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Abdsaleh, Shahin
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Publications (10 of 11) Show all publications
Hersi, A.-F., Eriksson, S., Ramos, J., Abdsaleh, S., Wärnberg, F. & Karakatsanis, A. (2019). A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery. European Journal of Surgical Oncology, 45(4), 544-549
Open this publication in new window or tab >>A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery
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2019 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 45, no 4, p. 544-549Article in journal (Refereed) Published
Abstract [en]

Background: Surgery for non-palpable breast cancer may often be a challenging procedure. Recently, a magnetic seed (Magseed®) used for tumour localization has been developed. Superparamagnetic iron oxide nanoparticles (SPIO) for sentinel lymph node (SN) detection is a novel tracer that may be injected up to four weeks preoperatively. This study is the first combining the magnetic seed and SPIO.

Material and methods: Patients planned for breast conserving surgery and SN-biopsy (SNB) were recruited from two units in Sweden. Patients underwent lesion localization with Magseed® and SPIO injection (Magtrace™) by the breast radiologist in the preoperative period. Feasibility of successful lesion localization and excision together with a successful SNB detection was evaluated. Seed migration, number of SNs, specimen volume and calculated resection ratio (CRR) were reported.A survey of the physicians’ experience was conducted.

Results: Localization was performed at a median of three days before surgery (range 0–25). All 32 patients underwent microscopically radical resection with a CRR of 1.49. No seed migration was noticed. SNB was successful in all patients. A median of two SNs was retrieved. Radiologists and surgeons reported the procedure easy to learn and outperformed guidewire localization in terms of localization and excision time. They thought the technique facilitated planning localization and surgery.

Conclusions: The combined magnetic technique provided accuracy in tumour localization and SN detection without excess tissue excision and with promising results for flexibility in delivery of care. Larger studies are needed to confirm these findings.

Keywords
Breast cancer, Sentinel node biopsy, Occult lesion localization, Superparamagnetic iron oxide nanoparticles, Magnetic seed marker, Breast conserving surgery
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-382650 (URN)10.1016/j.ejso.2018.10.064 (DOI)000464086700007 ()30401506 (PubMedID)
Available from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved
Wärnberg, F., Stigberg, E., Obondo, C., Olofsson, H., Abdsaleh, S., Wärnberg, M. & Karakatsanis, A. (2019). Long-Term Outcome After Retro-Areolar Versus Peri-Tumoral Injection of Superparamagnetic Iron Oxide Nanoparticles (SPIO) for Sentinel Lymph Node Detection in Breast Cancer Surgery.. Annals of Surgical Oncology, 26(5), 1247-1253
Open this publication in new window or tab >>Long-Term Outcome After Retro-Areolar Versus Peri-Tumoral Injection of Superparamagnetic Iron Oxide Nanoparticles (SPIO) for Sentinel Lymph Node Detection in Breast Cancer Surgery.
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2019 (English)In: Annals of Surgical Oncology, ISSN 1068-9265, E-ISSN 1534-4681, Vol. 26, no 5, p. 1247-1253Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/OBJECTIVE: SPIO is effective in sentinel node (SN) detection. No nuclear medicine department is needed, and no allergic reactions have occurred. This study aimed to compare retro-areolar and peri-tumoral SPIO injections regarding skin staining, detection rates and number of SNs.

METHODS: Data on staining size, intensity and cosmetic outcome (0-5; 0 = no problem) were collected by telephone interviews with 258 women undergoing breast conservation. SN detection and the number of SNs were prospectively registered in 332 women.

RESULTS: After retro-areolar and peri-tumoral injections, 67.3% and 37.8% (p < 0.001) developed skin staining, with remaining staining in 46.2 vs. 9.4% after 36 months (p < 0.001). Initial mean size was 16.3 vs. 6.8 cm (p < 0.001) and after 36 months, 6.6 vs. 1.8 cm2 (p < 0.001). At 75.1% of 738 interviews, staining was reported paler. After retro-areolar injections, cosmetic outcome scored worse for 2 years. The mean (median) scores were 1.3(0) vs. 0.5(0) points, and 0.2(0) vs. 0.1(0) points, at 12 and 36 months, respectively. Overall detection rates were 98.3% and 97.4% (p = 0.43) and the number of SNs 1.35 vs. 1.57 (p = 0.02) after retro-areolar and peri-tumoral injections. Injection, regardless of type, 1-27 days before surgery increased detection rates with SPIO, 98.0% vs. 94.2% (p = 0.06) ,and SN numbers, 1.56 vs. 1.27 (p = 0.003).

CONCLUSION: SPIO is effective and facilitates planning for surgery. Peri-tumoral injection reduced staining with a similar detection rate. Staining was not considered a cosmetic problem among most women. Injecting SPIO 1-27 days before surgery increased the detection rate by 3.8% and increased the number of SNs by 0.3.

