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Marek, K., Wanhainen, A., Tegler, G., Hansen, T. & Mani, K. (2023). Longitudinal Assessment of Inflammatory Activity in Acute Type B Aortic Dissection with Integrated Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging. European Journal of Vascular and Endovascular Surgery, 66(3), 323-331
Open this publication in new window or tab >>Longitudinal Assessment of Inflammatory Activity in Acute Type B Aortic Dissection with Integrated Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging
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2023 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 66, no 3, p. 323-331Article in journal (Refereed) Published
Abstract [en]

Objective: The significance of the inflammatory response in the natural course of acute type B aortic dissection (ATBAD) is unknown. The aim was to characterise inflammation and its transformation over time in ATBAD using F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) with contrast enhanced magnetic resonance imaging (MRI).

Methods: Ten patients underwent FDG-PET/MRI within two weeks of ATBAD (acute phase), three to four months (subacute phase), nine to 12 months (early chronic phase), and 21 to 24 months (late chronic phase) after ATBAD. Target background ratios (TBRs) were measured in the ascending aorta, aortic arch, and descending aorta. MRI inflammatory markers were assessed in the descending aorta.

Results: Ten patients were included: median age 69 years, median clinical follow up 32 months. In the acute phase there was increased FDG uptake in the descending aorta (maximum TBR 5.8, SD [standard deviation] 1.3) compared with the ascending aorta (TBR 3.3, SD 0.8, p < .010) and arch (TBR 4.2, SD 0.6, p = .010). The maximum TBR of the descending aorta decreased from the acute to subacute phase (TBR 3.5, SD 0.6, p = .010) and further to the early chronic phase (TBR 2.9, SD 0.4, p = .030) but was stable thereafter. The acute phase maximum TBR in the ascending aorta (TBR 3.3) and arch (TBR 4.2) decreased to the subacute phase (ascending: TBR 2.8, SD 0.6, p = .020; arch: TBR 2.7, SD 0.4, p = .010) and was stable thereafter. Four patients underwent surgical aortic repair (three for aortic dilatation at one, five, and 28 months and one for visceral ischaemia at three weeks). MRI signs of inflammation were present in all surgically treated patients vs. two of six of medically treated patients (p= .048).

Conclusion: ATBAD is associated with increased FDG uptake in the acute phase primarily in the descending aorta, but also involving the aortic arch and ascending aorta, indicating an inflammatory response in the whole aorta. Inflammation subsides early in the ascending aorta and arch (three months), whereas it stabilised later in the descending aorta (nine to 12 months). MRI signs of inflammation were more frequent in patients who later needed surgical treatment and merit further investigation.

Place, publisher, year, edition, pages
Elsevier, 2023
National Category
Cardiac and Cardiovascular Systems Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-514056 (URN)10.1016/j.ejvs.2023.05.039 (DOI)001073917700001 ()37247689 (PubMedID)
Funder
Swedish Heart Lung Foundation
Available from: 2023-10-17 Created: 2023-10-17 Last updated: 2023-10-17Bibliographically approved
Perchiazzi, G., Larina, A., Hansen, T., Frithiof, R., Hultström, M., Lipcsey, M. & Pellegrini, M. (2022). Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients. Critical Care, 26, Article ID 328.
Open this publication in new window or tab >>Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients
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2022 (English)In: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 26, article id 328Article in journal (Refereed) Published
Abstract [en]

Background: Steroids have been shown to reduce inflammation, hypoxic pulmonary vasoconstriction (HPV) and lung edema. Based on evidence from clinical trials, steroids are widely used in severe COVID-19. However, the effects of steroids on pulmonary gas volume and blood volume in this group of patients are unexplored.

Objective: Profiting by dual-energy computed tomography (DECT), we investigated the relationship between the use of steroids in COVID-19 and distribution of blood volume as an index of impaired HPV. We also investigated whether the use of steroids influences lung weight, as index of lung edema, and how it affects gas distribution.

Methods: Severe COVID-19 patients included in a single-center prospective observational study at the intensive care unit at Uppsala University Hospital who had undergone DECT were enrolled in the current study. Patients' cohort was divided into two groups depending on the administration of steroids. From each patient's DECT, 20 gas volume maps and the corresponding 20 blood volume maps, evenly distributed along the cranial-caudal axis, were analyzed. As a proxy for HPV, pulmonary blood volume distribution was analyzed in both the whole lung and the hypoinflated areas. Total lung weight, index of lung edema, was estimated.

