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Holmbäck, Ulf
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Publications (10 of 23) Show all publications
Vahlberg, B., Holmbäck, U., Eriksson, S. & Cederholm, T. (2018). Protocol and pilot study of a short message service-guided training after acute stroke/transient ischemic attack to increase walking capacity and physical activity. Preventive medicine reports, 11, 109-114
Open this publication in new window or tab >>Protocol and pilot study of a short message service-guided training after acute stroke/transient ischemic attack to increase walking capacity and physical activity
2018 (English)In: Preventive medicine reports, ISSN 2211-3355, Vol. 11, p. 109-114Article in journal (Refereed) Published
Abstract [en]

Physical activity in community-living individuals after a stroke is usually scarce. This protocol describes a study that will evaluate a method to increase physical activity by performing a 3-month outdoor walking and muscle strengthening program and will examine the 3-month and 1-year effects of this program on individuals with acute stroke (AS) or transient ischemic attack (TIA). In a prospective randomized controlled trial in Uppsala, Sweden, 80 individuals with AS or TIA who maintained cognitive and motor function will be randomized into groups for continuous training for three months or for regular standard care. The training will be supervised by daily cellphone-delivered messages (short message services; SMS), and the intensity, duration and workload will be gradually increased. The primary outcome is a change in walking capacity according to the 6-Minute Walk Test and chair-rising at three months. Secondary outcomes include mobility, gait speed, handgrip strength, body composition (fat mass and muscle mass), biochemical risk-markers, health-related quality of life, and cardiovascular events. Adherence to the training program will be documented with a self-reported diary and step counts over two weeks. The major study started in November 2016, and results are expected in 2019. In a pilot study of 15 subjects post-stroke (mean-age 65 years), we observed improved walking capacity (increasing from 23 to 255 m) and chair-rising (decreasing 2.42 s) from baseline to three months. SMS-guided outdoor training will be tested as a potential therapeutic strategy to increase physical activity and thereby improve walking capacity and physical function following a stroke.

Keywords
Acute stroke, Body composition, Mobility, Physical activity, Transient ischemic attack, Walking capacity
National Category
Physiotherapy
Identifiers
urn:nbn:se:uu:diva-362343 (URN)10.1016/j.pmedr.2018.05.016 (DOI)30023162 (PubMedID)
Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-11-29Bibliographically approved
Skogar, M., Holmbäck, U., Hedberg, J., Risérus, U. & Sundbom, M. (2017). Preserved Fat-Free Mass after Gastric Bypass and Duodenal Switch. Obesity Surgery, 27(7), 1735-1740
Open this publication in new window or tab >>Preserved Fat-Free Mass after Gastric Bypass and Duodenal Switch
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2017 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 27, no 7, p. 1735-1740Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Concerns for the possibility of an excessive loss of fat-free mass (FFM) and resting metabolic rate (RMR) after bariatric surgery, such as Roux-en-Y gastric bypass (RYGB) and duodenal switch (BPD/DS), have been raised.

OBJECTIVES: This study aims to examine body composition and RMR in patients after RYGB and BPD/DS and in non-operated controls.

METHODS: Body composition and RMR were studied with Bod Pod and indirect calorimetry in weight-stable RYGB (n = 15) and BPD/DS patients (n = 12) and compared with non-operated controls (n = 17). All patients were 30-55 years old and weight stable with BMI 28-35 kg/m(2).

RESULTS: FFM% was 58% (RYGB), 61% (BPD/DS), and 58% (controls). Body composition did not differ after RYGB and BPD/DS compared to controls, despite 27 and 40% total body weight loss, respectively. No difference in RMR or RMR/FFM was observed (1539, 1617, and 1490 kcal/24 h; and 28.9, 28.4, and 28.8 kcal/24 h/kg).

CONCLUSION: Weight-stable patients with BMI 28-35 kg/m(2) after RYGB and BPD/DS have a body composition and RMR similar to that of non-operated individuals within the same BMI interval.

National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-310894 (URN)10.1007/s11695-016-2476-6 (DOI)000404529600016 ()27885535 (PubMedID)
Available from: 2016-12-20 Created: 2016-12-20 Last updated: 2019-02-25Bibliographically approved
Johansson, H., Berglund, M. & Holmbäck, U. (2017). Subjective and objective assessment of physical activity - Influence of newly diagnosed exercise induced bronchoconstriction and gender.. Respiratory Medicine, 131, 205-209, Article ID S0954-6111(17)30308-6.
Open this publication in new window or tab >>Subjective and objective assessment of physical activity - Influence of newly diagnosed exercise induced bronchoconstriction and gender.
2017 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 131, p. 205-209, article id S0954-6111(17)30308-6Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate if occurrence of newly diagnosed exercise induced bronchoconstriction (EIB) would affect adolescents' ability to assess their physical activity.

METHODS: 99 selected adolescents with and 47 adolescents without self-reported exercise induced dyspnea were included. All of the 146 adolescents then performed a standardized exercise challenge test on a treadmill with dry-air inhalation to detect EIB. Free living physical activity was assessed during seven days with both accelerometer (objective assessment) and a validated activity diary (subjective assessment). Height, weight and subjective sleep were recorded.

