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Bergman, Antonina
Alternative names
Publications (10 of 15) Show all publications
Jonsdottir, B., Ripoll, M. A., Bergman, A., Silins, I., Sundström Poromaa, I., Ahlström, H. & Stålberg, K. (2017). Comparison Of Pet-Mri And Mri Alone Predicting Carcinomatosis In Ovarian Cancer Using Peritoneal Cancer Index (Pci). Paper presented at 20th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria, November 4-7, 2017.. International Journal of Gynecological Cancer, 27(Supplement: 4), 300-301
Open this publication in new window or tab >>Comparison Of Pet-Mri And Mri Alone Predicting Carcinomatosis In Ovarian Cancer Using Peritoneal Cancer Index (Pci)
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2017 (English)In: International Journal of Gynecological Cancer, ISSN 1048-891X, E-ISSN 1525-1438, Vol. 27, no Supplement: 4, p. 300-301Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-350123 (URN)10.1097/01.IGC.0000527296.86225.87 (DOI)000423235201288 ()
Conference
20th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria, November 4-7, 2017.
Note

Meeting Abstract: ESGO7-085

Also, Meeting Abstract: ESGO7-085, Pages: 1532-1533.

And, WoS: 000423235204214, title: D Comparison Of Pet-Mri And Mri Alone Predicting Carcinomatosis In Ovarian Cancer Using Peritoneal Cancer Index (Pci)

Available from: 2018-05-07 Created: 2018-05-07 Last updated: 2018-05-18Bibliographically approved
Torkzad, M., Casta, N., Bergman, A., Ahlström, H., Påhlman, L. & Mahteme, H. (2015). Comparison between MRI and CT in prediction of peritoneal carcinomatosis index (PCI) in patients undergoing cytoreductive surgery in relation to the experience of the radiologist. Journal of Surgical Oncology, 111(6), 746-751
Open this publication in new window or tab >>Comparison between MRI and CT in prediction of peritoneal carcinomatosis index (PCI) in patients undergoing cytoreductive surgery in relation to the experience of the radiologist
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2015 (English)In: Journal of Surgical Oncology, ISSN 0022-4790, E-ISSN 1096-9098, Vol. 111, no 6, p. 746-751Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

To compare CT and MRI for peritoneal carcinomatosis index (PCI) assessment and to compare assessments made by the radiologist based on their experiences.

METHOD AND MATERIALS:

MRI and CT of abdomen and pelvis were performed on 39 prospectively followed by surgery directly. Two blinded radiologists with different experience levels evaluated PCI separately on different occasions on 19 cases initially and later on the remaining 20. The agreement between the radiologists' assessment and surgical findings in total and per site were recorded.

RESULTS:

Total PCI: The experienced radiologist was able to assess total tumor burden correctly on both CT and MRI (kappa = 1.0). For the inexperienced radiologist the assessment was better on CT (kappa = 0.73) compared to MRI (kappa = 0.58). Different sites: The experienced radiologist showed high agreement with kappa = 0.77 for MRI and 0.80 for CT. Corresponding figures were 0.39 and 0.60 for the inexperienced radiologist. For the second phase the agreement levels increased for the inexperienced radiologist increased to 0.80 and 0.70, respectively.

CONCLUSION:

CT and MRI are equal when read by experienced radiologist. CT shows better results when read by an inexperienced radiologist compared to MRI, however the results of the latter can easily be improved.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-244159 (URN)10.1002/jso.23878 (DOI)000353417700014 ()25580825 (PubMedID)
Available from: 2015-02-12 Created: 2015-02-12 Last updated: 2017-12-04Bibliographically approved
Grevfors, N., Torkzad, M. R., Bergman, A. & Påhlman, L. (2012). Can acute abdominal CT prioritise patients with suspected diverticulitis for a subsequent clean colonic examination?. Colorectal Disease, 14(7), 893-896
Open this publication in new window or tab >>Can acute abdominal CT prioritise patients with suspected diverticulitis for a subsequent clean colonic examination?
2012 (English)In: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318, Vol. 14, no 7, p. 893-896Article in journal (Refereed) Published
Abstract [en]

Aim: 

The aim of this study was to investigate whether patients with diverticulitis can be prioritised with higher urgency for a subsequent full colonic examination based upon the emergency abdominal computerised tomography (CT) at the time of presentation.

