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Karlström, Brita
Alternative names
Publications (10 of 35) Show all publications
Karlsson, M., Olsson, E., Becker, W., Karlström, B., Cederholm, T. & Sjögren, P. (2017). Ability to predict resting energy expenditure with six equations compared to indirect calorimetry in octogenarian men. Experimental Gerontology, 92, 52-55
Open this publication in new window or tab >>Ability to predict resting energy expenditure with six equations compared to indirect calorimetry in octogenarian men
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2017 (English)In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 92, p. 52-55Article in journal (Refereed) Published
Abstract [en]

The accuracy of predictive equations for calculating resting energy expenditure (REE) in elderly people has been questioned. Aging is associated with progressive declines in REE, which partly is explained by loss of fat free mass (FFM). Against this background we aimed to identify the most accurate predictive equation for REE in octogenarian men, taking body composition into account and using indirect calorimetry as reference value. REE was measured in 22 men (mean age 82.6 +/- 0.3 years) and compared with six predictive equations: two based on FFM and four based on body weight, height and/or age. FFM was derived from Dual-energy X-ray absorptiometry analyses. Spearman's rank correlations showed a moderate to high positive monotonic correlation (r = 0.62 to 0.79) between measured and calculated REE (all p < 0.005).The mean calculated REE was significantly different from measured REE for all equations except Mifflin-St Jeor. A calculated REE within 10% of measured REE was considered acceptable and the equations of Mifflin-St Jeor, WHO and Harris-Benedict captured 64%, 50% and 45% of the participant, respectively. The Mifflin-St Jeor equation had the lowest root mean square error (138 kcal), followed by the equation by Harris-Benedict (189 kcal) and WHO (220 kcal). The equations from Luhrmann, Henry and Cunningham predicted REE rather poorly in our study subjects, with e.g. <40% of the individuals within 10% of measured REE. Our results indicate that the Mifflin-St Jeor equation (using FFM) is the most accurate equation estimating REE in these octogenarian men. Harris-Benedict or WHO equations are potential alternatives if information on FFM is unavailable, although their accuracy on an individual level is limited.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD, 2017
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-323020 (URN)10.1016/j.exger.2017.03.013 (DOI)000400530400009 ()28323025 (PubMedID)
Funder
Swedish Research Council, K2010-70X-2141401-3, 2011-2427
Available from: 2017-06-09 Created: 2017-06-09 Last updated: 2018-02-22Bibliographically approved
Byberg, L., Olsson, E., Karlström, B., Cederholm, T., Melhus, H., Sjögren, P. & Kilander, L. (2017). Reply to WB Grant [Letter to the editor]. American Journal of Clinical Nutrition, 106(2), 700-701
Open this publication in new window or tab >>Reply to WB Grant
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2017 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 106, no 2, p. 700-701Article in journal, Letter (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-334418 (URN)10.3945/ajcn.117.160168 (DOI)000406672300035 ()28765386 (PubMedID)
Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2018-08-24Bibliographically approved
Byberg, L., Olsson, E., Karlström, B., Cederholm, T., Melhus, H., Sjögren, P. & Kilander, L. (2017). Reply to Y Mao and H Yu. [Letter to the editor]. American Journal of Clinical Nutrition, 106(2), 698-699
Open this publication in new window or tab >>Reply to Y Mao and H Yu.
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2017 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 106, no 2, p. 698-699Article in journal, Letter (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-334420 (URN)10.3945/ajcn.117.156752 (DOI)000406672300033 ()28765384 (PubMedID)
Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2018-08-24Bibliographically approved
Olsson, E., Byberg, L., Karlström, B., Cederholm, T., Melhus, H., Sjögren, P. & Kilander, L. (2017). Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men. American Journal of Clinical Nutrition, 105(4), 936-943
Open this publication in new window or tab >>Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men
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2017 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 105, no 4, p. 936-943Article in journal (Refereed) Published
Abstract [en]

