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Wright, Dominic
Publications (3 of 3) Show all publications
Wright, D., Kerje, S., Brändström, H., Schütz, K., Kindmark, A., Andersson, L., . . . Pizzari, T. (2008). The genetic architecture of a female sexual ornament. Evolution, 62(1), 86-98
Open this publication in new window or tab >>The genetic architecture of a female sexual ornament
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2008 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 62, no 1, p. 86-98Article in journal (Refereed) Published
Abstract [en]

Understanding the evolution of sexual ornaments, and particularly that of female sexual ornaments, is an enduring challenge in evolutionary biology. Key to this challenge are establishing the relationship between ornament expression and female reproductive investment, and determining the genetic basis underpinning such relationship. Advances in genomics provide unprecedented opportunities to study the genetic architecture of sexual ornaments in model species. Here, we present a quantitative trait locus (QTL) analysis of a female sexual ornament, the comb of the fowl, Gallus gallus, using a large-scale intercross between red junglefowl and a domestic line, selected for egg production. First, we demonstrate that female somatic investment in comb reflects female reproductive investment. Despite a trade-off between reproductive and skeletal investment mediated by the mobilization of skeletal minerals for egg production, females with proportionally large combs also had relatively high skeletal investment. Second, we identify a major QTL for bisexual expression of comb mass and several QTL specific to female comb mass. Importantly, QTL for comb mass were nonrandomly clustered with QTL for female reproductive and skeletal investment on chromosomes one and three. Together, these results shed light onto the physiological and genetic architecture of a female ornament.

Keywords
Female ornaments, genetic quality, male mate choice, QTL, sexual selection
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-14716 (URN)10.1111/j.1558-5646.2007.00281.x (DOI)000252108700008 ()18053076 (PubMedID)
Available from: 2008-01-31 Created: 2008-01-31 Last updated: 2017-12-11Bibliographically approved
Rubin, C.-J., Brändström, H., Wright, D., Kerje, S., Gunnarsson, U., Schütz, K., . . . Kindmark, A. (2007). Quantitative Trait Loci for BMD and Bone Strength in an Intercross Between Domestic and Wildtype Chickens. Journal of Bone and Mineral Research, 22(3), 375-384
Open this publication in new window or tab >>Quantitative Trait Loci for BMD and Bone Strength in an Intercross Between Domestic and Wildtype Chickens
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2007 (English)In: Journal of Bone and Mineral Research, ISSN 0884-0431, E-ISSN 1523-4681, Vol. 22, no 3, p. 375-384Article in journal (Refereed) Published
Abstract [en]

With chicken used as a model species, we used QTL analysis to examine the genetic contribution to bone traits. We report the identification of four QTLs for femoral traits: one for bone strength, one for endosteal circumference, and two affecting mineral density of noncortical bone. Introduction: BMD is a highly heritable phenotype, governed by elements at numerous loci. In studies examining the genetic contribution to bone traits, many loci have been identified in humans and in other species. The goal of this study was to identify quantitative trait loci (QTLs) controlling BMD and bone strength in an intercross between wildtype and domestic chickens. Materials and Methods: A set of 164 markers, covering 30 chromosomes (chr.), were used to genotype 337 F 2-individuals from an intercross of domesticated white Leghorn and wildtype red junglefowl chicken. DXA and pQCT were used to measure BMD and bone structure. Three-point bending tests and torsional strength tests were performed to determine the biomechanical strength of the bone. QTLs were mapped using forward selection for loci with significant marginal effects. Results: Four QTLs for femoral bone traits were identified in QTL analysis with body weight included as a covariate. A QTL on chr. 1 affected female noncortical BMD (LOD 4.6) and is syntenic to human 12q21-12q23. Also located on chr. 1, a locus with synteny to human 12q 13-1.4 affected endosteal circumference (LOD 4.6). On chr. 2, a QTL corresponding to human 5p13-p15, 7p12, 18q12, 18q21, and 9q22-9q31 affected BMD in females; noncortical (LOD 4.0) and metaphyseal (LOD 7.0) BMD by pQCT and BMD by DXA (LOD 5.9). A QTL located on chr. 20 (LOD 5.2) affected bone biomechanical strength and had sex-dependent effects. In addition to the significant QTLs, 10 further loci with suggestive linkage to bone traits were identified. Conclusions: Four QTLs were identified: two for noncortical BMD, one for endosteal circumference, and one affecting bone biomechanical strength. The future identification of genes responsible for these QTLs will increase the understanding of vertebrate skeletal biology.

Keywords
chicken, quantitative trait loci, BMD, biomechanics
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-96811 (URN)10.1359/jbmr.061203 (DOI)000244619400005 ()17181401 (PubMedID)
Available from: 2008-03-06 Created: 2008-03-06 Last updated: 2017-12-14Bibliographically approved
Wright, D., Kerje, S., Lundström, K., Babol, J., Schütz, K., Jensen, P. & Andersson, L. (2006). Quantitative trait loci analysis of egg and meat production traits in a red junglefowl x White Leghorn cross. Animal Genetics, 37(6), 529-534
Open this publication in new window or tab >>Quantitative trait loci analysis of egg and meat production traits in a red junglefowl x White Leghorn cross
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2006 (English)In: Animal Genetics, ISSN 0268-9146, E-ISSN 1365-2052, Vol. 37, no 6, p. 529-534Article in journal (Refereed) Published
Abstract [en]

Egg and production traits are of considerable economic importance in chickens. Using a White Leghorn x red junglefowl F-2 intercross, standard production measures of liver weight and colour, egg size, eggshell thickness, egg taste and meat quality were taken. A total of 160 markers covering 29 autosomes and the Z chromosome were genotyped on 175-243 individuals, depending on the trait under consideration. A total of nine significant quantitative trait loci (QTL) and three suggestive QTL were found on chicken chromosomes 1, 2, 4, 5, 7, 8, 10, 12, E47W24 and E22C19W28.

Keywords
egg characteristics, production traits, quantitative trait locus, red junglefowl, White Leghorn
National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-22647 (URN)10.1111/j.1365-2052.2006.01515.x (DOI)000242198300001 ()17121597 (PubMedID)
Available from: 2007-01-23 Created: 2007-01-23 Last updated: 2017-12-07Bibliographically approved
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