trace analysis of polyfluoroalkyl and perfluoroalkyl substances (PFAS) in difficult matrices. Commercial nontargeted analysis of major PFAS where relative concentrations are obtained cost effectively is rapidly emerging and is claimed to provide comparable results to that of absolute quantification using matrix matched calibration and isotope dilution UHPLC–MS/MS. However, this remains to be demonstrated on a large scale. We aimed to assess the performance of a targeted absolute quantification isotope dilution LC–MS/MS assay versus a commercial nontargeted relative quantification assay for detection of three major PFAS in human blood. We evaluated a population-based cohort of 503 individuals. Correlations were assessed using Spearman's rank correlation coefficients (rho). Precision and bias were assessed using Bland–Altman plots. For perfluorooctane sulfonic acid, the median concentrations were 5.10 ng/mL (interquartile range [IQR] 3.50–7.24 ng/mL), the two assays correlated with rho 0.83. For perfluorooctanoic acid, the median concentrations were 2.14 ng/mL (IQR 1.60–3.0 ng/mL), the two assays correlated with rho 0.92. For perfluorohexanesulfonate, the median concentrations were 5.5 ng/mL (IQR 2.50–11.61 ng/mL), the two assays correlated with rho 0.96. The Bland–Altman statistical test showed agreement of the mean difference for the majority of samples (97–98%) between the two assays. Absolute plasma concentrations of PFAS obtained using matrix matched calibration and isotope dilution UHPLC–MS/MS show agreement with relative plasma concentrations from a nontargeted commercial platform by Metabolon. We observed striking consistency between the two assays when examining the associations of the three PFAS with cholesterol, offering additional confidence in the validity of utilizing the nontargeted approach for correlations with various health phenotypes.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
cholesterol, isotope dilution, mass spectrometry, metabolon, nontargeted, PFAS, targeted
National Category
Analytical Chemistry Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:uu:diva-522269 (URN)10.1002/jms.4999 (DOI)001147311100001 ()38263897 (PubMedID)
Funder
Swedish Research Council Formas, 2015-756
Available from: 2024-02-05 Created: 2024-02-05 Last updated: 2024-02-05Bibliographically approved
Vestin, E., Boström, G., Olsson, J., Elgh, F., Lind, L., Kilander, L., . . . Weidung, B. (2024). Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study. Journal of Alzheimer's Disease, 97(4), 1841-1850
Open this publication in new window or tab >>Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study
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2024 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 97, no 4, p. 1841-1850Article in journal (Refereed) Published
Abstract [en]

Background: Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer's disease (AD). Objective: We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation to antiherpesvirus treatment and potential APOE epsilon 4 carriership interaction. Methods: This studywas conducted with 1002 dementia-free 70-year-olds living in Sweden in 2001-2005 who were followed for 15 years. Serum samples were analyzed to detect anti-HSV and anti-HSV-1 immunoglobulin (Ig) G, anti-cytomegalovirus (CMV) IgG, anti-HSV IgM, and anti-HSV and anti-CMV IgG levels. Diagnoses and drug prescriptions were collected from medical records. Cox proportional-hazards regression models were applied. Results: CumulativeADand all-cause dementia incidences were 4% and 7%, respectively. Eighty-two percent of participants were anti-HSV IgG carriers, of whom 6% received anti-herpesvirus treatment. Anti-HSV IgG was associated with a more than doubled dementia risk (fully adjusted hazard ratio = 2.26, p = 0.031). No significant association was found with AD, but the hazard ratio was of the same magnitude as for dementia. Anti-HSV IgM and anti-CMV IgG prevalence, anti-herpesvirus treatment, and anti-HSV and -CMV IgG levels were not associated with AD or dementia, nor were interactions between anti-HSV IgG and APOE epsilon 4 or anti-CMV IgG. Similar results were obtained for HSV-1. Conclusions: HSV (but not CMV) infection may be indicative of doubled dementia risk. The low AD incidence in this cohort may have impaired the statistical power to detect associations with AD.

