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Diouf, A., Moufid, M., Bouyahya, D., Österlund, L., El Bari, N. & Bouchikhi, B. (2020). An electrochemical sensor based on chitosan capped with gold nanoparticles combined with a voltammetric electronic tongue for quantitative aspirin detection in human physiological fluids and tablets. Materials science & engineering. C, biomimetic materials, sensors and systems, 110, Article ID 110665.
Open this publication in new window or tab >>An electrochemical sensor based on chitosan capped with gold nanoparticles combined with a voltammetric electronic tongue for quantitative aspirin detection in human physiological fluids and tablets
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2020 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 110, article id 110665Article in journal (Refereed) Published
Abstract [en]

Inflammatory diseases increase has recently sparked the research interest for drugs diagnostic tools development. At therapeutic doses, acetylsalicylic acid (ASA or aspirin) is widely used for these diseases' treatment. ASA overdoses can however give rise to adverse side effects including ulcers, gastric damage. Hence, development of simple, portable and sensitive methods for ASA detection is desirable. This paper reports aspirin analysis in urine, saliva and pharmaceutical tablet using an electrochemical sensor and a voltammetric electronic tongue (VE-Tongue). The electrochemical sensor was fabricated by self-assembling chitosan capped with gold nanoparticles (Cs + AuNPs) on a screen-printed carbon electrode (SPCE). It exhibits a logarithmic-linear relationship between its response and the ASA concentration in the range between 1 pg/mL and 1 mu g/mL. A low detection limit (0.03 pg/mL), good selectivity against phenol and benzoic acid interference, and successful practical application were demonstrated. Qualitative analysis was performed using the VE-Tongue based unmodified metal electrodes combined with two chemometric approaches to classify urine samples spiked with different aspirin concentrations. Partial least squares (PLS) method provided prediction models obtained from the data of both devices with a regression correlation coefficient R-2 = 0.99. Correspondingly, the SPCE/(Cs + AuNPs) electrochemical sensor and VE-Tongue could be viable tools for biological analysis of drugs.

Place, publisher, year, edition, pages
ELSEVIER, 2020
Keywords
Aspirin, Electrochemical sensor, Human fluids, Multivariate data analysis, Voltammetric electronic tongue
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:uu:diva-411439 (URN)10.1016/j.msec.2020.110665 (DOI)000527395900040 ()32204094 (PubMedID)
Funder
EU, Horizon 2020, 645758
Available from: 2020-06-02 Created: 2020-06-02 Last updated: 2020-06-02Bibliographically approved
Aghoutane, Y., Diouf, A., Österlund, L., Bouchikhi, B. & El Bari, N. e. (2020). Development of a molecularly imprinted polymer electrochemical sensor and its application for sensitive detection and determination of malathion in olive fruits and oils. Bioelectrochemistry, 132, Article ID 107404.
Open this publication in new window or tab >>Development of a molecularly imprinted polymer electrochemical sensor and its application for sensitive detection and determination of malathion in olive fruits and oils
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2020 (English)In: Bioelectrochemistry, ISSN 1567-5394, E-ISSN 1878-562X, Vol. 132, article id 107404Article in journal (Refereed) Published
Abstract [en]

