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Pochard, I., Vall, M., Eriksson, J., Farineau, C., Cheung, O., Frykstrand, S., . . . Strömme, M. (2018). Amine-functionalised mesoporous magnesium carbonate: Dielectric spectroscopy studies of interactions with water and stability. Materials Chemistry and Physics, 216, 332-338
Open this publication in new window or tab >>Amine-functionalised mesoporous magnesium carbonate: Dielectric spectroscopy studies of interactions with water and stability
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2018 (English)In: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 216, p. 332-338Article in journal (Refereed) Published
Abstract [en]

A mesoporous magnesium carbonate (MMC) material that was first described in 2013 is currently being investigated for several industrial and life-science-based applications. In this paper, the effect of functionalising the surface of MMC with amine groups on the water interaction properties of the material is investigated in detail. Amine functionalisation enhanced the stability and water sorption-release properties of the material. This is explained by the low affinity between amine-functionalised MMC and water molecules, as attested by the high free/total water ratio shown by dielectric spectroscopy. This low affinity had an impact on the total amount of adsorbed water at low relative humidities (RHs) but not at high RHs. The functionalisation of MMC with amine groups also stabilised the material in moist environments, hindering spontaneous crystallisation. These results provide a more fundamental understanding of the water interaction properties of MMC and are also expected to facilitate optimisation of the stability of materials like this for novel drug formulations and other life-science applications, as well as for their use in humidity control.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2018
Keywords
Magnesium carbonate, Mesoporous, Amine functionalisation, Moisture, Dielectric spectroscopy
National Category
Materials Chemistry Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-362476 (URN)10.1016/j.matchemphys.2018.05.053 (DOI)000441492000044 ()
Funder
Swedish Research Council, 2014-3929
Available from: 2018-10-05 Created: 2018-10-05 Last updated: 2018-10-09Bibliographically approved
Sun, R., Zhang, P., Bajnóczi, É. G., Neagu, A., Tai, C.-W., Persson, I., . . . Cheung, O. (2018). Amorphous Calcium Carbonate Constructed from Nanoparticle Aggregates with Unprecedented Surface Area and Mesoporosity. ACS Applied Materials and Interfaces, 10(25), 21556-21564
Open this publication in new window or tab >>Amorphous Calcium Carbonate Constructed from Nanoparticle Aggregates with Unprecedented Surface Area and Mesoporosity
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2018 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 10, no 25, p. 21556-21564Article in journal (Refereed) Published
Abstract [en]

Amorphous calcium carbonate (ACC), with the highest reported specific surface area of all current forms of calcium carbonate (over 350 m2 g-1), was synthesized using a surfactant-free, one-pot method. Electron microscopy, helium pycnometry, and nitrogen sorption analysis revealed that this highly mesoporous ACC, with a pore volume of ∼0.86 cm3 g-1 and a pore-size distribution centered at 8-9 nm, is constructed from aggregated ACC nanoparticles with an estimated average diameter of 7.3 nm. The porous ACC remained amorphous and retained its high porosity for over 3 weeks under semi-air-tight storage conditions. Powder X-ray diffraction, large-angle X-ray scattering, infrared spectroscopy, and electron diffraction exposed that the porous ACC did not resemble any of the known CaCO3 structures. The atomic order of porous ACC diminished at interatomic distances over 8 Å. Porous ACC was evaluated as a potential drug carrier of poorly soluble substances in vitro. Itraconazole and celecoxib remained stable in their amorphous forms within the pores of the material. Drug release rates were significantly enhanced for both drugs (up to 65 times the dissolution rates for the crystalline forms), and supersaturation release of celecoxib was also demonstrated. Citric acid was used to enhance the stability of the ACC nanoparticles within the aggregates, which increased the surface area of the material to over 600 m2 g-1. This porous ACC has potential for use in various applications where surface area is important, including adsorption, catalysis, medication, and bone regeneration.

