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Johansson, Hans-Erik
Publications (10 of 10) Show all publications
Hänni, A., Nilsen, I. & Johansson, H.-E. (2018). Increased circulating magnesium concentrations after Roux-en-Y gastric bypass surgery in patients with type 2 diabetes. Surgery for Obesity and Related Diseases, 14(5), 576-582
Open this publication in new window or tab >>Increased circulating magnesium concentrations after Roux-en-Y gastric bypass surgery in patients with type 2 diabetes
2018 (English)In: Surgery for Obesity and Related Diseases, ISSN 1550-7289, E-ISSN 1878-7533, Vol. 14, no 5, p. 576-582Article in journal (Refereed) Published
Abstract [en]

Background: Low circulating magnesium concentrations predict cardiovascular and all-cause mortality in patients with type 2 diabetes (T2D). Epidemiologic and clinical studies have indicated lower extra- and intracellular magnesium concentrations in patients with diabetes.

Objective: We aimed to describe alterations, if any, in circulating magnesium concentrations after laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in patients with obesity and T2D.

Setting: Outpatient clinic of obesity and central hospital.

Methods: Retrospective analysis of 1-year outcome of plasma magnesium (p-Mg) and glucometabolic status in all consecutive patients who underwent primary LRYGBP and who completed the follow-up visits, including biochemical test panels 6 and 12 months after surgery.

Results: LRYGBP and complete follow-up visits were performed in 51 patients with T2D and 86 patients without T2D. All patients were given similar dietary advice and multivitamin and mineral supplementation after surgery. Before RYGB, the patients with T2D showed lower p-Mg compared with patients without T2D (.79 ± .06 mM and .82 ± .05 mM, respectively, P<.01). P-Mg was inversely correlated to fasting blood glucose and glycosylated hemoglobin levels. After surgery, mean p-Mg increased by 5.2% in the group with T2D compared with 1.4% in the patients without T2D (P<.01), ending at an equal level of .83 mM. The alterations in p-Mg were inversely related to the changes in fasting glucose and glycosylated hemoglobin concentrations.

Conclusion: The lowered p-Mg associated with impaired glucometabolic status in patients with T2D was increased after LRYGBP, reaching similar concentrations as in patients without T2D.

Keywords
Gastric bypass, Diabetes, Magnesium, Obesity
National Category
Endocrinology and Diabetes Gastroenterology and Hepatology
Identifiers
urn:nbn:se:uu:diva-357579 (URN)10.1016/j.soard.2018.01.041 (DOI)000433646200006 ()29567058 (PubMedID)
Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2019-01-18
Johansson, H.-E., Wahlen, A., Aldenback, E. & Hänni, A. (2018). Platelet Counts and Liver Enzymes After Gastric Bypass Surgery. Obesity Surgery, 28(6), 1526-1531
Open this publication in new window or tab >>Platelet Counts and Liver Enzymes After Gastric Bypass Surgery
2018 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 28, no 6, p. 1526-1531Article in journal (Refereed) Published
Abstract [en]

Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP). One hundred twenty-four morbidly obese non-diabetic patients were evaluated before (baseline) and 12 months after (follow-up) RYGBP. Body mass index (BMI) was reduced from 43.5 kg/m(2) (baseline) to 31.1 kg/m(2) (follow-up), and p < 0.001 and weight declined from 126.2 to 89.0 kg. PCs decreased from 303 x 10(9) to 260 x 10(9)/l, p < 0.001. GGT was reduced from 0.63 to 0.38 mu kat/l, p < 0.001. ALT decreased from 0.69 to 0.59 mu kat/l, p = 0.006. CRP was lowered from 7.3 to 5.4 mg/l p < 0.001 and ferritin from 106 to 84 mu g/l p < 0.001. The alterations in PCs correlated with the changes in CRP (r = 0.38, p = 0.001), BMI (r = 0.25, p = 0.012), weight (r = 0.24, p = 0.015) and inversely correlated with ferritin (r = 21, p = 0.036). PCs, GGT and ALT (markers for NAFLD), and CRP and ferritin (markers for inflammation) decreased in morbidly obese after RYGBP. The decrease in PCs correlated with alterations in CRP, BMI, weight and ferritin. The lowering of liver enzymes may reflect a lowered liver fat content and decreased general inflammation.

