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Dong, C., Liu, J., Quaranta, A., Jing, X., Nie, M., Wheelock, C. E., . . . Adner, M. (2024). Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid. Frontiers in Pharmacology, 15, Article ID 1503648.
Open this publication in new window or tab >>Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid
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2024 (English)In: Frontiers in Pharmacology, E-ISSN 1663-9812, Vol. 15, article id 1503648Article in journal (Refereed) Published
Abstract [en]

Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS. Polyvinylalcohol-carbazate (PVAC), a polymer that can bind endogenous aldehydes, neutralize oxidative stress and inhibit inflammatory factors, may be a potential treatment for ALI/ARDS.Methods A hydrochloric acid (HCl) induced mouse model was employed to assess the effect of PVAC. The changes of lung mechanics, pulmonary edema, histology and immune cells, cytokines, and lipid mediators in bronchioalveolar lavage fluid (BALF) were investigated in HCl-challenged mice.Results In the HCl model, PVAC administration alleviated airway hyperresponsiveness and improved pulmonary edema and damage. In addition, it decreased the recruitment of neutrophils to the lung, and inhibited the increase of IL-6, TNF-alpha and leukotriene B4.Conclusion These data indicates that PVAC is a potential candidate for the treatment of ALI/ARDS induced by aspiration of gastric acid or for the control of "asthma-like" symptoms in patients with gastroesophageal reflux.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
acute respiratory distress syndrome, aspiration pneumonia, oxidative stress, pharmacological treatment, intranasal administration
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-545458 (URN)10.3389/fphar.2024.1503648 (DOI)001370096600001 ()39650159 (PubMedID)
Funder
Swedish Heart Lung Foundation, 20180514Swedish Heart Lung Foundation, 20210297Swedish Research Council, 2019-01630
Available from: 2025-01-08 Created: 2025-01-08 Last updated: 2025-01-08Bibliographically approved
Majumdar Svensson, O. & Melander Bowden, T. (2024). Poly(β‐amino ester) based solid polymer electrolytes for lithium‐ion batteries. Journal of Applied Polymer Science, 141(15), Article ID e55220.
Open this publication in new window or tab >>Poly(β‐amino ester) based solid polymer electrolytes for lithium‐ion batteries
2024 (English)In: Journal of Applied Polymer Science, ISSN 0021-8995, E-ISSN 1097-4628, Vol. 141, no 15, article id e55220Article in journal (Refereed) Published
Abstract [en]

In this paper, we present the synthesis of poly(β-amino ester)-based solid polymer electrolytes (SPE) from off-stoichiometric acrylate-amine formulations using one-step, catalyst and solvent free aza-Michael addition. By varying the monomers, the pendant functionality of the polymer chain structure could be altered. All synthesized polymers yield freestanding and easy to handle electrolyte films and hence are evaluated as a new class of SPEs. The SPE with 1,4-butanediol diacrylate and propylamine showed the highest conductivity of 1.15 x 10-7 S cm-1 at 30C with 10 wt% lithium bis(trifluoromethanesulfonyl)imide. Because of the presence of the various functional groups in the structure, the polymer chain aids in the movement of both the anion and the cation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
aza-Michael addition, catalyst-free, LiTFSI, modular, solid polymer electrolyte, solvent-free
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:uu:diva-525664 (URN)10.1002/app.55220 (DOI)001144063000001 ()
Funder
EU, European Research Council, 771777 FUN POLYSTORE
Available from: 2024-03-26 Created: 2024-03-26 Last updated: 2024-03-26Bibliographically approved
Gustafsson, E., Hellsing, M. S., Rennie, A. R., Welbourn, R. J. L., Campana, M., Hughes, A., . . . Melander Bowden, T. (2024). Understanding interactions of plasticisers with a phospholipid monolayer. Soft Matter, 20(13), 2892-2899
Open this publication in new window or tab >>Understanding interactions of plasticisers with a phospholipid monolayer
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2024 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 20, no 13, p. 2892-2899Article in journal (Refereed) Published
Abstract [en]

