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Jonzon, Anders
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Publications (10 of 33) Show all publications
Tsolakis, N., Sindelar, R., Markström, A., Nilsson, P. & Jonzon, A. (2022). Applying diaphragm pacing in previously tracheostomised children with congenital central hypoventilation syndrome is a safe tool [Letter to the editor]. Acta Paediatrica, 111(6), 1283-1284
Open this publication in new window or tab >>Applying diaphragm pacing in previously tracheostomised children with congenital central hypoventilation syndrome is a safe tool
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2022 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 111, no 6, p. 1283-1284Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2022
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-483067 (URN)10.1111/apa.16324 (DOI)000768030700001 ()35266201 (PubMedID)
Available from: 2022-09-08 Created: 2022-09-08 Last updated: 2023-07-01Bibliographically approved
Tsolakis, N., Sindelar, R., Markström, A., Nilsson, P. & Jonzon, A. (2022). Strategy of changing from tracheostomy and non‐invasive mechanical ventilation to diaphragm pacing in children with congenital central hypoventilation syndrome. Acta Paediatrica, 111(6), 1245-1247
Open this publication in new window or tab >>Strategy of changing from tracheostomy and non‐invasive mechanical ventilation to diaphragm pacing in children with congenital central hypoventilation syndrome
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2022 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 111, no 6, p. 1245-1247Article in journal (Refereed) Published
Abstract [en]

Congenital central hypoventilation syndrome (CCHS) is a rare disorder that affects central control of breathing and paediatric treatment varies worldwide. One approach is diaphragm pacing (DP), by phrenic nerve stimulation or direct diaphragm muscle stimulation, with or without a tracheostomy. In Sweden, non-invasive ventilation (NIV) has been the first-line ventilator support for patients with CCHS. However, disadvantages such as midface hypoplasia and unintentional leakage have required assessment over time. DP implants are provided at the National Reference Center for Diaphragm Pacing at Uppsala University Hospital, Sweden, at 3-4 years of age, when the upper airways have become more stable. Some international centres wait until children are older. Our aim was to evaluate switching patients with CCHS from mechanical ventilation, namely tracheostomy or NIV, to DP.

Place, publisher, year, edition, pages
John Wiley & SonsWiley, 2022
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:uu:diva-466174 (URN)10.1111/apa.16256 (DOI)000748684700001 ()35040186 (PubMedID)
Available from: 2022-01-25 Created: 2022-01-25 Last updated: 2024-01-15Bibliographically approved
Markasz, L., Savani, R., Jonzon, A. & Sindelar, R. (2021). CD44 and RHAMM expression patterns in the human developing lung. Pediatric Research, 89, 134-142
Open this publication in new window or tab >>CD44 and RHAMM expression patterns in the human developing lung
2021 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 89, p. 134-142Article in journal (Refereed) Published
Abstract [en]

Background: The hyaluronan (HA) receptors CD44 and RHAMM (CD168) are involved in cellular proliferation, differentiation, and motility. As previously investigated, HA and RHAMM expression in human neonatal lungs correlates to gestational age (GA) and air content.

Methods:  CD44 immunofluorescence was analyzed in postmortem lung samples from infants (n=93;22-41GA) by digital image analysis together with clinical data, including RHAMM expression, lung air and HA content by hierarchical clustering.

Results: Five groups were defined according to RHAMM/CD44 expression, GA, and postnatal age (PNA): extremely-to-very preterm (EVP;22-31GA; Groups 1-2), moderately preterm-to-term (MPT;31-41GA; Groups 3-4) and mixed preterm-to-term (27-40GA; Group 5). CD44 correlated linearly with RHAMM in MPT (r=0.600;p<0.004). In EVP, high CD44 and low RHAMM corresponded with high PNA and lung air content independently of HA and GA (Group 1 vs 2;p<0.05 respectively). In MPT, high and low CD44 corresponded with low and high RHAMM independently of GA, HA and lung air content (Group 3 vs 4;p<0.001). No correlation between CD44 and GA/PNA at death was observed.

