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Wikström, Johan, ProfessorORCID iD iconorcid.org/0000-0002-9481-6857
Alternative names
Biography [swe]

Min forskning rör hjärnans struktur och funktion, hos friska och vid olika typer av sjukliga processer. Flör detta använder jag framför allt magnetresonanstomografi, med fokus på olika fysiologiska och metabola MR-tekniker, t.ex. MR-perfusion, flödesmätningar med faskontrastteknik, funktionell MR (f-MRI), diffusion tensor imaging (DTI) och MR-spektroskopi (MRS). Positronemissionstomografi (PET) med olika spårsubstanser används också i flera projekt.

Bland olika forskningsområden kan nämnas diagnostik och behandlingsmonitorering av hjärntumörer, patofysiologiska studier av hjärnpåverkan vid preeklampsi samt makro- och mikrostrukturella och funktionella förändringar i hjärnan hos prematurfödda barn. Jag har också studerat radiologiska förändringar i hjärnan hos spädbarn som utretts under misstanke om skakvåld.

Publications (10 of 120) Show all publications
Kundu, S., Banerjee, S., Breznik, E., Toumpanakis, D., Wikström, J., Strand, R. & Kumar Dhara, A. (2024). ASE-Net for Segmentation of Post-operative Glioblastoma and Patient-specific Fine-tuning for Segmentation Refinement of Follow-up MRI Scans. SN computer science, 5(106)
Open this publication in new window or tab >>ASE-Net for Segmentation of Post-operative Glioblastoma and Patient-specific Fine-tuning for Segmentation Refinement of Follow-up MRI Scans
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2024 (English)In: SN computer science, E-ISSN 2661-8907, Vol. 5, no 106Article in journal (Refereed) Published
Abstract [en]

Volumetric quantification of tumors is usually done manually by radiologists requiring precious medical time and suffering from inter-observer variability. An automatic tool for accurate volume quantification of post-operative glioblastoma would reduce the workload of radiologists and improve the quality of follow-up monitoring and patient care. This paper deals with the 3-D segmentation of post-operative glioblastoma using channel squeeze and excitation based attention gated network (ASE-Net). The proposed deep neural network has a 3-D encoder and decoder based architecture with channel squeeze and excitation (CSE) blocks and attention blocks. The CSE block reduces the dependency on space information and put more emphasize on the channel information. The attention block suppresses the feature maps of irrelevant background and helps highlighting the relevant feature maps. The Uppsala university data set used has post-operative follow-up MRI scans for fifteen patients. A patient specific fine-tuning approach is used to improve the segmentation results for each patient. ASE-Net is also cross-validated with BraTS-2021 data set. The mean dice score of five-fold cross validation results with BraTS-2021 data set for enhanced tumor is 0.8244. The proposed network outperforms the competing networks like U-Net, Attention U-Net and Res U-Net. On the Uppsala University glioblastoma data set, the mean Dice score obtained with the proposed network is 0.7084, Hausdorff Distance-95 is 7.14 and the mean volumetric similarity achieved is 0.8579. With fine-tuning the pre-trained network, the mean dice score improved to 0.7368, Hausdorff Distance-95 decreased to 6.10 and volumetric similarity improved to 0.8736. ASE-Net outperforms the competing networks and can be used for volumetric quantification of post-operative glioblastoma from follow-up MRI scans. The network significantly reduces the probability of over segmentation.

Place, publisher, year, edition, pages
Springer, 2024
National Category
Medical Image Processing
Research subject
Computerized Image Processing
Identifiers
urn:nbn:se:uu:diva-498177 (URN)10.1007/s42979-023-02425-5 (DOI)
Available from: 2023-03-10 Created: 2023-03-10 Last updated: 2024-03-07Bibliographically approved
Karimi, A., Setänen, S., Larsson, E., Holmström, G., Fredriksson Kaul, Y., Kochukhova, O., . . . Wikström, J. (2024). Brain MRI findings and their association with visual impairment in young adolescents born very preterm. Neuroradiology, 66(1), 145-154
Open this publication in new window or tab >>Brain MRI findings and their association with visual impairment in young adolescents born very preterm
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2024 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 66, no 1, p. 145-154Article in journal (Refereed) Published
Abstract [en]

Purpose

Very preterm birth increases risk for neonatal white matter injury, but there is limited data on to what extent this persists into adolescence and how this relates to ophthalmological outcomes. The aim of this study was to assess brain MRI findings in 12-year-old children born very preterm compared to controls and their association with concurrent ophthalmological outcomes.

