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Brattstrom, Daniel
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Publications (9 of 9) Show all publications
Bolander, Å., Wagenius, G., Larsson, A., Brattström, D., Ullenhag, G., Hesselius, P., . . . Bergqvist, M. (2007). The Role of Circulating Angiogenic Factors in Patients Operated on for Localized Malignant Melanoma. Anticancer Research, 27(5A), 3211-3217
Open this publication in new window or tab >>The Role of Circulating Angiogenic Factors in Patients Operated on for Localized Malignant Melanoma
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2007 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 27, no 5A, p. 3211-3217Article in journal (Refereed) Published
Abstract [en]

Malignant melanoma is a disease capable of rapid progression and rapidly developing metastases. Angiogenesis is a key event signalling tumour progression and elevated levels of angiogenic markers may indicate metastatic disease. No previously published work has, so far, examined plasma vascular endothelial growth factor (VEGF) and its receptor, VEGFR-1, in melanoma. This study investigated circulating levels of the angiogenic factors, VEGF-A and -D, their receptors 1-3 and hepatocyte growth factor (HGF)/scatter factor, in patients shortly after primary surgery for localized malignant melanoma. Elevated circulating levels of VEGF and its receptors, and of HGF, were found postoperatively, possibly derived from the reactive stroma adjacent to the tumours. Using univariate analysis, a correlation between levels of VEGFR-1 and relapse was found, but a correlation between the investigated angiogenic factors and survival could not be established. The results of the present study indicate that production of these angiogenic factors may be due to sources other than malignant melanoma cells.

Keywords
Malignant melanoma, angiogenesis, survival, relapse, vascular endothelial growth factor, hepatocyte growth factor, hepatocyte scatter factor
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-97931 (URN)000250266600022 ()17970063 (PubMedID)
Available from: 2008-12-22 Created: 2008-12-22 Last updated: 2017-12-14Bibliographically approved
Eriksson, P., Brattström, D., Hesselius, P., Larsson, A., Bergström, S., Ekman, S., . . . Bergqvist, M. (2006). Role of circulating cytokeratin fragments and angiogenic factors in NSCLC patients stage IIIa-IIIb receiving curatively intended treatment.. Neoplasma, 53(4), 285-90
Open this publication in new window or tab >>Role of circulating cytokeratin fragments and angiogenic factors in NSCLC patients stage IIIa-IIIb receiving curatively intended treatment.
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2006 (English)In: Neoplasma, ISSN 0028-2685, Vol. 53, no 4, p. 285-90Article in journal (Refereed) Published
Keywords
Carcinoma; Non-Small-Cell Lung/*diagnosis/therapy, Female, Fibroblast Growth Factor 2/*blood, Humans, Immunohistochemistry/methods, Keratins/*blood, Lung Neoplasms/*diagnosis/therapy, Male, Risk, Survival Analysis, Tumor Markers; Biological/*blood, Vascular Endothelial Growth Factor A/*blood
Identifiers
urn:nbn:se:uu:diva-21811 (URN)16830054 (PubMedID)
Available from: 2007-01-04 Created: 2007-01-04 Last updated: 2011-01-11
Hellman, B., Brodin, D., Andersson, M., Dahlman-Wright, K., Isacsson, U., Brattstrom, D. & Bergqvist, M. (2005). Radiation-induced DNA-damage and gene expression profiles in human lung cancer cells with different radiosensitivity.. Exp Oncol, 27(2), 102-7
Open this publication in new window or tab >>Radiation-induced DNA-damage and gene expression profiles in human lung cancer cells with different radiosensitivity.
