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Lafta, M. S., Mwinyi, J., Affatato, O., Rukh, G., Dang, J., Andersson, G. & Schiöth, H. B. (2024). Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology. Frontiers in Neuroscience, 18, Article ID 1340108.
Open this publication in new window or tab >>Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology
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2024 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 18, article id 1340108Article, review/survey (Refereed) Published
Abstract [en]

Increased knowledge about sex differences is important for development of individualized treatments against many diseases as well as understanding behavioral and pathological differences. This review summarizes sex chromosome effects on gene expression, epigenetics, and hormones in relation to the brain. We explore neuroanatomy, neurochemistry, cognition, and brain pathology aiming to explain the current state of the art. While some domains exhibit strong differences, others reveal subtle differences whose overall significance warrants clarification. We hope that the current review increases awareness and serves as a basis for the planning of future studies that consider both sexes equally regarding similarities and differences.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
sex differences, genetics, neuroanatomy, neurochemistry, cognition, pathology
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-524977 (URN)10.3389/fnins.2024.1340108 (DOI)001176090800001 ()38449735 (PubMedID)
Available from: 2024-03-15 Created: 2024-03-15 Last updated: 2024-03-15Bibliographically approved
Myrov, V. O., Polovian, A. I., Kolchanova, S., Galumov, G. K., Schiöth, H. B. & Bozhko, D. V. (2023). Artificial Neural Network (ANN)-Based Pattern Recognition Approach Illustrates a Biphasic Behavioral Effect of Ethanol in Zebrafish: A High-Throughput Method for Animal Locomotor Analysis. Biomedicines, 11(12), Article ID 3215.
Open this publication in new window or tab >>Artificial Neural Network (ANN)-Based Pattern Recognition Approach Illustrates a Biphasic Behavioral Effect of Ethanol in Zebrafish: A High-Throughput Method for Animal Locomotor Analysis
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2023 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 11, no 12, article id 3215Article in journal (Refereed) Published
Abstract [en]

Variations in stress responses between individuals are linked to factors ranging from stress coping styles to the sensitivity of neurotransmitter systems. Many anxiolytic compounds can increase stressor engagement through the modulation of neurotransmitter systems and are used to investigate stress response mechanisms. The effect of such modulation may vary in time depending on concentration or environment, but those effects are hard to dissect because of the slow transition. We investigated the temporal effect of ethanol and found that ethanol-treated individual zebrafish larvae showed altered behavior that is different between drug concentrations and decreases with time. We used an artificial neural network approach with a time-dependent method for analyzing long (90 min) experiments on zebrafish larvae and found that individuals from the 0.5% group begin to show locomotor activity corresponding to the control group starting from the 60th minute. The locomotor activity of individuals from the 2% group after the 80th minute is classified as the activity of individuals from the 1.5% group. Our method shows three clusters of different concentrations in comparison with two clusters, which were obtained with the usage of a statistical approach for analyzing just the speed of fish movements. In addition, we show that such changes are not explained by basic behavior statistics such as speed and are caused by shifts in locomotion patterns.

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
artificial neural networks, ethanol, time-dependent analyses, zebrafish
National Category
Behavioral Sciences Biology Neurosciences
Identifiers
urn:nbn:se:uu:diva-519434 (URN)10.3390/biomedicines11123215 (DOI)001130685600001 ()38137436 (PubMedID)
Available from: 2024-01-08 Created: 2024-01-08 Last updated: 2024-01-23Bibliographically approved
Affatato, O., Dahlén, A., Rukh, G., Schiöth, H. B. & Mwinyi, J. (2023). Assessing volumetric brain differences in migraine and depression patients: a UK Biobank study. BMC Neurology, 23(1), Article ID 284.
Open this publication in new window or tab >>Assessing volumetric brain differences in migraine and depression patients: a UK Biobank study
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2023 (English)In: BMC Neurology, E-ISSN 1471-2377, Vol. 23, no 1, article id 284Article in journal (Refereed) Published
Abstract [en]

Background: Migraine and depression are two of the most common and debilitating conditions. From a clinical perspective, they are mostly prevalent in women and manifest a partial overlapping symptomatology. Despite the high level of comorbidity, previous studies hardly investigated possible common patterns in brain volumetric differences compared to healthy subjects. Therefore, the current study investigates and compares the volumetric difference patterns in sub-cortical regions between participants with migraine or depression in comparison to healthy controls.

