Open this publication in new window or tab >>Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
Lund Univ, Dept Clin Sci, Malm, Sweden.
Linkoping Univ, Dept Clin Physiol, Linkoping, Sweden;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
Lund Univ, Dept Clin Sci Malmo, Lund, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, Stockholm, Sweden.
Umea Univ, Unit Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
Umea Univ, Unit Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Occupat & Environm Med, Gothenburg, Sweden.
Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Med, Wallenberg Lab,Dept Mol & Clin Med, Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Karolinska Inst, Ctr Mol Med, Resp Med Unit, Dept Med, Stockholm, Sweden;Karolinska Inst, Dept Med Solna, Resp Med Unit, Stockholm, Sweden;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.
Karolinska Inst, Dept Med Solna, Resp Med Unit, Stockholm, Sweden;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.
Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
Umea Univ, Unit Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
Lund Univ, Skane Univ Hosp, Dept Resp Med & Allergol, Malmo, Sweden.
Sahlgrens Univ Hosp, Dept Occupat & Environm, Gothenburg, Sweden.
Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
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2019 (English)In: Thorax, ISSN 0040-6376, E-ISSN 1468-3296, Vol. 74, no 10, p. 958-964Article in journal (Refereed) Published
Abstract [en]
Introduction Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.
Methods This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.
Results We included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.
Conclusion Breathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.
Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP, 2019
Keywords
dyspnoea, sex, weight, lung function, lung volume
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:uu:diva-395787 (URN)10.1136/thoraxjnl-2019-213349 (DOI)000487508000008 ()31434752 (PubMedID)
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaSwedish Heart Lung FoundationSwedish Society of Medicine
2019-10-282019-10-282019-12-19Bibliographically approved