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Amini, Hashem
Publications (6 of 6) Show all publications
Canto Moreira, N., Teixeira, J., Themudo, R., Amini, H., Axelsson, O., Raininko, R. & Wikström, J. (2011). Measurements of the normal fetal brain at gestation weeks 17 to 23: a MRI study. Neuroradiology, 53(1), 43-48
Open this publication in new window or tab >>Measurements of the normal fetal brain at gestation weeks 17 to 23: a MRI study
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2011 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 53, no 1, p. 43-48Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: To obtain measurements of the normal fetal brain before 24 weeks of gestation (GW), a deadline for medical decisions on fetal viability in a large number of countries. METHODS: We retrospectively reviewed 70 normal MR examinations of fetuses aged GW 17 to 23. The fronto-occipital diameter, the cerebral bi-parietal diameter, the transverse cerebellar diameter, the vermian height, and antero-posterior diameter were measured. RESULTS: The median, maximum, and minimum values for each parameter were displayed for each individual GW. CONCLUSION: The recorded data might contribute to a better assessment of fetal health by providing normal boundaries for the brain growth.

Keywords
Biometry, Brain, Fetal, MRI, Normal development
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-132616 (URN)10.1007/s00234-010-0772-8 (DOI)000285878200008 ()20878397 (PubMedID)
Available from: 2010-10-22 Created: 2010-10-22 Last updated: 2017-12-12Bibliographically approved
Amini, H., Wikström, J., Ahlström, H. & Axelsson, O. (2011). Second trimester fetal magnetic resonance imaging improves diagnosis of non-central nervous system anomalies. Acta Obstetricia et Gynecologica Scandinavica, 90(4), 380-389
Open this publication in new window or tab >>Second trimester fetal magnetic resonance imaging improves diagnosis of non-central nervous system anomalies
2011 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 90, no 4, p. 380-389Article in journal (Refereed) Published
Abstract [en]

Objectives. To evaluate the additional information of second trimester magnetic resonance imaging (MRI) compared to ultrasound in fetuses with identified or suspected non-CNS anomalies and to study the clinical impact of the MRI information on pregnancy management. Design. Prospective study during 2003-2007. The fetal MRI examination was planned to be performed within three days after the ultrasound. Setting. Uppsala University hospital. Material and methods. Sixty-three women, where the second trimester ultrasound identified or raised suspicion of fetal anomalies were included. Ultrasound was compared to MRI in relation to the final diagnosis, which was based on the assessment of all available data including post-partum clinical follow-up and autopsy results. Main outcome measures. Evaluation of the additional information gained from MRI and the consequences it had on pregnancy management. Results. The mean interval between ultrasound and MRI was 2.6 days (range 0-15). In 42 (67%) cases MRI was performed within three days. All MRI examinations were assessable. In 43 (68%) fetuses MRI provided no additional information, in 17 (27%) MRI added information without changing the management and in three (5%) MRI provided additional information which changed the management. All these three cases had oligohydramnios. In all six cases of diaphragmatic hernia MRI provided additional information. Conclusions. Fetal MRI of non-CNS anomalies in the second trimester seems to be a valuable adjunct to ultrasound diagnosis of non-CNS anomalies, especially in cases of oligohydramnios and diaphragmatic hernia.

Keywords
Fetal magnetic resonance imaging, non-central nervous system anomalies, second trimester, ultrasound, pregnancy management, antenatal diagnosis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-146549 (URN)10.1111/j.1600-0412.2011.01071.x (DOI)000289515500014 ()21306331 (PubMedID)
Available from: 2011-02-17 Created: 2011-02-17 Last updated: 2017-12-11Bibliographically approved
Amini, H. (2010). Fetal Anomalies: Surveillance and Diagnostic Accuracy of Ultrasound and Magnetic Resonance Imaging. (Doctoral dissertation). Uppsala: Acta Universitatis Upsaliensis
Open this publication in new window or tab >>Fetal Anomalies: Surveillance and Diagnostic Accuracy of Ultrasound and Magnetic Resonance Imaging
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aims were to investigate the accuracy of ultrasound in diagnosis of structural fetal anomalies with special focus on false positive findings (I), to evaluate the additional value of second trimester fetal MRI on pregnancy management (II-III) and to estimate the ascertainment in the Swedish Birth Defects Registry and incidence of spina bifida and cleft lip/palate (IV).