Methods

We included 47 children born very preterm and 22 full-term controls (gestational age <32 and >37 weeks, respectively). Brain MRI findings were studied in association with concurrent ophthalmological outcomes at 12-year follow-up.

Results

Evans index (0.27 vs 0.25, p<0.001) and a proposed “posterior ventricle index” (0.47 vs 0.45, p=0.018) were increased in children born very preterm. Higher gestational age associated with larger corpus callosum area (β=10.7, 95%CI 0.59–20.8). Focal white matter lesions were observed in 15 (32%) of very preterm children and in 1 (5%) of full-term controls. Increased posterior ventricle index increased risk for visual acuity ≤1.0 (OR=1.07×1011, 95%CI=7.78–1.48×1021) and contrast sensitivity <0.5 (OR=2.6×1027, 95%CI=1.9×108–3.5×1046). Decreased peritrigonal white matter thickness associated with impaired visual acuity (β=0.04, 95%CI 0.002–0.07).

Conclusion

More white matter lesions and evidence of lower white matter volume were found in children born very preterm compared with full-term controls at 12-year follow-up. The association between larger posterior ventricle index and reduced visual acuity and contrast sensitivity suggests disturbances of the posterior visual pathway due to diffuse white matter lesions.

Place, publisher, year, edition, pages
Springer, 2024
Keywords
Long-term follow-up, Visual impairment, White matter injury, Gestational age, Preterm birth
National Category
Radiology, Nuclear Medicine and Medical Imaging Pediatrics Ophthalmology
Identifiers
urn:nbn:se:uu:diva-515632 (URN)10.1007/s00234-023-03235-5 (DOI)001089850100002 ()37870588 (PubMedID)
Funder
Swedish Research Council, 2016/03109Uppsala University
Available from: 2023-11-08 Created: 2023-11-08 Last updated: 2024-02-21Bibliographically approved
Pal, S. C., Toumpanakis, D., Wikström, J., Ahuja, C. K., Strand, R. & Dhara, A. K. (2024). Multi-level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA towards Diagnosis of Cerebrovascular Disorders. IEEE Transactions on Nanobioscience, 23(1), 167-175
Open this publication in new window or tab >>Multi-level Residual Dual Attention Network for Major Cerebral Arteries Segmentation in MRA towards Diagnosis of Cerebrovascular Disorders
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2024 (English)In: IEEE Transactions on Nanobioscience, ISSN 1536-1241, E-ISSN 1558-2639, Vol. 23, no 1, p. 167-175Article in journal (Refereed) Published
Abstract [en]

Segmentation of major brain vessels is very important for the diagnosis of cerebrovascular disorders and subsequent surgical planning. Vessel segmentation is an important pre-processing step for a wide range of algorithms for the automatic diagnosis or treatment of several vascular pathologies and as such, it is valuable to have a well-performing vascular segmentation pipeline. In this article, we propose an end-to-end multiscale residual dual attention deep neural network for resilient major brain vessel segmentation. In the proposed network, the encoder and decoder blocks of the U-Net are replaced with the multi-level atrous residual blocks to enhance the learning capability by increasing the receptive field to extract the various semantic coarse- and fine- grained features. Dual attention block is incorporated in the bottleneck to perform effective multiscale information fusion to obtain detailed structure of blood vessels. The methods were evaluated on the publicly available TubeTK data set. The proposed method outperforms the state-of-the-art techniques with dice of 0.79 on the whole-brain prediction. The statistical and visual assessments indicate that proposed network is robust to outliers and maintains higher consistency in vessel continuity than the traditional U-Net and its variations.

