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Sörelius, Karl
Publications (10 of 18) Show all publications
Sörelius, K., Wanhainen, A. & Mani, K. (2020). Infective Native Aortic Aneurysms: Call for Consensus on Definition, Terminology, Diagnostic Criteria, and Reporting Standards. European Journal of Vascular and Endovascular Surgery, 59(3), 333-334
Open this publication in new window or tab >>Infective Native Aortic Aneurysms: Call for Consensus on Definition, Terminology, Diagnostic Criteria, and Reporting Standards
2020 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 59, no 3, p. 333-334Article in journal, Editorial material (Other academic) Published
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-408066 (URN)10.1016/j.ejvs.2019.11.008 (DOI)000518375700001 ()32131984 (PubMedID)
Available from: 2020-04-03 Created: 2020-04-03 Last updated: 2020-04-03Bibliographically approved
Sörelius, K., Svensson, J., Matthiessen, P., Rutegard, J. & Rutegard, M. (2019). A nationwide study on the incidence of mesenteric ischaemia after surgery for rectal cancer demonstrates an association with high arterial ligation. Colorectal Disease, 21(8), 925-931
Open this publication in new window or tab >>A nationwide study on the incidence of mesenteric ischaemia after surgery for rectal cancer demonstrates an association with high arterial ligation
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2019 (English)In: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318, Vol. 21, no 8, p. 925-931Article in journal (Refereed) Published
Abstract [en]

Aim

The incidence of mesenteric ischaemia after resection for rectal cancer has not been investigated in a population‐based setting. The use of high ligation of the inferior mesenteric artery might cause such ischaemia, as the bowel left in situ depends on collateral blood supply after a high tie.

Method

The Swedish Colorectal Cancer Registry was used to identify all patients subjected to an abdominal resection for rectal cancer during the years 2007–2017 inclusive. Mesenteric ischaemia within the first 30 postoperative days was recorded, classified as either stoma necrosis or colonic necrosis. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for mesenteric ischaemia in relation to high tie, with adjustment for confounding.

Results

Some 14 657 patients were included, of whom 59 (0.40%) had a reoperation for any type of mesenteric ischaemia, divided into 34 and 25 cases of stoma necrosis and colonic necrosis, respectively. Compared with patients who did not require reoperation for mesenteric ischaemia following rectal cancer surgery, the proportion having high tie was greater (54.2% vs 38.5%; P = 0.032). The adjusted OR for reoperation due to any mesenteric ischaemia with high tie was 2.26 (95% CI 1.34–3.79), while the corresponding estimates for stoma and colonic necrosis, respectively, were 1.60 (95% CI 0.81–3.17) and 3.69 (95% CI 1.57–8.66).

Conclusion

The incidence of reoperation for mesenteric ischaemia after abdominal resection for rectal cancer is low, but the use of a high tie might increase the risk of colonic necrosis demanding surgery.

Keywords
Inferior mesenteric artery, high tie, low tie, stoma necrosis, bowel ischaemia, central ligation, proximal ligation
National Category
Gastroenterology and Hepatology
Identifiers
urn:nbn:se:uu:diva-393120 (URN)10.1111/codi.14674 (DOI)000478607100012 ()31062468 (PubMedID)
Funder
Swedish Society of Medicine
Available from: 2019-09-24 Created: 2019-09-24 Last updated: 2019-09-24Bibliographically approved
Brown, P., Sörelius, K. & Zhou, Y. (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database: The Journal of Biological Databases and Curation, Article ID baz085.
Open this publication in new window or tab >>Large expert-curated database for benchmarking document similarity detection in biomedical literature search
2019 (English)In: Database: The Journal of Biological Databases and Curation, ISSN 1758-0463, E-ISSN 1758-0463, article id baz085Article in journal (Refereed) Published
Abstract [en]

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.

National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-397629 (URN)10.1093/database/baz085 (DOI)000494411700001 ()
Note

For complete list of authors see http://dx.doi.org/10.1093/database/baz085

Available from: 2019-11-22 Created: 2019-11-22 Last updated: 2019-11-22Bibliographically approved
Sörelius, K., Wanhainen, A., Wahlgren, C.-M., Langenskiöld, M., Roos, H., Resch, T., . . . Mani, K. (2019). Nationwide Study on Treatment of Mycotic Thoracic Aortic Aneurysms. European Journal of Vascular and Endovascular Surgery, 57(2), 239-246
Open this publication in new window or tab >>Nationwide Study on Treatment of Mycotic Thoracic Aortic Aneurysms
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2019 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 57, no 2, p. 239-246Article in journal (Refereed) Published
Abstract [en]

Objective: Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic aortic aneurysms (MTAAs).