Retrospectively, 328 fetal autopsies were identified where pregnancies were terminated due to ultrasonographically diagnosed fetal anomalies. In 175 (53.4 %) cases ultrasound and fetal autopsy were identical, in 124 (37.8 %) ultrasound was almost correct, in 23 (7.0 %)  ultrasound diagnoses could not be verified, but fetal autopsy showed other anomalies with at least the same prognostic value and in six (1.8 %)  ultrasound diagnosis could not be verified and autopsy showed no or less severe anomalies (I).

Prospectively, 29 pregnancies with CNS- (II) and 63 with non-CNS-anomalies (III) were included. In the CNS study MRI provided no additional information in 18 fetuses (62 %), additional information without changing the management in 8 (28 %) and additional information altering the pregnancy management in 3 (10%). In the non-CNS study the corresponding figures were 43 (68 %), 17 (27 %) and three (5 %), respectively. MRI in the second trimester might be a clinically valuable adjunct to ultrasound for the evaluation of CNS anomalies, especially when the ultrasound is inconclusive due to maternal obesity (II) and in non-CNS anomalies in cases of diaphragmatic hernia or oligohydramnios (III).

In newborns, the ascertainments of birth defects are relatively high and assessable, but in pregnancy terminations they are lower or unknown. The incidence of newborns with spina bifida has decreased because of an increased rate of pregnancy terminations (>60%). There is room for improvement concerning the reporting of anomalies from terminated pregnancies (IV).

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. p. 64
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 545
Keywords
Pregnancy termination, fetal anomalies, antenatal diagnosis, ultrasound, second trimester, fetal MRI, CNS anomalies, pregnancy management, non-CNS anomalies, fetal autopsy, birth defects registry, ascertainment, spina bifida, cleft lip/palate
National Category
Obstetrics, Gynecology and Reproductive Medicine Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:uu:diva-121503 (URN)978-91-554-7763-9 (ISBN)
Public defence
2010-05-07, Rudbeck auditorium, Rudbeck Laboratory, entrance C11, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Available from: 2010-04-16 Created: 2010-03-24 Last updated: 2010-04-16
Amini, H., Axelsson, O., Raiend, M. & Wikström, J. (2010). The Clinical Impact of Fetal Magnetic Resonance Imaging on Management of CNS Anomalies in the Second Trimester of Pregnancy. Acta Obstetricia et Gynecologica Scandinavica, 89(12), 1571-1581
Open this publication in new window or tab >>The Clinical Impact of Fetal Magnetic Resonance Imaging on Management of CNS Anomalies in the Second Trimester of Pregnancy
2010 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 89, no 12, p. 20p. 1571-1581Article in journal (Refereed) Published
Abstract [en]

Objectives: To evaluate the additional information of second trimester magnetic resonance imaging (MRI) compared to ultrasound in fetuses with identified or suspected CNS anomalies and to study the clinical impact of the information on pregnancy management.

Design: Prospective study during 2004-2007. The fetal MRI examination was planned to be performed within three days after the ultrasound.

Setting: Uppsala University hospital.    

Subjects: Twenty-nine pregnant women where second trimester ultrasound identified or suspected fetal CNS anomalies.

Main outcome measures: Evaluation of the additional information gained from MRI and the consequence it had on pregnancy management.

Results: The mean interval between ultrasound and MRI was 1.6 days (range 0 –7). In 18 fetuses (62 %)  MRI verified the ultrasound diagnosis but provided no additional information, while in 8 (28 %) MRI gave additional information without changing the management. In 3 (10 %), MRI provided additional information that changed the management of the pregnancy. Two of these women were obese.

Conclusions: Fetal MRI in the second trimester might be a clinically valuable adjunct to ultrasound for the evaluation of CNS anomalies, especially when ultrasound is inconclusive due to maternal obesity.

