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Publications (10 of 93) Show all publications
Rezaei, F., Carlsson, D. O., Hedin Dahlstrom, J., Lindh, J. & Johansson, S. (2025). Near-collector electroprinting of cellulose acetate structures with large specific surface per volume. Micro and Nano Engineering, 27, Article ID 100299.
Open this publication in new window or tab >>Near-collector electroprinting of cellulose acetate structures with large specific surface per volume
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2025 (English)In: Micro and Nano Engineering, E-ISSN 2590-0072, Vol. 27, article id 100299Article in journal (Refereed) Published
Abstract [en]

This study focuses on the fabrication and analysis of 3D-printed high-detail resolution cellulose acetate (CA) structures, particularly examining their specific surface area per volume (Sv). While electrospinning is a widely used technique for creating nanofiber membranes with high Sv, which is advantageous for applications like chromatography, the performance could be further improved by precisely controlling fiber placement. To further develop membranes, this research explores the use of electroprinting with small distances between nozzle and collector, here named near-collector electroprinting, to create 3D structures. By optimizing printing parameters, in particular the reduction of the nozzle-to-collector distance, 3D structures with precise fiber placement within a few micrometers were fabricated. The specific surface area per volume was calculated for both 3D-printed and electrospun filters. Results showed that 3D-printed structures with a 5 μm pitch achieved a Sv similar to electrospun filters.

Incorporating polyethyleneimine (PEI) in the CA ink enabled the 3D-printed structures to gain ion binding capacity which was further investigated. This ion-exchange ability which integrated into the printing step, eliminating the need for a separate post-modification process in bio-separation applications. By switching the substrate voltage from positive to negative, relative to the grounded nozzle, the printed fiber diameter decreased substantially for the CA ink with PEI. The Sv for near-collector electroprinted fibers of this material could therefore potentially be higher than that of electrospun membranes, provided that an order of magnitude higher printing speed, than presently possible can be used. These findings suggest that near-collector electroprinted CA structures offer potential improvements in membrane design and performance, making them a promising alternative to traditional electrospun membranes for bio-separation applications.

Place, publisher, year, edition, pages
Elsevier, 2025
National Category
Materials Engineering
Identifiers
urn:nbn:se:uu:diva-552494 (URN)10.1016/j.mne.2025.100299 (DOI)001491237700001 ()2-s2.0-105004644706 (Scopus ID)
Available from: 2025-03-15 Created: 2025-03-15 Last updated: 2025-06-03Bibliographically approved
Autenrieth, J., Hedbom, D., Strömme, M., Kipping, T., Lindh, J. & Quodbach, J. (2025). Selective laser sintering of distinct drug and polymer layers as a novel manufacturing strategy for individually dosed tablets. International Journal of Pharmaceutics: X, Article ID 100338.
Open this publication in new window or tab >>Selective laser sintering of distinct drug and polymer layers as a novel manufacturing strategy for individually dosed tablets
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2025 (English)In: International Journal of Pharmaceutics: X, E-ISSN 2590-1567, article id 100338Article in journal (Refereed) Epub ahead of print
Abstract [en]

Selective Laser Sintering (SLS) is an emerging additive manufacturing technology with potential for the production of personalized pharmaceuticals. In this study, we investigated a novel simplified formulation approach in SLS-based manufacturing of individually dosed, multi-layered tablets with distinct layers of pure active pharmaceutical ingredient (API) and excipient. Indomethacin (IND) was chosen as the model API, and polyvinyl alcohol (PVA) served as the excipient. Unlike conventional methods requiring powder blending, this approach utilizes separate powder tanks for IND and PVA, enabling direct printing of alternating layers in a single-step procedure. We successfully fabricated tablets with controlled IND doses by varying the number of IND layers, maintaining consistent printing parameters across different compositions and confirming the API’s chemical stability in the product. Since SLS is conventionally used for thermoplastic substances, the successful sintering of pure IND layers was a key achievement in the study, as this crystalline API is typically not printable separately. Energy dispersive X-ray spectroscopy (EDS) demonstrated the successful formation of distinct API and excipient layers. Differential scanning calorimetry (DSC) characterization revealed that the sintering process partially amorphized IND, which may enhance dissolution and bioavailability. Dissolution testing indicated that the printed tablets exhibited improved dissolution rates compared to raw IND powder. The study successfully demonstrated the possibility of SLS-based production for personalized dosing by omitting powder blending steps. The ability to create individualized dosages with minimal excipients and simplified processing represents a step toward further investigation of SLS for clinical settings, including hospital and pharmacy-based drug production.

