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Forsgren, Johan
Alternative names
Publications (10 of 55) Show all publications
Muelhopt, S., Diabate, S., Dilger, M., Adelhelm, C., Anderlohr, C., Bergfeldt, T., . . . Paur, H.-R. (2018). Characterization of Nanoparticle Batch-To-Batch Variability. NANOMATERIALS, 8(5), Article ID 311.
Open this publication in new window or tab >>Characterization of Nanoparticle Batch-To-Batch Variability
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2018 (English)In: NANOMATERIALS, ISSN 2079-4991, Vol. 8, no 5, article id 311Article in journal (Refereed) Published
Abstract [en]

A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.

Place, publisher, year, edition, pages
MDPI, 2018
Keywords
nanosafety, particle size, impurities, reactive oxygen species
National Category
Pharmacology and Toxicology Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-358558 (URN)10.3390/nano8050311 (DOI)000435198300042 ()29738461 (PubMedID)
Funder
EU, FP7, Seventh Framework Programme, INFRA-2010-262163
Available from: 2018-09-21 Created: 2018-09-21 Last updated: 2018-10-09Bibliographically approved
Zhang, P., Gómez de La Torre, T. Z., Forsgren, J., Bergström, C. & Strömme, M. (2016). Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®. Journal of Pharmaceutical Sciences, 105(2), 657-663
Open this publication in new window or tab >>Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®
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2016 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 105, no 2, p. 657-663Article in journal (Refereed) Published
Abstract [en]

In vitro drug release from well-defined particle-size fractions of the mesoporous magnesium carbonate material Upsalite® was investigated in detail using ibuprofen, a biopharmaceutics classification system class II drug, as the model compound. The weight of loaded drug corresponded to 30% of the weight of the carrier and the pores were filled to approximately 80%. The incorporated ibuprofen was found to be in an amorphous state and was physisorbed, rather than chemisorbed, to the surfaces of the pore walls. In contrast to ibuprofen in mesoporous silica, there was no detectable drug on the outer surface of the carrier particles. Two ibuprofen doses were loaded into Upsalite® particles with size fractions ranging from 25 μm to more than 200 μm. The initial release rate was controlled by the particle size; the dissolution rate of the loaded ibuprofen during this period was more than four times faster than that of the crystalline drug. An extended-release period of about 24 h followed the initial rapid-release period. The features of this extended-release period were dependent on the total drug concentration in the release medium. Detailed analysis of the diffusion of ibuprofen in Upsalite® provided the ibuprofen diffusion coefficient (9.8 × 10−8 cm2/s), the constrictivity of the diffusion process (0.47) and the tortuosity of the carrier (15). This relatively high tortuosity value indicates that Upsalite® can be used not only to enhance the dissolution rate of poorly soluble drugs but also as a carrier in sustained-release applications by using larger particle sizes or even pellets of the material.

Keywords
mesoporous material, Upsalite®, poorly soluble drugs, diffusion, constrictivity, tortuosity, controlled release, ibuprofen, magnesium carbonate
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-255928 (URN)10.1002/jps.24553 (DOI)000381768500029 ()26087956 (PubMedID)
Funder
VINNOVAEU, European Research CouncilSwedish Research Council
Available from: 2015-06-19 Created: 2015-06-19 Last updated: 2017-12-04Bibliographically approved
Frykstrand, S., Forsgren, J., Cheung, O., Zhang, P., Hong, J., Strømme, M. & Ferraz, N. (2016). Study of mesoporous magnesium carbonate in contact with whole human blood. RSC Advances, 6(58), 52810-52816
Open this publication in new window or tab >>Study of mesoporous magnesium carbonate in contact with whole human blood
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2016 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 58, p. 52810-52816Article in journal (Refereed) Published
Abstract [en]

The interaction of mesoporours magnesium carbonate (Upsalite) particles (50-100 mm) with human whole blood was investigated using an in vitro loop model and the effect on the complement system, blood coagulation and red blood cell lysis was assessed. The removal of Ca2+ by Upsalite and the possible exchange with and/or release of Mg2+ were explored as well. Upsalite was found to present anticoagulant properties, most probably due to the uptake of Ca2+ by the particles. No hemolytic activity was detected at Upsalite concentrations up to 1 mg ml(-1). Moderate to high levels of C3a and sC5b-9 were observed for Upsalite, however such levels were statistically different from the negative control only when the particle concentrations were 0.25 mg ml(-1) and 1.0 mg ml(-1), respectively. The presented findings are promising for the future development of mesoporous magnesium carbonate-based materials for biomedical applications.