Results: Sixty patients were analyzed, whereof 43 received steroids. Patients not exposed to steroids showed a more extensive non-perfused area (19% vs 13%, p < 0.01) and less homogeneous pulmonary blood volume of hypoinflated areas (kurtosis: 1.91 vs 2.69, p < 0.01), suggesting a preserved HPV compared to patients treated with steroids. Moreover, patients exposed to steroids showed a significantly lower lung weight (953 gr vs 1140 gr, p = 0.01). A reduction in alveolar-arterial difference of oxygen followed the treatment with steroids (322 +/- 106 mmHg at admission vs 267 +/- 99 mmHg at DECT, p = 0.04).

Conclusions The use of steroids might cause impaired HPV and might reduce lung edema in severe COVID-19. This is consistent with previous findings in other diseases. Moreover, a reduced lung weight, as index of decreased lung edema, and a more homogeneous distribution of gas within the lung were shown in patients treated with steroids. Trial registration: Clinical Trials ID: NCT04316884, Registered March 13, 2020.

Place, publisher, year, edition, pages
Springer Nature, 2022
Keywords
COVID-19, Dual-energy CT, Steroids, Hypoxic pulmonary vasoconstriction
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-487890 (URN)10.1186/s13054-022-04200-z (DOI)000871965600001 ()36284360 (PubMedID)
Funder
Knut and Alice Wallenberg Foundation, KAW 2020.0182Knut and Alice Wallenberg Foundation, KAW 2020.0241Swedish Research Council, 2014-02569Swedish Research Council, 2014-07606Swedish Research Council, 2018-02438Swedish Heart Lung Foundation, 20200877Swedish Heart Lung Foundation, 20200825Swedish Heart Lung Foundation, 20210089Swedish Heart Lung Foundation, 2019-0639Swedish Heart Lung Foundation, 2019-0637Swedish Society of Medicine, SLS-959793Swedish Society for Medical Research (SSMF), 463402221
Available from: 2022-11-14 Created: 2022-11-14 Last updated: 2023-10-19Bibliographically approved
Emilsson, Ö. I., Dessle, A., Johansson, H., Adeli, S., Malinovschi, A., Eloranta, M.-L. & Hansen, T. (2022). Different chest HRCT scan protocols change the extent of ground glass opacities. BMC Pulmonary Medicine, 22(1), Article ID 430.
Open this publication in new window or tab >>Different chest HRCT scan protocols change the extent of ground glass opacities
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2022 (English)In: BMC Pulmonary Medicine, E-ISSN 1471-2466, Vol. 22, no 1, article id 430Article in journal (Refereed) Published
Abstract [en]

Background

Ground glass opacity (GGO) is the main HRCT feature representing alveolitis in systemic sclerosis-associated interstitial lung disease (SSc-ILD), but may also represent other conditions such as atelectasis or edema. It is unclear how much this is affected by the HRCT scan protocol used. We aimed to compare the performance of three different HRCT protocols to evaluate the degree of SSc-ILD related changes.

Methods

Eleven patients with SSc underwent chest HRCT scan by three different protocols: First, a supine scan after lying down for 15 minutes, then two scans in alternating order: A prone position scan, and a supine position scan after performing 10 deep breaths using a positive expiratory pressure (PEP) device. The HRCT scans were evaluated by the Warrick score system for ILD-related findings.

Results

The three HRCT protocols were compared and resulted in different mean (95% CI) Warrick scores: 9.4 (5.3–13.4) in supine after rest; 7.5 (95% CI 3.8–11.1) in prone and 7.6 (95% CI 4.2–11.1) in supine after PEP. When comparing supine after rest to prone and supine after PEP, the latter two scans had a significantly lower score (p = 0.001 for both comparisons). In all cases, only sub-scores for ground glass opacities differed, while sub-scores for fibrosis-related changes did not change.