Keywords
3D-printing, Personalized medicine, Pharmaceutical technology, Individual dosing
National Category
Nanotechnology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-557052 (URN)10.1016/j.ijpx.2025.100338 (DOI)
Available from: 2025-05-21 Created: 2025-05-21 Last updated: 2025-05-22
Kooijman, W., Levine, V., Kok, R. J., Lindh, J. & Quodbach, J. (2024). Ageing of pharmaceutical formulations during selective laser sintering 3D printing. In: 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology: . Paper presented at 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna, Austria.. Vienna
Open this publication in new window or tab >>Ageing of pharmaceutical formulations during selective laser sintering 3D printing
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2024 (English)In: 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienna, 2024Conference paper, Poster (with or without abstract) (Refereed)
Place, publisher, year, edition, pages
Vienna: , 2024
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-526499 (URN)
Conference
14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna, Austria.
Available from: 2024-04-11 Created: 2024-04-11 Last updated: 2024-04-11
Iurchenkova, A. A., Tammela, P., Wang, Z., Strömme, M., Nyholm, L. & Lindh, J. (2024). CO2-laser carbonization of polypyrrole/nanocellulose free-standing film for energy storage applications. In: RSC (Ed.), RCS Poster Conference 2024: . Paper presented at RCS Poster Conference 2024. 5-6th March 2024 online.. don: Royal Society of Chemistry
Open this publication in new window or tab >>CO2-laser carbonization of polypyrrole/nanocellulose free-standing film for energy storage applications
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2024 (English)In: RCS Poster Conference 2024 / [ed] RSC, don: Royal Society of Chemistry, 2024Conference paper, Poster (with or without abstract) (Refereed)
Place, publisher, year, edition, pages
don: Royal Society of Chemistry, 2024
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-524623 (URN)
Conference
RCS Poster Conference 2024. 5-6th March 2024 online.
Available from: 2024-03-08 Created: 2024-03-08 Last updated: 2024-03-08
Frasca, S., Katsiotis, C. S., Henrik-Klemens, Å., Larsson, A., Strömme, M., Lindh, J., . . . Gising, J. (2024). Compatibility of Kraft Lignin and Phenol-Organosolv Lignin with PLA in 3D Printing and Assessment of Mechanical Recycling. ACS Applied Polymer Materials, 6(22), 13574-13584
Open this publication in new window or tab >>Compatibility of Kraft Lignin and Phenol-Organosolv Lignin with PLA in 3D Printing and Assessment of Mechanical Recycling
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2024 (English)In: ACS Applied Polymer Materials, E-ISSN 2637-6105, Vol. 6, no 22, p. 13574-13584Article in journal (Refereed) Published
Abstract [en]

Lignin is an aromatic biomacromolecule with many promising properties that can be beneficial to polymer blends. The main objective of this work was to investigate the processability, compatibility, and recyclability of lignin blends with poly(lactic acid). Two different commercial kraft lignins and a phenolated organosolv lignin were blended with poly(lactic acid) at various weight percentages, targeting high lignin content (30, 50, and 70 wt %). Obtained blends were used in additive manufacturing via fused deposition modeling. All obtained materials were thoroughly characterized by tensile tests, thermogravimetric analysis, differential scanning calorimetry, and 31P NMR. The recyclability of the polymer blend materials was evaluated by re-extruding them up to four times, and their printability was also assessed. The results showed that the material retained its mechanical properties relatively well for up to three cycles after which its tensile strength decreased by 30%. Phenolated organosolv lignin exhibited better printability across a broader range of lignin content compared to kraft lignin analogs while maintaining similar thermal and mechanical properties.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2024
Keywords
bio-based materials, recycling, polylactic acid, lignin, blends
National Category
Nano Technology
Identifiers
urn:nbn:se:uu:diva-536440 (URN)10.1021/acsapm.4c02208 (DOI)001345565000001 ()2-s2.0-85208407204 (Scopus ID)
Available from: 2024-08-19 Created: 2024-08-19 Last updated: 2025-03-06Bibliographically approved
Levine, V., Katsiotis, C. S., Strömme, M., Quodbach, J. & Lindh, J. (2024). Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets. Frontiers in Drug Delivery, 4, Article ID 1358336.
Open this publication in new window or tab >>Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets
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2024 (English)In: Frontiers in Drug Delivery, ISSN 2674-0850, Vol. 4, article id 1358336Article in journal (Refereed) Published
Abstract [en]

