uu.seUppsala University Publications
Change search
Link to record
Permanent link

Direct link
BETA
Alternative names
Publications (10 of 99) Show all publications
Janson, O., Sörensen, J. H., Strömme, M., Engqvist, H., Procter, P. & Welch, K. (2019). Evaluation of an alkali-treated and hydroxyapatite-coated orthopedic implant loaded with tobramycin. Journal of biomaterials applications
Open this publication in new window or tab >>Evaluation of an alkali-treated and hydroxyapatite-coated orthopedic implant loaded with tobramycin
Show others...
2019 (English)In: Journal of biomaterials applications, ISSN 0885-3282, E-ISSN 1530-8022Article in journal (Refereed) Published
Abstract [en]

An approximately 1-µm thick hydroxyapatite coating was biomimetically deposited on an alkali-treated, commercially available orthopedic screw surface (type II anodized titanium). Tobramycin loaded into the coating via a simple soaking method was shown to provide a sustained release above the minimal inhibitory concentration 0.2 µg/µl for up to two days. Agar diffusion tests showed that the tobramycin-loaded coating was able to produce a zone of inhibition against Staphylococcus aureus for up to five days. Biocompatibility testing using outgrowth endothelial cells and primary osteoblasts suggested that good cell compatibility of the coating can be expected in vivo. A rabbit distal femur condyle model was used for in vivo evaluation of the antibacterial efficacy of the tobramycin-loaded coating, and this pilot study showed that the release of tobramycin was sufficient to locally eliminate very large amounts of bacteria in vivo (inoculation dose 104–105 CFU S. aureus/test site).

Place, publisher, year, edition, pages
SAGE Publications Ltd STM, 2019
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
Identifiers
urn:nbn:se:uu:diva-390827 (URN)10.1177/0885328219867968 (DOI)
Available from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-08-14
Yang, J., Han, Y., Luo, J., Liefer, K., Strömme, M. & Welch, K. (2019). Synthesis and Characterization of Amorphous Magnesium Carbonate Nanoparticles. Materials Chemistry and Physics, 224, 301-307
Open this publication in new window or tab >>Synthesis and Characterization of Amorphous Magnesium Carbonate Nanoparticles
Show others...
2019 (English)In: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 224, p. 301-307Article in journal (Refereed) Published
Abstract [en]

We report the template-free, low-temperature, environment-friendly synthesis of amorphous magnesium carbonate nanoparticles (AMN). Scanning electron microscopy and transmission electron microscopy show that AMN consist of small nanoparticles approximately 20-65 nm in diameter. Drying temperature and centrifugation are shown to affect the nanostructure and functional properties of the material. Aggregated AMN can be produced with a total pore volume up to 1.72 cm(3)/g and can absorb as much as 24 mmol/g water, substantially surpassing the pore volume and moisture-absorbing capacity of all previously described alkali earth metal carbonates. The nanoparticles are foreseen to be useful in applications such as water sorption, drug delivery and catalysis.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Nanoparticle, Amorphous, Magnesium carbonate, Water sorption
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-354505 (URN)10.1016/j.matchemphys.2018.12.037 (DOI)000456750900036 ()
Funder
VINNOVA
Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2019-04-24Bibliographically approved
Hulsart Billström, G., Janson, O., Engqvist, H., Welch, K. & Hong, J. (2019). Thromboinflammation as bioactivity assessment of H2O2-alkali modified titanium surfaces. Journal of materials science. Materials in medicine, 30(6), Article ID 66.
Open this publication in new window or tab >>Thromboinflammation as bioactivity assessment of H2O2-alkali modified titanium surfaces
Show others...
2019 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 30, no 6, article id 66Article in journal (Refereed) Published
Abstract [en]

The release of growth factors from platelets, mediated by the coagulation and the complement system, plays an important role in the bone formation around implants. This study aimed at exploring the thromboinflammatory response of H2O2-alkali soaked commercially pure titanium grade 2 discs exposed to whole human blood, as a way to assess the bioactivity of the discs. Commercially pure titanium grade 2 discs were modified by soaking in H2O2, NaOH and Ca(OH)2. The platelet aggregation, coagulation activation and complement activation was assessed by exposing the discs to fresh whole blood from human donors. The platelet aggregation was examined by a cell counter and the coagulation and complement activation were assessed by ELISA-measurements of the concentration of thrombin-antithrombin complex, C3a and terminal complement complex. The modified surface showed a statistically significant increased platelet aggregation, coagulation activation and complement activation compared to unexposed blood. The surface also showed a statistically significant increase of coagulation activation compared to PVC. The results of this study showed that the H2O2-alkali soaked surfaces induced a thromboinflammatory response that indicates that the surfaces are bioactive.