National Category
Clinical Laboratory Medicine
Research subject
Pathology
Identifiers
urn:nbn:se:uu:diva-380893 (URN)10.1245/s10434-019-07239-5 (DOI)000464726300019 ()30830536 (PubMedID)
Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-05-09Bibliographically approved
Karakatsanis, A., Obondo, C., Abdsaleh, S., Hersi, A.-F., Eriksson, S. & Wärnberg, F. (2018). Optimisation of breast MRI compatibility after sentinel node biopsy with paramagnetic tracers [Letter to the editor]. European Journal of Surgical Oncology, 44(5), 731-732
Open this publication in new window or tab >>Optimisation of breast MRI compatibility after sentinel node biopsy with paramagnetic tracers
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2018 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 44, no 5, p. 731-732Article in journal, Letter (Other academic) Published
Keywords
Breast cancer, Sentinel node biopsy, Superparamagnetic iron oxide nanoparticles, MRI, Breast conservation
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-361433 (URN)10.1016/j.ejso.2018.01.241 (DOI)000433399800027 ()29478740 (PubMedID)
Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved
Obondo, C., Karakatsanis, A., Eriksson, S., Hersi, A. F., Pistiolis, L., Abdsaleh, S., . . . Wärnberg, F. (2018). SentiDose - A dose optimizing study with SiennaXP, a superparamagnetic iron oxide for sentinel node detection. Paper presented at 11th European Breast Cancer Conference (EBCC), MAR 21-23, 2018, Barcelona, SPAIN. European Journal of Cancer, 92, S79-S79
Open this publication in new window or tab >>SentiDose - A dose optimizing study with SiennaXP, a superparamagnetic iron oxide for sentinel node detection
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2018 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 92, p. S79-S79Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2018
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-357179 (URN)000429103100206 ()
Conference
11th European Breast Cancer Conference (EBCC), MAR 21-23, 2018, Barcelona, SPAIN
Available from: 2018-08-14 Created: 2018-08-14 Last updated: 2018-08-14Bibliographically approved
Zhou, W., Sollie, T., Tot, T., Blomqvist, C., Abdsaleh, S., Liljegren, G. & Wärnberg, F. (2017). Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort. International Journal of Breast Cancer, Article ID 4351319.
Open this publication in new window or tab >>Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort
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2017 (English)In: International Journal of Breast Cancer, ISSN 2090-3170, E-ISSN 2090-3189, article id 4351319Article in journal (Refereed) Published
Abstract [en]

Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabar. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER-and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 (0.13-1.08) and 0.82 (0.29-2.27), respectively, and the HR of an in situ IBE was 0.90 (0.41-1.95) and 1.60 (0.75-3.39), respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-319323 (URN)10.1155/2017/4351319 (DOI)000394652400001 ()
Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-11-29Bibliographically approved
Karakatsanis, A., Olofsson, H. M., Eriksson, S., Andersson, Y., Bergkvist, L. A., Mohammed, I., . . . Wärnberg, F. (2017). SentiNot: A way to avoid sentinel node biopsy (SNB) in patients with a preoperative diagnosis of ductal cancer in situ (DCIS). Paper presented at San Antonio Breast Cancer Symposium, DEC 06-10, 2016, San Antonio, TX. Cancer Research, 77
Open this publication in new window or tab >>SentiNot: A way to avoid sentinel node biopsy (SNB) in patients with a preoperative diagnosis of ductal cancer in situ (DCIS)
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2017 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 77Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Univ Uppsala Hosp, Sect Endocrine & Breast Surg, Uppsala, Sweden. Univ Uppsala Hosp, Uppsala, Sweden. Vastmanland Cty Hosp, Vasteras, Vasteras, Sweden. Uppsala Clin Res Ctr, Uppsala, Sweden. Kalmar Cty Hosp, Sect Breast Surg, Kalmar, Sweden. Univ Uppsala Hosp, Inst Radiol Oncol & Radiotherapy, Uppsala, Sweden. Norrlands Univ Hosp, Umea, Sweden.: AMER ASSOC CANCER RESEARCH, 2017
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-320979 (URN)10.1158/1538-7445.SABCS16-P2-01-19 (DOI)000397999000308 ()
Conference
San Antonio Breast Cancer Symposium, DEC 06-10, 2016, San Antonio, TX
Available from: 2017-04-27 Created: 2017-04-27 Last updated: 2017-04-27Bibliographically approved
Hellquist, B. N., Duffy, S. W., Abdsaleh, S., Björneld, L., Bordas, P., Tabar, L., . . . Jonsson, H. (2011). Effectiveness of Population-Based Service Screening With Mammography for Women Ages 40 to 49 Years Evaluation of the Swedish Mammography Screening in Young Women (SCRY) Cohort. Cancer, 117(4), 714-722
Open this publication in new window or tab >>Effectiveness of Population-Based Service Screening With Mammography for Women Ages 40 to 49 Years Evaluation of the Swedish Mammography Screening in Young Women (SCRY) Cohort
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2011 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 117, no 4, p. 714-722Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The effectiveness of mammography screening for women ages 40 to 49 years still is questioned, and few studies of the effectiveness of service screening for this age group have been conducted. METHODS: Breast cancer mortality was compared between women who were invited to service screening at ages 40 to 49 years (study group) and women in the same age group who were not invited during 1986 to 2005 (control group). Together, these women comprise the Mammography Screening of Young Women (SCRY) cohort, which includes all Swedish counties. A prescreening period was defined to facilitate a comparison of mortality in the absence of screening. The outcome measure was refined mortality, ie, breast cancer death for women who were diagnosed during follow-up at ages 40 to 49 years. Relative risks (RRs) with 95% confidence intervals (Os) were estimated. RESULTS: There was no significant difference in breast cancer mortality during the prescreening period. During the study period, there were 803 breast cancer deaths in the study group (7.3 million person-years) and 1238 breast cancer deaths in the control group (8.8 million person-years). The average follow-up was 16 years. The estimated RR for women who were invited to screening was 0.74 (95% Cl, 0.66-0.83), and the RR for women who attended screening was 0.71 (95% CI, 0.620.80). CONCLUSIONS: In this comprehensive study, mammography screening for women ages 40 to 49 years was efficient for reducing breast cancer mortality.