Selective Laser Sintering (SLS) has the potential to offer a more accurate alternative to current-practice manipulation of oral dosage forms for pediatric, geriatric, and dysphagia-suffering patient groups. In order to create the best possible dosage forms for these patient groups, an in-depth look into how a dosage forms geometry impacts the overall properties is essential. In this study, the impact of geometry on SLS manufactured oral dosage forms on the tablet’s microstructure, actual-to-theoretical volume, mass deviation, disintegration, and dissolution was investigated. Three different shapes; cylinder, hollow cylinder, and conical frustum with similar surface area (SA), as well as three cylinders with different diameters, were investigated. The results indicate that the geometry has an impact on the mass uniformity, resultant volume, disintegration, and dissolution properties of the tablets. The mass uniformity analysis of the tablets provided the most variation between tablets of different sizes, with more uniformity for tablets with similar SA-to-volume ratio (SA/V). When examining the actual-to-theoretical volume of the tablets, a greater variance between the actual and theoretical volumes for shapes with higher overall SA was observed. The values found are approximately 1.05 for the three differently sized cylinders, 1.23 for the conical frustum, and 1.44 for the hollow cylinder, following this trend. Disintegration data supported a link between SA/V and average disintegration time, observed with the tablet of the highest SA/V disintegrating in 12 s and the tablet with the lowest SA/V disintegrating in 58 s. Dissolution results also indicated a strong dependence on SA/V. Hence, when novel ways to produce oral dosage form tablets become available by additive manufacturing, such as SLS, both geometry and SA/V must be taken into consideration in the tablet design process to ensure appropriate release kinetics and dosing standards.

National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-524625 (URN)10.3389/fddev.2024.1358336 (DOI)
Available from: 2024-03-08 Created: 2024-03-08 Last updated: 2025-03-13
Rezaei, F., Carlsson, D. O., Hedin Dahlström, J., Lindh, J. & Johansson, S. (2024). High detail resolution cellulose structures through electroprinting. Scientific Reports, 14(1), Article ID 27638.
Open this publication in new window or tab >>High detail resolution cellulose structures through electroprinting
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2024 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, no 1, article id 27638Article in journal (Refereed) Published
Abstract [en]

Electrospinning is a technique used to fabricate polymer fibers in micro- and nanoscales. Due to the large distance between the nozzle and collector, there is a limited positioning accuracy of electrospun fibers. To enhance the possibility of fabricating structures with micrometer placement, an electroprinting technique has been developed. By reducing the distance between the nozzle and the collector it is demonstrated that it is possible to get an improved control over fiber positioning which gives a possibility to fabricate designed 3D structures at the micron scale. In this study, cellulose acetate (CA) has been selected as a biomaterial to advance the 3D printing of membranes with possible use in separation applications. Various parameters, such as CA concentration and molecular weight, printing speed, printing pattern, applied voltage, etc. are evaluated with respect to printing control. Results indicate that by optimizing the printing parameters it is possible to print structures with inter- fiber distances down to 3 mu m and fiber diameters at a sub-mu m scale. This electroprinting development is promising for the fabrication of customized separation membranes. However, printing speed still remains a challenge.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
High-resolution 3D printing, Electroprinting, Cellulose acetate, Additive manufacturing
National Category
Paper, Pulp and Fiber Technology Other Engineering and Technologies
Identifiers
urn:nbn:se:uu:diva-544250 (URN)10.1038/s41598-024-78526-9 (DOI)001354064300030 ()39532994 (PubMedID)2-s2.0-85209476472 (Scopus ID)
Funder
Vinnova, 2019-00029
Available from: 2024-12-03 Created: 2024-12-03 Last updated: 2025-04-11Bibliographically approved
Strömme, M., Gising, J., Cheung, O. & Lindh, J. (2024). Hållbar materialutveckling med hjälp av avancerad teknologi öppnar möjligheter till helt nya innovationer. In: Trafikverket (Ed.), FOI-dagen: innovationer för ett effektivare och hållbart infrastrukturunderhåll 2024: . Paper presented at FOI-dagen: innovationer för ett effektivare och hållbart infrastrukturunderhåll 2024. Trafikverket & InfraSweden. Stockholm 29/5 2024.. Stockholm: Trafikverket
Open this publication in new window or tab >>Hållbar materialutveckling med hjälp av avancerad teknologi öppnar möjligheter till helt nya innovationer
2024 (Swedish)In: FOI-dagen: innovationer för ett effektivare och hållbart infrastrukturunderhåll 2024 / [ed] Trafikverket, Stockholm: Trafikverket , 2024Conference paper, Oral presentation with published abstract (Refereed)
Place, publisher, year, edition, pages
Stockholm: Trafikverket, 2024
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-529661 (URN)
Conference
FOI-dagen: innovationer för ett effektivare och hållbart infrastrukturunderhåll 2024. Trafikverket & InfraSweden. Stockholm 29/5 2024.
Available from: 2024-05-29 Created: 2024-05-29 Last updated: 2024-05-29
Tammela, P., Iurchenkova, A. A., Wang, Z., Strömme, M., Nyholm, L. & Lindh, J. (2024). Laser irradiation of photothermal precursors – a novel approach to produce carbon materials for supercapacitors. ChemSusChem, 17(11), 1-11, Article ID e20230.
Open this publication in new window or tab >>Laser irradiation of photothermal precursors – a novel approach to produce carbon materials for supercapacitors
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2024 (English)In: ChemSusChem, ISSN 1864-5631, E-ISSN 1864-564X, Vol. 17, no 11, p. 1-11, article id e20230Article in journal (Refereed) Published
Abstract [en]