Place, publisher, year, edition, pages
IOS Press, 2024
Keywords
Aged 80 and over, Alzheimer disease, apolipoprotein E, cognitive disorder, cohort study, cytomegalovirus, dementia, Herpes simplex, human herpesvirus 1, neurocognitive disorder
National Category
Neurology Neurosciences Infectious Medicine Geriatrics
Identifiers
urn:nbn:se:uu:diva-526886 (URN)10.3233/JAD-230718 (DOI)001192064800026 ()38306033 (PubMedID)
Funder
Region UppsalaGun och Bertil Stohnes StiftelseThe Dementia Association - The National Association for the Rights of the DementedSwedish Society of MedicineMärta Lundqvists FoundationStiftelsen Gamla TjänarinnorThe Swedish Brain Foundation
Available from: 2024-04-23 Created: 2024-04-23 Last updated: 2024-04-23Bibliographically approved
Gustafsson, S., Lampa, E., Jensevik, K., Butterworth, A. S., Elmståhl, S., Engström, G., . . . Sundström, J. (2024). Markers of imminent myocardial infarction. Nature Cardiovascular Research
Open this publication in new window or tab >>Markers of imminent myocardial infarction
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2024 (English)In: Nature Cardiovascular Research, E-ISSN 2731-0590Article in journal (Refereed) Epub ahead of print
Abstract [en]

Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction within 6 months after the baseline blood draw. We analyzed 817 proteins and 1,025 metabolites in biobanked blood and 16 clinical variables. Forty-eight proteins, 43 metabolites, age, sex and systolic blood pressure were associated with the risk of an imminent first myocardial infarction. Brain natriuretic peptide was most consistently associated with the risk of imminent myocardial infarction. Using clinically readily available variables, we devised a prediction model for an imminent first myocardial infarction for clinical use in the general population, with good discriminatory performance and potential for motivating primary prevention efforts.

Place, publisher, year, edition, pages
Springer Nature, 2024
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-523069 (URN)10.1038/s44161-024-00422-2 (DOI)
Note

These authors contributed equally: Stefan Gustafsson, Erik Lampa

Available from: 2024-02-13 Created: 2024-02-13 Last updated: 2024-02-13Bibliographically approved
O'Keefe, J. H., Tintle, N. L., Harris, W. S., O'Keefe, E. L., Sala-Vila, A., Attia, J., . . . Mozaffarian, D. (2024). Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. Stroke, 55(1), 50-58
Open this publication in new window or tab >>Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
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2024 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 55, no 1, p. 50-58Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

The effect of marine omega-3 PUFAs on risk of stroke remains unclear.

METHODS:

We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.

RESULTS:

Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.

CONCLUSIONS:

Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

Place, publisher, year, edition, pages
American Heart Association, 2024
Keywords
atrial fibrillation, cerebrovascular disease, fish, fish oil, stroke
National Category
Public Health, Global Health, Social Medicine and Epidemiology Neurology
Identifiers
urn:nbn:se:uu:diva-520257 (URN)10.1161/STROKEAHA.123.044281 (DOI)001128650000001 ()38134264 (PubMedID)
Funder
NIH (National Institutes of Health), T32HL110837
Available from: 2024-01-11 Created: 2024-01-11 Last updated: 2024-03-15Bibliographically approved
Engström, G., Lampa, E., Dekkers, K., Lin, Y.-T., Ahlm, K., Ahlström, H., . . . Sundström, J. (2024). Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications. Eur J Epidemiol
Open this publication in new window or tab >>Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
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2024 (English)In: Eur J Epidemiol, ISSN 1573-7284 Electronic 0393-2990 LinkingArticle in journal (Refereed) Published
Abstract [en]

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Keywords
Atherosclerosis Coronary heart disease Emphysema Spirometry
National Category
Health Sciences
Identifiers
urn:nbn:se:uu:diva-520136 (URN)10.1007/s10654-023-01088-z (DOI)
Note

