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Sten, Sabine
Publications (10 of 26) Show all publications
Muehlemann, B., Margaryan, A., Damgaard, P. d., Allentoft, M. E., Vinner, L., Hansen, A. J., . . . Jones, T. C. (2018). Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. Proceedings of the National Academy of Sciences of the United States of America, 115(29), 7557-7562
Open this publication in new window or tab >>Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans
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2018 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, no 29, p. 7557-7562Article in journal (Refereed) Published
Abstract [en]

Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.

Place, publisher, year, edition, pages
NATL ACAD SCIENCES, 2018
Keywords
parvovirus B19, ancient DNA, virus evolution, paleo virology, virology
National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-361692 (URN)10.1073/pnas.1804921115 (DOI)000438892600059 ()29967156 (PubMedID)
Funder
EU, FP7, Seventh Framework Programme, 278976EU, Horizon 2020, 643476
Available from: 2018-09-27 Created: 2018-09-27 Last updated: 2018-09-27Bibliographically approved
Sten, S., Lovén, C., Kjellström, A., Liden, K., Vretemark, M., Hongslo Vala, C., . . . Jakobsson, M. (2016). Erik den heliges skelett. Fornvännen, 111(1), 27-40
Open this publication in new window or tab >>Erik den heliges skelett
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2016 (English)In: Fornvännen, ISSN 0015-7813, E-ISSN 1404-9430, Vol. 111, no 1, p. 27-40Article in journal (Refereed) Published
Abstract [en]

Saint Erik was King of Sweden for a few years up to 1160, when he was killed. A skeleton attributed to him is kept in Uppsala Cathedral. It underwent scientific reappraisal in 2014. The analyses included computer tomography, Xray absorptiometry, isotope analysis and DNA sampling. Radiocarbon confirms the alleged age of the bones. They belong to a 35-40-year-old man in excellent physical shape. The many wounds that he received in connection with his death fit surprisingly well with the saint's legend, whose preserved version was written 130 years after the event.

National Category
Archaeology History
Identifiers
urn:nbn:se:uu:diva-313305 (URN)000389738300004 ()
Note

English title in Web of Science: Saint Erik's skeleton.

Available from: 2017-01-18 Created: 2017-01-18 Last updated: 2017-11-29Bibliographically approved
Vala, C. H., Karrholm, J., Sten, S., Karlsson, M., Sundh, V., Lorentzon, M. & Mellstrom, D. (2016). Risk For Hip Fracture 10 Years Before And After Total Knee Replacement Surgery In The Entire Swedish Population. Paper presented at WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, APR 14-17, 2016, Malaga, SPAIN. Osteoporosis International, 27, S46-S46
Open this publication in new window or tab >>Risk For Hip Fracture 10 Years Before And After Total Knee Replacement Surgery In The Entire Swedish Population
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2016 (English)In: Osteoporosis International, ISSN 0937-941X, E-ISSN 1433-2965, Vol. 27, p. S46-S46Article in journal, Meeting abstract (Other academic) Published
National Category
Orthopaedics
Identifiers
urn:nbn:se:uu:diva-299782 (URN)000376469100023 ()
Conference
WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, APR 14-17, 2016, Malaga, SPAIN
Available from: 2016-07-27 Created: 2016-07-27 Last updated: 2018-01-10Bibliographically approved
Sten, S. (2015). Dämba 279, Fårö socken, Gotland: En osteologisk analys av två gravar.
Open this publication in new window or tab >>Dämba 279, Fårö socken, Gotland: En osteologisk analys av två gravar
2015 (Swedish)Report (Other academic)
Publisher
p. 8
Series
Osteologisk Rapportserie ; 2015:2
Keywords
Bronze Age, Fårö, Gotland, Dämba, graves, osteology, archaelogy, Bronsålder, Fårö, Gotland, Dämba, gravar, osteologi, arkeologi
National Category
Archaeology
Research subject
Archaeology
Identifiers
urn:nbn:se:uu:diva-280283 (URN)
Available from: 2016-03-09 Created: 2016-03-09 Last updated: 2016-03-10Bibliographically approved
Sten, S. (2015). Slutrapport i Genomförandeprojektet Osteoporosis och osteoarthritis, då och nu.
Open this publication in new window or tab >>Slutrapport i Genomförandeprojektet Osteoporosis och osteoarthritis, då och nu
2015 (Swedish)Report (Other academic)
Publisher
p. 25
Series
Osteologisk Rapportserie ; 2015:1
Keywords
Osteoporosis, osteoarthritis, archaeology, osteology, Osteoporos, osteoarthritis, arkeologi, osteologi
National Category
Archaeology
Identifiers
urn:nbn:se:uu:diva-280281 (URN)
Projects
Osteoporosis och osteoarthritis, då och nu
Funder
Knowledge Foundation
Available from: 2016-03-09 Created: 2016-03-09 Last updated: 2016-03-10Bibliographically approved
Sten, S. (2013). Gamle fiskbein, styr, strämming, tåsk med fleira. Hushållningssällskapet Gotlands tidskrift (3), 21-23
Open this publication in new window or tab >>Gamle fiskbein, styr, strämming, tåsk med fleira
2013 (Swedish)In: Hushållningssällskapet Gotlands tidskrift, ISSN 2000-5784, no 3, p. 21-23Article in journal (Other academic) Published
Place, publisher, year, edition, pages
Romakloster: Gotlands läns hushållningssällskap, 2013
Keywords
Gotland, historia, fiske
National Category
History
Identifiers
urn:nbn:se:uu:diva-209291 (URN)
Note

