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BETA
Antoni, Gunnar
Alternative names
Publications (10 of 149) Show all publications
Gonzalez, M. A. C., Nordeman, P., Gomez, A. B., Meyer, D. N., Antoni, G., Schou, M. & Szabo, K. J. (2018). [18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling. Chemical Communications, 54(34), 4286-4289
Open this publication in new window or tab >>[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling
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2018 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 54, no 34, p. 4286-4289Article in journal (Refereed) Published
Abstract [en]

Operationally simple radiosynthesis and purification of [F-18]fluoro-benziodoxole was developed starting from a cyclotron produced [F-18]F- precursor, [F-18]TBAF, and tosyl-benziodoxole. The synthetic utility of [F-18]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50-90%) and high molar activity (up to 396 GBq mol(-1)).

National Category
Organic Chemistry
Identifiers
urn:nbn:se:uu:diva-354948 (URN)10.1039/c8cc00526e (DOI)000430935200013 ()29632936 (PubMedID)
Funder
VINNOVASwedish Research Council
Available from: 2018-06-25 Created: 2018-06-25 Last updated: 2018-06-25Bibliographically approved
Coenena, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., . . . Windhorst, A. D. (2018). International Consensus Radiochemistry Nomenclature Guidelines [Letter to the editor]. Nuclearmedizin, 57(1), 40-41
Open this publication in new window or tab >>International Consensus Radiochemistry Nomenclature Guidelines
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2018 (English)In: Nuclearmedizin, ISSN 0029-5566, Vol. 57, no 1, p. 40-41Article in journal, Letter (Refereed) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-351600 (URN)10.1055/s-0038-1636563 (DOI)000426117600008 ()29536500 (PubMedID)
Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2018-06-01Bibliographically approved
Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., . . . Windhorst, A. D. (2018). Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines [Letter to the editor]. American Journal of Nuclear Medicine and Molecular Imaging, 8(1), 70-72
Open this publication in new window or tab >>Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines
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2018 (English)In: American Journal of Nuclear Medicine and Molecular Imaging, ISSN 2160-8407, Vol. 8, no 1, p. 70-72Article in journal, Letter (Other academic) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-352929 (URN)000426585200007 ()29531863 (PubMedID)
Available from: 2018-06-08 Created: 2018-06-08 Last updated: 2018-06-08Bibliographically approved
Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., . . . Windhorst, A. D. (2018). Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines [Letter to the editor]. Nuclear medicine communications, 39(3), 193-195
Open this publication in new window or tab >>Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines
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2018 (English)In: Nuclear medicine communications, ISSN 0143-3636, E-ISSN 1473-5628, Vol. 39, no 3, p. 193-195Article in journal, Letter (Other academic) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-355829 (URN)10.1097/MNM.0000000000000799 (DOI)000427035300001 ()29438216 (PubMedID)
Available from: 2018-07-13 Created: 2018-07-13 Last updated: 2018-07-13Bibliographically approved
Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., . . . Windhorst, A. D. (2018). Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines [Letter to the editor]. Annals of Nuclear Medicine, 32(3), 236-238
Open this publication in new window or tab >>Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines
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2018 (English)In: Annals of Nuclear Medicine, ISSN 0914-7187, E-ISSN 1864-6433, Vol. 32, no 3, p. 236-238Article in journal, Letter (Other academic) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-356227 (URN)10.1007/s12149-018-1238-z (DOI)000427631800009 ()29423765 (PubMedID)
Available from: 2018-07-19 Created: 2018-07-19 Last updated: 2018-07-19Bibliographically approved
Coenen, H. H., Gee, A. D., Adam, M., Antoni, G., Cutler, C. S., Fujibayashi, Y., . . . Windhorst, A. D. (2018). Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines [Letter to the editor]. Journal of Radioanalytical and Nuclear Chemistry, 315(3), 443-445
Open this publication in new window or tab >>Open letter to journal editors on: international consensus radiochemistry nomenclature guidelines
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2018 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 315, no 3, p. 443-445Article in journal, Letter (Other academic) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-351590 (URN)10.1007/s10967-017-5693-0 (DOI)000426219900001 ()
Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2018-07-19Bibliographically approved
Pilebro, B., Arvidsson, S., Lindqvist, P., Sundström, T., Westermark, P., Antoni, G., . . . Sörensen, J. (2018). Positron emission tomography (PET) utilizing Pittsburgh compound B (PIB) for detection of amyloid heart deposits in hereditary transthyretin amyloidosis (ATTR). Journal of Nuclear Cardiology, 25(1), 240-248
Open this publication in new window or tab >>Positron emission tomography (PET) utilizing Pittsburgh compound B (PIB) for detection of amyloid heart deposits in hereditary transthyretin amyloidosis (ATTR)
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2018 (English)In: Journal of Nuclear Cardiology, ISSN 1071-3581, E-ISSN 1532-6551, Vol. 25, no 1, p. 240-248Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: DPD scintigraphy has been advocated for imaging cardiac amyloid in ATTR amyloidosis. PET utilizing (11)C-Pittsburgh compound B (PIB) is the gold standard for imaging brain amyloid in Alzheimer's disease. PIB was recently shown to identify cardiac amyloidosis in both AL and ATTR amyloidosis. In the ATTR population, two types of amyloid fibrils exist, one containing fragmented and full-length TTR (type A) and the other only full-length TTR (type B). The aim of this study was to further evaluate PIB-PET in patients with hereditary ATTR amyloidosis.