Methods: The study included data from 43 930 participants of the large UK Biobank cohort. Using official ICD10 diagnosis, we selected 712 participants with migraine, 1 853 with depression and 23 942 healthy controls. We estimated mean volumetric difference between the groups for the different sub-cortical brain regions using generalized linear regression models, conditioning the model within the levels of BMI, age, sex, ethnical background, diastolic blood pressure, current tobacco smoking, alcohol intake frequency, Assessment Centre, Indices of Multiple Deprivation, comorbidities and total brain volume.

Results: We detected larger overall volume of the caudate (mean difference: 66, 95% CI [-3, 135]) and of the thalamus (mean difference: 103 mm(3), 95% CI [-2, 208]) in migraineurs than healthy controls. We also observed that individuals with depression appear to have also larger overall (mean difference: 47 mm(3), 95% CI [-7, 100]) and gray matter (mean difference: 49 mm(3), 95% CI [2, 95]) putamen volumes than healthy controls, as well as larger amygdala volume (mean difference: 17 mm(3), 95% CI [-7, 40]).

Conclusion: Migraineurs manifested larger overall volumes at the level of the nucleus caudate and of the thalamus, which might imply abnormal pain modulation and increased migraine susceptibility. Larger amygdala and putamen volumes in participants with depression than controls might be due to increased neuronal activity in these regions.

Place, publisher, year, edition, pages
BMC, 2023
Keywords
Migraine, Depression, Structural brain MRI, UK Biobank
National Category
Neurosciences Neurology
Identifiers
urn:nbn:se:uu:diva-509232 (URN)10.1186/s12883-023-03336-x (DOI)001040412700002 ()37507671 (PubMedID)
Available from: 2023-08-22 Created: 2023-08-22 Last updated: 2023-08-22Bibliographically approved
Lagunas-Rangel, F. A., Liao, S., Williams, M. J., Trukhan, V., Fredriksson, R. & Schiöth, H. B. (2023). Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4. Biomedicines, 11(11), Article ID 3032.
Open this publication in new window or tab >>Drosophila as a Rapid Screening Model to Evaluate the Hypoglycemic Effects of Dipeptidyl Peptidase 4 (DPP4) Inhibitors: High Evolutionary Conservation of DPP4
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2023 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 11, no 11, article id 3032Article in journal (Refereed) Published
Abstract [en]

Dipeptidyl peptidase 4 (DPP4) inhibitors, commonly known as gliptins, have been an integral part of the treatment of type 2 diabetes mellitus (T2DM) for several years. Despite their remarkable efficacy in lowering glucose levels and their compatibility with other hypoglycemic drugs, recent studies have revealed adverse effects, prompting the search for improved drugs within this category, which has required the use of animal models to verify the hypoglycemic effects of these compounds. Currently, in many countries the use of mammals is being significantly restricted, as well as cost prohibitive, and alternative in vivo approaches have been encouraged. In this sense, Drosophila has emerged as a promising alternative for several compelling reasons: it is cost-effective, offers high experimental throughput, is genetically manipulable, and allows the assessment of multigenerational effects, among other advantages. In this study, we present evidence that diprotin A, a DPP4 inhibitor, effectively reduces glucose levels in Drosophila hemolymph. This discovery underscores the potential of Drosophila as an initial screening tool for novel compounds directed against DPP4 enzymatic activity.

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
diabetes, alternative animal model, new drugs, glucose levels
National Category
Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-519101 (URN)10.3390/biomedicines11113032 (DOI)001123437400001 ()38002032 (PubMedID)
Funder
Swedish Research Council
Available from: 2024-01-04 Created: 2024-01-04 Last updated: 2024-01-04Bibliographically approved
Rukh, G., de Ruijter, M. & Schiöth, H. B. (2023). Effect of worry, depression, and sensitivity to environmental stress owing to neurotic personality on risk of cardiovascular disease: A Mendelian randomization study. Journal of personality, 91(3), 856-867
Open this publication in new window or tab >>Effect of worry, depression, and sensitivity to environmental stress owing to neurotic personality on risk of cardiovascular disease: A Mendelian randomization study
2023 (English)In: Journal of personality, ISSN 0022-3506, E-ISSN 1467-6494, Vol. 91, no 3, p. 856-867Article in journal (Refereed) Published
Abstract [en]

Objective

This study investigated the putative causal link between neuroticism (using three genetically distinct subclusters namely depressed affect, worry, and sensitivity to environmental stress and adversity [SESA]) and cardiovascular disease (CVD).