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2005 (English)In: Exp Oncol, ISSN 1812-9269, Vol. 27, no 2, p. 102-7Article in journal (Refereed) Published
Keywords
Carcinoma; Large Cell/genetics/metabolism/pathology, Carcinoma; Small Cell/genetics/metabolism/pathology, Comet Assay, Comparative Study, DNA Damage, DNA; Neoplasm/*radiation effects, Gamma Rays, Gene Expression/*radiation effects, Gene Expression Profiling, Humans, Lung Neoplasms/*genetics/metabolism/pathology, Oligonucleotide Array Sequence Analysis, Radiation Tolerance, Research Support; Non-U.S. Gov't, Tumor Cells; Cultured, Tumor Markers; Biological/*metabolism
Identifiers
urn:nbn:se:uu:diva-79647 (URN)15995626 (PubMedID)
Available from: 2007-03-23 Created: 2007-03-23 Last updated: 2011-01-11
Dreilich, M., Bergström, S., Wagenius, G., Brattström, D. & Bergqvist, M. (2004). A retrospective study focusing on clinical predictive factors in 126 patients with oesophageal carcinoma.. Anticancer Res, 24(3b), 1915-20
Open this publication in new window or tab >>A retrospective study focusing on clinical predictive factors in 126 patients with oesophageal carcinoma.
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2004 (English)In: Anticancer Res, ISSN 0250-7005, Vol. 24, no 3b, p. 1915-20Article in journal (Other scientific) Published
Keywords
Aged, Esophageal Neoplasms/*drug therapy/pathology/*radiotherapy, Female, Humans, Male, Neoplasm Staging, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Treatment Outcome
Identifiers
urn:nbn:se:uu:diva-69920 (URN)15274376 (PubMedID)
Available from: 2005-04-12 Created: 2005-04-12 Last updated: 2011-01-12
Brattström, D., Bergqvist, M., Wester, K., Hesselius, P., Ren, Z.-P., Scheibenpflug, L., . . . Brodin, O. (2004). Endothelial markers and circulating angiogenic factors and p53 may be potential markers for recurrence in surgically resected non-small cell lung cancer patients.. Med Sci Monit, 10(9), BR331-8
Open this publication in new window or tab >>Endothelial markers and circulating angiogenic factors and p53 may be potential markers for recurrence in surgically resected non-small cell lung cancer patients.
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2004 (English)In: Med Sci Monit, ISSN 1234-1010, Vol. 10, no 9, p. BR331-8Article in journal (Other scientific) Published
Keywords
Adult, Aged, Aged; 80 and over, Angiogenic Proteins/*metabolism, Antigens; CD34/genetics/metabolism, Biological Markers, Carcinoma; Non-Small-Cell Lung/*metabolism/pathology/surgery, Endothelial Cells/*metabolism, Endothelium; Vascular/cytology/metabolism, Female, Humans, Lung Neoplasms/*metabolism/pathology/surgery, Male, Middle Aged, Prognosis, Protein p53/genetics/*metabolism, Recurrence, Research Support; Non-U.S. Gov't, Risk Factors, Statistics, Survival Rate, Vascular Cell Adhesion Molecule-1/genetics/metabolism
Identifiers
urn:nbn:se:uu:diva-69919 (URN)15328478 (PubMedID)
Available from: 2007-04-19 Created: 2007-04-19 Last updated: 2011-01-12
Brattström, D., Wester, K., Bergqvist, M., Hesselius, P., Malmström, P.-U., Nordgren, H., . . . Brodin, O. (2004). HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer.. Acta Oncol, 43(1), 80-6
Open this publication in new window or tab >>HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer.
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2004 (English)In: Acta Oncol, ISSN 0284-186X, Vol. 43, no 1, p. 80-6Article in journal (Refereed) Published
Keywords
Adult, Aged, Aged; 80 and over, Biopsy; Needle, Capillaries/physiopathology, Carcinoma; Non-Small-Cell Lung/genetics/*mortality/pathology, Cohort Studies, Female, Gene Expression Regulation; Neoplastic, Humans, Immunohistochemistry, Isoenzymes/genetics/*metabolism, Lung Neoplasms/genetics/*mortality/pathology, Male, Middle Aged, Neoplasm Staging, Pneumonectomy, Probability, Prognosis, Proportional Hazards Models, Prostaglandin-Endoperoxide Synthase/genetics/*metabolism, Receptor; Epidermal Growth Factor/genetics/*metabolism, Receptor; erbB-2/genetics/*metabolism, Research Support; Non-U.S. Gov't, Retrospective Studies, Sensitivity and Specificity, Survival Analysis, Tumor Markers; Biological/*analysis
Identifiers
urn:nbn:se:uu:diva-69921 (URN)15068324 (PubMedID)
Available from: 2005-07-28 Created: 2005-07-28 Last updated: 2011-01-12
Garpenstrand, H., Bergqvist, M., Brattström, D., Larsson, A., Oreland, L., Hesselius, P. & Wagenius, G. (2004). Serum semicarbazide-sensitive amine oxidase (SSAO) activity correlates with VEGF in non-small-cell lung cancer patients.. Med Oncol, 21(3), 241-50
Open this publication in new window or tab >>Serum semicarbazide-sensitive amine oxidase (SSAO) activity correlates with VEGF in non-small-cell lung cancer patients.
