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Courivaud, Frederic
Publications (2 of 2) Show all publications
Weis, J., Johansson, L., Courivaud, F., Karlsson, F. A. & Ahlström, H. (2007). Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution. Magnetic Resonance in Medicine, 57(1), 22-28
Open this publication in new window or tab >>Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution
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2007 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 57, no 1, p. 22-28Article in journal (Refereed) Published
Abstract [en]

Quantification of intramyocellular lipids (IMCL) in obese subjects by single-voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extramyocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high-resolution SI with 128 phase-encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle.

Keywords
Adult, Body Mass Index, Female, Humans, Image Enhancement, Leg, Lipids/*analysis, Magnetic Resonance Spectroscopy/*methods, Middle Aged, Muscle Fibers/*chemistry/metabolism, Muscle; Skeletal/*chemistry/metabolism, Obesity, Reference Values
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-17088 (URN)10.1002/mrm.21085 (DOI)000243538900004 ()17152088 (PubMedID)
Available from: 2008-06-16 Created: 2008-06-16 Last updated: 2017-12-08Bibliographically approved
Weis, J., Courivaud, F., Hansen, M. S., Johansson, L., Ribe, L. R. & Ahlström, H. (2005). Lipid content in the musculature of the lower leg: evaluation with high-resolution spectroscopic imaging. Magnetic Resonance in Medicine, 54(1), 152-158
Open this publication in new window or tab >>Lipid content in the musculature of the lower leg: evaluation with high-resolution spectroscopic imaging
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2005 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 54, no 1, p. 152-158Article in journal (Refereed) Published
Abstract [en]

A novel spectroscopic imaging method with high spectral and spatial resolution was developed for the specific goal of assessing muscle fat. Sensitivity to the methylene and methyl protons of fatty acids was improved by the use of a binomial 1 excitation pulse instead of the standard radiofrequency (RF) pulse. Acceptable measurement time is achieved by using a narrow spectral bandwidth (6 ppm). The spectral resolution is sufficient to resolve extramyocellular (EMCL) and intramyocellular (IMCL) lipids. A post-detection data processing scheme that permits correction of spectral artifacts caused by chemical shifts, spectral line aliasing, and magnetic field inhomogeneities is suggested. The lipid content in different lower leg muscles was evaluated. Muscle fiber orientation was taken into account in assessing quantities of EMCL and IMCL. The proposed technique allows small amounts of inhomogeneously distributed muscle lipids to be quantified.

Keywords
Adult, Algorithms, Body Constitution, Comparative Study, Female, Humans, Lipid Metabolism, Lipids/analysis, Lower Extremity/*physiology, Magnetic Resonance Spectroscopy/*methods, Male, Middle Aged, Muscle; Skeletal/*metabolism, Research Support; Non-U.S. Gov't, Signal Processing; Computer-Assisted
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-77871 (URN)10.1002/mrm.20518 (DOI)15968653 (PubMedID)
Available from: 2006-03-16 Created: 2006-03-16 Last updated: 2017-12-14Bibliographically approved
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