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Fischer, Celia
Publications (10 of 12) Show all publications
Fischer, C., Bergman, S., Fredriksson, A., Stenerlöw, B. & Eriksson, P. (2007). Developmental neurobehavioural effects after co-exposure to gamma-radiation and methyl mercury during a critical phase of neonatal brain development in mice. In: The Toxicologist.
Open this publication in new window or tab >>Developmental neurobehavioural effects after co-exposure to gamma-radiation and methyl mercury during a critical phase of neonatal brain development in mice
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2007 (English)In: The Toxicologist, 2007Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-13611 (URN)
Available from: 2008-05-15 Created: 2008-05-15
Fischer, C., Fredriksson, A. & Eriksson, P. (2006). Enhanced developmental neurobehavioural defects in mice neonatally co-exposed to an ortho-susbstituted PCB (PCB 153), co-planar PCB (PCB 126), or a brominated flame retardant (PBDE 99) in addition to methylmercury. In: The Toxicologist (pp. 1456).
Open this publication in new window or tab >>Enhanced developmental neurobehavioural defects in mice neonatally co-exposed to an ortho-susbstituted PCB (PCB 153), co-planar PCB (PCB 126), or a brominated flame retardant (PBDE 99) in addition to methylmercury
2006 (English)In: The Toxicologist, 2006, p. 1456-Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-23001 (URN)
Available from: 2007-01-24 Created: 2007-01-24
Eriksson, P., Fischer, C., Wallin, M., Jakobsson, E. & Fredriksson, A. (2006). Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD). Environmental Toxicology and Pharmacology, 21, 317-322
Open this publication in new window or tab >>Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD)
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2006 (English)In: Environmental Toxicology and Pharmacology, Vol. 21, p. 317-322Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-22884 (URN)
Available from: 2007-01-23 Created: 2007-01-23 Last updated: 2011-01-11
Fischer, C., Fredriksson, A. & Eriksson, P. (2006). PCBs (PCB 153) and PCB 126) and PBDE (PBDE 99) can interact with methylmercury in enhancing developmental neurotoxic effects. In: Organohalogen Compounds.
Open this publication in new window or tab >>PCBs (PCB 153) and PCB 126) and PBDE (PBDE 99) can interact with methylmercury in enhancing developmental neurotoxic effects
2006 (English)In: Organohalogen Compounds, 2006Conference paper, Published paper (Other scientific)
Identifiers
urn:nbn:se:uu:diva-22896 (URN)
Available from: 2007-01-23 Created: 2007-01-23
Eriksson, P., Fischer, C. & Fredriksson, A. (2006). Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects. Toxicological Sciences, 94(2), 302-309
Open this publication in new window or tab >>Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects
2006 (English)In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 94, no 2, p. 302-309Article in journal (Refereed) Published
Abstract [en]

The present study shows that polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) can interact and enhance developmental neurobehavioral defects when the exposure occurs during a critical stage of neonatal brain development. PBDEs are used in large quantities as flame-retardant additives in polymers, especially in the manufacture of a great variety of electrical appliances, and textiles. In contrast to the well-known persistent compounds PCBs and DDT, the PBDEs have been found to increase in the environment and in human mother's milk. We have previously shown that low-dose exposure to environmental toxic agents such as PCB can cause developmental neurotoxic effects when present during a critical stage of neonatal brain development. Epidemiological studies indicate the adverse neurobehavioral impact of PCBs. Recently, we reported that neonatal exposure to PBDEs causes developmental neurotoxic effects. In the present study, 10-day-old Naval Medical Research Institute male mice were given one single oral dose of PCB 52 (1.4 mu mol/kg body weight [bw]) + PBDE 99 (1.4 mu mol), PCB 52 (1.4 mu mol or 14 mu mol), or PBDE 99 (1.4 mu mol or 14 mu mol). Controls received a vehicle (20% fat emulsion). Animals exposed to the combined dose of PCB 52 (1.4 mu mol) + PBDE 99 (1.4 mu mol) and the high dose of PCB 52 (14 mu mol) or PBDE 99 (14 mu mol) showed significantly impaired spontaneous motor behavior and habituation capability at the age of 4 and 6 months. The neurobehavioral defects were also seen to worsen with age in mice neonatally exposed to PCB 52 + PBDE 99.