Place, publisher, year, edition, pages
SPRINGER, 2018
Keywords
Morbid obesity, Gastric bypass, Platelet counts, Gamma-glutamyltransferase, Alanine aminotransferase, C-reactive protein, Ferritin
National Category
Surgery Gastroenterology and Hepatology
Identifiers
urn:nbn:se:uu:diva-358170 (URN)10.1007/s11695-017-3035-5 (DOI)000433544000010 ()29222767 (PubMedID)
Available from: 2018-08-24 Created: 2018-08-24 Last updated: 2018-08-24Bibliographically approved
Hallberg, P., Nagy, J., Karawajczyk, M., Nordang, L., Islander, G., Norling, P., . . . Wadelius, M. (2017). Comparison of Clinical Factors Between Patients With Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema and Cough. The Annals of Pharmacotherapy, 51(4), 293-300
Open this publication in new window or tab >>Comparison of Clinical Factors Between Patients With Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema and Cough
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2017 (English)In: The Annals of Pharmacotherapy, ISSN 1060-0280, E-ISSN 1542-6270, Vol. 51, no 4, p. 293-300Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Angioedema is a rare and serious adverse drug reaction (ADR) to angiotensin-converting enzyme (ACE) inhibitor treatment. Dry cough is a common side effect of ACE inhibitors and has been identified as a possible risk factor for angioedema.

OBJECTIVE: We compared characteristics between patients with ACE inhibitor-induced angioedema and cough with the aim of identifying risk factors that differ between these adverse events.

METHODS: Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians. Wilcoxon rank sum test, Fisher's exact test, and odds ratios (ORs) with 95% CIs were used to test for between-group differences. The significance threshold was set to P <0.00128 to correct for multiple comparisons.

RESULTS: Clinical characteristics were compared between 168 patients with angioedema and 121 with cough only. Smoking and concomitant selective calcium channel blocker treatment were more frequent among patients with angioedema than cough: OR = 4.3, 95% CI = 2.1-8.9, P = 2.2 × 10(-5), and OR = 3.7, 95% CI = 2.0-7.0, P = 1.7 × 10(-5). Angioedema cases were seen more often in male patients (OR = 2.2, 95% CI = 1.4-3.6, P = 1.3 × 10(-4)) and had longer time to onset and higher doses than those with cough ( P = 3.2 × 10(-10) and P = 2.6 × 10(-4)). A multiple model containing the variables smoking, concurrent calcium channel blocker treatment, male sex, and time to onset accounted for 26% of the variance between the groups.

CONCLUSION: Smoking, comedication with selective calcium channel blockers, male sex, and longer treatment time were associated with ACE inhibitor-induced angioedema rather than cough.

Keywords
ACE inhibitors, adult medicine, adverse drug reactions, calcium-channel blockers, clinical pharmacology, drug safety, interactions, medication safety, pulmonary
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-316913 (URN)10.1177/1060028016682251 (DOI)000396799400003 ()27889699 (PubMedID)
Funder
Swedish Research CouncilSwedish Heart Lung Foundation
Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2018-02-01Bibliographically approved
Wahlen, A., Haenni, A. & Johansson, H.-E. (2017). Do we need to measure vitamin B12 and magnesium in morbidly obese patients with type 2 diabetes mellitus?. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 10, 151-154
Open this publication in new window or tab >>Do we need to measure vitamin B12 and magnesium in morbidly obese patients with type 2 diabetes mellitus?
2017 (English)In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, ISSN 1178-7007, E-ISSN 1178-7007, Vol. 10, p. 151-154Article in journal (Refereed) Published
Abstract [en]

Objective: We aimed to investigate the prevalence of B12 deficiency in metformin-treated, morbidly obese, type 2 diabetes mellitus (T2DM) patients, compared to morbidly obese controls, as well as to evaluate the magnesium status. Design: Retrospective cross-sectional analysis of plasma vitamin B12, plasma magnesium, glucometabolic status and clinical measurements in all consecutive morbidly obese patients was conducted during 1 year. Setting: Outpatient Clinic of Obesity Care. Subjects: One hundred forty-seven patients were evaluated: 107 morbidly obese controls and 40 metformin-treated, morbidly obese patients with T2DM. Main outcome measures: Circulating plasma concentrations of vitamin B12 (cobalamin), magnesium, clinical measurements and metformin medication. Results: There were differences between the two groups regarding age, sagittal diameter, glucose parameters and magnesium concentrations. Longer diabetes duration was associated with lower magnesium. Metformin-treated T2DM patients had lower magnesium (0.76 +/- 0.07 mmol/L) than controls (0.82 +/- 0.07 mmol/L). A subgroup analysis of 26 non-metformin-treated T2DM patients showed a normal magnesium concentration compared to controls, that is, 0.81 +/- 0.06 mmol/L. We found no statistical difference in B12 concentrations between the two groups. Conclusion: To fully benefit from metformin medication, routine testing of B12 as well as magnesium in metformin-treated, morbidly obese patients should be performed, with consideration of substitution to avoid low levels.

