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Sundström Poromaa, IngerORCID iD iconorcid.org/0000-0002-2491-2042
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Publications (10 of 283) Show all publications
Holstad, Y., Johansson, B., Lindqvist, M., Westergren, A., Sundström Poromaa, I., Christersson, C., . . . Bay, A. (2024). Breastfeeding in primiparous women with congenital heart disease: a register study. International Breastfeeding Journal, 19(1), Article ID 19.
Open this publication in new window or tab >>Breastfeeding in primiparous women with congenital heart disease: a register study
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2024 (English)In: International Breastfeeding Journal, E-ISSN 1746-4358, Vol. 19, no 1, article id 19Article in journal (Refereed) Published
Abstract [en]

Background

The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for breastfeeding in women with CHD.

Methods

The data were gathered between 2014 and 2019 and obtained by merging the Swedish Congenital Heart Disease Register (SWEDCON) with the Swedish Pregnancy Register. Primiparous women ≥ 18 years of age with CHD (n = 578) were matched by age and municipality to 3049 women without CHD, giving birth after 22 gestational weeks. Multivariable logistic regression analysis was used to identify factors associated with non-breastfeeding in women with CHD.

Results

Fewer women with CHD breastfed than women without CHD two days (94% vs. 97%, p = 0.001) and four weeks after birth (84% vs. 89%, p = 0.006). When all women were analysed, having CHD was associated with non-breastfeeding at both two days and four weeks after birth. For women with CHD, body mass index (BMI) ≥ 30 (OR 3.1; 95% CI 1.4, 7.3), preterm birth (OR 6.4; 95% CI 2.1, 19.0), self-reported history of psychiatric illness (OR 2.4; 95% CI 1.2, 5.1), small for gestational age (OR 4.2; 95% CI 1.4, 12.2), and New York Heart Association Stages of Heart Failure class II − III (OR 6.0; 95% CI 1.4, 26.7) were associated with non-breastfeeding two days after birth. Four weeks after birth, factors associated with non-breastfeeding were BMI ≥ 30 (OR 4.3; 95% CI 2.1, 9.0), self-reported history of psychiatric illness (OR 2.2; 95% CI 1.2, 4.2), and preterm birth (OR 8.9; 95% CI 2.8, 27.9).

Conclusions

The study shows that most women with CHD breastfeed, however, at a slightly lower proportion compared to women without CHD. In addition, factors related to the heart disease were not associated with non-breastfeeding four weeks after birth. Since preterm birth, BMI ≥ 30, and psychiatric illness are associated with non-breastfeeding, healthcare professionals should provide greater support to women with CHD having these conditions.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2024
Keywords
Heart defects congenital, Breastfeeding, Maternal health, Postpartum period, adult congenital heart disease (ACHD)
National Category
Nursing Cardiac and Cardiovascular Systems Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-526215 (URN)10.1186/s13006-024-00627-y (DOI)001190554400002 ()38509505 (PubMedID)
Funder
Umeå UniversityNorrländska HjärtfondenSwedish Heart Lung FoundationThe Swedish Heart and Lung Association
Available from: 2024-04-10 Created: 2024-04-10 Last updated: 2024-04-10Bibliographically approved
Lindberger, E., Ahlsson, F., Junus, K., Wikström, A.-K. & Sundström Poromaa, I. (2024). Combined maternal central adiposity measures in relation to infant birth size. Scientific Reports, 14, Article ID 725.
Open this publication in new window or tab >>Combined maternal central adiposity measures in relation to infant birth size
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2024 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, article id 725Article in journal (Refereed) Published
Abstract [en]