Method

A two-sample bi-directional Mendelian randomization (MR) approach was used. Genetic instruments were extracted from publically available GWAS summary statistics.

Results

In forward MR analyses with neuroticism subclusters as exposures, no causal associations between worry or SESA cluster and any of the CVD traits were observed (p > .05 for all). However, a higher risk of having heart failure (odds ratio (95% confidence interval):1.32(1.12 to 1.56); p = .0011) and myocardial infarction (1.47[1.18 to 1.83]; p = 6.3 × 10-4) associated with depressed affect cluster was observed. In reverse MR analyses with CVD traits as exposures, no significant associations were observed (p > .05 for all).

Conclusions

Individuals with high neuroticism who are more susceptible to depressive symptoms are at higher risk for developing heart failure and myocardial infarction and should be more carefully evaluated for CVD risk in clinical settings. These individuals can potentially benefit from interventions aimed at reducing depressive symptoms to decrease CVD risk. There is no evidence to suggest that being sensitive to environmental stressors or being more worried can increase the risk for CVD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
National Category
Neurosciences Psychiatry
Identifiers
urn:nbn:se:uu:diva-500827 (URN)10.1111/jopy.12782 (DOI)000865617400001 ()36165189 (PubMedID)
Funder
Swedish Society for Medical Research (SSMF)Swedish Research CouncilAFA Insurance
Available from: 2023-04-26 Created: 2023-04-26 Last updated: 2023-05-12Bibliographically approved
Moulin, T., Stojanovic, T., Rajesh, R. P., Pareek, T., Donzelli, L., Williams, M. J. & Schiöth, H. B. (2023). Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis. Biomedicines, 11(1), Article ID 192.
Open this publication in new window or tab >>Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis
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2023 (English)In: Biomedicines, E-ISSN 2227-9059, Vol. 11, no 1, article id 192Article in journal (Refereed) Published
Abstract [en]

MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes. Although its effects in rodents are well characterised, little is known about the outcomes of this drug in other organisms. In this study, we characterise the effects of MK-801 on the locomotion, sleep, and negative geotaxis of the fruit fly Drosophila melanogaster. We observed that acute (24 h) and chronic (7 days) administration of MK-801 enhanced negative geotaxis activity in the forced climbing assay for all tested concentrations (0.15 mM, 0.3 mM, and 0.6 mM). Moreover, acute administration, but not chronic, increased the flies' locomotion in a dose-dependent matter. Finally, average sleep duration was not affected by any concentration or administration protocol. Our results indicate that acute MK-801 could be used to model hyperactivity phenotypes in Drosophila melanogaster. Overall, this study provides further evidence that the NMDA receptor system is functionally conserved in flies, suggesting the usefulness of this model to investigate several phenotypes as a complement and replacement of the rodent models within drug discovery.

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
fruit fly, invertebrates, glutamate receptor, dizocilpine, circadian activity, climbing behavior, psychiatric models, translational models
National Category
Pharmacology and Toxicology Neurosciences
Identifiers
urn:nbn:se:uu:diva-497724 (URN)10.3390/biomedicines11010192 (DOI)000916911300001 ()36672700 (PubMedID)
Funder
Swedish Research Council, 2019-01066EU, Horizon 2020, 857394Gunvor och Josef Anérs stiftelse
Available from: 2023-03-07 Created: 2023-03-07 Last updated: 2023-03-07Bibliographically approved
Rabinovitch, A., Koshelev, D., Lagunas-Rangel, F. A., Kosheleva, L., Gavra, T., Schiöth, H. B. & Levit, S. (2023). Efficacy of combination therapy with GABA, a DPP-4i and a PPI as an adjunct to insulin therapy in patients with type 1 diabetes. Frontiers in Endocrinology, 14, Article ID 1171886.
Open this publication in new window or tab >>Efficacy of combination therapy with GABA, a DPP-4i and a PPI as an adjunct to insulin therapy in patients with type 1 diabetes
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2023 (English)In: Frontiers in Endocrinology, E-ISSN 1664-2392, Vol. 14, article id 1171886Article in journal (Refereed) Published
Abstract [en]

Introduction: The purpose of this retrospective clinic chart review study was to determine the potential of a combination therapy (CT) consisting of γ-aminobutyric acid (GABA), a dipeptidyl peptidase-4 inhibitor (DPP-4i), and a proton pump inhibitor (PPI) to improve glycemic control as an adjunct to insulin therapy in patients with type 1 diabetes (T1D).