Background: Vitamin D has been implicated as being important for maintaining cognitive function in old age. Results from longitudinal studies examining the association of vitamin D with incident dementia and cognitive impairment have been inconsistent. Objective: We investigated the relation between vitamin D, assessed in 3 different ways, and the risk of dementia. Design: We measured plasma 25-hydroxyvitamin D [25(OH) D] with the use of high-performance liquid chromatography-mass spectrometry, assessed dietary vitamin D intake with the use of 7-d dietary records, and created a vitamin D-synthesis genetic risk score (GRS) at baseline (1991-1995) in a cohort of 1182 Swedish men (mean age: 71 y). In a maximum of 18 y (median: 12 y) of follow-up, 116 men developed Alzheimer disease, 64 men developed vascular dementia, and 250 men developed all-cause dementia. An additional 80 men declined in cognitive function as assessed with the use of the Mini-Mental State Examination. Adjusted HRs and ORs were calculated with the use of Cox and logistic regressions. Results: The mean +/- SD plasma 25(OH) D concentration was 68.7 +/- 19.1 nmol/L. Plasma 25(OH) D, dietary vitamin D intake, and vitamin D-synthesis GRS were not associated with any cognitive outcomes (crude and adjusted HRs and ORs were similar to 1.0 for all continuous exposures). The adjusted HR for all-cause dementia was 0.88 (95% CI: 0.59, 1.31) in men with plasma 25(OH) D concentrations <= 50 compared with >75 nmol/L. The adjusted HR for all-cause dementia was 0.92 (95% CI: 0.63, 1.32) for the lowest compared with highest tertiles of vitamin D intake. The adjusted HR for the continuous GRS for all-cause dementia was 1.04 (95% CI: 0.91, 1.19). Conclusion: In this cohort study, we show that there is no association between baseline vitamin D status and long-term risk of dementia or cognitive impairment over an 18-y period of time.

Place, publisher, year, edition, pages
AMER SOC NUTRITION-ASN, 2017
Keywords
Alzheimer disease, cognitive impairment, cohort, dementia, Mendelian randomization, vascular dementia, vitamin D, 25-hydroxyvitamin D
National Category
Nutrition and Dietetics Geriatrics
Identifiers
urn:nbn:se:uu:diva-322217 (URN)10.3945/ajcn.116.141531 (DOI)000398941700020 ()28202477 (PubMedID)
Funder
Swedish Research Council, K2013-69x-21414-04-3
Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2018-08-24Bibliographically approved
Järvi, A., Karlström, B., Vessby, B. & Becker, W. (2016). Increased intake of fruits and vegetables in overweight subjects: effects on body weight, body composition, metabolic risk factors and dietary intake. British Journal of Nutrition, 115(10), 1760-1768
Open this publication in new window or tab >>Increased intake of fruits and vegetables in overweight subjects: effects on body weight, body composition, metabolic risk factors and dietary intake
2016 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 115, no 10, p. 1760-1768Article in journal (Refereed) Published
Abstract [en]

A diet rich in fruits and vegetables has been associated with several health benefits. However, the effects on body weight (BW) and metabolic markers are not fully known. The present study investigated the effects of increased intake of fruits and vegetables in overweight and obese men and women on dietary habits, anthropometry and metabolic control. In a 16-week controlled intervention, thirty-four men and thirty-four women aged 35-65 years (BMI>27 kg/m(2)) were randomised to an intervention (IN) or a reference (RG) group. All participants received general dietary advice, and subjects in the IN group received fruits and vegetables for free, of which >= 500 g had to be eaten daily. BW, waist circumference (WC), sagittal abdominal diameter (SAD), plasma insulin, blood glucose, glycated Hb (HbA1c), serum lipids, blood pressure, plasminogen activator inhibitor-1 activity, urinary isoprostane (iso-8-PGF 2 alpha) and serum carotenoids were measured. Diet was assessed using 3-d weighed food records. In all, thirty subjects in the IN group and thirty-two in the RG group completed the intervention. Intake of fruits and vegetables doubled in the IN group, whereas intake of fruits increased in the RG group. Serum a-and beta-carotene concentrations and intakes of folate and vitamin C increased significantly in the IN group. Energy intake, BW, WC and SAD decreased significantly in both groups. Supine systolic blood pressure decreased significantly in the IN group, with no between-group differences. No significant changes were observed for other metabolic markers. Provision of fruits and vegetables led to substantially increased intakes, with subsequent favourable changes in anthropometry and insulin levels, which tended to be more pronounced in the IN group. The observed improvements may, in combination with improved nutritional markers, have health benefits in the long term.

Keywords
Fruits, Vegetables, Body weight, Food intakes, Metabolic markers
National Category
Health Sciences
Identifiers
urn:nbn:se:uu:diva-302243 (URN)10.1017/S0007114516000970 (DOI)000376675200007 ()26996228 (PubMedID)
External cooperation:
Available from: 2016-09-01 Created: 2016-08-31 Last updated: 2017-11-21Bibliographically approved
Olsson, E., Karlström, B., Kilander, L., Byberg, L., Cederholm, T. & Sjögren, P. (2015). Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men. Journal of Alzheimer's Disease, 43(1), 109-119
Open this publication in new window or tab >>Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men
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2015 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 43, no 1, p. 109-119Article in journal (Refereed) Published
Abstract [en]

Background:

Adherence to dietary patterns has been associated with cognitive decline and dementia, but studies are inconsistent.