Keywords
amorphous calcium carbonate, drug delivery, large-angle X-ray scattering, nanoparticles, porous materials
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-358032 (URN)10.1021/acsami.8b03939 (DOI)000437811400059 ()29862822 (PubMedID)
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2014-3929
Available from: 2018-08-23 Created: 2018-08-23 Last updated: 2018-09-21Bibliographically approved
Yang, J., Alvebratt, C., Lu, X., Bergström, C., Strömme, M. & Welch, K. (2018). Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen. International Journal of Pharmaceutics, 548(1), 515-521
Open this publication in new window or tab >>Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen
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2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 548, no 1, p. 515-521Article in journal (Refereed) Published
Abstract [en]

Formulating active pharmaceutical ingredients (APIs) in the amorphous state can increase their apparent aqueous solubility and dissolution rate and consequently improve their bioavailability. This study demonstrates, for the first time, the ability to stabilize an API in the amorphous state using a solid dispersion of magnesium carbonate nanoparticles within the API. Specifically, high proportions of ibuprofen were able to be stabilized in the amorphous state using as little as 17% wt/wt amorphous magnesium carbonate nanoparticles, and drug release rates 83 times faster than from the crystalline state were achieved. Biocompatibility of the nanoparticles was demonstrated in vitro using human dermal fibroblasts and stability of the nanocomposite formulation was verified with a storage time of six months. The success of this novel formulation provides a promising approach for achieving improved apparent solubility and enhanced bioavailability of drugs.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Magnesium carbonate, Nanoparticles, Nanocomposite, Amorphous, Ibuprofen, Solubility, Dissolution
National Category
Nano Technology Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-354506 (URN)10.1016/j.ijpharm.2018.07.021 (DOI)000440552100050 ()29981897 (PubMedID)
Funder
Swedish Research Council
Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-11-12Bibliographically approved
Strömme, M. (2018). Be ready for new opportunities! Nanotechnology will change our way of living. In: The Swedsih Lunch 2018: . Paper presented at World Economic Forum. Davos 22-24/1 2018. The Swedish Lunch 2018..
Open this publication in new window or tab >>Be ready for new opportunities! Nanotechnology will change our way of living
2018 (English)In: The Swedsih Lunch 2018, 2018Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-339080 (URN)
Conference
World Economic Forum. Davos 22-24/1 2018. The Swedish Lunch 2018.
Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-02-15Bibliographically approved
Rocha, I., Lindh, J., Hong, J., Strömme, M., Mihranyan, A. & Ferraz, N. (2018). Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads. Molecules, 23(3), Article ID 601.
Open this publication in new window or tab >>Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads
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2018 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, no 3, article id 601Article in journal (Refereed) Published
Abstract [en]

Sulfonated cellulose beads were prepared by oxidation of Cladophora nanocellulose to 2,3-dialdehyde cellulose followed by sulfonation using bisulfite. The physicochemical properties of the sulfonated beads, i.e., high surface area, high degree of oxidation, spherical shape, and the possibility of tailoring the porosity, make them interesting candidates for the development of immunosorbent platforms, including their application in extracorporeal blood treatments. A desired property for materials used in such applications is blood compatibility; therefore in the present work, we investigate the hemocompatibility of the sulfonated cellulose beads using an in vitro whole blood model. Complement system activation (C3a and sC5b-9 levels), coagulation activation (thrombin-antithrombin (TAT) levels) and hemolysis were evaluated after whole blood contact with the sulfonated beads and the results were compared with the values obtained with the unmodified Cladophora nanocellulose. Results showed that neither of the cellulosic materials presented hemolytic activity. A marked decrease in TAT levels was observed after blood contact with the sulfonated beads, compared with Cladophora nanocellulose. However, the chemical modification did not promote an improvement in Cladophora nanocellulose hemocompatibility in terms of complement system activation. Even though the sulfonated beads presented a significant reduction in pro-coagulant activity compared with the unmodified material, further modification strategies need to be investigated to control the complement activation by the cellulosic materials.

Keywords
sulfonated beads; Cladophora nanocellulose; hemocompatibility; coagulation; complement system
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-346209 (URN)10.3390/molecules23030601 (DOI)
Funder
Knut and Alice Wallenberg Foundation
Available from: 2018-03-15 Created: 2018-03-15 Last updated: 2018-07-27Bibliographically approved
Vall, M., Hultberg, J., Strömme, M. & Cheung, O. (2018). Carbon dioxide adsorption on mesoporous magnesiumcarbonate. In: 10th International Conference on Applied Energy (ICAE2018): . Paper presented at 10th International Conference on Applied Energy (ICAE2018), 22-25 August 2018, Hong Kong, China. Hong Kong
Open this publication in new window or tab >>Carbon dioxide adsorption on mesoporous magnesiumcarbonate
2018 (English)In: 10th International Conference on Applied Energy (ICAE2018), Hong Kong, 2018Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Hong Kong: , 2018
National Category
Other Materials Engineering
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-353385 (URN)
Conference
10th International Conference on Applied Energy (ICAE2018), 22-25 August 2018, Hong Kong, China
Available from: 2018-06-12 Created: 2018-06-12 Last updated: 2018-10-24Bibliographically approved
Ruan, C., Wang, Z., Lindh, J. & Strömme, M. (2018). Carbonized cellulose beads for efficient capacitive energy storage. Cellulose (London), 25(6), 3545-3556
Open this publication in new window or tab >>Carbonized cellulose beads for efficient capacitive energy storage
2018 (English)In: Cellulose (London), ISSN 0969-0239, E-ISSN 1572-882X, Vol. 25, no 6, p. 3545-3556Article in journal (Refereed) Published
Abstract [en]

