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Dahlbom, I
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Publications (10 of 20) Show all publications
Paulmichl, K., Ahlström, H., Bergsten, P., Brunner, S., Cadamuro, J., Dahlbom, I., . . . Weghuber, D. (2017). Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents: Results of the Beta-JUDO Study. Acta Paediatrica, 106(S470), 13-13
Open this publication in new window or tab >>Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents: Results of the Beta-JUDO Study
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no S470, p. 13-13Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
Childhood, Hyperferritinemia, NAFLD, Obesity, Steatosis
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-366465 (URN)10.1111/apa.14093 (DOI)000440296300021 ()
Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2018-11-22Bibliographically approved
Dahlbom, I., Lidström, M., Vilen, H., Andersson, K., Ciba, I., Kritikos, D. & Forslund, A. (2017). Daily Assessments of Perceived Sensations in Obese and Non-Obese Children/Adolescents Using a New Mobile Application. Acta Paediatrica, 106, 14-14
Open this publication in new window or tab >>Daily Assessments of Perceived Sensations in Obese and Non-Obese Children/Adolescents Using a New Mobile Application
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, p. 14-14Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
adolescents, hunger, obesity, mobile application, stress
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-366466 (URN)10.1111/apa.14093 (DOI)000440296300024 ()
Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-11-21Bibliographically approved
Forslund, A., Weghuber, D., Paulmichl, K., Zsoldos, F., Widhalm, K., Vheu, M. D., . . . Bergsten, P. (2017). Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents. Acta Paediatrica, 106(470), 14-15
Open this publication in new window or tab >>Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 470, p. 14-15Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
Pediatric obesity, reduced glucose tolerance, NAFLD, GLP-1 analog, Exenatide
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-366467 (URN)10.1111/apa.14093 (DOI)000440296300025 ()
Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-11-21Bibliographically approved
Dahlbom, I., Nyberg, B.-I., Berntson, L. & Hansson, T. (2016). Simultaneous detection of IgA and IgG antibodies against tissue transglutaminase: The preferred pre-biopsy test in childhood celiac disease. Scandinavian Journal of Clinical and Laboratory Investigation, 76(3), 208-216
Open this publication in new window or tab >>Simultaneous detection of IgA and IgG antibodies against tissue transglutaminase: The preferred pre-biopsy test in childhood celiac disease
2016 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 76, no 3, p. 208-216Article in journal (Refereed) Published
Abstract [en]

Objectives: IgA antibodies against tissue transglutaminase (anti-TG2) is a reliable marker of celiac disease (CD). However, IgA-deficient patients are not identified and young children may lack IgA anti-TG2. Combined detection of IgA and IgG (IgA/IgG) against deamidated gliadin peptides (DGP) has shown a high diagnostic performance for untreated CD. Here we examined the utility of IgA/IgG anti-TG2, IgA/IgG anti-DGP and IgA/IgG against a mix of TG2 and DGP (anti-TG2/DGP) in finding CD among children.

Methods: Serum antibodies against TG2, DGP, and TG2/DGP were determined with ELISA in 242 children referred to a paediatric gastroenterologist. Fifty had untreated CD verified by an intestinal biopsy and 192/242 children had other diseases than CD.

Results: Forty-eight untreated CD children had increased IgA/IgG anti-TG2, 47/50 had increased IgA/IgG anti-DGP and 46/50 had increased IgA/IgG anti-TG2/DGP. One control subject had increased IgA/IgG anti-TG2 and IgA/IgG anti-TG2/DGP, whereas 7/192 control subjects had increased IgA/IgG anti-DGP. The IgA/IgG anti-TG2 assay had the best performance with a sensitivity of 96%, a specificity of 99.5% and the area under the ROC-curve was 0.996 (95% CI 0.992-1, p < 0.0001).

Conclusions: Detection of one antibody is not sufficient when screening for untreated CD among children due to cases of IgA deficiency. The inclusion of DGP antigens in the IgA/IgG combination assays seems to affect the sensitivity and specificity negatively, whereas detection of IgA/IgG anti-TG2 has the potential of finding most untreated CD patients, including those with IgA deficiency.