METHODS: Ten patients with biopsy-proven V30M ATTR amyloidosis and discrete or no signs of cardiac involvement were included. Patients were grouped according to TTR-fragmentation. All underwent DPD scintigraphy, echocardiography, and PIB-PET. A left ventricular PIB-retention index (PIB-RI) was established and compared to five normal volunteers.

RESULTS: PIB-RI was increased in all patients (P < 0.001), but was significantly higher in type B than in type A (0.129 ± 0.041 vs 0.040 ± 0.006 min(-1), P = 0.009). Cardiac DPD uptake was elevated in group A and absent in group B.

CONCLUSION: PIB-PET, in contrast to DPD scintigraphy, has the potential to specifically identify cardiac amyloid depositions irrespective of amyloid fibril composition. The heart appears to be a target organ for amyloid deposition in ATTR amyloidosis.

Keywords
Cardiomyopathy, Pittsburgh compound B, amyloidosis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-319475 (URN)10.1007/s12350-016-0638-5 (DOI)000423585200038 ()27645889 (PubMedID)
Funder
Swedish Heart Lung FoundationVästerbotten County Council
Available from: 2017-04-05 Created: 2017-04-05 Last updated: 2018-03-14Bibliographically approved
Syvänen, S., Fang, X. T., Hultqvist, G., Falting, J., Antoni, G., Lannfelt, L. & Sehlin, D. (2017). Antibody-based PET radioligands for imaging of amyloid-beta protofibrils. Paper presented at 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, APR 01-04, 2017, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY. Journal of Cerebral Blood Flow and Metabolism, 37, 84-84
Open this publication in new window or tab >>Antibody-based PET radioligands for imaging of amyloid-beta protofibrils
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2017 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, Vol. 37, p. 84-84Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sage Publications, 2017
National Category
Endocrinology and Diabetes Hematology Neurology
Identifiers
urn:nbn:se:uu:diva-331033 (URN)000400157400120 ()
Conference
28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, APR 01-04, 2017, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY
Note

Supplement: 1, Meeting Abstract: BPS04-1.

Available from: 2017-10-11 Created: 2017-10-11 Last updated: 2017-10-11
Andersen, T. L., Nordeman, P., Christoffersen, H. F., Audrain, H., Antoni, G. & Skrydstrup, T. (2017). Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N-C-11-Acetylation of Peptides. Angewandte Chemie International Edition, 56(16), 4549-4553
Open this publication in new window or tab >>Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N-C-11-Acetylation of Peptides
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2017 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 56, no 16, p. 4549-4553Article in journal (Refereed) Published
Abstract [en]

A mild and effective method is described for C-11-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [C-11] carbon monoxide. The protocol facilitates the production of native N-C-11-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.

Keywords
C-11-labeling, carbonylation, palladium, peptides
National Category
Chemical Sciences
Identifiers
urn:nbn:se:uu:diva-320628 (URN)10.1002/anie.201700446 (DOI)000398154000026 ()28301077 (PubMedID)
Funder
Danish National Research Foundation, DNRF118
Note

De 2 sista författarna delar sistaförfattarskapet.

Available from: 2017-08-14 Created: 2017-08-14 Last updated: 2017-08-14Bibliographically approved
Elgland, M., Nordeman, P., Fyrner, T., Antoni, G., Nilsson, K. P. & Konradsson, P. (2017). beta-Configured clickable [F-18] FDGs as novel F-18-fluoroglycosylation tools for PET. New Journal of Chemistry, 41(18), 10231-10236
Open this publication in new window or tab >>beta-Configured clickable [F-18] FDGs as novel F-18-fluoroglycosylation tools for PET
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2017 (English)In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 41, no 18, p. 10231-10236Article in journal (Refereed) Published
Abstract [en]

In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) is by far the most commonly employed metabolic imaging agent for positron emission tomography (PET). Herein, we report a novel synthetic route to beta-configured mannopyranoside precursors and a chemoselective F-18-fluoroglycosylation method that employ two b-configured [F-18]FDG derivatives equipped with either a terminal azide or alkyne aglycon respectively, for use as a CuAAC clickable tool set for PET. The b-configured precursors provided the corresponding [F-18]FDGs in a radiochemical yield of 77-88%. Further, the clickability of these [F-18]FDGs was investigated by click coupling to the suitably functionalized Fmoc-protected amino acids, Fmoc-N-(propargyl)-glycine and Fmoc-3-azido-L-alanine, which provided the F-18-fluoroglycosylated amino acid conjugates in radiochemical yields of 75-83%. The F-18-fluoroglycosylated amino acids presented herein constitute a new and interesting class of metabolic PET radiotracers.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2017
National Category
Chemical Sciences
Identifiers
urn:nbn:se:uu:diva-336822 (URN)10.1039/c7nj00716g (DOI)000411767400073 ()
Funder
Swedish Foundation for Strategic Research Swedish Research Council
Available from: 2017-12-20 Created: 2017-12-20 Last updated: 2017-12-20Bibliographically approved
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