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Ekberg, Thomas
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Publications (5 of 5) Show all publications
Coelho, R., Ekberg, T., Svensson, M., Mani, M. & Rodriguez-Lorenzo, A. (2017). Reconstruction of late esophagus perforation after anterior cervical spine fusion with an adipofascial anterolateral thigh free flap: A case report.. Microsurgery, 37(6), 684-688
Open this publication in new window or tab >>Reconstruction of late esophagus perforation after anterior cervical spine fusion with an adipofascial anterolateral thigh free flap: A case report.
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2017 (English)In: Microsurgery, ISSN 0738-1085, E-ISSN 1098-2752, Vol. 37, no 6, p. 684-688Article in journal (Refereed) Published
Abstract [en]

Reconstruction of late esophageal perforation usually requires flap surgery to achieve wound healing. However, restoring the continuity between the digestive tract and retropharyngeal space to allow for normal swallowing remains a technical challenge. In this report, we describe the use of a thin and pliable free adipofascial anterolateral thigh (ALT) flap in a 47-year-old tetraplegic man with a history of C5-C6 fracture presented with a large posterior esophagus wall perforation allowing an easier flap insetting for a successful wound closure. The postoperative course was uneventful and mucosalization of the flap was confirmed by esophagoscopy 4 weeks postsurgery. The patient tolerated normal diet and maintained normal swallowing during a follow-up of 3 years postoperatively. The adipofascial ALT flap may provide easier insetting due to the thin and pliable layer of adipofascial tissue for reconstructing large defects of the posterior wall of the esophagus by filling the retroesophageal space.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-335300 (URN)10.1002/micr.30170 (DOI)000411186900030 ()28397296 (PubMedID)
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2018-01-19Bibliographically approved
Borota, L., Mahmoud, E., Nyberg, C. & Ekberg, T. (2015). Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 21(3), 390-396
Open this publication in new window or tab >>Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique
2015 (English)In: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, ISSN 1591-0199, Vol. 21, no 3, p. 390-396Article in journal (Refereed) Published
Abstract [en]

Juvenile nasal angiofibroma (JNA) is a hypervascularised, benign, but locally aggressive tumour that grows in the posterior, upper part of the nasal cavity and invades surrounding anatomical structures. The treatment of choice is surgical removal, but complete resection of the tumour can be hampered because of profuse perioperative bleeding. Preoperative embolisation of the tumour has been proposed as an effective method for prevention of perioperative bleeding, thereby shortening of the time of the operation. In this report of five cases, we describe successful preoperative devascularisation of the tumour by applying a modified method of direct intratumoural injection of the liquid embolic agent Onyx combined with protection of the internal carotid artery. The control of bleeding during the embolisation and occlusion of the maxillary or sphenopalatine artery was achieved by using a bi-luminal balloon catheter. Such use of the dual-lumen catheter in treatment of JNA has not been reported so far in the medical literature.

National Category
Neurosciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-253999 (URN)10.1177/1591019915581988 (DOI)000356305000018 ()25991005 (PubMedID)
Available from: 2015-06-04 Created: 2015-06-04 Last updated: 2018-01-11Bibliographically approved
Rodriguez-Lorenzo, A., Rydevik Mani, M., Thor, A., Gudjonsson, O., Marklund, N., Olerud, C. & Ekberg, T. (2014). Fibula osteo-adipofascial flap for reconstruction of a cervical spine and posterior pharyngeal wall defect. Microsurgery, 34(4), 314-318
Open this publication in new window or tab >>Fibula osteo-adipofascial flap for reconstruction of a cervical spine and posterior pharyngeal wall defect
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2014 (English)In: Microsurgery, ISSN 0738-1085, E-ISSN 1098-2752, Vol. 34, no 4, p. 314-318Article in journal (Refereed) Published
Abstract [en]

When reconstructing combined defects of the cervical spine and the posterior pharyngeal wall the goals are bone stability along with continuity of the aerodigestive tract. We present a case of a patient with a cervical spine defect, including C1 to C3, associated with a posterior pharyngeal wall defect after excision of a chordoma and postoperative radiotherapy. The situation was successfully solved with a free fibula osteo-adipofascial flap. The reconstruction with a fibula osteo-adipofascial flap provided several benefits in comparison with a fibula osteo-cutaneous flap in our case, including an easier insetting of the soft tissue component at the pharyngeal level and less bulkiness of the flap allowing our patient to resume normal deglutition.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-216206 (URN)10.1002/micr.22217 (DOI)000333808000012 ()24375861 (PubMedID)
Available from: 2014-01-20 Created: 2014-01-20 Last updated: 2018-05-25Bibliographically approved
Cheng, J., Engström, M., Ekberg, T., Nestor, M., Anniko, M. & Tolmachev, V. (2010). The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36. Molecular Medicine Reports, 3(1), 155-160
Open this publication in new window or tab >>The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36
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2010 (English)In: Molecular Medicine Reports, ISSN 1791-2997, Vol. 3, no 1, p. 155-160Article in journal (Refereed) Published
Abstract [en]

