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Jonzon, Anders
Alternative names
Publications (10 of 25) Show all publications
Stålhammar, M., Håkansson, L. D., Jonzon, A. & Sindelar, R. (2017). Differential Neutrophil Chemotactic Response towards IL-8 and Bacterial N-formyl Peptides in Term Newborn Infants. Upsala Journal of Medical Sciences, 122(1), 35-42
Open this publication in new window or tab >>Differential Neutrophil Chemotactic Response towards IL-8 and Bacterial N-formyl Peptides in Term Newborn Infants
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 1, p. 35-42Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A prerequisite for an effective innate immunity is the migrative ability of neutrophils to respond to inflammatory and infectious agents such as the intermediate interleukin (IL)-8 and the end-target formyl-methionyl-leucyl-phenylalanine (fMLP) chemoattractants. The aim was to study the chemotactic capacity of neutrophils from newborn infants and adults in response to IL-8 and the bacterial peptide fMLP.

METHODS: In the under-agarose cell migration assay, isolated leukocytes from healthy adults and from cord blood of healthy term newborn infants were studied with dose responses towards IL-8 and fMLP. The same number of leukocytes (1 × 10(5) cells), with the same distribution of neutrophils and monocytes, were analyzed in neonates and adults. Chemotaxis was distinguished from randomly migrating neutrophils, and the neutrophil pattern of migration, i.e. the migration distance and the number of migrating neutrophils per distance, was evaluated.

RESULTS: In comparison to adults, fewer neutrophils from newborn infants migrated towards IL-8 and for a shorter distance (P < .01, respectively). The number of neutrophils migrating to different gradients of fMLP, the distance they migrated, and the correlation between the number and the distance were the same for neonates and adults. Random migration did not differ in any instance.

CONCLUSION: Chemotaxis of neutrophils from newborn infants was as co-ordinated as neutrophils from adults in response to fMLP, whereas the response to IL-8 was reduced. The differential response of neutrophils from neonates to intermediate and end-target chemoattractants could indicate a reduced infectious response.

Keywords
Chemotaxis, chemoattractants, fMLP, innate immunity, IL-8, neutrophils, newborn infants
National Category
Pediatrics Immunology in the medical area
Research subject
Immunology; Pediatrics
Identifiers
urn:nbn:se:uu:diva-304756 (URN)10.1080/03009734.2016.1228721 (DOI)000396476600005 ()27690722 (PubMedID)
Available from: 2016-10-10 Created: 2016-10-10 Last updated: 2018-01-14Bibliographically approved
Bland, R. D. & Jonzon, A. (2014). Gunnar Sedin Obituary. Acta Paediatrica, 103(8), 893-893
Open this publication in new window or tab >>Gunnar Sedin Obituary
2014 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, no 8, p. 893-893Article in journal (Refereed) Published
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-231485 (URN)10.1111/apa.12709 (DOI)000339986800017 ()
Available from: 2014-09-09 Created: 2014-09-08 Last updated: 2017-12-05Bibliographically approved
Chetaille, P., Preuss, C., Burkhard, S., Cote, J.-M., Houde, C., Castilloux, J., . . . Andelfinger, G. (2014). Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics, 46(11), 1245-1249
Open this publication in new window or tab >>Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
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2014 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, p. 1245-1249Article in journal (Refereed) Published
Abstract [en]

The pacemaking activity of specialized tissues in the heart and gut results in lifelong rhythmic contractions. Here we describe a new syndrome characterized by Chronic Atrial and Intestinal Dysrhythmia, termed CAID syndrome, in 16 French Canadians and 1 Swede. We show that a single shared homozygous founder mutation in SGOL1, a component of the cohesin complex, causes CAID syndrome. Cultured dermal fibroblasts from affected individuals showed accelerated cell cycle progression, a higher rate of senescence and enhanced activation of TGF-beta signaling. Karyotypes showed the typical railroad appearance of a centromeric cohesion defect. Tissues derived from affected individuals displayed pathological changes in both the enteric nervous system and smooth muscle. Morpholino-induced knockdown of sgol1 in zebrafish recapitulated the abnormalities seen in humans with CAID syndrome. Our findings identify CAID syndrome as a novel generalized dysrhythmia, suggesting a new role for SGOL1 and the cohesin complex in mediating the integrity of human cardiac and gut rhythm.