Place, publisher, year, edition, pages
IEEE, 2024
National Category
Medical Image Processing
Research subject
Computerized Image Processing
Identifiers
urn:nbn:se:uu:diva-509426 (URN)10.1109/tnb.2023.3298444 (DOI)001136804800012 ()
Funder
Vinnova, 2020-03616
Available from: 2023-08-18 Created: 2023-08-18 Last updated: 2024-02-19Bibliographically approved
Katsarogiannis, E., Landtblom, A.-M., Kristoffersson, A., Wikström, J., Semnic, R. & Berntsson, S. G. (2023). Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis. Journal of Clinical Medicine, 12(14), Article ID 4656.
Open this publication in new window or tab >>Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis
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2023 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, no 14, article id 4656Article in journal (Refereed) Published
Abstract [en]

Background: Immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) are absent in a small group of multiple sclerosis (MS) patients. According to previous research, OCB-negative MS patients differ genetically but not clinically from OCB-positive MS patients. However, whether OCB-negative MS is a unique immunological and clinical entity remains unclear. The absence of OCB poses a significant challenge in diagnosing MS. (1)

Objective: The objective of this study was twofold: (1) to determine the prevalence of OCB-negative MS patients in the Uppsala region, and (2) to assess the frequency of misdiagnosis in this patient group. (2)

Methods: We conducted a retrospective study using data from the Swedish MS registry (SMSreg) covering 83% of prevalent MS cases up to 20 June 2020 to identify all MS patients in the Uppsala region. Subsequently, we collected relevant information from the medical records of all OCB-negative MS cases, including age of onset, gender, presenting symptoms, MRI features, phenotype, Expanded Disability Status Scale (EDSS) scores, and disease-modifying therapies (DMTs). (3) Results: Out of 759 MS patients identified, 69 had an OCB-negative MS diagnosis. Upon re-evaluation, 46 patients had a typical history and MRI findings of MS, while 23 had unusual clinical and/or radiologic features. An alternative diagnosis was established for the latter group, confirming the incorrectness of the initial MS diagnosis. The average EDSS score was 2.0 points higher in the MS group than in the non-MS group (p = 0.001). The overall misdiagnosis rate in the cohort was 33%, with 22% of misdiagnosed patients having received DMTs. (4)

Conclusions: Our results confirm that the absence of OCB in the CSF should raise suspicion of possible misdiagnosis in MS patients and prompt a diagnostic reassessment.

Place, publisher, year, edition, pages
MDPI AG, 2023
Keywords
multiple sclerosis, oligoclonal bands, differential diagnosis
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-508868 (URN)10.3390/jcm12144656 (DOI)001035332700001 ()37510771 (PubMedID)
Funder
Region Uppsala
Available from: 2023-08-11 Created: 2023-08-11 Last updated: 2023-08-11Bibliographically approved
Dubol, M., Immenschuh, J., Jonasson, M., Takahashi, K., Niwa, T., Hosoya, T., . . . Comasco, E. (2023). Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study. Comprehensive Psychiatry, 123, Article ID 152381.
Open this publication in new window or tab >>Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study
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2023 (English)In: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 123, article id 152381Article in journal (Refereed) Published
Abstract [en]

Background: Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving sex steroids could indeed be involved in the behavioural effects of nicotine, as it was found to inhibit aromatase in vitro and in vivo in rodents and non-human primates, respectively. Aromatase regulates the synthesis of oestrogens and, of relevance to addiction, is highly expressed in the limbic brain.

Methods: The present study sought to investigate in vivo aromatase availability in relation to exposure to nicotine in healthy women. Structural magnetic resonance imaging and two [11C]cetrozole positron emission tomography (PET) scans were performed to assess the availability of aromatase before and after administration of nicotine. Gonadal hormones and cotinine levels were measured. Given the region-specific expression of aromatase, a ROI -based approach was employed to assess changes in [11C]cetrozole non-displaceable binding potential.