Förkortad version i tidskriften

Available from: 2013-10-16 Created: 2013-10-16 Last updated: 2013-10-16
Sten, S. (2013). Gamle fiskbein, styr, strämming, tåsk med fleira. Uppsala universitet
Open this publication in new window or tab >>Gamle fiskbein, styr, strämming, tåsk med fleira
2013 (Swedish)Report (Other academic)
Place, publisher, year, edition, pages
Uppsala universitet, 2013. p. 7
Keywords
Historia, Gotland, fiske
National Category
History
Identifiers
urn:nbn:se:uu:diva-209294 (URN)
Available from: 2013-10-16 Created: 2013-10-16 Last updated: 2013-10-16Bibliographically approved
Fraser, M., Sten, S. & Götherström, A. (2012). Neolithic Hedgehogs (Erinaceus europaeus) from the Island of Gotland show early contacts with the Swedish mainland. Journal of Archaeological Science, 39(2), 229-233
Open this publication in new window or tab >>Neolithic Hedgehogs (Erinaceus europaeus) from the Island of Gotland show early contacts with the Swedish mainland
2012 (English)In: Journal of Archaeological Science, ISSN 0305-4403, E-ISSN 1095-9238, Vol. 39, no 2, p. 229-233Article in journal (Refereed) Published
Abstract [en]

Previous research probing early migrations and contacts in the Baltic Sea area is characterized by the analysis of different chronologies and subsistent strategies on all sides of the Sea. Several studies performed on artifact typology, ceramics, grave rituals and physical anthropology ended with varying results. Although the question of human origins remains inconclusive, in this study, we rely on the phylogeography of an animal associated with humans to elucidate findings regarding prehistoric human migration and contacts.

Hedgehogs, along with other fauna on Gotland, were brought over to the island by humans. We examined hedgehog mitochondrial DNA from the Pitted Ware Culture (Middle Neolithic). The genetic signatures of the animals on the island were investigated to determine the animals origin.

From the 23 bones originally examined, twelve bones from all five locations studied yielded reliable results and resembled published extant Erinaceus europaeus sequences from Sweden, Norway and Denmark. We postulate that a western heritage for the Neolithic hedgehogs on Gotland indicates early human contact with the Swedish mainland.

Place, publisher, year, edition, pages
London: Academic Press, 2012
Keywords
Phylogeography, ancient DNA, mtDNA, osteology, Erinaceus europaeus, Erinaceus concolor, Neolithic, Sweden
National Category
Genetics Archaeology
Identifiers
urn:nbn:se:hgo:diva-1170 (URN)10.1016/j.jas.2011.08.006 (DOI)
Note
Published online Oct 28, 2011Available from: 2011-11-30 Created: 2011-11-30 Last updated: 2017-12-08Bibliographically approved
Sten, S. & Mellström, D. (2011). Vad kan gamla arkeologiska skelettfynd bidra med i dagens medicinska forskning om osteoporos?. Osteoporos-nytt (4), 4-5
Open this publication in new window or tab >>Vad kan gamla arkeologiska skelettfynd bidra med i dagens medicinska forskning om osteoporos?
2011 (Swedish)In: Osteoporos-nytt, ISSN 1404-6199, no 4, p. 4-5Article in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Riksföreningen Osteoporotiker (ROP), 2011
Keywords
Benskörhet, Gotland
National Category
Archaeology General Practice
Identifiers
urn:nbn:se:hgo:diva-1358 (URN)
Available from: 2012-02-23 Created: 2012-02-23 Last updated: 2018-01-12Bibliographically approved
Fraser, M., Sten, S. & Malmborg, G. (2010). Ancient DNA Preserved in 5000 Year Old Hedgehog Bones. In: Paul Wallin, Helene Martinsson Wallin (Ed.), The Gotland Papers: Selected Papers from the VII International Conference on Easter Island and the Pacific : Migration, Identity, and Cultural Heritage (pp. 507-510). Gotland University Press
Open this publication in new window or tab >>Ancient DNA Preserved in 5000 Year Old Hedgehog Bones
2010 (English)In: The Gotland Papers: Selected Papers from the VII International Conference on Easter Island and the Pacific : Migration, Identity, and Cultural Heritage / [ed] Paul Wallin, Helene Martinsson Wallin, Gotland University Press, 2010, p. 507-510Chapter in book (Other academic)
Abstract [en]

The patterns of DNA degradation are partly known. Cold and dry environments with a neutral or slightly above neutral pH will preserve DNA better than hot, humid, or acidic conditions. But little is yet known on what types of material preserves DNA. So far, most of the genetic studies on ancient specimens have been conducted on mammals with large bones, few studies have been done on micro mammals. Here we investigate the possibility to retrieve DNA from small mammalian bones, from hedgehogs, from the Baltic island Gotland. We use bones from ancient hedgehogs from known archaeological sites. Of the 13 samples used in the study, all between 5000 and 1000 years old, 6 yielded reproducible DNA that could be assigned to hedgehog. We conclude that it is possible to retrieve DNA, and that this opens the possibility to study early migrations routs to the Baltic island Gotland.

Place, publisher, year, edition, pages
Gotland University Press, 2010
Series
Gotland University Press, ISSN 1653-7424 ; 11
National Category
History and Archaeology
Identifiers
urn:nbn:se:hgo:diva-1829 (URN)978-91-86343-07-1 (ISBN)
Available from: 2013-03-15 Created: 2013-03-15 Last updated: 2013-07-01Bibliographically approved
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