Method:

All patients with a diagnosis of diverticulitis hospitalized during 2006 having CT on admission and a subsequent 'clean colon' examination were reviewed. The CT was reviewed by two independent and blinded senior radiologists (A and B) for signs inconsistent with diverticulitis and suggestive of malignancy. The patients were classified on CT into group 1 (normal findings, non-tumour pathology or benign polyps < 1 cm) and group 2 (benign polyps ≥ 1 cm and cancer).

Results: 

93 patients were reviewed with 83 in group 1and 10 in group 2. Radiologist A suggested high priority colonic examination in 18% and 50% of groups 1 and 2, and Radiologist B in 63% and 90%. There was a statically significant inter-observer difference and also lower accuracy of Radiologist B than Radiologist A in predicting a subsequent 'clean colon' examination.

Conclusion: 

Using an emergency acute CT scan at the time of diagnosis of diverticulitis to predict a clean colon examination for neoplasia is not reliable since there is considerable degree of inter-observer difference between rediologista.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-160756 (URN)10.1111/j.1463-1318.2011.02814.x (DOI)000304994100032 ()21899711 (PubMedID)
Available from: 2011-10-31 Created: 2011-10-31 Last updated: 2017-12-08Bibliographically approved
Arakelian, E., Torkzad, M. R., Bergman, A., Rubertsson, S. & Mahteme, H. (2012). Pulmonary influences on early post-operative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment: a retrospective study. World Journal of Surgical Oncology, 10, 258
Open this publication in new window or tab >>Pulmonary influences on early post-operative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment: a retrospective study
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2012 (English)In: World Journal of Surgical Oncology, ISSN 1477-7819, E-ISSN 1477-7819, Vol. 10, p. 258-Article in journal (Refereed) Published
Abstract [en]

Background: The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a curative treatment option for peritoneal carcinomatosis (PC). There have been few studies on the pulmonary adverse events (AEs) affecting patient recovery after this treatment, thus this study investigated these factors. Methods: Between January 2005 and December 2006, clinical data on all pulmonary AEs and the recovery progress were reviewed for 76 patients with after CRS and HIPEC. Patients with pulmonary interventions (thoracocenthesis and chest tubes) were compared with the non-intervention patients. Two senior radiologists, blinded to the post-operative clinical course, separately graded the occurrence of pulmonary AEs. Results: Of the 76 patients, 6 had needed thoracocentesis and another 6 needed chest tubes. There were no differences in post-operative recovery between the intervention and non-intervention groups. The total number of days on mechanical ventilation, the length of stay in the intensive care unit, total length of hospital stay, tumor burden, and an American Society of Anesthesiologists (ASA) grade of greater than 2 were correlated with the occurrence of atelectasis and pleural effusion. Extensive atelectasis (grade 3 or higher) was seen in six patients, major pleural effusion (grade 3) in seven patients, and signs of heart failure (grade 1-2) in nine patients. Conclusions: Clinical and radiological post-operative pulmonary AEs are common after CRS and HIPEC. However, most of the pulmonary AEs did not affect post-operative recovery.

Keywords
Peritoneal carcinomatosis, CRS, HIPEC, Post-operative recovery, Pulmonary influences, Radiological assessment
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-193642 (URN)10.1186/1477-7819-10-258 (DOI)000313158500001 ()
Available from: 2013-02-05 Created: 2013-02-05 Last updated: 2017-12-06Bibliographically approved
Torkzad, M. R., Wikström, J., Hansen, T., Bergman, A., Bjerner, T. & Ahlström, H. (2012). The Clinical Perspective on Value of 3D, Thin Slice T2-Weighted Images in 3T Pelvic MRI for Tumors. Current Medical Imaging Reviews, 8(2), 76-81(6)
Open this publication in new window or tab >>The Clinical Perspective on Value of 3D, Thin Slice T2-Weighted Images in 3T Pelvic MRI for Tumors
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2012 (English)In: Current Medical Imaging Reviews, ISSN 1573-4056, Vol. 8, no 2, p. 76-81(6)Article in journal (Refereed) Published
Abstract [en]

Pelvic imaging is undergoing rapid changes due to increased use of 3-Tesla (3T) magnetic resonance imaging (3T MRI). One of the advantages of 3T could be the possibility for thin section 3-dimensional (3D) imaging which could improve accuracy and at the same time reduce the need for multi-planar imaging needed for conventional T2 imaging (TSE). In the following text we review the advantages of 3D thin section imaging for assessment of pelvic tumors.