Methods: Patients treated in Sweden for MTAAs between 2000 and 2016 were identified in the Swedish vascular registry (2010-16) and local patient registries (2000-09). Primary outcome was survival, and secondary outcomes included surgical strategy, rate of infection related complications (IRC), and re-operations.

Results: Fifty-two patients (median age 71 +/- 8.1 years; 28 [54%] men, 13 [25%] ruptured) were identified (3.6% of all thoracic aortic aneurysm repairs in Sweden). Aneurysm location was aortic arch (n = 6; 11%), descending aorta (n = 42; 81%), and multiple locations (n = 4; 8%). Twenty-nine (56%) patients had positive cultures; the most prevalent agent was Staphylococcus aureus (n = 16; 31%). Operative techniques included thoracic endovascular aortic repair (TEVAR; n = 35 [67%]), fenestrated/branched TEVAR (n = 8; 15%), hybrid repair (n = 7; 14%), and open patch repair (n = 2; 4%). Survival was 92% (95% confidence interval [CI] 88-96) at 30 days, 88% (95% CI 84-93) at three months, 78% (73-84) at one year, and 71% (64-77) at five years. The mean follow up among survivors (> 90 days) was 45 months (range 4-216 months). Antibiotics were administered for a median of 15 weeks (range 0-220 weeks). IRCs occurred in nine patients (17%): sepsis (n = 3), graft infection (n = 3), recurrent mycotic aneurysm (n = 1), aorto-oesophageal/bronchial fistula (n = 2). Six (67%) IRCs were fatal; 80% occurred within the first year. Re-operations were performed in nine patients (17%).

Conclusions: TEVAR was often used as treatment for MTAAs, with acceptable short- and long-term survival when compared with open cohorts in the literature. IRCs are of concern and warrant follow up and long-term antibiotic treatment.

Place, publisher, year, edition, pages
W B SAUNDERS CO LTD, 2019
Keywords
Aneurysm, Aorta, Infected, Mycotic, Thoracic, Treatment
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-379269 (URN)10.1016/j.ejvs.2018.08.052 (DOI)000459894800012 ()30340857 (PubMedID)
Available from: 2019-03-18 Created: 2019-03-18 Last updated: 2019-03-18Bibliographically approved
Sörelius, K., Schiraldi, L., Giordano, S., Oranges, C. M., Raffoul, W. & Di Summa, P. G. (2019). Reconstructive Surgery of Inguinal Defects: A Systematic Literature Review of Surgical Etiology and Reconstructive Technique. In Vivo, 33(1), 1-9
Open this publication in new window or tab >>Reconstructive Surgery of Inguinal Defects: A Systematic Literature Review of Surgical Etiology and Reconstructive Technique
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2019 (English)In: In Vivo, ISSN 0258-851X, E-ISSN 1791-7549, Vol. 33, no 1, p. 1-9Article, review/survey (Refereed) Published
Abstract [en]

Background/Aim: This study aimed to evaluate the literature regarding surgical etiology demanding inguinal reconstructive surgery, associated reconstructive techniques and outcomes.

Materials and Methods: A systematic literature search was performed according to the PRISMA statement between 1996-2016.

Results: A total of 64 articles were included, comprising 816 patients. Two main subgroups of patients were identified: Oncological resections (n = 255, 31%), and vascular surgery (n = 538, 66%). Oncological resection inguinal defects were treated with pedicled myocutaneous flaps (n = 166, 65%), fasciocutaneous flaps (77, 31%), muscle flaps (7, 3%) and direct closure (3, 1%). Vascular surgery complications were treated with muscle flaps (n = 513, 95%). Complications for the respective subgroup (oncological resections, vascular surgery) were: infection (24%, 14%), seroma (34%, 7.5%), flap dehiscence/delayed healing (20.6%, 40.8%,). The total reintervention rate was 20%.

Conclusion: Reconstruction of inguinal defects should be addressed on a case-by-case basis. Myocutaneous flaps were favoured after oncological resections, while muscle flaps were preferred after vascular surgery.

Keywords
Oncological surgery, vascular surgery, inguinal defect, reconstructive surgery, complications, review
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-373910 (URN)10.21873/invivo.11431 (DOI)000454333900001 ()30587595 (PubMedID)
Note

Karl Sörelius and Luigi Schiraldi contributed equally to this study.