Engstrom, Gunnar Lampa, Erik Dekkers, Koen Lin, Yi-Ting Ahlm, Kristin Ahlstrom, Hakan Alfredsson, Joakim Bergstrom, Goran Blomberg, Anders Brandberg, John Caidahl, Kenneth Cederlund, Kerstin Duvernoy, Olov Engvall, Jan E Eriksson, Maria J Fall, Tove Gigante, Bruna Gummesson, Anders Hagstrom, Emil Hamrefors, Viktor Hedner, Jan Janzon, Magnus Jernberg, Tomas Johnson, Linda Lind, Lars Lindberg, Eva Mannila, Maria Nilsson, Ulf Persson, Anders Persson, Hans Lennart Persson, Margaretha Ramnemark, Anna Rosengren, Annika Schmidt, Caroline Skoglund Larsson, Linn Skold, C Magnus Swahn, Eva Soderberg, Stefan Toren, Kjell Waldenstrom, Anders Wollmer, Per Zaigham, Suneela Ostgren, Carl Johan Sundstrom, Johan eng ERC-2018-STG-801965/ERC_/European Research Council/International Netherlands 2024/01/02 Eur J Epidemiol. 2024 Jan 2. doi: 10.1007/s10654-023-01088-z.

Available from: 2024-01-11 Created: 2024-01-11 Last updated: 2024-01-11
Xu, S., Larsson, A., Lind, L., Lindskog, C., Ärnlöv, J. & Venge, P. (2024). The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?. Journal of Clinical Medicine, 13(9), Article ID 2629.
Open this publication in new window or tab >>The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
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2024 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 13, no 9, article id 2629Article in journal (Refereed) Published
Abstract [en]

Background: A previous report showed that the urine output of HPLBII-P in patients with diabetes mellitus and SARS-CoV-2 infection was increased as a sign of glomerular dysfunction. The aim of this report was to investigate the relation of the urine output of HPLBII-P to diabetes mellitus in two large community-based elderly populations, i.e., the ULSAM and PIVUS cohorts. Methods: HPLBII-P was measured by an ELISA in the urine of a community-based cohort of 839 men (ULSAM) collected at 77 years of age and in the urine of a community-based cohort of 75-year-old men, n = 387, and women, n = 401 (PIVUS). KIM-1, NGAL, and albumin were measured in urine and cathepsin S and cystatin C in serum. Results: HPLBII-P was significantly raised among males with diabetes in the ULSAM (p < 0.0001) and PIVUS cohorts (p ≤ 0.02), but not in the female cohort of PIVUS. In the female subpopulation of insulin-treated diabetes, HPLBII-P was raised (p = 0.02) as compared to women treated with oral antidiabetics only. In the ULSAM cohort, HPLBII-P was correlated to NGAL, KIM-1, and albumin in urine both in non-DM (all three biomarkers; p < 0.0001) and in DM (NGAL; p = 0.002, KIM-1; p = 0.02 and albumin; p = 0.01). Plasma glucose and HbA1c in blood showed correlations to U-HPLBII-P (r = 0.58, p < 0.001 and r = 0.42, p = 0.004, respectively). U-HPLBII-P and cathepsin S were correlated in the ULSAM group (r = 0.50, p < 0.001). No correlations were observed between U-HPLBII-P and serum creatinine or cystatin C. Conclusions: The urine measurement of HPLBII-P has the potential to become a novel and useful biomarker in the monitoring of glomerular activity in diabetes mellitus.

Place, publisher, year, edition, pages
MDPI, 2024
Keywords
biomarker, nephropathy, podocyte
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-527863 (URN)10.3390/jcm13092629 (DOI)001220542000001 ()38731158 (PubMedID)
Available from: 2024-05-12 Created: 2024-05-12 Last updated: 2024-05-27Bibliographically approved
Projects
PERSISTANT ORGANIC POLLUTANTS (POPs) AND CARDIOVASCULAR DISEASES FROM A GENDER PERSPECTIVE [2008-02214_VR]; Uppsala University
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-2335-8542

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