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2020 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 276, article id 103413Article in journal (Refereed) Published
Abstract [en]
BACKGROUND: The aim of the present study was to investigate pulmonary stretch receptor activity (PSR) under different peak inspiratory pressures (PIPs) and inspiratory pressure waveforms during partial liquid (PLV) and gas ventilation (GV).
METHODS: PSR instantaneous impulse frequency (PSRfimp) was recorded from single fibers in the vagal nerve during PLV and GV in young cats. PIPs were set at 1.2/1.8/2.2/2.7 kPa, and square and sinusoidal pressure waveforms were applied.
RESULTS: PSRfimp at the start of inspiration increased with increasing PIPs, and was steeper and higher with square than with sinusoidal waveforms (p < 0.05). Total number of impulses, peak and mean PSRfimp were lower during PLV than GV at the lowest and highest PIPs (p < 0.025). Time to peak PSRfimp was shorter with square than with sinusoidal waveforms at all pressures and ventilations (p < 0.005). Irrespective of waveform, lower PIPs yielded lower ventilation during PLV.
CONCLUSION: As assessed by PSRfimp, increased PIPs do not expose the lungs to more stretching during PLV than during GV, with only minor differences between square and sinusoidal waveforms.
Keywords
Control of breathing, Partial liquid ventilation, Pressure controlled ventilation, Slowly adapting pulmonary stretch receptor
National Category
Physiology and Anatomy
Identifiers
urn:nbn:se:uu:diva-404678 (URN)10.1016/j.resp.2020.103413 (DOI)000527945900001 ()32044447 (PubMedID)
Funder
Swedish Research Council, K200373VX-14729-0IASwedish Research Council, K2002-72X-04998-26B
2020-02-252020-02-252025-02-10Bibliographically approved