Keywords
MRI, pelvic neoplasms, imaging three-dimensional
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-181181 (URN)10.2174/157340512800672243 (DOI)000310573200002 ()
Available from: 2012-09-18 Created: 2012-09-18 Last updated: 2012-12-11Bibliographically approved
Krause, J., Bergman, A., Graf, W., Nilsson, A. & Mahteme, H. (2012). Ultrasonography findings and tumour quantification in patients with pseudomyxoma peritonei. European Journal of Radiology, 81(4), 648-651
Open this publication in new window or tab >>Ultrasonography findings and tumour quantification in patients with pseudomyxoma peritonei
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2012 (English)In: European Journal of Radiology, ISSN 0720-048X, E-ISSN 1872-7727, Vol. 81, no 4, p. 648-651Article in journal (Refereed) Published
Abstract [en]

Pseudomyxoma peritonei (PMP) is a disease with various clinical presentations and the diagnostic value of ultrasonography (US) is under investigated. The purpose of this study was to identify the most common US finding in PMP and to investigate US sensitivity, specificity, positive and negative predictive value in quantifying tumour burden in different abdomino-pelvic regions in PMP patients. Between February 2006 and December 2008, 54 patients were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) due to PMP. The results from preoperative US examination with and without intravenously administrated contrast (SonoVue) were compared to surgical findings. The mean US peritoneal cancer index (PCI) was 6 (range 0-25) and the surgical PCI was 18 (range 3-27) p<0.0001. The histo-pathological subtypes did not influence the US findings. Ascites, bowel loops adhesions and omental cake were mostly visualised correctly by US. The sensitivity of US in quantification of tumour nodules was 91.5% (range 74-100%) and specificity was 33.8% (range 18-55%). The positive predictive value of US examination in PMP was 22% (range 11-44%) and the negative predictive value was 93% (range 77-100%). US can detect the most common PMP findings (ascites and omental cake). The sensitivity of US to quantify PMP tumour burden in different abdominio-pelvic region was relatively high, however, this imaging tool had low specificity.

Keywords
Peritoneal carcinomatosis, Hyperthermia, Prophylactic strategy, Sugarbaker Protocol/techniques, Mainland China
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-165400 (URN)10.1016/j.ejrad.2011.01.033 (DOI)000301372300051 ()21349674 (PubMedID)
Available from: 2012-01-05 Created: 2012-01-05 Last updated: 2017-12-08Bibliographically approved
Ekman, S., Frödin, J.-E., Harmenberg, J., Bergman, A., Hedlund, Å., Dahg, P., . . . Bergqvist, M. (2011). Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma. Acta Oncologica, 50(3), 441-447
Open this publication in new window or tab >>Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma
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2011 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 50, no 3, p. 441-447Article in journal (Refereed) Published
Abstract [en]

Background. Inhibition of the Insulin-like Growth Factor-1 receptor (IGF-1R) has resulted in extensive anti-tumor effects. Picropdophyllin (PPP, AXL1717) is a small-molecule inhibitor of the IGF-1R without inhibition of closely related receptors including the insulin receptor and has shown extensive effects against a wide range of tumors in animals. PPP is currently tested as an orally administrated single agent treatment in an open-label combined Phase I/II clinical study in advanced cancer patients with solid tumors which progress in spite of several lines of treatment. Patients and methods. The first part (Phase IA) consisted of single day BID dosing every three weeks with consecutive dose escalations. The second part (Phase IB) consists of seven days or longer BID dosing every three weeks, dosing range being 520-700 mg BID. Non-progressing patients could continue treatment within a compassionate use setting. Results and discussion. The present report describes our experience with the four patients with progressive squamous non-small cell lung cancer (NSCLC) that have received treatment with PPP. Despite more than seven months of PPP treatment as third or fourth line treatment, the reported patients did not develop any additional metastases. Furthermore, CT scans as well as (18)FDG-Positron Emission Tomography (PET) scans of the patients demonstrated large central necrotic areas, which may suggest tumor response. At the same time, the study drug is so far well tolerated. The phenomenon of necrosis in the tumors suggestive of tumor response has not been reported before in anti-IGF-1R treatment and will be subject to further studies in the present clinical trial.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-129608 (URN)10.3109/0284186X.2010.499370 (DOI)000288323800017 ()20698809 (PubMedID)
Available from: 2010-08-19 Created: 2010-08-19 Last updated: 2017-12-12Bibliographically approved
Weis, J., Jorulf, H., Bergman, A., Ortiz-Nieto, F., Häggman, M. & Ahlström, H. (2011). MR spectroscopy of the human prostate using surface coil at 3 T: Metabolite ratios, age-dependent effects, and diagnostic possibilities. Journal of Magnetic Resonance Imaging, 34(6), 1277-1284
Open this publication in new window or tab >>MR spectroscopy of the human prostate using surface coil at 3 T: Metabolite ratios, age-dependent effects, and diagnostic possibilities
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2011 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 34, no 6, p. 1277-1284Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

To measure prostate spectra of healthy volunteers using a surface coil, to demonstrate age-dependent effects, and to investigate diagnostic possibilities for prostate cancer detection.