National Category
Other Materials Engineering Biomaterials Science
Identifiers
urn:nbn:se:uu:diva-358034 (URN)10.1007/s10856-019-6248-4 (DOI)000468976700001 ()31127371 (PubMedID)
Funder
Swedish Research Council, 2016-2075-5.1; 2016-04519Vinnova
Available from: 2018-08-23 Created: 2018-08-23 Last updated: 2019-06-25Bibliographically approved
Janson, O., Gururaj, S., Pujari-Palmer, S., Karlsson Ott, M., Strømme, M., Engqvist, H. & Welch, K. (2019). Titanium surface modification to enhance antibacterial and bioactive properties while retaining biocompatibility. Materials science & engineering. C, biomimetic materials, sensors and systems, 96, 272-279
Open this publication in new window or tab >>Titanium surface modification to enhance antibacterial and bioactive properties while retaining biocompatibility
Show others...
2019 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 96, p. 272-279Article in journal (Refereed) Published
Abstract [en]

Bacterial infections associated with metal implants are severe problems affecting a considerable amount of people with dental or orthopedic implants. This study aims to examine the antibacterial effect of a Titanium-peroxy gel layer on the modified surface of commercially pure titanium grade 2. Variations in a multi-step surface modification procedure were tested to determine the best combination that provided an antibacterial effect while enhancing bioactivity without compromising biocompatibility. Soaking the surfaces in 30 wt% hydrogen peroxide held at 80 °C provided antibacterial activity while subsequent surface treatments in concentrated sodium and calcium hydroxide solutions were preformed to enhance bioactivity. Staphylococcus epidermidis was used to determine the antibacterial effect through both direct contact and biofilm inhibition tests while human dermal fibroblast cells and MC3T3 pre osteoblast cells were utilized to test biocompatibility. The greatest antibacterial effect was observed with only hydrogen peroxide treatment, but the resulting surface was neither bioactive nor biocompatible. It was found that subsequent surface treatments with sodium hydroxide followed by calcium hydroxide provided a bioactive surface that was also biocompatible. Additionally, a final treatment with autoclaving showed positive effects with regards to enhanced bioactivity. This multi-step surface modification procedure offers a promising, non-antibiotic, solution for combatting infections associated with biomedical implants.

Keywords
Titanium, Antibacterial, Bioactivity, Cell viability, Sodium titanate, Calcium titanate
National Category
Materials Engineering
Identifiers
urn:nbn:se:uu:diva-358023 (URN)10.1016/j.msec.2018.11.021 (DOI)000456760700027 ()30606532 (PubMedID)
Funder
Vinnova
Available from: 2018-08-23 Created: 2018-08-23 Last updated: 2019-03-15Bibliographically approved
Pochard, I., Vall, M., Eriksson, J., Farineau, C., Cheung, O., Frykstrand, S., . . . Strömme, M. (2018). Amine-functionalised mesoporous magnesium carbonate: Dielectric spectroscopy studies of interactions with water and stability. Materials Chemistry and Physics, 216, 332-338
Open this publication in new window or tab >>Amine-functionalised mesoporous magnesium carbonate: Dielectric spectroscopy studies of interactions with water and stability
Show others...
2018 (English)In: Materials Chemistry and Physics, ISSN 0254-0584, E-ISSN 1879-3312, Vol. 216, p. 332-338Article in journal (Refereed) Published
Abstract [en]