Results: The highest availability of aromatase was found in the right and left thalamus. Upon nicotine exposure, [11C]cetrozole binding in the thalamus was acutely decreased bilaterally (Cohen's d =-0.99). In line, cotinine levels were negatively associated with aromatase availability in the thalamus, although as non-significant trend.

Conclusions: These findings indicate acute blocking of aromatase availability by nicotine in the thalamic area. This suggests a new putative mechanism mediating the effects of nicotine on human behaviour, particularly relevant to sex differences in nicotine addiction.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Addiction, Aromatase, Brain, Nicotine, PET, Women
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-501091 (URN)10.1016/j.comppsych.2023.152381 (DOI)000962543000001 ()36905856 (PubMedID)
Funder
Science for Life Laboratory, SciLifeLab
Available from: 2023-05-04 Created: 2023-05-04 Last updated: 2023-05-04Bibliographically approved
Lewén, A., Fahlström, M., Borota, L., Larsson, E.-M., Wikström, J. & Enblad, P. (2023). ASL-MRI-guided evaluation of multiple burr hole revascularization surgery in Moyamoya disease. Acta Neurochirurgica, 165(8), 2057-2069
Open this publication in new window or tab >>ASL-MRI-guided evaluation of multiple burr hole revascularization surgery in Moyamoya disease
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2023 (English)In: Acta Neurochirurgica, ISSN 0001-6268, E-ISSN 0942-0940, Vol. 165, no 8, p. 2057-2069Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Moyamoya (MM) disease is characterized by progressive intracranial arterial stenosis. Patients commonly need revascularization surgery to optimize cerebral blood flow (CBF). Estimation of CBF and cerebrovascular reserve (CVR) is therefore necessary before and after surgery. However, assessment of CBF before and after indirect revascularization surgery with the multiple burr hole (MBH) technique in MM has not been studied extensively. In this study, we describe our initial experience using arterial spin labeling magnetic resonance perfusion imaging (ASL-MRI) for CBF and CVR assessment before and after indirect MBH revascularization surgery in MM patients.

METHODS: Eleven MM patients (initial age 6-50 years, 1 male/10 female) with 19 affected hemispheres were included. A total of 35 ASL-MRI examinations were performed using a 3D-pCASL acquisition before and after i.v. acetazolamide challenge (1000 mg in adults and 10 mg/kg in children). Twelve MBH procedures were performed in seven patients. The first follow-up ASL-MRI was performed 7-21 (mean 12) months after surgery.

RESULTS: Before surgery, CBF was 46 ± 16 (mean ± SD) ml/100 g/min and CVR after acetazolamide challenge was 38.5 ± 9.9 (mean ± SD)% in the most affected territory (middle cerebral artery). In cases in which surgery was not performed, CVR was 56 ± 12 (mean ± SD)% in affected hemispheres. After MBH surgery, there was a relative change in CVR compared to baseline (preop) of + 23.5 ± 23.3% (mean ± SD). There were no new ischemic events.

CONCLUSION: Using ASL-MRI we followed changes in CBF and CVR in patients with MM. The technique was encouraging for assessments before and after revascularization surgery.

Place, publisher, year, edition, pages
Springer Nature, 2023
Keywords
Cerebrovascular reserve, Indirect revascularization, Moyamoya disease, Moyamoya syndrome, Multiple burr hole technique, Outcome
National Category
Radiology, Nuclear Medicine and Medical Imaging Surgery
Identifiers
urn:nbn:se:uu:diva-505308 (URN)10.1007/s00701-023-05641-3 (DOI)001009178600001 ()37326844 (PubMedID)
Funder
Uppsala UniversityThe Swedish Stroke Association
Available from: 2023-06-19 Created: 2023-06-19 Last updated: 2024-01-08Bibliographically approved
Banerjee, S., Toumpanakis, D., Dhara, A., Wikström, J. & Strand, R. (2023). Deep Curriculum Learning for Follow-up MRI Registration in Glioblastoma. In: Medical Imaging 2023: Image Processing. Paper presented at SPIE Conference on Medical Imaging - Image Processing, San Diego, CA, USA, February 19-24, 2023. SPIE -Society of Photo-Optical Instrumentation Engineers, 12464, Article ID 124643I.
Open this publication in new window or tab >>Deep Curriculum Learning for Follow-up MRI Registration in Glioblastoma
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2023 (English)In: Medical Imaging 2023: Image Processing, SPIE -Society of Photo-Optical Instrumentation Engineers , 2023, Vol. 12464, article id 124643IConference paper, Published paper (Refereed)
Abstract [en]