Conclusions: A linear correlation between CD44 and RHAMM expression occurs during the late saccular phase of lung development at birth, whereas postnatal influences on CD44 and RHAMM expression in extremely-to-very preterm infants cannot be excluded. 

Place, publisher, year, edition, pages
Nature Publishing Group, 2021
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:uu:diva-406893 (URN)10.1038/s41390-020-0873-y (DOI)000530593100001 ()32311697 (PubMedID)
Funder
Gillbergska stiftelsen
Available from: 2020-03-16 Created: 2020-03-16 Last updated: 2021-08-23Bibliographically approved
Rieger-Fackeldey, E., Jonzon, A., Schulze, A., Sedin, G. & Sindelar, R. (2020). Pulmonary stretch receptor activity during partial liquid ventilation with different pressure waveforms. Respiratory Physiology & Neurobiology, 276, Article ID 103413.
Open this publication in new window or tab >>Pulmonary stretch receptor activity during partial liquid ventilation with different pressure waveforms
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2020 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 276, article id 103413Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The aim of the present study was to investigate pulmonary stretch receptor activity (PSR) under different peak inspiratory pressures (PIPs) and inspiratory pressure waveforms during partial liquid (PLV) and gas ventilation (GV).

METHODS: PSR instantaneous impulse frequency (PSRfimp) was recorded from single fibers in the vagal nerve during PLV and GV in young cats. PIPs were set at 1.2/1.8/2.2/2.7 kPa, and square and sinusoidal pressure waveforms were applied.

RESULTS: PSRfimp at the start of inspiration increased with increasing PIPs, and was steeper and higher with square than with sinusoidal waveforms (p < 0.05). Total number of impulses, peak and mean PSRfimp were lower during PLV than GV at the lowest and highest PIPs (p < 0.025). Time to peak PSRfimp was shorter with square than with sinusoidal waveforms at all pressures and ventilations (p < 0.005). Irrespective of waveform, lower PIPs yielded lower ventilation during PLV.

CONCLUSION: As assessed by PSRfimp, increased PIPs do not expose the lungs to more stretching during PLV than during GV, with only minor differences between square and sinusoidal waveforms.

Keywords
Control of breathing, Partial liquid ventilation, Pressure controlled ventilation, Slowly adapting pulmonary stretch receptor
National Category
Physiology and Anatomy
Identifiers
urn:nbn:se:uu:diva-404678 (URN)10.1016/j.resp.2020.103413 (DOI)000527945900001 ()32044447 (PubMedID)
Funder
Swedish Research Council, K200373VX-14729-0IASwedish Research Council, K2002-72X-04998-26B
Available from: 2020-02-25 Created: 2020-02-25 Last updated: 2025-02-10Bibliographically approved
Olsson, K. W., Jonzon, A. & Sindelar, R. (2019). Early haemodynamically significant patent ductus arteriosus does not predict future persistence in extremely preterm infants. Acta Paediatrica, 108(9), 1590-1956
Open this publication in new window or tab >>Early haemodynamically significant patent ductus arteriosus does not predict future persistence in extremely preterm infants
2019 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 108, no 9, p. 1590-1956Article in journal (Refereed) Published
Abstract [en]

Aim

We assessed whether early haemodynamically significant patent ductus arteriosus (hsPDA) predicted persistent patent ductus arteriosus (PDA) in extremely preterm infants.

Methods

This prospective observational study of 60 infants born at 22–27 weeks of gestational age (GA) without any major congenital anomalies or heart defects was conducted at Uppsala University Children's Hospital from November 2012 to May 2015. Respiratory and systemic circulatory parameters were continuously recorded, and echocardiographic examinations performed daily during the first three days of life. Pharmacological treatment was initiated if hsPDA was found on days two to seven. Persistent PDA was diagnosed if hsPDA remained after pharmacological treatment or pharmacological treatment was contraindicated.