Malathion (MAL) is an organophosphorus (OP) insecticide. It is a cholinesterase inhibitor, 15 which can pose serious health and environmental problems. In this study, a sensitive and 16 selective molecular imprinted polymer (MIP) based on screen-printed gold electrodes (Au-17 SPE) for MAL detection in olive oils and fruits, was devised. The MIP sensor was prepared 18 using acrylamide as the functional monomer and MAL as the template. Subsequently, the 19 morphology of the electrode surface was studied by scanning electron microscopy (SEM) and 20 atomic force microscopy (AFM). The electrochemical characterization of the developed MIP 21 sensor was performed by cyclic voltammetry (CV), differential pulse voltammetry (DPV), 22 and electrochemical impedance spectroscopy (EIS) techniques. The operational repeatability 23 and stability of the sensor were studied. It was found to have a dynamic concentration range 24 of (0.1 pg mL-1-1000 pg mL-1) and a low limit of detection (LOD) of 0.06 pg mL-1. 25 Furthermore, the sensor was employed to determine MAL content in olive oil with a recovery 26 rate of 87.9% and a relative standard deviation of 8%. It was successfully applied for MAL 27 determination in real samples and promise to open new opportunities for the detection of OP 28 pesticides residues in various food products, as well as in environmental applications.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Molecularly imprinted polymer; Screen printed gold electrode; Electrochemical 30 sensor; Malathion; Olive oils; olive fruits
National Category
Analytical Chemistry
Research subject
Chemistry with specialization in Analytical Chemistry; Engineering Science with specialization in Materials Science
Identifiers
urn:nbn:se:uu:diva-396759 (URN)10.1016/j.bioelechem.2019.107404 (DOI)000518670600029 ()31911357 (PubMedID)
Funder
EU, Horizon 2020, 645758
Available from: 2019-11-08 Created: 2019-11-08 Last updated: 2020-04-06Bibliographically approved
Welearegay, T., Duran-Acevedo, C. M., Jaimes-Mogollon, A. L., Pugliese, G., Ionescu, F., Perez-Ortiz, O. G., . . . Ionescu, R. (2020). Exhaled air analysis as a potential fast method for early diagnosis of dengue disease. Sensors and actuators. B, Chemical, 310, Article ID 127859.
Open this publication in new window or tab >>Exhaled air analysis as a potential fast method for early diagnosis of dengue disease
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2020 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 310, article id 127859Article in journal (Refereed) Published
Abstract [en]

Dengue is a neglected tropical disease caused by arbovirus. Every year 390 million persons are infected with dengue, of which 96 million manifest clinically around the world, mainly in the Latin America, South-East Asia and Western Pacific. The disease manifests itself as a flu-like infection that generally is difficult to recognise from a normal flu or other viral infections. The mortality rate is around 20 % for the severe form of dengue, which readily could be decreased to below 1% with early, reliable diagnostic tools. Today there exist however no diagnostic tests for the early and rapid diagnosis of this disease. In this study, we report for the first time the possibility of identification of possible biomarkers associated with dengue disease in the exhaled air, and of the development of a breath test for fast, non-invasive and easy diagnosis of this disease. Further, we demonstrate a new deployable sensor technology based on a chemoresistive metal-ligand nanoassembly tailored for the identified possible biomarkers of dengue disease, which achieved 100 % accuracy for dengue diagnosis on our study group and can be used in both specialist and non-specialist settings. Nevertheless, as the present study was performed on a limited number of patients because of the difficulty to recruit a high number of patients because dengue is a neglected disease, future validation tests on a higher cohort are necessary for corroborating the results obtained in the present study.

Place, publisher, year, edition, pages
Netherlands: , 2020
Keywords
Dengue disease; Breath analysis; Biomarkers; Chemical gas sensors; Ligand-capped metal nanoparticles
National Category
Other Chemical Engineering Other Materials Engineering
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Solid State Physics; Engineering Science
Identifiers
urn:nbn:se:uu:diva-405507 (URN)10.1016/j.snb.2020.127859 (DOI)000519306300023 ()
Funder
EU, Horizon 2020, 645758
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2020-04-09Bibliographically approved
Cindemir, U., Topalian, Z., Granqvist, C. G., Österlund, L. & Niklasson, G. (2019). Characterization of nanocrystalline-nanoporous nickel oxide thin films prepared by reactive advanced gas deposition. Materials Chemistry and Physics, 227, 98-104
Open this publication in new window or tab >>Characterization of nanocrystalline-nanoporous nickel oxide thin films prepared by reactive advanced gas deposition
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2019 (English)In: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 227, p. 98-104Article in journal (Refereed) Published
Abstract [en]