Conclusions

Different HRCT scan protocols significantly altered the Warrick severity score for SSc-ILD findings, primarily because of changes in ground glass opacities. These differences may be clinically meaningful.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-489937 (URN)10.1186/s12890-022-02212-7 (DOI)000886739300001 ()36404311 (PubMedID)
Funder
Uppsala University
Available from: 2022-12-06 Created: 2022-12-06 Last updated: 2024-01-17Bibliographically approved
Pellegrini, M., Larina, A., Mourtos, E., Frithiof, R., Lipcsey, M., Hultström, M., . . . Perchiazzi, G. (2021). A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography. Critical Care, 25(1), Article ID 276.
Open this publication in new window or tab >>A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography
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2021 (English)In: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 25, no 1, article id 276Article in journal (Refereed) Published
Abstract [en]

BackgroundTypical features differentiate COVID-19-associated lung injury from acute respiratory distress syndrome. The clinical role of chest computed tomography (CT) in describing the progression of COVID-19-associated lung injury remains to be clarified. We investigated in COVID-19 patients the regional distribution of lung injury and the influence of clinical and laboratory features on its progression.MethodsThis was a prospective study. For each CT, twenty images, evenly spaced along the cranio-caudal axis, were selected. For regional analysis, each CT image was divided into three concentric subpleural regions of interest and four quadrants. Hyper-, normally, hypo- and non-inflated lung compartments were defined. Nonparametric tests were used for hypothesis testing (alpha =0.05). Spearman correlation test was used to detect correlations between lung compartments and clinical features.ResultsTwenty-three out of 111 recruited patients were eligible for further analysis. Five hundred-sixty CT images were analyzed. Lung injury, composed by hypo- and non-inflated areas, was significantly more represented in subpleural than in core lung regions. A secondary, centripetal spread of lung injury was associated with exposure to mechanical ventilation (p<0.04), longer spontaneous breathing (more than 14 days, p<0.05) and non-protective tidal volume (p<0.04). Positive fluid balance (p<0.01), high plasma D-dimers (p<0.01) and ferritin (p<0.04) were associated with increased lung injury.ConclusionsIn a cohort of COVID-19 patients with severe respiratory failure, a predominant subpleural distribution of lung injury is observed. Prolonged spontaneous breathing and high tidal volumes, both causes of patient self-induced lung injury, are associated to an extensive involvement of more central regions. Positive fluid balance, inflammation and thrombosis are associated with lung injury.Trial registration Study registered a priori the 20th of March, 2020. Clinical Trials ID NCT04316884.

Place, publisher, year, edition, pages
BioMed Central (BMC)Springer Nature, 2021
Keywords
COVID-19, SARS-CoV2, ARDS, Acute respiratory distress syndrome, Mechanical ventilation, Computed tomography
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-451716 (URN)10.1186/s13054-021-03685-4 (DOI)000684194900004 ()34348797 (PubMedID)
Funder
Knut and Alice Wallenberg Foundation, KAW 2020.0182Swedish Research Council, 2014-02569Swedish Research Council, 2014-07606Swedish Research Council, 201802438Swedish Heart Lung Foundation, 20170531
Available from: 2021-09-02 Created: 2021-09-02 Last updated: 2024-01-15Bibliographically approved
Simonson, O., Ståhle, E., Hansen, T., Wedin, J. O., Larsson, A., Mattsson, M., . . . Grinnemo, K.-H. (2020). 5-year Follow up After MSC-based Treatment of Severe Acute Respiratory Distress Syndrome [Letter to the editor]. American Journal of Respiratory and Critical Care Medicine, 202(7), 1051-1055
Open this publication in new window or tab >>5-year Follow up After MSC-based Treatment of Severe Acute Respiratory Distress Syndrome
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2020 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 202, no 7, p. 1051-1055Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
American Thoracic Society, 2020
Keywords
ARDS, Cell therapy, ECMO, MSC
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-416187 (URN)10.1164/rccm.202003-0544LE (DOI)000576807300027 ()32501728 (PubMedID)
Funder
Åke Wiberg FoundationErik, Karin och Gösta Selanders FoundationSwedish Heart Lung Foundation
Available from: 2020-07-13 Created: 2020-07-13 Last updated: 2020-11-19Bibliographically approved
Kuzniar, M., Tegler, G., Wanhainen, A., Ahlström, H., Mani, K. & Hansen, T. (2020). Feasibility of Assessing Inflammation in Asymptomatic Abdominal Aortic Aneurysms With Integrated 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging. European Journal of Vascular and Endovascular Surgery, 59(3), 464-471
Open this publication in new window or tab >>Feasibility of Assessing Inflammation in Asymptomatic Abdominal Aortic Aneurysms With Integrated 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging
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2020 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 59, no 3, p. 464-471Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study aimed to evaluate the feasibility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) combined with contrast enhanced magnetic resonance imaging (MRI) to identify inflammation in asymptomatic abdominal aortic aneurysms (AAA).