Improvement of prenatal identification of large-for-gestational-age (LGA) infants could lower the risk for adverse outcomes. Therefore, we sought to evaluate the association of a combination of maternal waist circumference (WC) and abdominal fat depths with infant birth size. A cohort study including 1240 women was performed between 2015 and 2018 at Uppsala University Hospital, Sweden. Maternal WC was measured at the first antenatal visit, and visceral (VF) and subcutaneous (SCF) fat depths by ultrasound at the second-trimester anomaly scan. Waist circumference, VF, and SCF were categorized as low or high (cut-offs WC ≥ 88 cm, VF ≥ 54 mm, SCF ≥ 21 mm). Outcomes were birth weight standard deviation score (BWSDS) and LGA (BWSDS > 90th and > 97th percentile). Secondary outcome was small-for-gestational-age (SGA, BWSDS < 10th and < 3rd percentile). Univariate analysis of variance and logistic regression analyses were performed adjusted for maternal weight, height, parity, smoking, country of birth, pregestational diabetes, and chronic hypertension. For both high and low WC, high VF was positively associated with BWSDS and LGA. There was no association with SGA. The results did not demonstrate any value of the combination of WC and fat depth measures in predicting infant birth size but suggested VF as a marker for large infants.

Place, publisher, year, edition, pages
Springer Nature, 2024
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-525406 (URN)10.1038/s41598-024-51274-6 (DOI)001137232700037 ()38184682 (PubMedID)
Funder
Uppsala University
Available from: 2024-03-22 Created: 2024-03-22 Last updated: 2024-03-22Bibliographically approved
Dubol, M., Stiernman, L., Sundström Poromaa, I., Bixo, M. & Comasco, E. (2024). Cortical morphology variations during the menstrual cycle in individuals with and without premenstrual dysphoric disorder. Journal of Affective Disorders, 355, 470-477
Open this publication in new window or tab >>Cortical morphology variations during the menstrual cycle in individuals with and without premenstrual dysphoric disorder
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2024 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 355, p. 470-477Article in journal (Refereed) Published
Abstract [en]

Background

Premenstrual dysphoric disorder (PMDD) is hypothesized to stem from maladaptive neural sensitivity to ovarian steroid hormone fluctuations. Recently, we found thinner cortices in individuals with PMDD, compared to healthy controls, during the symptomatic phase. Here, we aimed at investigating whether such differences illustrate state-like characteristics specific to the symptomatic phase, or trait-like features defining PMDD.

Methods

Patients and controls were scanned using structural magnetic resonance imaging during the mid-follicular and late-luteal phase of the menstrual cycle. Group-by-phase interaction effects on cortical architecture metrics (cortical thickness, gyrification index, cortical complexity, and sulcal depth) were assessed using surface-based morphometry.

Results

Independently of menstrual cycle phase, a main effect of diagnostic group on surface metrics was found, primarily illustrating thinner cortices (0.3 < Cohen's d > 1.1) and lower gyrification indices (0.4 < Cohen's d > 1.0) in patients compared to controls. Furthermore, menstrual cycle-specific effects were detected across all participants, depicting a decrease in cortical thickness (0.4 < Cohen's d > 1.7) and region-dependent changes in cortical folding metrics (0.4 < Cohen's d > 2.2) from the mid-follicular to the late luteal phase.

Limitations

Small effects (d = 0.3) require a larger sample size to be accurately characterized.

Conclusions

These findings provide initial evidence of trait-like cortical characteristics of the brain of individuals with premenstrual dysphoric disorder, together with indications of menstrual cycle-related variations in cortical architecture in patients and controls. Further investigations exploring whether these differences constitute stable vulnerability markers or develop over the years may help understand PMDD etiology.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Premenstrual dysphoric disorder, Grey matter, Magnetic resonance imaging, Surface-based morphometry, Menstrual cycle, Mental health
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-526352 (URN)10.1016/j.jad.2024.03.130 (DOI)38552916 (PubMedID)
Funder
Umeå UniversitySwedish Society of Medicine, SLS-573171Swedish Society of Medicine, SLS-597211Swedish Society of Medicine, SLS-789101EU, FP7, Seventh Framework Programme, INCA 600398Swedish Research Council, 2015-00495Swedish Research Council, 2016-01439Swedish Research Council, 2020-01801Swedish Research Council, 2021-03089The Swedish Brain Foundation, 2020-0255Science for Life Laboratory, SciLifeLab
Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2024-04-11Bibliographically approved
Kaltsouni, E., Schmidt, F., Zsido, R. G., Eriksson, A., Sacher, J., Sundström Poromaa, I., . . . Comasco, E. (2024). Electroencephalography findings in menstrually-related mood disorders: A critical review. Frontiers in Neuroendocrinology, 72, Article ID 101120.
Open this publication in new window or tab >>Electroencephalography findings in menstrually-related mood disorders: A critical review
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2024 (English)In: Frontiers in Neuroendocrinology, ISSN 0091-3022, E-ISSN 1095-6808, Vol. 72, article id 101120Article, review/survey (Refereed) Published
Abstract [en]