The use of DEHP (diethylhexyl phthalate) is now banned for most applications in Europe; the exception is for blood bags, where its toxicity is overshadowed by its ability to extend the storage life of red blood cells. Another plasticiser, BTHC (butanoyl trihexyl citrate), is used in paediatric blood bags but does not stabilise blood cells as effectively. Interactions between plasticisers and lipids are investigated with a phospholipid, DMPC, to understand the increased stability of blood cells in the presence of DEHP as well as bioaccumulation and identify differences with BTHC. Mixed monolayers of DMPC and DEHP or BTHC were studied on Langmuir troughs where surface pressure/area isotherms can be measured. Neutron reflection measurements were made to determine the composition and structure of these mixed layers. A large amount of plasticiser can be incorporated into a DMPC monolayer but once an upper limit is reached, plasticiser is selectively removed from the interface at high surface pressures. The upper limit is found to occur between 40–60 mol% for DEHP and 20–40 mol% for BTHC. The areas per molecule are also different with DEHP being in the range of 50–100 Å2 and BTHC being 65–120 Å2. Results indicate that BTHC does not fit as well as DEHP in DMPC monolayers which could help explain the differences observed with regards to the stability of blood cells.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2024
National Category
Other Chemistry Topics Physical Chemistry
Identifiers
urn:nbn:se:uu:diva-525957 (URN)10.1039/d3sm01611k (DOI)001181980700001 ()38465518 (PubMedID)
Funder
Swedish Foundation for Strategic Research, GSn15-0008
Available from: 2024-04-04 Created: 2024-04-04 Last updated: 2024-04-04Bibliographically approved
Bergfelt, A., Hernández, G., Mogensen, R., Lacey, M. J., Mindemark, J., Brandell, D. & Bowden, T. M. (2020). A Mechanical Robust yet highly Conductive Diblock Copolymer-based Solid Polymer Electrolyte for Room Temperature Structural Battery Applications. ACS Applied Polymer Materials, 2(2), 939-948
Open this publication in new window or tab >>A Mechanical Robust yet highly Conductive Diblock Copolymer-based Solid Polymer Electrolyte for Room Temperature Structural Battery Applications
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2020 (English)In: ACS Applied Polymer Materials, ISSN 2637-6105, Vol. 2, no 2, p. 939-948Article in journal (Refereed) Published
Abstract [en]

In this paper we present a solid polymer electrolyte (SPE) that uniquely combines ionic conductivity and mechanical robustness. This is achieved with a diblock copolymer poly(benzyl methacrylate)-poly(ε-caprolactone-r-trimethylene carbonate). The SPE with 16.7 wt% lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) showed the highest ionic conductivity (9.1×10−6 S cm−1 at 30 °C) and apparent transference number (T+) of 0.64 ± 0.04. Due to the employment of the benzyl methacrylate hard-block, this SPE is mechanically robust with a storage modulus (E') of 0.2 GPa below 40 °C, similar to polystyrene, thus making it a suitable material also for load-bearing constructions. The cell Li|SPE|LiFePO4 is able to cycle reliably at 30 °C for over 300 cycles. The promising mechanical properties, desired for compatibility with Li-metal, together with the fact that BCT is a highly reliable electrolyte material makes this SPE an excellent candidate for next-generation all-solid-state batteries.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2020
Keywords
block copolymer, solid polymer electrolyte, lithium-ion battery, structural battery, solid-state battery
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:uu:diva-340855 (URN)10.1021/acsapm.9b01142 (DOI)000514258700088 ()
Funder
Swedish Energy Agency, 40466-1EU, European Research Council, 771777 FUN POLYSTORE
Available from: 2018-02-04 Created: 2018-02-04 Last updated: 2021-04-22Bibliographically approved
Zhou, B., Gao, M., Feng, X., Huang, L., Huang, Q., Kootala, S., . . . Bowden, T. (2020). Carbazate modified dextrans as scavengers for carbonylated proteins. Carbohydrate Polymers, 232, Article ID 115802.
Open this publication in new window or tab >>Carbazate modified dextrans as scavengers for carbonylated proteins
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2020 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 232, article id 115802Article in journal (Refereed) Published
Abstract [en]