Nanocrystalline-nanoporous Ni oxide is of much interest for gas sensors and other applications. Reactive advanced gas deposition (AGD) stands out as a particularly promising technique for making thin films of this material owing to the techniques ability to separate between the growth of individual nanoparticles and their subsequent deposition to create a consolidated material on a substrate. Here we report on the characterization of Ni oxide films, made by reactive AGD, by several methods. X-ray diffractometry showed that the films had a face centered cubic NiO structure, and scanning electron microscopy indicated a compact nanoparticulate composition. X-ray photoelectron spectroscopy showed the presence of Ni3+ and demonstrated that these states became less prominent upon heat treatment in air. Extended x-ray absorption fine structure analysis elucidated the local atomic structure; in particular, data on interatomic distances and effects of annealing on local disorder showed that the Ni oxide nanoparticles crystallize upon annealing while maintaining their nanoparticle morphology, which is a crucial feature for reproducible fabrication of Ni oxide thin films for gas sensors. Importantly, several techniques demonstrated that grain growth remained modest for annealing temperatures as high as 400 degrees C for 1700-nm-thick films. The present article is a sequel to an earlier one [U. Cindemir et al., Sensors and Actuators B 242 (2017) 132-139] in which we reported on fluctuation-enhanced and conductometric gas sensing with Ni oxide films prepared by AGD.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2019
Keywords
Nickel oxide, Advanced gas deposition, EXAFS, Atomic structure, Gas sensor
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-387223 (URN)10.1016/j.matchemphys.2019.01.058 (DOI)000466617800013 ()
Funder
EU, FP7, Seventh Framework Programme, 267234
Available from: 2019-06-25 Created: 2019-06-25 Last updated: 2020-04-14Bibliographically approved
Geremariam Welearegay, T., Diouani, M. F., Österlund, L., Borys, S., Khaled, S., Smadhi, H., . . . Ionescu, R. (2019). Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths. Journal of Infectious Diseases, 219(1), 101-109
Open this publication in new window or tab >>Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths
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2019 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 219, no 1, p. 101-109Article in journal (Refereed) Published
Abstract [en]

Background: Human echinococcosis is a neglected infectious disease affecting more than 1 million people globally. Its diagnosis is expensive and difficult because of lack of adequate resources in low-resource locations, where most cases occur.

Methods: A group of volunteers diagnosed with the 2 main types of echinococcosis and corresponding control groups were recruited from hospitals in Tunisia (32 patients with cystic echinococcosis and 43 controls) and Poland (16 patients with alveolar echinococcosis and 8 controls). Breath samples were collected from all patients and analyzed by gas chromatography coupled to mass spectrometry, and a specifically developed electronic nose system.

Results: The chemical analysis revealed statistically different concentrations of 2 compounds in the breath of patients with cystic echinococcosis compared to controls, and statistically different concentrations of 7 compounds in the breath of patients with alveolar echinococcosis compared to controls. The discrimination accuracy achieved by the electronic nose system was 100% for cystic echinococcosis and 92.9% for alveolar echinococcosis, while the discrimination accuracy between these 2 patient groups was 92.1%.

Conclusion: Here we advocate a noninvasive, fast, easy-to-operate and nonexpensive diagnostic tool for the diagnosis of human echinococcosis disease through exhaled breath analysis, suitable for early diagnosis and population screening.

Keywords
echinococcosis, diagnosis, breath analysis, biomarkers, chemical sensors
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-378686 (URN)10.1093/infdis/jiy449 (DOI)000458610200014 ()30016445 (PubMedID)
Funder
EU, Horizon 2020, 645758
Available from: 2019-03-12 Created: 2019-03-12 Last updated: 2020-02-18Bibliographically approved
Arvizu, M. A., Qu, H.-Y., Cindemir, U., Qiu, Z., Rojas González, E. A., Primetzhofer, D., . . . Niklasson, G. (2019). Electrochromic WO3 thin films attain unprecedented durability by potentiostatic pretreatment. Journal of Materials Chemistry A, 7(6), 2908-2918
Open this publication in new window or tab >>Electrochromic WO3 thin films attain unprecedented durability by potentiostatic pretreatment
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2019 (English)In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 7, no 6, p. 2908-2918Article in journal (Refereed) Published
Abstract [en]