The female reproductive years are characterized by fluctuations in ovarian hormones across the menstrual cycle, which have the potential to modulate neurophysiological and behavioral dynamics. Menstrually-related mood disorders (MRMDs) comprise cognitive-affective or somatic symptoms that are thought to be triggered by the rapid fluctuations in ovarian hormones in the luteal phase of the menstrual cycle. MRMDs include premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and premenstrual exacerbation (PME) of other psychiatric disorders. Electroencephalography (EEG) non-invasively records in vivo synchronous activity from populations of neurons with high temporal resolution. The present overview sought to systematically review the current state of task-related and resting-state EEG investigations on MRMDs. Preliminary evidence indicates lower alpha asymmetry at rest being associated with MRMDs, while one study points to the effect being lutealphase specific. Moreover, higher luteal spontaneous frontal brain activity (slow/fast wave ratio as measured by the delta/beta power ratio) has been observed in persons with MRMDs, while sleep architecture results point to potential circadian rhythm disturbances. In this review, we discuss the quality of study designs as well as future perspectives and challenges of supplementing the diagnostic and scientific toolbox for MRMDs with EEG.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Brain, EEG, Females, Menstrual cycle, Premenstrual dysphoric disorder, Premenstrual exacerbation, Premenstrual syndrome
National Category
Physiology Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-526118 (URN)10.1016/j.yfrne.2023.101120 (DOI)001173958700001 ()38176542 (PubMedID)
Available from: 2024-04-05 Created: 2024-04-05 Last updated: 2024-04-05Bibliographically approved
Björvang, R. D., Walldén, Y., Fransson, E., Comasco, E., Sundström Poromaa, I. & Skalkidou, A. (2024). Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms. Psychoneuroendocrinology, 164, Article ID 107009.
Open this publication in new window or tab >>Mid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms
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2024 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 164, article id 107009Article in journal (Refereed) Published
Abstract [en]

Perinatal depression is a major cause of disability for individuals giving birth worldwide, with detrimental effects on short- and long-term parental and child outcomes. There is emerging evidence that the neuroactive steroid hormone allopregnanolone is implicated in the pathophysiology and course of perinatal mood symptoms. However, no study thus far has examined allopregnanolone levels whilst making use of longitudinal data on depressive symptom trajectories throughout the perinatal period. The present study investigated levels of allopregnanolone at gestational week 17 of 252 participants in relation to perinatal depressive symptom trajectories, with a secondary aim of exploring the role of history of depression as an effect modifier. Four perinatal depressive symptom trajectories were investigated: controls (no depressive symptoms throughout perinatal period) (N=161), antepartum (depressive symptoms prenatally with postpartum remission) (N=31), postpartumonset (no depressive symptoms during pregnancy, development of depressive symptoms postpartum) (N=23), and persistent (depressive symptoms throughout the perinatal period) (N=37). Results show that for every one nmol/l increase in allopregnanolone, there was 7% higher odds for persistent depressive symptoms (OR 1.07, 95% CI 1.01-1.14) compared to controls. No association was seen for antepartum and postpartum-onset depressive symptoms. History of depression did not modify the association between allopregnanolone and perinatal depressive symptom trajectories. These results show the role of allopregnanolone for persistent depressive symptoms and strengthen the hypothesis of differences in pathophysiology among the trajectories.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Allopregnanolone, Perinatal depression, Trajectories Antepartum, depressive symptoms, Postpartum-onset depressive symptoms, Persistent depressive symptoms
National Category
Obstetrics, Gynecology and Reproductive Medicine Public Health, Global Health, Social Medicine and Epidemiology Psychiatry
Identifiers
urn:nbn:se:uu:diva-528212 (URN)10.1016/j.psyneuen.2024.107009 (DOI)001210209900001 ()38442504 (PubMedID)
Available from: 2024-05-22 Created: 2024-05-22 Last updated: 2024-05-22Bibliographically approved
Holstad, Y., Johansson, B., Lindqvist, M., Westergren, A., Sundström Poromaa, I., Christersson, C., . . . Bay, A. (2024). Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study. Scandinavian Cardiovascular Journal, 58(1), Article ID 2295782.
Open this publication in new window or tab >>Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study
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2024 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 58, no 1, article id 2295782Article in journal (Refereed) Published
Abstract [en]