Keywords
tissue transglutaminase, gliadin, children, autoantibodies, Celiac disease
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-294678 (URN)10.3109/00365513.2015.1137348 (DOI)000372195200005 ()26924622 (PubMedID)
Funder
VINNOVA, 2007-00084
Available from: 2016-06-01 Created: 2016-05-26 Last updated: 2017-11-30Bibliographically approved
Hansson, T., Dahlbom, I., Tuvemo, T. & Frisk, G. (2015). Silent coeliac disease is over-represented in children with type 1 diabetes and their siblings. Acta Paediatrica, 104(2), 185-191
Open this publication in new window or tab >>Silent coeliac disease is over-represented in children with type 1 diabetes and their siblings
2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 2, p. 185-191Article in journal (Refereed) Published
Abstract [en]

AimThis study measured autoantibodies against tissue transglutaminase (anti-tTG) to detect untreated coeliac disease in children with type 1 diabetes and their siblings. MethodsAnti-tTG was measured in prospectively collected sera from 169 children at the onset of diabetes, 88 of their siblings and 96 matched control children. Coeliac disease was confirmed with a small intestinal biopsy. ResultsCoeliac disease was diagnosed in five children before diabetes onset. A further 12 children were diagnosed after diabetes onset, without any gastrointestinal symptoms, and 11 of these had anti-tTG at the onset of diabetes, with the remaining child showing seroconversion within 6months. Hence, all the children with both diseases had anti-tTG at or before diabetes diagnosis, and the prevalence of coeliac disease was 10.1%. Moreover, 6.8% of the siblings and 3.1% of the control children had elevated levels of anti-tTG. None of the siblings reported any coeliac-related symptoms, despite being positive for anti-tTG, and coeliac disease has so far been biopsy confirmed in 4.5%. ConclusionSilent coeliac disease is over-represented in children with type 1 diabetes and their siblings. All diabetes children and their siblings should be tested and followed for the presence of anti-tTG and coeliac disease.

Keywords
Autoantibodies, Coeliac disease, tissue transglutaminase, Type 1 diabetes
National Category
Pediatrics Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-246809 (URN)10.1111/apa.12823 (DOI)000348731000024 ()25283799 (PubMedID)
Available from: 2015-03-16 Created: 2015-03-10 Last updated: 2017-12-04Bibliographically approved
Enroth, S., Dahlbom, I., Hansson, T., Johansson, Å. & Gyllensten, U. (2013). Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study. International Journal of Circumpolar Health, 72, 21403
Open this publication in new window or tab >>Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study
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2013 (English)In: International Journal of Circumpolar Health, ISSN 2242-3982, E-ISSN 2242-3982, Vol. 72, p. 21403-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Atopic allergy is effected by a number of environmental exposures, such as dry air and time spent outdoors, but there are few estimates of the prevalence in populations from sub-arctic areas.

OBJECTIVE:

To determine the prevalence and severity of symptoms of food, inhalation and skin-related allergens and coeliac disease (CD) in the sub-arctic region of Sweden. To study the correlation between self-reported allergy and allergy test results. To estimate the heritability of these estimates.

STUDY DESIGN:

The study was conducted in Karesuando and Soppero in Northern Sweden as part of the Northern Sweden Population Health Study (n=1,068). We used a questionnaire for self-reported allergy and CD status and measured inhalation-related allergens using Phadiatop, food-related allergens using the F×5 assay and IgA and IgG antibodies against tissue transglutaminase (anti-tTG) to indicate prevalence of CD.

RESULTS:

The prevalence of self-reported allergy was very high, with 42.3% reporting mild to severe allergy. Inhalation-related allergy was reported in 26.7%, food-related allergy in 24.9% and skin-related allergy in 2.4% of the participants. Of inhalation-related allergy, 11.0% reported reactions against fur and 14.6% against pollen/grass. Among food-related reactions, 14.9% reported milk (protein and lactose) as the cause. The IgE measurements showed that 18.4% had elevated values for inhalation allergens and 11.7% for food allergens. Self-reported allergies and symptoms were positively correlated (p<0.01) with age- and sex-corrected inhalation allergens. Allergy prevalence was inversely correlated with age and number of hours spent outdoors. High levels of IgA and IgG anti-tTG antibodies, CD-related allergens, were found in 1.4 and 0.6% of participants, respectively. All allergens were found to be significantly (p<3 e-10) heritable, with estimated heritabilities ranging from 0.34 (F×5) to 0.65 (IgA).