MATERIALS AND METHODS:

Single-voxel and 2D magnetic resonance spectroscopic imaging (MRSI) spectra of 51 healthy volunteers with biopsy-proven prostate carcinoma of 20 patients for comparison were measured and processed using the LCModel. The mean normalized spectra and mean metabolite-to-citrate intensity ratios were computed.

RESULTS:

Metabolite-to-citrate ratios of healthy volunteers were lower in the older group (>51 years) than in the younger group (<45 years). The peripheral zone (PZ) revealed a lower metabolite-to-citrate intensity ratio than the central gland (CG). Age-related differences in metabolite-to-citrate ratio were insignificant in the voxels with predominantly CG tissue, whereas significant differences were found in the PZ. Sensitivity in detecting prostate cancer by single-voxel spectroscopy (SVS) and 2D MRSI was 75% and 80%, respectively.

CONCLUSION:

SVS and 2D MRSI of the prostate at 3 T, using a surface coil, are useful in situations when insertion of the endorectal coil into the rectum is difficult or impossible. Our findings of age-dependent effects may be of importance for the analysis of patient spectra.

Keywords
single-voxel spectroscopy, spectroscopic imaging, prostate cancer, 3 Tesla, LCModel, surface coil
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-160997 (URN)10.1002/jmri.22746 (DOI)000297298800004 ()21954046 (PubMedID)
Available from: 2011-11-04 Created: 2011-11-04 Last updated: 2017-12-08Bibliographically approved
Arakelian, E., Torkzad, M. R., Bergman, A., Rubertsson, S. & Mahteme, H. (2011). Pulmonary influences on early postoperative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment. Anesthesia and Analgesia
Open this publication in new window or tab >>Pulmonary influences on early postoperative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment
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2011 (English)In: Anesthesia and Analgesia, ISSN 0003-2999, E-ISSN 1526-7598Article in journal (Other academic) Submitted
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-159497 (URN)
Available from: 2011-10-03 Created: 2011-10-03 Last updated: 2017-12-08Bibliographically approved
Balleyguier, C., Sala, E., Da Cunha, T., Bergman, A., Brkljacic, B., Danza, F., . . . Kinkel, K. (2011). Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. European Radiology, 21(5), 1102-1110
Open this publication in new window or tab >>Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology
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2011 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 21, no 5, p. 1102-1110Article in journal (Refereed) Published
Abstract [en]

Objective: To design clear guidelines for the staging and follow-up of patients with uterine cervical cancer, and to provide the radiologist with a framework for use in multidisciplinary conferences. Methods: Guidelines for uterine cervical cancer staging and follow-up were defined by the female imaging subcommittee of the ESUR (European Society of Urogenital Radiology) based on the expert consensus of imaging protocols of 11 leading institutions and a critical review of the literature. Results: The results indicated that high field Magnetic Resonance Imaging (MRI) should include at least two T2-weighted sequences in sagittal, axial oblique or coronal oblique orientation (short and long axis of the uterine cervix) of the pelvic content. Axial T1-weighted sequence is useful to detect suspicious pelvic and abdominal lymph nodes, and images from symphysis to the left renal vein are required. The intravenous administration of Gadolinium-chelates is optional but is often required for small lesions (< 2 cm) and for follow-up after treatment. Diffusion-weighted sequences are optional but are recommended to help evaluate lymph nodes and to detect a residual lesion after chemoradiotherapy. Conclusions: Expert consensus and literature review lead to an optimized MRI protocol to stage uterine cervical cancer. MRI is the imaging modality of choice for preoperative staging and follow-up in patients with uterine cervical cancer.

Keywords
Uterus, Cervix, Cervical cancer, Staging, Magnetic resonance (MR)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-152906 (URN)10.1007/s00330-010-1998-x (DOI)000289291100025 ()21063710 (PubMedID)
Available from: 2011-05-03 Created: 2011-05-03 Last updated: 2017-12-11Bibliographically approved
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