National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-238437 (URN)10.1038/ng.3113 (DOI)000344131900017 ()25282101 (PubMedID)
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2018-01-11Bibliographically approved
Ekvall, S., Sjörs, K., Jonzon, A., Vihinen, M., Annerén, G. & Bondeson, M.-L. (2014). Novel association of neurofibromatosis type 1-causing mutations in families with neurofibromatosis-Noonan syndrome. American Journal of Medical Genetics. Part A, 164(3), 579-587
Open this publication in new window or tab >>Novel association of neurofibromatosis type 1-causing mutations in families with neurofibromatosis-Noonan syndrome
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2014 (English)In: American Journal of Medical Genetics. Part A, ISSN 1552-4825, E-ISSN 1552-4833, Vol. 164, no 3, p. 579-587Article in journal (Refereed) Published
Abstract [en]

Neurofibromatosis-Noonan syndrome (NFNS) is a rare condition with clinical features of both neurofibromatosis type 1 (NF1) and Noonan syndrome (NS). All three syndromes belong to the RASopathies, which are caused by dysregulation of the RAS-MAPK pathway. The major gene involved in NFNS is NF1, but co-occurring NF1 and PTPN11 mutations in NFNS have been reported. Knowledge about possible involvement of additional RASopathy-associated genes in NFNS is, however, very limited. We present a comprehensive clinical and molecular analysis of eight affected individuals from three unrelated families displaying features of NF1 and NFNS. The genetic etiology of the clinical phenotypes was investigated by mutation analysis, including NF1, PTPN11, SOS1, KRAS, NRAS, BRAF, RAF1, SHOC2, SPRED1, MAP2K1, MAP2K2, and CBL. All three families harbored a heterozygous NF1 variant, where the first family had a missense variant, c.5425C>T;p.R1809C, the second family a recurrent 4bp-deletion, c.6789_6792delTTAC;p.Y2264Tfs*6, and the third family a splice-site variant, c.2991-1G>A, resulting in skipping of exon 18 and an in-frame deletion of 41 amino acids. These NF1 variants have all previously been reported in NF1 patients. Surprisingly, both c.6789_6792delTTAC and c.2991-1G>A are frequently associated with NF1, but association to NFNS has, to our knowledge, not previously been reported. Our results support the notion that NFNS represents a variant of NF1, genetically distinct from NS, and is caused by mutations in NF1, some of which also cause classical NF1. Due to phenotypic overlap between NFNS and NS, we propose screening for NF1 mutations in NS patients, preferentially when café-au-lait spots are present.

Keywords
NF1, neurofibromatosis type 1, neurofibromatosis-Noonan syndrome, mutation, RAS-MAPK pathway, RASopathies
National Category
Medical Genetics
Research subject
Clinical Genetics
Identifiers
urn:nbn:se:uu:diva-223939 (URN)10.1002/ajmg.a.36313 (DOI)000331978700002 ()
Funder
Swedish Research Council
Available from: 2014-04-28 Created: 2014-04-28 Last updated: 2018-01-11Bibliographically approved
Meisgen, S., Ostberg, T., Salomonsson, S., Ding, B., Eliasson, H., Mälarstig, A., . . . Wahren-Herlenius, M. (2014). The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence. Journal of Internal Medicine, 275(6), 640-651
Open this publication in new window or tab >>The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence
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2014 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 275, no 6, p. 640-651Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The main aim of this study was to identify foetal susceptibility genes on chromosome six for Ro/SSA autoantibody-mediated congenital heart block.

SUBJECTS AND DESIGN: Single nucleotide polymorphism (SNP) genotyping of individuals in the Swedish Congenital Heart Block (CHB) study population was performed. Low-resolution HLA-A, -Cw and -DRB1 allele typing was carried out in 86 families comprising 339 individuals (86 Ro/SSA autoantibody-positive mothers, 71 fathers, 87 CHB index cases, and 95 unaffected siblings).