Results

The infants (56% male) had a median GA of 25 + 2 weeks and 50% received pharmacological treatment. PDA was persistent in 30% and ultimately closed or insignificant in 70%. hsPDA on days two to seven was not associated with future persistent PDA (p = 1.000). Mechanical ventilation (p = 0.025), high mean airway pressure (p = 0.020) and low ductal maximal flow velocity (Vmax) (p = 0.024) on day two were associated with future persistent PDA.

Conclusion

Early hsPDA did not predict persistent PDA, but the early need for assisted ventilation and low ductal Vmax were associated with future persistent PDA in these extremely preterm infants.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
patent ductus arteriosus, echocardiography, ductal flow velocity, extremely preterm infant, haemodynamical significance
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:uu:diva-368852 (URN)10.1111/apa.14752 (DOI)000479320100008 ()30748032 (PubMedID)
Available from: 2018-12-08 Created: 2018-12-08 Last updated: 2019-09-30Bibliographically approved
Olsson, K. W., Larsson, A., Jonzon, A. & Sindelar, R. (2019). Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation. Pediatric Research, 86, 333-338
Open this publication in new window or tab >>Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation
2019 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 86, p. 333-338Article in journal (Refereed) Published
Abstract [en]

Background

Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA, in extremely preterm infants.

Methods

Infants born at 22–27 weeks’ gestation were included in this prospective study. Blood samples were collected on the second day of life. Fourteen biochemical markers associated with factors that may affect PDA closure were analyzed and related to persistent PDA and to the response of pharmacological treatment with ibuprofen.

Results

High levels of B-type natriuretic peptide, interleukin-6, -8, -10, and -12, growth differentiation factor 15 and monocyte chemotactic protein 1 were associated with persistent PDA, as were low levels of platelet-derived growth factor. High levels of erythropoietin were associated with both persistent PDA and failure to close PDA within 24 h of the last dose of ibuprofen.

Conclusions

High levels of inflammatory markers were associated with the persistence of PDA. High levels of erythropoietin were associated with both the persistence of PDA and failure to respond to pharmacological treatment.

National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:uu:diva-363383 (URN)10.1038/s41390-018-0182-x (DOI)000481648100010 ()30287890 (PubMedID)
Available from: 2018-10-18 Created: 2018-10-18 Last updated: 2019-10-04Bibliographically approved
Olsson, K. W., Larsson, A., Jonzon, A. & Sindelar, R. (2019). Insights image for exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation: [published in Pediatric Research volume 86, page 413 (2019)]. , 86
Open this publication in new window or tab >>Insights image for exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation: [published in Pediatric Research volume 86, page 413 (2019)]
2019 (English)Other (Refereed)
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-388598 (URN)10.1038/s41390-019-0458-9 (DOI)000481648100023 ()31195403 (PubMedID)
Note

Image supplement to Olsson, K. W., Larsson, A., Jonzon, A., Sindelar R. Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation. Pediatr Res. (2018). https://doi.org/10.1038/s41390-018-0182-x

Available from: 2019-07-02 Created: 2019-07-02 Last updated: 2019-10-04Bibliographically approved
Stålhammar, M., Håkansson, L. D., Jonzon, A. & Sindelar, R. (2017). Differential Neutrophil Chemotactic Response towards IL-8 and Bacterial N-formyl Peptides in Term Newborn Infants. Upsala Journal of Medical Sciences, 122(1), 35-42
Open this publication in new window or tab >>Differential Neutrophil Chemotactic Response towards IL-8 and Bacterial N-formyl Peptides in Term Newborn Infants
2017 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 1, p. 35-42Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A prerequisite for an effective innate immunity is the migrative ability of neutrophils to respond to inflammatory and infectious agents such as the intermediate interleukin (IL)-8 and the end-target formyl-methionyl-leucyl-phenylalanine (fMLP) chemoattractants. The aim was to study the chemotactic capacity of neutrophils from newborn infants and adults in response to IL-8 and the bacterial peptide fMLP.

