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Anniko, Matti
Publications (10 of 72) Show all publications
Anniko, M. (2018). Acta Oto-Laryngologica. Acta Oto-Laryngologica, 138(3), 192-193
Open this publication in new window or tab >>Acta Oto-Laryngologica
2018 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 138, no 3, p. 192-193Article in journal, Editorial material (Other academic) Published
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-357043 (URN)10.1080/00016489.2018.1438138 (DOI)000428380600002 ()29532727 (PubMedID)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-08-10Bibliographically approved
Takumida, M., Takumida, H. & Anniko, M. (2017). Gastric-type H+,K+-ATPase in mouse vestibular end organs. Acta Oto-Laryngologica, 137(5), 455-459
Open this publication in new window or tab >>Gastric-type H+,K+-ATPase in mouse vestibular end organs
2017 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 137, no 5, p. 455-459Article in journal (Refereed) Published
Abstract [en]

Conclusion: Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+ circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac. Objective: To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs. Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase alpha and beta in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry. Results: In the vestibular end organs, H+,K+-ATPase alpha and beta were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.

Place, publisher, year, edition, pages
Taylor & Francis, 2017
Keywords
Hydrogen, potassium-adenosine triphosphatase, vestibular end organ, immunohistochemistry
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-322674 (URN)10.1080/00016489.2016.1245865 (DOI)000400167100001 ()27768854 (PubMedID)
Available from: 2017-05-30 Created: 2017-05-30 Last updated: 2017-05-30Bibliographically approved
Takumida, M., Takumida, H. & Anniko, M. (2016). Localization of histamine (H-1, H-2, H-3 and H-4) receptors in mouse inner ear. Acta Oto-Laryngologica, 136(6), 537-544
Open this publication in new window or tab >>Localization of histamine (H-1, H-2, H-3 and H-4) receptors in mouse inner ear
2016 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, no 6, p. 537-544Article in journal (Refereed) Published
Abstract [en]

Conclusion: The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear.

Objective: To analyse the presence of histamine receptors in the normal mouse inner ear.

Methods: CBA/J mice were used in this study. The localization of H1R, H2R, H3R, and H4R in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion, and endolymphatic sac, was studied by real-time PCR and immunohistochemistry.

Results: The mRNA for each receptor sub-type was detected in the inner ear. In the immunohistochemical study, the organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory epithelium, and endolymphatic sac cells showed an immunofluorescent reaction to all histamine receptors.

Keywords
Histamine, histamine receptor, inner ear, mouse, RT-PCR, immunohistochemistry
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-297250 (URN)10.3109/00016489.2015.1136433 (DOI)000375483400001 ()26854127 (PubMedID)
Available from: 2016-06-29 Created: 2016-06-22 Last updated: 2017-11-28Bibliographically approved
Takumida, M., Takumida, H., Katagiri, Y. & Anniko, M. (2016). Localization of sirtuins (SIRT1-7) in the aged mouse inner ear. Acta Oto-Laryngologica, 136(2), 120-131
Open this publication in new window or tab >>Localization of sirtuins (SIRT1-7) in the aged mouse inner ear
2016 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, no 2, p. 120-131Article in journal (Refereed) Published
Abstract [en]

Conclusion: The expression of sirtuin in vestibular end organs and cochlea responds differently to age-related changes. Down-regulation of SIRT1, 3, and 5 in the cochlea may weaken the protective activity regarding degeneration of the organ of Corti as well as of spiral ganglion cells, resulting in the development of age-related hearing loss. An increase in SIRT 1, 4, or 5 in vestibular tissue could indicate an increased need of detoxification of reactive oxygen species and an increased anti-ageing potential. Objective: To analyse the expression of sirtuins (SIRT1-7) in the normal young and old mouse inner ears. Methods: Young (8 weeks) and old (22 months) CBA/J mice were used in this study. Localization of SIRT1-7 in the inner ear, i.e. cochlea, vestibular end organs, and vestibular ganglion, was investigated using real-time PCR and immunohistochemistry. Results: In the vestibular end organs, the expression of SIRT1, 2, 4, 5 (both mRNA and protein), SIRT6, and 7 (only mRNA) was found to be increased, while a slightly decreased immunoreactivity was observed in SIRT3. In the cochlea, the expression of SIRT1, 3, and 5 (both mRNA and protein) was decreased in the old mice, whereas no noticeable difference was observed regarding SIRT2, 4, 6, or 7.