Available from: 2019-01-17 Created: 2019-01-17 Last updated: 2019-01-17Bibliographically approved
Sörelius, K., Budtz-Lilly, J., Mani, K. & Wanhainen, A. (2019). Systematic Review of the Management of Mycotic Aortic Aneurysms. European Journal of Vascular and Endovascular Surgery, 58(3), 426-435
Open this publication in new window or tab >>Systematic Review of the Management of Mycotic Aortic Aneurysms
2019 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 58, no 3, p. 426-435Article, review/survey (Refereed) Published
Abstract [en]

Objectives: The aim of this systematic literature review was to compile an updated overview of mycotic aortic aneurysm (MAA) treatment and outcomes.

Methods: A systematic literature review was performed using the search terms mycotic and infected aortic aneurysms in the MEDLINE and ScienceDirect databases, published between January 2000 and September 2018. Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, articles were scrutinised regarding surgical technique, aortic segment involved, pre- and post-operative antibiotic regimens, survival and infection related complications (IRCs), and factors associated with adverse or favourable outcomes.

Results: Twenty-eight studies, with a total of 963 patients, were included. All publications were observational, retrospective studies. Patient and study heterogeneity, along with missing data, precluded meta-analyses. Overall treatment consisted of open surgical repair (OSR; n = 556 [58%]), endovascular aortic repair (EVAR; n = 373 [39%]), and medical treatment alone (n = 34 [3%]). OSR was the dominant surgical technique prior to 2010, shifting to EVAR thereafter. For MAAs located in the abdominal aorta, EVAR was associated with better short term survival than OSR. Antibiotic treatment for more than six months post-operatively was associated with better survival, but there was no consensus on the length of treatment. MAAs were complicated by IRCs in 21%, irrespective of surgical technique, of which 46%-70% were fatal. The most consistently reported factors associated with adverse outcomes were increasing age, rupture, suprarenal abdominal aneurysm location, and non-Salmonella positive culture.

Conclusions: With few exceptions, the literature mainly consists of small, retrospective single centre studies. Standardised reporting is needed to increase comparability of studies. EVAR appears to be associated with superior short term survival without late disadvantages, compared with OSR. This suggests that EVAR can be an acceptable alternative to OSR. However, MAA treatment should always be tailor made and planned individually, and general recommendations are in vain. IRCs pose a significant threat to patients after MAA repair and require further investigation.

Place, publisher, year, edition, pages
W B SAUNDERS CO LTD, 2019
Keywords
Aneurysm, EVAR, Infected, Aorta, Mycotic, Review, Surgery, Treatment
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-394719 (URN)10.1016/j.ejvs.2019.05.004 (DOI)000484010400026 ()31320247 (PubMedID)
Available from: 2019-10-11 Created: 2019-10-11 Last updated: 2019-10-11Bibliographically approved
Sörelius, K. & di Summa, P. G. (2018). On the Diagnosis of Mycotic Aortic Aneurysms. Clinical Medicine Insights: Cardiology, 12
Open this publication in new window or tab >>On the Diagnosis of Mycotic Aortic Aneurysms
2018 (English)In: Clinical Medicine Insights: Cardiology, ISSN 1179-5468, E-ISSN 1179-5468, Vol. 12Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: There is striking paucity in consensus on the terminology, definition, and diagnostic criteria of mycotic aortic aneurysms. This literature study aims to elucidate this scientific omission, discuss its consequences, and present a proposition for reporting items on this disease.

METHODS: A systematic literature review on PubMed and Medline using mycotic and infected aortic aneurysms between 1850 and 2017 was performed. Articles were assessed according to a protocol regarding terminology, definition, and diagnostic criteria. Case series with less than 5 patients were excluded.

RESULTS: A total of 49 articles were included. The most prevalent term was mycotic aortic aneurysm but there was no widely accepted definition. Most modern publications used a diagnostic workup based on a combination on clinical presentation, laboratory results, imaging findings, and intraoperative findings. How these protean variables should be balanced was unclear. A proposition of reporting items was framed and consisted of definition of disease used, basis of diagnostic workup, exclusion criteria, patient characteristics, laboratory and imaging findings, aneurysm anatomy, details on treatment, pre/postoperative antibiotic treatment, and details on follow-up.