National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-281465 (URN)10.1039/c6ra05679b (DOI)000378563200037 ()2-s2.0-84973390611 (Scopus ID)
Funder
Swedish Research Council
Available from: 2016-03-24 Created: 2016-03-24 Last updated: 2019-03-25Bibliographically approved
Strömme, M., Frykstrand, S., Zhang, P., Lindh, J., Ferraz, N., Forsgren, J., . . . Mihranyan, A. (2015). From porous nanocellulose composites in life science and energy storage to mesoporous magnesium carbonate as drug solubility enhancer . In: Elsevier (Ed.), Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015. Paper presented at Fourth International Conference on Multifunctional, Hybrid and Nanomaterials (pp. OPC.07.07). , 4
Open this publication in new window or tab >>From porous nanocellulose composites in life science and energy storage to mesoporous magnesium carbonate as drug solubility enhancer
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2015 (English)In: Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015 / [ed] Elsevier, 2015, Vol. 4, p. OPC.07.07-Conference paper, Oral presentation with published abstract (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-245772 (URN)
Conference
Fourth International Conference on Multifunctional, Hybrid and Nanomaterials
Available from: 2015-02-28 Created: 2015-02-28 Last updated: 2016-11-30
Zhang, P., Forsgren, J. & Strömme, M. (2015). Mesoporous Magnesium Carbonate - Upsalite® - as Phase Stabilizer of Amorphous Ibuprofen . In: 6th Symposium on pharmaceutical profiling in drug discovery and development: . Paper presented at 6th Symposium on pharmaceutical profiling in drug discovery and development , January 28 2015, UPPSALA Sweden. Uppsala, 6
Open this publication in new window or tab >>Mesoporous Magnesium Carbonate - Upsalite® - as Phase Stabilizer of Amorphous Ibuprofen
2015 (English)In: 6th Symposium on pharmaceutical profiling in drug discovery and development, Uppsala, 2015, Vol. 6Conference paper, Poster (with or without abstract) (Refereed)
Place, publisher, year, edition, pages
Uppsala: , 2015
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-248598 (URN)
Conference
6th Symposium on pharmaceutical profiling in drug discovery and development , January 28 2015, UPPSALA Sweden
Available from: 2015-04-01 Created: 2015-04-01 Last updated: 2016-11-30
Forsgren, J., Frykstrand, S., Zhang, P., Mihranyan, A. & Strömme, M. (2015). Porous alkali earth metal carbonates as enhancers of solubility for poorly soluble drugs. In: Nanotechnologies in Drug Delivery, London 2015: . Paper presented at Nanotechnologies in Drug Delivery, 27 – 28 April 2015, London, United Kingdom..
Open this publication in new window or tab >>Porous alkali earth metal carbonates as enhancers of solubility for poorly soluble drugs
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2015 (English)In: Nanotechnologies in Drug Delivery, London 2015, 2015Conference paper, Poster (with or without abstract) (Refereed)
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-268474 (URN)
Conference
Nanotechnologies in Drug Delivery, 27 – 28 April 2015, London, United Kingdom.
Available from: 2015-12-05 Created: 2015-12-05 Last updated: 2016-11-30
Frykstrand, S., Forsgren, J., Mihranyan, A., Ferraz, N. & Strömme, M. (2015). Synthesis and potential of Upsalite®: a mesoporous magnesium carbonate synthesized without surfactants. In: Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015. Paper presented at Fourth International Conference on Multifunctional, Hybrid and Nanomaterials (pp. P1.225). Stiges
Open this publication in new window or tab >>Synthesis and potential of Upsalite®: a mesoporous magnesium carbonate synthesized without surfactants
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2015 (English)In: Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015, Stiges, 2015, p. P1.225-Conference paper, Poster (with or without abstract) (Refereed)
Place, publisher, year, edition, pages
Stiges: , 2015
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-245773 (URN)
Conference
Fourth International Conference on Multifunctional, Hybrid and Nanomaterials
Available from: 2015-02-28 Created: 2015-02-28 Last updated: 2018-05-28
Zhang, P., Forsgren, J. & Strömme, M. (2015). Upsalite® - Nanoporous Magnesium Carbonate - as Phase Stabilizer of Amorphous Ibuprofen. In: Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015. Paper presented at Fourth International Conference on Multifunctional, Hybrid and Nanomaterials (pp. P2.039). Stiges
Open this publication in new window or tab >>Upsalite® - Nanoporous Magnesium Carbonate - as Phase Stabilizer of Amorphous Ibuprofen
2015 (English)In: Fourth International Conference on Multifunctional, Hybrid and Nanomaterials: Hybrid Materials 2015, Stiges, 2015, p. P2.039-Conference paper, Poster (with or without abstract) (Refereed)
Place, publisher, year, edition, pages
Stiges: , 2015
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-245774 (URN)
Conference
Fourth International Conference on Multifunctional, Hybrid and Nanomaterials
Available from: 2015-02-28 Created: 2015-02-28 Last updated: 2016-11-30
Carlsson, D. O., Hua, K., Mihranyan, A. & Forsgren, J. (2014). Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose. International Journal of Pharmaceutics, 461, 74-81
Open this publication in new window or tab >>Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose
2014 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 461, p. 74-81Article in journal (Refereed) Published
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-239798 (URN)
Available from: 2014-12-30 Created: 2014-12-30 Last updated: 2017-12-05
Frykstrand, S., Forsgren, J., Strømme, M. & Ferraz, N. (2014). Cytotoxicity and in vivo irritation of Upsalite®, a mesoporous magnesium carbonate . In: : . Paper presented at 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine.
Open this publication in new window or tab >>Cytotoxicity and in vivo irritation of Upsalite®, a mesoporous magnesium carbonate
2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-235841 (URN)
Conference
26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
Available from: 2014-11-11 Created: 2014-11-11 Last updated: 2016-11-30
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