CONCLUSIONS:

Self-reported allergy correlated well with the antibody measurements. The prevalence of allergy was highest in the young and those working inside. Heritability of atopy and sensitization was high. The prevalence of CD-related autoantibodies was high and did not coincide with the self-reported allergy.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-206290 (URN)10.3402/ijch.v72i0.21403 (DOI)000325721900153 ()23986895 (PubMedID)
Available from: 2013-08-30 Created: 2013-08-30 Last updated: 2018-07-06Bibliographically approved
Simon-Vecsei, Z., Kiraly, R., Bagossi, P., Toth, B., Dahlbom, I., Caja, S., . . . Korponay-Szabo, I. R. (2012). A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 431-436
Open this publication in new window or tab >>A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects
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2012 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 109, no 2, p. 431-436Article in journal (Refereed) Published
Abstract [en]

The multifunctional, protein cross-linking transglutaminase 2 (TG2) is the main autoantigen in celiac disease, an autoimmune disorder with defined etiology. Glutamine-rich gliadin peptides from ingested cereals, after their deamidation by TG2, induce T-lymphocyte activation accompanied by autoantibody production against TG2 in 1-2% of the population. The pathogenic role and exact binding properties of these antibodies to TG2 are still unclear. Here we show that antibodies from different celiac patients target the same conformational TG2 epitope formed by spatially close amino acids of adjacent domains. Glu153 and 154 on the first alpha-helix of the core domain and Arg19 on first alpha-helix of the N-terminal domain determine the celiac epitope that is accessible both in the closed and open conformation of TG2 and dependent on the relative position of these helices. Met659 on the C-terminal domain also can cooperate in antibody binding. This composite epitope is disease-specific, recognized by antibodies derived from celiac tissues and associated with biological effects when passively transferred from celiac mothers into their newborns. These findings suggest that celiac antibodies are produced in a surface-specific way for which certain homology of the central glutamic acid residues of the TG2 epitope with deamidated gliadin peptides could be a structural basis. Monoclonal mouse antibodies with partially overlapping epitope specificity released celiac antibodies from patient tissues and antagonized their harmful effects in cell culture experiments. Such antibodies or similar specific competitors will be useful in further functional studies and in exploring whether interference with celiac antibody actions leads to therapeutic benefits.

Keywords
conformational epitope, endomysial antibodies, immunotherapy
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-168091 (URN)10.1073/pnas.1107811108 (DOI)000298950200024 ()
Available from: 2012-02-08 Created: 2012-02-06 Last updated: 2017-12-08Bibliographically approved
Lindholm, Å., Blomquist, C., Bixo, M., Dahlbom, I., Hansson, T., Sundström-Poromaa, I. & Burén, J. (2011). No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls. Human Reproduction, 26(6), 1478-1485
Open this publication in new window or tab >>No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls
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2011 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 26, no 6, p. 1478-1485Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies have indicated that peripheral circulating markers of inflammation are elevated in women with polycystic ovary syndrome (PCOS), but thus far no studies concerning markers of inflammation in adipose tissue have been published. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue.

Methods: Twenty overweight patients with PCOS, 10 lean patients with PCOS and 20 overweight controls had subcutaneous fat biopsies and blood samples taken. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR.

Results: Overweight patients with PCOS had higher relative adipose tissue chemokine ligand 2 (P < 0.01), and its cognate receptor (P < 0.05), tumour necrosis factor-alpha (P < 0.001), interleukin (IL)-10 (P < 0.001) and IL-18 (P < 0.001) and the monocyte/ macrophage markers CD14 (P < 0.01) and CD163 (P < 0.01) mRNA levels compared with lean women with PCOS. There were no differences between overweight patients with PCOS and overweight control subjects in this respect. Within the PCOS group, markers of adipose tissue inflammation correlated significantly with obesity-related metabolic disturbances, but when data were adjusted for age and BMI, most correlations were lost.

Conclusions: Overweight, rather than the PCOS diagnosis per se, appears to be the main explanatory variable for elevated adipose tissue inflammation in patients with PCOS.