RESULTS: A case-control comparison between index cases and population-based out-of-study controls (n=1710) revealed association of CHB with 15 SNPs in the 6p21.3 MHC locus at a chromosome-wide significance of p<2.59×10(-6) (OR 2.21-3.12). In a family-based analysis of association of SNP markers as well as distinct MHC class I and II alleles with CHB, HLA-DRB1*04 and HLA-Cw*05 variants were significantly more frequently transmitted to affected individuals (p<0.03 and p<0.05, respectively), while HLA-DRB1*13 and HLA-Cw*06 variants were significantly less often transmitted to affected children (p<0.04 and p<0.03). We further observed marked association of increased paternal (but not maternal) HLA-DRB1*04 transmission to affected offspring (p<0.02).

CONCLUSIONS: HLA-DRB1*04 and HLA-Cw*05 were identified as novel foetal HLA allele variants that confer susceptibility to CHB in response to Ro/SSA autoantibody exposure, while DRB1*13 and Cw*06 emerged as protective alleles. Additionally, we demonstrated a paternal contribution to foetal susceptibility to CHB for the first time.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-219521 (URN)10.1111/joim.12179 (DOI)000337787300011 ()24354957 (PubMedID)
Available from: 2014-03-03 Created: 2014-03-03 Last updated: 2017-12-05Bibliographically approved
Sindelar, R. & Jonzon, A. (2013). Diafragmal pacing och kongenital centralt hypoventilationssyndrom. In: Terapikompendium i pediatrik: (pp. 1-3). Uppsala: UAS
Open this publication in new window or tab >>Diafragmal pacing och kongenital centralt hypoventilationssyndrom
2013 (Swedish)In: Terapikompendium i pediatrik, Uppsala: UAS , 2013, p. 1-3Chapter in book (Other academic)
Place, publisher, year, edition, pages
Uppsala: UAS, 2013
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-240271 (URN)
Available from: 2015-01-06 Created: 2015-01-06 Last updated: 2015-01-06
Sindelar, R. & Jonzon, A. (2013). PDA hos underburna barn. In: Terapikompendium i pediatrik: (pp. 1-3). Uppsala: UAS
Open this publication in new window or tab >>PDA hos underburna barn
2013 (Swedish)In: Terapikompendium i pediatrik, Uppsala: UAS , 2013, p. 1-3Chapter in book (Other academic)
Place, publisher, year, edition, pages
Uppsala: UAS, 2013
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-240269 (URN)
Available from: 2015-01-06 Created: 2015-01-06 Last updated: 2015-01-06
Gorgen, S., Ostberg, T., Salomonsson, S., Ding, B., Eliasson, H., Malarstig, A., . . . Wahren-Herlenius, M. (2013). The HLA Locus Contains Novel Foetal Susceptibility Alleles For Congenital Heart Block with Significant Paternal Influence. Paper presented at 33rd European Workshop for Rheumatology Research (EWRR), FEB 28-MAR 02, 2013, Prague, CZECH REPUBLIC. Annals of the Rheumatic Diseases, 72(S1), A56-A56
Open this publication in new window or tab >>The HLA Locus Contains Novel Foetal Susceptibility Alleles For Congenital Heart Block with Significant Paternal Influence
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2013 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 72, no S1, p. A56-A56Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-199605 (URN)10.1136/annrheumdis-2013-203221.23 (DOI)000316808400142 ()
Conference
33rd European Workshop for Rheumatology Research (EWRR), FEB 28-MAR 02, 2013, Prague, CZECH REPUBLIC
Available from: 2013-05-08 Created: 2013-05-08 Last updated: 2017-12-06Bibliographically approved
Hamberg, A.-K., Friberg, L. E., Hanséus, K., Ekman-Joelsson, B.-M., Sunnegårdh, J., Jonzon, A., . . . Wadelius, M. (2013). Warfarin dose prediction in children using pharmacometric bridging: comparison with published pharmacogenetic dosing algorithms. European Journal of Clinical Pharmacology, 69(6), 1275-1283
Open this publication in new window or tab >>Warfarin dose prediction in children using pharmacometric bridging: comparison with published pharmacogenetic dosing algorithms
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2013 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 69, no 6, p. 1275-1283Article in journal (Refereed) Published
Abstract [en]

Purpose

Numerous studies have investigated causes of warfarin dose variability in adults whereas studies in children are limited both in numbers and size. Mechanism-based population modelling provides an opportunity to condense and propagate prior knowledge from one population to another. The main objectives with this study were to evaluate the predictive performance of a theoretically bridged adult warfarin model in children, and to compare accuracy in dose prediction relative to published warfarin algorithms for children.