A series of biocompatible and non- toxic polysaccharide molecules have been successfully fabricated and explored their potential application for scavenging the carbonyl species in vitro. These macromolecules were dextrans with different hydrazide substitution ratios determined by TNBS assay, NMR and FTIR characterization. The colorimetric assay had demonstrated that these macromolecules could effectively scavenge acrolein, oxidized bovine serum albumin (BSA) in buffer solutions as well as carbonyl proteins from serum. The scavengers could achieve twice more scavenging effects for modified dextrans with high molecular weight (Mw=100,000) than those of low ones (Mw=40,000) with the same substitution ratio. Protein gel electrophoresis confirmed that the formation of the complex between carbonyls and modified dextrans resulted in appearance of slower bands. It also revealed that such macromolecules could protect cultured cells against the toxicity of acrolein or its derivatives. The proposed macromolecules indicated a very promising capability as scavengers for oxidative stress plus its derivatives without side effects.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2020
Keywords
Oxidative stress, Protein carbonyl groups, Human blood serum, Hydrazide-carbonyl click chemistry, Protein gel electrophoresis, Carbonyl scavengers
National Category
Organic Chemistry
Identifiers
urn:nbn:se:uu:diva-405335 (URN)10.1016/j.carbpol.2019.115802 (DOI)000507231800005 ()31952601 (PubMedID)
Available from: 2020-03-04 Created: 2020-03-04 Last updated: 2020-03-04Bibliographically approved
Gustafsson, E., Bowden, T. & Rennie, A. R. (2020). Interactions of amphiphiles with plasticisers used in polymers: Understanding the basis of health and environmental challenges. Advances in Colloid and Interface Science, 277, Article ID 102109.
Open this publication in new window or tab >>Interactions of amphiphiles with plasticisers used in polymers: Understanding the basis of health and environmental challenges
2020 (English)In: Advances in Colloid and Interface Science, ISSN 0001-8686, E-ISSN 1873-3727, Vol. 277, article id 102109Article in journal (Refereed) Published
Abstract [en]

Plasticisers are widely used to provide desirable mechanical properties of many polymeric materials. These small molecule additives are also known to leach from the finished products, and this not only may modify the physical properties but the distribution of these materials in the environment and in the human body can cause long-term health concerns and environmental challenges. Many of these plasticisers are esters of polyvalent acids and phthalic acid has previously been predominant but various alternatives are now being more widely explored. The eventual distribution of these compounds depends not just on solubility in aqueous media and on vapour pressure but also on their interaction with other materials, particularly lipids and amphiphiles. This review provides an overview of both the basic physical data (solubility, partition coefficients, surface tension, vapour pressure) that is available in the literature and summarises what has been learnt about the molecular interactions of various plasticisers with surfactants and lipids.

Place, publisher, year, edition, pages
ELSEVIER, 2020
Keywords
Polyvinyl chloride, Plasticiser, Surfactant, Phthalate esters, Solubility
National Category
Physical Chemistry
Identifiers
urn:nbn:se:uu:diva-408920 (URN)10.1016/j.cis.2020.102109 (DOI)000521512600004 ()32028074 (PubMedID)
Funder
Swedish Foundation for Strategic Research , GSn15-0008
Available from: 2020-04-17 Created: 2020-04-17 Last updated: 2020-04-17Bibliographically approved
Gao, M., Yang, Y., Bergfelt, A., Huang, L., Zheng, L. & Melander Bowden, T. (2020). Self-assembly of cholesterol end-capped polymer micelles for controlled drug delivery. Journal of Nanobiotechnology, 18, Article ID 13.
Open this publication in new window or tab >>Self-assembly of cholesterol end-capped polymer micelles for controlled drug delivery
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2020 (English)In: Journal of Nanobiotechnology, E-ISSN 1477-3155, Vol. 18, article id 13Article in journal (Refereed) Published
Abstract [en]

Background: During the past few decades, drug delivery system (DDS) has attracted many interests because it could enhance the therapeutic effects of drugs and reduce their side effects. The advent of nanotechnology has promoted the development of nanosized DDSs, which could promote drug cellular uptake as well as prolong the half-life in blood circulation. Novel polymer micelles formed by self-assembly of amphiphilic polymers in aqueous solution have emerged as meaningful nanosystems for controlled drug release due to the reversible destabilization of hydrophobic domains under different conditions.