METHODS: FDG PET/MRI was performed on 15 patients with asymptomatic infrarenal AAAs >45 mm diameter. Prevalence of FDG uptake and MRI findings of inflammatory changes (oedema, wall thickening, and late gadolinium enhancement [LGE]) in the aortic wall were investigated at three levels: suprarenal aorta; non-aneurysmal aortic neck; and AAA.

RESULTS: The median diameter of the AAAs was 54 mm (range 47-65 mm) and the median expansion rate in the last 12 months was 3 mm (range 1-13 mm). The standard uptake value (SUV) of FDG in the aneurysmal wall (SUVmax 2.5) was higher than the blood pool (SUVmax 1.0; p < .001). The maximum target to background ratio was higher in the suprarenal aorta (mean ± SD; 3.1 ± 0.6) and aortic neck (2.7 ± 0.5) than in the aneurysmal aorta (2.5 ± 0.5; p < .001). Thirty-six FDG hotspots were observed in the aneurysmal wall of 13 patients. Wall thickening and LGE were identified in eight patients. The number of FDG hotspots correlated with recent AAA growth (r = 0.62, p = .01). The recent aneurysm expansion rate was higher in aneurysms with LGE than in those without (7 mm vs. 2 mm; p = .03). MRI inflammatory changes were observed in nine of 36 hot spots (25%) and in three of 13 patients with focal FDG uptake.

CONCLUSION: Fully integrated FDG PET/MRI can be used to study inflammation in asymptomatic AAAs. Heterogenous uptake of FDG in the aneurysmal wall indicates increased glucose metabolism, suggesting an ongoing inflammation. However, these FDG hotspots rarely correspond to MRI findings of inflammation, raising the question of which type of cellular activity is present in these areas. The presence of LGE and FDG hotspots both correlated to recent aneurysm growth, and their usefulness as clinical markers of aneurysm growth warrant additional investigation.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Abdominal aortic aneurysm, Inflammation, Magnetic resonance, Molecular imaging, Positron emission tomography
National Category
Cardiac and Cardiovascular Systems Radiology, Nuclear Medicine and Medical Imaging Surgery
Identifiers
urn:nbn:se:uu:diva-397555 (URN)10.1016/j.ejvs.2019.04.004 (DOI)000518375700020 ()31708339 (PubMedID)
Funder
Swedish Heart Lung Foundation, 20170647
Note

K. Mani and T. Hansen contributed equally to this publication.

Available from: 2019-11-21 Created: 2019-11-21 Last updated: 2022-08-17Bibliographically approved
Hansen, T., Nilsson, M., Lindholm, D. P., Sundström, J. & Hedberg, J. (2019). Normal radiological lymph node appearance in the thorax. Diseases of the esophagus, 32(10), 1-6
Open this publication in new window or tab >>Normal radiological lymph node appearance in the thorax
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2019 (English)In: Diseases of the esophagus, ISSN 1120-8694, E-ISSN 1442-2050, Vol. 32, no 10, p. 1-6Article in journal (Refereed) Published
Abstract [en]

Modern treatment of esophageal cancer is multimodal and highly dependent on a detailed diagnostic assessment of clinical stage, which includes nodal stage. Clinical appraisal of nodal stage is highly dependent on knowledge of normal radiological appearance, information of which is scarce. We aimed to describe lymph node appearance on computed tomography (CT) investigations in a randomly selected cohort of healthy subjects. In a sample of the Swedish Cardiopulmonary bioimage study, which investigates a sample of the Swedish population aged 50-64 years, the CT scans of 426 subjects were studied in detail concerning intrathoracic node stations relevant in clinical staging of esophageal cancer. With stratification for sex, the short axis of visible lymph nodes was measured and the distribution of lymph node sizes was calculated as well as proportion of patients with visible nodes above 5 and 10 millimeters for each station. Probability of having any lymph node station above 5 and 10 millimeters was calculated with a logistic regression model adjusted for age and sex. In the 214 men (aged: 57.3 +/- 4.1 years) and 212 women (aged: 57.8 +/- 4.4 years) included in this study, a total of 309 (72.5%) had a lymph node with a short axis of 5 mm or above was seen in at least one of the node stations investigated. When using 10 mm as a cutoff, nodes were visible in 29 (6.81%) of the subjects. Men had higher odds of having any lymph node with short axis 5 mm or above (OR 3.03 95% CI 1.89-4.85, P < 0.001) as well as 10 mm or above (OR 2.31 95% CI 1.02-5.23, P = 0.044) compared to women. Higher age was not associated with propensity for lymph nodes above 5 or 10 millimeters in this sample. We conclude that, in a randomly selected cohort of patients between 50 and 64 years, almost 10% of the men and 4% of the women had lymph nodes above 10 millimeters, most frequently in the subcarinal station (station 107). More than half of the patients had nodes above 5 millimeters on CT and men were much more prone to have this finding. The probability of finding lymph nodes in specific stations relevant of esophageal cancer is now described.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC, 2019
Keywords
cancer staging, computed tomography (CT), esophageal and gastric cancer
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-404699 (URN)10.1093/dote/doy120 (DOI)000506801600001 ()30561570 (PubMedID)
Funder
Swedish Heart Lung FoundationSwedish Cancer Society
Available from: 2020-02-27 Created: 2020-02-27 Last updated: 2020-02-27Bibliographically approved
Ekström, M. P., Blomberg, A., Bergstrom, G., Brandberg, J., Caidahl, K., Engstrom, G., . . . Lindberg, E. (2019). The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study. Thorax, 74(10), 958-964
Open this publication in new window or tab >>The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study
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2019 (English)In: Thorax, ISSN 0040-6376, E-ISSN 1468-3296, Vol. 74, no 10, p. 958-964Article in journal (Refereed) Published
Abstract [en]