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2004 (English)In: Med Oncol, ISSN 1357-0560, Vol. 21, no 3, p. 241-50Article in journal (Refereed) Published
Keywords
Adenocarcinoma/blood/pathology, Amine Oxidase (Copper-Containing)/*blood, Carcinoma; Non-Small-Cell Lung/*blood/mortality/pathology, Carcinoma; Squamous Cell/blood/pathology, Comparative Study, Enzyme-Linked Immunosorbent Assay, Female, Fibroblast Growth Factor 2/*blood, Humans, Immunoassay, Lung Neoplasms/*blood/mortality/pathology, Male, Neoplasm Staging, Neovascularization; Pathologic, Prognosis, Radiochemistry, Research Support; Non-U.S. Gov't, Survival Analysis, Time Factors, Vascular Endothelial Growth Factor A/*blood
Identifiers
urn:nbn:se:uu:diva-69915 (URN)15456951 (PubMedID)
Available from: 2005-05-27 Created: 2005-05-27 Last updated: 2018-05-31
Bergström, S., Dreilich, M., Wagenius, G., Brattström, D., Larsson, A., Hesselius, P. & Bergqvist, M. (2004). The presence of anti-p53 antibodies in sera from patients with oesophageal carcinoma: correlation to treatment, tumour volume and survival.. In Vivo, 18(5), 615-20
Open this publication in new window or tab >>The presence of anti-p53 antibodies in sera from patients with oesophageal carcinoma: correlation to treatment, tumour volume and survival.
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2004 (English)In: In Vivo, ISSN 0258-851X, Vol. 18, no 5, p. 615-20Article in journal (Refereed) Published
Keywords
Adenocarcinoma/*immunology/mortality/pathology/therapy, Antibodies; Neoplasm/*blood, Carcinoma; Squamous Cell/*immunology/mortality/pathology/therapy, Combined Modality Therapy, Enzyme-Linked Immunosorbent Assay, Esophageal Neoplasms/*immunology/mortality/pathology/therapy, Female, Humans, Male, Palliative Care, Preoperative Care, Protein p53/*immunology, Survival Rate
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-69911 (URN)15523902 (PubMedID)
Available from: 2005-05-27 Created: 2005-05-27 Last updated: 2011-01-12
Bergqvist, M., Brattström, D., Larsson, A., Hesselius, P., Brodin, O. & Wagenius, G. (2004). The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival.. BMC Cancer, 4(1), 66
Open this publication in new window or tab >>The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival.
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2004 (English)In: BMC Cancer, ISSN 1471-2407, Vol. 4, no 1, p. 66-Article in journal (Refereed) Published
Keywords
Adenocarcinoma/immunology, Antibodies/*blood, Carcinoma; Non-Small-Cell Lung/*immunology/mortality/pathology, Carcinoma; Squamous Cell/immunology, Disease Progression, Female, Humans, Lung Neoplasms/*immunology/mortality/pathology, Male, Neoplasm Staging, Protein p53/*immunology, Research Support; Non-U.S. Gov't, Survival Analysis, Survival Rate
Identifiers
urn:nbn:se:uu:diva-69918 (URN)15367333 (PubMedID)
Available from: 2005-05-27 Created: 2005-05-27 Last updated: 2011-01-12
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