Results: The amphiphilic polymers presented here were composed of cholesterol groups end capped and poly (poly (ethylene glycol) methyl ether methacrylate) (poly (OEGMA)) as tailed segments by the synthesis of cholesterol-based initiator, followed by atom transfer radical polymerization (ATRP) with OEGMA monomer. FT-IR and NMR confirmed the successfully synthesis of products including initiator and polymers as well as the Mw of the polymers were from 33,233 to 89,088 g/mol and their corresponding PDI were from 1.25 to 1.55 by GPC. The average diameter of assembled polymer micelles was in hundreds nanometers demonstrated by DLS, AFM and SEM. The behavior of the amphiphilic polymers as micelles was investigated using pyrene probing to explore their critical micelle concentration (CMC) ranging from 2.53 x 10(-4) to 4.33 x 10(-4) mg/ml, decided by the balance between cholesterol and poly (OEGMA). Besides, the CMC of amphiphilic polymers, the quercetin (QC) feeding ratio and polarity of solvents determined the QC loading ratio maximized reaching 29.2% certified by UV spectrum, together with the corresponding size and stability changes by DLS and Zeta potential, and thermodynamic changes by TGA and DSC. More significantly, cholesterol end-capped polymer micelles were used as nanosized systems for controlled drug release, not only alleviated the cytotoxicity of QC from 8.6 to 49.9% live cells and also achieved the QC release in control under different conditions, such as the presence of cyclodextrin (CD) and change of pH in aqueous solution.

Conclusions: The results observed in this study offered a strong foundation for the design of favorable polymer micelles as nanosized systems for controlled drug release, and the molecular weight adjustable amphiphilic polymer micelles held potential for use as controlled drug release system in practical application.

Place, publisher, year, edition, pages
BMC, 2020
Keywords
Atom transfer radical polymerization, Supermolecular self-assembly, Amphiphilic polymer micelles, Critical micelle concentration, Controlled drug delivery system
National Category
Physical Chemistry Polymer Chemistry
Identifiers
urn:nbn:se:uu:diva-409660 (URN)10.1186/s12951-020-0575-y (DOI)000521249500001 ()31941501 (PubMedID)
Available from: 2020-04-29 Created: 2020-04-29 Last updated: 2024-02-15Bibliographically approved
Yang, Y., Gao, M., Zhou, B., Cai, P., Larsson, T. E., Zhao, J. & Melander Bowden, T. (2020). Weak acidic stable carbazate modified cellulose membranes target for scavenging carbonylated proteins in hemodialysis. Carbohydrate Polymers, 231, Article ID 115727.
Open this publication in new window or tab >>Weak acidic stable carbazate modified cellulose membranes target for scavenging carbonylated proteins in hemodialysis
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2020 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 231, article id 115727Article in journal (Refereed) Published
Abstract [en]

Carbazate groups were grafted on the commercial cellulose membrane (CM) to specifically scavenge the carbonylated proteins for hemodialysis. It confirmed that carbazate groups were successfully covalently attached on the CMs by XPS and EDS, and the modified CMs still saved their original morphology and crystalline structures by SEM and XRD. Furthermore, the modified CMs presented favorable physicochemical stability at wide pH range from 2.5 to 7.4. It was also found that the carbazate modified CMs could selectively remove carbonylated proteins from acrolein treated bovine serum albumin (BSA) or ESRD patient's blood serum in PBS buffer. The modified CMs showed the potential to be utilized as the substitute of dialysis membranes in hemodialysis.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Cellulose membrane, TNBS assay, Carbazate stability, Carbonylated protein, Carbazate- aldehyde/ ketone coupling, Hemodialysis
National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-402393 (URN)10.1016/j.carbpol.2019.115727 (DOI)000504650500059 ()31888849 (PubMedID)
Available from: 2020-01-24 Created: 2020-01-24 Last updated: 2025-02-18Bibliographically approved
Sellberg, F., Fredriksson, F., Engstrand, T., Bowden, T., Nilsson, B., Hong, J., . . . Berglund, D. (2019). Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis. PLOS ONE, 14(12), Article ID e0225777.
Open this publication in new window or tab >>Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis
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2019 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 14, no 12, article id e0225777Article in journal (Refereed) Published
Abstract [en]