Research design and methods: Nineteen patients with T1D on insulin therapy were treated with additional CT in oral form. Fasting blood glucose (FBG), HbA1c, insulin dose-adjusted HbA1c (IDA-A1c), daily insulin dose, insulin/weight ratio (IWR), and fasting plasma C-peptide were measured after 26-42 weeks of treatments.

Results: FBG, HbA1c, IDA-A1c, insulin dose and IWR were all significantly decreased while plasma C-peptide was significantly increased by the CT. Treatment outcomes were further analyzed by separation of the 19 patients into two groups. One group started on the CT within 12 months of insulin treatment (early therapy, 10 patients) and another group started on this therapy only after 12 months of insulin treatment (late therapy, 9 patients). FBG, IDA-A1c, insulin dose, and IWR decreased significantly in both the early and late CT groups, however to a better extent in the early therapy group. Moreover, plasma C-peptide increased significantly only in the early therapy group, and 7 of the 10 patients in this group were able to discontinue insulin treatment while maintaining good glycemic control to study end compared with none of the 9 patients in the late therapy group.

Conclusion: These results support the concept that the combination of GABA, a DPP-4i and a PPI as an adjunct to insulin therapy improves glycemic control in patients with T1D, and that the insulin dose required for glycemic control can be reduced or even eliminated in some patients receiving this novel therapy.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
type 1 diabetes, insulin, GABA, DPP-4i, PPI
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-506922 (URN)10.3389/fendo.2023.1171886 (DOI)001002186000001 ()37293502 (PubMedID)
Funder
Swedish Research CouncilNovo Nordisk
Note

De två första författarna delar förstaförfattarskapet

De två sista författarna delar sistaförfattarskapet

Available from: 2023-06-30 Created: 2023-06-30 Last updated: 2024-01-17Bibliographically approved
Bostrom, A. E. D., Jamshidi, E., Manu, D.-M., Kular, L., Schiöth, H. B., Asberg, M. & Jokinen, J. (2023). Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters. Journal of Psychiatric Research, 160, 217-224
Open this publication in new window or tab >>Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters
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2023 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 160, p. 217-224Article in journal (Refereed) Published
Abstract [en]

Background: The ability to accurately estimate risk of suicide deaths on an individual level remains elusive.

Methods: This study reports on a case-control study set-up from a well-characterized cohort of 88 predominantly female suicide attempters (SA), stratified into low- (n = 57) and high-risk groups (n = 31) based on reports of later death by suicide, as well as degree of intent-to-die and lethality of SA method. We perform an unbiased analysis of 12,930 whole-blood derived CpG-sites (Illumina Infinium EPIC BeadChip) previously demonstrated to be more conciliable with brain-derived variations. The candidate site was validated by pyrosequencing. External replication was performed in (1) relation to age at index suicide attempt in 97 women with emotionally unstable personality disorder (whole-blood) and (2) death by suicide in a mixed group of 183 prefrontal-cortex (PFC) derived samples who died by suicide or from non-psychiatric etiologies.

Results: CYP2D6-coupled CpG-site cg07016288 was hypomethylated in severe suicidal behavior (p < 10E-06). Results were validated by pyrosequencing (p < 0.01). Replication analyses demonstrate hypomethylation of cg07016288 in relation to age at index SA in females (p < 0.05) and hypermethylation in PFC of male suicide completers (p < 0.05). Limitations: Genotyping of CYP2D6 was not performed and CpG-site associations to gene expression were not explored.

Conclusions: CYP2D6-coupled epigenetic markers are hypomethylated in females in dependency of features known to confer increased risk of suicide deaths and hypermethylated in PFC of male suicide completers. Further elucidating the role of CYP2D6 in severe suicidality or suicide deaths hold promise to deduce clinically meaningful results.

Place, publisher, year, edition, pages
ElsevierElsevier BV, 2023
Keywords
Suicide, Suicide prevention, DNA methylation, Psychiatry, cg07016288
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-500011 (URN)10.1016/j.jpsychires.2023.02.025 (DOI)000949417500001 ()36857986 (PubMedID)
Funder
Swedish Research Council, 5454Swedish Research Council, K2009-61P-21304-04-4Swedish Research Council, K2009-61X-21305-01-1
Available from: 2023-04-19 Created: 2023-04-19 Last updated: 2024-01-15Bibliographically approved
Mälarstig, A., Grassmann, F., Dahl, L., Dimitriou, M., McLeod, D., Gabrielson, M., . . . Hedman, Å. K. (2023). Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation. Nature Communications, 14(1), Article ID 7680.
Open this publication in new window or tab >>Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
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2023 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 14, no 1, article id 7680Article in journal (Refereed) Published
Abstract [en]

Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association between protein levels, clinical characteristics, and gene variants, and to identify proteins with a causal role in breast cancer. We present 812 cis-acting protein quantitative trait loci for 737 proteins which are used as instruments in Mendelian randomisation analyses of breast cancer risk. Of those, we present five proteins (CD160, DNPH1, LAYN, LRRC37A2 and TLR1) that show a potential causal role in breast cancer risk with confirmatory results in independent cohorts. Our study suggests that these proteins should be further explored as biomarkers and potential drug targets in breast cancer.

Place, publisher, year, edition, pages
Springer Nature, 2023
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-519045 (URN)10.1038/s41467-023-43485-8 (DOI)001109528700001 ()37996402 (PubMedID)
Funder
Swedish Research Council, 2022-00584Swedish Cancer Society, 22 2207Swedish Cancer Society, 19 0267Swedish Cancer Society, 20 0990Stockholm County Council, FoUI-954555Stockholm County Council, FoUI-978540Stockholm County Council, 20200102The Karolinska Institutet's Research Foundation, 2018-02146Pfizer AB
Available from: 2024-01-02 Created: 2024-01-02 Last updated: 2024-01-03Bibliographically approved
Schiöth, H. B., Donzelli, L., Arvidsson, N., Williams, M. J. & Moulin, T. (2023). Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster. Biology, 12(4), Article ID 635.
Open this publication in new window or tab >>Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
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2023 (English)In: Biology, E-ISSN 2079-7737, Vol. 12, no 4, article id 635Article in journal (Refereed) Published
Abstract [en]

Simple Summary In our study, we looked at a behavior called prepulse inhibition (PPI) in Drosophila melanogaster, commonly known as the fruit fly. For many animals, the sudden presentation of strong sensorial stimuli can induce a defensive response or motor reflex. PPI is a phenomenon where a small stimulus, named "prepulse," is presented shortly before a larger stimulus, so the larger stimulus induces a weaker response than it normally would. This behavior is seen in many different types of animals and is used to study conditions such as anxiety and schizophrenia. For this study, the chosen stimulus is the sudden presentation of one-second darkness, or lights-off, shown to evoke an immediate locomotion response in Drosophila. Our research found that PPI can also be seen in adult flies, which has not been reported before. Additionally, we confirmed our results by showing that a drug that affects an important brain component, called the NMDA receptor, can change PPI in flies. We suggest that studying this behavior in fruit flies could help us understand how it works in other animals, including humans. Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.

Place, publisher, year, edition, pages
MDPIMDPI AG, 2023
Keywords
prepulse inhibition (PPI), Drosophila melanogaster, escape response, startle, anxiety, schizophrenia, invertebrates, sensorimotor gating, dizocilpine
National Category
Pharmacology and Toxicology Zoology
Identifiers
urn:nbn:se:uu:diva-501961 (URN)10.3390/biology12040635 (DOI)000978888500001 ()37106835 (PubMedID)
Funder
Swedish Research Council, 2019-01066Royal Physiographic Society in LundEU, Horizon 2020, 857394
Available from: 2023-05-22 Created: 2023-05-22 Last updated: 2024-01-15Bibliographically approved
Projects
Central regulation of food intake [2008-03341_VR]; Uppsala UniversityCentral regulation of food intake and reward [2010-02696_VR]; Uppsala UniversityThe evolutionary mechanism that shaped large gene families among membrane bound proteins [2010-04819_VR]; Uppsala UniversityCentral regulation of food intake and reward [2013-02892_VR]; Uppsala UniversityDevelopment of a replacement model to determine short and long term effects of environmental toxin mixtures using Drosophila [2014-02812_VR]; Uppsala UniversityCentral regulation of food intake and reward; Molecular mechanisms and human pathologies [2016-01088_VR]; Uppsala UniversityDevelopment of a Drosophila replacement model to determine short and long term effects of environmental toxin mixtures [2018-03238_VR]; Uppsala UniversityPredictive model of the synergistic effects of environmental pollutant mixtures [2019-01793_VR]; Uppsala UniversityThe molecular mechanisms underlying the effects of statins and the role of HMGCR in endocrine, neuronal and muscular functions [2019-01066_VR]; Uppsala University
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-7112-0921

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