This paper presents a weakly supervised deep convolutional neural network-based approach to perform voxel-level3D registration between subsequent follow-up MRI scans of the same patient. To handle the large deformation inthe surrounding brain tissues due to the tumor’s mass effect we proposed curriculum learning-based training forthe network. Weak supervision helps the network to concentrate more focus on the tumor region and resectioncavity through a saliency detection network. Qualitative and quantitative experimental results show the proposedregistration network outperformed two popular state-of-the-art methods.

Place, publisher, year, edition, pages
SPIE -Society of Photo-Optical Instrumentation Engineers, 2023
Series
Progress in Biomedical Optics and Imaging, ISSN 1605-7422, E-ISSN 2410-904
National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Research subject
Computerized Image Processing
Identifiers
urn:nbn:se:uu:diva-490229 (URN)10.1117/12.2654143 (DOI)001011420500113 ()9781510660335 (ISBN)9781510660342 (ISBN)
Conference
SPIE Conference on Medical Imaging - Image Processing, San Diego, CA, USA, February 19-24, 2023
Funder
Vinnova, 2020-03616
Available from: 2022-12-08 Created: 2022-12-08 Last updated: 2023-08-16Bibliographically approved
Svedung-Wettervik, T., Fahlström, M., Wikström, J., Enblad, P. & Lewén, A. (2023). Editorial: Moyamoya disease - natural history and therapeutic challenges. Frontiers in Neurology, 14, Article ID 1270197.
Open this publication in new window or tab >>Editorial: Moyamoya disease - natural history and therapeutic challenges
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2023 (English)In: Frontiers in Neurology, E-ISSN 1664-2295, Vol. 14, article id 1270197Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
cerebral blood flow, imaging, moyamoya disease, revascularization, stroke
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-513325 (URN)10.3389/fneur.2023.1270197 (DOI)001069566100001 ()37731851 (PubMedID)
Available from: 2023-10-05 Created: 2023-10-05 Last updated: 2023-10-06Bibliographically approved
Fanni, G., Kagios, C., Roman, E., Sundbom, M., Wikström, J., Haller, S. & Eriksson, J. (2023). Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia. Endocrine, 79(2), 304-312
Open this publication in new window or tab >>Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia
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2023 (English)In: Endocrine, ISSN 1355-008X, E-ISSN 1559-0100, Vol. 79, no 2, p. 304-312Article in journal (Refereed) Published
Abstract [en]

Introduction

Roux-en-Y gastric bypass (RYGB) leads to beneficial effects on glucose homeostasis, and attenuated hormonal counterregulatory responses to hypoglycemia are likely to contribute. RYGB also induces alterations in neural activity of cortical and subcortical brain regions. We aimed to characterize RYGB-induced changes in resting-state connectivity of specific brain regions of interest for energy homeostasis and behavioral control during hypoglycemia.

Method

Ten patients with BMI > 35 kg/m2 were investigated with brain PET/MR imaging during a hyperinsulinemic normo- and hypoglycemic clamp, before and 4 months after RYGB. Hormonal levels were assessed throughout the clamp. Resting-state (RS) fMRI scans were acquired in the glucose-lowering phase of the clamp, and they were analyzed with a seed-to-voxel approach.