Electrochromic windows and glass facades are able to impart energy efficiency jointly with indoor comfort and convenience. Long-term durability is essential for practical implementation of this technology and has recently attracted broad interest. Here we show that a simple potentiostatic pretreatment of sputterdeposited thin films of amorphous WO3-the most widely studied electrochromic material-can yield unprecedented durability for charge exchange and optical modulation under harsh electrochemical cycling in a Li-ion-conducting electrolyte and effectively evades harmful trapping of Li. The pretreatment consisted of applying a voltage of 6.0 V vs. Li/Li+ for several hours to a film backed by a transparent conducting In2O3: Sn layer. Associated compositional and structural modifications were probed by several techniques, and improved durability was associated with elemental intermixing at the WO3/ITO and ITO/glass boundaries as well as with carbonaceous solid-electrolyte interfacial layers on the WO3 films. Our work provides important new insights into long-term durability of ion-exchange-based devices.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2019
National Category
Materials Chemistry
Identifiers
urn:nbn:se:uu:diva-378529 (URN)10.1039/c8ta09621j (DOI)000457893400054 ()
Funder
EU, European Research Council, 267234Swedish Research Council, 821-2012-5144Swedish Research Council, 2017-00646_9Swedish Foundation for Strategic Research , RIF14-0053
Available from: 2019-03-22 Created: 2019-03-22 Last updated: 2019-03-22Bibliographically approved
Thyr, J., Österlund, L. & Edvinsson, T. (2019). Photocatalytic properties and polarized Raman of different ZnO crystal planes. In: : . Paper presented at E-MRS Spring Meeting 2019, Symposium H, Materials for applications in photocatalysis and photoconversion.
Open this publication in new window or tab >>Photocatalytic properties and polarized Raman of different ZnO crystal planes
2019 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Zinc oxide (ZnO) is a well-studied wide band gap semiconductor photocatalyst. The activities of ZnO nanomaterials with different ratios of exposed crystal planes are however less understood. In this work, three different ZnO single crystals exposing different crystal planes were studied: (0001), (1-100), and (11-20). The ZnO samples were characterized with polarized Raman spectroscopy and XRD, and their photocatalytic activities were quantified by means of methylene blue degradation using in situ spectrophotometry. The ZnO (1-100) surface showed three times higher photocatalytic activity than the other two surfaces. The results are discussed in terms of crystal facet dependent reactivity due to differences in surface structure and surface potential. Since it is possible to synthesize ZnO particles and structures with different ratios of exposed crystal planes, this finding may be of importance to guide synthesis of more efficient, tailor-made ZnO photocatalysts for water cleaning.

Keywords
Zinc oxide, Photocatalysis, Polarized Raman Spectroscopy
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-397294 (URN)
Conference
E-MRS Spring Meeting 2019, Symposium H, Materials for applications in photocatalysis and photoconversion
Funder
Swedish Research Council Formas, 2016-00908
Available from: 2019-11-19 Created: 2019-11-19 Last updated: 2019-11-19
Henycha, J., Stehlik, S., Mazanec, K., Tolasz, J., Cermak, J., Rezek, B., . . . Österlund, L. (2019). Reactive adsorption and photodegradation of soman and dimethyl methylphosphonate on TiO2/nanodiamond composites. Applied Catalysis B: Environmental, 259, Article ID UNSP 118097.
Open this publication in new window or tab >>Reactive adsorption and photodegradation of soman and dimethyl methylphosphonate on TiO2/nanodiamond composites
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2019 (English)In: Applied Catalysis B: Environmental, ISSN 0926-3373, E-ISSN 1873-3883, Vol. 259, article id UNSP 118097Article in journal (Refereed) Published
Abstract [en]

We report on the synthesis and characterization of TiO2/Nanodiamond (ND) nanocomposites for rapid decontamination of chemical warfare agents (CWA) and toxic industrial compounds prepared by a simple water-based, low-temperature method using urea as a homogeneous precipitating agent. The excellent water-compatibility of NDs promoted their good dispersion within the TiO2 matrix resulting in intergrown TiO2/ND nanostructures. NDs with an abundance of oxygen-containing surface moieties increased the porosity of the composites resulting in their three times more efficient spontaneous degradation of the CWA soman in solution compared to pure TiO2. In situ DRIFT spectroscopy revealed the enhanced reactive adsorption and solar light photodecomposition of dimethyl methyl phosphonate vapor on TiO2/ND. The charge transfer across TiO2/ND interfaces that hinder recombination of photo-excited electron-hole pairs was inferred from surface potential measurements. The results indicate that well-dispersed NDs forming heterojunctions together with their high porosity contribute to the reactive properties of the nanocomposites.