Radionuclide imaging of head and neck squamous cell carcinoma (HNSCC) using monoclonal antibodies (MAbs) has the potential to contribute to improved diagnosis and staging, thereby making more effective treatment possible. Chimeric monoclonal antibody U36 (cMAb U36), specific to CD44v6 antigen. is a candidate for the targeting of HNSCC. The aim of this study was to compare the influence of indirect iodination via closo-dodecaborate-based linker (DABI) with the influence of direct radioiodination on the biodistribution of the chimeric anti-CD44v6 antibody U36. The study was performed using nude mice bearing UT-SCC7 HNSCC xenografts using the paired-label method. The biodistribution of cMAb U36 labelled directly with I-131 and using DABI with I-125 was compared in the same animals. The influence of DABI on the tumour-to-organ ratio was evaluated. For both conjugates, radioactivity uptake in blood and organs decreased with time, except in tumours and the thyroid. DABI-labelled cMAb U36 was characterised by fast blood clearance and an elevated uptake in the liver and spleen. The use of DABI enabled a 1.5 to 2-fold improvement in the tumour-to-blood and tumour-to-organ ratios in comparison with direct radioiodination, with the exception of the liver and spleen. These results indicate that DABI is a promising linker for the coupling of radioiodine to HNSCC-targeting antibodies.

Keywords
nude mice, chimeric monoclonal antibody U36, head and neck squamous cell carcinoma, tumour transplantation, tumour targeting
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-127366 (URN)10.3892/mmr_00000233 (DOI)000272753700023 ()
Available from: 2010-07-13 Created: 2010-07-13 Last updated: 2015-02-27Bibliographically approved
Ekberg, T., Nestor, M., Engström, M., Nordgren, H., Wester, K., Carlsson, J. & Anniko, M. (2005). Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue. International Journal of Oncology, 26(5), 1177-85
Open this publication in new window or tab >>Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue
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2005 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 26, no 5, p. 1177-85Article in journal (Refereed) Published
Abstract [en]

The expressions of all four receptors in the epidermal growth factor receptor family, EGFR. HER2, HER3, and HER4 were evaluated by immunohistochemistry in 19 cases of metastatic squamous cell carcinoma of the oral cavity and base of tongue. EGFR had a similar and high expression in both primary tumours and the corresponding metastases, while the expression in normal epithelium was lower in most cases. HER2 was not expressed to the same extent as EGFR. However, when HER2 was well expressed, it was in most cases expressed to the same extent and intensity in the primary tumours, metastases, and normal epithelium. The expression of HER3 and HER4 varied and was mainly cytoplasmic in all cases studied. No overexpression of HER3 and HER4 in tumours was seen as compared to normal epithelium. In order to further investigate the distribution of HER3, two HER3 expressing cell lines originating from tongue cancer were analysed in vitro, using radiolabelled anti-HER3 antibodies directed to the extracellular domains of the receptor. The results indicated that HER3 was not present in measurable amounts in the cellular membrane. There is a need for improved diagnostics and therapy for the studied type of tumours, e.g. using radiolabelled antibodies or ligands, and EGFR seemed suitable as target since the expression was high, membrane associated and similar in the primary tumours and the corresponding metastases.

Keywords
Aged, Aged; 80 and over, Carcinoma; Squamous Cell/*genetics/pathology, Comparative Study, Female, Gene Expression Profiling, Humans, Immunohistochemistry, Ligands, Male, Middle Aged, Receptor; Epidermal Growth Factor/analysis/*biosynthesis, Receptor; erbB-2/analysis/*biosynthesis, Receptor; erbB-3/analysis/*biosynthesis, Research Support; Non-U.S. Gov't, Tongue Neoplasms/*genetics/pathology, Tumor Cells; Cultured
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-80655 (URN)15809707 (PubMedID)
Available from: 2008-02-19 Created: 2008-02-19 Last updated: 2017-12-14Bibliographically approved
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