A wide array of carbon materials finds extensive utility across various industrial applications today. Nonetheless, the production processes for these materials continue to entail elevated temperatures, necessitate the use of inert atmospheres, and often involve the handling of aggressive and toxic chemicals. The prevalent method for large-scale carbon material production, namely the pyrolysis of waste biomass and polymers, typically unfolds within the temperature range of 500–700 °C under a nitrogen (N2) atmosphere. Unfortunately, this approach suffers from significant energy inefficiency due to substantial heat loss over extended processing durations. In this work, we propose an interesting alternative: the carbonization of photothermal nanocellulose/polypyrrole composite films through CO2 laser irradiation in the presence of air. This innovative technique offers a swift and energy-efficient means of preparing carbon materials. The unique interaction between nanocellulose and polypyrrole imparts the film with sufficient stability to retain its structural integrity post-carbonization. This breakthrough opens up new avenues for producing binder-free electrodes using a rapid and straightforward approach. Furthermore, the irradiated film demonstrates specific and areal capacitances of 159 F g−1 and 62 μF cm−2, respectively, when immersed in a 2 M NaOH electrolyte. These values significantly surpass those achieved by current commercial activated carbons. Together, these attributes render CO2-laser carbonization an environmentally sustainable and ecologically friendly method for carbon material production.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
urn:nbn:se:uu:diva-524624 (URN)10.1002/cssc.202301471 (DOI)001164389000001 ()2-s2.0-85185286990 (Scopus ID)
Funder
Swedish Energy Agency
Available from: 2024-03-08 Created: 2024-03-08 Last updated: 2025-02-10Bibliographically approved
Levine, V. R., Paulsson, M., Strömme, M., Quodbach, J. & Lindh, J. (2024). Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context. International Journal of Pharmaceutics: X, 8, Article ID 100277.
Open this publication in new window or tab >>Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
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2024 (English)In: International Journal of Pharmaceutics: X, E-ISSN 2590-1567, Vol. 8, article id 100277Article in journal (Refereed) Published
Abstract [en]

Pharmacies are currently unable to stock proper oral dosage forms for pediatric populations. This leads to manipulation of medications or the need to compound specialized medications, which can be a time-consuming process. Using Semisolid Extrusion (SSE) additive manufacturing (AM), specialized medications can be produced in an expedited process from off-the shelf medication in a hospital or outpatient pharmacy setting. In this study, tablets with a desired dose of 5 mg of metoprolol tartrate derived from commercial Seloken™ 50 mg tablets were 3D printed in a hospital setting. Validation testing was done on five batches, highlighting tablets with a high uniformity in mass and dimension, drug content, acceptable microbial assays, and prolonged release during in-vitro analysis. The average drug content found for the tablets was within ±6% of 5 mg for all batches produced. Comparisons were done between the SSE tablets and capsules produced in an external compounding facility, highlighting several positive aspects of SSE-produced tablets beyond simply shortening the production timeline. The SSE tablets printed in this study are characterized by their smaller size, enhanced prolonged release properties, and more uniform drug content across the tested samples. Additionally, interviews with pharmaceutical professionals were conducted to determine the positive aspects of SSE and further improvements to bring this technique as seamlessly as possible into the pharmacy. This study underscores the feasibility of employing SSE in the production of specialized medications within a hospital environment. Furthermore, it highlights the methodological advantages SSE offers over existing production standards, demonstrating its potential to improve pharmaceutical manufacturing in healthcare settings.

Place, publisher, year, edition, pages
Elsevier, 2024
National Category
Social and Clinical Pharmacy Materials Engineering
Identifiers
urn:nbn:se:uu:diva-536659 (URN)10.1016/j.ijpx.2024.100277 (DOI)001301499900001 ()
Available from: 2024-08-21 Created: 2024-08-21 Last updated: 2024-09-11Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-5196-4115

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