Place, publisher, year, edition, pages
ELSEVIER, 2019
Keywords
Titanium dioxide, Nanodiamond, Nanocomposites, Photocatalysis, Chemical warfare agents
National Category
Materials Engineering Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-395711 (URN)10.1016/j.apcatb.2019.118097 (DOI)000488308800069 ()
Funder
Swedish Research Council, 2016-05904
Note

Correction in: APPLIED CATALYSIS B-ENVIRONMENTAL, Volume: 261, Article Number: 118263, DOI: 10.1016/j.apcatb.2019.118263

Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-12-11Bibliographically approved
Henych, J., Mattsson, A., Tolasz, J., Stengl, V. & Österlund, L. (2019). Solar light decomposition of warfare agent simulant DMMP on TiO2/graphene oxide nanocomposites. Catalysis Science & Technology, 9(8), 1816-1824
Open this publication in new window or tab >>Solar light decomposition of warfare agent simulant DMMP on TiO2/graphene oxide nanocomposites
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2019 (English)In: Catalysis Science & Technology, ISSN 2044-4753, E-ISSN 2044-4761, Vol. 9, no 8, p. 1816-1824Article in journal (Refereed) Published
Abstract [en]

Solar light-induced photodecomposition of organophosphorus warfare agent simulant dimethyl methylphosphonate (DMMP) on the surfaces of TiO2/graphene oxide (GO) nanocomposites was studied by in situ DRIFT spectroscopy. Nanocomposites containing 1 and 2 wt% GO, respectively, were prepared by two different aqueous methods. All nanocomposites were shown to effectively adsorb and partly dissociate DMMP as shown by the formation of surface coordinated methoxy groups. Solar light illumination induced rapid decomposition of the adsorbed species to yield various ionic and surface coordinated formate and carbonate species as the main intermediate products. Both the kinetics of adsorbed species decomposition and the formation of various intermediates were strongly affected by the presence of GO, as compared to pure TiO2 nanoparticles. The two synthesis routes yielded nanocomposites with different degrees of reduction of GO that correlated with their reactivity towards DMMP adsorption and photodegradation. Upon illumination, rapid depletion of water was observed on the TiO2/GO nanocomposites and was attributed to a water splitting reaction, which competed with the DMMP photo-oxidation reaction.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2019
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-383187 (URN)10.1039/c9cy00059c (DOI)000465404200007 ()
Funder
Swedish Research Council, 2016-05904
Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2020-02-18Bibliographically approved
Österlund, L., Mattsson, A., Ji, Y.-X. -., Niklasson, G. A. & Granqvist, C.-G. (2019). Spectrally selective nanocoatings with synergistically enhanced photocatalytic and solar light modulation properties. In: : . Paper presented at E-MRS Spring Meeting 2019. IUMRS-ICAM International Conference on Advanced Materials, May 27-31, 2019, Nice, France..
Open this publication in new window or tab >>Spectrally selective nanocoatings with synergistically enhanced photocatalytic and solar light modulation properties
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2019 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Spectrally selective nanocoatings that exhibit synergistically enhanced solar light modulation, luminous transmittance and catalytic properties can be made by combining dielectric film stacks with complementary optical and structural properties. Here we show two case studies:

1)TiO2/VO2 luminous transparent bilayers that exhibits enhanced near-infrared light absorption and heats the TiO2 film by up to ~ 30°C  resulting in ~ 2-fold increase of the photocatalytic reaction rate. The TiO2/VO2 bilayer stack exhibits anti-reflective properties, and enhanced solar light modulation (∼ 9%) compared to VO2, and ∼ 20 times% increased solar absorptance compared to TiO2. In addition the TiO2 chemically protects the VO2 layer avoiding oxidation to vanadium pentoxide. 2)TiO2/TiAlN solar absorber bilayers that yield an almost ~ 10-fold enhancement of the quantum yield for acetaldehyde removal (on par with state-of-the-art, heterojunction photocatalysts), and an associated temperature rise ~120 °C.

National Category
Engineering and Technology Physical Sciences
Research subject
Engineering Science with specialization in Solid State Physics
Identifiers
urn:nbn:se:uu:diva-395216 (URN)
Conference
E-MRS Spring Meeting 2019. IUMRS-ICAM International Conference on Advanced Materials, May 27-31, 2019, Nice, France.
Available from: 2019-10-15 Created: 2019-10-15 Last updated: 2019-10-21Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-0296-5247

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