Background. Poor maternal self-rated health in healthy women is associated with adverse neonatal outcomes, but knowledge about self-rated health in pregnant women with congenital heart disease (CHD) is sparse. This study, therefore, investigated self-rated health before, during, and after pregnancy in women with CHD and factors associated with poor self-rated health.

Methods. The Swedish national registers for CHD and pregnancy were merged and searched for primiparous women with data on self-rated health; 600 primiparous women with CHD and 3062 women in matched controls. Analysis was performed using descriptive statistics, chi-square test and logistic regression.

Results. Women with CHD equally often rated their health as poor as the controls before (15.5% vs. 15.8%, p = .88), during (29.8% vs. 26.8% p = .13), and after pregnancy (18.8% vs. 17.6% p = .46). None of the factors related to heart disease were associated with poor self-rated health. Instead, factors associated with poor self-rated health during pregnancy in women with CHD were ≤12 years of education (OR 1.7, 95%CI 1.2–2.4) and self-reported history of psychiatric illness (OR 12.6, 95%CI 1.4–3.4). After pregnancy, solely self-reported history of psychiatric illness (OR 5.2, 95%CI 1.1–3.0) was associated with poor self-rated health.

Conclusion. Women with CHD reported poor self-rated health comparable to controls before, during, and after pregnancy, and factors related to heart disease were not associated with poor self-rated health. Knowledge about self-rated health may guide professionals in reproductive counselling for women with CHD. Further research is required on how pregnancy affects self-rated health for the group in a long-term perspective.

Place, publisher, year, edition, pages
Taylor & Francis, 2024
Keywords
Self-rated health, women, heart defects congenital, adult congenital heart disease (ACHD), pregnancy, reproductive health, chronic disease
National Category
Public Health, Global Health, Social Medicine and Epidemiology Nursing
Identifiers
urn:nbn:se:uu:diva-519506 (URN)10.1080/14017431.2023.2295782 (DOI)001129021600001 ()38130125 (PubMedID)
Funder
Swedish Heart Lung FoundationUmeå University
Available from: 2024-01-09 Created: 2024-01-09 Last updated: 2024-01-09Bibliographically approved
Jonsson, S., Sundström Poromaa, I., Johansson, B., Alenius Dahlqvist, J., Christersson, C., Dellborg, M., . . . Bay, A. (2024). Time to childbirth and assisted reproductive treatment in women with congenital heart disease. Open heart, 11(1), Article ID e002591.
Open this publication in new window or tab >>Time to childbirth and assisted reproductive treatment in women with congenital heart disease
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2024 (English)In: Open heart, E-ISSN 2053-3624, Vol. 11, no 1, article id e002591Article in journal (Refereed) Published
Abstract [en]