Background and objectives: The objective of this study was to investigate whether a soluble polymer and aldehyde-scavenger, polyvinylalcohol-carbazate (PVAC), can inhibit hemolysis in the storage of red blood cells (RBC).

Study design and methods: The effect of PVAC was assessed over a wide range of concentrations, using absorption spectroscopy to evaluate the level of hemolysis. Moreover, osmotic stability and aldehyde-scavenging potential of RBC were assessed after storage in PVAC.

Results: After test tube storage for two weeks, red blood cell hemolysis was lower with PVAC compared to controls (mean difference 23%, 95% CI 16-29%, p < 0.001). A higher level of hemolysis led to a pronounced effect with PVAC. RBC stored in PVAC improved both the binding of free aldehydes (p <0.001) and the osmotic stability (p = 0.0036).

Conclusion: Erythrocytes stored with PVAC showed less hemolysis, which might be explained by the ability of PVACs to stabilize the cell membrane and decrease oxidative injury.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE, 2019
National Category
Biomaterials Science
Identifiers
urn:nbn:se:uu:diva-413440 (URN)10.1371/journal.pone.0225777 (DOI)000534016700008 ()31809514 (PubMedID)
Available from: 2020-06-18 Created: 2020-06-18 Last updated: 2021-06-14Bibliographically approved
Mindemark, J., Lacey, M. J., Bowden, T. & Brandell, D. (2018). Beyond PEO-Alternative host materials for Li+-conducting solid polymer electrolytes. Progress in polymer science, 81, 114-143
Open this publication in new window or tab >>Beyond PEO-Alternative host materials for Li+-conducting solid polymer electrolytes
2018 (English)In: Progress in polymer science, ISSN 0079-6700, E-ISSN 1873-1619, Vol. 81, p. 114-143Article, review/survey (Refereed) Published
Abstract [en]

The bulk of the scientific literature on Li-conducting solid (solvent-free) polymer electrolytes (SPEs) for applications such as Li-based batteries is focused on polyether-based materials, not least the archetypal poly(ethylene oxide) (PEO). A significant number of alternative polymer hosts have, however, been explored over the years, encompassing materials such as polycarbonates, polyesters, polynitriles, polyalcohols and polyamines. These display fundamentally different properties to those of polyethers, and might therefore be able to resolve the key issues restricting SPEs from realizing their full potential, for example in terms of ionic conductivity, chemical or electrochemical stability and temperature sensitivity. It is further interesting that many of these polymer materials complex Li-ions less strongly than PEO and facilitate ion transport through different mechanisms than polyethers, which is likely critical for true advancement in the area. In this review, >30 years of research on these 'alternative' Li-ion-conducting SPE host materials are summarized and discussed in the perspective of their potential application in electrochemical devices, with a clear focus on Li batteries. Key challenges and strategies forward and beyond the current PEO-based paradigm are highlighted.

Keywords
Polymer electrolyte, Solid electrolyte, Li battery, Ionic conductivity, Ion transport
National Category
Materials Chemistry Polymer Technologies
Identifiers
urn:nbn:se:uu:diva-365125 (URN)10.1016/j.progpolymsci.2017.12.004 (DOI)000433643500004 ()
Funder
Swedish Research Council, 2012-3837
Available from: 2018-11-12 Created: 2018-11-12 Last updated: 2018-11-12Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0851-4316

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