 

Publisher
p. 20
Keywords
CNS anomalies, Fetal MRI, Pregnancy management, Second trimester, Ultrasound
National Category
Medical and Health Sciences
Research subject
Obstetrics and Gynaecology; Medicine
Identifiers
urn:nbn:se:uu:diva-121487 (URN)10.3109/00016349.2010.526184 (DOI)000284318900012 ()21080900 (PubMedID)
Available from: 2010-03-24 Created: 2010-03-24 Last updated: 2017-12-12Bibliographically approved
Amini, H., Antonsson, P., Papadogiannakis, N., Ericson, K., Pilo, C., Eriksson, L., . . . Axelsson, O. (2006). Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies. Acta Obstetricia et Gynecologica Scandinavica, 85(10), 1208-1216
Open this publication in new window or tab >>Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies
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2006 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 85, no 10, p. 1208-1216Article in journal (Refereed) Published
Abstract [en]

Objective. To compare antenatal diagnoses with autopsy findings in pregnancies terminated after ultrasound detection of fetal anomalies. A second aim was to study the quality of antenatal fetal diagnosis over time. Design. Retrospective, multicenter study over two consecutive six-year periods in Uppsala and Stockholm. Setting. Cases were identified through fetal autopsy reports. Subjects. Three hundred and twenty-eight fetuses from pregnancies terminated between 1992 and 2003 because of ultrasonographically diagnosed anomalies. Main outcome measures. The findings at the last ultrasound examination were compared with the autopsy reports. Results. In 299 cases (91.2%) ultrasound findings either exactly matched or were essentially similar to the autopsy findings. In 23 cases (7%) ultrasound findings were not confirmed at autopsy, but the postnatal findings were at least as severe as the antenatal ones. In six cases (1.8%) termination was performed for an anomaly which proved to be less severe than was predicted by ultrasound. The number of such cases was the same in both six-year periods, while the total number of cases increased from 113 in the first to 215 in the second period. Fetal examination provided further diagnostic information in 47% of the cases. In 10% a syndrome was disclosed. Conclusion. Termination of pregnancy was not always based on a correct antenatal diagnosis. All fetuses but one from terminated pregnancies had evident anomalies. In six cases (1.8%) the decision to terminate was based on suboptimal prognostic and diagnostic information. Fetal autopsy by an experienced perinatal pathologist is essential to provide a definitive diagnosis.

Keywords
fetal anomaly, ultrasound, antenatal diagnosis, pregnancy termination, fetal autopsy
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-21374 (URN)10.1080/00016340600880886 (DOI)000241362200009 ()17068680 (PubMedID)
Available from: 2008-06-28 Created: 2008-06-28 Last updated: 2017-12-08Bibliographically approved
Hallberg, P., Hallberg, E. & Amini, H. (2004). Acute pancreatitis following medical abortion: Case report. BMC Women's Health, 4(1), 1
Open this publication in new window or tab >>Acute pancreatitis following medical abortion: Case report
2004 (English)In: BMC Women's Health, ISSN 1472-6874, E-ISSN 1472-6874, Vol. 4, no 1, p. 1-Article in journal (Other academic) Published
Abstract [en]

BACKGROUND: Acute pancreatitis rarely complicates pregnancy. Although most pregnant women with acute pancreatitis have associated gallstones, less common causes such as drugs have been reported. CASE PRESENTATION: We report the case of a 34-year-old woman who underwent medical abortion with mifepristone and gemeprost and received codeine as pain-relief during the induction of abortion. She developed a severe acute necrotizing pancreatitis which required 14 days of intensive care. Other possible etiological factors, i.e. gallstone, alcohol intake and hyperlipidemia, were excluded. CONCLUSIONS: The reported case of acute pancreatitis was most likely drug-induced.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-75704 (URN)10.1186/1472-6874-4-1 (DOI)15068485 (PubMedID)
Available from: 2007-04-23 Created: 2007-04-23 Last updated: 2017-12-14Bibliographically approved
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