Place, publisher, year, edition, pages
DOVE MEDICAL PRESS LTD, 2017
Keywords
metformin medication, vitamin B12, magnesium, type 2 diabetes mellitus, morbidly obese
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-323675 (URN)10.2147/DMSO.S131340 (DOI)000400515300001 ()28496346 (PubMedID)
Available from: 2017-06-09 Created: 2017-06-09 Last updated: 2017-06-09Bibliographically approved
Hallberg, P., Persson, M., Axelsson, T., Cavalli, M., Norling, P., Johansson, H.-E., . . . Wadelius, M. (2017). Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population. Pharmacogenomics (London), 18(3), 201-213
Open this publication in new window or tab >>Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population
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2017 (English)In: Pharmacogenomics (London), ISSN 1462-2416, E-ISSN 1744-8042, Vol. 18, no 3, p. 201-213Article in journal (Refereed) Published
Abstract [en]

Aim: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes iden-tified in previous studies. Patients & methods: A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 x 10(-8). Results: We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 x 10(-8)). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study. Conclusion: Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.

Place, publisher, year, edition, pages
FUTURE MEDICINE LTD, 2017
Keywords
angiotensin converting enzyme inhibitors, bradykinin, cough, drug-related side effects and adverse reactions, enalapril, genome-wide association study, lisinopril, pharmacogenetics, quinapril, ramipril
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-318602 (URN)10.2217/pgs-2016-0184 (DOI)000393682600002 ()28084903 (PubMedID)
Funder
Swedish Research Council, Medicine 521-2011-2440 521-2014-3370Swedish Heart Lung Foundation, 20120557 20140291Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Available from: 2017-03-31 Created: 2017-03-31 Last updated: 2018-01-13Bibliographically approved
Johansson, H.-E., Haenni, A. & Zethelius, B. (2013). Platelet counts and liver enzymes after bariatric surgery. Journal of Obesity, 2013, 567984
Open this publication in new window or tab >>Platelet counts and liver enzymes after bariatric surgery
2013 (English)In: Journal of Obesity, ISSN 2090-0708, E-ISSN 2090-0716, Vol. 2013, p. 567984-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP).

METHODS: Ten morbidly obese patients (body mass index, BMI: 53.5 ± 3.8 kg/m(2)) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI: 42.3 ± 5.2 kg/m(2)) who underwent RYGBP.

RESULTS: Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (-44%/-24%), GGT (-63%/-52%), and ALT (-48%/-62%). PC decreased (-21%) statistically significantly only in BPD-DS patients.

CONCLUSIONS: Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis.

National Category
General Practice
Identifiers
urn:nbn:se:uu:diva-223217 (URN)10.1155/2013/567984 (DOI)23509615 (PubMedID)
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2018-01-11Bibliographically approved
Johansson, H.-E., Haenni, A. & Zethelius, B. (2011). Changes in Erythrocyte Sedimentation Rate, White Blood Cell Count, Liver Enzymes, and Magnesium after Gastric Bypass Surgery. Journal of Obesity, 2011, 273105
Open this publication in new window or tab >>Changes in Erythrocyte Sedimentation Rate, White Blood Cell Count, Liver Enzymes, and Magnesium after Gastric Bypass Surgery
2011 (English)In: Journal of Obesity, ISSN 2090-0708, E-ISSN 2090-0716, Vol. 2011, p. 273105-Article in journal (Refereed) Published
Abstract [en]

