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Publications (10 of 565) Show all publications
Strömme, M. (2018). Be ready for new opportunities! Nanotechnology will change our way of living. In: The Swedsih Lunch 2018: . Paper presented at World Economic Forum. Davos 22-24/1 2018. The Swedish Lunch 2018..
Open this publication in new window or tab >>Be ready for new opportunities! Nanotechnology will change our way of living
2018 (English)In: The Swedsih Lunch 2018, 2018Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-339080 (URN)
Conference
World Economic Forum. Davos 22-24/1 2018. The Swedish Lunch 2018.
Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-02-15Bibliographically approved
Rocha, I., Lindh, J., Hong, J., Strömme, M., Mihranyan, A. & Ferraz, N. (2018). Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads. Molecules, 23(3), 601-612
Open this publication in new window or tab >>Blood Compatibility of Sulfonated Cladophora Nanocellulose Beads
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2018 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, no 3, p. 601-612Article in journal (Refereed) Published
Abstract [en]

Sulfonated cellulose beads were prepared by oxidation of Cladophora nanocellulose to 2,3-dialdehyde cellulose followed by sulfonation using bisulfite. The physicochemical properties of the sulfonated beads, i.e., high surface area, high degree of oxidation, spherical shape, and the possibility of tailoring the porosity, make them interesting candidates for the development of immunosorbent platforms, including their application in extracorporeal blood treatments. A desired property for materials used in such applications is blood compatibility; therefore in the present work, we investigate the hemocompatibility of the sulfonated cellulose beads using an in vitro whole blood model. Complement system activation (C3a and sC5b-9 levels), coagulation activation (thrombin-antithrombin (TAT) levels) and hemolysis were evaluated after whole blood contact with the sulfonated beads and the results were compared with the values obtained with the unmodified Cladophora nanocellulose. Results showed that neither of the cellulosic materials presented hemolytic activity. A marked decrease in TAT levels was observed after blood contact with the sulfonated beads, compared with Cladophora nanocellulose. However, the chemical modification did not promote an improvement in Cladophora nanocellulose hemocompatibility in terms of complement system activation. Even though the sulfonated beads presented a significant reduction in pro-coagulant activity compared with the unmodified material, further modification strategies need to be investigated to control the complement activation by the cellulosic materials.

Keyword
sulfonated beads; Cladophora nanocellulose; hemocompatibility; coagulation; complement system
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-346209 (URN)10.3390/molecules23030601 (DOI)
Available from: 2018-03-15 Created: 2018-03-15 Last updated: 2018-03-16Bibliographically approved
Strömme, M. (2018). Den stora ändringen i det lilla. Nanotenologin ändrar industrin. In: DnB (Ed.), Industrikonferansen 2018: Risk and Reward. Paper presented at Industrikonferansen 2018; Risk and Reward. Oslo Norway 16/1 2018..
Open this publication in new window or tab >>Den stora ändringen i det lilla. Nanotenologin ändrar industrin
2018 (Swedish)In: Industrikonferansen 2018: Risk and Reward / [ed] DnB, 2018Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-339079 (URN)
Conference
Industrikonferansen 2018; Risk and Reward. Oslo Norway 16/1 2018.
Available from: 2018-01-15 Created: 2018-01-15 Last updated: 2018-02-15Bibliographically approved
Xu, C., Ruan, C.-Q., Li, Y., Lindh, J. & Strömme, M. (2018). High-performance activated carbons synthesized from nanocellulose for CO2 capture and extremely selective removal of volatile organic compounds. Advanced Sustainable Systems, 2(2), Article ID 1700147.
Open this publication in new window or tab >>High-performance activated carbons synthesized from nanocellulose for CO2 capture and extremely selective removal of volatile organic compounds
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2018 (English)In: Advanced Sustainable Systems, E-ISSN 2366-7486, Vol. 2, no 2, article id 1700147Article in journal (Refereed) Published
Abstract [en]