Natural biomaterials, including polysaccharides and amino acids, provide a sustainable source of functional carbon materials for electric energy storage applications. We present a one-pot reductive amination process to functionalize 2,3-dialdehyde cellulose (DAC) beads with chitosan and l-cysteine to provide single (N)- and dual (N/S)-doped materials. The functionalization enables the physicochemical properties of the materials to be tailored and can provide carbon precursors with heteroatom doping suitable for energy storage applications. Scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis were used to characterize the changes to the beads after functionalization and carbonization. The results of X-ray photoelectron spectroscopy and energy-dispersive X-ray spectroscopy verified that the doping was effective, while the nitrogen sorption isotherms and pore-size distributions of the carbonized beads showed the effects of doping with different hierarchical porosities. In the electrochemical experiments, three kinds of carbon beads [pyrolyzed from DAC, chitosan-crosslinked DAC (CS-DAC) and l-cysteine-functionalized DAC] were used as electrode materials. Electrodes of carbonized CS-DAC beads had a specific capacitance of up to 242 F g(-1) at a current density of 1 A g(-1). These electrodes maintained a capacitance retention of 91.5% after 1000 charge/discharge cycles, suggesting excellent cycling stability. The results indicate that reductive amination of DAC is an effective route for heteroatom doping of carbon materials to be used as electrode active materials for energy storage.

Keywords
2, 3-Dialdehyde cellulose (DAC) beads, Nitrogen doping, Nitrogen/sulfur doping, Supercapacitor
National Category
Materials Chemistry Physical Chemistry Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-357553 (URN)10.1007/s10570-018-1811-6 (DOI)000432990300030 ()
Funder
Swedish Foundation for Strategic Research Stiftelsen Olle Engkvist Byggmästare
Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2018-08-17Bibliographically approved
Strietzel, C., Emanuelsson, R., Strömme, M. & Sjödin, M. (2018). Conducting Redox Polymer Batteries. In: : . Paper presented at Electronic Processes in Organic Materials (GRC).
Open this publication in new window or tab >>Conducting Redox Polymer Batteries
2018 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-364962 (URN)
Conference
Electronic Processes in Organic Materials (GRC)
Funder
SweGRIDS - Swedish Centre for Smart Grids and Energy Storage
Available from: 2018-11-07 Created: 2018-11-07 Last updated: 2018-11-07
Sjödin, M., Emanuelsson, R., Sterby, M., Huang, H., Wang, H. & Strömme, M. (2018). Conducting Redox Polymer Batteries. In: : . Paper presented at Americas International Meeting on Electrochemistry and Solid State Science 2018.
Open this publication in new window or tab >>Conducting Redox Polymer Batteries
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2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-365693 (URN)
Conference
Americas International Meeting on Electrochemistry and Solid State Science 2018
Available from: 2018-11-12 Created: 2018-11-12 Last updated: 2018-11-16
Strömme, M. (2018). Den stora ändringen i det lilla. Nanotenologin ändrar industrin. In: DnB (Ed.), Industrikonferansen 2018: Risk and Reward. Paper presented at Industrikonferansen 2018; Risk and Reward. Oslo Norway 16/1 2018..
Open this publication in new window or tab >>Den stora ändringen i det lilla. Nanotenologin ändrar industrin
2018 (Swedish)In: Industrikonferansen 2018: Risk and Reward / [ed] DnB, 2018Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-339079 (URN)
Conference
Industrikonferansen 2018; Risk and Reward. Oslo Norway 16/1 2018.
Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-02-15Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-5496-9664

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