Roux-en-Y gastric bypass (RYGBP) is an established method for treatment of obesity, a condition of chronic inflammation with liver steatosis, characterised by increased erythrocyte sedimentation rate (ESR), white blood cell count (WBC), liver enzymes, and decreased magnesium (Mg).We investigated alterations, if any, in ESR, WBC, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and Mg after RYGBP. Methods. 21 morbidly obese nondiabetic patients who underwent RYGBP surgery were evaluated preoperatively (baseline), then 1 year (1st followup) and 3.5 years (2nd followup) after RYGBP and compared to an untreated control group. Results. Body mass index, ESR, WBC, ALT, and GGT were all significantly reduced at 1 year in the RYGBP group (30%, 35%, 20%, 45%, and 57%, resp.) while Mg increased by 6%, compared to control group (P = 0.001 − 0.009). Conclusions. Obese patients treated by RYGBP show sustained reductions in ESR, WBC, ALT, and GGTpossibly due to reduced liver steatosis and increased Mg.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2011
Keywords
Erythrocyte sedimentation rate, White blood cell count, Gatric bypass
National Category
Surgery
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-165449 (URN)10.1155/2011/273105 (DOI)
Available from: 2012-01-09 Created: 2012-01-07 Last updated: 2017-12-08Bibliographically approved
Johansson, H.-E., Hänni, A., Karlsson, F. A., Edén-Engström, B., Öhrvall, M., Sundbom, M. & Zethelius, B. (2010). Bileopancreatic Diversion with Duodenal Switch lowers both Early and Late Phases of Glucose, Insulin and Proinsulin responses after Meal. Obesity Surgery, 20(5), 549-558
Open this publication in new window or tab >>Bileopancreatic Diversion with Duodenal Switch lowers both Early and Late Phases of Glucose, Insulin and Proinsulin responses after Meal
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2010 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 20, no 5, p. 549-558Article in journal (Refereed) Published
Abstract [en]

Hyperproinsulinemia is associated with obesity and type 2 diabetes. We explored the after-meal dynamics of proinsulin and insulin and postprandial effects on glucose and lipids in patients treated with bileopancreatic diversion with duodenal switch (BPD-DS) surgery compared with normal-weight controls [body mass index (BMI)+/- SD, 23.2 +/- 2.4 kg/m(2)].

Ten previously morbidly obese (BMI +/- SD, 53.5 +/- 3.8 kg/m(2)) patients free from diabetes who had undergone BPD-DS (BMI +/- SD, 29.0 +/- 5.2 kg/m(2)) 2 years earlier were recruited. A standardised meal (2400 kJ) was ingested, and glucose, proinsulin, insulin, free fatty acids and triglycerides (TGs) were determined during 180 min. Follow-up characteristics yearly on glucose, lipids, creatinine and uric acid over 3 years after BPD-DS are presented.

Fasting glucose and insulin were lower, 0.4 mmol/L and 4.6 pmol/L, respectively, in the BPD-DS group despite higher BMI. Fasting proinsulin was similar in both groups. Postprandial area under the curve (AUC) for glucose, proinsulin and insulin did not differ between the two groups (p = 0.106-734). Postprandial changes in glucose, proinsulin and insulin were essentially similar but absolute concentrations of proinsulin and insulin were lower in the later phases in the BPD-DS group (p = 0.052-0.001). Postprandial AUC for TGs was lower in the BPD-DS group (p = 0.005). Postprandial changes in TGs were lowered in the intermediate phase (p = 0.07-0.08) and in the late phase (0.002). Follow-up data showed markedly lowered creatinine and uric acid after BPD-DS.

BPD-DS surgery induces a large weight loss and lowers, close to normal, postprandial responses of glucose, proinsulin and insulin but with marked lowering of TGs.

Keywords
Proinsulin; Insulin; Obesity; Bileopancreatic diversion with duodenal switch
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-111314 (URN)10.1007/s11695-010-0102-6 (DOI)000276470700003 ()20198453 (PubMedID)
Available from: 2009-12-09 Created: 2009-12-09 Last updated: 2017-12-12Bibliographically approved
Johansson, H.-E. (2010). The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin. (Doctoral dissertation). Uppsala: Acta Universitatis Upsaliensis
Open this publication in new window or tab >>The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Hyperproinsulinemia is associated with type 2 diabetes (T2DM) and obesity and is a predictor for future coronary heart disease. This thesis examines the effect of bariatric surgery on glucometabolic status including insulin and proinsulin responses after meal. Further we explored longitudinally the effects of bariatric surgery on glucose, insulin and proinsulin secretion as well as lipids, liver enzymes and magnesium concentrations.