Keywords
Sirtuin, inner ear, mouse, ageing, presbycusis
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-275530 (URN)10.3109/00016489.2015.1093172 (DOI)000367596500002 ()26472659 (PubMedID)
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2017-11-30Bibliographically approved
Zhang, X., Xu, X., Ma, W., Zhang, Q., Tong, B., Yu, H., . . . Duan, M. (2015). A clinical study of sudden deafness. Acta Oto-Laryngologica, 135(10), 1030-1035
Open this publication in new window or tab >>A clinical study of sudden deafness
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2015 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, no 10, p. 1030-1035Article in journal (Refereed) Published
Abstract [en]

Conclusions: Sudden Sensorineural Hearing Loss (SSHL) was commonly seen in middle aged people. Tinnitus was reported by 87.2% of the patients, and dizziness or vertigo were reported by 48.5%. The most common concomitant disorder of SSHL was hyperlipidemia. Objective: A retrospective register study with SSHL was performed in Xi'an, China, from 2000-2009. Results: Of 617 inpatients, the right ear was affected in 267 cases, the left ears in 282 cases, and both ears in 68 cases. The most common age of patients was 41-50 years. There were 20.4% SSHL patients with hypertension, coronary artery disease, or diabetes, and 49.6% patients with hyperlipidemia. Auditory Brainstem Responses (ABR) were performed in 460 patients (504 ears) before treatment, and the ABR threshold of 56.4% ears was >90 dB. The constituent ratio of patients with an ABR threshold over 90 dB was greater in the vertigo group than the other group. CT and/or MRI scans were available in 277 cases, of which 40 cases (14.4%) were abnormal.

Keywords
Sudden sensorineural hearing loss (SSHL), inner ear, ABR, vertigo
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-265636 (URN)10.3109/00016489.2015.1060629 (DOI)000361294200010 ()26106936 (PubMedID)
Funder
Stockholm County CouncilNIH (National Institute of Health), R01DC004554
Available from: 2015-11-04 Created: 2015-11-02 Last updated: 2017-12-01Bibliographically approved
Takumida, M., Takumida, H. & Anniko, M. (2014). Localization of sirtuins in the mouse inner ear. Acta Oto-Laryngologica, 134(4), 331-338
Open this publication in new window or tab >>Localization of sirtuins in the mouse inner ear
2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 134, no 4, p. 331-338Article in journal (Refereed) Published
Abstract [en]

Conclusion: It is suggested that SIRT1 and 3, and probably SIRT4 and 5, play an important role in the neuroprotection of the inner ear. SIRT2 may be related to neuroprotection and myelin sheath formation, while SIRT6 seems to have a significant role in maintaining the energy balance by metabolic regulation. Objective: To analyze the expression of sirtuins (SIRT1-7) in the normal mouse inner ear. Methods: CBA/J mice were used for this study. The localization of SIRT1-7 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated using real-time PCR and immunohistochemistry. Results: We found high levels of mRNA of all seven sirtuins in the inner ear. In the immunohistochemical study, SIRT1-7 were abundant in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac.

Keywords
Aquaporins, vasopressin receptor, immunohistochemistry
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-223860 (URN)10.3109/00016489.2013.861928 (DOI)000333037200001 ()
Available from: 2014-05-09 Created: 2014-04-28 Last updated: 2017-12-05Bibliographically approved
Katagiri, Y., Takumida, M., Hirakawa, K. & Anniko, M. (2014). Long-term administration of vasopressin can cause Meniere's disease in mice. Acta Oto-Laryngologica, 134(10), 990-1004
Open this publication in new window or tab >>Long-term administration of vasopressin can cause Meniere's disease in mice
2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 134, no 10, p. 990-1004Article in journal (Refereed) Published
Abstract [en]

Conclusion: A new murine model of Meniere's disease has been developed, based on long-term administration of vasopressin. Induction of vestibular dysfunction in the present animal model can cause additional stress, by reducing inner ear blood flow. Latanoprost, a selective agonist for the FP prostanoid receptor, may become a new remedy for Meniere's disease. Objective: The purpose of this study was to develop a more suitable animal model, with a closer resemblance to the pathophysiological process in Meniere's disease. Methods: Adult CBA/J or ICR mice were treated by subcutaneous injection of vasopressin for 5 days up to 8 weeks. Morphological analyses were performed of the cochlea, vestibular end organs and endolymphatic sac. The effect of latanoprost on the development of endolymphatic hydrops was also examined. Results: All experimental animals showed mild to moderate endolymphatic hydrops, increasing in severity as the vasopressin treatment was prolonged. Animals treated with vasopressin for 8 weeks showed severe endolymphatic hydrops with partial loss of outer hair cells and spiral ganglion cells. These animals also had a reversible vestibular dysfunction following intratympanic injection of epinephrine. Latanoprost inhibited the development of endolymphatic hydrops caused by vasopressin.

Keywords
Endolymphatic hydrops, vestibular dysfunction, latanoprost
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-235303 (URN)10.3109/00016489.2014.902989 (DOI)000342204900002 ()25131393 (PubMedID)
Available from: 2014-11-06 Created: 2014-10-30 Last updated: 2017-12-05Bibliographically approved
Gao, C., Li, X., Tong, B., Wu, K., Liu, Y., Anniko, M. & Duan, M. (2014). Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma. Acta Oto-Laryngologica, 134(9), 959-963
Open this publication in new window or tab >>Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma
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2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 134, no 9, p. 959-963Article in journal (Refereed) Published
Abstract [en]