A series of sustainable activated carbons (ACs) with large surface areas and tunable pore sizes is synthesized from Cladophora cellulose and its chemically modified derivatives in a one-step physical carbonization/activation process. The molecular structure of the cellulose precursors and the carbonization/activation atmosphere (N2 or CO2) significantly influence the pore structure of the ACs. When using oxidized cellulose and its further cross-linkages as the precursor, the ACs have a large volume of ultramicropores (pore diameter < 0.8 nm). Activation in CO2 results in ACs with surface areas up to 1241 m2 g−1. These ACs have a high CO2 uptake capacity (2.29 mmol g−1 at 0.15 bar, 5.52 mmol g−1 at 1 bar; 273 K) and a high CO2–over–N2 selectivity (42 at 273 K). In addition, the capacity of the ACs to adsorb vapors of volatile organic compounds (VOCs) is remarkable, with values up to 0.97 mmol g−1 at very low VOC concentrations (200 ppmv). The ACs have ultrahigh VOCs–over–N2 selectivity up to 9.35 × 103 at 293 K for 0.02 vol%/99.8 vol% of benzene/N2 mixture. It is anticipated that these ACs will be useful as sorbents for the postcombustion capture of CO2 and for indoor removal and direct air capture of various VOCs.

National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-333723 (URN)10.1002/adsu.201700147 (DOI)000424712800009 ()
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2018-03-28Bibliographically approved
Basu, A., Heitz, K., Strömme, M., Welch, K. & Ferraz, N. (2018). Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications. Carbohydrate Polymers, 181, 345-350
Open this publication in new window or tab >>Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications
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2018 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, p. 345-350Article in journal (Refereed) Published
Abstract [en]

Development of advanced dressings with antimicrobial properties for the treatment of infected wounds is an important approach in the fight against evolution of antibiotic resistant bacterial strains. Herein, the effects of ion-crosslinked nanocellulose hydrogels on bacteria commonly found in infected wounds were investigated in vitro. By using divalent calcium or copper ions as crosslinking agents, different antibacterial properties against the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa were obtained. Calcium crosslinked hydrogels were found to retard S. epidermidis growth (up to 266% increase in lag time, 36% increase in doubling time) and inhibited P. aeruginosa biofilm formation, while copper crosslinked hydrogels prevented S. epidermidis growth and were bacteriostatic towards P. aeruginosa (49% increase in lag time, 78% increase in doubling time). The wound dressing candidates furthermore displayed barrier properties towards both S. epidermidis and P. aeruginosa, hence making them interesting for further development of advanced wound dressings with tunable antibacterial properties.

Keyword
Nanofibrillated cellulose, Biofilm, Wound dressing, Infected wound
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-333382 (URN)10.1016/j.carbpol.2017.10.085 (DOI)000418661000041 ()29253982 (PubMedID)
Funder
Swedish Research Council Formas
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2018-02-27Bibliographically approved
Pan, R., Xu, X., Sun, R., Wang, Z., Lindh, J., Edström, K., . . . Nyholm, L. (2018). Nanocellulose Modified Polyethylene Separators for Lithium Metal Batteries. Small, 1-9, Article ID 1704371.
Open this publication in new window or tab >>Nanocellulose Modified Polyethylene Separators for Lithium Metal Batteries
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2018 (English)In: Small, p. 1-9, article id 1704371Article in journal (Refereed) Published
Abstract [en]

Abstract Poor cycling stability and safety concerns regarding lithium (Li) metal anodes are two major issues preventing the commercialization of high‐energy density Li metal‐based batteries. Herein, a novel tri‐layer separator design that significantly enhances the cycling stability and safety of Li metal‐based batteries is presented. A thin, thermally stable, flexible, and hydrophilic cellulose nanofiber layer, produced using a straightforward paper‐making process, is directly laminated on each side of a plasma‐treated polyethylene (PE) separator. The 2.5 µm thick, mesoporous (≈20 nm average pore size) cellulose nanofiber layer stabilizes the Li metal anodes by generating a uniform Li+ flux toward the electrode through its homogenous nanochannels, leading to improved cycling stability. As the tri‐layer separator maintains its dimensional stability even at 200 °C when the internal PE layer is melted and blocks the ion transport through the separator, the separator also provides an effective thermal shutdown function. The present nanocellulose‐based tri‐layer separator design thus significantly facilitates the realization of high‐energy density Li metal‐based batteries.