RESULTS: Out of the 146 adolescents 49 were diagnosed with EIB. Forty-six of the adolescents with EIB (35 girls and 11 boys) and 84 of the control adolescents (45 girls and 39 boys) had complete 7 day activity diary and accelerometer data. There were no differences in age, BMI and sleep between EIB and control adolescents. Boys with EIB overestimated subjective assessment compared to objective assessment more than girls with EIB. No difference was seen between control boys and girls. Furthermore, boys with EIB reported a much higher frequency of high intensity exercise than girls with EIB, but no difference was observed between control boys and girls.

CONCLUSION: Adolescent boys with newly diagnosed EIB overestimated their physical activity compared to EIB girls. Caution may thus be used when choosing methods measuring level of physical activity in this group and especially when investigating gender differences.

Keywords
Assessment, Exercise induced bronchoconstriction, Gender, Physical activity
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-334898 (URN)10.1016/j.rmed.2017.08.024 (DOI)000413609200030 ()28947031 (PubMedID)
Funder
Swedish Heart Lung Foundation
Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2018-02-07Bibliographically approved
Holmbäck, U., Berglund, M. & Johansson, H. (2017). Subjective and Objective Assessment of Physical Activity-Influence of Newly Diagnosed Exercise Induced Bronchoconstriction and Gender. Paper presented at Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, APR 22-26, 2017, Chicago, IL. The FASEB Journal, 31
Open this publication in new window or tab >>Subjective and Objective Assessment of Physical Activity-Influence of Newly Diagnosed Exercise Induced Bronchoconstriction and Gender
2017 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 31Article in journal, Meeting abstract (Other academic) Published
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:uu:diva-346187 (URN)000405986500396 ()
Conference
Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, APR 22-26, 2017, Chicago, IL
Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-03-16Bibliographically approved
Sima, E., Holmbäck, U. & Sundbom, M. (2016). Energy Expenditure And Carbohydrate Oxidation In Responders And Non-Responders After Gastric Bypass. Paper presented at 21st World Congress of International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disord ers (IFSO), SEP 28-OCT 01, 2016, Rio de Janeiro, BRAZIL. Obesity Surgery, 26, S82-S83
Open this publication in new window or tab >>Energy Expenditure And Carbohydrate Oxidation In Responders And Non-Responders After Gastric Bypass
2016 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 26, p. S82-S83Article in journal (Refereed) Published
Place, publisher, year, edition, pages
SPRINGER, 2016
Keywords
gastric bypass, metabolism, long-term
National Category
Gastroenterology and Hepatology Surgery
Identifiers
urn:nbn:se:uu:diva-321272 (URN)000398399100047 ()
Conference
21st World Congress of International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disord ers (IFSO), SEP 28-OCT 01, 2016, Rio de Janeiro, BRAZIL
Available from: 2017-05-02 Created: 2017-05-02 Last updated: 2017-05-02Bibliographically approved
Tollerz, L. U. U., Forslund, A. H., Olsson, R. M. M., Lidström, H. & Holmbäck, U. (2015). Children with cerebral palsy do not achieve healthy physical activity levels. Acta Paediatrica, 104(11), 1125-1129
Open this publication in new window or tab >>Children with cerebral palsy do not achieve healthy physical activity levels
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, p. 1125-1129Article in journal (Refereed) Published
Abstract [en]

AimThis study compared daily activity energy expenditure (AEE) in children with cerebral palsy with a control group and investigated whether the children achieved healthy levels of physical activity. MethodsWe enrolled eight children with bilateral cerebral palsy, from eight to 10years of age, and a group of controls matched for age and gender. For three days, physical activity was simultaneously measured by accelerometers and self-reports using a diary. The daily AEE results were compared between groups and methods. The number of children that achieved healthy physical activity levels in each group was explored. ResultsChildren with cerebral palsy had significantly lower daily AEE, as measured by accelerometers, than the controls, and they did not achieve the healthy moderate to heavy physical activity level defined in the Nordic Nutrition Recommendations. Self-reports using the diaries resulted in an overestimation of physical activity compared with the ankle accelerometer measurements in both groups. ConclusionOur investigation of physical activity in children with cerebral palsy and controls using accelerometers and a diary found low levels of daily AEE and physical activity, and these results were most prominent in the group with cerebral palsy. The diaries overestimated physical activity in both groups.

Keywords
Accelerometer, Activity energy expenditure, Cerebral palsy, Children, Physical activity level
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-267657 (URN)10.1111/apa.13141 (DOI)000363866200026 ()
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2017-12-01Bibliographically approved
Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., . . . Cederholm, T. (2015). Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Medical Directors Association, 16(9), 740-747
Open this publication in new window or tab >>Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial
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2015 (English)In: Journal of the American Medical Directors Association, ISSN 1525-8610, E-ISSN 1538-9375, Vol. 16, no 9, p. 740-747Article in journal (Refereed) Published
Abstract [en]