Introduction Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.

Methods This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.

Results We included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.

Conclusion Breathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP, 2019
Keywords
dyspnoea, sex, weight, lung function, lung volume
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:uu:diva-395787 (URN)10.1136/thoraxjnl-2019-213349 (DOI)000487508000008 ()31434752 (PubMedID)
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaSwedish Heart Lung FoundationSwedish Society of Medicine
Available from: 2019-10-28 Created: 2019-10-28 Last updated: 2019-12-19Bibliographically approved
Hansen, T., Kilander, L., Ahlström, H. & Lind, L. (2018). Total atherosclerotic burden measured by magnetic resonance imaging is related to five-year decline in cognitive function. Clinical Physiology and Functional Imaging, 38(3), 373-377
Open this publication in new window or tab >>Total atherosclerotic burden measured by magnetic resonance imaging is related to five-year decline in cognitive function
2018 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 38, no 3, p. 373-377Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this study was to explore whether total atherosclerotic burden is related to future decline in performance on cognitive tests.

Methods: The total atherosclerotic burden (TAS) was assessed by whole‐body magnetic resonance angiography (WBMRA) in 305 subjects at age 70 in the study Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS). The mini‐mental state examination (MMSE) and trail making tests (TMT) A and B were evaluated at ages 75 and 80 in 190 of those subjects. No subject with a diagnosis of dementia was included in the sample.

Results: MMSE did not change during the 5 years of follow‐up, while TMT A and B increased by 4 and 7 s, respectively. TAS at age 70 was significantly related to the individual change in TMT B (P<0·0001) between age 75 and 80, when adjusted for sex, education level, TMT B at age 75 and Framingham score at age 70. No such relationship was seen for the change in TMT A (P = 0·10). The relationship between TAS and the change in MMSE was of borderline significance (P = 0·025).

Conclusion: A relationship was found between the total atherosclerotic burden and future decline in performance on TMT B, highlighting a role of global atherosclerosis in the cognitive decline seen during ageing.

Keywords
Atherosclerosis, dementia, magnetic resonance angiography, mild cognitive impairment, mini-mental state examination, trail making tests
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-322144 (URN)10.1111/cpf.12423 (DOI)000430103100005 ()28402078 (PubMedID)
Funder
Swedish Research CouncilAstraZeneca
Available from: 2017-05-16 Created: 2017-05-16 Last updated: 2018-06-19Bibliographically approved
Batista Borges, J., Hansen, T., Larsson, A. & Hedenstierna, G. (2017). The "normal" ventilated airspaces suffer the most damaging effects of mechanical ventilation. Intensive Care Medicine, 43(7), 1057-1058
Open this publication in new window or tab >>The "normal" ventilated airspaces suffer the most damaging effects of mechanical ventilation
2017 (English)In: Intensive Care Medicine, ISSN 0342-4642, E-ISSN 1432-1238, Vol. 43, no 7, p. 1057-1058Article in journal, Editorial material (Other academic) Published
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-333825 (URN)10.1007/s00134-017-4708-1 (DOI)000404020100016 ()28204859 (PubMedID)
Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2020-02-07Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-3481-979X

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