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls. Results 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first childbirth (28.9 vs 28.5 years, p=0.04) and ART was more common (6.1% vs 4.0%, p<0.01) compared with controls. There were no differences in ART when stratifying for the complexity of CHD. For all women, higher age was associated with ART treatment (OR 1.24, 95% CI 1.20 to 1.28). Conclusions Women with and without CHD who gave birth to a first child did so at similar ages. ART was more common in women with CHD, but disease severity did not influence the need for ART. Age was an important risk factor for ART also in women with CHD and should be considered in consultations with these patients.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2024
Keywords
heart defects, congenital, pregnancy, epidemiology
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-526217 (URN)10.1136/openhrt-2023-002591 (DOI)001186478600001 ()38485120 (PubMedID)
Funder
Swedish Heart Lung FoundationNorrländska Hjärtfonden
Available from: 2024-04-10 Created: 2024-04-10 Last updated: 2024-04-10Bibliographically approved
Kaltsouni, E., Wikström, J., Lanzenberger, R., Sundström Poromaa, I. & Comasco, E. (2024). White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder. Psychoneuroendocrinology, 163, Article ID 106977.
Open this publication in new window or tab >>White matter volume and treatment with selective progesterone receptor modulator in patients with premenstrual dysphoric disorder
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2024 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 163, article id 106977Article in journal (Refereed) Published
Abstract [en]

Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found to differ between patients with PMDD and healthy controls. The present study thus sought to investigate the relationship between white matter volume and SPRM treatment in patients with PMDD. A pharmaco-neuroimaging study was conducted on patients with PMDD participating in a randomized controlled trial. Participants underwent magnetic resonance imaging before and after treatment randomization to ulipristal acetate (an SPRM), or placebo, for three months. The interaction effect of treatment by time on white matter volume (WMV) was assessed. Voxel based morphometry analyses were performed on both a whole brain exploratory level and on regions of interest. No treatment effect was observed on WMV in any region, including the anterior thalamic radiations, cingulum, forceps minor, fornix, inferior fronto-occipital fasciculus, superior cerebellar peduncle, superior longitudinal fasciculus, and uncinate fasciculus. This is the first finding to indicate that no white matter volume alterations follow three-month progesterone antagonism, suggesting that white matter volume does not participate in symptom relief upon SPRM treatment for PMDD.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
PMDD, White matter volume, Progesterone antagonism, Ovarian hormones, VBM
National Category
Neurosciences Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-521592 (URN)10.1016/j.psyneuen.2024.106977 (DOI)001171599800001 ()38295626 (PubMedID)
Funder
Swedish Research Council, 2016-01439Swedish Research Council, 2020-01801Swedish Society of Medicine, SLS-573171Swedish Society of Medicine, SLS-597211Swedish Society of Medicine, SLS-789101The Swedish Brain Foundation, 2020-0255Science for Life Laboratory, SciLifeLab
Available from: 2024-01-25 Created: 2024-01-25 Last updated: 2024-03-21Bibliographically approved
Dubol, M., Immenschuh, J., Jonasson, M., Takahashi, K., Niwa, T., Hosoya, T., . . . Comasco, E. (2023). Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study. Comprehensive Psychiatry, 123, Article ID 152381.
Open this publication in new window or tab >>Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study
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2023 (English)In: Comprehensive Psychiatry, ISSN 0010-440X, E-ISSN 1532-8384, Vol. 123, article id 152381Article in journal (Refereed) Published
Abstract [en]

Background: Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving sex steroids could indeed be involved in the behavioural effects of nicotine, as it was found to inhibit aromatase in vitro and in vivo in rodents and non-human primates, respectively. Aromatase regulates the synthesis of oestrogens and, of relevance to addiction, is highly expressed in the limbic brain.

Methods: The present study sought to investigate in vivo aromatase availability in relation to exposure to nicotine in healthy women. Structural magnetic resonance imaging and two [11C]cetrozole positron emission tomography (PET) scans were performed to assess the availability of aromatase before and after administration of nicotine. Gonadal hormones and cotinine levels were measured. Given the region-specific expression of aromatase, a ROI -based approach was employed to assess changes in [11C]cetrozole non-displaceable binding potential.