Background: Age-related losses of muscle mass, strength, and function (sarcopenia) pose significant threats to physical performance, independence, and quality of life. Nutritional supplementation could positively influence aspects of sarcopenia and thereby prevent mobility disability. Objective: To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of sarcopenia. Design: A multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic primarily independent-living older adults with Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index. The active group (n = 184) received a vitamin D and leucine-enriched whey protein nutritional supplement to consume twice daily for 13 weeks. The control group (n = 196) received an iso-caloric control product to consume twice daily for 13 weeks. Primary outcomes of handgrip strength and SPPB score, and secondary outcomes of chair-stand test, gait speed, balance score, and appendicular muscle mass (by DXA) were measured at baseline, week 7, and week 13 of the intervention. Results: Handgrip strength and SPPB improved in both groups without significant between-group differences. The active group improved more in the chair-stand test compared with the control group, between-group effect (95% confidence interval): -1.01 seconds (-1.77 to -0.19), P = .018. The active group gained more appendicular muscle mass than the control group, between-group effect: 0.17 kg (0.004-0.338), P = .045. Conclusions: This 13-week intervention of a vitamin D and leucine-enriched whey protein oral nutritional supplement resulted in improvements in muscle mass and lower-extremity function among sarcopenic older adults. This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise. These results warrant further investigations into the role of a specific nutritional supplement as part of a multimodal approach to prevent adverse outcomes among older adults at risk for disability.

Keywords
Sarcopenia, nutritional supplementation, muscle mass, lower extremity function, protein
National Category
Geriatrics
Identifiers
urn:nbn:se:uu:diva-262969 (URN)10.1016/j.jamda.2015.05.021 (DOI)000360320100007 ()26170041 (PubMedID)
Available from: 2015-09-24 Created: 2015-09-23 Last updated: 2018-02-22Bibliographically approved
Holmbäck, U., Berglund, M. & Forslund, A. (2015). No Association between Body Composition and Activity Level in Obese Children and Adolescents Due to Low Overall Activity Level. The FASEB Journal, 29(1 Supplement)
Open this publication in new window or tab >>No Association between Body Composition and Activity Level in Obese Children and Adolescents Due to Low Overall Activity Level
2015 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 29, no 1 SupplementArticle in journal, Meeting abstract (Other academic) Published
National Category
Clinical Medicine Health Sciences
Identifiers
urn:nbn:se:uu:diva-266286 (URN)000361470500366 ()
Available from: 2015-11-06 Created: 2015-11-06 Last updated: 2017-12-01Bibliographically approved
Leproult, R., Holmbäck, U. & Van Canter, E. (2014). Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss. Diabetes, 63(6), 1860-1869
Open this publication in new window or tab >>Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
2014 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 63, no 6, p. 1860-1869Article in journal (Refereed) Published
Abstract [en]

Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss.

National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-228005 (URN)10.2337/db13-1546 (DOI)000336643900014 ()
Available from: 2014-07-03 Created: 2014-07-02 Last updated: 2017-12-05Bibliographically approved
Klingenberg, L., Chaput, J.-P., Holmbäck, U., Visby, T., Jennum, P., Nikolic, M., . . . Sjodin, A. (2013). Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys. Sleep, 36(7), 1085-1090
Open this publication in new window or tab >>Acute Sleep Restriction Reduces Insulin Sensitivity in Adolescent Boys
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2013 (English)In: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 36, no 7, p. 1085-1090Article in journal (Refereed) Published
Abstract [en]

Background: Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction. Objective: We aimed to investigate the effects of partial sleep deprivation on markers of glucose metabolism. Additionally, we aimed to investigate if short sleep duration induces a state of endocrine stress. Design: A randomized crossover design, with 2 experimental conditions: 3 consecutive nights of short sleep (SS, 4 h/night) and long sleep (LS, 9 h/night) duration. Subjects and Measurements: In 21 healthy, normal-weight male adolescents (mean +/- SD age: 16.8 +/- 1.3 y) we measured pre- and post-prandial glucose, insulin, C-peptide, and glucagon concentrations. Furthermore, we measured fasting cortisol, 24-h catecholamines, and sympathovagal balance. Results: Fasting insulin was 59% higher (P = 0.001) in the SS than the LS condition as was both fasting (24%, P < 0.001) and post-prandial (11%, P = 0.018) C-peptide. Pre- and post-prandial glucose and glucagon were unchanged between conditions. The homeostasis model assessment of insulin resistance (HOMA-IR) index was 65% higher (P = 0.002) and the Matsuda index was 28% lower (P = 0.007) in the SS condition compared to the LS condition. The awakening cortisol response and 24-h norepinephrine were not affected by sleep duration, whereas 24-h epinephrine was 24% lower (P = 0.013) in the SS condition. Neither daytime nor 24-h sympathovagal balance differed between sleep conditions. Short wave sleep was preserved in the SS condition. Conclusion: Short-term sleep restriction is associated with decreased insulin sensitivity in healthy normal-weight adolescent boys. There were no indications of endocrine stress beyond this.

Keywords
Sleep deprivation, sleep quality, glucose metabolism, teenagers
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-204274 (URN)10.5665/sleep.2816 (DOI)000321039500019 ()
Available from: 2013-07-30 Created: 2013-07-29 Last updated: 2017-12-06Bibliographically approved
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