Keyword
cellulose, current distribution, lithium dendrites, lithium metal batteries, separators
National Category
Materials Chemistry Engineering and Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-349143 (URN)10.1002/smll.201704371 (DOI)
Available from: 2018-04-22 Created: 2018-04-22 Last updated: 2018-05-02Bibliographically approved
Strömme, M. (2018). Nanoteknologini framtida vård. : Möjligheter och hinder. In: Ramboll (Ed.), Rambolls sjukhuskonferens 2018:: Vårdmiljöer rustade för tekniksprång. Paper presented at Rambolls sjukhuskonferens 2018: Vårdmiljöer rustade för tekniksprång. Kulturhuset, Stockholm 6/2 2018.. Stockholm
Open this publication in new window or tab >>Nanoteknologini framtida vård. : Möjligheter och hinder
2018 (Swedish)In: Rambolls sjukhuskonferens 2018:: Vårdmiljöer rustade för tekniksprång / [ed] Ramboll, Stockholm, 2018Conference paper, Oral presentation with published abstract (Other academic)
Place, publisher, year, edition, pages
Stockholm: , 2018
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-341006 (URN)
Conference
Rambolls sjukhuskonferens 2018: Vårdmiljöer rustade för tekniksprång. Kulturhuset, Stockholm 6/2 2018.
Available from: 2018-02-05 Created: 2018-02-05 Last updated: 2018-02-05
Ruan, C., Strömme, M. & Lindh, J. (2018). Preparation of Porous 2,3-dialdehyde Cellulose Beads Crosslinked with Chitosan and their Application in Adsorption of Congo Red Dye. Carbohydrate Polymers, 181, 200-207
Open this publication in new window or tab >>Preparation of Porous 2,3-dialdehyde Cellulose Beads Crosslinked with Chitosan and their Application in Adsorption of Congo Red Dye
2018 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, p. 200-207Article in journal (Refereed) Published
Abstract [en]

Micrometer sized 2,3-dialdehyde cellulose (DAC) beads were produced via a recently developed method relying on periodate oxidation of Cladophora nanocellulose. The produced dialdehyde groups and pristine hydroxyl groups provided the DAC beads with a vast potential for further functionalization. The sensitivity of the DAC beads to alkaline conditions, however, limits their possible functionalization and applications. Hence, alkaline-stable and porous cellulose beads were prepared via a reductive amination crosslinking reaction between 2,3-dialdehyde cellulose beads and chitosan. The produced materials were thoroughly characterized with different methods. The reaction conditions, including the amount of chitosan used, conditions for reductive amination, reaction temperature and time, were investigated and the maintained morphology of the beads after exposure to 1 M NaOH (aq.) was verified with SEM. Different washing and drying procedures were used and the results were studied by SEM and BET analysis. Furthermore, FTIR, TGA, EDX, XPS, DLS and elemental analysis were performed to characterize the properties of the prepared beads. Finally, the alkaline-stable porous chitosan cross-linked 2,3-dialdehyde cellulose beads were applied as adsorbent for the dye Congo red. The crosslinked beads displayed fast and high adsorption capacity at pH 2 and good desorption properties at pH 12, providing a promising sorption material.