Method

An adult population PK/PD-model for warfarin, with CYP2C9 and VKORC1 genotype, age and target INR as dose predictors, was bridged to children using allometric scaling methods. Its predictive properties were evaluated in an external dataset of children 0-18 years old, including comparison of dose prediction accuracy with three pharmacogenetics-based algorithms for children.

Results

Overall, the bridged model predicted INR response well in 64 warfarin treated Swedish children (median age 4.3 years), but with a tendency to over predict INR in children ≤ 2 years old. The bridged model predicted 20 of 49 children (41%) within ± 20% of actual maintenance dose (median age 7.2 years). In comparison the published dosing algorithms predicted 33-41% of the children within ± 20% of actual dose. Dose optimization with the bridged model based on up to three individual INR observations increased the proportion within ± 20% of actual dose to 70%.

Conclusion

A mechanism-based population model developed on adult data provides a promising first step towards more individualized warfarin therapy in children.

Keywords
PK/PD model, Population analysis, Warfarin, Dosing, Children, Genotype
National Category
Pediatrics
Research subject
Clinical Pharmacology
Identifiers
urn:nbn:se:uu:diva-197596 (URN)10.1007/s00228-012-1466-4 (DOI)000318865600008 ()
Funder
Swedish Heart Lung Foundation
Note

Correction in: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY  Volume: 69, Issue: 9, Pages: 1737-1737, DOI: 10.1007/s00228-013-1565-x

Available from: 2013-04-02 Created: 2013-03-29 Last updated: 2017-12-06Bibliographically approved
Olsson, K. W., Jonzon, A. & Sindelar, R. (2012). A High Ductal Flow Velocity is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22-27 Weeks Gestational Age. Critical Care Research and Practice, 715265
Open this publication in new window or tab >>A High Ductal Flow Velocity is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22-27 Weeks Gestational Age
2012 (English)In: Critical Care Research and Practice, ISSN 2090-1305, E-ISSN 2090-1313, p. 715265-Article in journal (Refereed) Published
Abstract [en]

Objective:

To identify factors affecting closure of patent ductus arteriosus (PDA) in newborn infants born at 22-27 weeks gestational age (GA) during pharmacological treatment with cyclooxygenase inhibitors.

Method:

Infants born at 22-27 weeks of GA between January 2006 and December 2009 who had been treated pharmacologically for PDA were identified retrospectively. Medical records were assessed for clinical, ventilatory and outcome parameters. Echocardiographic examinations during treatment were reviewed.

Results:

Fifty-six infants were included in the study. Overall success rate of ductal closure with pharmacological treatment was 52%. Infants whose PDA was successfully closed had a higher GA (25+4 weeks vs. 24+3 weeks; P=0.047), and a higher pre-treatment left to right maximal ductal flow velocity (1.6 m/s vs. 1.1 m/s; P=0.023). Correcting for GA, preeclampsia, antenatal steroids, and age at treatment start, a higher maximal ductal flow velocity was still associated with successful ductal closure (OR 3.04, p=0.049).

Conclusion:

Maximal ductal flow velocity was independently associated with success of PDA treatment.

Keywords
patent ductus arteriosus, preterm, cyclooxygenase inhibitors, echocardiography
National Category
Medical and Health Sciences Pediatrics
Identifiers
urn:nbn:se:uu:diva-187783 (URN)10.1155/2012/715265 (DOI)
Funder
Swedish Heart Lung Foundation, 20100033
Available from: 2012-12-10 Created: 2012-12-10 Last updated: 2017-12-07Bibliographically approved
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