Keywords
PBDE, PCB, brominated flame retardants, behavior, habituation, neonatal, neurotoxicity
National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-96658 (URN)10.1093/toxsci/kfl109 (DOI)000242273400008 ()16980691 (PubMedID)
Available from: 2008-01-18 Created: 2008-01-18 Last updated: 2017-12-14Bibliographically approved
Fischer, C., Fredriksson, A. & Eriksson, P. (2005). Neonatal exposure to a single low dose of a type I pyrethroid (bioallethrin) affects spontaneous behaviour and learning in adult mice of different strains. In: Toxicologist 84 (pp. 975).
Open this publication in new window or tab >>Neonatal exposure to a single low dose of a type I pyrethroid (bioallethrin) affects spontaneous behaviour and learning in adult mice of different strains
2005 (English)In: Toxicologist 84, 2005, p. 975-Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-78231 (URN)
Available from: 2006-03-20 Created: 2006-03-20
Fischer, C., Fredriksson, A. & Eriksson, P. (2004). Co-exposure to an ortho-substituted PCB (PCB 153) and methylmercury enhances developmental neurotoxic effects. In: Organohalogen Compounds (pp. 66:3160-3162).
Open this publication in new window or tab >>Co-exposure to an ortho-substituted PCB (PCB 153) and methylmercury enhances developmental neurotoxic effects
2004 (English)In: Organohalogen Compounds, 2004, p. 66:3160-3162Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-67150 (URN)
Available from: 2006-03-20 Created: 2006-03-20
Eriksson, P., Johansson, N., Viberg, H., Fischer, C. & Fredriksson, A. (2004). Comparative developmental neurotoxicity of flame-retardants, polybrominated flame-retardants and organophosphorous compounds, in mice. In: Organohalogen Compounds (pp. 66:3163-3165).
Open this publication in new window or tab >>Comparative developmental neurotoxicity of flame-retardants, polybrominated flame-retardants and organophosphorous compounds, in mice
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2004 (English)In: Organohalogen Compounds, 2004, p. 66:3163-3165Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-67149 (URN)
Available from: 2006-03-20 Created: 2006-03-20
Fischer, C., Fredriksson, A. & Eriksson, P. (2004). Neonatal exposure to a single low dose of a type 1 pyrethroid (bioallethrin) affects spontaneous behaviour and learning in adult mice of different strains. In: The Toxicologist (pp. 975).
Open this publication in new window or tab >>Neonatal exposure to a single low dose of a type 1 pyrethroid (bioallethrin) affects spontaneous behaviour and learning in adult mice of different strains
2004 (English)In: The Toxicologist, 2004, p. 975-Conference paper, Published paper (Refereed)
Identifiers
urn:nbn:se:uu:diva-22985 (URN)
Available from: 2007-01-24 Created: 2007-01-24
Eriksson, P., Fischer, C. & Fredriksson, A. (2003). Co-exposure to a polybrominated diphenyl ether (PBDE 99) and an ortho-substituted PCB (PCB 52) enhances developmental neurotoxic effects. In: Organohalogen compounds.
Open this publication in new window or tab >>Co-exposure to a polybrominated diphenyl ether (PBDE 99) and an ortho-substituted PCB (PCB 52) enhances developmental neurotoxic effects
2003 (English)In: Organohalogen compounds, 2003Conference paper, Published paper (Other scientific)
Identifiers
urn:nbn:se:uu:diva-67114 (URN)
Available from: 2006-03-20 Created: 2006-03-20
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