Objective:

Dietary patterns, i.e., WHO recommendations (Healthy Diet Indicator), a Mediterranean-like diet (modified Mediterranean Diet Score, mMDS), and a low carbohydrate high protein diet (LCHP), were related to incident cognitive dysfunction, as indicated by Alzheimer's disease (AD), all-type dementia, and all-type cognitive impairment, in a cohort of 1,138 elderly Swedish men.

Methods:

Dietary patterns were derived from 7-day records. Risk relations were calculated by Cox and logistic regression analyses, adjusted for potential confounders. Sensitivity analysis was performed in a subpopulation (n = 564) with energy intake according to the Goldberg cut-off.

Results:

During a mean follow-up of 12 years, 84, 143, and 198 men developed AD, all-type dementia, and all-type cognitive impairment, respectively. There was no association between Healthy Diet Indicator and any of the outcomes. Hazard ratios associated with 1 standard deviation (SD) increment in the LCHP score were 1.16 (95% confidence interval [CI]: 0.95, 1.43) for AD and 1.16 (95% CI: 0.99, 1.37) for all-type dementia. mMDS was not associated with dementia diagnosis. Odds ratio (OR)/1 SD increase for mMDS and all-type cognitive impairment was 0.82 (95% CI: 0.65, 1.05). In the subpopulation OR for mMDS and all-type cognitive impairment was 0.32 (95% CI: 0.11, 0.89).

Conclusion:

We found no strong associations with development of cognitive dysfunction for any of the dietary patterns investigated. However, there was a potentially beneficial association for a Mediterranean-like diet on the development of cognitive dysfunction in the subpopulation.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-233262 (URN)10.3233/JAD-140867 (DOI)000344525900011 ()25062901 (PubMedID)
Available from: 2014-10-01 Created: 2014-10-01 Last updated: 2018-08-24Bibliographically approved
Lövestam, E., Orrevall, Y., Koochek, A., Karlström, B. & Andersson, A. (2015). Evaluation of Nutrition Care Process documentation in electronic patient records: Need of improvement. Nutrition & Dietetics, 72(1), 74-80
Open this publication in new window or tab >>Evaluation of Nutrition Care Process documentation in electronic patient records: Need of improvement
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2015 (English)In: Nutrition & Dietetics, ISSN 1446-6368, E-ISSN 1747-0080, Vol. 72, no 1, p. 74-80Article in journal (Refereed) Published
Abstract [en]

Aim

High-quality documentation in patient records is essential for patient safety and plays a prominent role in the delivery and evaluation of dietetic/nutrition care. We aimed to evaluate dietitians' documentation in patient records according to the four steps in the Nutrition Care Process: assessment, diagnosis, intervention and monitoring/evaluation.

Methods

A retrospective audit of 147 systematically collected outpatient dietetic notes from primary care centres and hospitals in central Sweden was performed using a validated audit instrument. The instrument was used to assess the documentation of 14 items: 10 items focusing on the Nutrition Care Process steps and four items on language clarity and structure, with a maximum total score of 26 for each dietetic note. The notes were divided into three different quality levels, A (high score), B (medium score) or C (low score). Comparisons were made between notes from primary care and hospitals.

Results

The audit showed that the majority of the notes were placed at level B, scoring 13.5–19.5. Only 3% of the notes scored higher than 19.5. The most frequently documented items were intervention (90%), evaluation (70%) and nutrition problem (56%), whereas the least documented items were nutrition prescription (15%), goal of intervention (9%) and connection of problem-etiology-symptom (5%). Flaws in lingual clarity were common (72%). Primary care notes received higher scores than those from hospitals.

Conclusions

The audit shows that Swedish dietetic documentation needs to be improved, for example, by further training and education in the Nutrition Care Process and its standardised terminology.

National Category
Other Social Sciences Nutrition and Dietetics
Research subject
Food, Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-230205 (URN)10.1111/1747-0080.12128 (DOI)000352153400012 ()
Available from: 2014-08-20 Created: 2014-08-20 Last updated: 2017-12-05Bibliographically approved
Lövestam, E., Orrevall, Y., Koochek, A., Karlström, B. & Andersson, A. (2014). Evaluation of a Nutrition Care Process-based audit instrument, the Diet-NCP-Audit, for documentation of dietetic care in medical records. Scandinavian Journal of Caring Sciences, 28(2), 390-397
Open this publication in new window or tab >>Evaluation of a Nutrition Care Process-based audit instrument, the Diet-NCP-Audit, for documentation of dietetic care in medical records
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2014 (English)In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 28, no 2, p. 390-397Article in journal (Refereed) Published
Abstract [en]