Results

RS connectivity during initiation of hypoglycemia was significantly altered after RYGB between nucleus accumbens, thalamus, caudate, hypothalamus and their crosstalk with cortical and subcortical regions. Connectivity between the nucleus accumbens and the frontal pole was increased after RYGB, and this was associated with a reduction of ACTH (r = −0.639, p = 0.047) and cortisol (r = −0.635, p = 0.048) responses. Instead, connectivity between the caudate and the frontal pole after RYGB was reduced and this was associated with less attenuation of glucagon response during the hypoglycemic clamp (r = −0.728, p = 0.017), smaller reduction in fasting glucose (r = −0.798, p = 0.007) and less excess weight loss (r = 0.753, p = 0.012). No other significant associations were found between post-RYGB changes in ROI-to-voxel regional connectivity hormonal responses and metabolic or anthropometric outcomes.

Conclusion

RYGB alters brain connectivity during hypoglycemia of several neural pathways involved in reward, inhibitory control, and energy homeostasis. These changes are associated with altered hormonal responses to hypoglycemia and may be involved in the glucometabolic outcome of RYGB.

Place, publisher, year, edition, pages
Springer Nature, 2023
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Radiology
Identifiers
urn:nbn:se:uu:diva-489736 (URN)10.1007/s12020-022-03253-y (DOI)000914873500001 ()36459336 (PubMedID)
Funder
Diabetesfonden, 2019-490EXODIAB - Excellence of Diabetes Research in SwedenErnfors FoundationSwedish Society for Medical Research (SSMF)P.O. Zetterling FoundationNovo Nordisk Foundation, NNF20OC0063864EU, Horizon 2020, MSCA-ITN-721236Uppsala University
Available from: 2022-12-03 Created: 2022-12-03 Last updated: 2023-08-28Bibliographically approved
Fahlström, M., Svedung-Wettervik, T., Enblad, P., Lewén, A. & Wikström, J. (2023). Evaluation of single-delay arterial spin labeling-based spatial coefficient of variation and histogram-based parameters in relation to cerebrovascular reserve in patients with Moyamoya disease.. Frontiers in Neurology, 14, Article ID 1137046.
Open this publication in new window or tab >>Evaluation of single-delay arterial spin labeling-based spatial coefficient of variation and histogram-based parameters in relation to cerebrovascular reserve in patients with Moyamoya disease.
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2023 (English)In: Frontiers in Neurology, E-ISSN 1664-2295, Vol. 14, article id 1137046Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Single-delay Arterial Spin Labeling (ASL)-based spatial coefficient of variation (CoVCBF) has been suggested as a measure of hemodynamic disturbance in patients with cerebrovascular diseases. However, spatial CoVCBF and other histogram-based parameters such as skewness and kurtosis and the volume of the arterial transit time artefact (ATAvol), has not been evaluated in patients with MMD nor against cerebrovascular reserve (CVR). The aim of this study was to assess whether any associations between spatial CoVCBF, skewness, kurtosis, and ATAvol are present and to analyze any potential associations with CVR, derived from single-delay ASL in patients with MMD.

METHODS: Fifteen MMD patients were included before or after revascularization surgery. Cerebral blood flow (CBF) maps were acquired using pseudo-continuous ASL before, and 5, 15, and 25 min after an intravenous acetazolamide injection. CVRmax was defined as the highest percentual increase in CBF at any of the three post-injection time points. A vascular territory template was spatially normalized to each patient, including the bilateral anterior, middle, and posterior cerebral arteries. All affected anterior and middle cerebral artery regions and all unaffected posterior cerebral artery regions were included, based on Suzuki grading by digital subtraction angiography.

RESULTS: Significant differences between affected and unaffected regions were found for CBF, CVRmax, and ATAvol. No association was found between CVRmax and any other parameter. High correlations were found between spatial CoVCBF, skewness and ATAvol.

CONCLUSION: Spatial CoVCBF derived from single-delay ASL does not correlate with CVR in patients with MMD. Moreover, skewness and kurtosis did not provide additional information of clinical value.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
Moyamoya, arterial spin label (ASL) MRI, arterial transit time artefact (ATA), cerebrovascular reserve, spatial coefficient of variation
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-505307 (URN)10.3389/fneur.2023.1137046 (DOI)001008700800001 ()37325230 (PubMedID)
Available from: 2023-06-19 Created: 2023-06-19 Last updated: 2023-08-28Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9481-6857

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