Results: The highest availability of aromatase was found in the right and left thalamus. Upon nicotine exposure, [11C]cetrozole binding in the thalamus was acutely decreased bilaterally (Cohen's d =-0.99). In line, cotinine levels were negatively associated with aromatase availability in the thalamus, although as non-significant trend.

Conclusions: These findings indicate acute blocking of aromatase availability by nicotine in the thalamic area. This suggests a new putative mechanism mediating the effects of nicotine on human behaviour, particularly relevant to sex differences in nicotine addiction.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Addiction, Aromatase, Brain, Nicotine, PET, Women
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-501091 (URN)10.1016/j.comppsych.2023.152381 (DOI)000962543000001 ()36905856 (PubMedID)
Funder
Science for Life Laboratory, SciLifeLab
Available from: 2023-05-04 Created: 2023-05-04 Last updated: 2024-04-08Bibliographically approved
Jonsdottir, B., Wikman, A., Sundström Poromaa, I. & Stålberg, K. (2023). Advanced gynecological cancer: Quality of life one year after diagnosis. PLOS ONE, 18(6), Article ID e0287562.
Open this publication in new window or tab >>Advanced gynecological cancer: Quality of life one year after diagnosis
2023 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 18, no 6, article id e0287562Article in journal (Refereed) Published
Abstract [en]

Objective: Gynaecological cancer treatment impacts women's physical and psychological health. Our objective was to examine quality of life (QoL) in women with advanced gynaecological cancer at diagnosis and one year later, and to identify sociodemographic and clinical characteristics associated with QoL.

Methods: Women with endometrial, ovarian or cervical cancer treated in Uppsala, Sweden 2012-2019 were included. FIGO stage & GE;II was considered advanced gynaecological cancer, whereas women in FIGO stage I were used as a control group. QoL was assessed with SF-36. We obtained information on sociodemographic and clinical characteristics from medical records and health questionnaires. Differences in QoL domains were tested with t-tests, a mixed model ANOVA and multiple linear regression analyses.

Results: The study population (n = 372) included 150 (40.3%) women with advanced gynaecological cancer. At diagnosis, women with advanced cancer reported lower physical (71.6 vs 81.8 (mean) p<0.05) and role functioning/physical scores (62.6 vs 77.2 (mean) p<0.05) than women in FIGO stage I. One year later, women with advanced cancer reported higher scores in the mental health domain (78.3 vs 73.2 (mean) p<0.05) than women in FIGO stage I. However, no difference was found in the QoL scores of women with advanced disease one year after diagnoses when stratified by diagnosis. Women with a history of psychiatric illness and higher BMI reported poorer physical and mental QoL at follow-up, while advanced stage, level of education and smoking were not associated with QoL.

Conclusion: Women with advanced gynaecological cancer have equally good QoL one year after diagnosis as women with limited disease. Women with previous psychiatric illness and high BMI, are at risk of impaired physical and mental health.

Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2023
National Category
Obstetrics, Gynecology and Reproductive Medicine Cancer and Oncology Nursing
Identifiers
urn:nbn:se:uu:diva-509998 (URN)10.1371/journal.pone.0287562 (DOI)001023897900122 ()37352193 (PubMedID)
Available from: 2023-08-28 Created: 2023-08-28 Last updated: 2023-08-28Bibliographically approved
Projects
Reproduction and psyche [2010-03293_VR]; Uppsala UniversityHow common are mood and sexual side-effects from combined oral contraceptives? [2012-01889_VR]; Uppsala UniversityPsychoneuroendocrinology of antenatal depression [2013-02339_VR]; Uppsala UniversitySelective progesterone receptor modulators for treatment of premenstrual dysphoric disorder [2016-01439_VR]; Uppsala UniversityPremenstrual dysphoric syndrome - role of progesterone and serotonin [2020-01801_VR]; Uppsala University
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-2491-2042

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