We explored by a standardised meal test the postprandial dynamics of proinsulin and insulin and effects on glucose and lipids in patients treated with gastric bypass (RYGBP) surgery and in patients treated with bileopancreatic diversion with duodenal switch surgery (BPD-DS). Comparisons were made to morbidly obese patients and normal weight controls (NW). RYGBP surgery markedly lowers fasting and postprandial proinsulin concentrations although BMI was higher compared to NW-controls. BPD-DS surgery induces a large weight loss and normalises postprandial responses of glucose, proinsulin and insulin and markedly lowers triglycerides.

We evaluated non-diabetic morbidly obese patients who underwent bariatric surgery followed-up for up to four years after surgery. Long-term follow-up showed that RYGBP surgery is not only characterized by markedly and sustained lowered BMI but also lowered concentrations of proinsulin, insulin, ALT and increased HDL-C possibly via reduced hepatic insulin resistance.

We also examined how magnesium status is affected by bariatric surgery as magnesium has been shown to be inversely related to glucose and to insulin resistance. The serum magnesium concentrations increased by 6% after RYGBP and 10% after BPD-DS.

In summary, RYGBP and BPD-DS surgery results in marked weight loss, alterations in insulin and proinsulin dynamics, lowered fasting and postprandial proinsulin concentrations and improved glucometabolic and magnesium status.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. p. 78
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 511
Keywords
Proinsulin, insulin, glucose, obesity, bariatric surgery
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-111316 (URN)978-91-554-7695-3 (ISBN)
Public defence
2010-02-10, Universitetshuset, sal IV, Universitetshuset Uppsala Universitet 740 10 Uppsala, Uppsala, 09:30 (Swedish)
Opponent
Supervisors
Available from: 2010-01-19 Created: 2009-12-09 Last updated: 2010-01-19Bibliographically approved
Johansson, H.-E., Zethelius, B., Öhrvall, M., Sundbom, M. & Haenni, A. (2009). Serum Magnesium Status After Gastric Bypass Surgery in Obesity. Obesity Surgery, 19(9), 1250-1255
Open this publication in new window or tab >>Serum Magnesium Status After Gastric Bypass Surgery in Obesity
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2009 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 19, no 9, p. 1250-1255Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Roux-en-Y gastric bypass (RYGBP) has become a common surgical procedure to treat morbid obesity. Furthermore, it strongly reduces the incidence of type 2 diabetes and mortality. However, there is scant information on how magnesium status is affected by RYGBP surgery. Previous bariatric surgery methods, like jejunoileal bypass, are associated with hypomagnesemia. METHODS: Twenty-one non-diabetic morbidly obese patients who underwent RYGBP were evaluated before and 1 year after surgery and compared to a matched morbidly obese control group regarding serum magnesium. Groups were matched regarding weight, BMI, abdominal sagittal diameter and fasting glucose, blood pressure, and serum magnesium concentrations before surgery in the RYGBP group. RESULTS: The serum magnesium concentrations increased by 6% from 0.80 to 0.85 mmol/l (p = 0.019) in the RYGBP group while a decrease by 4% (p = 0.132) was observed in the control group. The increase in magnesium concentration at the 1-year follow-up in the RYGBP group was accompanied by a decreased abdominal sagittal diameter (r (2) = 0.32, p = 0.009), a lowered BMI (r (2) = 0.28, p = 0.0214), a lowered glucose concentration (r (2) = 0.28, p = 0.027) but not by a lowered insulin concentration (p = 0.242), a lowered systolic (p = 0.789) or a lowered diastolic (p = 0.785) blood pressure. CONCLUSION: RYGBP surgery in morbidly obese subjects is characterized by reduced visceral adiposity, lowered plasma glucose, and increased circulating magnesium concentrations. The inverse association between lowered central obesity, lowered plasma glucose and increased magnesium concentrations, needs further detailed studies to identify underlying mechanisms.

Keywords
Morbid obesity, Gastric bypass surgery, Magnesium
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-17697 (URN)10.1007/s11695-008-9536-5 (DOI)000269153200009 ()18542850 (PubMedID)
Available from: 2008-08-15 Created: 2008-08-15 Last updated: 2017-12-08Bibliographically approved
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