CONCLUSIONS: This article emphasizes the need to standardize definition, terminology, and diagnostic criteria for mycotic aortic aneurysms and proposes reporting items enhancing comparability between studies.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2018
Keywords
Mycotic, aneurysm, infected, aorta, diagnosis, revised, terminology, criteria, reporting standards
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-349351 (URN)10.1177/1179546818759678 (DOI)000425618500001 ()29497343 (PubMedID)
Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-04-27Bibliographically approved
Heinola, I., Sörelius, K., Wyss, T. R., Eldrup, N., Settembre, N., Setacci, C., . . . Venermo, M. (2018). Open Repair of Mycotic Abdominal Aortic Aneurysms With Biological Grafts: An International Multicenter Study. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 7(12), Article ID e008104.
Open this publication in new window or tab >>Open Repair of Mycotic Abdominal Aortic Aneurysms With Biological Grafts: An International Multicenter Study
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2018 (English)In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 7, no 12, article id e008104Article in journal (Refereed) Published
Abstract [en]

Background-The treatment of mycotic abdominal aortic aneurysm requires surgery and antimicrobial therapy. Since prosthetic reconstructions carry a considerable risk of reinfection, biological grafts are noteworthy alternatives. The current study evaluated the durability, infection resistance, and midterm outcome of biological grafts in treatment of mycotic abdominal aortic aneurysm. Methods and Results-All patients treated with biological graft in 6 countries between 2006 and 2016 were included. Primary outcome measures were 30- and 90-day survival, treatment-related mortality, and reinfection rate. Secondary outcome measures were overall mortality and graft patency. Fifty-six patients (46 males) with median age of 69 years (range 35-85) were included. Sixteen patients were immunocompromised (29%), 24 (43%) had concomitant infection, and 12 (21%) presented with rupture. Bacterial culture was isolated from 43 (77%). In-situ aortic reconstruction was performed using autologous femoral veins in 30 patients (54%), xenopericardial tube-grafts in 12 (21%), cryopreserved arterial/venous allografts in 9 (16%), and fresh arterial allografts in 5 (9%) patients. During a median follow-up of 26 months (range 3 weeks-172 months) there were no reinfections and only 3 patients (5%) required assistance with graft patency. Thirty-day survival was 95% (n=53) and 90-day survival was 91% (n=51). Treatment-related mortality was 9% (n=5). Kaplan-Meier estimation of survival at 1 year was 83% (95% confidence interval, 73%-94%) and at 5 years was 71% (52%-89%). Conclusions-Mycotic abdominal aortic aneurysm repair with biological grafts is a durable option for patients fit for surgery presenting an excellent infection resistance and good overall survival.

Place, publisher, year, edition, pages
WILEY, 2018
Keywords
allograft, aneurysm, aorta, autologous vein, femoral vein, graft, in situ reconstruction, infection, vein
National Category
Cardiac and Cardiovascular Systems Surgery
Identifiers
urn:nbn:se:uu:diva-372905 (URN)10.1161/JAHA.117.008104 (DOI)000452696000008 ()29886419 (PubMedID)
Available from: 2019-01-11 Created: 2019-01-11 Last updated: 2019-01-11Bibliographically approved
Sörelius, K. (2018). Re: "Management of Atherosclerotic Carotid and Vertebral Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)" [Letter to the editor]. European Journal of Vascular and Endovascular Surgery, 55(1), 142-142
Open this publication in new window or tab >>Re: "Management of Atherosclerotic Carotid and Vertebral Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)"
2018 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 55, no 1, p. 142-142Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Saunders Elsevier, 2018
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-350663 (URN)10.1016/j.ejvs.2017.10.015 (DOI)000424147800012 ()29208349 (PubMedID)
Available from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-05-15Bibliographically approved
Sörelius, K., Mani, K., Björck, M. & Wanhainen, A. (2017). Endovascular treatment of mycotic aortic aneurysms: a paradigm shift. Journal of Cardiovascular Surgery, 58(6), 870-874
Open this publication in new window or tab >>Endovascular treatment of mycotic aortic aneurysms: a paradigm shift
2017 (English)In: Journal of Cardiovascular Surgery, ISSN 0021-9509, E-ISSN 1827-191X, Vol. 58, no 6, p. 870-874Article, review/survey (Refereed) Published
Abstract [en]

Treatment of mycotic aortic aneurysms (MAAs) composes a particularly difficult challenge. Open repair has been considered the gold standard, despite lack of evidence supporting its superiority compared with the emerging alternative endovascular aortic repair (EVAR). This review discusses the pros and cons of EVAR for MAAs by dissecting the three largest publications on MAAs, and concludes that there has been a paradigm shift in treatment of MAAs for the benefit of EVAR.

National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-335156 (URN)10.23736/S0021-9509.17.10069-8 (DOI)000413016100009 ()28627863 (PubMedID)
Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2018-03-29Bibliographically approved
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