Conclusions: Increased expression of Dicer may be a prognostic biomarker for patients with laryngeal squamous cell carcinoma (LSCC). Objectives: Recent studies have shown that many microRNAs (miRNAs) play an important role in the development and progression of human cancers. Dicer, one of the most important enzymes of the miRNA machinery, performs the final step of biogenesis of miRNAs. This study aimed to investigate the impact of Dicer expression on patient survival in human LSCC. Methods: We detected the expression of Dicer in larynx tissue specimens from 76 LSCC samples and 26 polyps by immunohistochemistry. The clinicopathological and prognostic significance of Dicer expression was investigated in LSCC. Results: Our data showed that the expression of Dicer was significantly higher in the LSCC than in the polyp tissue specimens. Moreover, the expression level of Dicer was significantly associated with the pTNM stage and tumor lymph node metastasis. Kaplan-Meier survival analyses revealed a strong association between tumor Dicer expression and the survival of the patients with LSCC.

Keywords
Larynx, cancer, metastasis, biomarker
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:uu:diva-231978 (URN)10.3109/00016489.2014.920962 (DOI)000340462000011 ()
Available from: 2014-09-15 Created: 2014-09-12 Last updated: 2017-12-05Bibliographically approved
Lidian, A., Linder, B., Anniko, M. & Nordang, L. (2013). BDNF as otoprotectant in toxin-induced hearing loss. Acta Oto-Laryngologica, 133(1), 4-11
Open this publication in new window or tab >>BDNF as otoprotectant in toxin-induced hearing loss
2013 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 133, no 1, p. 4-11Article in journal (Refereed) Published
Abstract [en]

Conclusion: Brain-derived neurotrophic factor (BDNF) can prevent auditory brainstem response (ABR) threshold shift changes caused by Pseudomonas aeruginosa exotoxin A (PaExoA). Objective: Peptides of the neurotrophin family are known to prevent neuronal death during embryonic development by interacting with specific membrane receptors. The purpose of this study was to investigate whether a single dose of BDNF is an effective protectant against toxic effects of PaExoA-induced ABR threshold shifts. Materials and Methods: Eight groups of Sprague-Dawley rats were used. There were five control groups (n = 20) as follows. Group A (n = 4) received NaCl solution; group B (n = 3) received 4 mu g BDNF; group C (n = 4) received 1 mu g/20 mu l PaExoA; group D (n = 4) received 2 mu g/20 mu l PaExoA; groupE (n = 5) received 10 mu g/20 mu l PaExoA injected into the round window niche. Three treatment groups (n = 13) received a single dose of PaExoA and 4 mu g of BDNF simultaneously. Group 1 (n = 3) received 1 mu g/20 mu l PaExoA + 4 mu g of BDNF; group 2 (n = 5) received 2 mu g/20 mu l PaExoA + 4 mg BDNF; group 3 (n = 5) received 10 mu g/20 mu l PaExoA+ 4 mu g BDNF. ABR was used to measure efficacy by analyzing threshold shifts before and after injections. Results: A single dose of BDNF prevented changes in ABR thresholds following exposure to increasing concentrations of PaExoA injected into the middle ear.

Keywords
Auditory brainstem response, Brain-derived neurotrophic factor, Pseudomonas aeruginosa exotoxin A, cochlea, round window membrane, rat
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-192429 (URN)10.3109/00016489.2012.712216 (DOI)000312525800001 ()
Available from: 2013-01-24 Created: 2013-01-21 Last updated: 2017-12-06Bibliographically approved
Takano, S., Iguchi, H., Sakamoto, H., Yamane, H. & Anniko, M. (2013). Blockage pattern of longitudinal flow in Meniere's disease. Acta Oto-Laryngologica, 133(7), 692-698
Open this publication in new window or tab >>Blockage pattern of longitudinal flow in Meniere's disease
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2013 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 133, no 7, p. 692-698Article in journal (Refereed) Published
Abstract [en]

Conclusion: In the present study, classification of the patterns of 3D CT images of the ductus reuniens (reuniting duct) (RD), saccular duct (SD), and endolymphatic sinus (ES) gave more precise information for assessing the pathological condition of Meniere's disease (MD) than our previous study. Objective: This study attempted to provide more detailed information on MD by classifying the patterns of 3D CT images of the RD, SD, and ES in patients with MD. Methods: We examined the ears of 62 patients with definitely diagnosed unilateral MD based on the criteria of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) using 3D CT. The 3D CT images of bony grooves of RD, SD, and ES (BRD, BSD, and BES) were classified into patterns according to aspects of their patency. Results: BRD could be classified into six types by assessing their patency defined using the criteria in this study. In the ears on the affected side of patients with MD, the BRD, BSD, and BES lost continuity in 3D CT images along their bony routes and were significantly different from normal healthy ears (p<0.01). There were no significant differences among each stage of MD in the distributions of BRD and BES except for BSD.

Keywords
Ductus reuniens, saccular duct, endolymphatic sinus, saccule, endolymphatic hydrops, otoconia, stage, CT image
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-204976 (URN)10.3109/00016489.2013.771409 (DOI)000321233700003 ()
Available from: 2013-08-16 Created: 2013-08-13 Last updated: 2017-12-06Bibliographically approved
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