Keywords
mammography, screening, breast cancer, mortality
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-149048 (URN)10.1002/cncr.25650 (DOI)000286966500009 ()20882563 (PubMedID)
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2017-12-11Bibliographically approved
Abdsaleh, S., Wärnberg, F., Azavedo, E., Lindgren, P. G. & Amini, R.-M. (2008). Comparison of core needle biopsy and surgical specimens in malignant breast lesions regarding histological features and hormone receptor expression. Histopathology, 52(6), 773-775
Open this publication in new window or tab >>Comparison of core needle biopsy and surgical specimens in malignant breast lesions regarding histological features and hormone receptor expression
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2008 (English)In: Histopathology, ISSN 0309-0167, E-ISSN 1365-2559, Vol. 52, no 6, p. 773-775Article in journal (Refereed) Published
National Category
Clinical Laboratory Medicine
Research subject
Pathology
Identifiers
urn:nbn:se:uu:diva-170549 (URN)10.1111/j.1365-2559.2008.03014.x (DOI)18393972 (PubMedID)
Available from: 2012-03-12 Created: 2012-03-12 Last updated: 2017-12-07Bibliographically approved
Abdsaleh, S., Azavedo, E. & Lindgren, P. G. (2004). Ultrasound-guided large needle core biopsy of the axilla.. Acta Radiol, 45(2), 193-6
Open this publication in new window or tab >>Ultrasound-guided large needle core biopsy of the axilla.
2004 (English)In: Acta Radiol, ISSN 0284-1851, Vol. 45, no 2, p. 193-6Article in journal (Other scientific) Published
Keywords
Adult, Aged, Aged; 80 and over, Axilla, Biopsy; Needle/*methods, Female, Human, Lymph Nodes/*pathology, Male, Middle Aged, Ultrasonography; Interventional
Identifiers
urn:nbn:se:uu:diva-67364 (URN)15191105 (PubMedID)
Available from: 2005-09-26 Created: 2005-09-26 Last updated: 2011-01-12
Åström, G., Abdsaleh, S., Brenning, G. C. & Ahlström, H. (2001). MR imaging of primary, secondary, and mixed forms of lymphedema. Acta Radiologica, 42(4), 409-416
Open this publication in new window or tab >>MR imaging of primary, secondary, and mixed forms of lymphedema
2001 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 42, no 4, p. 409-416Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

To describe the pathological features and assess the diagnostic information of different MR sequences in patients with primary, secondary, and mixed (phlebo-, lipophlebo-, or lipolymphedema) forms of lymphedema of the lower leg.

MATERIAL AND METHODS:

In 26 patients with clinical diagnoses of primary (n=10), pure secondary (n=4), mixed (n=9) and combined secondary and mixed forms of lymphedema (n=3), MR imaging was performed with coronal and axial T1 SE, T2 TSE, fat-suppressed (SPIR) T2 sequences and axial T1 SE after i.v. injection of Gd-DTPA.

RESULTS:

In 24 patients there was a honeycomb pattern in the subcutis with a signal intensity corresponding to fluid (n=11), fibrosis (n=3), or both (n=10). Five patients with primary lymphedema showed subfascial fluid accumulation. Dermal edema was noted in 23 patients. Fat or edema components in the muscles were mostly seen in patients with phlebolymphedema. The honeycomb pattern was best seen on coronal T1 images, and fluid accumulations on axial SPIR-T2 images. Fibrosis was only assessible from the T2 TSE sequence. Gd-DTPA did not improve the diagnostic information.

CONCLUSION:

For evaluation of lymphedema and its mixed forms, an axial T2-weighted SPIR sequence in conjunction with a coronal T1 SE sequence are sufficient.

Keywords
Adult, Aged, Contrast Media, Female, Fibrosis, Gadolinium DTPA/diagnostic use, Humans, Leg/pathology, Lymphedema/*diagnosis/etiology, Magnetic Resonance Imaging, Male, Middle Aged, Research Support; Non-U.S. Gov't
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-73098 (URN)11442467 (PubMedID)
Available from: 2008-06-11 Created: 2008-06-11 Last updated: 2017-12-14Bibliographically approved
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