A mesoporous magnesium carbonate (MMC) material that was first described in 2013 is currently being investigated for several industrial and life-science-based applications. In this paper, the effect of functionalising the surface of MMC with amine groups on the water interaction properties of the material is investigated in detail. Amine functionalisation enhanced the stability and water sorption-release properties of the material. This is explained by the low affinity between amine-functionalised MMC and water molecules, as attested by the high free/total water ratio shown by dielectric spectroscopy. This low affinity had an impact on the total amount of adsorbed water at low relative humidities (RHs) but not at high RHs. The functionalisation of MMC with amine groups also stabilised the material in moist environments, hindering spontaneous crystallisation. These results provide a more fundamental understanding of the water interaction properties of MMC and are also expected to facilitate optimisation of the stability of materials like this for novel drug formulations and other life-science applications, as well as for their use in humidity control.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2018
Keywords
Magnesium carbonate, Mesoporous, Amine functionalisation, Moisture, Dielectric spectroscopy
National Category
Materials Chemistry Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-362476 (URN)10.1016/j.matchemphys.2018.05.053 (DOI)000441492000044 ()
Funder
Swedish Research Council, 2014-3929
Available from: 2018-10-05 Created: 2018-10-05 Last updated: 2019-03-25Bibliographically approved
Yang, J., Alvebratt, C., Lu, X., Bergström, C., Strömme, M. & Welch, K. (2018). Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen. International Journal of Pharmaceutics, 548(1), 515-521
Open this publication in new window or tab >>Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen
Show others...
2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 548, no 1, p. 515-521Article in journal (Refereed) Published
Abstract [en]

Formulating active pharmaceutical ingredients (APIs) in the amorphous state can increase their apparent aqueous solubility and dissolution rate and consequently improve their bioavailability. This study demonstrates, for the first time, the ability to stabilize an API in the amorphous state using a solid dispersion of magnesium carbonate nanoparticles within the API. Specifically, high proportions of ibuprofen were able to be stabilized in the amorphous state using as little as 17% wt/wt amorphous magnesium carbonate nanoparticles, and drug release rates 83 times faster than from the crystalline state were achieved. Biocompatibility of the nanoparticles was demonstrated in vitro using human dermal fibroblasts and stability of the nanocomposite formulation was verified with a storage time of six months. The success of this novel formulation provides a promising approach for achieving improved apparent solubility and enhanced bioavailability of drugs.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Magnesium carbonate, Nanoparticles, Nanocomposite, Amorphous, Ibuprofen, Solubility, Dissolution
National Category
Nano Technology Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-354506 (URN)10.1016/j.ijpharm.2018.07.021 (DOI)000440552100050 ()29981897 (PubMedID)
Funder
Swedish Research Council
Available from: 2018-06-20 Created: 2018-06-20 Last updated: 2018-11-12Bibliographically approved
Yang, J. & Welch, K. (2018). Amorphous magnesium carbonate nanoparticles with ultrahigh stabilizing capability for amorphous ibuprofen. In: 3rd international conference on materials science and nanotechnology: . Paper presented at 3rd international conference on materials science and nanotechnology, Mar 29- Apr 1, 2018, Chengdu, China.
Open this publication in new window or tab >>Amorphous magnesium carbonate nanoparticles with ultrahigh stabilizing capability for amorphous ibuprofen
2018 (English)In: 3rd international conference on materials science and nanotechnology, 2018Conference paper, Published paper (Refereed)
National Category
Other Materials Engineering Medical Materials
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-365150 (URN)
Conference
3rd international conference on materials science and nanotechnology, Mar 29- Apr 1, 2018, Chengdu, China
Available from: 2018-11-09 Created: 2018-11-09 Last updated: 2019-03-06Bibliographically approved
Janson, O., Strømme, M., Engqvist, H. & Welch, K. (2018). Debridement of Bacterial Biofilms with TiO2/H2O2 Solutions and Visible Light Irradiation. International Journal of Biomaterials, 2018, Article ID 5361632.
Open this publication in new window or tab >>Debridement of Bacterial Biofilms with TiO2/H2O2 Solutions and Visible Light Irradiation
2018 (English)In: International Journal of Biomaterials, ISSN 1687-8787, E-ISSN 1687-8795, Vol. 2018, article id 5361632Article in journal (Refereed) Published
Abstract [en]