METHODS: In the under-agarose cell migration assay, isolated leukocytes from healthy adults and from cord blood of healthy term newborn infants were studied with dose responses towards IL-8 and fMLP. The same number of leukocytes (1 × 10(5) cells), with the same distribution of neutrophils and monocytes, were analyzed in neonates and adults. Chemotaxis was distinguished from randomly migrating neutrophils, and the neutrophil pattern of migration, i.e. the migration distance and the number of migrating neutrophils per distance, was evaluated.

RESULTS: In comparison to adults, fewer neutrophils from newborn infants migrated towards IL-8 and for a shorter distance (P < .01, respectively). The number of neutrophils migrating to different gradients of fMLP, the distance they migrated, and the correlation between the number and the distance were the same for neonates and adults. Random migration did not differ in any instance.

CONCLUSION: Chemotaxis of neutrophils from newborn infants was as co-ordinated as neutrophils from adults in response to fMLP, whereas the response to IL-8 was reduced. The differential response of neutrophils from neonates to intermediate and end-target chemoattractants could indicate a reduced infectious response.

Keywords
Chemotaxis, chemoattractants, fMLP, innate immunity, IL-8, neutrophils, newborn infants
National Category
Pediatrics Immunology in the medical area
Research subject
Immunology; Pediatrics
Identifiers
urn:nbn:se:uu:diva-304756 (URN)10.1080/03009734.2016.1228721 (DOI)000396476600005 ()27690722 (PubMedID)
Available from: 2016-10-10 Created: 2016-10-10 Last updated: 2018-01-14Bibliographically approved
Bland, R. D. & Jonzon, A. (2014). Gunnar Sedin. Acta Paediatrica, 103(8), 893-893
Open this publication in new window or tab >>Gunnar Sedin
2014 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, no 8, p. 893-893Article in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2014
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-231485 (URN)10.1111/apa.12709 (DOI)000339986800017 ()25066763 (PubMedID)
Note

Biographical item

Available from: 2014-09-09 Created: 2014-09-08 Last updated: 2024-04-12Bibliographically approved
Chetaille, P., Preuss, C., Burkhard, S., Cote, J.-M., Houde, C., Castilloux, J., . . . Andelfinger, G. (2014). Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics, 46(11), 1245-1249
Open this publication in new window or tab >>Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
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2014 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, p. 1245-1249Article in journal (Refereed) Published
Abstract [en]

The pacemaking activity of specialized tissues in the heart and gut results in lifelong rhythmic contractions. Here we describe a new syndrome characterized by Chronic Atrial and Intestinal Dysrhythmia, termed CAID syndrome, in 16 French Canadians and 1 Swede. We show that a single shared homozygous founder mutation in SGOL1, a component of the cohesin complex, causes CAID syndrome. Cultured dermal fibroblasts from affected individuals showed accelerated cell cycle progression, a higher rate of senescence and enhanced activation of TGF-beta signaling. Karyotypes showed the typical railroad appearance of a centromeric cohesion defect. Tissues derived from affected individuals displayed pathological changes in both the enteric nervous system and smooth muscle. Morpholino-induced knockdown of sgol1 in zebrafish recapitulated the abnormalities seen in humans with CAID syndrome. Our findings identify CAID syndrome as a novel generalized dysrhythmia, suggesting a new role for SGOL1 and the cohesin complex in mediating the integrity of human cardiac and gut rhythm.

National Category
Medical Genetics and Genomics
Identifiers
urn:nbn:se:uu:diva-238437 (URN)10.1038/ng.3113 (DOI)000344131900017 ()25282101 (PubMedID)
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2025-02-10Bibliographically approved
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