Keywords
polycystic ovary syndrome, adipose tissue, inflammatory markers, metabolic syndrome, overweight
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-152021 (URN)10.1093/humrep/der096 (DOI)000290818400024 ()21478181 (PubMedID)
Available from: 2011-04-20 Created: 2011-04-20 Last updated: 2017-12-11Bibliographically approved
Gingnell, M., Dahlbom, I., Lindholm, Å., Hudecova, M., Arnadottir, R., Hansson, T. & Sundström-Poromaa, I. (2011). Patients with polycystic ovary syndrome have lower levels of IgM anti-phosphorylcholine antibodies than healthy women. Gynecological Endocrinology, 27(7), 486-490
Open this publication in new window or tab >>Patients with polycystic ovary syndrome have lower levels of IgM anti-phosphorylcholine antibodies than healthy women
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2011 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 27, no 7, p. 486-490Article in journal (Refereed) Published
Abstract [en]

Introduction. IgM antibodies against phosphorylcholine (IgM anti-PC) are natural autoantibodies, possibly exerting one of the atheroprotective functions of the immune system. Increased levels of these antibodies reduce the development of atherosclerosis in mice, and low levels of IgM anti-PC have been associated with increased risk for cardiovascular disease (CVD). This study compared levels of IgM anti-PC in women with polycystic ovary syndrome (PCOS, n = 111) and healthy controls (n = 79). Method. Levels of IgM anti-PC were measured with ELISA. Results. The median level of IgM anti-PC in patients with PCOS was not significantly different compared to control subjects. However, the proportion of patients with PCOS with low levels of IgM anti-PC, defined as number of individuals below the median level, was significantly higher than among healthy controls, p < 0.05. Patients with PCOS in the oldest age quintile had significantly lower level of IgM anti-PC than control subjects of similar age (p < 0.05) and younger women with PCOS (p < 0.01). Conclusion. Our results indicate that women with PCOS more frequently display below-median levels of IgM anti-PC than controls and older women with PCOS have lower median anti-PC levels. Further studies of how this finding translates into actual CVD risk in women with PCOS are needed.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-140555 (URN)10.3109/09513590.2010.501880 (DOI)000291221600007 ()20645890 (PubMedID)
Available from: 2011-01-05 Created: 2011-01-05 Last updated: 2017-12-11Bibliographically approved
de Faire, U., Su, J., Hua, X., Frostegård, A., Halldin, M., Hellenius, M.-L., . . . Frostegård, J. (2010). Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: Effects on uptake of oxidized LDL in macrophages as a potential mechanism. Journal of Autoimmunity, 34(2), 73-79
Open this publication in new window or tab >>Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: Effects on uptake of oxidized LDL in macrophages as a potential mechanism
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2010 (English)In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 34, no 2, p. 73-79Article in journal (Refereed) Published
Abstract [en]

Objective: We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). Methods: From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ischemic stroke, or hospitalized angina pectoris) and 633 age- and sex-matched controls were identified through a 5-7 year follow-up. Serum levels of IgM anti-PC was determined by ELISA. Anti-PC was extracted from pooled human IgM and the effect of anti-PC on the uptake of OxLDL was studied by FACScan. Results: Relative risks (RR) with 95% confidence intervals (Cl) by quartiles of anti-PC levels with quartile 4 set as the reference value (RR = 1.0) and adjusted for smoking, BMI, type 11 diabetes, hypercholesterolaemia, and high blood pressure yielded an excess risk for CVD only for those within the lowest quartile of anti-PC values with an RR of 1.37 (CI 0.87-2.16). However, for men stronger associations were noted with increasing multivariately adjusted RRs from quartile 4 to quartile 1. Subjects within quartile I (values below 29.7 U/ml) had a significantly increased RR of 1.96 (Cl 1.09-3.55). Further adjustments for hsCRP gave essentially the same results. No excess risk was noted for women. Specific anti-PC could be extracted from IgM and these antibodies inhibited macrophage uptake of OxLDL Conclusions: Low IgM anti-PC could be a novel risk marker for CVD among men. One possible mechanism could be inhibition of uptake of oxLDL in macrophages.

Keywords
Atherosclerosis, Innate immunity, Natural antibodies, Phosphorylcholine, Cardiovascular disease
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-137139 (URN)10.1016/j.jaut.2009.05.003 (DOI)000275216100001 ()19726160 (PubMedID)
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2017-12-11Bibliographically approved
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