Adequate documentation in medical records is important for high-quality health care. Documentation quality is widely studied within nursing, but studies are lacking within dietetic care. The aim of this study was to translate, elaborate and evaluate an audit instrument, based on the four-step Nutrition Care Process model, for documentation of dietetic care in medical records. The audit instrument includes 14 items focused on essential parts of dietetic care and the documentation's clarity and structure. Each item is to be rated 0-1 or 0-2 points, with a maximum total instrument score of 26. A detailed manual was added to facilitate the interpretation and increase the reliability of the instrument. The instrument is based on a similar tool initiated 9 years ago in the United States, which in this study was translated to Swedish and further elaborated. The translated and further elaborated instrument was named Diet-NCP-Audit. Firstly, the content validity of the Diet-NCP-Audit instrument was tested by five experienced dietitians. They rated the relevance and clarity of the included items. After a first rating, minor improvements were made. After the second rating, the Content Validity Indexes were 1.0, and the Clarity Index was 0.98. Secondly, to test the reliability, four dietitians reviewed 20 systematically collected dietetic notes independently using the audit instrument. Before the review, a calibration process was performed. A comparison of the reviews was performed, which resulted in a moderate inter-rater agreement with Krippendorff's α = 0.65-0.67. Grouping the audit results in three levels: lower, medium or higher range, a Krippendorff's α of 0.74 was considered high reliability. Also, an intra-rater reliability test-retest with a 9 weeks interval, performed by one dietitian, showed strong agreement. To conclude, the evaluated audit instrument had high content validity and moderate to high reliability and can be used in auditing documentation of dietetic care.

Keywords
Dietetic, documentation, medical records, nutrition care process
National Category
Social Sciences Interdisciplinary Health Care Service and Management, Health Policy and Services and Health Economy
Research subject
Food, Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-200517 (URN)10.1111/scs.12049 (DOI)000334503400021 ()
Available from: 2013-05-29 Created: 2013-05-29 Last updated: 2018-01-11Bibliographically approved
Delgado-Lista, J., Perez-Martinez, P., Garcia-Rios, A., Phillips, C. M., Hall, W., Gjelstad, I. M., . . . Lopez-Miranda, J. (2013). A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome. NMCD. Nutrition Metabolism and Cardiovascular Diseases, 23(5), 417-423
Open this publication in new window or tab >>A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome
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2013 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 23, no 5, p. 417-423Article in journal (Refereed) Published
Abstract [en]

Background and aims: CCAAT/enhancer-binding protein alpha (CEBPA) is a transcription factor involved in adipogenesis and energy homeostasis. Caloric restriction reduces CEBPA protein expression in patients with metabolic syndrome (MetS). A previous report linked rs12691 SNP in CEBPA to altered concentration of fasting triglycerides. Our objective was to assess the effects of rs12691 in glucose metabolism in Metabolic Syndrome (MetS) patients. Methods and results: Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. Carriers of the minor A allele of rs12691 had altered disposition index (p = 0.0003), lower acute insulin response (p = 0.005) and a lower insulin sensitivity index (p = 0.025) indicating a lower insulin sensitivity and a lower insulin secretion, at baseline and at the end of the diets. Furthermore, A allele carriers displayed lower HDL concentration. Conclusion: The presence of the A allele of rs12691 influences glucose metabolism of MetS patients. Clinical Trials Registry number NCT00429195.

Keywords
Metabolic syndrome, CEBP alpha, C/EBP alpha, insulin secretion, insulin resistance
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-203359 (URN)10.1016/j.numecd.2011.09.008 (DOI)000319337600008 ()
Note

De två första författarna delar förstaförfattarskapet.

De två sista författarna delar sistaförfattarskapet.

Available from: 2013-07-10 Created: 2013-07-09 Last updated: 2017-12-06Bibliographically approved
Olsson, E., Karlström, B., Kilander, L., Byberg, L., Cederholm, T. & Sjögren, P. (2013). Dietary Patterns And Cognitive Dysfunction In A Prospective Study Of 70-Year-Old Swedish Men. Paper presented at 20th International Congress of Nutrition; 15-20 September 2013; Granada, Spain. Annals of Nutrition and Metabolism, 63(Suppl. 1), 862-862
Open this publication in new window or tab >>Dietary Patterns And Cognitive Dysfunction In A Prospective Study Of 70-Year-Old Swedish Men
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2013 (English)In: Annals of Nutrition and Metabolism, ISSN 0250-6807, E-ISSN 1421-9697, Vol. 63, no Suppl. 1, p. 862-862Article in journal, Meeting abstract (Other academic) Published
Keywords
Dietary pattern, dementia, alzheimers disease, Epidemiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-211619 (URN)000324548203125 ()
Conference
20th International Congress of Nutrition; 15-20 September 2013; Granada, Spain
Available from: 2013-11-28 Created: 2013-11-27 Last updated: 2018-08-24
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