Objectives. The aim of the study was to explore the debridement efficacy of different solutions of H2O2 and rutile particles against Staphylococcus epidermidis and Pseudomonas aeruginosa biofilms attached to titanium surfaces when exposed to visible light. Materials and Methods. Titanium discs cultivated with biofilms of Staphylococcus epidermidis or Pseudomonas aeruginosa were subjected for 1 min to suspensions consisting of rutile particles mixed with high (950 mM) or low (2 mM) concentrations of H2O2 under visible light irradiation (405 nm; 2.1 mW/cm2). Discs were rinsed and the degree of debridement was determined through scanning electron microscopy and viability assessment of the remaining bacteria using luminescence measurements and/or a metabolic activity assay. Results. Cleaning mixtures containing the higher concentration of H2O2 showed a significantly improved debridement compared to the negative control in all experiments. The addition of rutile particles was shown to have a statistically significant effect in one test with S. epidermidis. Limited evidence of the catalytic effect of visible light irradiation was seen, but effects were relatively small and statistically insignificant. Conclusions. H2O2 at a concentration of 950 mM proved to be the strongest contribution to the debridement and bactericidal effect of the cleaning techniques tested in this study.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2018
National Category
Nano Technology Biomaterials Science
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
Identifiers
urn:nbn:se:uu:diva-355674 (URN)10.1155/2018/5361632 (DOI)000438846900001 ()30057613 (PubMedID)
Funder
VINNOVA, E!8320
Available from: 2018-07-03 Created: 2018-07-03 Last updated: 2018-09-26Bibliographically approved
Basu, A., Heitz, K., Strömme, M., Welch, K. & Ferraz, N. (2018). Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications. Carbohydrate Polymers, 181, 345-350
Open this publication in new window or tab >>Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications
Show others...
2018 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, p. 345-350Article in journal (Refereed) Published
Abstract [en]

Development of advanced dressings with antimicrobial properties for the treatment of infected wounds is an important approach in the fight against evolution of antibiotic resistant bacterial strains. Herein, the effects of ion-crosslinked nanocellulose hydrogels on bacteria commonly found in infected wounds were investigated in vitro. By using divalent calcium or copper ions as crosslinking agents, different antibacterial properties against the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa were obtained. Calcium crosslinked hydrogels were found to retard S. epidermidis growth (up to 266% increase in lag time, 36% increase in doubling time) and inhibited P. aeruginosa biofilm formation, while copper crosslinked hydrogels prevented S. epidermidis growth and were bacteriostatic towards P. aeruginosa (49% increase in lag time, 78% increase in doubling time). The wound dressing candidates furthermore displayed barrier properties towards both S. epidermidis and P. aeruginosa, hence making them interesting for further development of advanced wound dressings with tunable antibacterial properties.

Keywords
Nanofibrillated cellulose, Biofilm, Wound dressing, Infected wound
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-333382 (URN)10.1016/j.carbpol.2017.10.085 (DOI)000418661000041 ()29253982 (PubMedID)
Funder
Swedish Research Council Formas
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2018-10-12Bibliographically approved
Zhang, X., Welch, K., Tian, L., Johansson, M. B., Häggman, L., Liu, J. & Johansson, E. M. (2017). Enhanced charge carrier extraction by a highly ordered wrinkled MgZnO thin film for colloidal quantum dot solar cells. Journal of Materials Chemistry C, 5(42), 11111-11120
Open this publication in new window or tab >>Enhanced charge carrier extraction by a highly ordered wrinkled MgZnO thin film for colloidal quantum dot solar cells
Show others...
2017 (English)In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 5, no 42, p. 11111-11120Article in journal (Refereed) Published
Abstract [en]

Efficient charge carrier extraction from a colloidal quantum dot (CQD) solid is crucial for highperformance of CQD solar cells (CQDSCs). Herein, highly ordered wrinkled MgZnO (MZO) thin films aredemonstrated to improve the charge carrier extraction of PbS CQDSCs. The highly ordered wrinkledMZO thin films are prepared using a low-temperature combustion method. The photovoltaicperformances of CQDSCs with a combustion-processed MZO (CP-MZO) thin film as an electrontransport material (ETM) are compared to those of CQDSCs with a conventional sol–gel processed MZO(SGP-MZO) thin film as an ETM. We performed photoluminescence quenching measurements of thecolloidal quantum dot (CQD) solid and charge carrier dynamic analysis of full solar cell devices. Theresults show that the highly ordered wrinkled CP-MZO thin film significantly increases the chargecarrier extraction from the CQD solid and therefore diminishes the charge interfacial recombination atthe CQD/ETM junction, leading to a 15.5% increase in power conversion efficiency. The improvedefficiency in the CP-MZO based CQDSC is also attributed to the compact and pin-hole free CP-MZOthin film.

National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-337927 (URN)10.1039/C7TC02740K (DOI)000414359500026 ()
Funder
Swedish Research CouncilSwedish Research Council FormasSwedish Energy AgencyGöran Gustafsson Foundation for Research in Natural Sciences and MedicineÅForsk (Ångpanneföreningen's Foundation for Research and Development)
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-07Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4543-1130

Search in DiVA

Show all publications