Keyword
Cladophora nanocellulose, 2, 3-Dialdehyde cellulose beads Chitosan, Crosslink, Congo red dye
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-334956 (URN)10.1016/j.carbpol.2017.10.072 (DOI)000418661000025 ()29253964 (PubMedID)
Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2018-01-25Bibliographically approved
Rocha, I., Ferraz, N., Mihranyan, A., Strömme, M. & Lindh, J. (2018). Sulfonated Nanocellulose Beads as Potential Immunosorbents. Cellulose (London), 28(3), 1899-1910
Open this publication in new window or tab >>Sulfonated Nanocellulose Beads as Potential Immunosorbents
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2018 (English)In: Cellulose (London), ISSN 0969-0239, E-ISSN 1572-882X, Vol. 28, no 3, p. 1899-1910Article in journal (Refereed) Published
Abstract [en]

Herein 2,3-dialdehyde cellulose beads prepared from Cladophora green algae nanocellulose were sulfonated and characterized by FTIR, conductometric titration, elemental analysis, SEM, ζ-potential, nitrogen adsorption–desorption and laser diffraction, aiming for its application as a potential immunosorbent material. Porous beads were prepared at mild reaction conditions in water and were chemically modified by sulfonation and reduction. The obtained 15 µm sized sulfonated beads were found to be highly charged and to have a high surface area of ~ 100 m2 g−1 and pore sizes between 20 and 60 nm, adequate for usage as immunosorbents. After reduction of remaining aldehyde groups, the beads could be classified as non-cytotoxic in indirect toxicity studies with human dermal fibroblasts as a first screening of their biocompatibility. The observed properties make the sulfonated cellulose beads interesting for further development as matrix material in immunosorbent devices.

Keyword
Periodate oxidation Dialdehyde cellulose, Surface group density, Sulfonated beads, Cytotoxicity
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-346207 (URN)10.1007/s10570-018-1661-2 (DOI)000427379200027 ()
Funder
Knut and Alice Wallenberg Foundation
Available from: 2018-03-15 Created: 2018-03-15 Last updated: 2018-05-18Bibliographically approved
Sepehri, S., Eriksson, E., Kalaboukhov, A., Zardán Gómez de la Torre, T., Kustanovich, K., Jesorka, A., . . . Winkler, D. (2018). Volume-amplified magnetic bioassay integrated with microfluidic sample handling and high-Tc SQUID magnetic readout. APL Bioengineering, 2(1), Article ID 016102.
Open this publication in new window or tab >>Volume-amplified magnetic bioassay integrated with microfluidic sample handling and high-Tc SQUID magnetic readout
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2018 (English)In: APL Bioengineering, Vol. 2, no 1, article id 016102Article in journal (Refereed) Published
Abstract [en]

A bioassay based on a high-Tc superconducting quantum interference device (SQUID) reading out functionalized magnetic nanoparticles (fMNPs) in a prototype microfluidic platform is presented. The target molecule recognition is based on volume amplification using padlock-probe-ligation followed by rolling circle amplification (RCA). The MNPs are functionalized with single-stranded oligonucleotides, which give a specific binding of the MNPs to the large RCA coil product, resulting in a large change in the amplitude of the imaginary part of the ac magnetic susceptibility. The RCA products from amplification of synthetic Vibrio cholera target DNA were investigated using our SQUID ac susceptibility system in microfluidic channel with an equivalent sample volume of 3 μl. From extrapolation of the linear dependence of the SQUID signal versus concentration of the RCA coils, it is found that the projected limit of detection for our system is about 1.0 × 105 RCA coils (0.2 × 10−18 mol), which is equivalent to 66 fM in the 3 μl sample volume. This ultra-high magnetic sensitivity and integration with microfluidic sample handling are critical steps towards magnetic bioassays for rapid detection of DNA and RNA targets at the point of care.

Place, publisher, year, edition, pages
American Institute of Physics, 2018
National Category
Other Materials Engineering
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-349146 (URN)10.1063/1.4999713 (DOI)
Available from: 2018-04-22 Created: 2018-04-22 Last updated: 2018-05-03Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-5496-9664

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